Contents > Blister Packing
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> Pot and Bottle Filling
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> Sachet Filling
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> Peel Pouch Packing and Assembly
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> Multivac Thermoforming Technology > Cleanroom Facility
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> Medical Device Packing and Assembly 11
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> General Re-work and Embellishment
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> Serialisation
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> Artwork, Origination and Pre-Press
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> Packaging Design and Sampling
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> Digital Printing
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> Digital Braille
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> Cartons and Leaflets
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> Research, Development and Manufacturing
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> 3D Professional Research and Industrial Design
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> Location Map and Contacts
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A Unique Resource for the Pharmaceutical & Healthcare Sectors Chester Medical Solutions offers a unique service to the UK’s Pharmaceutical and Healthcare industries. With a 50 year history of providing flexible, innovative and cost-effective solutions to challenging briefs, we have established ourselves as a valuable partner to ethical, generic, OTC, nutritional, diagnostic and medical device brand owners. Our GMP Contract Packing Division is fitted out to the highest standards and provides a comprehensive range of services. Dedicated suites contain processes such as blister packing, pot, bottle and sachet filling as well as medical device manufacture, assembly and liquid filling. We also offer re-work and embellishment services. Our certified cleanroom environments run from ISO 7 down to ISO 5 and the facility is MHRA approved and ISO13485 registered. Additionally we have humidity control and standard clean environments available. Other accreditations include clinical trials, veterinary, specials, wholesale distribution and soil association licences.
At our PS9000 approved Carton and Leaflet facility we offer a range of printed packaging services including graphic design, artwork and origination services, CAD sampling, conventional and digitally printed cartons and leaflets. Our digitally printed cartons and leaflets cater to the industry’s increasing demand for short run, short lead-time manufacture. We were the first UK carton manufacturer to offer digitally printed cartons with digital Braille. The fact that our digital facility is one of the few (if not the only) in the UK to be PS9000 accredited is an additional bonus to our Pharmaceutical clients. Our sister company Quay Pharma is one of the world’s leading Contract Development, Manufacturing and Packaging Organisations. Quay provides specialist services to the pharmaceutical and biotech industries built on our unique expertise in pharmaceutical development, analytical services and contract manufacturing for clinical and specials products.
Accreditations: > MHRA Licence > ISO9001:2015 (Bromborough and Deeside Sites) > ISO13485 - Medical Devices > Distribution Licence > Veterinary Licence > Specials Licence > Soil Association Licence > PS9000 - Cartons & Leafets > BCMPA Member
Our Markets Include: > > > > > > >
Pharma Healthcare Medical Devices Diagnostics Nutrition VMS Veterinary
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Blister Packing Using Noack 623 Blister Lines with in-line Hapa foil printers, image detection, automatic cartoning and banding, we pack a variety of solid dosage forms into thermo formed or cold form blisters.
Dosage forms:
Blister materials:
> Tablets
> PVC & PVDC
> Caplets
> Triplex
> Capsules
> Aclar
> Soft gel capsules
> Cold form
> Liquids
> Child resistant
Our cold form line has colour camera detection and a tear check system. The packing environment is temperature and humidity controlled. 5
Pot and Bottle Filling We provide accurate dispensing of various size and shape tablets, caplets, capsules, soft gel capsules or powders.
Complete with in-line capping, induction seal, labelling, coding and cartoning, including the insertion of patient information leaflets. Products can be packed into glass or plastic bottles, containers with child- resistant/seniorfriendly caps or a variety of flexible plastic foils and laminate sachets Air handling systems and on-line dust extraction ensure an optimal packing environment. 6
Sachet Filling We also pack a variety of solid dose and powder products into a range of sachets using 4 sided seal machinery on various substrates ranging from clear films to Aluminium style foils.
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Peel Pouch Packing and Assembly Using Doyen Technology – 4 side seal packing machinery, we offer a variety of pouching and assembly solutions.
Peel pouch packing includes: > Wound care dressings > Hospital ancillaries > Medical devices
Dressings and devices are packed in a large ISO Class 7 environment with the option of terminal sterilisation.
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Multivac Thermoforming Technology Our Multivac R140 Thermoformer gives us the ability to pack a wide range of medical and diagnostic devices into flexible, deep draw blister packs with peelable lids. The lids can be formed from paper, Tyvek or laminate materials.
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Cleanroom Facility Our 1600 sq.ft. cleanroom facility offers an ISO Class 7 environment for either medical device or pharmaceutical production and assembly.
Features include: > 1600 sq.ft. of floor space > Interlocking materials movement area > Integral change facility > Step over and hand sanitisation units > High pressure melamine laminate surface finish > Perfectly coplanar walls, doors and windows > Air handling system with temperature and humidity control > Modular construction for future expansion > Laminar flow cabinet to achieve ISO Class 5 environment
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The air handling system supplies 20 air changes per hour through pre-bag and hepa filters and also controls temperature and humidity. The modular design incorporates a high pressure melamine laminate that is easily maintained to cleanroom standard.
Medical Device Packing and Assembly We pack the following: > Burns & wound care dressings > Medical device kits > Tubing > Hospital kits
Foam can also be die cut to hold ampoules and syringes. We also offer cellophane over-wrapping with tear tape option. If required we can validate and manage terminal sterilisation.
> Diagnostic devices > Pregnancy test kits > Blister packing > Fixation devices
Primary packing can be carried out in our cleanroom or in one of our dedicated packing suites. The product can be packed into trays, pouches, bags or flow-wrap or as part of a KIT that is packed into a carton. 11
General Re-work and Embellishment Secondary Packaging
Rework (Packed Product)
We have the flexibility to re-dress and re-present product in a variety of formats, providing full batch traceability where required.
When the MHRA or a customer requires changes to an already packed product, we can carry out a rework maintaining full batch integrity.
Our fast and efficient service recognises the commercial pressures often present for re-work.
> Replacement of a carton or leaflet
Our In-house services include:
> Reconfiguration of Pack Presentations
> Re-work – removing/replacing cartons or leaflets with full batch integrity
Embellishment
> Over-labelling including small vials > Shelf ready packing (SRP) > Clip strips > Collating various items into a KIT format > Over-wrapping > Promotional multi-packs > Kit Assembly > Late stage customisation 12
> Over-labelling of a bottle using block out style material
Embellishment is when a product is put into a secondary piece of packaging used for an impulse buy or as a requirement of a supermarket. > SRP packing > CDU packing > Till toppers > Floor standing display units > Clip Strips
Serialisation Our serialisation solution is based around the XMV TE Track & Trace technology. The advanced inspection system which integrates three processes; combining ink jet printing and image verification with secure, tamper-evident sealing. The system is in compliance with EU delegated act 2011/62/EU and EN 16679 enabling us to offer fully compliant serialisation solutions to our clients, including full aggregation and the ability to re-work previously serialised product.
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Artwork, Origination and Pre-Press Services Artwork and Origination Studio From concept to completion our team of in-house pre-press specialists are at your service to ensure your product is given real brand value and prominence in a crowded market place. Whether it be a brand extension, amending your existing artwork or preparing files for press, our experienced studio team are ready to step in at any stage. Be assured that because we specialise in Pharma, all of our designs strive to meet MHRA and NPSA guidelines, ensuring end user safety and ease of use. We know print too, so you can be sure our creative ideas will be developed into print ready files that always work on press, whether it be litho or digital.
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Our combination of technology, creativity and highly knowledgeable staff, means whatever your brief, we aim to engage, innovate and deliver on time, every time, helping you achieve results that are second to none.
Packaging Design and Sampling Service Carton Design and Sampling Our in-house packaging design facility is ideal for developing all your carton concepts as well as producing one-off pre-production samples, product sizing, material testing and digitally printed mock ups. Our specialist CAD Operators can design and plot bespoke packaging to meet your customers everyday challenging requirements. The samples can be produced on a variety of board substrates from folding box boards to white lined chip board to Kraft materials or micro-flutes. Samples can be simple RTE cartons to complex cartons with internal fitments or blister wallets. Using 3D visual software on the CAD system, allows our customers to see a 3D computer
generated image of the carton before receiving a sample. Complemented with our in-house graphic design and digital print service makes Chester Medical a truly unique package.
Our in-house CAD CAM service includes: > 2D die line drawing creation > CAD sampling from a variety of substrates > Full scale carton profiles > 3D carton visualisation prior to sampling > 1000’s of standard carton designs that can be created quickly using our parametric library 15
In-house Digital Printing Facility Our in-house digital printing facility is fast, flexible and cost effective. Ideal, not only for short run, quick turnaround jobs but also for high quality registration samples and ‘start up’ quantities
Our Digital Printing Service offers: > 3 digital packaging and leaflet presses > Pira tested print durability > Variable text and images > Full personalisation > Kit Assembly > Late stage customisation > Security systems > Cartons and leaflets – stock 60-350 gsm > Sequential numbering > Barcode scanning
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Fast Outputting directly from computer to press eliminates many of the time consuming processes associated with traditional litho.
Flexible It’s not just cartons and leaflets, there are literally hundreds of possibilities with digital print, all customisable with variable data text and images, making direct marketing easy, flexible and effective.
Cost Effective Short runs means lower costs and because you only print what you need, you only pay for what you need.
> Full colour large format printing
Durable
> No plate or origination costs
PIRA tested print durability.
In-house Digital Braille Facility Chester Medical Solutions is the FIRST carton manufacturer to offer digital Braille. Our ÂŁ150,000 investment allows the printing of Braille dots onto a carton without the need for special tooling, making it ideal for short runs and digitally printed cartons.
It is installed in our PS9000 certified digital production suite at our carton and leaflet manufacturing facility.
The system uses a polymer ‘drop on demand’ nozzle to apply the Braille, which is then UV cured. After application, a vision verification system checks each carton for dot presence, height and circumference, and translates the Braille into human readable text for operators to check. Print quality and resolution are excellent and the height of the dot meets all international requirements. Smithers Pira transit trials have also confirmed the robustness of the Braille. The Marburg Medium typeface is used, which is recommended by relevant European and North American standards for pharmaceutical packaging. 17
Cartons and Leaflets Carton Manufacturing Using Lithographic, Screen and Digital print processes we have the facility to provide quality, flexibility and competitive pricing from small batches to large all with PS9000 accreditation. Our carton printing and finishing equipment is fully focused on achieving the optimum make-ready times whilst maintaining the highest levels of quality. We produce a variety of different style cartons from conventional RTE and aeroplane tuck through to crash lock base cartons, clinical trial wallets and complex integral insert packs.
No handling or transport charges are applied to our pricing when CMS carry out the packing operation. For short runs why not consider using our digital printing service?
Carton Production includes: > UV lithographic printing > UV screen printing > Clinical trial blister wallets (including heat seal) > Digital printing > Pharmacode scanning > Security systems
Chester Medical Solutions hold a PS9000 Accreditation for the production of conventional and digitally printed cartons and leaflets. 18
> Segregated production areas > Accurate reconciliation & vendor certification > PS9000 Accreditation
Leaflet Manufacturing Our leaflet printing machinery focusses on reduced make ready times and high output speeds whilst maintaining the highest levels of quality. Finishing capabilities include guillotining and folding machinery which can cater for the most complex of styles.
Leaflet Production includes: > Sheet fed lithographic printing
Die Cutting Our new Bobst Novacut 106E installation gives improved die cutting accuracy and tolerances on our more demanding product lines such as blister cards.
> Printing 40, 45, 50, 60 & 80gsm uncoated opaque paper > Supplied flat in brick style > Parallel folded or cross-folded and supplied in cassette trays
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Research, Development and Manufacturing Our sister company Quay Pharmaceuticals Limited, provides a comprehensive outsourcing service for formulation and analytical development with subsequent clinical trials manufacturing for pharmaceutical and biotechnology companies worldwide. Quay Pharma holds a Manufacturing Authorisation from the MHRA for the manufacture and testing of investigational medicinal products (IMP’s), as specified by the EU Clinical Trials Directive (2001/20/EC) and also a ‘Specials’ Licence. They are also FDA Approved. Quay Pharma has built a reputation for specialising in the formulation of API’s that exhibit poor solubility and bio-availability and those which require modified or controlled release. This has resulted in many Quay Pharma clients successfully licensing products on to large, global pharmaceutical companies. 20
From MHRA licensed and FDA approved facilities the company provides: > Drug characterisation and pre-formulation > Bio-availability enhancement > Formulation development > Analytical services > Manufacture of investigational medicinal products > Primary and secondary packaging of clinical trials > Clinical trial supply and distribution > Commercial manufacturing for low volume products > QC and QP Services
28 Parkway, Deeside Ind Park, Flintshire CH5 2NS Tel: +44 (0) 1244 837010 Web: www.quaypharma.com 21
AdditiveManufacturing Manufacturing Additive Consultancy Consultancy Our sister company, Addition Design additive manufacturing andprint 3D print Our sister company, Addition Design offersoffers additive manufacturing and 3D consultancy services. consultancy services.
Addition Design guides customers the additive manufacturing Addition Design guides customers into into the additive manufacturing world to unlock maximum benefit revolutionary world to unlock maximum benefit fromfrom this this revolutionary newnew technology. technology. Advantages ofPrinting 3D Printing (Additive Manufacturing): Advantages of 3D (Additive Manufacturing): Create products for higher prices Create products thatthat sell sell for higher prices Increase profit & reduce manufacturing Increase profit & reduce manufacturing costcost Drastically reduce lead times Drastically reduce lead times Reduce reliance on supply chain Reduce reliance on supply chain Drastically reduce manufacturing waste Drastically reduce manufacturing waste 3D print new materials as well as metals, ceramics plastics 3D print new materials as well as metals, ceramics and and plastics 22
ADD IITOI O ADDIT NN
AR D E SDIEGSNI G&N R&E SREEAS RE C HC H
Advanced by design. Advanced by design.
Addition Design is led by: TOM FRIPP
Additive Manufacturing/3D Print Site: Tom Fripp Design Director (0) 1142693869 Email: tfripp@addition.design Addition Design Limited Unit 1A Building 3 Advanced Manufacturing Park Technology Centre Brunel Way Sheffield S60 5WG (0) 1142693869 www.addition.design
4 Steps to unlocking the benefits of Additive Manufacturing: Additive Manufacturing Consultancy
3D Print Training
We identify real opportunities.
Find out about 3D printing.
Design for Additive Manufacturing
Sub-Contract Manufacture
Advanced design services, unique to us.
Supply of Additive Manufactured parts.
An internationally recognised, multi award-winning additive manufacturing design expert who has developed concepts that take advantage of additive manufacturing to create profitable products and devices for SMEs, multinationals and blue-chip companies in numerous market sectors including; consumer goods, health and safety equipment, automotive, sports, medical devices and specialist industrial equipment.
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Contacts: Tammy Williams
Location Map
Ian Robinson
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Director of Business Development Tel: +44 (0) 7854 836138 E-mail: irobinson@chestermedical.com
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Sales Director Tel: +44 (0) 7764 232340 E-mail: twilliams@chestermedical.com
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BROMBOROUGH
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FROM NORTH WALES CHESTER & M53
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Chester Medical Solutions - BROMBOROUGH Site
Chester Medical England Solutions - BROMBOROUGH Site Chester Medical Solutions is a trading style of ADS Graphics Ltd. Registration No. 2233870
Chester Medical Solutions - BROMBOROUGH Site
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UNIT 48
M56
A540
DEESIDE
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Queensferry A494
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NORTH WALES FROM N. WALES FLINT & BUCKLEY
Ellesmere Port
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Unit 48 | First Avenue | Deeside Industrial Park | Deeside | Flintshire | CH5 2NU Tel: +44 (0) 1244 281 880 | Fax: +44 (0) 1244 281 882 | www.chestermedical.com PS 9000
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ADS Graphics & Chester Medical Solutions - DEESIDE Site DEESIDE INDUSTRIAL PARK
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Sales Manager Sales Manager Tel: +44 (0) 7474 707371 Tel: +44 (0) 7814 202162 Accreditations Logo Guide E-mail: kwilkinson@chestermedical.com ADS Graphics & Chester Medical Solutions - DEESIDE Site E-mail: mdavies@chestermedical.com
Hawarden A55
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Chester
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