About RI Technologies RI Technologies is a premier source of market research on the Biotechnology & Healthcare sector. We emphasize on factual insights and forecasts with maximum global coverage. RI Technologies is constantly monitoring the biotechnology & Healthcare industry, tracking market trends, and forecasting industry based on specialized analysis. The life sciences sector is an ever growing marketplace with emerging technologies in areas of discovery, design and development.
Research – As Good as the Methodology is!
Gauging Competitive Intelligence
Identifying Key Growth Areas and Opportunities
Understanding Geographic Relevance to Product
Knowing Regional Market Sizes and Growth Opportunities and Restraints
Keeping Tab on Emerging Technologies
Equity Analysis
Tapping New Markets
© COPYRIGHT The copyright and publication rights to all RI Technologies' reports and other products are the property of the company. Plagiarism of any kind accounts to violation of copyright laws. Any type of reproduction of the material without express permission is not allowed. The buyer, under no circumstances, shall license, resell or repackage, or sell data without prior permission of the company.
DISCLAIMER RI Technologies sells content in good faith. The company is not liable to the buyer for any implications arising out of the usage of data for any particular purpose. The company makes no representations or warranties for the accuracy or completeness of the data. While extreme caution and effort is practiced for data compilation and presentation, the company does not accept any responsibility for findings in the study which are a cumulative effort of primary and secondary research resources. The studies do not endorse or promote any product or company. RI Technologies, its affiliates, partners, distributors, and contractors are not liable for inaccuracies or incompleteness of the reports. User discretion is recommended for the usage of the data.
RITMIR001: ADME/Tox Technologies – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
Sample Page - 1
I. SCOPE AND METHODOLOGY Scope of the Study This report gives an insight into ADME/Tox technologies. The report covers introduction to ADME/Tox methods including High Throughput Screening and Predictive Technologies such as In vivo, In vitro and In silico. The study includes estimates and projections for the total global ADME/Tox market. Projections and estimates are also illustrated by region and by technology. The report serves as a guide to ADME/Tox industry, as it covers more than 540 companies that are engaged in ADME/Tox studies/screening, products and services. Major Contract Research Organizations serving ADME/Tox industry are also covered in the corporate directory section of this report. Information related to recent product releases, product developments, partnerships, collaborations, and mergers and acquisitions is also covered in the report. This report covers both products and services used in the ADME/Tox industry. Since ADME/Tox is an essential tool in drug discovery procedures, the drug discovery markets are also discussed in brief. Related technologies such as High Throughput Screening (HTS), and cell based assays are also analyzed. This report also attempts a glance at biotechnology industry. ADME/Tox Technologies report is an ideal research tool providing strategic business intelligence to the corporate sector. This report may help strategists, investors, laboratories, pharmaceutical companies, contract research organizations, biotechnology companies and drug approval authorities in understanding the following market factors: •
Comprehending Key Market Drivers
•
Gauging Competitive Intelligence
•
Identifying Key Growth Areas and Opportunities
•
Understanding Geographic Relevance to Product
•
Knowing Regional Market Sizes and Growth Opportunities and Restraints
•
Keeping Tab on Emerging Technologies
•
Equity Analysis
•
Tapping New Markets
Analytics and data presented in this report pertain to several parameters such as – •
Global And Regional Market Sizes, Market Shares, Market Trends
•
Product (Global And Regional) Market Sizes, Market Shares, Market Trends
•
Technology Trends
•
Corporate Intelligence
•
Key Companies By Sales, Brands, Products
•
Consumer Behavioral Patterns
•
Other Strategic Business Affecting Data
RITMIR001: ADME/Tox Technologies – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
Sample Page - 2
Research Methodology RI Technologies publishes business intelligence reports by going through a cycle of diligent research and analysis activity. Research is done using both online and offline resources. The study outline of this report is sketched on the following lines – global market analysis, regional market analysis, product segmentation, global and regional market analysis by product segment, market trends, M&A, R&D, competitive landscape, technology trends, and other key drivers. Current data helps in analyzing the future of the industry and is also helpful for doing market evaluations, and estimating the market size for the future. This report is uniquely researched and the methodology includes: •
Need and Scope of Study
•
Product Definitions
•
Segmental Analysis
•
Regional Analysis
•
Exclusive Data Analytics
•
Corporate Intelligence
•
Feedback
Right from concept to final compilation of this report, both primary and secondary research methods are applied. We have provided exclusive feedback forms/pre-release questionnaires for this report to use the information for authentication of our own findings. Secondary research includes government publications, investment research reports, web based surveys, website information of both companies and markets, and other offline resources such as print publications and CDs. Our compilation of easy to navigate PDF reports are essential value addition resources for leading and growing companies.
RITMIR001: ADME/Tox Technologies – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
Sample Page - 3
II. REPORT SYNOPSIS ADMET technologies play an important role in determining pharmacokinetic and toxicology properties of a new drug candidate in preclinical stage of the drug discovery process. ADME is at present a confirmed and indispensable part of coordinated drug discovery and development programs. It furnishes important data to facilitate iterative chemistry, target discovery and biological procedures on which pipelines are dependent upon. ADME-toxicology is also known as ADMET or ADME/Tox. It is an instrument for drug discovery. It is used for assessing the pharmacological activity or pharmacological toxicity of a drug. It could be performed either in vitro or in vivo. To obtain ADME analysis, the detection systems and assay kits are immensely useful. Presently ADME analysis can also be performed by high throughput automated workstations. Typically ADME/Tox (Absorption, Distribution, Metabolism, Excretion and Toxicology) is defined as follows:
Absorption Absorption determines the compound’s bioavailability. Oral delivery is the most desirable route of drug administration. The effective gastrointestinal absorption of an orally administered drug is one of the key factors for its bioavailability, and the rate of Absorption mainly depends upon the surface area of the intestine.
Distribution Distribution refers to the passage of the drug to the every tissue of the body depending upon the particle size by the process of filtration, diffusion and osmosis. The extent of drug distributed in the body is referred to as Volume of Distribution.
Metabolism The definition of metabolism is the processing of a particular substance inside the living body. Compounds start to disintegrate immediately after entering the living body. A substantial part of the small-molecule drug metabolism is performed within the liver by redox enzymes. These redox enzymes are known as cytochrome P450 enzymes. When the process of metabolism takes place, the original compound which has entered the body, gets transformed into new compounds. The new compounds are called metabolites. The metabolites soon become pharmacologically inactive. At that point in time, metabolism inhibits the dose of the original drug that was dispensed. As this deactivation process advances there is a reduction of the effects on the body. Intermittently, it will be observed, that the metabolites could be pharmacologically active. The metabolites may become more active than the original drug that was administered.
RITMIR001: ADME/Tox Technologies – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
Sample Page - 4
Excretion Excretion or elimination may be described as the process of discharging metabolic waste from the organs, tissues or blood. The compounds and the metabolites of the compounds have to be necessarily eliminated from the body. The process is termed as excretion. The excretion via kidneys is through urine. The waste matter eliminated via the bowels is feces. It is imperative that excretion is thorough. If not, the aggregation of foreign substances tends to negatively affect regular and functional metabolism. Drug excretion takes place via three sites. They are as follows: 1. The most essential site is the kidneys through which drug excretion occurs. The waste matter is eliminated through the urine. 2. Fecal excretion and biliary excretion, that is, relating to bile, is initiated in the liver. The waste matter then is transported through the guts and the last part of the process is the excretion through the feces. 3. The third method of excretion is via the lungs. The lungs are used by the body to eliminate organic anesthetic gases.
Toxicity Toxicity refers to the degree to what extent a substance or matter or the combination of matter can endanger humans. There are two basic toxicities - chronic toxicity and acute toxicity. Chronic toxicity harms over an extended period, is generally repeated and continues. Acute toxicity causes harmful effects over a short period of time.
Significant Methods for ADME/Tox Predictive Technologies Predictive ADME/Tox technologies include:
In Vivo
In Vitro
In Silico
Related ADME/Tox Methods
High Throughput Screening (HTS)
Primary Screening
Secondary Screening
Biochemical Assays
Cell-based Assays
High Content Screening
RITMIR001: ADME/Tox Technologies – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
Sample Page - 5
ADME/Tox Technologies – Global Market Analysis Growing at a healthy compounded annual growth rate (CAGR) of XX.XX % during the analysis period (20052020), global ADME/Tox Technologies market is projected to reach US$ XX.XX billion by 2020 from an estimated US$ XX.XX billion in 2012. Exhibit ADME/Tox Technologies – Global Value Market Estimations and Predictions (2005-2020) in US$ Million Year
Value
2005
XX.XX
2006
XX.XX
2007
XX.XX
2008
XX.XX
2009
XX.XX
2010
XX.XX
2011
XX.XX
2012
XX.XX
2013
XX.XX
2014
XX.XX
2015
XX.XX
2016
XX.XX
2017
XX.XX
2018
XX.XX
2019
XX.XX
2020
XX.XX
%CAGR
XX.XX
© RIT Figures, 2013
RITMIR001: ADME/Tox Technologies – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
Sample Page - 6
In Vitro ADME/Tox – An Emerging Technology In vitro ADME/Tox technologies are likely to have slow development as they have to rely on innovative and new ideas. In vivo methods that have well developed In vivo alternatives are easiest to replace. Other In vivo techniques that provide toxicity information, not easily comprehensible, will be more difficult to replace. The mapping of the human genome and the oncoming of computational techniques has greatly increased the utility of In vitro methods. In vitro technology is largely used to predict whole body kinetics and drug to drug interactions. Factors such as genotypes, age, ethnicity, disease, etc. are taken into consideration to root out potential drug compound failures. Early In vitro toxicity screening helps in eradication of failure compounds very early.
Global Market Analysis The worldwide In vitro ADME/Tox market is estimated at US$ XX.XX million in 2012. Registering a CAGR of XX.XX % during the analysis period, the market is projected to be worth US$ XX.XX million by 2020. With an estimated market share of XX.XX % in 2012, the US represents the largest market for In vitro ADME/Tox with market worth US$ XX.XX million. The US is projected to reach US$ XX.XX million by 2020 by growing at a CAGR of XX.XX % during 2005-2020 to retain the leadership. Canada is expected to be the fastest growing market, while Europe represents second fastest growing as well as second largest market with a share of XX.XX % in 2010.
RITMIR001: ADME/Tox Technologies – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
Sample Page - 7
Exhibit In Vitro ADME/Tox Technologies – Global Value Market Estimations and Predictions (2005-2020) in US$ Million for United States, Europe, Asia-Pacific, Canada and Rest of World Year/Region
United States
Europe
Asia-Pacific
Canada
RoW
Total
2005
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2006
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2007
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2008
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2009
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2010
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2011
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2012
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2013
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2014
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2015
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2016
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2017
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2018
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2019
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2020
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
%CAGR
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
© RIT Figures, 2013
RITMIR001: ADME/Tox Technologies – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
Sample Page - 8
Exhibit List of Major Global In Vivo Companies* Company
Country
Website
ABC Laboratories, Inc.
USA
www.abclabs.com
ADMET Group
USA
www.admetgroup.com
Caliper Life Sciences, Inc.
USA
www.caliperls.com
Charles River Laboratories, Inc.
USA
www.criver.com
Comparative Biosciences, Inc.
USA
www.compbio.com
Eurofins ADME BIOANALYSES
France
www.eurofinsadmebioanalyses.com
GenPharmTox BioTech AG
Germany
www.genpharmtox.de
Gwathmey, Inc.
USA
www.gwathmey.com
Harlan Laboratories, Inc.
USA
www.harlan.com
Nerviano Medical Sciences srl
Italy
www.nervianoms.com
NoAb BioDiscoveries, Inc.
Canada
www.noabbiodiscoveries.com
Pharmaron
USA
www.pharmaron.com
SRI International
USA
www.sri.com
Tetra Q
Australia
www.tetraq.com.au
WuXi AppTec Co., Ltd.
China
www.wuxiapptec.com
Xceleron Ltd.
UK
www.xceleron.com
*Companies Engaged In In Vivo Screening or Products/Services © RIT Figures, 2013
RITMIR001: ADME/Tox Technologies – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
Sample Page - 9
III. MARKET DYNAMICS New technologies in ADME/Tox have evolved from diverse scientific disciplines. The toughest challenge is to integrate several successful features and enable pharmaceutical companies to benefit and reap profits in the future. Though some of the concepts in this industry are still in infant stages, the data generated from other relevant sources can be used to close the gaps. Pharmaceutical companies realize the potential of ADME/Tox technologies and are trying more than before to incorporate innovative procedures to reduce drug attrition rates and lessen the burden of costs and save precious time. Strategic partnerships between pharmaceutical and biotechnology companies are the order of the day, and the trend is increasing globally. Another significant trend is the alliance between Pharma and Biotech companies and information technology companies such as Microsoft, IBM, Oracle, Sun, and Infosys, etc. The computer platforms generated by such companies help managing and analyzing the huge amounts of data produced from ADME/Tox technologies such as High Throughput Screening (HTS) and other computational techniques. Effective R&D strategy involves efficient data management and implementation plans. The new technologies promise improved efficacy, decreased toxicity in patients, and reduced time frames and expenditures. Exhibit ADME/Tox Technologies – Global Value Market Shares (2010, 2015 & 2020) for United States, Europe, Asia-Pacific, Canada and Rest of World Year/Region
United States
Europe
Asia-Pacific
Canada
RoW
Total
2010
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
100
2015
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
100
2020
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
100
© RIT Figures, 2013
RITMIR001: ADME/Tox Technologies – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
Sample Page - 10
Global Pharmaceutical Cell Based Screening Market The size of pharmaceutical cell-based screening market was an estimated US$ XX.XX billion in 2012. This market is expected to reach US$ XX.XX billion by the year 2020 at a CAGR of XX.XX %. Exhibit Pharmaceutical Cell-Based Screening – Global Value Market Estimations and Predictions (20052020) in US$ Billion Year
Value (US$ Billions)
2005
XX.XX
2006
XX.XX
2007
XX.XX
2008
XX.XX
2009
XX.XX
2010
XX.XX
2011
XX.XX
2012
XX.XX
2013
XX.XX
2014
XX.XX
2015
XX.XX
2016
XX.XX
2017
XX.XX
2018
XX.XX
2019
XX.XX
2020
XX.XX
%CAGR
XX.XX
© RIT Figures, 2013
RITMIR001: ADME/Tox Technologies – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
Sample Page - 11
Exhibit Pharmaceutical Contract Research – United States Value Market Estimations and Predictions (2005-2020) in US$ Billion Year
Value (US $ Billion)
2005
XX.XX
2006
XX.XX
2007
XX.XX
2008
XX.XX
2009
XX.XX
2010
XX.XX
2011
XX.XX
2012
XX.XX
2013
XX.XX
2014
XX.XX
2015
XX.XX
2016
XX.XX
2017
XX.XX
2018
XX.XX
2019
XX.XX
2020
XX.XX
%CAGR
XX.XX
© RIT Figures, 2013
RITMIR001: ADME/Tox Technologies – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
Sample Page - 12
Europe trails behind in biotechnology after the United States due to the continent’s several systemic causes, rather than simply institutional failures. Though Europe has many research institutes and universities, the region does not attract foreign investments. European biotechnology industry relies heavily on research done in the US. Exhibit ADME/Tox Technologies – German Value Market Estimations and Predictions (2005-2020) in US$ Million for In Vivo, In Vitro and In Silico Year/Technology
In Vivo
In Vitro
In Silico
Total
2005
XX.XX
XX.XX
XX.XX
XX.XX
2006
XX.XX
XX.XX
XX.XX
XX.XX
2007
XX.XX
XX.XX
XX.XX
XX.XX
2008
XX.XX
XX.XX
XX.XX
XX.XX
2009
XX.XX
XX.XX
XX.XX
XX.XX
2010
XX.XX
XX.XX
XX.XX
XX.XX
2011
XX.XX
XX.XX
XX.XX
XX.XX
2012
XX.XX
XX.XX
XX.XX
XX.XX
2013
XX.XX
XX.XX
XX.XX
XX.XX
2014
XX.XX
XX.XX
XX.XX
XX.XX
2015
XX.XX
XX.XX
XX.XX
XX.XX
2016
XX.XX
XX.XX
XX.XX
XX.XX
2017
XX.XX
XX.XX
XX.XX
XX.XX
2018
XX.XX
XX.XX
XX.XX
XX.XX
2019
XX.XX
XX.XX
XX.XX
XX.XX
2020
XX.XX
XX.XX
XX.XX
XX.XX
%CAGR
XX.XX
XX.XX
XX.XX
XX.XX
© RIT Figures, 2013
RITMIR001: ADME/Tox Technologies – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
Sample Page - 13
IV. PRODUCT/TECHNOLOGY RESEARCH Time and Money – both can be be saved by applying ADME/Tox technologies in the early drug discovery processes. ADME/Tox studies determine dosage and toxicity issues for any new drug before human trials. Prediction of potential human risks of a new drug candidate is crucial in early stages of the drug discovery/development process. Even 10%-12% increase in identifying failures before a drug candidate entering the clinical trial stage could save the company over US$100 million. ADME/Tox or ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) is widely accepted preclinical testing system of a new drug candidate. ADME/Tox is applied in various tests to determine the candidate’s characteristics such as absorption, distribution, metabolism, and excretion respectively by intestine, liver, kidney, and other target organs. ADME/Tox is also applied in determining toxicity profile of the drug candidate. Biotechnology methods for screening new drug candidates are becoming important and the technology needs to provide latest screening tools at the pace of discovery of numerous new drug candidates. Improvements in molecular biology made it possible to clone express proteins that are expected to play a key role in disease trial; and combinatorial chemistry helped in creating large libraries of chemical compounds. This phenomenon helped in discovering/identifying huge number of drug candidates. Though animal studies, considered as gold standard in confirming adequate drug exposure limits in human are essentially used in tests, non animal models such as In vitro and In silico techniques are rapidly making their ground. Most of the drugs fail in the clinical development phase due to their poor ADME/Tox properties. Companies are making robust efforts in eliminating poor elements before they enter into clinical trials. Drug failure in or post clinical trial phase may lead the company into economic disasters.
RITMIR001: ADME/Tox Technologies – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
Sample Page - 14
Exhibit Drug Development Cost - Estimations and Predictions (2005-2020) in US$ Million Year
Pre-Clinical
Phase I
Phase II
Phase III
Total
2005
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2006
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2007
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2008
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2009
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2010
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2011
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2012
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2013
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2014
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2015
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2016
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2017
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2018
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2019
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
2020
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
CAGR%
XX.XX
XX.XX
XX.XX
XX.XX
XX.XX
© RIT Figures, 2013
(Pre-Clinical Includes Discovery to Pre-Clinical Development)
RITMIR001: ADME/Tox Technologies – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
Sample Page - 15
Exhibit Reasons for Drug Failure in Clinical Trials in Phase I –III Reason
Phase I
Phase II
Phase III
Pharmacokinetics
15%
18%
6%
Human Toxicity
40%
27%
32%
Efficacy Not Proven
32%
38%
49%
Economic
2%
4%
5%
Other
11%
13%
8%
Total
100%
100%
100%
(Other Includes Chemistry (Unknown), Improved Candidate, Commercial) © RIT Figures, 2013
(Other Includes Chemistry (Unknown), Improved Candidate, Commercial)
RITMIR001: ADME/Tox Technologies – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
Sample Page - 16
Analysis by Segment Exhibit In Silico ADME/Tox – Global Value Market Estimations and Predictions (2005-2020) in US$ Million for Organ and Tissue Cells, Cellular Networks, and Whole Cells Year/Segment
Organ & Tissue Cells
Cellular Networks
Whole Cells
Total
2005
XX.XX
XX.XX
XX.XX
XX.XX
2006
XX.XX
XX.XX
XX.XX
XX.XX
2007
XX.XX
XX.XX
XX.XX
XX.XX
2008
XX.XX
XX.XX
XX.XX
XX.XX
2009
XX.XX
XX.XX
XX.XX
XX.XX
2010
XX.XX
XX.XX
XX.XX
XX.XX
2011
XX.XX
XX.XX
XX.XX
XX.XX
2012
XX.XX
XX.XX
XX.XX
XX.XX
2013
XX.XX
XX.XX
XX.XX
XX.XX
2014
XX.XX
XX.XX
XX.XX
XX.XX
2015
XX.XX
XX.XX
XX.XX
XX.XX
2016
XX.XX
XX.XX
XX.XX
XX.XX
2017
XX.XX
XX.XX
XX.XX
XX.XX
2018
XX.XX
XX.XX
XX.XX
XX.XX
2019
XX.XX
XX.XX
XX.XX
XX.XX
2020
XX.XX
XX.XX
XX.XX
XX.XX
%CAGR
XX.XX
XX.XX
XX.XX
XX.XX
© RIT Figures, 2013
RITMIR001: ADME/Tox Technologies – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
Sample Page - 17
RITMIR001: ADME/Tox Technologies – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
Sample Page - 18
ADME/TOX TECHNOLOGIES – THE OUTLOOK Global ADME/Tox Technologies market is projected to grow at a robust rate of XX.XX % compounded annually from 2005 through 2020. This growth is mainly driven by the efforts of pharmaceutical and biotech companies for reducing time and cost of drug discovery. ADME/Tox profiling of a drug candidate plays a key role in reducing clinical trials cost and time of drug launch to the market. ADME/Tox assays eliminate compounds with lack of bioavailability, lower efficacy and toxicity in early stages, in order to save time and costs in expensive later stages of drug discovery. Due to ethical issues and growing trend towards decrease in using animals in clinical trials, there is a gradual decline in market for In vivo predictive technology. Though In vivo accounts for about three- fourth of total ADME/Tox Technologies market currently, non-animal technologies- In vitro and In silico are projected to peg more than 40% of the market by 2015. In particular, In silico is projected grow at a high CAGR of XX.XX % during the period 2005-2020. In terms of technology, In silico is projected to register the fastest growth rate in all geographic markets……………………………...
RITMIR001: ADME/Tox Technologies – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com
Sample Page - 19