4-Methyl-5-phenyl-4,5-dihydrooxazol-2-amine (4-MAR)

Page 1

Reaxys

PubChem

eMolecules

Reactions (9)

Yield

Substances (9)

Citations (6)

Conditions

References

1

Synthesize Find similar

Rx-ID: 5861787 Find similar reactions

aus entspr. α-Aminobenzylalkohol und Bromcyan;

McNeil Laboratories Inc.

Patent: US3161650 , 1963 ; Chem.Abstr., 1965 , vol. 62, # 10439e Full Text Show Details

/BRN= 100775/, NCBr (II), AcONa/MeOH;

Mc. Neil lab. Inc.,

Patent: US3278382 , 1959 ; Chem.Abstr., 1966 , vol. 65, # 18592a Full Text Show Details

/BRN= 107178/, SO2Cl2/CH2Cl2, reflux;

Mc. Neil lab. Inc.,

Patent: US3278382 , 1959 ; Chem.Abstr., 1966 , vol. 65, # 18592a Full Text Show Details

2-Amino-1-phenyl-propanol, Bromcyan;

McNeil Lab.

Patent: FR2448BE628803 , 19631963 ; Chem.Abstr., 1964 , vol. 61, # 9500h


Full Text Show Details

2

Synthesize Find similar

Rx-ID: 981854 Find similar reactions

Synthesize Find similar

With sodium acetate in methanol

Synthesize Find similar

Poos,G.I. et al.

Journal of Medicinal Chemistry, 1963 , vol. 6, p. 266 - 272 Full Text View citing articles Show Details

3

Synthesize Find similar

Rx-ID: 981893 Find similar reactions

Synthesize Find similar

With sodium acetate in methanol

Synthesize Find similar

Poos,G.I. et al.

Journal of Medicinal Chemistry, 1963 , vol. 6, p. 266 - 272 Full Text View citing articles Show Details

4

Synthesize Find similar

Rx-ID: 981894 Find similar reactions

With sodium acetate in methanol

Synthesize Find similar

Synthesize Find similar

Poos,G.I. et al.

Journal of Medicinal Chemistry, 1963 , vol. 6, p. 266 - 272 Full Text View citing articles Show Details


5

Synthesize Find similar

Rx-ID: 10379814 Find similar reactions

Stage #1: in ethanol

10 h; Heating; Stage #2: With thionyl chloride in chloroform

T=20°C; 4 h; Stage #3: in ethanol

8 h; Heating; Title compound not separated from byproducts;

Rx-ID: 10379819 Find similar reactions

72.5%

Synthesize Find similar

Synthesize Find similar

Cruz, Alejandro; Padilla-Martinez, Itzia Irene; Garcia-Baez, Efren V.; Contreras, Rosalinda

Tetrahedron Asymmetry, 2007 , vol. 18, # 1 p. 123 - 130 Title/Abstract Full Text View citing articles Show Details

Synthesize Find similar

Cruz, Alejandro; Padilla-Martinez, Itzia Irene; Garcia-Baez, Efren V.; Contreras, Rosalinda

Tetrahedron Asymmetry, 2007 , vol. 18, # 1 p. 123 - 130 Title/Abstract Full Text View citing articles Show Details

in ethanol

Heating;

A

B

Synthesize Find similar

Synthesize Find similar

Synthesize Find similar

Synthesize Find similar

Rx-ID: 10379820 Find similar reactions

Synthesize Find similar

Synthesize Find similar

7

B

Synthesize Find similar

6

A

24 h; Heating; Title compound not separated from byproducts;

Cruz, Alejandro; Padilla-Martinez, Itzia Irene; Garcia-Baez, Efren V.; Contreras, Rosalinda

Tetrahedron Asymmetry, 2007 , vol. 18, # 1 p. 123 - 130


Title/Abstract Full Text View citing articles Show Details

A

B

Synthesize Find similar

Synthesize Find similar

8

Synthesize Find similar

Synthesize Find similar

Rx-ID: 10379821 Find similar reactions

Cruz, Alejandro; Padilla-Martinez, Itzia Irene; Garcia-Baez, Efren V.; Contreras, Rosalinda

Tetrahedron Asymmetry, 2007 , vol. 18, # 1 p. 123 - 130 Title/Abstract Full Text View citing articles Show Details

Stage #1: 24 h; Heating; Stage #2: With sodium hydroxide in water

0.25 h;

9

Synthesize Find similar

Hide Experimental Procedure

Rx-ID: 25067989 Find similar reactions

E. R. Squibb and Sons, Inc.

Patent: US4311840 A1, 1982 ; Title/Abstract Full Text Show Details

4.a:(a) (a) Trans-4-methyl-5-phenyl-4,5-dihydro-2-oxazolamine By following the procedure of Example 2 (a) but substituting threo amino-alcohol dl-norpseudoephedrine for α-aminomethyl benzyl alcohol, then trans-4-methyl-5-phenyl-4,5-dihydro-2-oxazolamine is formed.


Turn static files into dynamic content formats.

Create a flipbook
Issuu converts static files into: digital portfolios, online yearbooks, online catalogs, digital photo albums and more. Sign up and create your flipbook.