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From Reddit & Quora: 12 Questions(Hotly Debated) About NMN(2)
What Benefits Can NMN Powder Bring To My Body? NMN (Nicotinamide Mononuleotide) is a natural precursor of NAD+. NMN supplementation raises DAN+ for essential health & longevity amongst providing other health benefits.NMN powder is in the early stages of human trials and the current benefit claims have been through the success of animal studies. To date, there is no evidence of any adverse effects, even at high doses over a prolonged period of time. It has also shown health benefits in cases of Type II Diabetes and Alzheimer’s Disease.Below are 10 of the top benefits of NMN powder: ♦ Anti-Aging effect ♦ Increases fertility in women ♦ Improves eyesight & vision ♦ Energy booster ♦ Facilitates the repair of broken DNA strands ♦ Improves kidney function & blood flow ♦ Lowers cholesterol & triglycerides ♦ Improves Immune system function 1
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♦ Promotes heart health & function ♦ Improves mitochondrial function by reducing neuroinflammation
Can I Get Enough NMN From Food To Anti-aging? The answer is “of course not”. Because NMN is found naturally in many foods and you can easy to find them in our life.Below are the six foods highest in NMN: Broccoli Cabbage Cucumber Edamame Avocado Tomato
Now, you must be thinking: “If NMN is found in food, can’t I increase my levels of NAD+ by eating more of those foods?” That’s a good question. However, I should point out that if you want to reverse aging 2
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with NMN, you will have to eat large amounts of each of these foods. Sadly, the NMN in a few stems of broccoli is hardly enough to even begin to boost NMN levels.Although NMN occurs in these foods, the concentrations are less than 1 mg per kg of food. In other words, to get about 1mg of NMN, you’d have to eat about 1kg of broccoli!It’s been found that to boost the levels of NAD+ in humans, the levels of NMN should be in the hundreds of milligrams per dose. This is way higher than what we can get from our diets, no matter how much broccoli we eat. So, we must consider about taking NMN powder as supplements to anti-aging in our life, it can help our body increase more NAD+, fighting aging.
How To Take NMN Powder? In last question, we mentioned Dr. David Sinclair who has taken 1g NMN every day. Then 1g be the most effective dosage for us to get the benefits of NMN, right? “Certainly not!” When working out how much you need to take, it’s important to consider how the NMN is administered and its bioavailability. What’s more, different body with different reaction. We need make out when it is good to take NMN, how to take it and how much dose we should take when you ready to take NMN powder.
Let us talk the first question: How To take NMN powder? NMN is administered in four options that will affect how much NMN actually makes it into your blood system: powder, sublingual powder, standard capsules, and gastric-resistant capsules. To understand bioavailability, one has to understand the First Pass Effect(it refers to how much of a substance is destroyed or processed by the liver before it actually passes into the blood system). This is the complicated concept, I guess this video can help us to understand how it works and why it is very important for us to know it before taking NMN powder. Because of the first-pass metabolism, oral consumption of NMN is much less effective than sublingual or 3
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gastro-resistant capsules. When NMN powder is taken orally (either when eaten or mixed with a liquid) most of it is destroyed by the stomach acid. The remaining NMN is then metabolized by the liver. How the liver metabolizes NMN can have a huge impact on bioavailability. It may be that only a fraction of NMN actually makes it into your system. Also to improve your NAD+ levels, you can take the delayed-release NMN capsules with a Sirtuin Activator such as a Resveratrol with a full-fat yogurt which helps the bioavailability of Resveratrol. But when NMN (or any medication or supplement) is taken sublingually, it is absorbed across the mucous membranes (under the tongue) and passes directly into the bloodstream. From there it travels straight to the brain and other organs, bypassing the “first pass effect” from the liver. It is for this reason, that we believe taking sublingual NMN or in a gastric-resistant capsule is the most effective and efficient. It may require lower doses than taking NMN powder orally or in standard capsule form.
The next question: When it is best time to take NMN powder? Aging is a disease that can be fought with the appropriate combinations of supplements and behaviours, according to new research from the University of Waterloo.Using a comprehensive mathematical model, the researchers also found that the best time of day for someone to take these supplements depends on their age. Some anti-aging supplements should be taken by young people at night, while older people should take it midday for the greatest effectiveness.“The time you eat, what you eat, the time you sleep and the time you exercise are all factors that can affect your body, how you age and how you live,” Researcher Layton said. “People should be mindful of when they eat and ensure that it coincides with other things in their environment that impact their sleep/wake cycle or body clock. So, when it is best time to take NMN powder? age is the main factor before deciding to how much we take NMN powder. For example, it was studied that NMN supplements are most beneficial for young people to take six hours after waking up. On the contrary, studies 4
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show that Resveratrol supplements work best if young people take them in the afternoon. For older adults, it is important to take these supplements in the afternoon.
The last question: How much we should take NMN powder? After we read the above questions, we must know that every one need find own dosage for NMN powder, not an exact dose as recommendation. Then how can we calculate the NMN dosage for ourselves? As the latest studies, it is related with our weight. From the study: “Given that 100 mg/kg/day of NMN was able to mitigate most age-associated physiological declines in mice, an equivalent surface area dose for humans would be ~8 mg/kg/day, providing hope to translate our findings to humans.” According to the authors of a recent research study, is to take a bare minimum of 8 mg of NMN per kg of body weight per day. If the study are correct, then to find how much NMN you need at the minimum, you would first need to find your weight in kg, then multiply by 8. For example, if your weight is 50kg, the recommended dosage is about 400mg. If you take a high-quality supplement with excellent bioavailability, like AASraw’s NMN powder, then we recommend the following dosages that are based on customer feedback: Weight Dosage For Reference (daily) 45kg 45kg * 8mg = 360mg 50kg 50kg * 8mg = 400mg 60kg 60kg * 8mg = 480mg 70kg 70kg * 8mg = 560mg 90kg 90kg * 8mg = 720mg These dosage is only as refence. How much should you take? It’ s up to you. But if you find this particular study convincing, you might to begin your calculations at 8 mg per kg of body weight per day.
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