ENOTprost for male wellness

Let prostate problems fly away with the right ingredient. ENOTprost ® has proven strong antioxidant and anti-inflammatory activities

Prostatic ailments are among the most common urologic problems in adult males. BPH (benign prostatic hyperplasia) is the third most frequent urologic diagnosis in men over 50, although prostatitis can also affect young people, especially sportsmen and cyclists. Prostatic ailments share inflammation and oxidative stress as risk factors and cause of chronicity.

Epilobium

Epilobium angustifolium L. (Onagraceae) is a well-known European plant traditionally used for prostatic ailments such as prostatitis and BPH. ENOTprost ® from EPO Srl is a dry ex tract with a very rich phytocomplexcontaining more than 15 % of Oenothein B. It is a strong anti-inflammatory and antioxidant ingredient for innovative food supplements. The metabolic profile of ENOTprost ® was studied simulating the oro-gastroduodenal digestion and the gastroresistant oral administration (duodenal digestion). In this latter case, the

RT=0.00-149.98

Oenothein B

phytocomplex variety and chemical profile was very similar to the native extract. The digested extract still contained 20 compounds, among which there were organic acids, hydroxycinnamic acids and many flavonols. Moreover, miquelianin, the major flavonoid glycoside that only characterises the E. angustifolium species, was identified in the digested extract.

Strong anti-inflammatory activity

In vitro tests demonstrated that pretreatment of prostatic cells with ENOTprost ® followed by lipopolysaccharide induced inflammation, strongly reduces TNF-α production. TNF-α is one of the most important pro-inflammatory cytokines.

Enotprost ® enhances cellular antioxidant defence

In vitro tests demonstrated that treatment of prostatic cells with ENOTprost ® enhances cellular antioxidant defences by increasing the level of SOD1. This enzyme is one of the most important endogenous antioxidant defence mechanisms.

References

1. Granica S et al. Phytochemistry, pharmacology and traditional uses of different Epilobium species (Onagraceae): A review. Journal of Ethnopharmacology, 156, 316–346, 2014 2. Schepetkin IA et al. Therapeutic Potential of Polyphenols from Epilobium Angustifolium (Fireweed). Phytother Res, 30, 1287-1297, 2016

EPO extracts

• Manufacturing process entirely made in Italy. • Full traceability from the field to the final packaging • Botanical species certified by

DNA barcoding analysis • No harmful solvents used in the manufacturing process

Ctrl-: not inflamed and not treated cells Ctrl+: inflamed but not treated cells with ENOTprost Ctrl ENOTprost: not inflamed and not treated cells ENOTprost: pre-treated with ENOTprost and inflamed cells

Ctrl: not treated cells Enotprost: pre-treated with ENOTprost and inflamed cells

3. Vv.Aa. Anti-inflammatory and anti-oxidant activities of a new E. angustifolium dry extract - unpublished data 4. Paulis G. Inflammatory mechanisms and oxidative stress in prostatitis: the possible role of antioxidant therapy. Res Rep Urol, 10, 75-87, 2018

Sharp PS - a partner for the growing nootropic market

Looking to add a cognitive position to your product? Phosphatidylserine is clinically proven to support cognition

As we reach the third decade of the 21st century, it is increasingly evident that the population is aging 1 . For people and societies alike, healthy, successful aging becomes an increasingly important issue. After the age of 50, many start to suffer from agerelated cognitive decline also known as age-related memory impairment (AAMI).

Phosphatidylserine, PS for short, is a building block of cell membranes, found in all living cells. PS is also a natural component of our food. A human first consumes PS when it suckles from its mother, because human milk contains PS among other phospholipids. Every food from biological origin (fruits, vegetables, meat and fish) contains some PS, though levels are relatively low. The average consumption of PS through regular diet is estimated to be around 130 mg per day. Nonetheless, for specific populations, such as vegan or vegetarians and children, the estimation is much lower 2 . Thus, for many, supplementation with PS is the only way to ingest 100-300 mg per day, the amount, on top of regular diet, that is shown to be clinically effective.

Supplementation with PS can have benefits for human cognition

An interesting fact about PS is that it is especially enriched within the brain, up to 6 times more so than in any other tissue. 3 This fact intrigued researchers to examine the role of PS within the brain, leading to years of research which in turn led to a clear understanding that supplementation with PS can have certain benefits for human cognition. Benefits of PS consumption are not immediate, it is not a cognitive booster, but improvement can be seen over time. Unlike cognitive boosters, working quickly but for a short period of time, the effect of PS builds up and is sustained over time, so people may benefit from its consumption over the long run. This fact about PS ingestion was shown in Japanese elderly, who consumed PS or a placebo, for a period of 6 months. After 6 months, the participants stopped taking the supplement but returned to be tested three months later. The results, shown in the figure below, demonstrate that even three month after supplementation... >>

Test for cognitive function

n = 48 Age 50-69 100 mg PS per day

*p<0.01 (relative to baseline) **p<0.01 (relative to placebo)

3 months of treatment

6 months of treatment

follow-up (3 months post treatment)

Figure 1: Effects of PS supplementation on memory of elderly participants with memory complaints was tested over 6 months with 3 months follow-up. Ingestion of 100 mg/day PS was shown to be effective even 3 months after termination of the study (grey bars) 4 .

of PS stopped, the study participants still benefited from its earlier consumption, while results of those in the placebo group returned to baseline 4 :

Cognitive health is not just for the elderly

The usage of ingredients with cognitive effect is not limited to the adult population. From young children whose parents are looking to support their physical and mental development, through students who need to be focused in their learning, adults in a demanding work environment and, of course, elderly who may worry about age-related cognitive decline - many are looking for cognitive support. Some even look for cognitive support to their aging pets. Benefits of PS to various populations, including the pet population, have all been demonstrated in clinical studies.

Nootropics – moving to new delivery formats

Today, many people prefer to take their nootropics not through classic supplements such as capsules or soft gels, but rather through “regular” food consumption. Take, for example, the rise of the gummy delivery system. While these solutions do not fall under “standard food” category, but rather a different segment of supplements, the number of solutions available in gummy format, and the shelf space accommodating these products, is sharply increasing, as people move away from traditional supplements delivery formats. Moreover, traditional food companies are also increasingly looking to add functionality to their products, including the

addition of nootropics. Thus, the trend of foods with cognitive functionality is becoming ever more significant.

Add a cognitive position to your food product

Sharp●PS is a high-quality phosphatidylserine that is clinically proven to have a cognitive effect. It is regulated, for food and for supplement use, throughout the world. For example, Sharp●PS is generally recognised as safe, or GRAS 5,6 , making it a perfect partner for global companies seeking to add a cognitive position to their food products. The ingredient is available from various sources including soy, sunflower (Sharp●PS Green, a soy-free alternative) and fish (Sharp●PS Gold, a version conjugated to DHA) and different grades (powder, fine powder and patented dispersion for soft gels) to fulfil any need. Sharp●PS is particularly suitable for use in food, including dairy products and breakfast cereals. One characteristic of PS making it suitable for foods is the lack of organoleptic issues (taste, smell or mouthfeel). Another interesting characteristic of PS is that it is an amphipathic molecule, meaning it has both water soluble and oil soluble parts. This makes PS especially useful in foods which are water and oil emulsions such as dairy products or chocolates.

References

1. UN. (ed United Nations Department of Economic and Social Affairs) (2002). 2. Hamm, M. Nutritional-scientific statement on the change of nutritive provision with phosphatidylserine. (2002).

Approved cognition claim in the US

The body of scientific evidence has led the US FDA to accept in 2003 two qualified health claims for the ingredient:

“Consumption of Phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly”; and

“Consumption of Phosphatidylserine may reduce the risk of dementia in the elderly” These claims come with a disclaimer that “very limited and preliminary scientific research suggests that phosphatidylserine may reduce the risk of cognitive dysfunction/dementia in the elderly. FDA concludes that there is little scientific evidence supporting this claim”. 7

To this day, phosphatidylserine is the only ingredient with approved cognitive claims in the US.

3. Svennerholm, L. Distribution and fatty acid composition of phosphoglycerides in normal human brain. J Lipid Res 9, 570-579 (1968). 4. Kato-Kataoka, A. et al. Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. J Clin Biochem Nutr 47, 246-255, doi:10.3164/jcbn.10-62 (2010). 5. FDA. GRN No. 223: GRAS notice for phosphatidylserine, http://www.accessdata.fda.gov/ scripts/fcn/ fcnDetailNavigation.cfm?rpt=grasListing&id=223 (2007). 6. FDA. (2015). 7. FDA. Phosphatidylserine and Cognitive Dysfunction and Dementia (Qualified Health Claim: Final Decision Letter http://www.fda.gov/Food/ IngredientsPackagingLabeling/LabelingNutrition/ ucm072999.htm (2003).

Alsiano Food & Healthcare Team

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HealthcareNews is published 1-2 times a year and distributed to customer and other interested parties. Reproduction of articles appearing in HealthcareNews requires prior consent form the author. Alsiano is not responsible for the content of articles written by external authors. Publisher: Alsiano A/S Circulation: 400 copies Editor-in-chief: Lene Aarøe Nissen Coordinator, text, layout: Dorthe Andersson