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There was another study that was performed with the purpose of determining the effect of Urolithin A on muscle strength and endurance in the elderly, who experience a decrease in mitochondrial activity with age. According to the researchers performing the clinical trial, there was a resolution of failing mitophagy amongst the participants of the study, indicating the clearance of dysfunctional mitochondria and improvement of mitochondrial health overall. Compared to the group that received placebo, the participants given the Urolithin A supplement reported significant improvement of endurance and strength of muscles in legs and arms. There was reduced fatigue and an overall improvement in the ability to perform daily functions. Researchers also noted that the Urolithin A supplement could be an alternative method of improving muscle strength and stamina amongst elderly individuals who cannot perform exercise due to physical or mental health issues. According to the Center for Disease Control and Prevention or CDC, daily exercise can help combat mobility issues, fall risks, and other movement disorders in the elderly. However, when this isn’t possible, taking Urolithin A supplements can bring mitophagy to normal levels, hence, having the same effect as exercise.
❷ Management of Duchenne Muscular Dystrophy However, with degenerative muscular diseases such as Duchenne Muscular Dystrophy or DMD, the mitochondrial content of the cells is defective and the mitochondria present do not function properly. Moreover, in DMD, mitophagy is significantly reduced, which is a process through which our bodies remove dysfunctioning mitochondria and recycle the content to meet the high energy demands of the body. One of the researches conducted to study the effects of Urolithin A powder on muscle growth focused on the effect the former has on mitophagy. Researchers found that supplementation with Urolithin A significantly improved the mitophagy levels, returning them back to normal in muscular dystrophy patients. These results were seen on both animal models and human subjects, indicating that Urolithin A can be successfully used to manage the symptoms of muscular dystrophies. Moreover, researchers recorded a whopping 40 percent increase in survival rates of animal models given the Urolithin A supplement compared to those who didn't receive the supplement. The grip strength and running strength increased by 31 percent and 45 percent, respectively, in these animal models. Another important benefit of Urolithin A supplementation that was noticed during this study was that it reduced fibrosis or scarring of the heart and diaphragm of the mice 7
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