Reaxys
PubChem
eMolecules
Bioactivities (2210)
LabNetwork
SigmaAldrich
Reactions (86)
Substances (70)
Structure
Targets (72)
Citations (1203)
Structure/Compound Data Chemical Name: alprazolam Reaxys Registry Number: 1223125
CAS Registry Number: 28981-97-7 Type of Substance: heterocyclic Molecular Formula: C17H13ClN4
Linear Structure Formula: C17H13ClN4
Molecular Weight: 308.77
InChI Key: VREFGVBLTWBCJP-UHFFFAOYSA-N
1
N° of preparations All Preps | All Reactions
Available Data
22 prep out of 83 reactions.
2 prep out of 2 reactions.
Target
N° of ref.
Druglikeness
Bioactivity
Identification Physical Data (42) Spectra (47) Other Data (612)
Show Targets
1179
Druglikeness
Identification Physical Data (1) Spectra (3) Other Data (1)
Show Targets
1
Highest Clinical Phase: Marketed
Synthesize | Show Details Find similar Chemical Name: alprazolam Reaxys Registry Number: 4552943
CAS Registry Number: 122652-56-6 Type of Substance: heterocyclic Molecular Formula: C17H13ClN4
Linear Structure Formula: C16(13)CH13ClN4
Molecular Weight: 309.759
InChI Key: VREFGVBLTWBCJP-KHWBWMQUSA-N
2
Synthesize | Show Details Find similar
Chemical Name: 8-chloro-1-methyl-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a] [1,4]diazepine
1 prep out of 1 reactions.
Druglikeness
Identification Physical Data (1)
Show Targets
1
no reactions.
Druglikeness
Identification
Show Targets
6
no reactions.
Druglikeness
Identification Physical Data (10) Spectra (1)
Show Targets
3
Reaxys Registry Number: 4054947
Type of Substance: heterocyclic Molecular Formula: C17H13ClN4*ClH Linear Structure Formula: C17H13ClN4*ClH Molecular Weight: 345.231
InChI Key: QPKRITZYLTZFKH-UHFFFAOYSA-N
no reactions.
Druglikeness
Identification Physical Data (1)
Show Targets
1
Reaxys Registry Number: 21850139
1 prep
Druglikeness
Show
1
Reaxys Registry Number: 1162491
CAS Registry Number: 51339-48-1 Type of Substance: heterocyclic Molecular Formula: C17H13ClN4
Linear Structure Formula: C16(14)CH13ClN4
Molecular Weight: 310.759
InChI Key: VREFGVBLTWBCJP-OZUIXNLOSA-N
3
Synthesize | Show Details Find similar Chemical Name: alprazolam-d5
Reaxys Registry Number: 30053688
Molecular Formula: C17H13ClN4
Linear Structure Formula: C17H8(2)H5ClN4
Molecular Weight: 313.73
InChI Key: VREFGVBLTWBCJP-ZXZAAQOOSA-N
4
Synthesize | Show Details Find similar Chemical Name: alprazolam dihydrate Reaxys Registry Number: 7504444
Type of Substance: heterocyclic Molecular Formula: C17H13ClN4*2H2O Linear Structure Formula: C17H13ClN4*2H2O Molecular Weight: 344.801
InChI Key: FBCSZZXMSGVNSP-UHFFFAOYSA-N 5
Synthesize | Show Details Find similar
6
Synthesize | Show Details Find similar
CAS Registry Number: 1246182-61-5 Molecular Formula: BH3O3*C17H13ClN4
Linear Structure Formula: BH3O3*C17H13ClN4
Molecular Weight: 370.603
InChI Key: KWJBIRGXXDRKQG-UHFFFAOYSA-N
out of 1 reactions.
Identification Physical Data (1)
Targets
Reaxys Registry Number: 21850149
Molecular Formula: C2H2O4*C17H13ClN4*H2O Linear Structure Formula: C2H2O4*C17H13ClN4*H2O Molecular Weight: 416.821
InChI Key: ZMZVSBHNNLSHKM-UHFFFAOYSA-N
1 prep out of 1 reactions.
Druglikeness
Identification Physical Data (2)
Show Targets
1
Reaxys Registry Number: 21850140
CAS Registry Number: 1246182-65-9 Molecular Formula: C6H6O2*C17H13ClN4
Linear Structure Formula: C6H6O2*C17H13ClN4
Molecular Weight: 418.882
InChI Key: MLDPXGRTDLBKNK-UHFFFAOYSA-N
1 prep out of 1 reactions.
Druglikeness
Identification Physical Data (1)
Show Targets
1
Chemical Name: Neurol pro
no reactions.
Druglikeness
Identification
Show Targets
2
1 prep
Druglikeness
Show
1
7
Synthesize | Show Details Find similar
8
Synthesize | Show Details Find similar
9
Synthesize | Show Details Find similar
Reaxys Registry Number: 30053218
Molecular Formula: C5H9NO2*C17H13ClN4
Linear Structure Formula: C5H9NO2*C17H13ClN4
Molecular Weight: 423.902
InChI Key: AZNNYCCFMKYVHQ-UHFFFAOYSA-N 10
Synthesize | Show Details Find similar Reaxys Registry Number: 21850141
Molecular Formula: C7H6O2*C17H13ClN4
Linear Structure Formula: C7H6O2*C17H13ClN4
Molecular Weight: 430.893
InChI Key: ZUSUYPYAYCZHRG-UHFFFAOYSA-N
out of 1 reactions.
Identification Physical Data (1)
Targets
Reaxys Registry Number: 21850150
Molecular Formula: C4H4O4*C17H13ClN4*H2O Linear Structure Formula: C4H4O4*C17H13ClN4*H2O Molecular Weight: 442.859
InChI Key: ULWQLQZVSXALTO-JITBQSAISA-N
1 prep out of 1 reactions.
Druglikeness
Identification Physical Data (1)
Show Targets
1
Reaxys Registry Number: 21850142
CAS Registry Number: 1246182-54-6 Molecular Formula: C7H7NO2*C17H13ClN4
Linear Structure Formula: C7H7NO2*C17H13ClN4
Molecular Weight: 445.908
InChI Key: DAIGPEBFCNCUFH-UHFFFAOYSA-N
1 prep out of 1 reactions.
Druglikeness
Identification Physical Data (1)
Show Targets
1
Reaxys Registry Number: 21850144
CAS Registry Number: 1246182-63-7 Molecular Formula: C6H7BO3*C17H13ClN4
Linear Structure Formula: C6H7BO3*C17H13ClN4
Molecular Weight: 446.701
InChI Key: UFTOCNVFDAYGGH-UHFFFAOYSA-N
1 prep out of 1 reactions.
Druglikeness
Identification Physical Data (1)
Show Targets
1
Chemical Name:
no reactions.
Druglikeness
Show
4
11
Synthesize | Show Details Find similar
12
Synthesize | Show Details Find similar
13
Synthesize | Show Details Find similar
14
Synthesize | Show Details Find similar
benzodiazepine alprazolam Reaxys Registry Number: 30711934
Molecular Formula: C9H8N2*C17H13ClN4
Linear Structure Formula: C9H8N2*C17H13ClN4
Molecular Weight: 452.946
InChI Key: ODTOFCRQKBDYLL-UHFFFAOYSA-N
15
Identification
Targets
Synthesize | Show Details Find similar Reaxys Registry Number: 21850147
CAS Registry Number: 1246182-55-7 Molecular Formula: C7H6O4*C17H13ClN4
Linear Structure Formula: C7H6O4*C17H13ClN4
Molecular Weight: 462.892
InChI Key: NVIHUKDCRSPOBH-UHFFFAOYSA-N
1 prep out of 1 reactions.
Druglikeness
Identification Physical Data (1)
Show Targets
1
Reaxys Registry Number: 21850145
Molecular Formula: C7H4F2O2*C17H13ClN4
Linear Structure Formula: C7H4F2O2*C17H13ClN4
Molecular Weight: 466.874
InChI Key: LVLFFGVUCRQHHN-UHFFFAOYSA-N
1 prep out of 1 reactions.
Druglikeness
Identification Physical Data (1)
Show Targets
1
Reaxys Registry Number: 21850146
Molecular Formula: C7H4F2O2*C17H13ClN4
Linear Structure Formula: C7H4F2O2*C17H13ClN4
Molecular Weight: 466.874
InChI Key: KMLFWJFZQXKREI-UHFFFAOYSA-N
1 prep out of 1 reactions.
Druglikeness
Identification Physical Data (1)
Show Targets
1
Reaxys Registry Number: 21850148
1 prep
Druglikeness
Show
1
16
Synthesize | Show Details Find similar
17
Synthesize | Show Details Find similar
18
Synthesize | Show Details Find similar
Molecular Formula: C6H8B2O4*C17H13ClN4
Linear Structure Formula: C6H8B2O4*C17H13ClN4
Molecular Weight: 474.519
InChI Key: KQPOOIUFVZWXFN-UHFFFAOYSA-N
out of 1 reactions.
Identification Physical Data (1)
Targets
Chemical Name: Arg Neurol
no reactions.
Druglikeness
Identification
Show Targets
9
Reaxys Registry Number: 21850143
CAS Registry Number: 1246182-67-1 Molecular Formula: C6H3Cl3O*C17H13ClN4
Linear Structure Formula: C6H3Cl3O*C17H13ClN4
Molecular Weight: 506.218
InChI Key: YKEZJGLBQOVQBN-UHFFFAOYSA-N
1 prep out of 1 reactions.
Druglikeness
Identification Physical Data (1)
Show Targets
1
Chemical Name: Alprazolam Imipramine
no reactions.
Druglikeness
Identification
Show Targets
1
no reactions.
Druglikeness
Show
1
19
Synthesize | Show Details Find similar
Reaxys Registry Number: 30089752
Molecular Formula: C6H14N4O2*C17H13ClN4
Linear Structure Formula: C6H14N4O2*C17H13ClN4
Molecular Weight: 482.973
InChI Key: GNNJFDBXVOEODM-UHFFFAOYSA-N
20
Synthesize | Show Details Find similar
21
Synthesize | Show Details Find similar
Reaxys Registry Number: 30426999
Molecular Formula: C17H13ClN4*C19H24N2
Linear Structure Formula: C17H13ClN4*C19H24N2
Molecular Weight: 589.183
InChI Key: CIGMOEILUQMEOH-UHFFFAOYSA-N
22
Synthesize | Show Details Find similar Chemical Name:
Diazepam Alprazolam
Identification
Targets
no reactions.
Druglikeness
Identification
Show Targets
1
no reactions.
Druglikeness
Identification
Show Targets
1
no reactions.
Druglikeness
Identification
Show Targets
2
no reactions.
Druglikeness
Show
2
Reaxys Registry Number: 31126453
Molecular Formula: C16H13ClN2O*C17H13ClN4
Linear Structure Formula: C16H13ClN2O*C17H13ClN4
Molecular Weight: 593.515
InChI Key: JGYXCLCOKJEZCH-UHFFFAOYSA-N
23
Synthesize | Show Details Find similar Chemical Name: morphine alprazolam Reaxys Registry Number: 29844876
Molecular Formula: C17H13ClN4*C17H19NO3
Linear Structure Formula: C17H13ClN4*C17H19NO3
Molecular Weight: 594.113
InChI Key: SRCJAZPZBUOOIY-CVTHUXBXSA-N
24
Synthesize | Show Details Find similar Chemical Name: methadone alprazolam Reaxys Registry Number: 29844909
Molecular Formula: C17H13ClN4*C21H27NO Linear Structure Formula: C17H13ClN4*C21H27NO Molecular Weight: 618.221
InChI Key: QCTNIVPLQVPJSO-UHFFFAOYSA-N
25
Synthesize | Show Details Find similar Chemical Name: alprazolam oxycodone Reaxys Registry Number: 29844878
Molecular Formula: C17H13ClN4*C18H21NO4
Linear Structure Formula: C17H13ClN4*C18H21NO4
Molecular Weight: 624.139
InChI Key: RPSVHEGMXNZZOB-RKXJKUSZSA-N
26
Synthesize | Show Details Find similar Chemical Name:
Neurol Oncol Reaxys Registry Number: 30088184
Molecular Formula: C17H13ClN4*C20H30N2O5S Linear Structure Formula: C17H13ClN4*C20H30N2O5S Molecular Weight: 719.305
InChI Key: NWPXSWGJXIJIFI-UHFFFAOYSA-N
27
Identification
Targets
Synthesize | Show Details Find similar Reaxys Registry Number: 21850151
Molecular Formula: C7H6O4*2C17H13ClN4*H2O Linear Structure Formula: C7H6O4*2C17H13ClN4*H2O Molecular Weight: 789.678
InChI Key: HMGANIIXQKIHCQ-UHFFFAOYSA-N
1 prep out of 1 reactions.
Druglikeness
Identification Physical Data (1)
Show Targets
1
Chemical Name: Alprazolam Oxazepam Diazepam
no reactions.
Druglikeness
Identification
Show Targets
1
no reactions.
Druglikeness
Identification
Show Targets
1
no reactions.
Druglikeness
Show
1
28
Synthesize | Show Details Find similar
Reaxys Registry Number: 30236661
Molecular Formula: C15H11ClN2O2*C16H13ClN2O*C17H13ClN4
Linear Structure Formula: C15H11ClN2O2*C16H13ClN2O*C17H13ClN4
Molecular Weight: 880.233
InChI Key: AHVIYPASMNHCMK-UHFFFAOYSA-N
29
Synthesize | Show Details Find similar Chemical Name: oxycodone oxymorphone alprazolam Reaxys Registry Number: 29844865
Molecular Formula: C17H13ClN4*C17H19NO4*C18H21NO4
Linear Structure Formula: C17H13ClN4*C17H19NO4*C18H21NO4
Molecular Weight: 925.481
InChI Key: SQJJBHUUGXDMEX-XGIVYFBOSA-N
30
Synthesize | Show Details Find similar Chemical Name:
Warfarin Alprazolam Verapamil Reaxys Registry Number: 31101708
Molecular Formula: C17H13ClN4*C19H16O4*C27H38N2O4
Linear Structure Formula: C17H13ClN4*C19H16O4*C27H38N2O4
Identification
Targets
Druglikeness
Identification
Show Targets
Molecular Weight: 1071.71
InChI Key: LJHBKSYDBVRTQW-UHFFFAOYSA-N
31
Synthesize | Show Details Find similar Chemical Name: Flurazepam Lorazepam Alprazolam Diazepam
no reactions.
Reaxys Registry Number: 30962639
Molecular Formula: C15H10Cl2N2O2*C16H13ClN2O*C17H13ClN4*C21H23ClFN3O Linear Structure Formula: C15H10Cl2N2O2*C16H13ClN2O*C17H13ClN4*C21H23ClFN3O Molecular Weight: 1302.56
InChI Key: VNCXCCDLSANCPP-UHFFFAOYSA-N
32
1
Synthesize | Hide Details Find similar Chemical Names and Synonyms Flurazepam Lorazepam Alprazolam Diazepam Druglikeness Lipinski rules component Molecular Weight
1302.56
logP
HBA
15
HBD
2
Matching Lipinski Rules
1
Veber rules component Polar surface Area (PSA)
173.34
Rotatable bond count
9
Matching Veber rules
1
Identification Druglikeness (1)
33
H Bond Donors
H Bond Acceptors
Rotatable Bonds
TPSA
Lipinski Number
Veber Number
2
15
9
173.34
1
1
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine 5H-dibenz(b,f)azepine-5-carboxamide Hide Details
Chemical Name: carbamazepine; alprazolam; mixture of Reaxys Registry Number: 8389905 Type of Substance: mixture (composition partially given)
no reactions.
Bioactivity
Show Targets
1
Chemical Names and Synonyms carbamazepine; alprazolam; mixture of Composition 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine
5H-dibenz(b,f)azepine-5-carboxamide
Synthesize
Synthesize
Find similar
Find similar
Bioactivity In vitro: Efficacy (1) Qualitative Information 1 of 1
34
Biological material
human
Assay Description
teratogenic Homo sapiens, human data from Israeli Teratogen Information Service; questionaring women exposed and non-exposed to title comp. during pregnancy
Results
occational cases of congenital heart disease (ventricular septal defect) were registered
Citation
Ornoy, Asher; Arnon, Judith; Shechtman, Svetlana; Moerman, Larissa; Lukashova, Irena
Reproductive Toxicology, 1998 , vol. 12, # 5 p. 511 - 515 Title/Abstract Full Text View citing articles Show Details
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine chlorimipramine N-methyl-3-(4-trifluoromethylphenyloxy)-3-(phenyl)propylamine
Chemical Name: anafranil; alprazolam; fluoxetine; mixture of
no reactions.
Reaxys Registry Number: 8389910 Type of Substance: mixture (composition partially given)
Hide Details Chemical Names and Synonyms anafranil; alprazolam; fluoxetine; mixture of Composition 8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine
chlorimipramine
N-methyl-3-(4trifluoromethylphenyloxy)-3(phenyl)propylamine
Bioactivity
Show Targets
1
Synthesize
Synthesize
Find similar
Find similar
Synthesize Find similar
Bioactivity In vitro: Efficacy (1) Qualitative Information 1 of 1
35
Biological material
human
Assay Description
teratogenic Homo sapiens, human data from Israeli Teratogen Information Service; questionaring
Results
occational cases of hydronephrosis were registered
Citation
Ornoy, Asher; Arnon, Judith; Shechtman, Svetlana; Moerman, Larissa; Lukashova, Irena
Reproductive Toxicology, 1998 , vol. 12, # 5 p. 511 - 515 Title/Abstract Full Text View citing articles Show Details
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine β-D-lactose Hypromellose 2208 Hypromellose 2910 silica gel magnesium stearate NF
Chemical Name: alprazolam; colloidal silicon dioxide; coloring additive; Hypromellose 2208; Hypromellose 2910; lactose monohydrate; magnesium stearate; mixture of
no reactions.
Reaxys Registry Number: 11346347 Type of Substance: mixture (composition partially given)
Hide Details Chemical Names and Synonyms alprazolam; colloidal silicon dioxide; coloring additive; Hypromellose 2208; Hypromellose 2910; lactose monohydrate; magnesium stearate; mixture of Composition β-D-lactose (75.54 percent)
8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a] [1,4]benzodiazepine (0.8696 percent)
silica gel (0.500 percent)
Bioactivity
Other Data (1)
Show Targets
1
Synthesize
Synthesize
Find similar
Find similar
Synthesize Find similar
magnesium stearate NF (1 percent)
Hypromellose 2208 (16.50 percent)
Hypromellose 2910 (5.501 percent)
Synthesize
Synthesize
Synthesize
Find similar
Find similar
Find similar
Bioactivity Pharmacokinetic (1) Qualitative Information 1 of 1
Assay Description
pharmacokinetics
Results
non-transformed data: Cmax (ng/ml) = 21.06, AUC0-t (ng.hr/ml) = 677.96, AUCinf (ng.hr/ml) = 711.80, Tmax (hr) = 10.32, kelim = 0.0542, t1/2 = 13.46; transformed data: Cmax (ng/ml) = 20.73, AUC0-t (ng.hr/ml) = 657.15, AUCinf (ng.hr/ml) = 686.35; figure is given
Citation
Jan, David; Cheng, Xiu Xiu; Zhang, Guohua; Carter, Roger
Patent: US2007/87055 A1, 2007 ; Title/Abstract Full Text Show Details
Other Data Use (1) Use Pattern
Reference
Extended release of alprazolam
Jan, David; Cheng, Xiu Xiu; Zhang, Guohua; Carter, Roger
Patent: US2007/87055 A1, 2007 ; Title/Abstract Full Text Show Details
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine
Chemical Name: alprazolam; 1-decyl alcohol; laurocapram; polyethylene glycol mono-oleyl ether; transcutol; mixture of
no reactions.
Bioactivity
Identification Other
Show Targets
1
36
decyl alcohol diethylene glycol monoethyl ether polyethylene glycol mono-oleyl ether Brij 96V 1-dodecylhexahydro-2H-azepin-2-one
Data (7)
Reaxys Registry Number: 11346862 Type of Substance: mixture (composition partially given)
Hide Details Chemical Names and Synonyms alprazolam; 1-decyl alcohol; laurocapram; polyethylene glycol mono-oleyl ether; transcutol; mixture of Composition 1-dodecylhexahydro-2H-azepin-2-one (5 percent)
8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine (5 percent)
Synthesize
Synthesize
Synthesize
Find similar
diethylene glycol monoethyl ether (7 percent)
decyl alcohol (7 percent)
Find similar polyethylene glycol mono-oleyl ether Brij 96V (1 percent)
Synthesize
Synthesize
Find similar
Find similar
Bioactivity In vitro: Efficacy (1) Qualitative Information 1 of 1
Assay Description
transport; induction of abdominal skin of human
Results
title substances increased alprazolam skin permeation almost 20 times; synergism observed (table is given)
Citation
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
Find similar
In vivo: Animal Model (1) Qualitative Information 1 of 1
Effect
Irritant
Assay Description
irritant albino rabbit
Citation
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
Identification Substance Label (1) Label
Reference
9
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
Other Data Use (7)
Use Pattern
Reference
psychiatric dysfunctions
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
anxiety
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
panic
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
schizophrenia
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
anxiety associated to depression
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
fertility
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
Crohn's disease
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
37
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine decyl alcohol diethylene glycol monoethyl ether 1-dodecylhexahydro-2H-azepin-2-one
Chemical Name: alprazolam; 1-decyl alcohol; laurocapram; transcutol; mixture of Reaxys Registry Number: 11347697 Type of Substance: mixture (composition partially given)
no reactions.
Bioactivity
Identification Other Data (7)
Show Targets
1
Hide Details Chemical Names and Synonyms alprazolam; 1-decyl alcohol; laurocapram; transcutol; mixture of Composition 1-dodecylhexahydro-2H-azepin-2-one (5 percent)
8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine (5 percent)
Synthesize Find similar
decyl alcohol (5 percent)
Synthesize Synthesize Find similar
diethylene glycol monoethyl ether (5 percent)
Synthesize Find similar
Bioactivity In vitro: Efficacy (1) Qualitative Information 1 of 1
Assay Description
transport; induction of abdominal skin of human
Results
title substances increased alprazolam skin permeation 6.6 times; synergism observed (table is given)
Citation
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
In vivo: Animal Model (1)
Find similar
Qualitative Information 1 of 1
Effect
Irritant
Assay Description
irritant albino rabbit
Citation
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
Identification Substance Label (1) Label
Reference
6
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
Other Data Use (7)
Use Pattern
Reference
psychiatric dysfunctions
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
anxiety
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
panic
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
schizophrenia
Title/Abstract Full Text Show Details
anxiety associated to depression
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
fertility
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
Crohn's disease
Title/Abstract Full Text Show Details
38
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine decyl alcohol polyethylene glycol mono-oleyl ether Brij 96V Hide Details Chemical Names and Synonyms
Chemical Name: alprazolam; 1-decyl alcohol; polyethylene glycol mono-oleyl ether; mixture of Reaxys Registry Number: 11348258 Type of Substance: mixture (composition partially given)
no reactions.
Bioactivity
Identification Other Data (7)
Show Targets
1
alprazolam; 1-decyl alcohol; polyethylene glycol mono-oleyl ether; mixture of Composition 8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine (5 percent)
decyl alcohol (7 percent)
polyethylene glycol mono-oleyl ether Brij 96V (1 percent)
Synthesize Find similar
Synthesize Find similar
Bioactivity In vitro: Efficacy (1) Qualitative Information 1 of 1
Assay Description
transport; induction of abdominal skin of human
Results
title substances increased alprazolam skin permeation almost 10.7 times; synergism observed (table is given)
Citation
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
Identification Substance Label (1) Label
Reference
8
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
Other Data Use (7)
Use Pattern
Reference
psychiatric dysfunctions
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
anxiety
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
panic
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
Synthesize Find similar
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
schizophrenia
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
anxiety associated to depression
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
fertility
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
Crohn's disease
Title/Abstract Full Text Show Details
39
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine decyl alcohol 1-dodecylhexahydro-2H-azepin-2-one
Chemical Name: alprazolam; 1-decyl alcohol; laurocapram; mixture of
no reactions.
Reaxys Registry Number: 11348428 Type of Substance: mixture (composition partially given)
Hide Details Chemical Names and Synonyms alprazolam; 1-decyl alcohol; laurocapram; mixture of Composition 1-dodecylhexahydro-2H-azepin-2-one (5 percent)
8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine (5 percent)
Synthesize Find similar
decyl alcohol (5 percent)
Synthesize Synthesize Find similar
Bioactivity In vitro: Efficacy (1) Qualitative Information 1 of 1
Assay Description
transport; induction of abdominal skin of human
Results
title substances increased alprazolam skin permeation 2.4 times; synergism observed (table is given)
Citation
LABORATORIO REIG JOFRE, S.A.
Find similar
Bioactivity
Identification Other Data (7)
Show Targets
1
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
Identification Substance Label (1) Label
Reference
5
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
Other Data Use (7)
Use Pattern
Reference
psychiatric dysfunctions
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
anxiety
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
panic
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
schizophrenia
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
anxiety associated to depression
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
fertility
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
Crohn's disease
Title/Abstract Full Text Show Details
40
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine diethylene glycol monoethyl ether 1-dodecylhexahydro-2H-azepin-2-one
Chemical Name: alprazolam; laurocapram; transcutol; mixture of Reaxys Registry Number: 11348429 Type of Substance: mixture (composition partially given)
no reactions.
Bioactivity
Identification Other Data (7)
Hide Details Chemical Names and Synonyms alprazolam; laurocapram; transcutol; mixture of Composition 1-dodecylhexahydro-2H-azepin-2-one (5 percent)
8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine (5 percent)
diethylene glycol monoethyl ether (5 percent)
Show Targets
1
Synthesize
Synthesize
Find similar
Find similar
Bioactivity In vitro: Efficacy (1) Qualitative Information 1 of 1
Assay Description
transport; induction of abdominal skin of human
Results
title substances increased alprazolam skin permeation 2.9 times; synergism observed (table is given)
Citation
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
Identification Substance Label (1) Label
Reference
4
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
Other Data Use (7)
Use Pattern
Reference
psychiatric dysfunctions
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
anxiety
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
panic
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
schizophrenia
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
Synthesize Find similar
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
anxiety associated to depression
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
fertility
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
Crohn's disease
Title/Abstract Full Text Show Details
41
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine polyethylene glycol mono-oleyl ether Brij 96V Hide Details
Chemical Name: alprazolam; polyethylene glycol mono-oleyl ether; mixture of
no reactions.
Reaxys Registry Number: 11349344 Type of Substance: mixture (composition partially given)
Identification Other Data (7)
Chemical Names and Synonyms alprazolam; polyethylene glycol mono-oleyl ether; mixture of Composition 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine (5 percent)
polyethylene glycol mono-oleyl ether Brij 96V (1 percent)
Synthesize
Synthesize
Find similar
Find similar
Identification Substance Label (1) Label
Reference
7
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
Other Data Use (7)
Use Pattern
Reference
psychiatric dysfunctions
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
anxiety
LABORATORIO REIG JOFRE, S.A.
Show Targets
1
Patent: WO2006/32624 A1, 2006 ;
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
panic
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
schizophrenia
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
anxiety associated to depression
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
fertility
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
Crohn's disease
Title/Abstract Full Text Show Details
42
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine decyl alcohol Hide Details
Chemical Name: alprazolam; 1-decyl alcohol; mixture of
no reactions.
Reaxys Registry Number: 11350032 Type of Substance: mixture (composition partially given)
Chemical Names and Synonyms alprazolam; 1-decyl alcohol; mixture of Composition 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine (5 percent)
Synthesize Find similar
Identification Substance Label (1) Label
Reference
3
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
decyl alcohol (5 percent)
Synthesize Find similar
Identification Other Data (7)
Show Targets
1
Other Data Use (7) Use Pattern
Reference
psychiatric dysfunctions
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
anxiety
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
panic
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
schizophrenia
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
anxiety associated to depression
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
fertility
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
Crohn's disease
Title/Abstract Full Text Show Details
43
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine 1-dodecylhexahydro-2H-azepin-2-one Hide Details
Chemical Name: alprazolam; laurocapram; mixture of
no reactions.
Reaxys Registry Number: 11350033 Type of Substance: mixture (composition partially given)
Chemical Names and Synonyms alprazolam; laurocapram; mixture of Composition 1-dodecylhexahydro-2H-azepin-2-one (5 percent)
Synthesize Find similar
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine (5 percent)
Synthesize
Identification Other Data (7)
Show Targets
1
Find similar
Identification Substance Label (1) Label
Reference
1
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
Other Data Use (7)
Use Pattern
Reference
psychiatric dysfunctions
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
anxiety
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
panic
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
schizophrenia
Title/Abstract Full Text Show Details
anxiety associated to depression
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
fertility
Title/Abstract Full Text Show Details
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ;
Crohn's disease
Title/Abstract Full Text Show Details
44
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine diethylene glycol monoethyl ether Hide Details
Chemical Name: alprazolam; transcutol; mixture of
no reactions.
Reaxys Registry Number: 11350034 Type of Substance: mixture (composition partially given)
Chemical Names and Synonyms alprazolam; transcutol; mixture of Composition 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine (5 percent)
diethylene glycol monoethyl ether (5 percent)
Identification Other Data (7)
Show Targets
1
Synthesize
Synthesize
Find similar
Find similar
Identification Substance Label (1) Label
Reference
2
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
Other Data Use (7)
Use Pattern
Reference
psychiatric dysfunctions
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
anxiety
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
panic
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
schizophrenia
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
anxiety associated to depression
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
fertility
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
Crohn's disease
LABORATORIO REIG JOFRE, S.A.
Patent: WO2006/32624 A1, 2006 ; Title/Abstract Full Text Show Details
mixture (composition completely given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a]
Reaxys Registry Number: 11364449 Type of Substance: mixture (composition completely given)
no reactions.
Bioactivity
Show Targets
1
45
[1,4]benzodiazepine N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2a]pyridine-3-yl]acetamide 1-(aminomethyl)-1-cyclohexaneacetic acid 4-hydroxybutyric acid sodium salt
Hide Details
Composition 8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine (2 mg)
1-(aminomethyl)-1-cyclohexaneacetic acid (200 mg)
Synthesize
Synthesize
Find similar
Find similar
4-hydroxybutyric acid sodium salt (7 g)
Synthesize Find similar
N,N-dimethyl-2-[6-methyl-2-(4methylphenyl)imidazo[1,2-a]pyridine-3yl]acetamide (10 mg)
Synthesize Find similar
Bioactivity In vitro: Efficacy (1) Qualitative Information 1 of 1
Biological material
human
Assay Description
patient with ARG; effect on human
Results
The patient had markedly decreased fatigue and little to no toxicity. 7 grams NaGHB as a single dose is a large dose, which may be too toxic for some patients.
Citation
JOHNSON, Joseph
Patent: WO2006/124609 A2, 2006 ; Title/Abstract Full Text Show Details
46
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2a]pyridine-3-yl]acetamide 1-(aminomethyl)-1-cyclohexaneacetic acid 4-hydroxybutyric acid sodium salt
Reaxys Registry Number: 11364450 Type of Substance: mixture (composition partially given)
no reactions.
Bioactivity
Show Targets
Hide Details
Composition 8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine (2 mg)
1-(aminomethyl)-1-cyclohexaneacetic acid (200 mg)
Synthesize
Synthesize
Find similar
Find similar
4-hydroxybutyric acid sodium salt
Synthesize Find similar
N,N-dimethyl-2-[6-methyl-2-(4methylphenyl)imidazo[1,2-a]pyridine-3yl]acetamide (10 mg)
Synthesize Find similar
Bioactivity In vitro: Efficacy (1) Qualitative Information 1 of 1
Biological material
human
Assay Description
patient with ARG; effect on human
Results
Within one week of beginning to take the GHB, the patient had marked decrease in appetite. At a dose of 3 grams prior to sleep and a second dose upon awakening, the patient was eating only one to two small meals per day. His maximum previous weight had been 169 lbs and his baseline weight was 159
1
pounds. He lost weight down to 145 lbs and looked gaunt Citation
47
JOHNSON, Joseph
Patent: WO2006/124609 A2, 2006 ; Title/Abstract Full Text Show Details
mixture (composition completely given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine 1-(aminomethyl)-1-cyclohexaneacetic acid N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2a]pyridine-3-yl]acetamide
Reaxys Registry Number: 11364457 Type of Substance: mixture (composition completely given)
no reactions.
Bioactivity
Show Targets
1
Hide Details
Composition 8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine (7 mg)
1-(aminomethyl)-1-cyclohexaneacetic acid (300 mg)
Synthesize
Synthesize
Find similar
Find similar
N,N-dimethyl-2-[6-methyl-2-(4methylphenyl)imidazo[1,2-a]pyridine-3yl]acetamide (10 mg)
Synthesize Find similar
Bioactivity In vitro: Efficacy (1) Qualitative Information 1 of 1
48
Biological material
human
Assay Description
patient with ARG; effect on human
Results
The patient had next day sedation due to the high dose of alprazolam. However, after the effects of the alprazolam had dissipated, the patient had markedly decreased fatigue. Such high doses of alprazolam are acceptable but often lead to next day sedation. The dose of alprazolam may be reduced by adding a Class I or II agent to the regimen. The patient had markedly decreased fatigue and increased motivation on this regimen.GABAnergic agents during waking hours provide partial relief of fatigue
Citation
JOHNSON, Joseph
Patent: WO2006/124609 A2, 2006 ; Title/Abstract Full Text Show Details
mixture (composition completely given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2a]pyridine-3-yl]acetamide 1-(aminomethyl)-1-cyclohexaneacetic acid 4-hydroxybutyric acid sodium salt
Reaxys Registry Number: 11364464 Type of Substance: mixture (composition completely given)
no reactions.
Bioactivity
Show Targets
1
Hide Details
Composition 8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine (3 mg)
1-(aminomethyl)-1-cyclohexaneacetic acid (300 mg)
Synthesize
Synthesize
Find similar
Find similar
4-hydroxybutyric acid sodium salt (5.25 g)
Synthesize Find similar
N,N-dimethyl-2-[6-methyl-2-(4methylphenyl)imidazo[1,2-a]pyridine-3yl]acetamide (10 mg)
Synthesize Find similar
Bioactivity In vitro: Efficacy (1) Qualitative Information 1 of 1
Biological material
human
Assay Description
patient with ARG; effect on human
Results
Mixture had marked reduction in fatigue and markedly increased motivation on these regimens. On a scale from 0 to 10 where 10 is the most tired, the patient rated the fatigue at 10 without treatment, 3 to 4 with treatment on multiple GABAnergic agents
Citation
JOHNSON, Joseph
Patent: WO2006/124609 A2, 2006 ; Title/Abstract Full Text Show Details
mixture (composition completely given) :
Reaxys Registry Number: 11364465
no reactions.
Bioactivity
Show
1
49
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine 1-(aminomethyl)-1-cyclohexaneacetic acid N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2a]pyridine-3-yl]acetamide 4-hydroxybutyric acid sodium salt
Type of Substance: mixture (composition completely given)
Targets
Hide Details
Composition 8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine (3 mg)
1-(aminomethyl)-1-cyclohexaneacetic acid (300 mg)
Synthesize
Synthesize
Find similar
Find similar
4-hydroxybutyric acid sodium salt (9 g)
Synthesize Find similar
N,N-dimethyl-2-[6-methyl-2-(4methylphenyl)imidazo[1,2-a]pyridine-3yl]acetamide (10 mg)
Synthesize Find similar
Bioactivity In vitro: Efficacy (1) Qualitative Information 1 of 1
Biological material
human
Assay Description
patient with ARG; effect on human
Results
The patient had markedly decreased fatigue despite the interruption of sleep by vomiting. The combination of red wine and such large doses of GHB are not typically recommended by the inventor and can be fatal
Citation
JOHNSON, Joseph
Patent: WO2006/124609 A2, 2006 ;
Title/Abstract Full Text Show Details
50
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine Eudragit E-100 magnesium stearate NF Hide Details
Show Related Substances
Chemical Name: alprazolam; Eudragit E-100; magnesium stearate; SDA-3A; sugar spheres; mixture of
no reactions.
Show Targets
Bioactivity
Show Targets
1
Reaxys Registry Number: 11365175 Type of Substance: mixture (composition partially given)
Chemical Names and Synonyms alprazolam; Eudragit E-100; magnesium stearate; SDA-3A; sugar spheres; mixture of Composition 8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine (5.141 kg)
Synthesize
magnesium stearate NF (11.714 kg)
Eudragit E-100 (40.4 kg)
Synthesize
Synthesize
Find similar
Find similar
Find similar
51
mixture (composition completely given) :
1-monolauroyl-rac-glycerol dodecan-1-ol acetate 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine EVA 40
Reaxys Registry Number: 11366243 Type of Substance: mixture (composition completely given)
no reactions.
Hide Details
Composition 8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine (15 weight percent)
1-monolauroyl-rac-glycerol (13 - 20 weight percent)
Synthesize
dodecan-1-ol acetate (12 - 27 weight percent)
Synthesize
Synthesize
Find similar
Find similar
Find similar
EVA 40 (45 - 53 weight percent)
Synthesize Find similar
Bioactivity In vitro: Efficacy (2) Qualitative Information 1 of 2
2 of 2
52
Assay Description
transdermal flux; effect on epidermis of human
Results
superior flux of alprazolam through the skin of up to three times that of a GML/lauryl lactate mixture was achieved; quickest steady state flux was reached at 15/25 w of GML/lauryl acetate; figure is given
Citation
ALZA CORPORATION
Patent: EP835136 B1, 2006 ; Title/Abstract Full Text Show Details
Assay Description
transdermal flux; effect on epidermis of human
Results
achieved the greatest flux of alprazolam through skin at 20/12 w of GML/lauryl acetate; figure is given
Citation
ALZA CORPORATION
Patent: EP835136 B1, 2006 ; Title/Abstract Full Text Show Details
mixture (composition completely given) :
glycerol monooleate n-tetradecyl lactate 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine EVA 40
Reaxys Registry Number: 11366301 Type of Substance: mixture (composition completely given)
no reactions.
Hide Details
Composition 8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine (15 weight percent)
n-tetradecyl lactate (12 weight percent)
EVA 40 (53 weight percent)
Bioactivity
Show Targets
1
Synthesize
Synthesize
Synthesize
Find similar
Find similar
Find similar glycerol monooleate (20 weight percent)
Synthesize Find similar
Bioactivity In vitro: Efficacy (1) Qualitative Information 1 of 1
53
Assay Description
transdermal flux; effect on epidermis of human
Results
figure is given
Citation
ALZA CORPORATION
Patent: EP835136 B1, 2006 ; Title/Abstract Full Text Show Details
mixture (composition partially given) :
1-monolauroyl-rac-glycerol 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine EVA 40 Hide Details
Chemical Name: alprazolam; EVA 40; glycerol monolaurate; lauryl lactate; mixture of Reaxys Registry Number: 11366454 Type of Substance: mixture (composition partially given)
Chemical Names and Synonyms alprazolam; EVA 40; glycerol monolaurate; lauryl lactate; mixture of Composition
no reactions.
Bioactivity
Show Targets
1
8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine (15 weight percent)
1-monolauroyl-rac-glycerol (13 - 20 weight percent)
Synthesize
Synthesize
Find similar
Find similar
EVA 40 (45 - 53 weight percent)
Synthesize Find similar
Bioactivity In vitro: Efficacy (2) Qualitative Information 1 of 2
2 of 2
54
Assay Description
transdermal flux; effect on epidermis of human
Results
figure is given
Citation
ALZA CORPORATION
Patent: EP835136 B1, 2006 ; Title/Abstract Full Text Show Details
Assay Description
transdermal flux; effect on epidermis of human
Results
figure is given
Citation
ALZA CORPORATION
Patent: EP835136 B1, 2006 ; Title/Abstract Full Text Show Details
mixture (composition partially given) :
glycerol monooleate 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine EVA 40 Hide Details
Chemical Name: alprazolam; EVA 40; glycerol monooleate; lauryl lactate; mixture of
no reactions.
Bioactivity
Reaxys Registry Number: 11366937 Type of Substance: mixture (composition partially given)
Chemical Names and Synonyms alprazolam; EVA 40; glycerol monooleate; lauryl lactate; mixture of Composition 8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine (15 weight percent)
EVA 40 (53 weight percent)
glycerol monooleate (20 weight percent)
Show Targets
1
Synthesize
Synthesize
Synthesize
Find similar
Find similar
Find similar
Bioactivity In vitro: Efficacy (1) Qualitative Information 1 of 1
55
Assay Description
transdermal flux; effect on epidermis of human
Results
figure is given
Citation
ALZA CORPORATION
Patent: EP835136 B1, 2006 ; Title/Abstract Full Text Show Details
mixture (composition completely given) :
glycerol monooleate 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine EVA 40
Reaxys Registry Number: 11366970 Type of Substance: mixture (composition completely given)
no reactions.
Bioactivity
Hide Details
Composition 8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine (15 weight percent)
Synthesize Find similar
EVA 40 (55 weight percent)
glycerol monooleate (30 weight percent)
Synthesize
Synthesize
Find similar
Find similar
Show Targets
1
Bioactivity In vitro: Efficacy (1) Qualitative Information 1 of 1
56
Assay Description
transdermal flux; effect on epidermis of human
Results
figure is given
Citation
ALZA CORPORATION
Patent: EP835136 B1, 2006 ; Title/Abstract Full Text Show Details
mixture (composition completely given) :
γ-hydroxybutyric acid 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine 1-(aminomethyl)-1-cyclohexaneacetic acid
Reaxys Registry Number: 11371005 Type of Substance: mixture (composition completely given)
no reactions.
Bioactivity
Show Targets
1
Show
1
Hide Details
Composition 8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine (2 mg)
γ-hydroxybutyric acid (5.25 g)
Synthesize
Synthesize
Find similar
Find similar
1-(aminomethyl)-1-cyclohexaneacetic acid (200 mg)
Synthesize Find similar
Bioactivity In vitro: Efficacy (1) Qualitative Information 1 of 1
Biological material
human
Assay Description
patient with ARG; effect on human
Results
The patient experienced markedly more restful sleep, markedly decreased fatigue, and increased motivation on this regimen.
Citation
JOHNSON, Joseph
Patent: WO2006/124609 A2, 2006 ; Title/Abstract Full Text Show Details
mixture (composition partially given) :
Chemical Name:
no reactions.
Bioactivity
57
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine Hide Details
alprazolam; phosphate buffered saline; mixture of
Targets
Bioactivity
Show Targets
Reaxys Registry Number: 11374356 Type of Substance: mixture (composition partially given)
Chemical Names and Synonyms alprazolam; phosphate buffered saline; mixture of Composition 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
Synthesize Find similar
Bioactivity Metabolism (1) Qualitative Information 1 of 1
58
Assay Description
transport skin epidermis of hairless mouse
Results
treatment with title mixture at 37 C resulted to steady-state flux of alprazolam (skin flux) of 0.1 μg/cm2/h
Citation
Warner, Kevin S.; Zhang, Jie
Patent: US2005/266085 A1, 2005 ; Title/Abstract Full Text Show Details
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine 2-methoxy-4-(2-propenyl)-phenol
Reaxys Registry Number: 11385201 Type of Substance: mixture (composition partially given)
no reactions.
Hide Details
Composition 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine
2-methoxy-4-(2-propenyl)-phenol
1
Synthesize
Synthesize
Find similar
Find similar
Bioactivity Metabolism (1) Qualitative Information 1 of 1
59
Assay Description
transport skin epidermis of hairless mouse
Results
treatment with title mixture at 37 C resulted to steady-state flux of alprazolam (skin flux) of 4 μg/cm2/h
Citation
Warner, Kevin S.; Zhang, Jie
Patent: US2005/266085 A1, 2005 ; Title/Abstract Full Text Show Details
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine cis-1-acetyl-4-[4-{[2-(2,4-dichloro-phenyl)-2-(1H-imidazol-1ylmethyl)1-1,3-dioxo-lan-4-yl]methoxyl}-phenyl]piperazine
Reaxys Registry Number: 11387320 Type of Substance: mixture (composition partially given)
no reactions.
Bioactivity
Hide Details
Composition 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine
Bioactivity
cis-1-acetyl-4-[4-{[2-(2,4-dichloro-phenyl)-2-(1H-imidazol-1ylmethyl)1-1,3-dioxo-lan-4-yl]methoxyl}-phenyl]piperazine
Synthesize
Synthesize
Find similar
Find similar
Show Targets
1
In vitro: Efficacy (1) Qualitative Information 1 of 1
60
Biological material
Wistar rat
Assay Description
cocaine self-administration; effect on Wistar rat
Results
title compound administration reduced cocaine self-administration without affecting food-maintained responding at all tested doses of cocaine; synergistic effect was observed; figures are given
Citation
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY and AGRICULTURAL and MECHANICAL COLLEGE
Patent: WO2007/56618 A1, 2007 ; Title/Abstract Full Text Show Details
mixture (composition partially given) :
2-methyl-1,2-di(pyridin-3-yl)-1-propanone 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine
Reaxys Registry Number: 11387321 Type of Substance: mixture (composition partially given)
no reactions.
Bioactivity
Show Targets
Hide Details
Composition 2-methyl-1,2-di(pyridin-3-yl)-1-propanone
Synthesize Find similar
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine
Synthesize Find similar
Bioactivity In vitro: Efficacy (1) Qualitative Information 1 of 1
Biological material
Wistar rat
Assay Description
cocaine self-administration; effect on Wistar rat
Results
title compound administration reduced cocaine self-administration without affecting food-maintained responding; synergistic effect was observed; figure is given
Citation
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY and AGRICULTURAL and MECHANICAL COLLEGE
Patent: WO2007/56618 A1, 2007 ; Title/Abstract Full Text Show Details
1
61
Reaxys Registry Number: 11387322 Type of Substance: mixture (composition partially given)
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine poly ethylene glycol 400
no reactions.
Bioactivity
Show Targets
1
Show Targets
Hide Details
Composition 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine
poly ethylene glycol 400
Synthesize
Synthesize
Find similar
Find similar
Bioactivity Metabolism (1) Qualitative Information 1 of 1
Assay Description
transport skin epidermis of hairless mouse
Results
treatment with title mixture at 37 C resulted to steady-state flux of alprazolam (skin flux) of 0.2 μg/cm2/h
Citation
Warner, Kevin S.; Zhang, Jie
Patent: US2005/266085 A1, 2005 ; Title/Abstract Full Text Show Details
mixture (composition partially given) :
62
TR-2 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine
Reaxys Registry Number: 11396535 Type of Substance: mixture (composition partially given)
Hide Details
Show Related Substances
Composition 8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine
TR-2 (0.4 weight percent)
no reactions.
Synthesize
Synthesize
Find similar
Find similar
mixture (composition partially given) :
63
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine
Reaxys Registry Number: 11400561 Type of Substance: mixture (composition partially given)
no reactions.
Hide Details
Composition 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine
Synthesize Find similar
Bioactivity Metabolism (1) Qualitative Information 1 of 1
Identification
Assay Description
transport skin epidermis of hairless mouse
Results
treatment with title mixture at 37 C resulted to steady-state flux of alprazolam (skin flux) of 3 μg/cm2/h
Citation
Warner, Kevin S.; Zhang, Jie
Patent: US2005/266085 A1, 2005 ; Title/Abstract Full Text Show Details
Bioactivity
Identification
Show Targets
1
Substance Label (1) Label
Reference
6
Warner, Kevin S.; Zhang, Jie
Patent: US2005/266085 A1, 2005 ; Title/Abstract Full Text Show Details
64
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine ethanol; phosphate buffered saline; mixture of
Reaxys Registry Number: 11400562 Type of Substance: mixture (composition partially given)
no reactions.
Bioactivity
Show Targets
1
Bioactivity
Identification
Show Targets
1
Hide Details
Composition 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine
ethanol; phosphate buffered saline; mixture of
Synthesize Find similar
Bioactivity Metabolism (1) Qualitative Information 1 of 1
Assay Description
transport skin epidermis of hairless mouse
Results
treatment with title mixture at 37 C resulted to steady-state flux of alprazolam (skin flux) of 1.0-4 μg/cm2/h
Citation
Warner, Kevin S.; Zhang, Jie
Patent: US2005/266085 A1, 2005 ; Title/Abstract Full Text Show Details
mixture (composition partially given) :
65
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine
Reaxys Registry Number: 11400563 Type of Substance: mixture (composition partially given)
Hide Details
Composition 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine
no reactions.
Synthesize Find similar
Bioactivity Metabolism (1) Qualitative Information 1 of 1
Assay Description
transport skin epidermis of hairless mouse
Results
treatment with title mixture at 37 C resulted to steady-state flux of alprazolam (skin flux) of 0.3-1.1 μg/cm2/h
Citation
Warner, Kevin S.; Zhang, Jie
Patent: US2005/266085 A1, 2005 ; Title/Abstract Full Text Show Details
Identification Substance Label (1) Label
Reference
4; 5
Warner, Kevin S.; Zhang, Jie
Patent: US2005/266085 A1, 2005 ; Title/Abstract Full Text Show Details
mixture (composition partially given) :
66
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine
Reaxys Registry Number: 11400564 Type of Substance: mixture (composition partially given)
Hide Details
Show Related Substances
Composition 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine
no reactions.
Show Targets
Synthesize Find similar
67
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine
Reaxys Registry Number: 11402446 Type of Substance: mixture (composition partially given)
no reactions.
Bioactivity
Show Targets
1
Physical Data (1)
Show Targets
1
Hide Details
Composition 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine
Synthesize Find similar
Bioactivity Metabolism (1) Qualitative Information 1 of 1
Assay Description
transport skin epidermis of hairless mouse
Results
treatment with title mixture at 37 C resulted to steady-state flux of alprazolam (skin flux) of 3 μg/cm2/h
Citation
Warner, Kevin S.; Zhang, Jie
Patent: US2005/266085 A1, 2005 ; Title/Abstract Full Text Show Details
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a]
Reaxys Registry Number: 18355101 Type of Substance: mixture (composition partially given)
no reactions.
68
[1,4]benzodiazepine Carbopolreg; 980 ethanol water Hide Details
Composition ethanol (49 weight percent)
8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine (1 weight percent)
Synthesize
water
Synthesize
Synthesize
Find similar
Find similar
Find similar Carbopolreg; 980 (1 weight percent)
Synthesize Find similar
Physical Data Dynamic Viscosity (1) Kind of measurement (Dynamic Viscosity)
Dynamic Viscosity
Reference
BROOKFIELD RV-DVII+
6.5 P
CARRARA, Dario Norberto; Grenier, Arnaud; Decaudin, Celine; Rogue, Christelle; Alberti, Ingo; Delpy, Laetitia
Patent: US2008/138391 A1, 2008 ; Title/Abstract Full Text Show Details
69
mixture (composition partially given) :
anhydrous 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6chloro-1,3-dihydro-2H-indol-2-one 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4benzodiazepin-2-one 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine Hide Details
Reaxys Registry Number: 21174023 Type of Substance: mixture (composition partially given)
no reactions.
Bioactivity
Show Targets
1
Composition 7-chloro-5-(2-chlorophenyl)-3-hydroxy1,3-dihydro-2H-1,4-benzodiazepin-2-one
8-chloro-1-methyl-6-phenyl-4H-striazolo[4,3-a][1,4]benzodiazepine
Synthesize
Synthesize
Find similar
Find similar
anhydrous 5-(2-(4-(1,2-benzisothiazol-3yl)-1-piperazinyl)ethyl)-6-chloro-1,3dihydro-2H-indol-2-one
Synthesize Find similar
Bioactivity In vitro: Efficacy (1) Qualitative Information 1 of 1
70
Assay Description
side effects; induction of human having senile dementia with depression and psychotic features
Citation
Medcara, L.L.C.
Patent: US7863277 B1, 2011 ; Title/Abstract Full Text Show Details
mixture (composition partially given) :
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine Ceftriaxone
Reaxys Registry Number: 27597244 Type of Substance: mixture (composition partially given)
no reactions.
Hide Details
Composition 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine
Synthesize Find similar
Ceftriaxone
Synthesize Find similar
Show Targets
1