Reaxys
PubChem
eMolecules
LabNetwork
Reactions (13)
Substances (1)
Structure
Citations (15)
Structure/Compound Data Chemical Name: (+)-Modafinil Reaxys Registry Number: 9767971
Type of Substance: isocyclic Molecular Formula: C15H15NO2S Linear Structure Formula: C15H15NO2S Molecular Weight: 273.356 InChI Key: YFGHCGITMMYXAQ-IBGZPJMESA-N
N° of preparations All Preps | All Reactions 12 prep out of 13 reactions.
Available Data
N° of ref.
Identification Physical Data (12) Spectra (11) Bioactivity (14) Other Data (2)
15
1
Synthesize | Hide Details Find similar Chemical Names and Synonyms (+)-Modafinil, (+)-modafinil, (S)-modafinil, armodafinil, d-modafinil, modafinil, OMO1-020 Identification Substance Label (4) Label
Reference
SMOD
Krasulova, Kristyna; Siller, Michal; Holas, Ondrej; Dvorak, Zdenek; Anzenbacher, Pavel
Xenobiotica, 2016 , vol. 46, # 4 p. 315 - 324 Title/Abstract Full Text View citing articles Show Details
(S)-2
Cao, Jianjing; Slack, Rachel D.; Bakare, Oluyomi M.; Burzynski, Caitlin; Rais, Rana; Slusher, Barbara S.; Kopajtic, Theresa; Bonifazi, Alessandro; Ellenberger, Michael P.; Yano, Hideaki; He, Yi; Bi, Guo-Hua; Xi, Zheng-Xiong; Loland, Claus J.; Newman, Amy Hauck
Journal of Medicinal Chemistry, 2016 , vol. 59, # 23 p. 10676 - 10691 Title/Abstract Full Text View citing articles Show Details
(S)(+)-3
Prisinzano, Thomas; Podobinski, John; Tidgewell, Kevin; Luo, Min; Swenson, Dale
Tetrahedron Asymmetry, 2004 , vol. 15, # 6 p. 1053 - 1058 Title/Abstract Full Text View citing articles Show Details
(+)(S)-1
Osorio-Lozada, Antonio; Prisinzano, Thomas; Olivo, Horacio F.
Tetrahedron Asymmetry, 2004 , vol. 15, # 23 p. 3811 - 3815 Title/Abstract Full Text View citing articles Show Details
Physical Data Melting Point (2) Melting Point
Solvent (Melting Point)
152.5 154 °C
di-isopropyl ether
Location
Reference
supporting information
Cao, Jianjing; Prisinzano, Thomas E.; Okunola, Oluyomi M.; Kopajtic, Theresa; Shook, Matthew; Katz, Jonathan L.; Newman, Amy Hauck
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 1 p. 48 - 52 Title/Abstract Full Text View citing articles Show Details
Olivo, Horacio F.; Osorio-Lozada, Antonio; Peeples, Tonya L.
Tetrahedron Asymmetry, 2005 , vol. 16, # 21 p. 3507 - 3511 Title/Abstract Full Text View citing articles Show Details
158 159 °C
Density (1) Density
Measurement Temperature
Type (Density)
Reference
1.342 g·cm-3
19.85 °C
crystallographic
In, Yasuko; Tomoo, Koji; Ishida, Toshimasa; Sakamoto, Yasuhiko
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 10 p. 1186 - 1189 Title/Abstract Full Text View citing articles Show Details
Crystal Phase (1) Description (Crystal Phase)
Temperature (Crystal Phase)
Reference
Crystal structure determination
19.85 °C
In, Yasuko; Tomoo, Koji; Ishida, Toshimasa; Sakamoto, Yasuhiko
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 10 p. 1186 - 1189 Title/Abstract Full Text View citing articles Show Details
Crystal Property Description (1) Colour & Other Properties white
Location
Reference
supporting information
Cao, Jianjing; Prisinzano, Thomas E.; Okunola, Oluyomi M.; Kopajtic, Theresa; Shook, Matthew; Katz, Jonathan L.; Newman, Amy Hauck
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 1 p. 48 - 52 Title/Abstract Full Text View citing articles Show Details
Crystal System (1) Crystal System
Reference
monoclinic
In, Yasuko; Tomoo, Koji; Ishida, Toshimasa; Sakamoto, Yasuhiko
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 10 p. 1186 - 1189 Title/Abstract Full Text View citing articles Show Details
Interatomic Distances and Angles (1) Description
Comment (Interatomic Distances and Angles)
Reference
Interatomic distances and angles
Method of determination: Single crystal X-ray diffraction
In, Yasuko; Tomoo, Koji; Ishida, Toshimasa; Sakamoto, Yasuhiko
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 10 p. 1186 - 1189 Title/Abstract Full Text View citing articles Show Details
Optical Rotatory Power (4) Type (Optical Rotatory Power)
Concentration (Optical Rotatory Power)
Enantiomeric excess
Solvent (Optical Rotatory Power)
Optical Rotatory Power
Wavelength (Optical Rotatory Power)
Temperature (Optical Rotatory Power)
Location
Reference
[alpha]
1.032 g/100ml
[alpha]
100 %ee
supporting information
Cao, Jianjing; Prisinzano, Thomas E.; Okunola, Oluyomi M.; Kopajtic, Theresa; Shook, Matthew; Katz, Jonathan L.; Newman, Amy Hauck
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 1 p. 48 - 52 Title/Abstract Full Text View citing articles Show Details
chloroform
78.5 deg
589 nm
26 °C
1.0 g/100ml
CHCl3
79 deg
589 nm
22 °C
Olivo, Horacio F.; Osorio-Lozada, Antonio; Peeples, Tonya L.
Tetrahedron Asymmetry, 2005 , vol. 16, # 21 p. 3507 - 3511 Title/Abstract Full Text View citing articles Show Details
[alpha]
0.99 g/100ml
CHCl3
76.7 deg
589 nm
22 °C
Prisinzano, Thomas; Podobinski, John; Tidgewell, Kevin; Luo, Min; Swenson, Dale
Tetrahedron Asymmetry, 2004 , vol. 15, # 6 p. 1053 - 1058 Title/Abstract Full Text View citing articles Show Details
[alpha]
1.0 g/100ml
CHCl3
81 deg
589 nm
22 °C
Osorio-Lozada, Antonio; Prisinzano, Thomas; Olivo, Horacio F.
Tetrahedron Asymmetry, 2004 , vol. 15, # 23 p. 3811 - 3815 Title/Abstract Full Text View citing articles Show Details
Space Group (1) Space Group
Reference
4
In, Yasuko; Tomoo, Koji; Ishida, Toshimasa; Sakamoto, Yasuhiko
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 10 p. 1186 - 1189 Title/Abstract Full Text View citing articles Show Details
Spectra NMR Spectroscopy (10) Description (NMR Spectroscopy)
Nucleus (NMR Spectroscopy)
Chemical shifts
1H
Chemical shifts
Coupling Nuclei
Solvents (NMR Spectroscopy)
Frequency (NMR Spectroscopy)
Location
Reference
dimethylsulfoxided6
supporting information
Cao, Jianjing; Prisinzano, Thomas E.; Okunola, Oluyomi M.; Kopajtic, Theresa; Shook, Matthew; Katz, Jonathan L.; Newman, Amy Hauck
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 1 p. 48 - 52 Title/Abstract Full Text View citing articles Show Details
13C
dimethylsulfoxided6
supporting information
Cao, Jianjing; Prisinzano, Thomas E.; Okunola, Oluyomi M.; Kopajtic, Theresa; Shook, Matthew; Katz, Jonathan L.; Newman, Amy Hauck
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 1 p. 48 - 52 Title/Abstract Full Text View citing articles Show Details
Chemical shifts
1H
dimethylsulfoxided6
300 MHz
Ternois, James; Guillen, Frederic; Plaquevent, JeanChristophe; Coquerel, Gerard
Tetrahedron Asymmetry, 2007 , vol. 18, # 24 p. 2959 - 2964 Title/Abstract Full Text View citing articles Show Details
Chemical shifts
13C
dimethylsulfoxided6
75 MHz
Ternois, James; Guillen, Frederic; Plaquevent, JeanChristophe; Coquerel, Gerard
Tetrahedron Asymmetry, 2007 , vol. 18, # 24 p. 2959 - 2964 Title/Abstract Full Text View citing articles Show Details
Chemical shifts
1H
CDCl3
Olivo, Horacio F.; Osorio-Lozada, Antonio; Peeples, Tonya L.
Tetrahedron Asymmetry, 2005 , vol. 16, # 21 p. 3507 - 3511 Title/Abstract Full Text View citing articles Show Details
CDCl3
Olivo, Horacio F.; Osorio-Lozada, Antonio; Peeples, Tonya L.
Tetrahedron Asymmetry, 2005 , vol. 16, # 21 p. 3507 - 3511 Title/Abstract Full Text View citing articles Show Details
CDCl3
Olivo, Horacio F.; Osorio-Lozada, Antonio; Peeples, Tonya L.
1H
Chemical shifts
13C
1H
Tetrahedron Asymmetry, 2005 , vol. 16, # 21 p. 3507 - 3511 Title/Abstract Full Text View citing articles Show Details
Chemical shifts
1H
1H
Chemical shifts
13C
1H
dimethylsulfoxided6
Prisinzano, Thomas; Podobinski, John; Tidgewell, Kevin; Luo, Min; Swenson, Dale
Tetrahedron Asymmetry, 2004 , vol. 15, # 6 p. 1053 - 1058 Title/Abstract Full Text View citing articles Show Details
dimethylsulfoxided6
Prisinzano, Thomas; Podobinski, John; Tidgewell, Kevin; Luo, Min; Swenson, Dale
Tetrahedron Asymmetry, 2004 , vol. 15, # 6 p. 1053 - 1058 Title/Abstract Full Text View citing articles Show Details
dimethylsulfoxided6
Prisinzano, Thomas; Podobinski, John; Tidgewell, Kevin; Luo, Min; Swenson, Dale
Tetrahedron Asymmetry, 2004 , vol. 15, # 6 p. 1053 - 1058 Title/Abstract Full Text View citing articles Show Details
IR Spectroscopy (1) Description (IR Spectroscopy)
Reference
Bands
Olivo, Horacio F.; Osorio-Lozada, Antonio; Peeples, Tonya L.
Tetrahedron Asymmetry, 2005 , vol. 16, # 21 p. 3507 - 3511 Title/Abstract Full Text View citing articles Show Details
Bioactivity Pharmacological Data (14) 1 of 14
Comment (Pharmacological Data)
Bioactivities present
Reference
Prisinzano, Thomas; Podobinski, John; Tidgewell, Kevin; Luo, Min; Swenson, Dale
Tetrahedron Asymmetry, 2004 , vol. 15, # 6 p. 1053 - 1058 Title/Abstract Full Text View citing articles Show Details
Osorio-Lozada, Antonio; Prisinzano, Thomas; Olivo, Horacio F.
Tetrahedron Asymmetry, 2004 , vol. 15, # 23 p. 3811 - 3815 Title/Abstract Full Text View citing articles Show Details
In, Yasuko; Tomoo, Koji; Ishida, Toshimasa; Sakamoto, Yasuhiko
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 10 p. 1186 - 1189 Title/Abstract Full Text View citing articles Show Details
Olivo, Horacio F.; Osorio-Lozada, Antonio; Peeples, Tonya L.
Tetrahedron Asymmetry, 2005 , vol. 16, # 21 p. 3507 - 3511 Title/Abstract Full Text View citing articles Show Details
Ternois, James; Guillen, Frederic; Plaquevent, Jean-Christophe; Coquerel, Gerard
Tetrahedron Asymmetry, 2007 , vol. 18, # 24 p. 2959 - 2964 Title/Abstract Full Text View citing articles Show Details
Zhu, Hao-Jie; Wang, Jun-Sheng; Donovan, Jennifer L.; Jiang, Yan; Gibson, Bryan B.; DeVane, C. Lindsay; Markowitz, John S. European Journal of Pharmacology, 2008 , vol. 578, # 2-3 p. 148 - 158 Title/Abstract Full Text View citing articles Show Details
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2008/70143 A1, 2008 ; Title/Abstract Full Text Show Details
Gome, Boaz
Patent: US2009/48464 A1, 2009 ; Title/Abstract Full Text Show Details
Cao, Jianjing; Prisinzano, Thomas E.; Okunola, Oluyomi M.; Kopajtic, Theresa; Shook, Matthew; Katz, Jonathan L.; Newman, Amy Hauck
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 1 p. 48 - 52 Title/Abstract Full Text View citing articles Show Details
Stingl, Kerstin A.; Weiss, Katharina M.; Tsogoeva, Svetlana B.
Tetrahedron, 2012 , vol. 68, # 40 p. 8493 - 8501 Title/Abstract Full Text View citing articles Show Details
Ternois, James; Guillen, Frederic; Piacenza, Guy; Rose, Sebastien; Plaquevent, Jean-Christophe; Coquerel, Gerard
Organic Process Research and Development, 2008 , vol. 12, # 4 p. 614 - 617 Title/Abstract Full Text View citing articles Show Details
DEBREGEAS ET ASSOCIES PHARMA; Suplie, Pascal; Vivet, Philippe
Patent: US2015/73055 A1, 2015 ; Title/Abstract Full Text Show Details
Krasulova, Kristyna; Siller, Michal; Holas, Ondrej; Dvorak, Zdenek; Anzenbacher, Pavel
Xenobiotica, 2016 , vol. 46, # 4 p. 315 - 324 Title/Abstract Full Text View citing articles Show Details
CODEXIS, INC.; Ang, Ee Lui; Alvizo, Oscar; Behrouzian, Behnaz; Clay, Michael; Collier, Steven; Eberhard, Ellen; Fu, Fan Jaslyn; Song, Shiwei; Smith, Derek; Widegren, Magnus; Wilson, Robert; Xu, Junye; Zhu, Jun
Patent: US9267159 B2, 2016 ;
Title/Abstract Full Text Show Details
Cao, Jianjing; Slack, Rachel D.; Bakare, Oluyomi M.; Burzynski, Caitlin; Rais, Rana; Slusher, Barbara S.; Kopajtic, Theresa; Bonifazi, Alessandro; Ellenberger, Michael P.; Yano, Hideaki; He, Yi; Bi, Guo-Hua; Xi, Zheng-Xiong; Loland, Claus J.; Newman, Amy Hauck
Journal of Medicinal Chemistry, 2016 , vol. 59, # 23 p. 10676 - 10691 Title/Abstract Full Text View citing articles Show Details
2 of 14
3 of 14
4 of 14
5 of 14
6 of 14
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
Krasulova, Kristyna; Siller, Michal; Holas, Ondrej; Dvorak, Zdenek; Anzenbacher, Pavel
Xenobiotica, 2016 , vol. 46, # 4 p. 315 - 324 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
Cao, Jianjing; Slack, Rachel D.; Bakare, Oluyomi M.; Burzynski, Caitlin; Rais, Rana; Slusher, Barbara S.; Kopajtic, Theresa; Bonifazi, Alessandro; Ellenberger, Michael P.; Yano, Hideaki; He, Yi; Bi, Guo-Hua; Xi, Zheng-Xiong; Loland, Claus J.; Newman, Amy Hauck
Journal of Medicinal Chemistry, 2016 , vol. 59, # 23 p. 10676 - 10691 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
monoamine transporter binding affinity
Species or TestSystem (Pharmacological Data)
brain membranes of rat
Further Details (Pharmacological Data)
Ki related to: dopamine transporter
Type (Pharmacological Data)
Ki
Value of Type (Pharmacological Data)
7640 nmol/l
Reference
Cao, Jianjing; Prisinzano, Thomas E.; Okunola, Oluyomi M.; Kopajtic, Theresa; Shook, Matthew; Katz, Jonathan L.; Newman, Amy Hauck
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 1 p. 48 - 52 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
monoamine transporter binding affinity
Species or TestSystem (Pharmacological Data)
brain membranes of rat
Results
molecular target: dopamine transporter
Reference
Cao, Jianjing; Prisinzano, Thomas E.; Okunola, Oluyomi M.; Kopajtic, Theresa; Shook, Matthew; Katz, Jonathan L.; Newman, Amy Hauck
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 1 p. 48 - 52 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
monoamine transporter binding affinity
Species or TestSystem (Pharmacological Data)
brain membranes of rat
Concentration (Pharmacological Data)
<= 10 μmol/l
Results
no effect (related to serotonin transporter)
Reference
Cao, Jianjing; Prisinzano, Thomas E.; Okunola, Oluyomi M.; Kopajtic, Theresa; Shook, Matthew; Katz, Jonathan L.; Newman, Amy Hauck
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 1 p. 48 - 52 Title/Abstract Full Text View citing articles Show Details
7 of 14
8 of 14
9 of 14
10 of 14
Effect (Pharmacological Data)
monoamine transporter binding affinity
Species or TestSystem (Pharmacological Data)
brain membranes of rat
Concentration (Pharmacological Data)
<= 10 μmol/l
Results
no effect (related to norepinephrine transporter)
Reference
Cao, Jianjing; Prisinzano, Thomas E.; Okunola, Oluyomi M.; Kopajtic, Theresa; Shook, Matthew; Katz, Jonathan L.; Newman, Amy Hauck
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 1 p. 48 - 52 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
locomotor activity; effect on
Species or TestSystem (Pharmacological Data)
mouse
Concentration (Pharmacological Data)
30 - 300 mg/kg
Type (Pharmacological Data)
maximal locomotor activity
Value of Type (Pharmacological Data)
Ca. 450 counts/min
Reference
Cao, Jianjing; Prisinzano, Thomas E.; Okunola, Oluyomi M.; Kopajtic, Theresa; Shook, Matthew; Katz, Jonathan L.; Newman, Amy Hauck
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 1 p. 48 - 52 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
locomotor activity; effect on
Species or TestSystem (Pharmacological Data)
mouse
Concentration (Pharmacological Data)
30 - 300 mg/kg
Type (Pharmacological Data)
time for maximal activity
Value of Type (Pharmacological Data)
1 h
Reference
Cao, Jianjing; Prisinzano, Thomas E.; Okunola, Oluyomi M.; Kopajtic, Theresa; Shook, Matthew; Katz, Jonathan L.; Newman, Amy Hauck
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 1 p. 48 - 52 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
locomotor activity; effect on
Species or TestSystem (Pharmacological Data)
mouse
Concentration (Pharmacological
30 - 300 mg/kg
Data)
11 of 14
Type (Pharmacological Data)
dose for maximal activity
Value of Type (Pharmacological Data)
100 mg/kg
Reference
Cao, Jianjing; Prisinzano, Thomas E.; Okunola, Oluyomi M.; Kopajtic, Theresa; Shook, Matthew; Katz, Jonathan L.; Newman, Amy Hauck
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 1 p. 48 - 52 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
P-glycoprotein activity; inhibition of
Species or TestSystem (Pharmacological Data)
LLC-PK1/MDR1 cells
Concentration (Pharmacological Data)
10 - 100 μmol/l
Method (Pharmacological Data)
human P-glycoprotein overexpressing porcine kidney epithelial LLC-PK1 cells; after incubation with doxorubicin in the presence of title comp. for 1 h intracellular conc. of doxorubicin analyzed by HPLC
Further Details (Pharmacological Data)
control: 0.5percent dimethyl sulfoxide; positive control: PSC833 (2 μM), quinine (200 μM); P-glycoprotein negative parental LLC-PK1 cells used as negative control; efficiency of PSC833 was defined as 100percent
Comment (Pharmacological Data)
No effect
Reference
Zhu, Hao-Jie; Wang, Jun-Sheng; Donovan, Jennifer L.; Jiang, Yan; Gibson, Bryan B.; DeVane, C. Lindsay; Markowitz, John S. European Journal of Pharmacology, 2008 , vol. 578, # 2-3 p. 148 - 158 Title/Abstract Full Text View citing articles Show Details
12 of 14
Effect (Pharmacological Data)
P-glycoprotein activity; inhibition of
Species or TestSystem (Pharmacological Data)
LLC-PK1/MDR1 cells
Concentration (Pharmacological Data)
10 - 100 μmol/l
Method (Pharmacological Data)
human P-glycoprotein overexpressing porcine kidney epithelial LLC-PK1 cells; after incubation with rhodamine123 in the presence of title comp. for 1 h intracellular conc. of rhodamine123 analyzed by HPLC
Further Details (Pharmacological Data)
control: 0.5percent dimethyl sulfoxide; positive control: PSC833 (2 μM), quinine (200 μM); P-glycoprotein negative parental LLC-PK1 cells used as negative control; efficiency of PSC833 was defined as 100percent
Comment (Pharmacological Data)
No effect
Reference
Zhu, Hao-Jie; Wang, Jun-Sheng; Donovan, Jennifer L.; Jiang, Yan; Gibson, Bryan B.; DeVane, C. Lindsay; Markowitz, John S. European Journal of Pharmacology, 2008 , vol. 578, # 2-3 p. 148 - 158 Title/Abstract Full Text View citing articles Show Details
13 of 14
Effect (Pharmacological Data)
transport
Species or TestSystem (Pharmacological Data)
LLC-PK1/MDR1 cells
Concentration (Pharmacological Data)
20 μmol/l
Method (Pharmacological Data)
human P-glycoprotein overexpressing porcine kidney epithelial LLC-PK1 cells; after incubation with title comp. in the presence or absence of PSC833 (2 μM) for 1 h intracellular conc. of title comp. analyzed by HPLC
Further Details (Pharmacological Data)
control: 0.5percent dimethyl sulfoxide; positive control: doxorubicin, rhodamine123; P-glycoprotein negative parental LLC-PK1 cells used as negative control
Results
accumulation of title comp. in LLC-PK1 cells was higher than that in LLC-PK1/MDR1 cells; cotreatment with PSC833 increased (52.9percent) title comp. conc. in LLC-PK1/MDR1 cells, suggesting that P-glycoprotein might play role in transport of title comp.; fig.
Reference
Zhu, Hao-Jie; Wang, Jun-Sheng; Donovan, Jennifer L.; Jiang, Yan; Gibson, Bryan B.; DeVane, C. Lindsay; Markowitz, John S. European Journal of Pharmacology, 2008 , vol. 578, # 2-3 p. 148 - 158 Title/Abstract Full Text View citing articles Show Details
14 of 14
Effect (Pharmacological Data)
transport
Species or TestSystem (Pharmacological Data)
LLC-PK1/MDR1 cell monolayers
Concentration (Pharmacological Data)
5 μmol/l
Method (Pharmacological Data)
human P-glycoprotein overexpressing porcine kidney epithelial LLC-PK1 cells; title comp. loaded into B or A side of monolayers; incubation in the presence or absence of PSC833 (2 μM); title comp. in receiver compartment analyzed by HPLC
Further Details (Pharmacological Data)
control: 0.5percent dimethyl sulfoxide; B: basolateral; A: apical; Papp B-A/Papp A-B: apparent permeability coefficient for B-A/A-B direction; PSC833: selective P-glycoprotein inhibitor; reference: rhodamine123 (Papp B-A-to-Papp A-B ratio = 11.11)
Results
Papp B-A-to-Papp A-B ratio was 1.24 in the absence and 0.85 in the presence of PSC833; fig.
Reference
Zhu, Hao-Jie; Wang, Jun-Sheng; Donovan, Jennifer L.; Jiang, Yan; Gibson, Bryan B.; DeVane, C. Lindsay; Markowitz, John S. European Journal of Pharmacology, 2008 , vol. 578, # 2-3 p. 148 - 158 Title/Abstract Full Text View citing articles Show Details
Other Data Use (2) Use Pattern
Location
Reference
Pharmaceuticals
Page/Page column 6
DEBREGEAS ET ASSOCIES PHARMA; Suplie, Pascal; Vivet, Philippe
Patent: US2015/73055 A1, 2015 ; Title/Abstract Full Text Show Details
substitution treatment of cocaine addicts
Page/Page column 6
DEBREGEAS ET ASSOCIES PHARMA; Suplie, Pascal; Vivet, Philippe
Patent: US2015/73055 A1, 2015 ; Title/Abstract Full Text Show Details