Targeted Cancer Drug for Breast, Gastroesophageal, and Gastric Cancers

History of Trastuzumab Trastuzumab (Herceptin) falls under the monoclonal antibody in order to treat breast cancer and stomach cancer. Trastuzumab specifically used for the treatment of cancer that is HER2 receptor +Ve. Trastuzumab 440 mg was first originated by scientists named Dr. Axel Ullrich and Dr. H. Michael Shepard at Genentech, Incorporation in South San Francisco, CA. The initial invention with reference to neu oncogene by the lab of Robert Weinberg and the monoclonal antibody acknowledge the oncogenic receptor by the lab of Mark Greene also contributed to the formation of HER2 targeted therapies.

Genentech originated trastuzumab jointly with UCLA, starting the first clinical trial with 15 women in the year of 1992.

By the year of 1996, the clinical trials had expanded to more than 900 women, but due to pressure from advocates based on early success, Genentech worked with the Food and Drug Administration in order to begin a lottery system enabling 100 women each quarter access to the medicine outside the trials.

In the month of September, 1998, Herceptin: Biotechnology Breakthrough in Breast Cancer wins approval by the Food and Drug Administration.

In the year of 2014, the Biocon Limited and its partner Mylan obtained the regulatory approval in order to sell the biosimilar, but Roche contested the legality of the approval; that litigation ended in the year of 2016, and Biocon and Mylan each introduced their own branded biosimilars.

In the month of November, 2006, the Food and Drug Administration approved trastuzumab for the Adjuvant treatment of HER2+Ve Node +Ve Breast Cancer.

In the month of October, 2010, the Food and Drug Administration approved trastuzumab For the treatment of HER2+Ve Metastatic Stomach Cancer.

The trastuzumab injection price in india is around 110700 INR for a bottle of 50 ml infusion, depending on the pharmacy or wholesaler you visit. Any WHO-GDP & ISO certified pharmaceutical wholesaler company would be best to buy trastuzumab.

Source: https://theindianpharma.wordpress.com/2021/04/29/history-of-trastuzumab/