Diphenyl(2-piperidinyl)methanol (Pipradrol)

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HO

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11 reactions in Reaxys

2017-08-08 14h:57m:48s (EST)

HN

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N+ HO

Br–

HO HN

Rx-ID: 40225685 View in Reaxys 1/11 Yield

Conditions & References

72 %

With formic acid, C29H32ClIrNO, sodium formate in water, Time= 36h, pH= 4.5, Reflux Talwar, Dinesh; Li, Ho Yin; Durham, Emma; Xiao, Jianliang; Chemistry - A European Journal; vol. 21; nb. 14; (2015); p. 5370 - 5379 View in Reaxys

H N

H

H N

H OH

O Br Mg

O

Rx-ID: 29903968 View in Reaxys 2/11 Yield

Conditions & References

73 %

Stage 1: in tetrahydrofuran, T= 0 - 23 °C , Inert atmosphere Stage 2: With water, ammonium chloride in tetrahydrofuran, diethyl ether Alvarez-Ibarra, Carlos; Lujan, Juan F. Collados; Quiroga-Feijoo, Maria L.; Tetrahedron Asymmetry; vol. 21; nb. 19; (2010); p. 2334 - 2345 View in Reaxys

H N

H

H N

H OH

O Cl

H

Br–+Mg

O

Rx-ID: 2321053 View in Reaxys 3/11 Yield

Conditions & References Rao, A. V. Rama; Gurjar, M. K.; Sharma, P. A.; Kaiwar, Vijay; Tetrahedron Letters; vol. 31; nb. 16; (1990); p. 2341 - 2344 View in Reaxys

H N

H

H N

H OH

O Cl

H

Br–+Mg

O

Rx-ID: 2321057 View in Reaxys 4/11 Yield

Conditions & References Rao, A. V. Rama; Gurjar, M. K.; Sharma, P. A.; Kaiwar, Vijay; Tetrahedron Letters; vol. 31; nb. 16; (1990); p. 2341 - 2344 View in Reaxys

Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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H N

O N

H OH

OH

Rx-ID: 21816317 View in Reaxys 5/11 Yield

Conditions & References Reaction Steps: 3 1: H2 2: HCl With hydrogenchloride, hydrogen Rao, A. V. Rama; Gurjar, M. K.; Sharma, P. A.; Kaiwar, Vijay; Tetrahedron Letters; vol. 31; nb. 16; (1990); p. 2341 - 2344 View in Reaxys

H N

O N

H OH

OH

Rx-ID: 21816318 View in Reaxys 6/11 Yield

Conditions & References Reaction Steps: 3 1: H2 2: HCl With hydrogenchloride, hydrogen Rao, A. V. Rama; Gurjar, M. K.; Sharma, P. A.; Kaiwar, Vijay; Tetrahedron Letters; vol. 31; nb. 16; (1990); p. 2341 - 2344 View in Reaxys

H N

H N

O

H OH

OH

Rx-ID: 21855768 View in Reaxys 7/11 Yield

Conditions & References Reaction Steps: 2 1: HCl With hydrogenchloride Rao, A. V. Rama; Gurjar, M. K.; Sharma, P. A.; Kaiwar, Vijay; Tetrahedron Letters; vol. 31; nb. 16; (1990); p. 2341 - 2344 View in Reaxys

H N

H N

O

H OH

OH

Rx-ID: 21855769 View in Reaxys 8/11 Yield

Conditions & References Reaction Steps: 2 1: HCl

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With hydrogenchloride Rao, A. V. Rama; Gurjar, M. K.; Sharma, P. A.; Kaiwar, Vijay; Tetrahedron Letters; vol. 31; nb. 16; (1990); p. 2341 - 2344 View in Reaxys

HO HN

Rx-ID: 5502279 View in Reaxys 9/11 Yield

Conditions & References N-Acetyl-Deriv. (II), KOH, in Butan-1-ol Ogata; Kano; Chemistry and Industry (London, United Kingdom); (1967); p. 321 View in Reaxys ueberschuess. Phenylmagnesiumbromid in Ae. 1. Pipecolinsaeureethylester in Anisol, unter N2, Siedetemp, 12 h 2. Eis 3. wss. HCl Winterfeld; Rath; Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft; vol. 293; (1960); p. 141,146 View in Reaxys ueberschuess. Phenylmagnesiumbromid in Ae. 1. trans-Dioxo-chinanthridin in Anisol, unter N2, Siedetemp, 12 h 2. Eis 3. wss. HCl Winterfeld; Rath; Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft; vol. 293; (1960); p. 141,146 View in Reaxys ueberschuess. Phenylmagnesiumbromid in Ae. 1. cis-Dioxo-chinanthridin in Anisol, unter N2, Siedetemp, 12 h 2. Eis 3. wss. HCl Winterfeld; Rath; Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft; vol. 293; (1960); p. 141,146 View in Reaxys Piperidin (15i), HCl Seebach,D. et al.; Chemische Berichte; vol. 110; (1977); p. 1852 - 1865 View in Reaxys

Cl

HO

H

HN

Rx-ID: 8348922 View in Reaxys 10/11 Yield

Conditions & References N-Acetylpiperidin-Verb. (9) 1. caustic Kali, in 1-Butanol, 140grad 2. H2O, Alkohol, HCl Ogata et al.; Kogyo Kagaku Zasshi; vol. 72; (1969); p. 195,197,198; ; vol. 70; nb. 96566; (1969) View in Reaxys entspr. Ethoxycarbonyl-Verb. (11) 1. caustic Kali, in n-Butanol, Δ 2. H2O, HCl, Me Ogata et al.; Kogyo Kagaku Zasshi; vol. 72; (1969); p. 195,197,198; ; vol. 70; nb. 96566; (1969) View in Reaxys entspr. Benzylverb. (13), HCl, A., Platinoxid in A., normal Temp., normal Druck

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Ogata et al.; Kogyo Kagaku Zasshi; vol. 72; (1969); p. 195,197,198; ; vol. 70; nb. 96566; (1969) View in Reaxys

diphenyl-<2>pyridyl-methanol hydrochloride

HO HN

Rx-ID: 5502280 View in Reaxys 11/11 Yield

Conditions & References With ethanol, platinum, T= 70 - 80 °C , Hydrogenation Tilford et al.; Journal of the American Chemical Society; vol. 70; (1948); p. 4001,4005 View in Reaxys

Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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