INNOVATIVE PROGRAMS + COMPASSIONATE CARE + NATIONALLY-RECOGNIZED RESEARCH Summer 2014
A Publication of the University of South Alabama Mitchell Cancer Institute
Through the right combination of research and treatment, we provide the whole picture of
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AROUND THE INSTITUTE
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1660 Springhill Avenue • Mobile, Alabama 36604
Interim Director
From the Director
Ronald D. Franks, M.D.
Administration
Kenneth J. Bloch Mary Lou Bowers Laurie Owen, Ph.D. Margaret Sullivan
MCI Physicians
Thomas W. Butler, M.D. Daniel G. Cameron, M.D. David R. Clarkson, M.D. Michael A. Finan, M.D., F.A.C.S. Carole Wiseman Norden, M.D. Roger Ove, M.D., Ph.D. Rodney P. Roconni, M.D. John R. Russell, M.D. Suzanne Russo, M.D. Jennifer Scalici, M.D. William R. Taylor, M.D. Mary Vu, M.D.
Dear Friends,
MCI Member Physicians
Warren R. Amos, M.D. Rasha Beg, M.D. Gerhard A. W. Boehm, M.D., F.A.C.S. Russell E. Brown, M.D. Ming-Chen Chang, M.D. Michael E. Damrich, M.D., F.A.C.S. Larkin J. Daniels, M.D. Jack DiPalma, M.D. D. Lynn Dyess, M.D. Matthew M. Eves, M.D. Edward R. Flotte, M.D. Lee Grimm Jr., M.D. Curtis N. Harris, M.D. S. Bennett Hooks III, M.D. Harvey Hsiang, M.D., Ph.D. Henry Hsiang, M.D. Hamayun Imran, M.D., M.Sc. Dimitris K. Kyriazis, M.D., F.A.C.C., F.A.C.S. Robert L. Long, M.D., F.A.C.S. Carl Maltese, M.D., F.A.C.S. David E. Mann Jr., M.D. Anthony Martino, M.D. Ronald B. O’Gorman, M.D., Ph.D., F.A.C.S. Allen Perkins, M.D. William Richards, M.D. Paul Rider, M.D. Hafeez Siddiqui, M.D. Brad A. Steffler, M.D. James Stevens, M.D., F.A.R.C.O. Marcus Tan, MBBS (Hons) Lee W. Thompson, M.D., F.A.C.S. Zhiqing Xing, M.D.
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he University of South Alabama Mitchell Cancer Institute continues to grow and thrive. Our clinical enterprise is robust. We are developing multidisciplinary teams in the areas of breast cancer, gynecologic cancer, gastrointestinal cancers and other cancers. By bringing entire teams of disease-focused specialists together, we provide precision medicine to our patients.
In January of this year, Dr. Mary Vu joined our medical oncology service and sees patients at both the main MCI campus and in our Fairhope office. Ronald D. Franks, M.D. Completing her medical oncology fellowship at Vanderbilt University, this energetic and talented physician focuses on lung cancer, melanoma, and head and neck cancers. Our clinical trials portfolio continues to expand and we have introduced a comprehensive patient navigation program to enhance our patient-centered approach to care. Over 600 patients are under active navigation and this number is growing….you can read more about our navigators in this second edition of our magazine. Our patient navigation program is an example of successful collaborations underway with the University of Alabama at Birmingham (UAB) Comprehensive Cancer Center. Other collaborations in cancer control and prevention, pancreatic cancer research, and clinical trials are forging ahead. We firmly believe these collaborations will enhance cancer health outcomes for the state, reduce health disparities and foster economic development that benefits us all.
C H A R I TA B L E F O U N D AT I O N
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Never before has research in cancer been as critical as it is now and never before has funding been so difficult to obtain. Even with national funding constraints for research, MCI scientists continue to obtain extramural funding, with three researchers receiving NCI grants in May alone. In this second edition of “Minds Conquering Cancer” you will read about the exciting research underway at MCI as well as new clinical faculty, great outreach and community involvement and inspirational stories of hope and courage.
Through the right combination of resources, we provide the total picture of patient care.
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We continue to build upon these accomplishments to win the war against cancer-one battle at a time. Thank you for your support of the MCI. Together, we can make a difference to improve the cancer burden in our region and beyond. Sincerely,
Ronald D. Franks, M.D.
Vice President for Health Sciences, USA Interim Director, USA Mitchell Cancer Institute
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AROUND THE INSTITUTE MCI represents a total investment of over $135 million, including $85 million in construction and equipment.
At A Glance
USA Mitchell Cancer Institute In the fight against cancer, nothing should be left out. Everything matters. The leading-edge research. The state-of-the-art clinical services. The commitment to new screening tools, new treatments and new prevention techniques. It is the combined efforts of all the minds behind these efforts – scientists, physician specialists, primary physicians, and, yes, patients—that make the difference. This is why USA Mitchell Cancer Institute (MCI) focuses on the entire package of care. With a strategic goal of becoming a National Cancer Institute designated Comprehensive Cancer Center, MCI’s researchers and clinicians stand on the front lines in the battle against cancer. MCI takes pride in the accomplishments of our physicians, researchers and patients, and looks toward a progressive future
MCI represents the largest single research endeavor in the history of the University of South Alabama, with a total investment of over $135 million, including $85 million in construction and equipment. MCI faculty and staff total approximately 300 employees, with continuous recruitment of clinical faculty and funded researchers underway. Oncology teams at MCI include: Medical Oncology (six medical oncologists), Radiation Oncology (three radiation oncologists), and Gynecologic Surgical Oncology (three gynecologic oncologists). Together with three Pediatric Oncologists within the USA Department of Pediatrics and five Surgical Oncologists within the USA Department of Surgery and others in the community, care is provided in a multidisciplinary team approach. In addition, MCI has over 32 associate, affiliate and member physicians within the service area. The 150-mile radius service area of MCI consists of over 4.1 million persons.
of innovation that advances cancer treatment in our region and beyond. MCI is the only academicbased cancer research and treatment facility in the southern part of the state of Alabama and the entire upper Gulf Coast region.
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MCI clinical areas include a state-of-the-art radiation oncology department with the full continuum of radiation oncology modalities including: CyberKnife Stereotactic Radiosurgery System; TomoTherapy System; and, three Varian Linear Accelerators. MCI is one of only five outpatient centers in the nation to offer the CyberKnife Robotic Radiosurgery System 4 and TomoTherapy System under one roof.
A Publication of University of South Alabama Mitchell Cancer Institute
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In the last 18 months, over 9,400 cancer patients were treated at MCI, generating over 60,000 patient visits. The MCI Medical and Radiation Oncology Divisions also operate clinics located in Fairhope, providing easy access to patients in Baldwin County. The USA Health System includes the USA Medical Center and USA Children’s & Women’s Hospital, both academic tertiary specialty hospitals.
The MCI cancer research enterprise includes 11 Principal Investigators/Individual Laboratory Heads, 14 postdoctoral trainees, eight graduate student trainees and over 27 specialized laboratory support staff. In May 2014 alone, three Principal Investigators were awarded NIH grants.
The MCI research infrastructure consists of established core laboratory facilities in the areas of flow cytometry, advanced imaging, genomics, proteomics, pathology, tissue biobank and drug discovery. These phenomenal core laboratories provide the infrastructure to enable MCI researchers and other USA researchers to be competitive for peer-reviewed grants, as evidenced in our rapidly increasing grant portfolio.
Cumulative extramural grant funding exceeds $17 million. On average, each Principal Investigator has $1.8 million in grant funding. Since 2007, MCI has filed 42 patents on inventions related to cancer diagnostics and/or therapy. MCI has two technology platforms licensed to two companies, Swift Biotechnology (six patents) and Braintree Labs (two patents).
Give the
Gift of Hope USA Mitchell Cancer Institute brings hope to thousands along the Gulf Coast by making a significant difference in the prevention, diagnosis and treatment of cancer. But hope doesn’t just come from within our building. It comes from our entire community. People just like you. When you make a gift to MCI, you become an important stakeholder in our mission and help provide hope to those suffering from cancer. One hundred percent of your donation supports cancer research or patient services at MCI. For more information, contact Kelly McCarron, Director of Development, MCI, at 251-445-8423 or Kmccarron@southalabama.edu.
FREE
Subscription Minds Conquering Cancer
A Publication of University of South Alabama Mitchell Cancer Institute
In 2013, MCI and the University of Alabama at Birmingham (UAB) Comprehensive Cancer Center entered into a declaration of intent to establish a Cancer Center Consortium. Research collaborations are underway that will ultimately improve cancer outcomes and reduce cancer health disparities for the citizens of Alabama.
For a free subscription to: MCI’s Minds Conquering Cancer, please call Kathy Eslava at 251-445-9819 or send an email with your name and address and request for a free subscription to keslava@health.southalabama.edu.
Minds Conquering Cancer | Summer 2014
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summer
2014 ISSUE 1 • VOLUME 2
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Mitchell Fund Supports Interdisciplinary Research
Promising Pancreatic Cancer Research
FEATURES
27 Survivor Story James Bryant
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Palliative Care Enables Greater Quality of Life
Table of Contents
AROUND THE INSTITUTE
3 4 8 10 12 14 15 42
Letter from the Director At a Glance Delchamps Award Mayer Mitchell Award New USA President: Dr. Tony Waldrop New Physician: Dr. Mary Vu Tribute to the late Dr. Eddie Reed New Chamber board members Calendar of Events
RESEARCH 20 21
Dr. Ajay Singh Receives NIH Grant MCI Researchers Receive NCI Awards
TREATMENT 25
Coping with Cancer
OUTREACH 32 34 35 35 36
Chemoflage Event A Message of Prevention Oncology Outlook Survivor’s Day Love Hats Think Pink Tea 2013
DEVELOPMENT 37 38 39 40 41
PNC Grant Provides Patient Assistance Donor Profile: E.E. Delaney Foundation Rent Pink Benefits MCI Celebrate Hope 2013 Point Clear Charities
A Publication of University of South Alabama Mitchell Cancer Institute
EDITOR Meredith Portman
WRITERS Sissy Louise Moore Meredith Portman Greta Sharp
PHOTOGRAPHERS John Adams Glenn Andrews Keith Necaise Bill Starling Jeff Tesney
CREATIVE DIRECTORS Laura Burton Andy Zak -
PRINTING University of South Alabama Publication Services
Produced in cooperation with the University of South Alabama Department of Public Relations
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AROUND THE INSTITUTE
MITCHELLS RECEIVE CHAMBER’S HIGHEST HONOR FOR LEADERSHIP
Abe Mitchell and Arlene Mitchell received the Alfred Delchamps Award in recognition of their philanthropy from the Mobile Area Chamber of Commerce at their 177th annual meeting on Feb. 4, in the Mobile Civic Center Theater. The Delchamps Award is only given when a champion of Mobile’s visions and principles is nominated, not on an annual basis. The Mitchell family has a long history of generosity to the Mobile community, and especially to the University of South Alabama. The university has received multiple gifts and guidance from the family. The late Mayer Mitchell served on the USA board of trustees for more than 32 years, with his wife, Arlene, succeeding him in 2007. Mayer, Arlene, and his brother, Abe, were instrumental in creating USA’s Mitchell Cancer Institute through their support, influence and a $22 million gift. The facility was the fulfillment of a personal pledge made by Mayer Mitchell, who battled cancer several times in his life, when he was diagnosed for the first time at age 36. As he got on a plane bound for New York for treatment, he said to his wife, “If the good Lord lets me live, one day there’s going to be a firstclass cancer center in Mobile for people who can’t afford to go away and aren’t able to leave their families.” He lived to see MCI under construction.
“If the good Lord lets me live, one day there’s going to be a first-class cancer center in Mobile for people who can’t afford to go away and aren’t able to leave their families.” – Mayer Mitchell 8
Minds Conquering Cancer | Summer 2014
Last May, Abe Mitchell pledged a $50 million matching gift, announced as part of the university’s 50th anniversary and as a tribute to late President Emeritus Gordon Moulton. The gift will go toward scholarships and to support the Mitchell College of Business. Combined with the $43 million previously given by the Mitchells, the family’s total amount of giving to the University of South Alabama exceeds $93 million. In addition to USA, the Mitchell family has given generously to arts organizations and other schools in the area including the Gulf Coast Exploreum, Mobile Symphony, Mobile Public Library, Spring Hill College, the University of Mobile and Bishop State Community College. We are humbled by their generosity and couldn’t be more appreciative.
left to right: Acting USA President Dr. John Smith, Arlene Mitchell, Dr. Richard Honkanen, Dr. Laurie Owen, and Dr. Ronald Franks
USA RESEARCHER RECEIVES MAYER MITCHELL AWARD Dr. Richard Honkanen was the recipient of the fourth Mayer Mitchell Award for Excellence in Cancer Research last fall. The prestigious award was presented by Mrs. Arlene Mitchell, at Mitchell Cancer Institute. Dr. Honkanen, a professor in the department of Biochemistry in the USA College of Medicine, was recognized for his work over the past 19 years in reversible phosphorylation, focusing on the PPP-family of protein phosphatases. In particular, his research centers on developing novel methods to inhibit a protein phosphatase that is overexpressed in breast cancer. When this phosphatase is overexpressed in mouse models of tumor progression, the tumors grow very fast. Inhibitors of the phosphatase essentially turn it off, which prevents tumor progression. Through this research, he hopes to develop novel phosphatase inhibitors that will hopefully lead to the development of a new class of chemotherapeutic agents.
A holder of nine U.S. and international patents, Dr. Honkanen’s research has resulted in more than 80 peerreviewed publications, published in the top journals in his field and numerous international and national research presentations. Since his first appointment at USA, he has been continuously supported by both the National Institutes of Health and by industrial grants and has received nearly $7 million in support of his research. Dr. Honkanen is also a teacher and research mentor who has served on the Ph.D. advisory committee of more than 30 Ph.D. students. Arlene Mitchell, who is a trustee of the University of South Alabama, established the endowment in July 2009 in memory of her late husband, who was a driving force in establishing the Mitchell Cancer Institute. The Mayer Mitchell Award provides an unrestricted award to a promising scholar/scientist each year.
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AROUND THE INSTITUTE
Dr. Tony G.
WALDROP President of the University of South Alabama
I
n April, Dr. Tony G. Waldrop became the third president of the University of South Alabama in its 51-year history.
An accomplished researcher, teacher and administrator in higher education for more than 30 years, Waldrop was selected from an initial field of more than 130 candidates from across the country. His research and medical background were a key factor in his selection as he takes over a university that has not only become a comprehensive, global institute of learning, but also a regional player in providing first-class medical training and leading-edge research. Through USA’s College of Medicine, Physicians Group, Medical Center, Children’s & Women’s Hospital and the Mitchell Cancer Institute, students receive a top-notch medical education and the community benefits from advanced medical treatments. Since 2010, Waldrop served as provost and executive vice president at the University of Central Florida (UCF). As its second-highest ranking officer, he provided academic leadership for the university’s 12 colleges, multiple campuses and research centers and institutes. His previous positions included vice chancellor for research and economic development at the University of North Carolina (UNC) and vice chancellor for research at the University of Illinois. Waldrop has a bachelor’s degree in political science, a master’s in physical education and a Ph.D. in physiology,
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all from UNC. He enrolled in 1970 at UNC as a John Motley Morehead Scholar – one of the oldest, most prestigious merit scholarship programs in the United States. A standout athlete, he won two NCAA championships as a mile runner on the track and field team and, in 1974, set a world record for the indoor mile at three minutes and 55 seconds. After leaving North Carolina, he continued his training at the University of Texas Southwestern Medical Center in Dallas in 1982 as a Research Fellow in the Cardiopulmonary Division, receiving a National Institutes of Health postdoctoral fellowship at the Moss Heart Center. In 1986, he joined the faculty in the department of physiology and biophysics at the University of Illinois, earning the school’s Arnold O. Beckman Research Award, and was recognized as a University Scholar and an American Heart Association Established Investigator. Waldrop returned to his alma mater in 2001 as UNC’s vice chancellor for research and economic development and as a professor in the department of cell and molecular physiology. Nine years later, he was tapped for the position at UCF. Waldrop is a native of Columbus, North Carolina, and is married to Dr. Julee Waldrop, who holds a doctor of nursing practice degree from Duke University. He succeeds the late Gordon Moulton, who retired July 1, 2013, after 15 years as president. Dr. John W. Smith served as acting president.
“One of the unique aspects of the University of South Alabama is its remarkable Health System, which includes USA’s Mitchell Cancer Institute,” says Dr. Waldrop. “As someone who has been touched by cancer in my own family, I appreciate the incredible research and treatment mission of MCI and the impact it has and will have on cancer patients.” Minds Conquering Cancer | Summer 2014
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Dr. Mary Vu combines love for science, passion for patients. 12
Minds Conquering Cancer | Summer 2014
AROUND THE INSTITUTE
Dr. Mary
VU
New Physician
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r. Mary Vu was recently appointed as an assistant professor of interdisciplinary clinical oncology. “As more advances are being made in the field of oncology, it is an exciting time to be involved with cancer care here at the University of South Alabama Mitchell Cancer Institute,” she states. “The word ‘cancer’ is very frightening not only to patients but also to their families and loved ones,” explains Dr. Vu. “The patients I encounter inspire me with their resiliency in the face of uncertainty and their courage in the fight for their lives.” In the field of oncology, she combines her love for science and passion to bring hope and healing to those afflicted with cancers. Being involved with patients is an important part of medicine for Dr. Vu, who finds joy in caring for each patient because each one is unique and memorable in his or her own right. “It is very important to me to be able to establish trust and be a good listener to my patients because it is a partnership of care,” she says. “What they have to say is very important in determining their treatment decisions.” Dr. Vu grew up in Bayou la Batre, and has returned to join MCI.
Prior to this position, Dr. Vu completed a hematology/oncology fellowship at Vanderbilt University. Her fellowship research investigated the roles of combination therapy, specifically PI3K inhibitor and mTOR inhibitor, in basal-like breast cancer cells. While at Vanderbilt, she served as a guest lecturer to second-year medical students, speaking on “Endocrine Therapies in Breast Cancer.” She also conducted a teaching series for residents on hematology and oncology topics. Dr. Vu is a member of the American Society of Clinical Oncology, the American Society of Hematology and the American College of Physicians. She attended the University of Alabama at Birmingham School of Medicine, then completed her residency in internal medicine at the University of Alabama at Birmingham. She was also a post-baccalaureate cancer research fellow, investigating the role of transforming growth factor-beta in breast cancer progression. She sees patients at the Mitchell Cancer Institute in Mobile and Fairhope.
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AROUND THE INSTITUTE
MCI mourns loss of a
Renowned Colleague
2008-2012, he served in many roles, including clinical director, associate director for cancer prevention and control, and Abraham Mitchell distinguished investigator. He was a beloved figure who made an impact on everyone who knew him. Dr. Bruce Chabner, chair of MCI’s Executive Advisory Board and professor of medicine at Harvard Medical School has known Dr. Reed since he worked in his lab at the National Cancer Institute in 1972. “Eddie Reed has had a remarkable career,” he states. “He has been an inspiration and a valued collaborator, leader, and friend to countless cancer researchers and clinicians throughout the country. We acknowledge his passing with great sadness and with appreciation for his many contributions and his friendship.” “We are deeply saddened to lose such a dear friend and colleague,” said MCI’s Associate Director for Clinical Research Dr. Rodney Rocconi, “Eddie’s countless contributions to cancer literature positively affected many patients’ lives. He was quite simply a champion in the field of cancer.”
Dr. Eddie Reed, a champion of cancer care for the underserved, passed away on May 28 at age 60 from the disease he had devoted his life and career to fighting. He was serving as the clinical director of the National Institute on Minority Health and Health Disparities of the National Institutes of Health (NIH) in Bethesda, Md., at the time of his death. A world-renowned cancer expert, he was internationally known in the cancer research field for his two interests – cancer drug development and cancer care for underserved populations. At Mitchell Cancer Institute, Dr. Reed was part of the family. From
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Dr. Reed split his efforts between his clinical practice and research endeavors at MCI. His clinical focus was on ovarian and metastatic prostate cancer, while his research concentrated on molecular pharmacology and clinical development of novel platinum compounds. Throughout his career, he also collaborated on many cancer prevention, screening and control programs. For the Alabama Department of Public Health, Dr. Reed headed up a prostate screening initiative and a colorectal initiative aimed at reducing health disparities. Even after he left MCI for his NIH position in 2012, he remained on the MCI staff as an adjunct distinguished professor. Dr. Reed’s clinical research focused on DNA damage and repair in cancer cells in response to pharmacological anticancer agents. He conducted more than four dozen Phase I or Phase II
clinical trials of various agents during his career and was internationally renowned for his pioneering work in the clinical development of Taxol for the treatment of ovarian cancer. Dr. Reed also served as a member of the board of directors of the American Association for Cancer Research. Prior to his appointment at USA, Dr. Reed worked at the Centers for Disease Control in Atlanta as director of the division of cancer prevention and control. “Eddie’s piercing intellect, quiet wisdom, impeccable character, and passion to provide stellar patient cancer care will be sorely missed,” says Dr. Laurie Owen, associate director of basic and translational sciences at MCI. “His contributions to the field of drug development and DNA damage and repair are extraordinary, but it is his unfailing commitment to confront and address health disparities that will be his enduring legacy.” Dr. Reed’s illustrious career was a remarkable rise from humble beginnings. One of 17 children born in Arkansas to a poor family of sharecroppers, among the last in America, Dr. Reed went on to earn his medical degree from Yale University, and completed his internship and residency at Stanford University. He is survived by his wife, Dr. Meenakshi Reed.
A Generous Spirit Through his pioneering work and generosity, Dr. Eddie Reed left a legacy that will positively impact future generations of cancer patients. To honor his work at the Institute, MCI is establishing The Eddie Reed Memorial Lectureship Endowment. Anyone wishing to make a gift to his endowment should contact the office of development at 251-460-7032 or mail it to: Office of MCI Development, 300 Alumni Circle, Mobile, AL 36688.
Familiar Faces
2014 Chamber Board
S
wift Biotechnology Chief Executive Officer Michael Chambers has been named the chairman of the Mobile Area Chamber board of directors for 2014.
Michael Chambers Swift is developing several technologies in collaboration with a team from the Mitchell Cancer Institute, including screens for endometrial and ovarian cancer, two of the leading causes of death in women in the United States. Housed at MCI, Swift has received a $1.2 million grant from the National Institutes of Health and an international award for Best Global Research. “We are thrilled to have Michael serve as chair of the board this year,” said Bill Sisson, the Chamber’s president and chief executive officer. “The timing could not be better. His background and expertise have provided excellent vision and leadership as the Chamber works to enhance its programming in small business and entrepreneurial development.” Over the course of the coming year, the chamber plans to launch several initiatives to help small businesses adapt to a changing global market, which included a weeklong program in May. “The Chamber has received praise for large projects like Airbus, ThyssenKrupp and Austal. But all big businesses start small,” noted Chambers. “We want to be there for small business, too. We will launch a mentorship program shortly, pairing entrepreneurs with specialists in their fields. We are also planning a general entrepreneurship training program. I am particularly interested in additional training with a biotech focus to leverage our strength in that area.” A lifelong entrepreneur, Chambers knows the territory well. In addition to Swift, he actively invests in early-stage,
Swift Biotechnology Chief Executive Officer
“The Chamber has received praise for large projects like Airbus, ThyssenKrupp and Austal. But all big businesses start small,” noted Chambers. “We want to be there for small business, too.” high-growth companies and serves on several boards of directors, including ProUroCare, a publicly traded company based in Minneapolis, Minnesota and InQ Biosystems, based in Huntsville, Alabama. He also serves as chairman of the Gulf Coast Angel Network. Previously, Chambers helped establish InnoRx Pharmaceuticals, a company specializing in developing drugs and drug delivery systems for ocular disease, in 1999. He served as president and CEO of InnoRx until negotiating its sale and merger into SurModics in January of 2005. Active in the community, he serves or has served on various boards of directors, including Rotary, the Rotary Children’s Foundation, the YMCA, Goodwill-Easter Seals, Prichard Preparatory School and the Presbyterian Home for Children. Chambers is also “of counsel” for the law firm of Cabaniss Johnston Gardner Dumas & O’Neal. Minds Conquering Cancer | Summer 2014
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r. Laurie Owen joined the Mitchell Cancer Institute in October 2008. In her current role as associate director, she is responsible for overseeing the research program, managing research infrastructure and intellectual capital of the research enterprise, identifying novel technologies and basic science discoveries for targeted pre-clinical development, and building an academic culture that drives useinspired cancer research.
Laurie B. Owen A native of Mobile and a graduate of the University of South Alabama, Dr. Owen earned her Ph.D. in Microbiology and Immunology at the University of Oklahoma Health Science Center and completed her postdoctoral work at The University of Texas M.D. Anderson Cancer Center (MDACC). Dr. Owen holds four patents related to the development of novel cancer therapeutics forming the basis for a spinout biotechnology company in 1993 at MDACC that became a publicly traded company (Introgen Therapeutics). She became founding scientific director of a second biotechnology start-up in 2003 (BioLegend).
Associate Director of Basic and Translational Sciences at MCI
“I am excited to represent the Mitchell Cancer Institute on the Board of Directors for the Mobile Area Chamber of Commerce. Service on the Board increases our visibility in the business community and allows us to showcase our culture of innovation, highlight our ongoing translational research, and leverage our emerging technologies to enhance economic development in our region.�
2014 CHAM In addition to her role on the Chamber Board, she currently serves as board member for the Melton Center for Innovation and Entrepreneurship, BioAlabama, and the American Cancer Society Mid-South Division.
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s vice president for research and economic development at USA, Chronister oversees research growth across the institution, including interdisciplinary research efforts, resource development and orchestration of all phases of research administration. She serves as the principal spokesperson for research administration programs and services, engages in strategic planning for university-wide research initiatives and ensures effective and efficient pre- and post-award processes to maintain and advance research compliance.
Vice President for Research and Economic Development University of South Alabama
Lynne Chronister
“I am honored to be a part of the board as we realize the vision for 2014.”
Lynne Chronister oversees the activities of Research Compliance, Sponsored Projects Administration, Research Development and the Center for Commercialization and Industry Collaboration. Chronister also supports the Mitchell Cancer Institute, the largest research endeavor in the university’s history and the first academic cancer research institute in the upper Gulf Coast region, representing a total investment of $135 million. Recently, Chronister successfully spearheaded the grant application submission and award on behalf of the Mobile Area Chamber of Commerce’s Partners for Growth consortium. Southwest Alabama is one of 12 communities to receive the designation of Manufacturing Community by the U.S. Department of Commerce. USA, under Chronister’s leadership, will coordinate a consortium competing for substantial federal money to enhance workforce development.
MBER BOARD “I am honored to be a part of the board as we realize the vision for 2014,” says Chronister. “The Mobile Area Chamber and USA are natural partners. The Chamber has long played a vital role in shaping Mobile’s economic and social ecosystems and USA has contributed by educating our work force, improving the health of Mobile’s residents and enhancing the region’s research and technology base.”
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Mitchell Fund Supports
Innovative
Interdisciplinary
Research The projects and recipients are: Six projects from University of South Alabama (USA) scientists and researchers were recently chosen to receive more than $300,000 in awards from the Abraham A. Mitchell Cancer Research Fund. The peer-reviewed winners ranged from studies that pursue new antitumor drugs to a sunscreen that repairs damaged DNA. The goal of the fund is to support the growth of interdisciplinary cancerrelated or cancer-relevant research. Growth of this research throughout USA will promote increased collaboration with Mitchell Cancer Institute and accelerate MCI’s competitiveness to achieve a comprehensive cancer center designation by the National Cancer Institute. “Through the generosity of Mr. Abe Mitchell, we now have resources to support initial experiments to help discover the root causes of cancer, and to develop better treatments to cure this deadly disease,” said Dr. Ronald D. Franks, interim director of the Mitchell Cancer Institute.
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Silver Nanoparticles for Skin Cancer Chemoprevention Investigators: Dr. Srinivas Palanki, chair and professor of chemical and biomolecular engineering; Dr. Seema Singh, assistant professor of oncologic sciences at MCI Traditional sunscreen lotions simply block or reduce the amount of harmful Ultraviolet B radiation the skin absorbs. The team hopes to develop a sunscreen with an added component that could actually repair a damaged cell’s DNA.
Blockage of Melanoma Metastasis to Lymph Nodes by Focal Adhesion Kinase Inhibition Investigator: Dr. Steve Lim, assistant professor of biochemistry and molecular biology Malignant melanoma, a skin cancer, typically metastasizes to the lymph nodes as a primary lesion before secondary metastasis occurs. Lim is testing his hypothesis that reducing levels of a specific protein called VCAM-1 through a pharmacological FAK inhibitor could keep melanoma from metastasizing to the nodes.
The awards mark the first installment of grants from the fund. Each award is for one year and recipients may be considered for an additional year of funding depending on a project’s progress. A native Mobilian, Abraham Mitchell has been a longtime supporter of the University and the Mitchell Cancer Institute. The Mitchell family, which includes Arlene Mitchell and her late husband, Mayer, was instrumental in the formation of MCI and together have committed more than $93 million to the University.
Evaluation of MindfulnessBased Stress Reduction for MCI Patients Investigator: Dr. Elise Labbe’Coldsmith, professor of psychology This pilot study will explore the effectiveness of mindfulness–based stress reduction in improving psychosocial and immune system functioning in patients undergoing chemotherapy regimens.
Real-Time Hyperspectral Imaging for Identification of Colon Cancer
Development of Transgenic Rat Models Expressing RealTime CAMP Sensors
Investigators: Dr. Silas Leavesley, assistant professor of chemical and biomolecular engineering; Dr. Thomas Rich, associate professor of pharmacology
Investigators: Dr. Silas Leavesley, assistant professor of chemical and biomolecular engineering; Dr. Thomas Rich, associate professor of pharmacology
The investigators seek to improve endoscopic imaging capabilities of the lower digestive tract using an approach called hyperspectral imaging – filtering light before it reaches the camera over a series of wavelengths. The result is a multidimensional image that could allow physicians to better detect cancerous cells and improve the ability to remove cancerous tissues.
USA researchers aim to further the knowledge of cell evolution by developing rat models that would allow scientists to study biochemistry in single cells in intact living tissues and animals. The end result would be the ability to see alterations in signaling pathways that lead to cancer and monitor the effectiveness of drugs designed to inhibit these pathways.
Design, Synthesis and Testing of Novel Anti-Cancer Analogs of Norcantharidin that Exhibit Increased Potency and Selectivity Towards Serin/ Threonine ProteinPhosphatase 5 Investigators: Dr. Andrzej Wierzbicki, dean of the College of Arts and Sciences and professor of chemistry; Dr. David Forbes, chair and professor of chemistry; Dr. Richard Honkanen, professor of biochemistry; Dr. Larry DeLucas, director of the Center for Biophysical Sciences and Engineering at the University of Alabama at Birmingham The focus of the project is to develop selective and potent inhibitors of a protein that is observed in high levels in an invasive ductal carcinoma form of breast cancer. The team discovered several compounds with promising inhibitory activity which will be used as a starting point for the design of antitumor drugs.
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RESEARCH
disease, fails to provide any significant survival benefit due to chemoresistance. Therefore, there is a critical need to develop a better understanding of the molecular pathways driving the aggressive and drug-resistant nature of this malignancy. This new information can be immensely helpful in the development of an effective, mechanism-based, refined therapeutic approach against this lethal cancer type.
Singh receives
$1.5 Million NIH Grant Dr. Ajay Singh, assistant professor of oncologic sciences at USA Mitchell Cancer Institute, was recently awarded $1,566,625 by the National Institutes of Health (NIH) to advance research in the fight against pancreatic cancer. The Research Project Grant (RO1) will be awarded over the course of five years. Pancreatic cancer is one of the most lethal malignancies and currently stands as the fourthleading cause of cancer-related deaths in the United States. According to an estimate by the American Cancer Society, the one- and five-year relative survival rates for pancreatic cancer patients are only about 20 percent and six percent respectively. Despite significant improvement in survival rates for many other cancers, these numbers have not changed for pancreatic cancer over the past three decades. Therefore, pancreatic cancer remains an important clinical challenge for both the physicians and translational researchers. The poor outcome from pancreatic cancer is largely due to its late diagnosis and lack of effective therapy against the advanced disease. Chemotherapy, which is a preferred treatment option for the late-stage metastatic
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Pancreatic tumor mass is comprised of cancer as well as stromal cells. It is now being increasingly accepted that the interactions between the cancer and stromal cells play an important role in tumor progression, metastasis and chemoresistance. In this regard, Dr. Ajay Singh and his team of investigators at MCI have identified an inflammation-associated molecular pathway (chemokine signaling axis) to be of vital importance. This inflammatory pathway is activated in cancer cells by signals from stromal cells and makes them resistant to chemotherapy. Furthermore, elicitation of this pathway in cancer cells enhances the production of a stromal acting factor (hedgehog ligand) leading to establishment of bi-directional tumor-stromal crosstalk, which mutually promotes chemoresistance. As part of the NIH-funded project, Dr. Singh and his team will systematically investigate the significance of these signaling nodes (chemokine and hedgehog) in pancreatic cancer chemoresistance and provide mechanistic insights into the pancreatic cancer pathobiology. Furthermore, their research will yield preclinical evidence in support of a novel combination therapy against pancreatic cancer. In the longer term, the knowledge gained from the proposed investigations will open up new avenues for effective treatment of pancreatic cancer and thus enhance the life expectancy of patients diagnosed with this devastating and lethal malignancy. MCI and its team of researchers and physicians continue to work together to make great strides aimed at improving treatment and outcomes.
MCI RESEARCHERS RECEIVE
National Cancer Institute Awards
Three USA Mitchell Cancer Institute researchers were recently awarded funding from the National Cancer Institute (NCI) of the National Institutes of Health. Seema Singh, Ph.D., an assistant professor of oncologic sciences, received $151,125 to explore the chemopreventive abilities of silver nanoparticles to protect skin from ultraviolet radiation that causes skin cancer. Silver has been used for centuries to treat a variety of diseases and to heal skin wounds because of its antimicrobial and anti-inflammatory attributes. Dr. Singh and her team will also be researching economic and eco-safe methods to create synthetic silver nanoparticles that are comparable to actual silver. “We are devoted to developing safer and more effective ways to prevent and/or treat cancer,” says Dr. Singh. “The long-term goal is to impact public health and patient outcomes by enhancing disease-free survival and by improving quality of life.”
Assistant professor of oncologic sciences, Dr. Yaguang Xi, has been awarded $361,000 in funding over a two-year period to research the use of non-steroidal anti-inflammatory drugs
(NSAIDs) for prevention of tumor progression and metastasis in colorectal cancer. This is Dr. Xi’s second National Institutes of Health award to support his research programs; he is also an awardee of the American Cancer Society and American Association of Cancer Research. “Colorectal cancer continues to be the second leading cause of cancer-related deaths in the United States and in Alabama,” says Dr. Xi. “There is an unmet need to discover new strategies for the prevention and treatment of this deadly disease.”
MCI researcher Ajay Singh, Ph.D. received $1,570,000 over a five-year period to study the molecular causes of racial disparities in prostate cancer. This is his second NCI award. African American men are disproportionately affected with prostate cancer having nearly two-thirds higher incidence and mortality rates when compared to European American men. A team of investigators led by Dr. Singh has identified a protein (MYB) that is significantly overexpressed in prostate cancer in that population. His lab will focus on developing an improved understanding of the molecular mechanisms promoting tumor progression, metastasis and therapeutic resistance. “The knowledge that we are developing today will lay the foundation for novel and effective cancer treatment and prevention strategies of the future,” states Dr. Singh.
These three awards bring MCI’s current annual funding to 20 awards totaling more than $3,000,000 in this year alone. These awards demonstrate our growing recognition as a leading cancer research institute on a national and international level. Minds Conquering Cancer | Summer 2014
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Dr. Jana Rocker and Dr. Lewis Pannell are part of the team hoping to develop a commercial test for pancreatic cancer.
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P
ancreatic cancer is one of the deadliest forms of cancer. It is the fourth leading cause of cancer death with a dismal five-year survival rate of approximately six percent. It killed Steve Jobs, Randy Pausch, Patrick Swayze, and Sally Ride. In 2013, some 38,460 Americans succumbed to the disease, according to the National Cancer Institute. The discouraging survival rate, one of the lowest among cancers, is due to the lack of effective methods of early detection when it is most treatable. While pancreatic cancer develops extremely slowly, there are often no noticeable signs of the cancer until its later stages. The pancreas’ location in the body behind other organs also makes screening difficult.
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Exciting breakthroughs at the University of South Alabama’s Mitchell Cancer Institute could change the prognosis for patients. Our scientists and clinicians are expanding research that could lead to early detection and pre-diagnosis treatment of pancreatic cancer. Introduction of a simple, commercial test, where currently none exists, could save thousands of lives each year in the United States alone. USA Mitchell Cancer Institute researchers discovered a clean protein profile of the pancreas while doing research for colon cancer. This possible breakthrough could eventually lead to identification of a protein marker for pancreatic cancer. Of protein markers for cancer, PSA for prostate cancer is the best known. USA researchers believe the examination of these proteins could hold the key to early detection. This research evolved through Dr. Jana Rocker’s doctoral work in colon cancer. While the results look promising to date, according to Dr. Lewis Pannell, principal investigator, the research is still in its early stages and a commercial test is years away. The research began as a colon cancer study five years ago. When MCI scientists realized that they were observing a protein profile from the pancreas and not the colon, they teamed up with Dr. Lee Thompson, a surgical
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oncologist with Infirmary Health’s Cancer Surgery of Mobile, who performs many of the pancreatic surgeries in the area. He asked his patients to provide samples prior to surgery, and these became the basis of the discovery efforts. MCI is also actively collabarating with USA surgeons and gastroenterologist, including Dr. Marcus Tan and Dr. Jack DiPalma. Researchers now are expanding the sampling pool and recruiting volunteers. Specifically, Pannell said, he is looking for people with an immediate, blood relative who has or had been diagnosed with pancreatic cancer; people with pancreatitis or other non-cancer diagnoses of the gastrointestinal system; and people who have been diagnosed with pancreatic cancer but have not yet received treatment or had surgery. Pancreatic cancer can follow family lines, especially in cases where there is more than one pancreatic cancer diagnosis in a family. People who fit into one of these categories should call Pannell at 2451-445-9860 or email him at lpannell@health.southalabama.edu.
“We are hopeful that this research will lead to a commercial test for pancreatic cancer,” Pannell said. “If we are successful, the results could be profound.” A biotechnology company, Creatics, has acquired the two patents from USA connected to the research and has given some funding to the project.
Dr. Jana Rocker:
One-Armed Scientist in Pursuit of Deadly Cancers When it comes to cancer research, Dr. Jana Rocker is tenacious, according to mentor and supervisor Dr. Lewis Pannell. That’s because for Dr. Rocker cancer is personal, having lost her left arm to osteosarcoma at the age of 10. In 1982, Dr. Rocker developed this very aggressive bone tumor. She was referred to Dr. George Cierny, a specialist in limb salvage at the University of Texas Medical Branch in Galveston. Unfortunately, the tumor had enveloped the blood vessel and nerve, so Dr. Cierny had to amputate her arm, along with her clavicle and shoulder blade. She underwent chemotherapy and lost 50 pounds. While her treatment was traumatic, Dr. Rocker believes the aggressive surgery and treatment saved her life, as she has not had a recurrence since. Through the process, she also developed a fascination with science. But it took nearly 30 years for Rocker to reconnect with her early interest. After years of career disappointments and detours, a medical appointment at Mitchell Cancer Institute rekindled her passion for science. She applied to the Ph.D. program at the University of South Alabama, did a rotation in Dr. Pannell’s lab and never left. While Dr. Rocker’s doctoral work was in colon cancer, the methodology has formed the groundwork for extremely promising research in the detection of pancreatic cancer. This is especially meaningful for her as she recently discovered that her former doctor and mentor, Dr. Cierny, had passed away from pancreatic cancer last summer. Dr. Rocker is now a post-doctoral student in Dr. Pannell’s lab and plans to publish, apply for grants, and continue her promising research into the early detection of GI cancers.
THE
EMOTIONAL TOLL OF COPING WITH CANCER A
cancer diagnosis is a shock to the psyche, a sobering, life-changing event. Despite the frequent depiction in the media of the cancer patient who is cheerful and courageous throughout the ordeal, that’s not always the reality. “How would you expect a patient to feel, at least initially?” asks Dr. Elise Labbe’-Coldsmith, a University of South Alabama professor in the psychology department. “Scared, anxious, having feelings of loss of health and control, depressed, grieving.” The emotions related to cancer can vary from person to person and from one day to the next. But an innovative program from Dr. Labbe’-Coldsmith’s department can help Mitchell Cancer Institute patients who are having an ongoing struggle coping with the stresses of cancer. It started in 2011, when Dr. Labbe’-Coldsmith’s doctoral students began shadowing MCI oncologists as part of their instructional program. They soon recognized that there was a need for psychological services that might not be available for some
patients, particularly the uninsured or underinsured. Their role was expanded further when she received a research grant from the Abraham A. Mitchell Cancer Research Fund to gather data and document what types of issues students were encountering and whether interventions were successful. The students partner with Dr. Thomas Butler, an MCI oncologist and a proponent of supportive oncology, which he describes as “practicing medicine the way we used to do it, which means treating the patient as a whole, not just as a disease process.” “We’re treating cancer, but we want to make the patients feel as good as possible throughout this trajectory. We want to optimize their quality of life,” he says. When Dr. Butler’s patients come in for an office visit, they fill out the usual paperwork, but they also answer questions about how they are feeling and if
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a mindfulness approach that helps the patient be with and work through some of the pain or losses he or she will have. Meditation, yoga, and letting go of expectations or things that cause extra stress are also successful strategies. A strong spiritual faith is also important to many patients in their treatment and recovery. USA psychology graduate students left to right: Tyrannies Brazil, Stefanie Granato, Paige Naylor, Professor Elise Labbe’-Coldsmith, David Chavers, Kelley Drayer, Keri Johns, Katie Russ. Back row: James McAbee
they are interested in counseling. If a patient expresses an interest in services, a student would then be introduced. Dr. Butler emphasizes that not everyone wants or needs these services. Because the providers are students and the services they provide are part of their program, there is no charge. But Dr. Labbe’-Coldsmith stresses that these students are Ph.D.level, and counselors are usually only required to have a master’s degree to practice. Plus, they have been vetted, are supervised and meet once a week to review the cases. To Dr. Butler, the students provide an invaluable service. “The graduate students have been instrumental in keeping this project going,” he says. “They take their own time from school, and many have come in on nights or weekends when there’s a crisis.”
MEETING PATIENTS WHERE THEY ARE Dr. Butler often stresses the importance of “meeting patients
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where they are, not where you want them to be.” Does a patient understand his illness? How compliant is she to treatment? What’s happening at home? It’s hard to concentrate on your cancer treatment if you don’t know where your next meal is coming from. A person’s state of mind can affect how he or she responds to treatment. When patients feel that they are unable to manage or control changes caused by cancer or normal life activities, they are in distress. Distress has become increasingly recognized as a factor that can reduce the quality of life of cancer patients. Dr. Labbe’-Coldsmith advises her patients to both recognize and be with their feelings of fear and anxiety. “In the process, you come to realize those feelings are temporary,” she says. “They come and go. During treatment, you may have some periods of joy, even in your pain or loss.” Patients also learn strategies for coping in group and individual settings. This includes
“I see miracles every day,” says Dr. Butler. Another area of Dr. Labbe’Coldsmith’s program deals with cognitive issues resulting from treatments or specific types of cancer, like “chemo brain” or brain tumors. Through cognitive testing, they can figure out what deficits that person is experiencing and address them appropriately. In the end, Dr. Butler said, cancer care should be all about teamwork, an approach that includes social workers, psychologists and physical therapists. MCI has already introduced lay patient navigators who play a vital role in patient care by providing assistance throughout their treatment program. If there is a silver lining to cancer, Dr. Labbe’-Coldsmith observes that for many patients there is a renewed appreciation of life and purpose. “I think any time you have a life– changing event like cancer, you morph into a different person,” she says. “We call it posttraumatic growth in that some people experience a renewal, a reawakening of who they are and their ability to appreciate life in a way they never could before.”
L
f o e v o L y l i m a F ttle a B r e c n a C an in r e t e V s e ir p s In rts o Purple Hea tw s a h d n a r t is a survivo James Bryan m, this Army a tn ie V f o rs u rough two to ge. to prove it. Th at an early a e lif n o e v ti ed perspec veteran gain
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“At 19 years old in 1965, I came to terms with dying in Vietnam,” he says.
“It doesn’t scare me.” Still, a recent diagnosis of Stage 1 lung cancer was a setback. An unapologetic smoker of 50 years, he doesn’t blame cigarettes for the cancer—but he does plan to stop. “I have to, since my lung capacity has gotten so bad,” Bryant says with a chuckle. He admits he wasn’t laughing just a few months ago. He says there was a time when he felt so badly that he just wanted to “lie down in a corner and quit.” But the love of his family—his wife of nearly 50 years, DeLane, as well as two sons and two daughters, five grandchildren and four great-grandchildren (with one on the way)—has helped him keep going.
From Cold to Cancer Around Thanksgiving of last year, 68-year-old Bryant had what he thought was either a cold or the flu, which lasted about 10 days. He went to the doctor, who prescribed an antibiotic and sent him home. He felt better for a while, then relapsed. The third time he went to his doctor, a chest X-ray detected a mass on his right lung. The next morning, he had a CT scan in Brewton and was told that, in addition to the mass, he had three lesions in his lung. Mobile was the nearest city with a specialist, so the Bryants made the two-hour trip from their home in Castleberry, Alabama, for an appointment with vascular surgeon Dr. Ralph Pfeiffer the next morning. Dr. Pfeiffer admitted Bryant to Mobile Infirmary while they waited for his CT scan results to be released. At that point, Dr. Pfeiffer was more concerned about what he suspected might be aneurysms in Bryant’s neck and chest. Fortunately, they didn’t turn out to be
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life-threatening medical conditions, and the attention returned to his lung. “In a little over a week, I went from having a cold to being treated for lung cancer,” Bryant says. Bryant was referred to Dr. Mary Vu at Mitchell Cancer Institute, who specializes in the disease. She explained to the couple the good news, that his cancer was Stage 1, which meant it hadn’t spread beyond his lung. But it was inoperable, so chemo and radiation would be his only treatment options. Dr. Suzanne Russo came aboard as his radiation oncologist. “One of the things that stood out about the Bryants is their positive attitudes, motivation to be well and a sense of appreciation,” says Dr. Vu. “They are always ready to give you a warm smile that will make your day. I am honored to be a part of the team that helps him fight this cancer.” Bryant had once told his wife he would never have chemotherapy. Through his professional career years earlier as a construction manager in Houston, he had worked at M.D. Anderson and witnessed what chemotherapy was like. But he also felt there had been so many advances in recent years he’d give it a shot. “Still, I thought this isn’t going to be much fun,” he says. “But MCI’s chemo room is airy, full of recliners, TVs and computers. I’ve made several friends in there. The nurses and staff are amazing. In fact, everybody at MCI is like your kinfolks.”
Signs and Blessings Bryant was assigned to lay patient navigator Sissy Louise Moore, who is part of a Centers for Medicare and Medicaid Services program to provide assistance to patients throughout their treatment program. One concern the Bryants shared with Moore was that a street sign that marked the dirt road to their home had been stolen. DeLane was worried that if she were to call 911 for her husband, the ambulance couldn’t find them since their street doesn’t show up on a GPS. “Everybody told us it would take months to get that sign back up,” DeLane says. “We mentioned it to Sissy Louise, and in a week it was there.”
James Bryant’s lay navigator Sissy Louise Moore
Changing the world one patient at a time By Sissy Louise Moore
At Mitchell Cancer Institute, we like to think we are changing the way the world treats cancer. In addition to supporting cancer patients every day, MCI assigns each Medicare patient their own advocate, a lay navigator, to accompany them on their journey with cancer and resolve barriers to patient care. Although unable to change the diagnosis, a navigator can surely lighten the patient’s load and share hope and encouragement to help with the challeging days ahead. The reality is that with every diagnosis of cancer comes fear, anxiety, even confusion. Our patients are faced with crucial decisions to make, and they have an urgent need for information they can trust. Levels of distress are often identified in 85 percent of cancer patients.
Recently, they also got good news from Dr. Russo. When she found out about the Bryants’ upcoming 50th anniversary on July 3, she told them they would “make that one.” “You can’t believe what a blessing it was to hear that,” DeLane says. Another blessing came in the form of a phone call. Bryant, a diehard Auburn fan, received an unexpected call from Pat Dye. Naturally, at first Bryant thought someone was playing a joke, but he soon realized he was talking to the football legend. Wanting to cheer his Dad up during his treatment, Bryant’s oldest son had called Dye’s office and requested a phone call, even though his secretary didn’t give him much hope. She told him “he doesn’t do this kind of thing.” For now, the Bryants are staying in a travel trailer at an RV park in Mobile until his treatment ends. Once that’s over, he hopes to spend lots of time on his favorite hobby, bass fishing. For James Bryant, the future holds many more blessings and reasons to live, like a 50th anniversary and a fifth greatgrandchild.
As one of the associates of the (UAB Health System Cancer Community Network), I am proud to have a part in this navigator program because every day I see new ways in which it is helping to guide and empower our patients, their families and caregivers through the challenges that come with cancer treatment and recovery. Seeing this in action is what gets me up every morning and keeps me moving forward with determination and optimism. As part of a complex medical team, the navigator’s role is to assist the patient and/or family and caregiver with information to help them make informed decisions regarding their care, to provide emotional support, and assist them with problems that inevitably arise. A navigator can seem like an onlooker or a magician or juggler of sorts. Coordinating multiple resources, arranging transportation, producing information and support on the spot… it can seem a little supernatural at times! But always, a navigator is an advocate for the patient in whatever form that might take. My patient, James Bryant, was finding it more and more difficult to get up the steps leading into his home. Even though he lived in another town, it only took a couple of calls to find a qualified person to build him a ramp. Then his wife was concerned that someone had stolen their street sign and that if she called EMS they would not be able to find their street. This time it took only one call to the engineering department of Conecuh County to alleviate Mrs. Bryant’s anxiety! Stories like these; narratives of compassion and care and concern, where needs are met and problems are solved (or at least addressed) are all in a day’s work in the daily life of a lay navigator at Mitchell Cancer Institute. To help your loved one receive the responsive, informative, and compassionate services of their very own navigator, contact the Mitchell Cancer Institute to see if your loved one is eligible for this program. Minds Conquering Cancer | Summer 2014
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TREATMENT
Higher Quality of Life
GRANT ENABLES
FOR CANCER PATIENTS
A
t the Mitchell Cancer Institute (MCI), the only academic cancer institute along the central Gulf Coast, scientists, physicians, and advance practice nurses work together on cutting-edge medical treatment and research. Recently, MCI was invited to participate in an American Cancer Society grant with the University of Alabama at Birmingham, adding an important service in the treatment of women’s cancers—palliative care. The grant, which focuses on palliative care for chronic or terminally ill patients, is known as the ENABLE Project, standing for “Educate, Nurture, Advise Before Life Ends.” The ENABLE Project has been implemented in the care of patients with multiple chronic illnesses including cancer, heart failure and COPD. MCI will support the ENABLE Project through collaboration in support of ovarian cancer patients diagnosed at a late stage and their caregivers.
“It’s a supportive program for anyone who has been dealt the hardship of a terminal illness. Those ovarian cancer patients and their caregivers will benefit from the added support the program provides,” said MCI Gynecologic Oncology Nurse Practitioner Dr. Leigh Minchew, DNP, RN, WHNP-BC.
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Gynecologic oncology includes cancers specifically affecting the female reproductive organs: the uterus, ovaries, cervix, fallopian tubes, vulva and vagina. The most deadly of these is ovarian cancer—also known as “the silent killer,” since it is usually diagnosed at an advanced stage. Ovarian cancer is the leading cause of reproductive tract cancer deaths in women, explained Dr. Minchew. Dr. Minchew has worked as a women’s health nurse practitioner since 2000, surveying patients for cancer and managing primary care issues. Since beginning her work in gynecologic oncology, she has provided a program of survivorship for patients who have recently completed their cancer treatments. Women treated for uterine and cervical cancers are often referred to Dr. Minchew for menopausal symptoms, sexual dysfunction and emotional issues related to treatment, as well as familial cancer risk assessment.
“I think this program is going to be a beautiful partnership between our patients and their health care team.” Both palliative care and survivorship begin at diagnosis and provide monitoring of patients’ needs throughout, taking into account the patient’s culture, faith and support systems in order to provide individualized medical, psychosocial and spiritual support. While
survivorship helps the patient deal with the long-term effects of treatment, palliative care is concerned with improving quality of life by managing treatment side effects such as pain, nausea, dehydration and toxicities related to chemotherapy or radiation. Palliative care continues throughout treatment until hospice is needed. While there are similarities in the overall process of care, palliative care also differs from hospice care. Palliative care addresses the patient’s immediate needs to improve quality of life during cancer treatment when symptoms may become overpowering. Hospice, on the other hand, helps to improve quality of life during the final months and weeks of life. Palliative care assessments incorporate the difficult discussions about end of life care to insure patients’ personal desires are met through mutual understanding between the patient, provider and caregiver. Discussions regarding advance directives, selecting individuals to assist in decision-making related to end of life decisions when the patient cannot speak for herself and coping through treatment by anticipating and reducing suffering are included. “These are difficult conversations to have,” said Dr. Minchew. “Although everyone should plan for the challenging decisions at the end of life, we especially desire for our patients to feel empowered to voice their wishes early in the treatment process.” When Dr. Minchew meets with patients for an initial assessment, she and the patient set personal goals for care, discussing the patient’s individual expectations of the cancer treatment plan and potential side effects. During the ENABLE Project, Dr. Minchew will provide weekly follow-up with the patient for six weeks. Additionally,
she will provide individualized support and follow-up to the caregiver for the first three weeks. “Caregivers are often overwhelmed,” explained Dr. Minchew, “and need separate but equal support to help them anticipate the patient’s needs while remembering to take care of themselves.” After the initial followup period, contact with both the patient and caregiver will continue on a monthly basis and includes bereavement counseling when needed. Dr. Minchew’s position allows her extended visits with patients to explain various complimentary therapies that may benefit them. “I have the opportunity to spend time with patients and really get to know them,” she said. “Everything I do is individualized.” Through this direct contact, palliative care encourages patients to be fully involved in treating symptoms, understanding the surgical process and setting realistic expectations. As a complement to MCI’s survivorship program, Dr. Minchew explained that palliative care delivered in conjunction with treatment or therapy can provide a higher quality of life for cancer patients and their support systems. While the ENABLE Project begins this summer and runs for one year, MCI is committed to an ongoing palliative care program and hopes to expand the program to other service teams. Dr. Minchew has a special interest in this palliative care grant opportunity. After her mother was diagnosed with ovarian cancer in 2006, she witnessed the challenges of her mother’s care while watching her father fulfill the caregiver role. This gives her a greater empathy for her patients and their caregivers, and first-hand experience in the cancer treatment process.
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M
GE PRES A L EN F O T N IO AT
CH E
OUTREACH
Unmask Cancer Challenges
D
ynamic cancer “thriver� Cookie Aftergut took the stage on Feb. 27 to give an audience of cancer patients and others encouragement and practical tips about the challenges of being a new chemotherapy patient.
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Aftergut is the founder of Chemoflage, a non-profit educational program geared toward women who have recently been diagnosed with cancer and are undergoing chemotherapy. The Chemoflage program, sponsored by MCI, was held at the University of South Alabama Faculty Club.
Cookie Aftergut at the USA Faculty Club.
The patients, supporters and cancer professionals in attendance were treated to Aftergut’s energetic and straightforward approach to dealing with cancer, which was laced with humor. She discussed the pitfalls of chemotherapy, including the short-term memory loss known as “chemo brain.” She dispensed practical advice like using hand-sanitizer liberally since the immune system is non-existent during treatment.
T.A.A.P.P. Aftergut shared her acronym TAAPP, which is her advice for cancer patients. The “T” stands for taking timeout for yourself. The first “A” is for attitude, for
making the best of a bad situation. The second “A” is for act, as in act on it. To combat chemo-brain, if you think of something you need to do, act on it by doing it or writing a reminder on a post-it note. The first “P” is for patience through the process and the final “P” is permission to let others help. The Faculty Club program also included a short segment highlighting spring and summer 2014 fashion trends. Participants also received information about a variety of topics, including nutrition, relaxation techniques, and emotional challenges. Aftergut, an 11-year cancer survivor, was the recipient of a Yoplait Champion award in 2006. She used the $1000 award to help found the Atlanta-based Chemoflage. She brings her program to cancer patients in the Atlanta area, in Houston and now in Mobile.
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OUTREACH
Taking a Message of Prevention
Into The Community Sometimes when you’re doing cancer prevention outreach you have to get creative. You have to meet people where they work, pray, and gather. MCI’s Associate Manager of Community Outreach, Lakeisha Felder, knows this well. She, along with other members of the team, are working to get the word out in the community about colorectal cancer prevention. MCI is part of the FITWAY ALABAMA initiative through the Alabama Department of Public Health encouraging early detection of colorectal cancer, the number two cancer killer in the state. While deadly, it is also very treatable when detected in its earlier stages. After a successful launch at the University of South Alabama last summer to test employees over 50 using the non-invasive FIT (Fecal Immunochemical Test) test, MCI expanded its efforts. Recently, Evonik, with 700 employees, launched the screening program at their plant site in Theodore. G.A. West, a full-service construction organization with several locations in the Mobile area, launched a program in April. “While people are initially reluctant to discuss colorectal cancer, once they hear the statistics and understand how it affects their community, they become much more receptive,” says Felder.
The program recruited area shops to put out colorectal cancer information as well as talk with their customers about the testing. MCI provided awareness T-shirts, wristbands and literature for the effort. A local barbershop and salon, J. Maurice the Salon and Vincent’s Headquarters, even hosted Saturday community education events during the month drawing crowds with food, treats, and children’s activities, while dispensing information about prevention. Optimum Cuts and Styles, Headquarters Barber & Style Shop, Split Enz Styling Team 3 Barbers, Custom Cuts Barber Shop, Lucy’s Barbershop, Studio 17, and Five Star Barbershop also participated in the month-long program. Other participating businesses located in the Cottage 65 Plaza included: Subway, Nancy’s Nails, Harrison Finance, and Sufur Boutique. “We were encouraged by the response we got from the shops. The more the message gets out there, the more aware people are going to be about taking preventive measures to safeguard their health,” says Felder. To learn more about MCI’s colorectal cancer outreach programs contact the Community Outreach Team at 251-445-9819.
A church association with 23 member churches has also expressed interest in the prevention program. Felder adds, “It’s all about getting people at places where everyone goes.” That would include hair salons and barbershops. In March, during colorectal cancer awareness month, MCI partnered with the American Cancer Society on their “Let’s Go Blue” campaign and their innovative program “Shop Talk.”
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MCI’s Lakeisha Felder, front left and American Cancer Society’s Chelette Webster, front right, and the “Shop Talk” crew from Vincent’s Headquarters.
2nd Annual
From left to right: Dr. John Russell, Dr. Anthony Martino, Dr. John Fiveash, Dr. Ed Partridge, Dr. Richard Goldberg, Dr. Lee Grimm, Dr. Marcus Tan
Oncology
Outlook 2014 USA President, Dr. Tony Waldrop, wwith cancer survivor and keynote speaker, Michael Daves, at Cancer Survivor’s Day.
Over 600 people attended the second annual Cancer Survivors Day on June 1 in the Geri Moulton Children’s Park adjacent to the Mitchell Cancer Institute. MCI, Children’s & Women’s Hospital, and Ronald McDonald House Charities of Mobile hosted the event that featured free BBQ, entertainment, educational information for survivors, inspirational speakers and activities for the entire family. Free Magic Memories photos were also provided. The event was held as part of National Cancer Survivors Day, which is observed in hundreds of communities nationwide and around the world. It is a celebration of cancer survivors, inspiration for the recently diagnosed, support for families, and outreach for the community.
Internationally-renowned oncologists and physicians gathered in Point Clear, Alabama on March 14-15 to discuss the need for increased awareness of chemotherapeutic, radio therapeutic and surgical options in brain and colorectal cancer at Oncology Outlook 2014. Sponsored by USA Mitchell Cancer Institute and the University of South Alabama College of Medicine, the continuing medical education conference featured renowned speakers and physicians, such as gastrointestinal oncologist Dr. Richard Goldberg, physician in chief of the Ohio State Comprehensive Cancer Center, and Dr. Burton Nabors, director of the UAB Neuro-Oncology Program. Dr. Edward Partridge, Director of the UAB Comprehensive Cancer Center and the 2013 recipient of the prestigious American Cancer Society’s National Humanitarian Award, was the guest speaker for the Saturday luncheon. Physicians and faculty from UAB, the University of South Alabama, and MCI also presented on various topics to an audience of approximately 100 physicians, nurses and other health care professionals. The conference at the Marriott Grand Hotel was held during the 62nd Annual Arts and Crafts Festival in Fairhope, so attendees could enjoy the event during their free time. Dr. Anthony Martino, Chair of the USA Department of Neurosurgery served as the conference director. Next year’s event will be held March 21-22, 2015.
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OUTREACH
Spreading Love Through Hats It is a Tuesday in the infusion suite at Mitchell Cancer Institute. Sitting in recliners, chemotherapy patients have begun their treatment. Several women wear multi-colored caps to cover their bald heads, a gift from a former patient. These Love Hats are the creation of 76-year-old Norma Jean Stowe. Stowe, who “rang the bell” signaling the end of her treatment for breast cancer on May 6, struggled to find the right covering for her head after losing her hair to
chemo in early 2013. She eventually relied on her creativity and considerable sewing skills to craft a solution. But she didn’t realize there would be a demand for them until she wore her hat to the infusion suite and attracted some interest. With a little help from a friend, Jude Reynolds, Love Hats came into being. Since that time, she has made and given away more than 100 of the hats, which are made of soft cloth with a small bill and strips of cloth that tie in the back. She receives donations of fabric from fellow church members and others, and figures she’ll keep making them as Love Hat creator Norma Jean Stowe
A capacity crowd filled the Mitchell Cancer Institute’s lobby for the fourth annual Think Pink Tea on Oct. 24, 2013. Attendees bedecked in pink listened to speakers, enjoyed treats from Martha Rutledge Catering and watched the event’s first-ever fashion show. Several speakers delivered messages of hope and love. Dr. Elizabeth Chabner Thompson, a radiation oncologist and founder of the BFFL bag company, extolled the benefits of friendship when undergoing cancer.
2013
Geri Moulton recounted her cancer journey with her husband, President Emeritus Gordon Moulton, who lost his battle to cancer in September 2013. She shared his simple message relayed to her before he died: “If you hug me, I can do it.” This
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sentiment, she said, can be applied to all cancer patients. Moulton introduced 35-year old Erica Lambert, who survived Stage 3 breast cancer. Lambert praised her family and God for sticking by her during her cancer treatment. Dr. Windy Dean-Colomb provided words of hope and inspiration to those battling breast cancer. The highlight of the event was the fashion show featuring 22 models, four of whom were children. The group was made up of survivors, physicians and women who have been impacted by cancer in some way. Their escorts – Owen Bailey, Don Ching, Dr. Michael Finan, Dr. Rodney Rocconi and Plez Hendrix – represented the USA health system. Clothing was provided by Dillard’s of Bel Air Mall. Agency VERGE organized and implemented the show. MCI partnered with USA Children’s and Women’s Hospital on Think Pink Tea, which honors and celebrates breast cancer patients and survivors during Breast Cancer Awareness Month. Due to the overwhelming success of the event, the fifth annual Think Pink Tea will be moved to Geri Moulton Children’s Park this fall. Mark your calendars for Thursday, October 2nd.
long as she has fabric. And nothing is wasted. Stowe uses scraps from the hats to make cloth bags so patients have a place to carry their medicine. “People have been so generous,” she says. “It’s astonishing how this has taken off.” Helping people is natural for the energetic Stowe. A former secretary in the foreign service, she also serves as a volunteer guardian for the Mobile County Probate Court under a program started by Judge Don Davis. She is a lector at her church, Our Savior. As for the name Love Hats? “I make them in love and I give them to the ladies in love,” she replies. If you’re interested in donating material, Stowe can be reached at pianonana@bellsouth.net.
DEVELOPMENT PNC Funds
New Patient Assistance Program The PNC Foundation awarded a $25,000 grant to establish a patient assistance program at Mitchell Cancer Institute for patients and families struggling with the basic costs of cancer care and treatment. Cancer death rates along the Gulf Coast are some of the highest in the nation, with Mobile and Baldwin counties losing nearly 1,600 people annually to cancer. As the only academic cancer research facility in the region, MCI recorded more than 60,000 patient visits in 2013. A significant percentage of those individuals were from low-to moderate-income families. “Even if lower-income patients can maintain adequate health care, they often face financial instability and increased debt, which has major implications for patients and families, as well as our communities,” said Cedric Hatcher, PNC Gulf Coast regional president on behalf of the PNC Foundation.
Lower-income patients often view preventive screenings as an unnecessary expense, which means they seek treatment when their cancer is at a later stage where fewer treatment options are available and survival rates are lower. Once diagnosed, they do not always have the resources to meet basic needs such as physician visits, prescription and non-prescription drug coverage, medical devices and hospice care. The patient assistance program is designed to help reduce cancer disparities that exist among patients. The PNC Foundation gift will help cover supportive services such as transportation and prescription drug costs for patients. “This is the first major corporate gift for the patient assistance program, which will cover a range of critical costs to help lower-income patients and families both seek and comply with their cancer care and treatment,” said Dr. Ron Franks, vice president for health sciences and interim director of MCI. The donation from the PNC Foundation, which receives its principal funding from the PNC Financial Services Group, reflects its commitment to supporting organizations that provide services for the benefit of communities in which it has a significant presence.
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Donor Profile
Biobank Manager Paul Howell removes biomarker samples from a liquid nitrogen freezer.
E.E. Delaney Foundation Pledges
$100,000 to MCI The E. E. Delaney Foundation recently pledged a gift of $100,000 over five years to Mitchell Cancer Institute. The gift is designated for MCI’s Biomarker Discovery Research Fund.
Through biomarkers, great strides have been made in early detection. We wanted to support MCI’s lab dedicated to biomarker discovery, and were really impressed with the progress they have made.”
When the foundation met with MCI, Bobby Frost, the chief executive officer of Delaney Development, was particularly impressed with what they saw and heard.
A biomarker is a biological molecule found in blood, other body fluids or tissues that is a sign of the presence of a disease. At MCI, biomarker research development is the main research emphasis of the laboratory run by Dr. Lewis Pannell.
“When you’re in little old Mobile, Alabama, you don’t think you’re in a place that could cure cancer, but the researchers at MCI convince you otherwise,” he said. “And while they may not have a cure yet, that’s not all there is to it.
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“A biomarker is an early warning that something is wrong. In our case, we look for signals related to the presence of a cancer,” said
Dr. Pannell. “While there are no reliable early detection markers for some cancers like ovarian and pancreatic cancer, the research we are performing shows great promise in developing ways to detect these deadly forms of cancer sooner. We are working toward developing this into a test.” In 1982, the Delaney Family established the E. E. Delaney Foundation Inc., in memory of Mobilian E. E. “Bill” Delaney, the founder of the Delaney companies. The Delaney Foundation was created for the purpose of giving back to the community in the form of charitable contributions and scholarships.
DEVELOPMENT
RENT PINK benefits
MCI and Children’s & Women’s Hospital Thanks to a pink tractor, Beard Equipment Company in Mobile presented a check for $60,000 to the USA Mitchell Cancer Institute and USA Children’s & Women’s Hospital in November 2013. Through its RENT PINK project, Beard committed to donating the rental revenue for its pink tractor to cancer research for a year. “It’s one of the largest pieces of machinery in our fleet,” said Beard Advertising and Marketing Director Kristen B. DeLaney. “We thought that would be impactful.”
The program is in its third year. For the first year, the company focused on Mobile’s cancer hospitals. “Our company likes to support things in our community,” DeLaney said. “It’s the responsibility of all local businesses.” In year two, RENT PINK branched out to support the communities where Beard has its seven offices, with a focus on children’s cancers, including USA Children’s and Women’s Hospital. “It’s more than just raising funds,” DeLaney said. “For us, it’s about cancer awareness.”
Customer response to RENT PINK was overwhelming. Some rented the equipment to honor a family member battling cancer, while others rented the pink tractor even though they didn’t need it, but wanted to support the program. “Every office, every job site, every man, every woman, we all know someone with cancer,” said DeLaney. “It touches so many people.” In total, 22 customers participated.
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Event chairs, Kelly and Craig Fowler
Celebrate Hope 2013 Sponsors Presenting Sponsor
Celebrate Hope with Chef John Besh
- PNC Bank - Wells Fargo
Cellar Master - Beau Rivage Resort and Casino
More than 700 guests attended the fifth annual event - the Institute’s premier fundraiser which featured mouthwatering dishes prepared by local chefs and caterers. Award-winning celebrity chef Besh prepared one of his culinary masterpieces and signed copies of his new cookbook, “Cooking from the Heart.” Half of the proceeds from the sale of his cookbook were donated to MCI. In addition to food and beverage pairings, live entertainment was provided by Tayo Reed Explosion. For the
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Proceeds went to purchase a mass spectrometer, the Thermo Electron Q-Exactive Nano-LCMS system, for the Mass Spectrometry and Proteomics Core Laboratory at MCI. The lab provides researchers with technology to identify and characterize proteins for the early detection of cancer. The system was installed at MCI in May. A Premiere Partner event for sponsors was held in January at the Beau Rivage Resort and Casino in Biloxi, Mississippi, featuring headliner Vince Gill. The sixth annual Celebrate Hope will be held on Nov. 20, 2014. Michael and Catherine Druhan will serve as chairs for the event.
- Alabama Crown - Aramark-USA Dining Services
- Abraham A. Mitchell
- Bay Shore Finance Inc.
- Mrs. Arlene Mitchell
second year in a row, the event was chaired by Kelly and Craig Fowler.
Grand Sommelier
- Louis and Melinda Mapp
- Press-Register
Famed New Orleans chef John Besh was the highlight of a sold-out Celebrate Hope 2013, presented by CNC Claims, held on Nov. 21 at Mitchell Cancer Institute. The event raised more than $379,000 toward equipment purchases for MCI.
- Mr. and Mrs. Walter Davis Pilot
Chef de Cave - Agency VERGE - Gulf Distributing Company of Mobile LLC - Lexus of Mobile - Mobile Gas, A Sempra Company - PCI Gaming Authority - Mr. and Mrs. Russell R. Steiner
- Blue Rents Inc. - Mr. and Mrs. Richard Bounds - Braintree Laboratories Inc. - Lisa and Barry Bukstein - Callis Communications - CIMCO Refrigeration Inc. - E.E. Delaney Foundation Inc. - Genentech
- USA Foundation
- Infirmary Health System
Wine Maker
- Cindy and Richard Lacey
- Mobile Airport Authority
- Laureen H. Lynn
- Mobile Firefighters Association - Aloyis L. Sonneborn
Enophile
- Barbara and Bernard Malkove - My Covered Drugs - Ashley and Wesley Naile
- Anonymous
- P & G Machine & Supply Co. Inc.
- Cox Nuclear Pharmacy LLC
- Page & Jones Inc./ Michael Lee
- Florence Foundation
- Ruland & Ruland CPAs LLC
- Audrey and Max Goldberg - Hoar Program Management - Laura and Ben Meisler
- Smith, Dukes and Buckalew LLP - Gail and Kenny Sylvester - Zimlich the Florist Inc. /Dennis C. Harris, AIFD, CAFA
DEVELOPMENT
Point Clear Charities Inc.
Supporting MCI Research Point Clear Charities Inc. has been a dedicated supporter of MCI for many years. Through their premier charity sporting event, Polo at the Point, they have raised funds and awareness for the Institute and a variety of area charities and causes. On Feb. 6, in a presentation at Sonny Hill Farm in Fairhope, MCI received $75,000 from the charity to support novel research in acute myelogenous leukemia. The disease is responsible for nearly 15 percent of all pediatric forms of leukemia. “MCI values the partnership with Point Clear Charities and their commitment to advancing pediatric cancer research throughout the region,” said Kelly McCarron, Director of Development at MCI. “We are humbled by the generosity of those supporting these events that make this research possible.”
The 25-year-old Polo at the Point, last held on Oct. 26, 2013, is a world-class polo event and party that features gourmet cuisine, champagne, divot stomping, tailgating, and distinctive millinery. This year, the organization added another event which celebrates style, the Fairhope Fête, a “week of global fashion.” Proceeds totaling $181,000 from these two successful events were given out to 14 beneficiaries at the presentation, including MCI. Point Clear Charities has raised more than $5 million for charity over the last 25 years. The Point Clear Charities Board, the Polo at the Point Committee, and the dedication and direction of event Chairs Linda Lou Parsons and Dawn Pilot make the two events a reality.
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Upcoming
EVENTS 09.20.14
GO RUN Sept. 20 at the Mitchell Center/Moulton Tower Lawn on USA Main Campus. To register or learn more visit www.usamci.com/gorun
09.27.14
Cash for Cancer Sept. 27 - Fundraiser in memory of Jim “Cash” McConnell at Dennis Lake in Bay Minette, Alabama. It is based around a Five Stand Clay Target Tournament “Skeet Shoot.” For more information follow Cash for Cancer on Facebook.
10.26.14
Tennis for Tatas Oct. 26 at Mobile Tennis Center. All money raised goes to Breast Cancer Research at MCI. For more information contact Kori Saucier at 460-6209 or ksaucier@southalabama.edu.
11.01.14
10.02.14
Think Pink Tea Oct. 2 from 4:00 – 6:00 p.m. at Geri Moulton Children’s Park
Salty Worm Brackish Classic and Delta Bash Nov. 1 at Bluegill Restaurant. Benefits the Gaillard Pancreatic Cancer Research Endowment. For more information contact Kori Saucier at 460-6209 or ksaucier@southalabama.edu.
10.11.14
11.20.14
Kerri Castello Tennis Tournament Oct. 11 at The Country Club of Mobile. For more information visit www.servinghope.com/
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10.18.14
Polo at the Point- Oct. 18 at Sonny Hill-Clearwater Polo Complex in Point Clear. For more information visit www.poloatthepoint.com/
Minds Conquering Cancer | Summer 2014
Celebrate Hope Nov. 20 at MCI. www.usamci.com/celebratehope
Greater hope is in site.
Non-Profit Non-Profit U.S. Postage Postage U.S. PAID PAID Mobile, AL AL Mobile, Permit No. No. 506 506 Permit
USA Mitchell Mitchell Cancer Cancer Institute Institute USA 1660 Springhill Springhill Avenue Avenue 1660 Mobile, AL AL 36604-1405 36604-1405 Mobile,
For appointments appointments call: call: For (251) 665-8000 665-8000 or or (251) 1-800-330-8538 1-800-330-8538 To learn learn more more about about our our To clinical services services see see our our website: website: clinical www.usamci.com www.usamci.com
UpCOMINg MCI EVENTS September 17, 2011
4th Annual GO for Gynecologic Oncology 5K/1 Mile Fun Run/Walk 8:00 a.m. USA Main Campus Mitchell Center Lawn Benefits GYN cancer research
October 23, 2011
2nd Annual Tennis for Tatas 1:00 p.m. Mobile Tennis Center Benefits breast cancer research
October 27, 2011 October 18, 2011
5th Annual Eastern Shore Toyota and Eastern Shore Hyundai Golf Tournament 11:00 a.m. Timbercreek Golf Club Daphne, Alabama Benefits Shawn and Leyla Esfahani Breast Cancer Research Endowment
Stay connected to the MCI. Scan with your smartphone or visit us at www.usamci.com (Download aa free free QR QR code code reader reader application) application) (Download
Minds Conquering Cancer | Summer 2014
follow us on facebook: USA Mitchell Cancer Institute
2nd Annual Think Pink Tea 4 – 6 p.m. Mitchell Cancer Institute Co-sponsored by Infirmary Health System
November 17, 2011
3rd Annual Celebrate Hope gala 6:00 p.m. Mitchell Cancer Institute Benefits cancer research
for more information on how you can sponsor, participate or volunteer for MCI Special Events, please contact Abbie McCullough at 251-460-7032 or e-mail amccullough@usouthal.edu Visit our Website: www.usamci.com/specialevents