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interferon α) are central to antiviral immunity. When coronaviruses (or other viruses) invade the host, viral nucleic acid activates interferon-regulating factors like IRF3 and IRF7 which promote the synthesis of type I interferons (IFNs). PIMS / MIS-C Based on the information published so far, most patients were treated with high dose intravenous Immunglobulin (see Table 2) and corticosteroids (Verdoni 2020). More data are needed to determine the optimal treatment strategies for patients with MIS-C. DOI: Tim Niehues has received authorship fees from uptodate.com (Wellesley, Massachusetts, USA) and reimbursement of travel expenses during consultancy work for the European Medicines Agency (EMA), steering committees of the PENTA Paediatric European Network for Treatment of AIDS (Padua, Italy), the Juvenile Inflammatory Cohort (JIR) (Lausanne, Switzerland), and, until 2017, the FIND-ID Initiative (supported by the Plasma Protein Therapeutics Association [PPTA] [Brussels, Belgium]).
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COVID Reference ENG 006.9
