Risk factors for antiresorptive drug-related osteonecrosis of the jaw

7 Small animal models for antiresorptive drug-related osteonecrosis of the jaw 53

James L Borke, Ezher H Dayisoylu, Stephan Zeiter

• Does small animal investigation make sense? • What are the opportunities and limitations of small animal investigation? • What are the advantages and disadvantages of small animal models of antiresorptive drug-related osteonecrosis of the jaw (ARONJ)? • What controversies exist concerning these small animal models? • Are there significant differences among the various small animal models of ARONJ? • Does jaw size matter?

8 Large animal models for antiresorptive drug-related osteonecrosis of the jaw 59

Matthew R Allen, Pit Voss, Christoph Pautke

• Can antiresorptive drug-related osteonecrosis of the jaw (ARONJ) be related in large animals? • Are animal models really necessary? • What are the advantages of using large animals versus rodents?