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HowSunitinibMalateWorks?
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Sunitinib Malate is used to treat a rare cancer of the stomach, bowel, or esophagus called gastrointestinal stromal tumor (GIST) and when you have taken the medicine imatinib mesylate and it did not stop the cancer from growing or you cannot take imatinib mesylate.
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Gleevec is a registered trademark of Novartis Pharmaceuticals Corporation.
Sunitinib Malate is used to treat a type of pancreatic cancer known as pancreatic neuroendocrine tumors (pNET) that has progressed and cannot be treated with surgery.
How Sunitinib Malate Works?
Sunitinib Malate is a small-molecule inhibitor of multiple receptor tyrosine kinases, some of which are implicated in tumor growth, pathologic angiogenesis, and metastatic progression of cancer. The agent inhibits platelet-derived growth factor receptors -(PDGFRα and PDGFRβ), vascular endothelial growth factor receptors (VEGFR1, VEGFR2, and VEGFR3), stem cell factor receptor (KIT), FMS-like tyrosine kinase 3, colony-stimulating factor receptor type 1, and the glial cell-line derived neurotrophic factor receptor (RET). Sunitinib Malate inhibition of the activity and function of these receptor tyrosine kinases has been demonstrated in biochemical and cellular assays and cell proliferation assays. The primary metabolite of Sunitinib Malate exhibits potency similar to the parent compound in biochemical and cellular assays.
Sunitinib Malate inhibits phosphorylation of multiple receptor tyrosine kinases (PDGFRβ, VEGFR2, KIT) in tumor xenografts expressing receptor tyrosine kinase targets in vivo and inhibits tumor growth and metastasis in some experimental models. The agent inhibits growth of tumor cells expressing dysregulated target receptor tyrosine kinases
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