BIOLOGICAL IMPLANTS MARKET SIZE Scope of the Study Biological Implants Report provides a progressive insight into the market for several types of Bioimplants by Origin and Mode of Administration. The product is segmented by Tissue/Muscle into Orthopedic, Soft Tissue, Cardiovascular, and Other (Dental, Ophthalmic and Urologic). The market is further analyzed by origin (Allograft and Xenograft), and by mode of administration (Injectable and Surgical). Projections and estimates are graphically illustrated by geographic regions encompassing North America, Europe, Asia-Pacific, and Rest of World. Business profiles of 25 major companies are discussed in the report. The report serves as a guide to global Biological Implants industry covering more than 164 companies that are engaged in Bioimplant R&D, manufacturing, testing and supply of products and services. Major Contract Research Organizations and Universities serving the industry are also covered in the Corporate Directory section of this report. Information related to recent product releases, product developments, partnerships, collaborations, mergers and acquisitions, ethical issues, regulatory affairs, and other areas of concern is also covered in the report. This research report on Biological Implants is an ideal research tool providing strategic business intelligence to the corporate sector. This report may help strategists, investors, laboratories, pharmaceutical companies, contract research organizations, biotechnology companies and drug approval authorities in- Gauging Competitive Intelligence Identifying Key Growth Areas and Opportunities Understanding Geographic Relevance to Product Knowing Regional Market Sizes and Growth Opportunities and Restraints Keeping Tab on Emerging Technologies Equity Analysis Tapping New Markets
Analytics and data presented in this report pertain to several parameters such as – Global And Regional Market Sizes, Market Shares, Market Trends Product (Global And Regional) Market Sizes, Market Shares, Market Trends Technology Trends Corporate Intelligence Key Companies By Sales, Brands, Products Consumer Behavioral Patterns
RITMIR010: Biological Implants – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
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Other Strategic Business Affecting Data
Research Methodology RI Technologies publishes business intelligence reports by going through a cycle of diligent research and analysis activity. Research is done using both online and offline resources. The study outline of this report is sketched on the following lines – global market analysis, regional market analysis, product segmentation, global and regional market analysis by product segment, market trends, M&A, R&D, competitive landscape, technology trends, and other key drivers. Current data helps in analyzing the future of the industry and is also helpful for doing market evaluations, and estimating the market size for the future.
This report is uniquely researched and the methodology includes: Need and Scope of Study Product Definitions Segmental Analysis Regional Analysis Exclusive Data Analytics Corporate Intelligence Feedback
Right from concept to final compilation of this report, both primary and secondary research methods are applied. We have provided exclusive feedback forms/pre-release questionnaires for this report to use the information for authentication of our own findings. Secondary research includes government publications, investment research reports, web based surveys, website information of both companies and markets, and other offline resources such as print publications and CDs. Our compilation of easy to navigate PDF reports are essential value addition resources for leading and growing companies.
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II. REPORT SYNOPSIS FOREWORD Biological Implants – A Revolutionary Human Repair Technique Biological Implants are testimony to the huge advancements in medical science. The development of different types of implantable biomaterials according to the specified strength characteristics, conservation of significant biochemical properties, the lower immunogenity and higher inductivity of regenerative processes enables to carry out appropriate studies on the biochemical reactions following the implantation of biomaterials. This illustrates the peculiarities of the regeneration processes of various types of bioimplant materials during the application. These implants are predicted to enhance the quality of life. The blend of scientific research, clinical application and commercial advancement has created a new outlook to the treatment based on biological implants. The prospects of the use of materials in different areas of surgery, the protection against infection and the use of biological implants outside the authorized indications are of main concern. This report analyzes the current biological implant procedures. Synopsis chapter of the report gives the summary of total biological implants market by tissue/muscle; origin, and mode of administration at global level and for each of the geographic regions - North America, Europe, Asia-Pacific and Rest of World.
Segmentation of Biological Implants This report on Biological Implants analyzes the global market for biological implant procedures. The total biological implants market is analyzed by tissue/muscle; origin, and mode of administration at global level and for each of the geographic regions - North America, Europe, Asia-Pacific and Rest of World. The biological implants market is segmented by Tissue/Muscle into Soft Tissue, Orthopedic, Cardiovascular and Other (includes Dental, Ophthalmic, and Urologic); by Origin into Allograft, and Xenograft; and by Mode of Administration into Injectable and Surgical. Business profiles of 25 major companies are discussed in the report. The report serves as a guide to global biological implants industry covering more 140 companies that are engaged in biological implants’ processing, R&D, storage, banking, discovery, testing and supply of products and services. Major Contract Research Organizations and Universities serving the industry are also covered in the Corporate Directory section of this report. Information related to recent product releases, product developments, partnerships, collaborations, mergers and acquisitions, ethical issues, regulatory affairs, and other areas of concern is also covered in the report. Compilation of Worldwide Patents and Research related to biological implants is also provided. Estimations and Predictions are graphically illustrated by geographic regions by 229 exclusive exhibits.
RITMIR010: Biological Implants – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
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Exhibit 1. Segmentation of Global Biological Implants Market by Tissue/Muscle, by Origin, and by Mode of Administration Tissue/Muscle
Origin
Mode of Administration
Orthopedic
Allograft
Surgical
Soft Tissue
Xenograft
Injectable
Cardiovascular
-
-
Other*
-
-
* Includes Dental, Ophthalmic and Urologic Š RIT, 2013
History of Implants An overwhelming concern about disease and outcome affects life in several ways. This concern is an outcome of any disease or an injury that can bring about alterations in human bodies. Since 1989, much hope has come in this highly complicated stream of implants. In the present moment, a person need not lose his natural self if he suffers the loss of one of his organs or any tissue for that matter. Due to the radical progress made in the realm of science, this has become a thing of the past.
The Need for a Better Implant In earlier times, the wearing of an artificial eye for instance was considered much better than having no eye at all, due to the cosmetic change it brought to the wearer. The wearing of the artificial eye was cumbersome for the person sporting the same and it did not give a natural appearance because it did not have movement. Thus, the first-generation implants lacked a natural appearance. The first-generation implants suffered a lacuna in that the body would reject the implant or force it to move away from its intended orbit. Then the need for establishing a better orbital implant arose, making it obligatory to perform further surgeries to overcome this problem.
Naturally Derived Implants In the quest for a natural appearance scientists stumbled upon the finding of the ocean coral and were astounded to notice the similarity it possessed with the human bone. The porous structure of some coral species was almost identical to the bone of man. Thus the period of naturally derived implants came into being. Scientists found that the transformation of the essential mineral in the coral was hydroxyapatite. This mineral, they discovered, could be matched and the approximation to the human bone could be made more realistic. It was found that since the hydroxyapatite implants exhibited the same porous and chemical structure of the human bone, they were accepted by the surrounding tissue. The tissues then began growing into and around the implant giving it the same status that it afforded to the natural bone. This however was not the case with similar porous material such as medpor or bioceramic. Medpor is actually porous polyethylene and bioceramic is also known as aluminum oxide. So it was seen that naturally derived implants had the property of becoming an essential part of the human body.
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After spending a number of years in introductory research, Dr. Arthur Perry was able to, finally in 1985, perform an eye implant made of hydroxyapatite. This could be declared as the first orbital implant ever to be made from this mineral. The movement of the implanted eye was almost similar to the natural eye because the eye muscles were attached to it. Researchers gradually improved on this eye implant and it was even possible to imbue the artificial eye with the subtle darting movements that are noticed in the natural eye. This was achieved by fitting the artificial eye over the tissues that encase the implant. To endow the artificial eye with a more natural appearance a titanium peg could be used to facilitate enhanced movement. Through all these efforts it was possible to obtain a more natural-appearing artificial eye which could not be easily differentiated by an unsuspecting observer.
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Global Market Analysis Market Analysis of Tissue/Muscle Biological Implants by Geographic Region Registering a CAGR of XX.XX% during the analysis period, the global orthopedic biological implants market is projected to be worth US$ XX.XX billion by 2020. The market was estimated at US$ XX.XX billion in 2012. With an estimated market share of about XX.XX % in 2012, North America represents the largest market for orthopedic Biological Implants with a market worth US$ XX.XX billion. North America is projected to reach US$ XX.XX billion by 2020 by growing at a CAGR of XX.XX % during 2005-2020 to retain the leadership. Europe is expected to be the fastest growing as well as the second largest market with a market share of XX.XX % in 2012, while Asia-Pacific represents second fastest growing market with CAGR of XX.XX %. Exhibit 2. Orthopedic Biological Implants – Global Value Market Estimations and Predictions (2005-2020) in US$ Million for North America, Europe, Asia-Pacific, and Rest of World Year /Region
North America
Europe
Asia-Pacific
Rest of World
Total
2005
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2006
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2007
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2008
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2009
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2010
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2011
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2012
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2013
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2014
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2015
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2016
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2017
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2018
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2019
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2020
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
CAGR%
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
© RIT Figures, 2013
US$ Million
2005
2006
2007
2008
2009
North America
2010
2011
2012
Europe
2013
2014
2015
Asia-Pacific
2016
2017
2018
2019
2020
Rest of World
RITMIR010: Biological Implants – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
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Exhibit 3. List of Major Global Companies S. No
Company
Region
Website
1
Aastrom Biosciences, Inc.
USA
www.aastrom.com
2
Alphatec Spine, Inc.
USA
www.alphatecspine.com
3
CONMED Linvatec
USA
www.conmed.com
4
CryoLife, Inc.
USA
www.cryolife.com
5
Curis, Inc.
USA
www.curis.com
6
Exactech, Inc.
USA
www.exac.com
7
Fascia Biosystems LLC
USA
www.fascian.com
8
Inamed Aesthetics
USA
www.inamed.com
9
IOP, Inc.
USA
www.iopinc.com
10
Integra Lifescience Corporation
USA
www.integra-ls.com
11
LifeCell Corporation
USA
www.lifecell.com
12
NuVasive Inc.
USA
www.nuvasive.com
13
Organogenesis, Inc.
USA
www.organogenesis.com
14
Osteotech, Inc.
USA
www.osteotech.com
15
Pegasus Biologics, Inc.
USA
www.pegasusbio.com
16
Stryker Corporation
USA
www.stryker.com
17
Tutogen Medical, Inc.
USA
www.tutogen.com
More…. © RIT, 2013
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III. MARKET DYNAMICS
Market Overview Biological Implants are gaining importance in the market. Extensive research is being carried out to improve the already existing Biological Implants and also to develop various other biological sources which can be used as Biological Implants. The technology in medical science is rapidly growing. Earlier, Biological Implants were considered to be the last option. Nowadays, bone grafts and soft tissue Biological Implants have become very common. With the advancement in tissue engineering and stem cell research, development of Biological Implants has become much easier.
Global Market Analysis for Biological Implants Growing at a CAGR of XX.XX% for the period 2005 through 2020, North American Biological Implants market is projected to reach about US$ XX.XX billion by 2020 from an estimated US$ XX.XX billion in 2012. European Biological Implants market is projected to reach US$ XX.XX billion by 2020 from an estimated US$ XX.XX million in 2012. European Biological Implants market share is estimated at almost XX.XX % by 2020. Asia-Pacific has the highest CAGR of XX.XX % for the period 2005 through 2020 and the market is projected to reach US$ XX.XX billion by 2020.
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Exhibit 4. Biological Implants– Global Value Market Estimations & Predictions (2005 -2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million Year /Region
North America
Europe
Asia-Pacific
Rest of World
Total
2005
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2006
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2007
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2008
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2009
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2010
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2011
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2012
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2013
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2014
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2015
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2016
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2017
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2018
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2019
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2020
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
CAGR%
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
© RIT Figures, 2013
US$ Million
2005
2006
2007
2008
North America
2009
2010
2011 Europe
2012
2013
2014
2015
Asia-Pacific
2016
2017
2018
2019
2020
Rest of World
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IV. PRODUCT/TECHNOLOGY RESEARCH Cosmetic Surgery Global Market Analysis for Cosmetic Surgery Global Market for Cosmetic Surgery is projected at US$ XX.XX billion by 2020 from US$ XX.XX billion in 2012 with a CAGR of XX.XX % for the analysis period 2005 – 2020. The US is the largest market for cosmetic surgery with a market value of US$ XX.XX billion in 2020 with a market share of XX.XX % globally. Europe is the second largest market with market share of almost XX.XX % in 2010. Rest of World is estimated to have the highest CAGR of XX.XX % and closely followed by AsiaPacific for the analysis period of 2005 – 2020. Exhibit 5. Cosmetic Surgery – Global Value Market Estimations & Predictions (2005 – 2020) in US$ Billion Year
Value
2005
XX.XX
2006
XX.XX
2007 2008
XX.XX XX.XX
2009 2010
XX.XX XX.XX
2011 2012
XX.XX XX.XX
2013 2014
XX.XX XX.XX
2015 2016
XX.XX XX.XX
2017
XX.XX
2018
XX.XX
2019
XX.XX
2020
XX.XX
CAGR%
XX.XX
© RIT Figures, 2013
US$ Billion
2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020
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Orthopedic Biological Implants Bone Graft Substitutes S. No
Substitute
Remark
1
Autologous Growth Factor (AGF) used in combination with autograft & ceramic graft extender.
2
Small pilot Randomized Controlled Trial (RCT) rhBMP-2 used in combination with HA-TCP (V hydroxyapatite comparing rhBMP-2 (bone morphogenetic - tricalcium phosphate) results in higher fusion rates than protein) to autograft for posterolateral autograft. rhBMP-2 may be used as a bone graft substitute fusion.
3
Multicenter RCT comparing rhBMP-2 with rhBMP-2 is a viable alternative to autograft for ALIF with autograft in anterior lumbar interbody fusion titanium cages (ALIF) with specific (LT) cage.
4
Interbody fusions using b2-TCP (supplemented with venous blood only) combined with structural autograft. Fusion considered present in all cases.
β2-TCP may be used as a bone graft substitute in combination with structural allograft & an interbody application of venous blood.
5
Combined analysis of several series comparing rhBMP-2 with autograft for ALIF with specific (LT) cage.
rhBMP-2 is a viable alternative to autograft for ALIF with titanium cages.
6
RCT comparing 3 groups treated with noninstrumented PLF using various mixtures of local autograft & apatite and wollanosite (AWGC)
AWGC acts as an effective bone graft extender when used with local autograft.
Safe when used as a graft extender in lumbar fusions.
© RIT, 2013
BIOLOGICAL IMPLANTS – MARKET OUTLOOK Global Biological Implants market is projected to grow at XX.XX% compounded annually from 2005 through 2020. This growth would be initiated especially by integration of Biological Implants into clinical trials. Biological Implants are expected to increase productivity by identifying potential biological substitutes for the body’s repairable parts. North America, the leading market (XX.XX % of global market share in 2010) for Biological Implants presently is projected to manage the leading position throughout the analysis period with its share dropping to XX.XX % by 2020. Due to the cost advantage and access to the latest technology, Europe is the fastest growing (XX.XX % during 2005-2020) market for Biological Implants which is closely followed by Asia-Pacific. Europe and Asia-Pacific are expected to gain market shares while North America may lose market dominance…………………………
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