www.aasraw.com
Testosterone cypionate raw powder： Everything you should know about the amazing steroids!!!(1)
Testosterone cypionate raw powder：Everything you should know about the amazing steroids!!!.............1 ǀ.Testosterone Cypionate basic Characters:........................................................2 What is Testosterone cypionate?/Testosterone cypionate overview...............2 History of Testosterone Cypionate........................................................................ 3 What is Testosterone cypionate raw powder?.....................................................4 What form(s) does Testosterone cypionate raw powder come in?..................5 How does Testosterone cypionate work?.............................................................5 Mechanism of Action........................................................................................6 Pharmacokinetics:............................................................................................6 Potential benefits of Testosterone Cypionate...................................................... 7 How should I use Testosterone Cypionate ?....................................................... 8
1
AASraw Biochemical Technology Co.,Ltd aas14@aasraw.com
www.aasraw.com
ǀ.Testosterone Cypionate basic Characters: Name:
Testosterone Cypionate
CAS:
58-20-8
Molecular Formula: C27H40O3 Molecular Weight:
412.6
Melt Point:
98 – 104ºC
Storage Temp:
2-8ºC
Color:
White or off white Crystal Powder
What is Testosterone cypionate?/Testosterone cypionate overview Testosterone Cypionate is one of the many esterified variants of Testosterone available,usually for bodybuilding and treating ED,others like Testosterone acetate,Testosterone decanoate, Testosterone enanthate,Testosterone phenylpropionate,Testosterone isocaproate,Testosterone propionate,Testosterone Sustanon 250,are all part of the variants of Testosterone. Testosterone Cypionate is most likely the second most popular esterified variant (the first being Testosterone Enanthate). It is an injectable form of Testosterone with a slow rate of release and a longer half-life. However, the release rates and half-life of both Testosterone Cypionate and Testosterone Enanthate are very much identical and the two compounds are easily interchangeable (for example, an individual can easily run a 10 week cycle of Testosterone and switch between Testosterone Enanthate and Testosterone Cypionate seamlessly). Testosterone Cypionate possesses a half-life of approximately 12 days while Testosterone Enanthate possesses a half-life of approximately 10 days – hardly much difference. The interesting fact about Testosterone Cypionate, however, is that it seems to have a distinct favor of popularity among American bodybuilders and athletes over the Enanthate variant. These distinctions are not extreme, however, and the commonality of use and availability of both variants is almost equal with Testosterone 2
AASraw Biochemical Technology Co.,Ltd aas14@aasraw.com
www.aasraw.com
Enanthate ever so slightly more popular. Neither variant possesses any advantages over the other.
History of Testosterone Cypionate Testosterone Cypionate was first created in the mid-1950s, and was released on the prescription drug market under the brand name Depo-Testosterone and manufactured by UpJohn (however, its brand name at first was labeled as Depo-Testosterone cyclopentylpropionate but was shortened for obvious reasons). Unlike Testosterone Enanthate, which is primarily known as an international item, Testosterone Cypionate is known to be the US answer to the Enanthate variant (although Testosterone Enanthate is utilized almost just as equally in the US). Testosterone Cypionate has held such a positive track record that it is in fact still in production by Upjohn (who merged with Pfizer in 2009) today. As Testosterone Cypionate was the American response to the international product Testosterone Enanthate, many American bodybuilders and athletes throughout the 1960s, 70s, and 80s preferred the use of Testosterone Cypionate over the Enanthate variant for no reason other than the support of an American product, very much akin to an issue of pride (once again, the Cypionate and Enanthate variants of Testosterone are both almost 100% identical and there is no practical reason to prefer one compound over the other). Testosterone is the primary androgen found in the body. Endogenous testosterone is synthesized by cells in the testis, ovary, and adrenal cortex. Therapeutically, testosterone is used in the management of hypogonadism, either congenital or acquired. Testosterone is also the most effective exogenous androgen for the palliative treatment of carcinoma of the breast in postmenopausal women. Testosterone was in use in 1938 and approved by the FDA in 1939. Anabolic steroids, derivatives of testosterone, have been used illicitly and are now controlled substances. Testosterone, like many anabolic steroids, was classified as a controlled substance in 1991. Testosterone is administered parenterally in regular and delayed-release (depot) dosage forms. In September 1995, the FDA initially approved testosterone transdermal patches (Androderm); many transdermal forms and brands are now available including implants, gels, and topical solutions. A testosterone buccal system, Striant, was FDA approved in July 2003; the system is a mucoadhesive product that adheres to the buccal mucosa and provides a controlled and sustained release of testosterone. In May 2014, the 3
AASraw Biochemical Technology Co.,Ltd aas14@aasraw.com
www.aasraw.com
FDA approved an intranasal gel formulation (Natesto). A transdermal patch (Intrinsa) for hormone replacement in women is under investigation; the daily dosages used in women are much lower than for products used in males. The FDA ruled in late 2004 that it would delay the approval of Intrinsa women’s testosterone patch and has required more data regarding safety, especially in relation to cardiovascular and breast health.
What is Testosterone cypionate raw powder? Testosterone cypionate raw ,the raw material of drug Testosterone cypionate,is a kind of White or off white Crystal Powder,odorless or nearly so and stable in air. It is insoluble in water, freely soluble in alcohol, chloroform, dioxane, ether, and soluble in vegetable oils.Many bodybuilding supplement supplier usually buy high purity Testosterone cypionate raw powder,then make it into finished one. Detail of Testosterone cypionate raw powder as below: Name: Testosterone Cypionate CAS: 58-20-8 Molecular Formula: C27H40O3 Molecular Weight: 412.6 Melt Point: 98 – 104ºC Storage Temp.: 2-8ºC Color: White or off white Crystal Powder
4
AASraw Biochemical Technology Co.,Ltd aas14@aasraw.com
www.aasraw.com
What form(s) does Testosterone cypionate raw powder come in? Testosterone Cypionate raw powder is commonly used as an injected oil,also sold in the form of injection.In the market, there are 200mg/ml, 250mg/ml, 300mg/ml, some UGL even made 350mg/ml and 400mg/ml.
How does Testosterone cypionate work? Testosterone cypionate belongs Testosterone,is the class of medications called androgens (male hormones). This medication is used to replace testosterone in men who have conditions caused by low testosterone levels, such as erectile dysfunction (difficulty getting or keeping an erection). There are other possible causes for erectile dysfunction, so testosterone is only used to treat erectile dysfunction that is caused by low testosterone.
5
AASraw Biochemical Technology Co.,Ltd aas14@aasraw.com
www.aasraw.com
Testosterone cypionate works by replacing the testosterone that the body is missing. Testosterone cypionate should only be used if testosterone deficiency has been confirmed by symptoms and blood tests.
Mechanism of Action
Endogenous testosterone is responsible for sexual maturation at all stages of development throughout life. Synthetically, it is prepared from cholesterol. The function of androgens in male development begins in the fetus, is crucial during puberty, and continues to play an important role in the adult male. Women also secrete small amounts of testosterone from the ovaries. The secretion of androgens from the adrenal cortex is insufficient to maintain male sexuality. Increased androgen plasma concentrations suppress gonadotropin-releasing hormone (reducing endogenous testosterone), luteinizing hormone, and follicle-stimulating hormone by a negative-feedback mechanism. Testosterone also affects the formation of erythropoietin, the balance of calcium, and blood glucose. Androgens have a high lipid solubility, enabling them to rapidly enter cells of target tissues. Within the cells, testosterone undergoes enzymatic conversion to 5-alpha-dihydrotestosterone and forms a loosely bound complex with cystolic receptors. Androgen action arises from the initiation of transcription and cellular changes in the nucleus brought about by this steroid-receptor complex. Normally, endogenous androgens stimulate RNA polymerase, resulting in an increased protein production.These proteins are responsible for normal male sexual development, including the growth and maturation of the prostate, seminal vesicle, penis, and scrotum. During puberty, androgens cause a sudden increase in growth and development of muscle, with redistribution of body fat. Changes also take place in the larynx and vocal cords, deepening the voice. Puberty is completed with beard development and growth of body hair. Fusion of the epiphyses and termination of growth is also governed by the androgens, as is the maintenance of spermatogenesis. When endogenous androgens are unavailable, use of exogenous androgens are necessary for normal male growth and development.
Pharmacokinetics: 6
AASraw Biochemical Technology Co.,Ltd aas14@aasraw.com
www.aasraw.com
Testosterone is administered intramuscularly (IM), to the skin as a topical gel, solution, ointment or transdermal systems for transdermal absorption, by implantation of long-acting pellets, or via buccal systems. Testosterone is administered intramuscularly (IM); via subcutaneous injection; to the skin as a topical gel, solution, ointment or transdermal systems for transdermal absorption; by implantation of long-acting pellets, or; via buccal systems. In serum, testosterone is bound to protein. It has a high affinity for sex hormone binding globulin (SHBG) and a low affinity for albumin. The albumin-bound portion freely dissociates. The affinity for SHBG changes throughout life. It is high during prepuberty, declines during adolescence and adult life, then rises again in old age. The active metabolite DHT has a greater affinity for SHBG than testosterone. Elimination half-life is 10—100 minutes and is dependent on the amount of free testosterone in the plasma. Testosterone is metabolized primarily in the liver to various 17-keto steroids. It is a substrate for hepatic cytochrome P450 (CYP) 3A4 isoenzyme.1 Estradiol and dihydrotestosterone (DHT) are the major active metabolites, and DHT undergoes further metabolism. Testosterone activity appears to depend on formation of DHT, which binds to cytosol receptor proteins. Further metabolism of DHT takes place in reproductive tissues. About 90% of an intramuscular testosterone dose is excreted in the urine as conjugates of glucuronic and sulfuric acids. About 6% is excreted in the feces, largely unconjugated. There is considerable variation in the half-life of testosterone as reported in the literature, ranging from 10 to 100 minutes.2 Affected cytochrome P450 isoenzymes and drug transporters: CYP3A4, P-gp. Testosterone is a substrate for CYP3A4 and is also both transported by and an inhibitor of P-glycoprotein (P-gp) transport.
Potential benefits of Testosterone Cypionate The purpose of Testosterone Cypionate injections is to help regulate male hormone levels to help address problems related to low T. For men with low 7
AASraw Biochemical Technology Co.,Ltd aas14@aasraw.com
www.aasraw.com
T or for Testosterone Cypionate bodybuilding, the benefits of Testosterone Cypionate injections can include: 1. 2. 3. 4. 5. 6. 7. 8. 9.
an increased sex drive improved symptoms of ED more energy improved mood an increased sperm count Maintain muscle strength and quality Maintain bone density and strength Maintain libido and erections Energizing and improving your fitness
How should I use Testosterone Cypionate ? Testosterone Cypionate doses are very flexible in terms of the user’s goals in question. Testosterone Cypionate doses can be tailored to any possible goal – cutting, bulking, lean mass cycles all alike. Variation between Testosterone 8
AASraw Biochemical Technology Co.,Ltd aas14@aasraw.com
www.aasraw.com
Cypionate doses depending on the user’s goal.For example, the bodybuilding ranges of doses are generally required for an individual that wishes to bulk up
or add lean mass. For the purpose of cutting and fat loss, it is generally not a requirement to venture very high in dose ranges due to the fact that the primary concern when engaging in fat loss is the preservation of muscle mass during a caloric deficit in which muscle loss is a risk without the use of anabolic steroids. In such a case, lower doses are usually all that is necessary.
9
AASraw Biochemical Technology Co.,Ltd aas14@aasraw.com
