MANAGEMENT OF DRUG-RESISTANT TUBERCULOSIS — MODULE C

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MODULE  C

3.5 Make referral to Treatment Center physician as necessary for moderate or severe ADRs If a patient has one of the moderate to severe ADRs listed in table 4, a physician should examine the patient immediately to take proper action. Refer the patient to a physician at the Treatment Center for care and follow-up. Table 5 Moderate to Severe ADRs

Adverse Reactions Acute renal failure

Suspected Agents S, Km, Am, Cm

Suggested Management • • • •

Discontinue suspect drug. Consider using Cm if an aminoglycoside had been the prior injectable in the regimen. Consider dosing 2 to 3 times a week if drug is essential to the regimen and patient can tolerate (close monitoring of creatinine). Adjust the dose according to creatinine clearance. See Annex A: Recommended Dosages.

Bartter-like syndrome (decrease in serum potassium, magnesium and calcium)

Cm, Km, Am, S

• •

Check electrolytes (K, Mg, Ca). Replace electrolytes as needed.

Generalized hypersensitivity (Stevens-Johnson syndrome)

Any drug

Withdrawal of the drugs and refer to specialist.

Hearing loss

S, Km, Am, Cm, Clr

Document hearing loss and compare with baseline audiometry if available. change parenteral treatment to Cm if appropriate (no resistance confirmed or suspected). Increase frequency and/or lower dose of suspected agent if this can be done without compromising the regimen. Discontinue suspected agent if this can be done without compromising the regimen.

• • • Hemolysis

R

Discontinue drug and referral to specialist

Hepatitis/jaundice

Z, H, R, Eto/Pto, PAS, E, FQ

Discontinue therapy pending resolution of hepatitis. Eliminate other potential causes of hepatitis. Consider suspending most likely agent permanently. Reintroduce remaining drugs, one at a time with the most hepatotoxic agent first, while monitoring liver function.

• •

Hypothyroidism

PAS, Eto/Pto

Initiate thyroxine therapy.

Intractable vomiting

Eto/Pto, PAS, H, E, Z

Assess for dehydration, initiate rehydration if indicated. Divide the dose (AM and PM) as long as it is supervised. Discontiue suspected agent if this can be done without compromising the regimen.

• • Optic neuritis

78  Treat MDR-TB Patients

E

Discontinue drug and refer to ophthalmologist.


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