2 minute read
IS IT LEMS OR MG?
Lambert-Eaton myasthenic syndrome (LEMS) and myasthenia gravis (MG) share several hallmark signs and symptoms, including muscle weakness and oculobulbar involvement 1,2
One way to differentiate these two immune-mediated neuromuscular disorders is to look for these specific signs and symptoms 1,2 :
LEMS MG
Symmetrical muscle weakness
Typically asymmetrical muscle weakness
Caudal-to-cranial pattern of spread
Late-onset and mild oculobulbar involvement
Absent or diminished tendon reflexes
Cranial-to-caudal pattern of spread
Early and prominent oculobulbar involvement
Preserved tendon reflexes
Autonomic dysfunction
Transient improvement of muscle strength with exercise, with fatigue that follows
Antibodies to voltage-gated calcium channels (VGCC) are usually found
No autonomic dysfunction
Muscle weakness worsens with exercise
Antibodies to AChR or MuSK are usually found
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Family & Prayer Room
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Exhibit Hall
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