1,3-Benzodioxol-5-ol (Sesamol) by Asch

Query Query HO

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1 substances in Reaxys

2017-10-14 23h:08m:31s (EST)

1. Query O

Search as: As drawn, No salts, No mixtures, No isotopes, No charges, No radicals

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Reaxys ID 127405 View in Reaxys

1/1 CAS Registry Number: 533-31-3 Chemical Name: Sesamol; benzo[1,3]dioxol-5-ol; Benzo[1,3]dioxol-5-ol Linear Structure Formula: C7H5O2OH Molecular Formula: C7H6O3 Molecular Weight: 138.123 Type of Substance: heterocyclic InChI Key: LUSZGTFNYDARNI-UHFFFAOYSA-N Note:

O O

Substance Label (103) Label References 14

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14i

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seasmol

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7ao

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18-OH

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1r; 1f

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14d

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"21" for 40

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BZX

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2017-10-14 23:10:10

2; 2a

Bai, Sha; Liao, Yuting; Lin, Lili; Luo, Weiwei; Liu, Xiaohua; Feng, Xiaoming; Journal of Organic Chemistry; vol. 79; nb. 21; (2014); p. 10662 - 10668, View in Reaxys

Lavecchia, Antonio; Di Giovanni, Carmen; Cerchia, Carmen; Russo, Annapina; Russo, Giulia; Novellino, Ettore; Journal of Medicinal Chemistry; vol. 56; nb. 7; (2013); p. 2861 - 2873, View in Reaxys

Kumar, Tarun; Mobin, Shaikh M.; Namboothiri, Irishi N.N.; Tetrahedron; vol. 69; nb. 24; (2013); p. 4964 4972, View in Reaxys

Tripathi, Laxmi; Kumar, Praveen; European Journal of Medicinal Chemistry; vol. 64; (2013); p. 477 - 487, View in Reaxys

Cao, Jin-Li; Shen, Su-Li; Yang, Peng; Qu, Jin; Organic Letters; vol. 15; nb. 15; (2013); p. 3856 - 3859, View in Reaxys

Mibu, Nobuko; Yokomizo, Kazumi; Takemura, Satoshi; Ueki, Nami; Itohara, Saki; Zhou, Jianrong; Miyata, Takeshi; Sumoto, Kunihiro; Chemical and Pharmaceutical Bulletin; vol. 61; nb. 8; (2013); p. 823 833, View in Reaxys

Rao, Yin; Yin, Guodong; Organic and Biomolecular Chemistry; vol. 11; nb. 36; (2013); p. 6029 - 6035, View in Reaxys

4a1

Patent; Sun, Shaoyi; Fu, Jianmin; Chowdhury, Sultan; Hemeon, Ivan William; Grimwood, Michael Edward; Mansour, Tarek Suhayl; US2013/274483; (2013); (A1) English, View in Reaxys

Kumar, Praveen; Shrivastava, Birendra; Pandeya, Surendra N.; Tripathi, Laxmi; Stables, James P.; Medicinal Chemistry Research; vol. 21; nb. 9; (2012); p. 2428 - 2442, View in Reaxys

3{5}

Shestopalov, Anatoliy M.; Litvinov, Yuri M.; Rodinovskaya, Lyudmila A.; Malyshev, Oleg R.; Semenova, Marina N.; Semenov, Victor V.; ACS Combinatorial Science; vol. 14; nb. 8; (2012); p. 484 - 490, View in Reaxys

12b

Chang, Junbiao; Wang, Shuyang; Shen, Zhenhua; Huang, Gang; Zhang, Yueteng; Zhao, Jing; Li, Changwei; Fan, Fangfang; Song, Chuanjun; Tetrahedron Letters; vol. 53; nb. 50; (2012); p. 6755 - 6757,3, View in Reaxys

Li, Minghao; Zhang, Biao; Gu, Yanlong; Green Chemistry; vol. 14; nb. 9; (2012); p. 2421 - 2428, View in Reaxys

Patent; OHIO STATE UNIVERSITY RESEARCH FOUNDATION; INVASC THERAPEUTICS, INC.; US2010/35849; (2010); (A1) English, View in Reaxys

Product (entry 1)

Da Silva, Emerson Teixeira; Camara, Celso Amorim; Antunes; Barreiro, Eliezer J.; Fraga, Carlos A. M.; Synthetic Communications; vol. 38; nb. 5; (2008); p. 784 - 788, View in Reaxys

SOH

Joshi; Naumov; Kapoor; Mukherjee; Hermann; Brede; Journal of Physical Organic Chemistry; vol. 17; nb. 8; (2004); p. 665 - 674, View in Reaxys; Joshi, Ravi; Kumar, M. Sudheer; Satyamoorthy; Unnikrisnan; Mukherjee, Tulsi; Journal of Agricultural and Food Chemistry; vol. 53; nb. 7; (2005); p. 2696 - 2703, View in Reaxys; Joshi, Ravi; Kapoor; Mukherjee; Journal of Physical Organic Chemistry; vol. 20; nb. 3; (2007); p. 214 - 220, View in Reaxys

1, R%4&=3,4OCH2O

Yamazaki, Yukiyoshi; Abe, Kazutoyo; Toma, Tsutomu; Nishikawa, Masahiro; Ozawa, Hidefumi; Okuda, Ayumu; Araki, Takaaki; Oda, Soichi; Inoue, Keisuke; Shibuya, Kimiyuki; Staels, Bart; Fruchart, JeanCharles; Bioorganic and Medicinal Chemistry Letters; vol. 17; nb. 16; (2007); p. 4689 - 4693, View in Reaxys

Juhasz, Laszlo; Docsa, Tibor; Brunyaszki, Attila; Gergely, Pal; Antus, Sandor; Bioorganic and Medicinal Chemistry; vol. 15; nb. 12; (2007); p. 4048 - 4056, View in Reaxys

Krawczyk, Henryk; Albrecht, Lukasz; Wojciechowski, Jakub; Wolf, Wojciech M.; Tetrahedron; vol. 63; nb. 51; (2007); p. 12583 - 12594, View in Reaxys

Maiti, Soumen; Sengupta, Sujaya; Giri, Chandana; Achari, Basudeb; Banerjee, Asish Kr.; Tetrahedron Letters; vol. 42; nb. 12; (2001); p. 2389 - 2391, View in Reaxys; Bezerra-Netto, Heleno J.C.; Lacerda, Daniel I.; Miranda, Ana Luisa P.; Alves, Helio M.; Barreiro, Eliezer J.; Fraga, Carlos A.M.; Bioorganic and Medicinal Chemistry; vol. 14; nb. 23; (2006); p. 7924 - 7935, View in Reaxys; Cueva, Juan Pablo; Giorgioni, Gianfabio; Grubbs, Russell A.; Chemel, Benjamin R.; Watts, Val J.; Nichols, David E.; Journal of Medicinal Chemistry; vol. 49; nb. 23; (2006); p. 6848 - 6857, View in Reaxys; Vasquez-Martinez, Yesseny; Ohri, Rachana V.; Kenyon, Victor; Holman, Theodore R.; Sepulveda-Boza, Silvia; Bioorganic and Medicinal Chemistry; vol. 15; nb. 23; (2007); p. 7408 - 7425, View in Reaxys

educt of 22

Malkowsky, Itamar M.; Frohlich, Roland; Griesbach, Ulrich; Puetter, Hermann; Waldvogel, Siegfried R.; European Journal of Inorganic Chemistry; nb. 8; (2006); p. 1690 - 1697, View in Reaxys

Kumar, Manyam Praveen; Liu, Rai-Shung; Journal of Organic Chemistry; vol. 71; nb. 13; (2006); p. 4951 4955, View in Reaxys

Oyamada, Juzo; Kitamura, Tsugio; Tetrahedron; vol. 62; nb. 29; (2006); p. 6918 - 6925, View in Reaxys

6/88

2017-10-14 23:10:10

Parihar, Vipan Kumar; Prabhakar; Veerapur, Veeresh P.; Kumar, M. Sudheer; Reddy, Y. Rosi; Joshi, Ravi; Unnikrishnan; Rao, C. Mallikarjuna; Mutation Research - Genetic Toxicology and Environmental Mutagenesis; vol. 611; nb. 1-2; (2006); p. 9 - 16, View in Reaxys

Jimenez-Gonzalez, Leticia; Garcia-Munoz, Sergio; Alvarez-Corral, Miriam; Munoz-Dorado, Manuel; Rodriguez-Garcia, Ignacio; Chemistry - A European Journal; vol. 12; nb. 34; (2006); p. 8762 - 8769, View in Reaxys

Sabitha, Gowravaram; Abraham, Sunny; Reddy, B. V. Subba; Yadav; Synlett; nb. 11; (1999); p. 1745 1746, View in Reaxys; Sa E Sant'Anna; Evangelista; Alves; Raslan; Chemistry of Natural Compounds; vol. 41; nb. 4; (2005); p. 385 - 387, View in Reaxys

Kitamura, Tsugio; Yamamoto, Kiyomi; Kotani, Masashi; Oyamada, Juzo; Jia, Chengguo; Fujiwara, Yuzo; Bulletin of the Chemical Society of Japan; vol. 76; nb. 10; (2003); p. 1889 - 1895, View in Reaxys; Aoki, Shinya; Amamoto, Chie; Oyamada, Juzo; Kitamura, Tsugio; Tetrahedron; vol. 61; nb. 39; (2005); p. 9291 - 9297, View in Reaxys

prod., Tab. 1, entry 8

Semwal, Abha; Nayak, Sandip K.; Synthesis; nb. 1; (2005); p. 71 - 74; Art.No: Z16603SS, View in Reaxys

16b

Alvarez-Manzaneda; Chahboun; Barranco Perez; Cabrera; Alvarez; Organic Letters; vol. 7; nb. 8; (2005); p. 1477 - 1480, View in Reaxys

Rondot, Christophe; Zhu, Jieping; Organic Letters; vol. 7; nb. 8; (2005); p. 1641 - 1644, View in Reaxys

Del Carmen Cruz, Maria; Tamariz, Joaquin; Tetrahedron; vol. 61; nb. 42; (2005); p. 10061 - 10072, View in Reaxys

phenol der. for 16

Kumazawa, Keiko; Ishihara, Kazuaki; Yamamoto, Hisashi; Organic Letters; vol. 6; nb. 15; (2004); p. 2551 - 2554, View in Reaxys

Ses

Fukuoka, Kansuke; Sawabe, Akiyoshi; Sugimoto, Takeo; Koga, Motoki; Okuda, Hiroshi; Kitayama, Takashi; Shirai, Mutsunori; Komai, Koichiro; Komemushi, Sadao; Matsuda, Kazuhiko; Journal of Agricultural and Food Chemistry; vol. 52; nb. 20; (2004); p. 6326 - 6329, View in Reaxys

Dintzner, Matthew R.; McClelland, Kristen M.; Morse, Kara M.; Akroush, Michael H.; Synlett; nb. 11; (2004); p. 2028 - 2030, View in Reaxys

P-14

Pernerstorfer, Josef; Brands, Michael; Schirok, Hartmut; Stelte-Ludwig, Beatrix; Woltering, Elisabeth; Tetrahedron; vol. 60; nb. 39; (2004); p. 8627 - 8632, View in Reaxys

Kubota, Hideki; Watanabe, Toshihiro; Kakefuda, Akio; Masuda, Noriyuki; Wada, Kouichi; Ishii, Noe; Sakamoto, Shuichi; Tsukamoto, Shinichi; Bioorganic and Medicinal Chemistry; vol. 12; nb. 5; (2004); p. 871 - 882, View in Reaxys

Cruz, Maria Del Carmen; Tamariz, Joaquin; Tetrahedron Letters; vol. 45; nb. 11; (2004); p. 2377 - 2380, View in Reaxys

Nam, Nguyen-Hai; Kim, Yong; You, Young-Jae; Hong, Dong-Ho; Kim, Hwan-Mook; Ahn, Byung-Zun; Bioorganic and medicinal chemistry letters; vol. 12; nb. 17; (2002); p. 2345 - 2348, View in Reaxys; Lizarzaburu, Mike E.; Shuttleworth, Stephen J.; Tetrahedron Letters; vol. 44; nb. 26; (2003); p. 4873 - 4876, View in Reaxys

Zambrano, Jorge L.; Dortab, Romano; Synlett; nb. 10; (2003); p. 1545 - 1546, View in Reaxys

Gill, Christopher D.; Greenhalgh, Daniel A.; Simpkins, Nigel S.; Tetrahedron; vol. 59; nb. 46; (2003); p. 9213 - 9230, View in Reaxys

tab1 arene ent.j

Yadav; Reddy; Veerendhar; Srinivasa Rao; Nagaiah; Chemistry Letters; nb. 3; (2002); p. 318 - 319, View in Reaxys

Pirrung; Fallon; Zhu; Yong Rok Lee; Journal of the American Chemical Society; vol. 123; nb. 16; (2001); p. 3638 - 3643, View in Reaxys

product entry d

Yadav; Reddy, B. V. Subba; Chemistry Letters; nb. 5; (2000); p. 566 - 567, View in Reaxys

3ah

Szurdoki, Ferenc; Ren, Dahai; Walt, David R.; Analytical Chemistry; vol. 72; nb. 21; (2000); p. 5250 - 5257, View in Reaxys

11d

Clayden, Jonathan; Helliwell, Madeleine; McCarthy, Catherine; Westlund, Neil; Journal of the Chemical Society, Perkin Transactions 1; nb. 19; (2000); p. 3232 - 3249, View in Reaxys

Tab. 1, note e

Watanabe, Makoto; Nishiyama, Masakazu; Koie, Yasuyuki; Tetrahedron Letters; vol. 40; nb. 50; (1999); p. 8837 - 8840, View in Reaxys

Patent-Specific Data (9) Prophetic ComLocation in Patent References pound

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2017-10-14 23:10:10

Patent; Haimen Wisdom Pharmaceutical Co., Ltd.,; Haimen Bai Kang Biopharma Co., Ltd.; Southeast University; Zou, ping; Wei, Wanguo; Qiu, Xiao-Long; Hu, Zhong-ping; Zeng, Xiangjun; Zhang, Xin-gang; Peng, Zhihu; Wang, Donghui; Zhang, Yi-sen; Deng, Xianming; You, Zheng-Wei; Jiang, Zhong-Xing; Hu, Lin; Cao, Lei; Chen, Jun; Gou, Shao-Hua; (10 pag.); CN106518886; (2017); (A) Chinese, View in Reaxys Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; HARTWIG, John; FIER, Patrick; WO2014/107380; (2014); (A1) English, View in Reaxys Page/Page column

Patent; Hasvold, Lisa A.; Pratt, John; McDaniel, Keith F.; Sheppard, George S.; Liu, Dachun; Elmore, Steven W.; Hubbard, Robert D.; US2014/275079; (2014); (A1) English, View in Reaxys; Patent; Janssen Pharmaceutica NV; Sui, Zhihua; Subasinghe, Nalin; US2014/275172; (2014); (A1) English, View in Reaxys Patent; ACTELION PHARMACEUTICALS LTD; BOLLI, Martin; BOSS, Christoph; BROTSCHI, Christine; GUDE, Markus; HEIDMANN, Bibia; SIFFERLEN, Thierry; WILLIAMS, Jodi, T.; WO2012/110986; (2012); (A1) English, View in Reaxys Patent; ENDURA S.P.A.; ROTHAMSTED RESEARCH LTD.; BORZATTA, Valerio; CAPPARELLA, Elisa; MORONI, Leni; MOORES, Graham; PHILIPPOU, Despina; WO2011/20848; (2011); (A1) English, View in Reaxys Patent; ALMIRALL PRODESFARMA, SA; WO2006/133802; (2006); (A1) English, View in Reaxys Patent; ENDURA S.P.A.; WO2004/92106; (2004); (A2) English, View in Reaxys Patent; Pfizer Products Inc.; EP1229034; (2002); (A1) English, View in Reaxys

prophetic product

Patent; Merck Patent Gesellschaft mit Beschrankter Haftung; US5821256; (1998); (A1) English, View in Reaxys

Druglikeness (1) 1 of 1

LogP

1.105

H Bond Donors

H Bond Acceptors

Rotatable Bonds

TPSA

38.69

Lipinski Number

Veber Number

Derivative (1) Comment (Derivative) compound with 2(?) mol all-transretinal (mp: 78.2-78.6 degree , yellow); Further Data see Handbook

References Patent; Eastman Kodak Co.; US2835679; (1955), View in Reaxys

Melting Point (15) 1 of 15

Melting Point [°C]

Location

supporting information

Gangar, Mukesh; Chouhan, Mangilal; Goyal, Sandeep; Harikrishnan; Chandran; Ittuveetil, Avinash; Nair, Vipin A.; Tetrahedron Letters; vol. 57; nb. 52; (2016); p. 5931 - 5934, View in Reaxys 2 of 15

Melting Point [°C]

59 - 61

Location

supporting information

Yu, Chao-Wu; Chen, Grace S.; Huang, Chen-Wei; Chern, Ji-Wang; Organic Letters; vol. 14; nb. 14; (2012); p. 3688 - 3691, View in Reaxys 3 of 15

Melting Point [°C]

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2017-10-14 23:10:10

Singh, Pragya; Faridi, Uzma; Srivastava, Suchita; Kumar, Jonnala Kotesh; Darokar, Mahender Pandurang; Luqman, Suaib; Shanker, Karuna; Chanotiya, Chandan Singh; Gupta, Atul; Gupta, Madan Mohan; Negi, Arvind Singh; Chemical and Pharmaceutical Bulletin; vol. 58; nb. 2; (2010); p. 242 - 246, View in Reaxys 4 of 15

Melting Point [°C]

60 - 62

Da Silva, Emerson Teixeira; Camara, Celso Amorim; Antunes; Barreiro, Eliezer J.; Fraga, Carlos A. M.; Synthetic Communications; vol. 38; nb. 5; (2008); p. 784 - 788, View in Reaxys 5 of 15

Melting Point [°C]

62 - 63.5

Solvent (Melting Point)

hexane

Duan, Xin-Fang; Zeng, Jing; Zhang, Zhan-Bin; Zi, Guo-Fu; Journal of Organic Chemistry; vol. 72; nb. 26; (2007); p. 10283 - 10286, View in Reaxys 6 of 15

Melting Point [°C]

64.58

Matos, M. Agostinha R.; Monte, Manuel J.S.; Sousa, Clara C.S.; Almeida, Ana R.R.P.; Morais, Victor M.F.; Organic and Biomolecular Chemistry; vol. 2; nb. 6; (2004); p. 908 - 914, View in Reaxys 7 of 15

Melting Point [°C]

63 - 65

Solvent (Melting Point)

cyclohexane; dichloromethane

Patent; ENDURA S.P.A.; WO2004/92106; (2004); (A2) English, View in Reaxys 8 of 15

Melting Point [°C]

63 - 64

Patent; DAICEL CHEMICAL INDUSTRIES, Ltd.; EP1167365; (2002); (A1) English, View in Reaxys; Minamikawa; Brossi; Tetrahedron Letters; (1978); p. 3085, View in Reaxys 9 of 15

Melting Point [°C]

62 - 63

Webb, Kevin S.; Ruszkay, Stephen J.; Tetrahedron; vol. 54; nb. 3-4; (1998); p. 401 - 410, View in Reaxys 10 of 15

Melting Point [°C]

64 - 65

Orphanos,D.G.; Taurin,A.; Canadian Journal of Chemistry; vol. 44; (1966); p. 1875 - 1879, View in Reaxys 11 of 15

Melting Point [°C]

Solvent (Melting Point)

toluene

Ohno et al.; Bulletin of the Institute for Chemical Research, Kyoto University; vol. 38; (1960); p. 34,38; Chem.Abstr.; nb. 22275d; (1961), View in Reaxys 12 of 15

Melting Point [°C]

Solvent (Melting Point)

toluene; CHCl3

Ohno et al.; Bulletin of the Institute for Chemical Research, Kyoto University; vol. 38; (1960); p. 34,38; Chem.Abstr.; nb. 22275d; (1961), View in Reaxys 13 of 15

Solvent (Melting Point)

petroleum ether

Wilkinson; Biochemical Journal; vol. 63; (1956); p. 601,603, View in Reaxys 14 of 15

Melting Point [°C]

64.5

Wilkinson; Biochemical Journal; vol. 63; (1956); p. 601,603, View in Reaxys 15 of 15

Melting Point [°C]

65.8

Boeeseken et al.; Recueil des Travaux Chimiques des Pays-Bas; vol. 55; (1936); p. 815,817, View in Reaxys Boiling Point (3) Boiling Point [°C]

Pressure (Boiling Point) [Torr]

References

116

17.2517

Patent; ENDURA S.P.A.; WO2004/92106; (2004); (A2) English, View in Reaxys

116

2.25023 - 3.0003

Patent; ENDURA S.P.A.; WO2004/92106; (2004); (A2) English, View in Reaxys

113 - 116

Ohno et al.; Bulletin of the Institute for Chemical Research, Kyoto University; vol. 38; (1960); p. 34,38; Chem.Abstr.; nb. 22275d; (1961), View in Reaxys

Chromatographic Data (1) Chromatographic Location data

References

9/88

2017-10-14 23:10:10

TLC (Thin layer chromatography)

supporting information

Crystal Property Description (7) Colour & Other Location Properties

He, Zhi; Jamison, Timothy F.; Angewandte Chemie - International Edition; vol. 53; nb. 13; (2014); p. 3353 - 3357; Angew. Chem.; vol. 126; nb. 13; (2014); p. 3421 - 3425,5, View in Reaxys References

white

supporting information

Xia, Shanghua; Gan, Lu; Wang, Kailiang; Li, Zheng; Ma, Dawei; Journal of the American Chemical Society; vol. 138; nb. 41; (2016); p. 13493 - 13496, View in Reaxys; Gangar, Mukesh; Chouhan, Mangilal; Goyal, Sandeep; Harikrishnan; Chandran; Ittuveetil, Avinash; Nair, Vipin A.; Tetrahedron Letters; vol. 57; nb. 52; (2016); p. 5931 - 5934, View in Reaxys

colourless

supporting information

He, Zhi; Jamison, Timothy F.; Angewandte Chemie - International Edition; vol. 53; nb. 13; (2014); p. 3353 - 3357; Angew. Chem.; vol. 126; nb. 13; (2014); p. 3421 - 3425,5, View in Reaxys

white

brown

Hwang, Hong-Sik; Winkler-Moser, Jill K.; Bakota, Erica L.; Berhow, Mark A.; Liu, Sean X.; JAOCS, Journal of the American Oil Chemists' Society; vol. 90; nb. 5; (2013); p. 659 - 666, View in Reaxys supporting information

Yu, Chao-Wu; Chen, Grace S.; Huang, Chen-Wei; Chern, Ji-Wang; Organic Letters; vol. 14; nb. 14; (2012); p. 3688 - 3691, View in Reaxys

brown - red

light-yellow

Bezerra-Netto, Heleno J.C.; Lacerda, Daniel I.; Miranda, Ana Luisa P.; Alves, Helio M.; Barreiro, Eliezer J.; Fraga, Carlos A.M.; Bioorganic and Medicinal Chemistry; vol. 14; nb. 23; (2006); p. 7924 - 7935, View in Reaxys

65.5

Adriani; Z. Nahr.-Genussm.; vol. 56; p. 187; Chem. Zentralbl.; vol. 100; nb. I; (1929); p. 1012, View in Reaxys

Electrical Moment (2) 1 of 2

Description (Electrical Moment)

Dipole moment

Moment (Electrical Moment) [D]

2.275

Solvent (Electrical Moment)

benzene

Joshi, Ravi; Kapoor; Mukherjee; Journal of Physical Organic Chemistry; vol. 20; nb. 3; (2007); p. 214 - 220, View in Reaxys 2 of 2

Description (Electrical Moment)

Dipole moment

Moment (Electrical Moment) [D]

2.015

Solvent (Electrical Moment)

cyclohexane

Joshi, Ravi; Kapoor; Mukherjee; Journal of Physical Organic Chemistry; vol. 20; nb. 3; (2007); p. 214 - 220, View in Reaxys Electrochemical Characteristics (4) 1 of 4

Description (Electrochemical Characteristics)

cyclovoltammetry

Solvent (Electrochemical Characteristics)

acetonitrile

Location

supporting information

Comment (Electrochem- Saturated calomel electrode (SCE); potential diagram ical Characteristics) Zhao, Yating; Huang, Binbin; Yang, Chao; Xia, Wujiong; Organic Letters; vol. 18; nb. 14; (2016); p. 3326 - 3329, View in Reaxys

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2017-10-14 23:10:10

2 of 4

Description (Electrochemical Characteristics)

Electrochemical characteristics given

Arteaga, Jesus F.; Ruiz-Montoya, Mercedes; Palma, Alberto; Alonso-Garrido, Gema; Pintado, Sara; Rodriguez-Mellad, Jose M.; Molecules; vol. 17; nb. 5; (2012); p. 5126 - 5138, View in Reaxys 3 of 4

Description (Electrochemical Characteristics)

oxidation potential

Solvent (Electrochemical Characteristics)

H2O

pH-Value (Electrochemi- 7 cal Characteristics) Joshi, Ravi; Kumar, M. Sudheer; Satyamoorthy; Unnikrisnan; Mukherjee, Tulsi; Journal of Agricultural and Food Chemistry; vol. 53; nb. 7; (2005); p. 2696 - 2703, View in Reaxys 4 of 4

Description (Electrochemical Characteristics)

cyclic voltammetry

Solvent (Electrochemical Characteristics)

H2O

Pressure (Enthalpy of Combustion) [Torr]

References

-3.1942E+06

750.075

Matos, M. Agostinha R.; Monte, Manuel J.S.; Sousa, Clara C.S.; Almeida, Ana R.R.P.; Morais, Victor M.F.; Organic and Biomolecular Chemistry; vol. 2; nb. 6; (2004); p. 908 - 914, View in Reaxys

Enthalpy of Formation (1) Enthalpy of ForTemperature (Enmation [Jmol-1] thalpy of Formation) [°C]

Pressure (Enthalpy of Formation) [Torr]

References

417900

750.075

Matos, M. Agostinha R.; Monte, Manuel J.S.; Sousa, Clara C.S.; Almeida, Ana R.R.P.; Morais, Victor M.F.; Organic and Biomolecular Chemistry; vol. 2; nb. 6; (2004); p. 908 - 914, View in Reaxys

24.94

Enthalpy of Fusion (1) Enthalpy of FuReferences sion [Jmol-1] 16960

Matos, M. Agostinha R.; Monte, Manuel J.S.; Sousa, Clara C.S.; Almeida, Ana R.R.P.; Morais, Victor M.F.; Organic and Biomolecular Chemistry; vol. 2; nb. 6; (2004); p. 908 - 914, View in Reaxys

Further Information (1) Description (Fur- References ther Information) behaviour as inhibitor

Hwang, Hong-Sik; Winkler-Moser, Jill K.; Bakota, Erica L.; Berhow, Mark A.; Liu, Sean X.; JAOCS, Journal of the American Oil Chemists' Society; vol. 90; nb. 5; (2013); p. 659 - 666, View in Reaxys

Partition octan-1-ol/water (MCS) (1) 1 of 1

log POW

1.37

Garca-Sosa, Alfonso T.; Maran, Uko; Journal of Chemical Information and Modeling; vol. 54; nb. 11; (2014); p. 3172 - 3185, View in Reaxys Solubility (MCS) (1) 1 of 1

Comment (Solubility (MCS))

water soluble

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Vapour Pressure (1)

11/88

2017-10-14 23:10:10

Vapour Pressure [Torr]

Temperature (Vapour Pressure) [°C]

Comment (Vapour Pressure)

References

0.134 - 0.942

20.06 - 35.98

Diagram exists; Equation: p=(Δm/A0w0t) (2πRT/M)1/2

Matos, M. Agostinha R.; Monte, Manuel J.S.; Sousa, Clara C.S.; Almeida, Ana R.R.P.; Morais, Victor M.F.; Organic and Biomolecular Chemistry; vol. 2; nb. 6; (2004); p. 908 - 914, View in Reaxys

NMR Spectroscopy (16) 1 of 16

Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)

Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]

400

Location

supporting information

Xia, Shanghua; Gan, Lu; Wang, Kailiang; Li, Zheng; Ma, Dawei; Journal of the American Chemical Society; vol. 138; nb. 41; (2016); p. 13493 - 13496, View in Reaxys 2 of 16

Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)

13C

Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]

100

Location

supporting information

Xia, Shanghua; Gan, Lu; Wang, Kailiang; Li, Zheng; Ma, Dawei; Journal of the American Chemical Society; vol. 138; nb. 41; (2016); p. 13493 - 13496, View in Reaxys 3 of 16

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]

400

Location

supporting information

Gangar, Mukesh; Chouhan, Mangilal; Goyal, Sandeep; Harikrishnan; Chandran; Ittuveetil, Avinash; Nair, Vipin A.; Tetrahedron Letters; vol. 57; nb. 52; (2016); p. 5931 - 5934, View in Reaxys 4 of 16

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

13C

Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]

100

Location

supporting information

Gangar, Mukesh; Chouhan, Mangilal; Goyal, Sandeep; Harikrishnan; Chandran; Ittuveetil, Avinash; Nair, Vipin A.; Tetrahedron Letters; vol. 57; nb. 52; (2016); p. 5931 - 5934, View in Reaxys

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5 of 16

Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)

Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]

Location

supporting information

Khazaei, Ardeshir; Saednia, Shahnaz; Roshani, Liela; Kazem-Rostami, Masoud; Zare, Abdolkarim; Letters in Organic Chemistry; vol. 11; nb. 3; (2014); p. 159 - 167, View in Reaxys 6 of 16

Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)

Solvents (NMR Spectro- chloroform-d1 scopy) Location

supporting information

Bai, Sha; Liao, Yuting; Lin, Lili; Luo, Weiwei; Liu, Xiaohua; Feng, Xiaoming; Journal of Organic Chemistry; vol. 79; nb. 21; (2014); p. 10662 - 10668, View in Reaxys 7 of 16

Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)

Solvents (NMR Spectro- dimethylsulfoxide-d6 scopy) Frequency (NMR Spectroscopy) [MHz]

400

Location

supporting information

Yu, Chao-Wu; Chen, Grace S.; Huang, Chen-Wei; Chern, Ji-Wang; Organic Letters; vol. 14; nb. 14; (2012); p. 3688 - 3691, View in Reaxys 8 of 16

Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)

13C

Solvents (NMR Spectro- dimethylsulfoxide-d6 scopy) Frequency (NMR Spectroscopy) [MHz]

100

Location

supporting information

Yu, Chao-Wu; Chen, Grace S.; Huang, Chen-Wei; Chern, Ji-Wang; Organic Letters; vol. 14; nb. 14; (2012); p. 3688 - 3691, View in Reaxys 9 of 16

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

Solvents (NMR Spectro- chloroform-d1 scopy) Singh, Pragya; Faridi, Uzma; Srivastava, Suchita; Kumar, Jonnala Kotesh; Darokar, Mahender Pandurang; Luqman, Suaib; Shanker, Karuna; Chanotiya, Chandan Singh; Gupta, Atul; Gupta, Madan Mohan; Negi, Arvind Singh; Chemical and Pharmaceutical Bulletin; vol. 58; nb. 2; (2010); p. 242 - 246, View in Reaxys

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Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

13C

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

Solvents (NMR Spectro- CDCl3 scopy) Frequency (NMR Spectroscopy) [MHz]

200

Da Silva, Emerson Teixeira; Camara, Celso Amorim; Antunes; Barreiro, Eliezer J.; Fraga, Carlos A. M.; Synthetic Communications; vol. 38; nb. 5; (2008); p. 784 - 788, View in Reaxys 12 of 16

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

Solvents (NMR Spectro- CDCl3 scopy) Frequency (NMR Spectroscopy) [MHz]

300

Webb, Kevin S.; Ruszkay, Stephen J.; Tetrahedron; vol. 54; nb. 3-4; (1998); p. 401 - 410, View in Reaxys 13 of 16

Nucleus (NMR Spectroscopy)

Coupling Nuclei

Solvents (NMR Spectro- CDCl3 scopy) Frequency (NMR Spectroscopy) [MHz]

300

Webb, Kevin S.; Ruszkay, Stephen J.; Tetrahedron; vol. 54; nb. 3-4; (1998); p. 401 - 410, View in Reaxys 14 of 16

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

Solvents (NMR Spectro- CDCl3 scopy) Saito, Naoki; Tashiro, Kyoichi; Maru, Yukie; Yamaguchi, Kentaro; Kubo, Akinori; Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999); nb. 1; (1997); p. 53 - 70, View in Reaxys 15 of 16

Description (NMR Spec- Spin-spin coupling constants troscopy) Solvents (NMR Spectro- CDCl3 scopy) Comment (NMR Spectroscopy)

1H-1H

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Saito, Naoki; Tashiro, Kyoichi; Maru, Yukie; Yamaguchi, Kentaro; Kubo, Akinori; Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999); nb. 1; (1997); p. 53 - 70, View in Reaxys 16 of 16

Description (NMR Spec- Spectrum troscopy) Nucleus (NMR Spectroscopy)

Solvents (NMR Spectro- CDCl3 scopy) Wu, Shao-Yong; Ito, Shigekazu; Eto, Morifusa; Agricultural and Biological Chemistry; vol. 51; nb. 11; (1987); p. 2935 - 2942, View in Reaxys IR Spectroscopy (3) 1 of 3

Description (IR Spectroscopy)

Bands; Spectrum

Solvent (IR Spectroscopy)

potassium bromide

Location

supporting information

Khazaei, Ardeshir; Saednia, Shahnaz; Roshani, Liela; Kazem-Rostami, Masoud; Zare, Abdolkarim; Letters in Organic Chemistry; vol. 11; nb. 3; (2014); p. 159 - 167, View in Reaxys 2 of 3

Description (IR Spectroscopy)

Spectrum

Comment (IR Spectroscopy)

ambient temperature

Mirghani; Che Man; Jinap; Baharin; Bakar; JAOCS, Journal of the American Oil Chemists' Society; vol. 80; nb. 1; (2003); p. 1 - 4, View in Reaxys 3 of 3

Description (IR Spectroscopy)

Bands

Comment (IR Spectroscopy)

ambient temperature

Mirghani; Che Man; Jinap; Baharin; Bakar; JAOCS, Journal of the American Oil Chemists' Society; vol. 80; nb. 1; (2003); p. 1 - 4, View in Reaxys Mass Spectrometry (3) Description (Mass Location Spectrometry)

References

high resolution supporting informass spectrome- mation try (HRMS); electrospray ionisation (ESI); timeof-flight mass spectra (TOFMS); spectrum

Gangar, Mukesh; Chouhan, Mangilal; Goyal, Sandeep; Harikrishnan; Chandran; Ittuveetil, Avinash; Nair, Vipin A.; Tetrahedron Letters; vol. 57; nb. 52; (2016); p. 5931 5934, View in Reaxys

ESI (Electrospray ionisation); Spectrum

Negative ion spectroscopy; LCMS (Liquid chromatography mass spectrometry); CID (collision-induced dissociation); Spectrum

Jan, Kuo-Ching; Ho, Chi-Tang; Hwang, Lucy Sun; Journal of Agricultural and Food Chemistry; vol. 56; nb. 16; (2008); p. 7032 - 7037, View in Reaxys

UV/VIS Spectroscopy (12)

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Description (UV/VIS Spectroscopy)

Spectrum

Solvent (UV/VIS Spectroscopy)

acetonitrile

Absorption Maxima (UV/ 235; 286 VIS) [nm] Ext./Abs. Coefficient [l·mol-1cm-1]

5950; 5540

Yang, Jinliang; Xu, Fei; Shi, Suqing; Nie, Jun; Photochemical and Photobiological Sciences; vol. 11; nb. 8; (2012); p. 1377 - 1382, View in Reaxys 2 of 12

Solvent (UV/VIS Spectroscopy)

aq. buffer

Absorption Maxima (UV/ 296 VIS) [nm] Mahendra Kumar; Sathisha; Dharmesh, Shylaja; Rao, A.G. Appu; Singh, Sridevi A.; Biochimie; vol. 93; nb. 3; (2011); p. 562 - 569, View in Reaxys 3 of 12

Description (UV/VIS Spectroscopy)

in the presence of additive(s)

Solvent (UV/VIS Spectroscopy)

water

Absorption Maxima (UV/ 294 VIS) [nm] Ext./Abs. Coefficient [l·mol-1cm-1]

3700

Makino, Yumi; Uchiyama, Seiichi; Ohno, Ken-Ichi; Arakawa, Hidetoshi; Analytical Chemistry; vol. 82; nb. 4; (2010); p. 1213 - 1220, View in Reaxys 4 of 12

Solvent (UV/VIS Spectroscopy)

dimethyl sulfoxide

Absorption Maxima (UV/ 301 VIS) [nm] Ext./Abs. Coefficient [l·mol-1cm-1]

4200

Makino, Yumi; Uchiyama, Seiichi; Ohno, Ken-Ichi; Arakawa, Hidetoshi; Analytical Chemistry; vol. 82; nb. 4; (2010); p. 1213 - 1220, View in Reaxys 5 of 12

Solvent (UV/VIS Spectroscopy)

N,N-dimethyl-formamide

Absorption Maxima (UV/ 300 VIS) [nm] Ext./Abs. Coefficient [l·mol-1cm-1]

4700

Makino, Yumi; Uchiyama, Seiichi; Ohno, Ken-Ichi; Arakawa, Hidetoshi; Analytical Chemistry; vol. 82; nb. 4; (2010); p. 1213 - 1220, View in Reaxys 6 of 12

Solvent (UV/VIS Spectroscopy)

acetonitrile

Absorption Maxima (UV/ 298 VIS) [nm] Ext./Abs. Coefficient [l·mol-1cm-1]

4200

Makino, Yumi; Uchiyama, Seiichi; Ohno, Ken-Ichi; Arakawa, Hidetoshi; Analytical Chemistry; vol. 82; nb. 4; (2010); p. 1213 - 1220, View in Reaxys 7 of 12

Solvent (UV/VIS Spectroscopy)

ethanol

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Absorption Maxima (UV/ 298 VIS) [nm] Ext./Abs. Coefficient [l·mol-1cm-1]

4300

Makino, Yumi; Uchiyama, Seiichi; Ohno, Ken-Ichi; Arakawa, Hidetoshi; Analytical Chemistry; vol. 82; nb. 4; (2010); p. 1213 - 1220, View in Reaxys 8 of 12

Solvent (UV/VIS Spectroscopy)

methanol

Absorption Maxima (UV/ 298 VIS) [nm] Ext./Abs. Coefficient [l·mol-1cm-1]

4400

Makino, Yumi; Uchiyama, Seiichi; Ohno, Ken-Ichi; Arakawa, Hidetoshi; Analytical Chemistry; vol. 82; nb. 4; (2010); p. 1213 - 1220, View in Reaxys 9 of 12

Description (UV/VIS Spectroscopy)

Spectrum

Solvent (UV/VIS Spectroscopy)

H2O

Nakagawa, Kouichi; JAOCS, Journal of the American Oil Chemists' Society; vol. 77; nb. 11; (2000); p. 1205 - 1208, View in Reaxys 10 of 12

Solvent (UV/VIS Spectroscopy)

H2O

Comment (UV/VIS Spectroscopy)

Remark: pH 5-6

Absorption Maxima (UV/ 294 VIS) [nm] Ext./Abs. Coefficient [l·mol-1cm-1]

4700

Chen; Ahn; JAOCS, Journal of the American Oil Chemists' Society; vol. 75; nb. 12; (1998); p. 1717 - 1721, View in Reaxys 11 of 12

Description (UV/VIS Spectroscopy)

Absorption maxima

Solvent (UV/VIS Spectroscopy)

ethanol

Absorption Maxima (UV/ 295; 233 VIS) [nm] Kurechi; Kikugawa; Aoshima; Chemical and Pharmaceutical Bulletin; vol. 29; nb. 8; (1981); p. 2351 - 2358, View in Reaxys 12 of 12

Description (UV/VIS Spectroscopy)

UV/VIS

Kurechi et al.; Chemical and Pharmaceutical Bulletin; vol. 27; (1979); p. 2442,2443,2446,2447, View in Reaxys Fluorescence Spectroscopy (7) Description (Fluo- Solvent (Fluoresrescence Speccence Spectrotroscopy) scopy)

Comment (Fluorescence Spectroscopy)

Fluorescence

References

Makino, Yumi; Uchiyama, Seiichi; Ohno, Ken-Ichi; Arakawa, Hidetoshi; Analytical Chemistry; vol. 82; nb. 4; (2010); p. 1213 1220, View in Reaxys

Maxima

H2O

Joshi, Ravi; Kapoor; Mukherjee; Journal of Physical Organic Chemistry; vol. 20; nb. 3; (2007); p. 214 - 220, View in Reaxys

Maxima

benzene

Joshi, Ravi; Kapoor; Mukherjee; Journal of Physical Organic Chemistry; vol. 20; nb. 3; (2007); p. 214 - 220, View in Reaxys

Maxima

cyclohexane

Joshi, Ravi; Kapoor; Mukherjee; Journal of Physical Organic Chemistry; vol. 20; nb. 3; (2007); p. 214 - 220, View in Reaxys

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Fluorescence lifetime

solvent dependence

Joshi, Ravi; Kapoor; Mukherjee; Journal of Physical Organic Chemistry; vol. 20; nb. 3; (2007); p. 214 - 220, View in Reaxys

Maxima

ethanol

300 nm

Kurechi; Kikugawa; Aoshima; Chemical and Pharmaceutical Bulletin; vol. 29; nb. 8; (1981); p. 2351 - 2358, View in Reaxys

Maxima

H2O

335 nm

Kurechi; Kikugawa; Aoshima; Chemical and Pharmaceutical Bulletin; vol. 29; nb. 8; (1981); p. 2351 - 2358, View in Reaxys

Phosphorescence Spectroscopy (1) Description References (Phosphorescence Spectroscopy) Triplet state decay kinetics

Joshi, Ravi; Kapoor; Mukherjee; Journal of Physical Organic Chemistry; vol. 20; nb. 3; (2007); p. 214 220, View in Reaxys

Use (13) Laboratory Use and Handling

Use Pattern

References

as nematicide oil Patent; Baseeth, Shireen; US2008/175930; (2008); (A1) English, View in Reaxys for composition comprising lecithin and co-surfactant for controlling nematodes in soil and pests in grasses and lawns Antioxidant

Patent; Suntory Limited; US2006/88573; (2006); (A1) English, View in Reaxys; Patent; AMOREPACIFIC CORPORATION; WO2006/132479; (2006); (A1) English, View in Reaxys

anti-oxidant

Patent; INSYS THERAPEUTICS, INC.; WO2006/63109; (2006); (A2) English, View in Reaxys

Synergistic com- Patent; ENDURA S.P.A.; WO2006/111553; (2006); (A1) English, View in Reaxys ponent for insecticidal formulations Synergistic com- Patent; ENDURA S.P.A.; WO2006/111570; (2006); (A2) English, View in Reaxys ponent of biologically active formulations Synergistic compound for preparation of insecticidal compositions

Patent; CHEMIA S.P.A.; WO2006/111839; (2006); (A1) English, View in Reaxys

Synergistic compound with active substance in insecticide formulation

Patent; ENDURA S.P.A.; WO2005/39287; (2005); (A2) English, View in Reaxys

Synergistic compound with active substance in insecticide formulation for veterinary use

Patent; ENDURA S.P.A.; WO2005/39287; (2005); (A2) English, View in Reaxys

Synergistic compound with active substance in insecticide formulation to eleiminate household insect

Patent; ENDURA S.P.A.; WO2005/39287; (2005); (A2) English, View in Reaxys

coupler for cosPatent; Lagrange, Alain; US2005/278872; (2005); (A1) English, View in Reaxys metic composition

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for dyeing keratin fibres Oxidation dye for hair or make-up cosmetic composition

Patent; Mathonneau, Estelle; Rollat, Isabelle; Giroud, Franck; US2005/186165; (2005); (A1) English, View in Reaxys

antioxidation effect on the autoxidation of γ-irradiated methyl linoleate

Kitahara; Matsumoto; Ueda; Ueoka; Chemical and Pharmaceutical Bulletin; vol. 40; nb. 8; (1992); p. 2208 - 2209, View in Reaxys

antioxidant

Kurechi, Tsutao; Kikugawa, Kiyomi; Kato, Tetsuta; Chemical & Pharmaceutical Bulletin; vol. 28; nb. 7; (1980); p. 2089 - 2093, View in Reaxys

Quantum Chemical Calculations (2) Calculated Prop- Method (Quantum References erties Chemical Calculations) Dissociation ener- Ab initio calcns. gy, bonding ener- (LCAO, GO SCF, gy DIM, SAMO, X-à, Hartree-Fock)

Rodriguez, Sergio A.; Nazareno, Monica A.; Baumgartner, Maria T.; Australian Journal of Chemistry; vol. 66; nb. 11; (2013); p. 1334 - 1341, View in Reaxys; Guitard, Romain; Paul, Jean-François; Nardello-Rataj, Véronique; Aubry, Jean-Marie; Food Chemistry; vol. 213; (2016); p. 284 - 295, View in Reaxys

Ionization poten- Ab initio calcns. tial, orbital energy (LCAO, GO SCF, DIM, SAMO, X-à, Hartree-Fock)

Indo, Hiroko P.; Nakanishi, Ikuo; Ohkubo, Kei; Yen, Hsiu-Chuan; Nyui, Minako; Manda, Sushma; Matsumoto, Ken-Ichiro; Fukuhara, Kiyoshi; Anzai, Kazunori; Ikota, Nobuo; Matsui, Hirofumi; Minamiyama, Yukiko; Nakajima, Akira; Ichikawa, Hiroshi; Fukuzumi, Shunichi; Ozawa, Toshihiko; Mukai, Chiaki; Majima, Hideyuki J.; RSC Advances; vol. 3; nb. 14; (2013); p. 4535 - 4538, View in Reaxys

Medchem (191) 1 of 191

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |protein binding Target : human erythrocytes membranesBioassay : control: without title comp.; aggregates were subjected to SDS polyacrylamide gel electrophoresis (SDS-PAGE) membranes (1.5 mg/ml) were incubated with various conc. of title comp. at 37 deg C for 1 h under aerobic condition; C12E8-insoluble protein aggregates and protein contents was determined by the method of Lowry; band 3 protein was detected

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

0.500000 mM

Qualitative Results

title comp. dose-dependently increased C12E8-insoluble protein aggregates and amounts of bind 3 protein in aggregates (diagram)

Measurement Parameter

Qualitative

Ando, Ken; Sako, Ken-Ichi; Takahashi, Makoto; Beppu, Masatoshi; Kikugawa, Kiyomi; Biological and Pharmaceutical Bulletin; vol. 23; nb. 2; (2000); p. 159 - 164, View in Reaxys 2 of 191

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |protein binding Target : human erythrocytes membranesBioassay : control: without title comp.; aggregates were subjected to SDS polyacrylamide gel electrophoresis (SDS-PAGE); Western-blotting using rabbit anti-band 3 IgG erythrocytes membranes (3 mg/ml, 3 ml) were incubated with title comp. in various conc. at 37 deg C for 1 h under aerobic or anaerobic conditions; C12E8-insoluble protein aggregates determined; protein contents was determined by the method of Lowry

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

10 mM

Qualitative Results

title comp. increased C12E8-insoluble protein aggregates and bind 3 protein mostly in aerobic condition (diagram)

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Measurement Parameter

Qualitative

Ando, Ken; Sako, Ken-Ichi; Takahashi, Makoto; Beppu, Masatoshi; Kikugawa, Kiyomi; Biological and Pharmaceutical Bulletin; vol. 23; nb. 2; (2000); p. 159 - 164, View in Reaxys 3 of 191

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |protein binding Bioassay : control: without title comp.; aggregates were subjected to SDS polyacrylamide gel electrophoresis (SDS-PAGE) erythrocytes (3 mg protein/ml) mixed with title comp. in various conc.; incubation at 37 deg C for 1 h; C12E8-insoluble aggregates isolated from membrane and protein was determined by the method of Lowry; band 3 protein detection

Biological Species/NCBI Human ID Cells/Cell Lines

erythrocyte

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

0.500000 mM

Qualitative Results

title comp. dose-dependently increased nonionic detergent C12E8-insoluble membrane proteins and band 3 protein (diagrams)

Measurement Parameter

Qualitative

Ando, Ken; Sako, Ken-Ichi; Takahashi, Makoto; Beppu, Masatoshi; Kikugawa, Kiyomi; Biological and Pharmaceutical Bulletin; vol. 23; nb. 2; (2000); p. 159 - 164, View in Reaxys 4 of 191

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |protein binding Bioassay : control: without title comp. erythrocytes mixed with title comp. in various conc. and incubated at 37 deg C for 1 h; incubation with autologous IgG at 4 deg C overnigt; amount of cell-bound IgG was measured by enzyme immunoassay using a protein A-β-galactozidase conjugate

Biological Species/NCBI Human ID Cells/Cell Lines

erythrocyte

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

5 mM

Qualitative Results

title comp. dose-dependently increased binding of erythrocytes with IgG (diagram)

Measurement Parameter

Qualitative

Ando, Ken; Sako, Ken-Ichi; Takahashi, Makoto; Beppu, Masatoshi; Kikugawa, Kiyomi; Biological and Pharmaceutical Bulletin; vol. 23; nb. 2; (2000); p. 159 - 164, View in Reaxys 5 of 191

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |protein binding Bioassay : control: without title comp. erythrocytes mixed with title comp. in various conc. and incubated at 37 deg C for 1 h; incubation with 125I-labeled anti-band 3 IgG at 4 deg C overnigt; cell-bound radioactivity measured by gamma counter

Biological Species/NCBI Human ID Cells/Cell Lines

erythrocyte

Substance RN

127405View in Reaxys

Substance Name

173628

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Substance Dose

5 mM

Qualitative Results

title comp. dose-dependently increased binding of anti-band 3 IgG (diagram)

Measurement Parameter

Qualitative

Ando, Ken; Sako, Ken-Ichi; Takahashi, Makoto; Beppu, Masatoshi; Kikugawa, Kiyomi; Biological and Pharmaceutical Bulletin; vol. 23; nb. 2; (2000); p. 159 - 164, View in Reaxys 6 of 191

Substance Effect

Cytotoxic

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Bioassay : control: without title comp.; MetHb was measured after hypotonic hemolisis spectrophotometrically at 630 nm; membrane-bound protein was measured by pyridine hemochromogen method erythrocytes (3 mg protein/ml) mixed with title comp. in various conc.; incubation at 37 deg C for 1 h; cytoplasmic MetHb and the amount of membranebound hemoglobins were measured

Biological Species/NCBI Human ID Cells/Cell Lines

erythrocyte

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

0.500000 mM

Qualitative Results

title comp. dose-dependently increased membrane-bound hemoglobin and MetHb content in erythrocytes cytosole (100 percent of MetHb in title comp. conc. 5 mmol/l) (table)

Measurement Parameter

Qualitative

Ando, Ken; Sako, Ken-Ichi; Takahashi, Makoto; Beppu, Masatoshi; Kikugawa, Kiyomi; Biological and Pharmaceutical Bulletin; vol. 23; nb. 2; (2000); p. 159 - 164, View in Reaxys 7 of 191

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Substance RN

127405View in Reaxys

Substance Name

173628

Qualitative Results

antioxidant activity against Fe2+-induced lipid oxidation, IC50 = 18.5 μM

Measurement Parameter

Qualitative

Chen; Ahn; JAOCS, Journal of the American Oil Chemists' Society; vol. 75; nb. 12; (1998); p. 1717 - 1721, View in Reaxys 8 of 191

Target Mutant/Chimera Details

Ecdysone receptor:Wild; Retinoic acid receptor RXR-alpha [Mus musculus]:Wild; bile acid receptor:Wild

Substance Action on Target

Agonist

Target Species (Bioactivity)

Mus musculus

Target Subunit Proteins

Ecdysone receptor; Retinoic acid receptor RXR-alpha [Mus musculus]; bile acid receptor

Target Transfection

Transfected; Transfected; Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Transactivation assay

Cells/Cell Lines

CHO

Substance RN

127405View in Reaxys

Substance Name

sesamol

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Measurement Parameter

Fold-increase

Quantitative value

Target, Subunit, Species Ecdysone receptor; Retinoic acid receptor RXR-alpha [Mus musculus]; bile acid receptor

9 of 191

Target Subunit Synonyms

20-hydroxy-ecdysone receptor (ecdysone receptor); 20e receptor; aaecr; aael009600; ecdysone receptor; ecdysteroid receptor (ecdysone receptor); ecr (ecdysone receptor); ecrh (ecdysone receptor); hvecr; nr1h1 (ecdysone receptor); nuclear receptor subfamily 1 group h member 1 (ecdysone receptor); nr2b1; nuclear receptor subfamily 2 group b member 1; retinoic acid receptor rxr-alpha; retinoid x receptor alpha; rxra; bar (bile acid receptor); bile acid receptor; farnesoid x-activated receptor; farnesol receptor hrr-1; fxr (bile acid receptor); hrr1 (bile acid receptor); nr1h4; nuclear receptor subfamily 1 group h member 4; retinoid x receptor-interacting protein 14; rip14; rxr-interacting protein 14

Target Uniprot ID

p28700

Target PDB ID

1dkf; 1xdk; 3a9e

Substance Effect

Antidote

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Target : Chasmagnathus granulatus, estuarine crabBioassay : control: filtered salt water at 20ppt salinity; CAT: catalase; GST: glutathione-S-transferase; LPO: lipid peroxidation crabs injected with title comp. twice; injected with methyl parathion or filtered salt water for 3 d; hepatopancreas collected; hispathologies determ.; CAT and GST activities determ. spectrophotometrically; LPO levels determ. using FOX-assay

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

0.850000 mg/kg

Qualitative Results

title comp. significantly protected hepatopancreas against methyl parathion from tubule damage, increase in CAT and GST activities and increase in LPO levels; figures

Measurement Parameter

Qualitative

Bianchini, Adalto; Monserrat, Jose Maria; Ecotoxicology and Environmental Safety; vol. 67; nb. 1; (2007); p. 100 108, View in Reaxys 10 of 191

Substance Effect

Antioxidant

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Target : Albino Charles-Foster rat brain homogenateBioassay : effect on cumene hydroperoxide-induced lipid peroxidation evaluated using thiobarbituric acid reactive substances assay; 100 μmol/l CuOOH; 37 deg C; incubated for 20 min

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

90 µM

Qualitative Results

title comp. inhibited cumene hydroperoxide-induced lipid peroxidation by 57.87 percent

Measurement Parameter

Qualitative

Joshi, Ravi; Kumar, M. Sudheer; Satyamoorthy; Unnikrisnan; Mukherjee, Tulsi; Journal of Agricultural and Food Chemistry; vol. 53; nb. 7; (2005); p. 2696 - 2703, View in Reaxys 11 of 191

Substance Effect

Antioxidant

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Target : Albino Charles-Foster rat brain homogenateBioassay : effect on Fe(III)-induced lipid peroxidation evaluated using thiobarbituric acid reactive substances assay; 200 μmol/l FeCl3; 37 deg C; incubated for 20 min

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Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

7.50000 µM

Qualitative Results

at 7.5/10/15/30/60/90 μmol/l title comp. inhibited Fe(III)-induced lipid peroxidation by 11.7/14.0/23.9/31.3/59.49/99.3 percent

Measurement Parameter

Qualitative

Joshi, Ravi; Kumar, M. Sudheer; Satyamoorthy; Unnikrisnan; Mukherjee, Tulsi; Journal of Agricultural and Food Chemistry; vol. 53; nb. 7; (2005); p. 2696 - 2703, View in Reaxys 12 of 191

Substance Effect

Antioxidant

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Target : Albino Charles-Foster rat brain homogenateBioassay : effect on Fe(II)-induced lipid peroxidation evaluated using thiobarbituric acid reactive substances assay; 200 μmol/l FeSO4; 37 deg C; incubated for 20 min

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

90 µM

Qualitative Results

title comp. inhibited Fe(II)-induced lipid peroxidation by 69.91 percent

Measurement Parameter

Qualitative

Joshi, Ravi; Kumar, M. Sudheer; Satyamoorthy; Unnikrisnan; Mukherjee, Tulsi; Journal of Agricultural and Food Chemistry; vol. 53; nb. 7; (2005); p. 2696 - 2703, View in Reaxys 13 of 191

Substance Effect

Antioxidant

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Target : PGEM-7ZF plasmid DNABioassay : DNA nicking assay; 30 mmol/l H2O2; 16 mmol/l FeSO4; 30 mmol/l EDTA; assay buffer, pH 7.4; 37 deg C; incubated for 1 h; amounts of supercoiled and nicked circular DNA determined by agarose gel analysis

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

0.500000 mM

Qualitative Results

at 0.5 mmol/l title comp. failed to prevent nonsite specific OH radical-induced oxidative damage to DNA but at 1.5 and 2.5 mmol/l protected DNA in supercoiled and nicked circular forms without allowing complete breakage to degraded form by Fenton agents

Measurement Parameter

Qualitative

Joshi, Ravi; Kumar, M. Sudheer; Satyamoorthy; Unnikrisnan; Mukherjee, Tulsi; Journal of Agricultural and Food Chemistry; vol. 53; nb. 7; (2005); p. 2696 - 2703, View in Reaxys 14 of 191

Substance Effect

Antioxidant

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : scavenging activityBioassay : DPPH radicalDPPH: 2,2-diphenyl-1-picrylhydrazyl

Substance RN

127405View in Reaxys

Substance Name

173628

Qualitative Results

ARP anti-radical power 5.5

Measurement Parameter

Qualitative

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Arteaga, Jesus F; Ruiz-Montoya, Mercedes; Palma, Alberto; Alonso-Garrido, Gema; Pintado, Sara; Rodriguez-Mellado, Jose M; Molecules (Basel, Switzerland); vol. 17; nb. 5; (2012); p. 5126 - 5138, View in Reaxys 15 of 191

Substance Effect

Carcinogenic

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : carcinogenicityBioassay : animal

Substance RN

127405View in Reaxys

Substance Name

173628

Qualitative Results

TD50 -0.990

Measurement Parameter

Qualitative

Toropov; Toropova; Benfenati; European Journal of Medicinal Chemistry; vol. 45; nb. 9; (2010); p. 3581 - 3587, View in Reaxys 16 of 191

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : hydroxyl radical scavengerTarget : supercoiled plasmid pBR 322 DNABioassay : in vitro; effect on hydroxyl radical-induced DNA single-strand breaks assayed; sodium phosphate buffer, pH 7.4; 0.1 mM H2O2; 0.1 mM FeSO4; 37 deg C; incub. for 1 h; agarose gel electrophoresis; band visualized by irradiation at 300 nm

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

1 µM

Qualitative Results

title comp. inhibited single-strand breaks induced by hydroxyl radical dose-dependently

Measurement Parameter

Qualitative

Hiramoto, Kazuyuki; Ojima, Natsuko; Sako, Ken-Ichi; Kikugawa, Kiyomi; Biological and Pharmaceutical Bulletin; vol. 19; nb. 4; (1996); p. 558 - 563, View in Reaxys 17 of 191

Substance Effect

Genotoxic

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Target : supercoiled plasmid pBR 322 DNABioassay : in vitro; effect on DNA single-strand breaks assayed; sodium phosphate buffer, pH 7.4; 0.1 mM H2O2 or 0.1 mM FeSO4; 37 deg C; incub. for 1 h; agarose gel electrophoresis; band visualized by irradiation at 300 nm

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

1 µM

Measurement Parameter

Qualitative

Qualitative value

Hiramoto, Kazuyuki; Ojima, Natsuko; Sako, Ken-Ichi; Kikugawa, Kiyomi; Biological and Pharmaceutical Bulletin; vol. 19; nb. 4; (1996); p. 558 - 563, View in Reaxys 18 of 191

Substance Effect

Radioprotective

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Bioassay : controls: sham and radiation control mice treated with title comp., 30 min prior to 15 Gy whole-body γ-irradiation; jejunum was removed 72 h post-irradiation; sections prepared and histopathological studies performed

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Biological Species/NCBI Mus musculus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

50 mg/kg

Substance Route of Adm.

intraperitoneal administration

Qualitative Results

title comp. pretreatment (50 mg/kg) kept villus height close to normal, whereas no signif. change was obsd. in mitotic/goblet/dead cells; 100 mg/kg was not effective in maintaining villus height but number of inflammatory and dead cells were less; fig.

Measurement Parameter

Qualitative

Substance Effect

Radioprotective

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Bioassay : controls: sham and radiation control mice treated with title comp., 30 min prior to 4.5 Gy whole-body γ-irradiation; sacrificed at intervals of 0.5-8 h post-irradiation; liver removed; homogenized; endogenous antioxidant enzymes determined

Biological Species/NCBI Mus musculus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

25 mg/kg

Substance Route of Adm.

intraperitoneal administration

Qualitative Results

radiation-induced decrease in antioxidant enzymes (glutathione, glutathione-S-transferase, catalase) was reduced by pretreatment with title comp. at all monitored post-irradiation intervals; fig.

Measurement Parameter

Qualitative

Substance Effect

Radioprotective

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Biological Species/NCBI Mus musculus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

25 mg/kg

Substance Route of Adm.

intraperitoneal administration

Qualitative Results

radiation-induced increase in lipid peroxidation was reduced by pretreatment with title comp. at all monitored post-irradiation intervals; fig.

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Measurement Parameter

Qualitative

Substance Effect

Radioprotective

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Bioassay : controls: sham and radiation control mice treated with title comp., 30 min prior to 9.5 Gy whole-body γ-irradiation; after irradiation, body weight monitored daily for a period of 30 days

Biological Species/NCBI Mus musculus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

10 mg/kg

Substance Route of Adm.

intraperitoneal administration

Qualitative Results

title comp. pretreatment with 50 mg/kg effectively prevented the reduction in body weight

Measurement Parameter

Qualitative

Substance Effect

Radioprotective

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Bioassay : controls: sham and radiation control mice treated with title comp., 30 min prior to 9.5 Gy whole-body γ-irradiation; after irradiation, monitored daily for a period of 30 days for any symptoms of radiation sickness and mortality

Biological Species/NCBI Mus musculus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

10 mg/kg

Substance Route of Adm.

intraperitoneal administration

Qualitative Results

pretreatment with title comp. at 40 mg/kg resulted in survival of 5/10 animals at 30 days post-irradiation; highest % survival (7/10) was obsd. at 50 mg/kg when compared to radiation control; linear dose-response obsd. between 25 and 50 mg/kg; fig.

Measurement Parameter

Qualitative

Substance Effect

Radioprotective

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Bioassay : controls: sham and radiation control; spleen index was calculated by dividing spleen weight by body weight and multiplying by a factor of 100 mice treated with title comp., 30 min prior to 11 Gy whole-body γ-irradiation; on 11th day post-irradiation, sacri-

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ficed; spleen removed and spleen index was calculated; spleen colony-forming units (CFU) were counted manually Biological Species/NCBI Mus musculus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

50 mg/kg

Substance Route of Adm.

intraperitoneal administration

Qualitative Results

pretreatment with 50 and 100 mg/kg title comp. maintained spleen index close to shamcontrol; both doses were found effective in initiating CFU formation, with a score of 4.65 and 4.87, resp.; table

Measurement Parameter

Qualitative

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Bioassay Details

Species : Sprague-Dawley rat

Biological Species/NCBI Rattus norvegicus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

Measurement Parameter

Cmax

Unit

nmol/mL

Quantitative value

20.1

Hou, Yu-Chi; Tsai, Shang-Yuan; Liu, I.-Ling; Yu, Chung-Ping; Chao, Pei-Dawn Lee; Journal of Agricultural and Food Chemistry; vol. 56; nb. 20; (2008); p. 9636 - 9640, View in Reaxys 25 of 191

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Bioassay Details

Species : Sprague-Dawley rat

Biological Species/NCBI Rattus norvegicus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

10 mg/kg

Substance Route of Adm.

intravenous administration

Measurement Parameter

Cmax

Unit

nmol/mL

Quantitative value

86.4

Hou, Yu-Chi; Tsai, Shang-Yuan; Liu, I.-Ling; Yu, Chung-Ping; Chao, Pei-Dawn Lee; Journal of Agricultural and Food Chemistry; vol. 56; nb. 20; (2008); p. 9636 - 9640, View in Reaxys

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26 of 191

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Bioassay Details

Species : Sprague-Dawley rat

Biological Species/NCBI Rattus norvegicus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

Measurement Parameter

Tmax

Unit

minute

Quantitative value

9.2

Hou, Yu-Chi; Tsai, Shang-Yuan; Liu, I.-Ling; Yu, Chung-Ping; Chao, Pei-Dawn Lee; Journal of Agricultural and Food Chemistry; vol. 56; nb. 20; (2008); p. 9636 - 9640, View in Reaxys 27 of 191

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Bioassay Details

Species : Sprague-Dawley rat

Biological Species/NCBI Rattus norvegicus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

10 mg/kg

Substance Route of Adm.

intravenous administration

Measurement Parameter

AUC

Unit

nmol.min/L

Quantitative value

1540.3

Hou, Yu-Chi; Tsai, Shang-Yuan; Liu, I.-Ling; Yu, Chung-Ping; Chao, Pei-Dawn Lee; Journal of Agricultural and Food Chemistry; vol. 56; nb. 20; (2008); p. 9636 - 9640, View in Reaxys 28 of 191

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Bioassay Details

Species : Sprague-Dawley rat

Biological Species/NCBI Rattus norvegicus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

Measurement Parameter

AUC

Unit

nmol.min/L

Quantitative value

3160.3

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Hou, Yu-Chi; Tsai, Shang-Yuan; Liu, I.-Ling; Yu, Chung-Ping; Chao, Pei-Dawn Lee; Journal of Agricultural and Food Chemistry; vol. 56; nb. 20; (2008); p. 9636 - 9640, View in Reaxys 29 of 191

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Bioassay Details

Species : Sprague-Dawley rat

Biological Species/NCBI Rattus norvegicus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

10 mg/kg

Substance Route of Adm.

intravenous administration

Measurement Parameter

MRT

Unit

minute

Quantitative value

13.9

Hou, Yu-Chi; Tsai, Shang-Yuan; Liu, I.-Ling; Yu, Chung-Ping; Chao, Pei-Dawn Lee; Journal of Agricultural and Food Chemistry; vol. 56; nb. 20; (2008); p. 9636 - 9640, View in Reaxys 30 of 191

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Bioassay Details

Species : Sprague-Dawley rat

Biological Species/NCBI Rattus norvegicus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

Measurement Parameter

MRT

Unit

minute

Quantitative value

15.2

Hou, Yu-Chi; Tsai, Shang-Yuan; Liu, I.-Ling; Yu, Chung-Ping; Chao, Pei-Dawn Lee; Journal of Agricultural and Food Chemistry; vol. 56; nb. 20; (2008); p. 9636 - 9640, View in Reaxys 31 of 191

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Biochemistry: Others

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Unit

Quantitative value

19.4

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Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

32 of 191

Measurement Object

palmitic acid

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Biochemistry: Others

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Unit

Quantitative value

18.6

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

33 of 191

Measurement Object

stearic acid

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Biochemistry: Others

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Unit

Quantitative value

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

34 of 191

Measurement Object

oleic acid

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Biochemistry: Others

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Unit

30/88

2017-10-14 23:10:10

Quantitative value

2.4

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

35 of 191

Measurement Object

vaccenic acid

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Biochemistry: Others

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Unit

Quantitative value

13.2

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

36 of 191

Measurement Object

linolenic acid

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Biochemistry: Others

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Unit

Quantitative value

1.4

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

37 of 191

Measurement Object

DGLA

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Biochemistry: Others

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

31/88

2017-10-14 23:10:10

Unit

Quantitative value

25.7

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

38 of 191

Measurement Object

arachidonic acid

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Biochemistry: Others

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Unit

Quantitative value

2.5

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

39 of 191

Measurement Object

docosapentaenoic acid

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Biochemistry: Others

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Unit

Quantitative value

9.7

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

40 of 191

Measurement Object

docosahexaenoic acid

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Biochemistry: Others

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men

32/88

2017-10-14 23:10:10

Measurement Parameter

Unit

Quantitative value

19.5

Deviation

1.40000

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

41 of 191

Measurement Object

palmitic acid

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Biochemistry: Others

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Unit

Quantitative value

19.2

Deviation

1.70000

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

42 of 191

Measurement Object

stearic acid

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Biochemistry: Others

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Unit

Quantitative value

8.2

Deviation

1.10000

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

43 of 191

Measurement Object

oleic acid

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Biochemistry: Others

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

33/88

2017-10-14 23:10:10

Substance Name

sesamol

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Unit

Quantitative value

2.6

Deviation

0.400000

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

44 of 191

Measurement Object

vaccenic acid

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Biochemistry: Others

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Unit

Quantitative value

13.6

Deviation

0.700000

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

45 of 191

Measurement Object

linolenic acid

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Biochemistry: Others

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Unit

Quantitative value

1.6

Deviation

0.100000

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

46 of 191

Measurement Object

DGLA

Bioassay Category

In Vivo (Animal models)

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Bioassay Name

Biochemistry: Others

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Unit

Quantitative value

24.9

Deviation

0.900000

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

47 of 191

Measurement Object

arachidonic acid

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Biochemistry: Others

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Unit

Quantitative value

1.4

Deviation

0.100000

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

48 of 191

Measurement Object

docosapentaenoic acid

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Biochemistry: Others

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Unit

Quantitative value

9.5

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Deviation

0.400000

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

49 of 191

Measurement Object

docosahexaenoic acid

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Concentration

Unit

pg/mL

Quantitative value

2931

Deviation

461

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

50 of 191

Measurement Object

TNF-alpha

Compound RN

8187061

Compound name

Lipopolysaccharide

Compound role

IAV

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Concentration

Unit

ng/mL

Quantitative value

Deviation

Statistical sgnificance (Qualitative)

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys Measurement Object

IL-6

Compound RN

8187061

Compound name

Lipopolysaccharide

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51 of 191

Compound role

IAV

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Concentration

Unit

pg/mL

Quantitative value

236

Deviation

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

52 of 191

Measurement Object

IL-10

Compound RN

8187061

Compound name

Lipopolysaccharide

Compound role

IAV

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Biological Species/NCBI Bagg albino mouse ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Concentration

Unit

pg/mL

Quantitative value

6620

Deviation

646

Patent; Forse, R. Armour; Chavali, Sambasiva R.; US6172106; (2001); (B2) English, View in Reaxys

53 of 191

Measurement Object

IL-12

Compound RN

8187061

Compound name

Lipopolysaccharide

Compound role

IAV

Substance Effect

Antioxidant

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

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Bioassay Details

Target : keratinocytes (HaCat) of humanBioassay : Measurement of antioxidant effectHuman keratinocytes (HaCat) were plated at a density of 1.0 x 106 per EPO <DP n="15"/ >60-mm dish and then cultured in penicillin/streptomycin-containing DMEM (10% FBS) media at conditions of 37 0C and 5% CO2 for 1 week. Then, the culture

Substance RN

127405View in Reaxys

Substance Name

173628

Qualitative Results

relative results given: untreated group 100, t-BHP (tert-butyl hydroperoxide) 320, title compound 250

Measurement Parameter

Qualitative

Patent; YOU, Jae Won; RHO, Ho Sik; KIM, Duck Hee; CHANG, Ih Seop; LEE, Ok Sub; (25 pag.); WO2006/132479; (A1); (2006), View in Reaxys 54 of 191

Substance Effect

Antiaging

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Bioassay : Measurement of anti-aging effect Fibroblasts were seeded into each well of a 24-well plate at density of106 cells and cultured to 90% confluence. The cultured cells were cultured in serum-free media for 24 hours and then treated with 10"4 M of each of tocopherol, sesamol and the

Cells/Cell Lines

Fibroblast

Substance RN

127405View in Reaxys

Substance Name

173628

Qualitative Results

procollagen synthesis 103 % relative to untreated control (100 %)

Measurement Parameter

Qualitative

Patent; YOU, Jae Won; RHO, Ho Sik; KIM, Duck Hee; CHANG, Ih Seop; LEE, Ok Sub; (25 pag.); WO2006/132479; (A1); (2006), View in Reaxys 55 of 191

Substance Effect

Anticarcinogenic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Target : F344/DuCrj ratBioassay : numbers and areas of preneoplastic glutathione Stransferase placental form-positive (GST-P+) foci and tumor growth factor α-positive (TGFα+) foci were measured; histopathologic slides were evaluated for diagnosis of hepatocellular neoplasms 2 year feeding study conducted with diet containing 2 percent title comp. to 6 weeks old rats; final body weight and liver weight were noted; formalin-fixed and parafin-embedded liver tissues were cut and stained for GST-P and TGFα immunohistochemically

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Route of Adm.

oral administration

Qualitative Results

treated/control proportional values for average numbers and areas of GST-P+ foci were 58 and 54 percent, respectively; no incidence of neoplastic lesions in livers and no intergroup differences for TGFα+ foci were detected

Measurement Parameter

Qualitative

Hagiwara; Kokubo; Takesada; Tanaka; Tamano; Hirose; Shirai; Ito; Teratogenesis Carcinogenesis and Mutagenesis; vol. 16; nb. 6; (1996); p. 317 - 325, View in Reaxys 56 of 191

Substance Effect

Antimutagenic

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

38/88

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Bioassay Details

Effect : number of His+ revertantsBioassay : antimutagenic activity of title comp. against H2O2 (100 μg/plate)-induced mutagenicity was studied using standard Ames test

Biological Species/NCBI Salmonella enterica subsp. enterica serovar Typhimurium ID Substance RN

127405View in Reaxys

Substance Name

173628

Qualitative Results

sign. dose-dependent inhib. of NaN3-induced mutagenicity, diagram representation

Measurement Parameter

Qualitative

Kaur, Indu Pal; Saini, Amarpreet; Mutation Research - Genetic Toxicology and Environmental Mutagenesis; vol. 470; nb. 1; (2000); p. 71 - 76, View in Reaxys 57 of 191

Substance Effect

Antimutagenic

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : number of His+ revertantsBioassay : antimutagenic activity of title comp. against NaN3 (0.5 μg/plate)-induced mutagenicity was studied using standard Ames test

Biological Species/NCBI Salmonella enterica subsp. enterica serovar Typhimurium ID Substance RN

127405View in Reaxys

Substance Name

173628

Qualitative Results

sign. dose-dependent inhib. of NaN3-induced mutagenicity, diagram representation

Measurement Parameter

Qualitative

Kaur, Indu Pal; Saini, Amarpreet; Mutation Research - Genetic Toxicology and Environmental Mutagenesis; vol. 470; nb. 1; (2000); p. 71 - 76, View in Reaxys 58 of 191

Substance Effect

Antimutagenic

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : number of His+ revertantsBioassay : nitroquinoline-N-oxide (NQNO) antimutagenic activity of title comp. against NQNO-induced mutagenicity was studied using standard Ames test

Biological Species/NCBI Salmonella enterica subsp. enterica serovar Typhimurium ID Substance RN

127405View in Reaxys

Substance Name

173628

Measurement Parameter

Qualitative

Qualitative value

Kaur, Indu Pal; Saini, Amarpreet; Mutation Research - Genetic Toxicology and Environmental Mutagenesis; vol. 470; nb. 1; (2000); p. 71 - 76, View in Reaxys 59 of 191

Substance Effect

Antimutagenic

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : number of His+ revertantsBioassay : tert-butylhydroperoxide (t-BOOH) antimutagenic activity of title comp. against t-BOOH (200 μg/plate)-induced mutagenicity was studied using standard Ames test

Biological Species/NCBI Salmonella enterica subsp. enterica serovar Typhimurium ID Substance RN

127405View in Reaxys

39/88

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Substance Name

173628

Measurement Parameter

ID50

Unit

µmol

Qualitative value

Quantitative value

Kaur, Indu Pal; Saini, Amarpreet; Mutation Research - Genetic Toxicology and Environmental Mutagenesis; vol. 470; nb. 1; (2000); p. 71 - 76, View in Reaxys 60 of 191

Substance Effect

Antimutagenic

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : number of His+ revertantsTarget : Salmonella typhimurium TA102Bioassay : antimutagenic activity of title comp. against H2O2 (100 μg/plate)-induced mutagenicity was studied using standard Ames test

Substance RN

127405View in Reaxys

Substance Name

173628

Qualitative Results

sign. dose-dependent inhib. of NaN3-induced mutagenicity, diagram representation

Measurement Parameter

Qualitative

Kaur, Indu Pal; Saini, Amarpreet; Mutation Research - Genetic Toxicology and Environmental Mutagenesis; vol. 470; nb. 1; (2000); p. 71 - 76, View in Reaxys 61 of 191

Substance Effect

Antimutagenic

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : number of His+ revertantsTarget : Salmonella typhimurium TA102Bioassay : tertbutylhydroperoxide (TBP) antimutagenic activity of title comp. against TBP (100 μg/plate)induced mutagenicity was studied using standard Ames test; test culture preincub. with (1) title comp. or (2) TBP for 20 min, or (3) title comp. and TBP were added simultaneously

Substance RN

127405View in Reaxys

Substance Name

173628

Qualitative Results

maximium antimutagenic activity of title comp. against TBP-induced mutagenicity was obs. in the case (1) of preincubation of test culture with title comp. and the minimum one in the case (2) of title comp. addition after t-BOOH

Measurement Parameter

Qualitative

Kaur, Indu Pal; Saini, Amarpreet; Mutation Research - Genetic Toxicology and Environmental Mutagenesis; vol. 470; nb. 1; (2000); p. 71 - 76, View in Reaxys 62 of 191

Substance Effect

Antimutagenic

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : number of His+ revertantsTarget : Salmonella typhimurium TA102Bioassay : tertbutylhydroperoxide (t-BOOH) antimutagenic activity of title comp. against t-BOOH-induced (50, 75, 100, and 125 μg/plate) mutagenicity was studied using standard Ames test

Substance RN

127405View in Reaxys

Substance Name

173628

Measurement Parameter

ID50

Unit

µmol

Quantitative value

0.6

40/88

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Kaur, Indu Pal; Saini, Amarpreet; Mutation Research - Genetic Toxicology and Environmental Mutagenesis; vol. 470; nb. 1; (2000); p. 71 - 76, View in Reaxys 63 of 191

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Bioassay Details

Species : Sprague-Dawley rat

Biological Species/NCBI Rattus norvegicus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

Measurement Parameter

F(%)

Unit

Quantitative value

35.5

Jan, Kuo-Ching; Ho, Chi-Tang; Hwang, Lucy Sun; Journal of Agricultural and Food Chemistry; vol. 56; nb. 16; (2008); p. 7032 - 7037, View in Reaxys 64 of 191

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Bioassay Details

Species : Sprague-Dawley rat

Biological Species/NCBI Rattus norvegicus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

Measurement Parameter

Cmax

Unit

µg/mL

Quantitative value

1.4

Jan, Kuo-Ching; Ho, Chi-Tang; Hwang, Lucy Sun; Journal of Agricultural and Food Chemistry; vol. 56; nb. 16; (2008); p. 7032 - 7037, View in Reaxys 65 of 191

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Bioassay Details

Species : Sprague-Dawley rat

Biological Species/NCBI Rattus norvegicus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

5 mg/kg

Substance Route of Adm.

intravenous administration

Measurement Parameter

Cmax

Unit

µg/mL

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Quantitative value

2.3

Jan, Kuo-Ching; Ho, Chi-Tang; Hwang, Lucy Sun; Journal of Agricultural and Food Chemistry; vol. 56; nb. 16; (2008); p. 7032 - 7037, View in Reaxys 66 of 191

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Bioassay Details

Species : Sprague-Dawley rat

Biological Species/NCBI Rattus norvegicus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

Measurement Parameter

Tmax

Unit

minute

Quantitative value

2.5

Jan, Kuo-Ching; Ho, Chi-Tang; Hwang, Lucy Sun; Journal of Agricultural and Food Chemistry; vol. 56; nb. 16; (2008); p. 7032 - 7037, View in Reaxys 67 of 191

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Bioassay Details

Species : Sprague-Dawley rat

Biological Species/NCBI Rattus norvegicus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

5 mg/kg

Substance Route of Adm.

intravenous administration

Measurement Parameter

t1/2

Unit

minute

Quantitative value

29.2

Jan, Kuo-Ching; Ho, Chi-Tang; Hwang, Lucy Sun; Journal of Agricultural and Food Chemistry; vol. 56; nb. 16; (2008); p. 7032 - 7037, View in Reaxys 68 of 191

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Bioassay Details

Species : Sprague-Dawley rat

Biological Species/NCBI Rattus norvegicus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

Measurement Parameter

t1/2

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Unit

minute

Quantitative value

563.7

Jan, Kuo-Ching; Ho, Chi-Tang; Hwang, Lucy Sun; Journal of Agricultural and Food Chemistry; vol. 56; nb. 16; (2008); p. 7032 - 7037, View in Reaxys 69 of 191

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Species : Sprague-Dawley rat

Biological Species/NCBI Rattus norvegicus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

Measurement Parameter

AUC

Unit

µg.min/g

Quantitative value

6181

Jan, Kuo-Ching; Ho, Chi-Tang; Hwang, Lucy Sun; Journal of Agricultural and Food Chemistry; vol. 56; nb. 16; (2008); p. 7032 - 7037, View in Reaxys 70 of 191

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Bioassay Details

Species : Sprague-Dawley rat

Biological Species/NCBI Rattus norvegicus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

5 mg/kg

Substance Route of Adm.

intravenous administration

Measurement Parameter

AUC

Unit

µg.min/mL

Quantitative value

141.4

Jan, Kuo-Ching; Ho, Chi-Tang; Hwang, Lucy Sun; Journal of Agricultural and Food Chemistry; vol. 56; nb. 16; (2008); p. 7032 - 7037, View in Reaxys 71 of 191

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Bioassay Details

Species : Sprague-Dawley rat

Biological Species/NCBI Rattus norvegicus ID Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

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Measurement Parameter

AUC

Unit

µg.min/mL

Quantitative value

501.3

Jan, Kuo-Ching; Ho, Chi-Tang; Hwang, Lucy Sun; Journal of Agricultural and Food Chemistry; vol. 56; nb. 16; (2008); p. 7032 - 7037, View in Reaxys 72 of 191

Substance Effect

Antimutagenic

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Bioassay : N-OH-Trp-P-2 = N-hydroxy-3-amino-1-methyl-5H-pyrido<4,3-b>indole; scavenging activity of title comp. eval. from suppression of mutation induced ny N-OH-Trp-P-2; IC50 = conc. required for 50 percent scavenging of N-OH-Trp-P-2 radicals before damage to DNA in vitro; bacterial suspension containing title comp. and N-OH-Trp-P2; incub. for 20 min; poured on agar medium of minimal glucose; His+-revertant colonies count. after 2-d culture

Biological Species/NCBI Salmonella enterica subsp. enterica serovar Typhimurium ID Substance RN

127405View in Reaxys

Substance Name

173628

Measurement Parameter

IC50

Unit

Quantitative value

0.2

Measurement pX

3.7

Sun; Sakakibara; Ashida; Danno; Kanazawa; Bioscience, biotechnology, and biochemistry; vol. 64; nb. 11; (2000); p. 2395 - 2401, View in Reaxys 73 of 191

Substance Effect

Cytoprotective

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Name

Cell/tumor cell: proliferation/viability/growth

Bioassay Details

Bioassay : rats 4 weeks old; MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide test cells cultured on Matrigel-coated well at 37 deg C for 24 h; title comp. added; after 1 h acetaminophen added with final concentration of 20 mmol/l and incubated at 37 deg C for 48 h; survival rate measured by MTT assay

Biological Species/NCBI Rattus norvegicus ID Cells/Cell Lines

liver cell

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

40 µM

Qualitative Results

hepatoprotective activity 72.0 percent

Measurement Parameter

Qualitative

Nakagiri, Ryusuke; Oda, Hiroaki; Kamiya, Toshikazu; Bioscience, biotechnology, and biochemistry; vol. 67; nb. 8; (2003); p. 1629 - 1635, View in Reaxys 74 of 191

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Substance RN

127405View in Reaxys

Substance Name

173628

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Qualitative Results

effect on monoamine oxidase activity in rat C6 astrocyte cells (IC50 -3.47 log(M)); effect on H2O2 radical trapping ability (IC50 -5.26 log(M))

Measurement Parameter

Qualitative

Mazzio, Elizabeth A.; Harris, Natholyn; Soliman, Karam F. A.; Planta Medica; vol. 64; nb. 7; (1998); p. 603 - 606, View in Reaxys 75 of 191

Substance Effect

Apoptotic

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Name

Apoptosis

Bioassay Details

Effect : cells liftingethidium bromide and acridine orange dye method

Biological Species/NCBI Mus musculus ID Cells/Cell Lines

B16-F10

Substance RN

127405View in Reaxys

Substance Name

173628

Qualitative Results

effective concentration 100 μg/ml

Measurement Parameter

Qualitative

Mahendra Kumar; Sathisha; Dharmesh, Shylaja; Rao, A.G. Appu; Singh, Sridevi A.; Biochimie; vol. 93; nb. 3; (2011); p. 562 - 569, View in Reaxys 76 of 191

Substance Effect

Apoptotic

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Name

Apoptosis

Bioassay Details

Effect : spherical shapeethidium bromide and acridine orange dye method

Biological Species/NCBI Mus musculus ID Cells/Cell Lines

B16-F10

Substance RN

127405View in Reaxys

Substance Name

173628

Qualitative Results

effective concentration 100 μg/ml

Measurement Parameter

Qualitative

Mahendra Kumar; Sathisha; Dharmesh, Shylaja; Rao, A.G. Appu; Singh, Sridevi A.; Biochimie; vol. 93; nb. 3; (2011); p. 562 - 569, View in Reaxys 77 of 191

Substance Effect

Cytotoxic

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Name

Cell/tumor cell: proliferation/viability/growth

Bioassay Details

Effect : cell viabilityMTT assay

Biological Species/NCBI Mus musculus ID Cells/Cell Lines

B16-F10

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

100 µg/mL

Measurement Parameter

% Inhibition

Unit

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2017-10-14 23:10:10

Quantitative value

Measurement pX

3.32

Mahendra Kumar; Sathisha; Dharmesh, Shylaja; Rao, A.G. Appu; Singh, Sridevi A.; Biochimie; vol. 93; nb. 3; (2011); p. 562 - 569, View in Reaxys 78 of 191

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Enzymology inhibition

Bioassay Details

Effect : monophenolase activity enzyme activityTarget : monophenolase Bioassay : monophenolase

Biological Species/NCBI mushroom ID Substance RN

127405View in Reaxys

Substance Name

173628

Measurement Parameter

Unit

µM

Quantitative value

1.4

Measurement pX

5.85

Mahendra Kumar; Sathisha; Dharmesh, Shylaja; Rao, A.G. Appu; Singh, Sridevi A.; Biochimie; vol. 93; nb. 3; (2011); p. 562 - 569, View in Reaxys 79 of 191

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Enzymology inhibition

Bioassay Details

Effect : diphenolase activity enzyme activityTarget : diphenolase Bioassay : diphenolase

Substance RN

127405View in Reaxys

Substance Name

173628

Measurement Parameter

Unit

µM

Quantitative value

0.57

Measurement pX

6.24

Mahendra Kumar; Sathisha; Dharmesh, Shylaja; Rao, A.G. Appu; Singh, Sridevi A.; Biochimie; vol. 93; nb. 3; (2011); p. 562 - 569, View in Reaxys 80 of 191

Substance Effect

Apoptotic

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : apoptosisethidium bromide and acridine orange dye method

Biological Species/NCBI Mus musculus ID Cells/Cell Lines

B16-F10

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

100 µg/mL

Qualitative Results

rate of apoptotic cells ~ 40 - 50 percent

Measurement Parameter

Qualitative

Qualitative value

46/88

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Mahendra Kumar; Sathisha; Dharmesh, Shylaja; Rao, A.G. Appu; Singh, Sridevi A.; Biochimie; vol. 93; nb. 3; (2011); p. 562 - 569, View in Reaxys 81 of 191

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : melanin synthesis Target : melanin

Biological Species/NCBI Mus musculus ID Cells/Cell Lines

B16-F10

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

100 µg/mL

Measurement Parameter

% Inhibition

Unit

Qualitative value

Quantitative value

Measurement pX

3.37

Mahendra Kumar; Sathisha; Dharmesh, Shylaja; Rao, A.G. Appu; Singh, Sridevi A.; Biochimie; vol. 93; nb. 3; (2011); p. 562 - 569, View in Reaxys 82 of 191

Target Mutant/Chimera Details

enzyme:Wild

Target Subunit Proteins

enzyme

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |enzyme; examination of Bioassay : 37 deg C; substrate specificity enzyme cDNA by polymerase chain reaction; expression; cell lysis; protein purification; SDS-PAGE; enzyme activity with 13 μM <35S>-3'-phosphoadenosine 5'-phosphosulfate

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

1 µM

Qualitative Results

at 1 and 10 μM no, at 100 μM very low enzyme activity

Measurement Parameter

Qualitative

Target, Subunit, Species enzyme

83 of 191

Target Subunit Synonyms

catalytic; enzyme

Target Mutant/Chimera Details

enzyme:Wild

Target Subunit Proteins

enzyme

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |enzyme; examination of Bioassay : 37 deg C; substrate specificity enzyme cDNA isolation from human liver cDNA by polymerase chain reaction; expression; cell lysis; protein purification; SDS-PAGE; enzyme activity with 13 μM <35S>-3'-phosphoadenosine 5'phosphosulfate

Substance RN

127405View in Reaxys

47/88

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Substance Name

173628

Substance Dose

100 µM

Measurement Parameter

Qualitative

Qualitative value

Target, Subunit, Species enzyme

84 of 191

Target Subunit Synonyms

catalytic; enzyme

Substance Effect

Antioxidant

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Target : Wistar rat liver microsomesBioassay : TBA: thiobarbituric acid; dl-α-tocopherol with IC50 value of > 1000 μM used as positive control in vitro; effect on NADPH-induced lipid peroxidation assayed; 50 mM potassium phosphate buffer, pH 7.4; 10 μM FeSO4; 20 mM NaCl; NADPH-generating system; 37 deg C; incub. for 7.5 min; lipid peroxidation measured by TBA method

Substance RN

127405View in Reaxys

Substance Name

173628

Measurement Parameter

IC50

Unit

µM

Quantitative value

Measurement pX

4.24

Uchida, Mihoko; Nakajin, Shizuo; Toyoshima, Satoshi; Shinoda, Masato; Biological and Pharmaceutical Bulletin; vol. 19; nb. 4; (1996); p. 623 - 626, View in Reaxys 85 of 191

Target Mutant/Chimera Details

enzyme:Wild

Target Subunit Proteins

enzyme

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |enzyme; examination of Bioassay : 37 deg C; substrate specificity; SULT1A3 H143Y=sulfotransferase 1A3 Glu146 to Ala mutant enzyme cDNA mutagenesis; expression; cell lysis; protein purification; SDS-PAGE; enzyme activity with 13 μM <35S>-3'phosphoadenosine 5'-phosphosulfate

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

1 µM

Qualitative Results

dose-dependent, low enzyme activity

Measurement Parameter

Qualitative

Target, Subunit, Species enzyme

86 of 191

Target Subunit Synonyms

catalytic; enzyme

Target Mutant/Chimera Details

enzyme:Wild

Target Subunit Proteins

enzyme

Target Transfection

Non Transfected

48/88

2017-10-14 23:10:10

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |enzyme; examination of Bioassay : 37 deg C; substrate specificity; SULT1A3 H143Y=sulfotransferase 1A3 His143 to Tyr and Glu146 to Ala mutant enzyme cDNA mutagenesis; expression; cell lysis; protein purification; SDS-PAGE; enzyme activity with 13 μM <35S>-3'-phosphoadenosine 5'-phosphosulfate

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

1 µM

Qualitative Results

dose-dependent, low enzyme activity

Measurement Parameter

Qualitative

Target, Subunit, Species enzyme

87 of 191

Target Subunit Synonyms

catalytic; enzyme

Target Mutant/Chimera Details

enzyme:Wild

Target Subunit Proteins

enzyme

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |enzyme; examination of Bioassay : 37 deg C; substrate specificity; SULT1A3 H143Y=sulfotransferase 1A3 His143 to Tyr mutant enzyme cDNA mutagenesis; expression; cell lysis; protein purification; SDS-PAGE; enzyme activity with 13 μM <35S>-3'phosphoadenosine 5'-phosphosulfate

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

1 µM

Qualitative Results

at 1 and 10 μM no, at 100 μM very low enzyme activity

Measurement Parameter

Qualitative

Target, Subunit, Species enzyme

88 of 191

Target Subunit Synonyms

catalytic; enzyme

Substance Effect

Antioxidant

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Target : Wistar rat liver microsomesBioassay : TBA: thiobarbituric acid; dl-α-tocopherol with IC50 value of 22 μM used as positive control in vitro; effect on CCl4-induced lipid peroxidation assayed; 50 mM potassium phosphate buffer, pH 7.4; 3.4 mM CCl4; 20 mM NaCl; 0.6 mM EDTA; NADPH-generating system; 37 deg C; incub. for 7.5 min; lipid peroxidation measured by TBA method

Substance RN

127405View in Reaxys

Substance Name

173628

Measurement Parameter

IC50

Unit

µM

Quantitative value

Measurement pX

4.52

49/88

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Uchida, Mihoko; Nakajin, Shizuo; Toyoshima, Satoshi; Shinoda, Masato; Biological and Pharmaceutical Bulletin; vol. 19; nb. 4; (1996); p. 623 - 626, View in Reaxys 89 of 191

Substance Effect

Antioxidant

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Target : Wistar rat liver mitochondriaBioassay : dl-α-tocopherol with IC50 value of 16 μM used as positive control in vitro; effect on ascorbate/Fe2+-induced lipid peroxidation assayed; Tris-HCl buffer, pH 7.4; sucrose; 10 μM FeSO4; 40 μM sodium ascorbate; 37 deg C; incub. for 20 min; lipid peroxidation assessed by measuring oxygen uptake

Substance RN

127405View in Reaxys

Substance Name

173628

Measurement Parameter

IC50

Unit

µM

Quantitative value

Measurement pX

4.46

Uchida, Mihoko; Nakajin, Shizuo; Toyoshima, Satoshi; Shinoda, Masato; Biological and Pharmaceutical Bulletin; vol. 19; nb. 4; (1996); p. 623 - 626, View in Reaxys 90 of 191

Substance Effect

Antioxidant

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Target : lecithin liposomesBioassay : TBA: thiobarbituric acid; dl-α-tocopherol with IC50 value of 18 μM used as positive control in vitro; effect on Fe2+-induced lipid peroxidation assayed; 50 mM potassium phosphate buffer, pH 7.4; 1 mM FeSO4; 25 deg C; incub. for 60 min; lipid peroxidation measured by TBA method

Substance RN

127405View in Reaxys

Substance Name

173628

Measurement Parameter

IC50

Unit

µM

Quantitative value

Measurement pX

4.32

Uchida, Mihoko; Nakajin, Shizuo; Toyoshima, Satoshi; Shinoda, Masato; Biological and Pharmaceutical Bulletin; vol. 19; nb. 4; (1996); p. 623 - 626, View in Reaxys 91 of 191

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Substance RN

127405View in Reaxys

Substance Name

173628

Qualitative Results

superoxide dismutase (SOD)-like activity of title comp. evaluated by measuring the inhibition of pyrogallol autoxidation that is catalyzed by the superoxide radical - -4percent

Measurement Parameter

Qualitative

Kim; Han; Moon; Rhee; Bioscience, biotechnology, and biochemistry; vol. 59; nb. 5; (1995); p. 822 - 826, View in Reaxys 92 of 191

Substance Effect

Antiproliferative

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Bioassay : control: PBS-treated cells; CP-Hsp60-1: recombinant Chlamydia pneumoniae J138 chaperonin 60-1 effect on CP-Hsp60-1-induced cell proliferation evaluated; 1E5

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cells; DMEM with 10 percent FCS; 37 deg C; incubated for 1 d; starved in serum-deficient DMEM for 48 h; 10 μg/ml CP-Hsp60-1 added for further 48 h; cells enumerated Biological Species/NCBI Rattus norvegicus ID Cells/Cell Lines

vascular smooth muscle cell

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

10 mg/L

Qualitative Results

title comp. exhibited moderate inhibitory action on CP-Hsp60-1-induced cell proliferation

Measurement Parameter

Qualitative

Substance Effect

Antioxidant

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Target : SPF BALB/c mouseBioassay : groups: group A: deionized water (i.p.); group B: Fe-NTA (4 mg/kg, i.p.); group C: title comp. only; group D: Fe-NTA + title comp.; Fe-NTA was used to induce acute renal failure mice in groups treated with title comp. and/or ferricnitrilotriacetate (Fe-NTA); kidneys removed at 3 h post-dose; homogenized; hydroxyl radical and superoxide anion levels were measured by high-performance chemiluminescence analyzer

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

30 mg/kg

Substance Route of Adm.

subcutaneous administration

Qualitative Results

Fe-NTA increased hydroxyl radical and superoxide anion levels compared to the A and C groups, but title comp. blocked the levels of both free radicals from rising in the D group; fig.

Measurement Parameter

Qualitative

Hsu, Dur-Zong; Wan, Chang-Hsin; Hsu, Hua-Fen; Lin, Yung-Ming; Liu, Ming-Yie; Food and Chemical Toxicology; vol. 46; nb. 8; (2008); p. 2736 - 2741, View in Reaxys 94 of 191

Substance Effect

Antioxidant

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Target : SPF BALB/c mouseBioassay : groups: group A: deionized water (i.p.); group B: Fe-NTA (4 mg/kg, i.p.); group C: title comp. only; group D: Fe-NTA + title comp.; Fe-NTA was used to induce acute renal failure mice in groups treated with title comp. and/or ferricnitrilotriacetate (Fe-NTA); kidneys removed at 3 h post-dose; homogenized; supernatant removed; xanthine oxidase activity detd.

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

30 mg/kg

Substance Route of Adm.

subcutaneous administration

Qualitative Results

Fe-NTA increased the activity of xanthine oxidase compared to the A and C groups while title comp. significantly inhibited the activity of xanthine oxidase in group D compared to the B group; fig.

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Measurement Parameter

Qualitative

Hsu, Dur-Zong; Wan, Chang-Hsin; Hsu, Hua-Fen; Lin, Yung-Ming; Liu, Ming-Yie; Food and Chemical Toxicology; vol. 46; nb. 8; (2008); p. 2736 - 2741, View in Reaxys 95 of 191

Substance Effect

Antioxidant

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Target : SPF BALB/c mouseBioassay : groups: group A: deionized water (i.p.); group B: Fe-NTA (4 mg/kg, i.p.); group C: title comp. only; group D: Fe-NTA + title comp.; Fe-NTA was used to induce acute renal failure mice in groups treated with title comp. and/or ferricnitrilotriacetate (Fe-NTA); kidneys removed 3 h post-dose; homogenized; supernatant removed; lipid peroxidation detd. spectrophotometrically at 586 nm

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

30 mg/kg

Substance Route of Adm.

subcutaneous administration

Qualitative Results

Fe-NTA increased kidney lipid peroxidation compared to both A and C groups; title comp. significantly blocked these levels from rising in group D compared to the B group; fig.

Measurement Parameter

Qualitative

Hsu, Dur-Zong; Wan, Chang-Hsin; Hsu, Hua-Fen; Lin, Yung-Ming; Liu, Ming-Yie; Food and Chemical Toxicology; vol. 46; nb. 8; (2008); p. 2736 - 2741, View in Reaxys 96 of 191

Substance Effect

Nephroprotective

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Target : SPF BALB/c mouseBioassay : groups: group A: deionized water (i.p.); group B: Fe-NTA (4 mg/kg, i.p.); group C: title comp. only; group D: Fe-NTA + title comp.; Fe-NTA was used to induce acute renal failure mice in groups treated with title comp. and/or ferricnitrilotriacetate (Fe-NTA); blood and urine samples collected; serum levels of blood urea nitrogen (BUN) and creatinine detd. 3 h post-dose; creatinine clearance rate (CCr) detd. 24 h post-dose

Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

30 mg/kg

Substance Route of Adm.

subcutaneous administration

Qualitative Results

serum BUN and creatinine levels were signif. higher in B group than in A and C groups; BUN and creatinine were signif. lower in D group than in B group; title comp. prevented Fe-NTA-induced block of CCr levels in group D compared to B group; fig.

Measurement Parameter

Qualitative

Hsu, Dur-Zong; Wan, Chang-Hsin; Hsu, Hua-Fen; Lin, Yung-Ming; Liu, Ming-Yie; Food and Chemical Toxicology; vol. 46; nb. 8; (2008); p. 2736 - 2741, View in Reaxys 97 of 191

Substance Effect

Nephroprotective

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Target : SPF BALB/c mouseBioassay : groups: group A: deionized water (i.p.); group B: Fe-NTA (4 mg/kg, i.p.); group C: title comp. only; group D: Fe-NTA + title comp.; Fe-NTA was used to induce acute renal failure mice in groups treated with title comp. and/or ferricnitrilotriacetate (Fe-NTA); 3 h post-dose, kidneys removed; histopathology performed

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Substance RN

127405View in Reaxys

Substance Name

173628

Substance Dose

30 mg/kg

Substance Route of Adm.

subcutaneous administration

Qualitative Results

kidneys for B group showed degeneration and necrosis in the renal tubular region; no necrosis obsd. in the D group; fig.

Measurement Parameter

Qualitative

Hsu, Dur-Zong; Wan, Chang-Hsin; Hsu, Hua-Fen; Lin, Yung-Ming; Liu, Ming-Yie; Food and Chemical Toxicology; vol. 46; nb. 8; (2008); p. 2736 - 2741, View in Reaxys 98 of 191

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lowest published toxic dose

Biological Species/NCBI Mus musculus ID Substance RN

127405View in Reaxys

Unit

g/kg

Qualitative value

Quantitative value

1092

Tamano; Hirose; Tanaka; Asakawa; Ogawa; Ito; Japanese Journal of Cancer Research; vol. 83; nb. 12; (1992); p. 1279 - 1285, View in Reaxys

99 of 191

Measurement Object

Lowest published toxic dose

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lowest published toxic dose

Biological Species/NCBI Rattus norvegicus ID Substance RN

127405View in Reaxys

Unit

g/kg

Qualitative value

Quantitative value

874

Tamano; Hirose; Tanaka; Asakawa; Ogawa; Ito; Japanese Journal of Cancer Research; vol. 83; nb. 12; (1992); p. 1279 - 1285, View in Reaxys Measurement Object 100 of 191 Bioassay Category Bioassay Details

Lowest published toxic dose Toxicity/Safety Pharmacology Carcinogenicity of the compound in rat; '+' indicates active

Biological Species/NCBI Rattus norvegicus ID Substance RN

127405View in Reaxys

Measurement Parameter

Qualitative

Qualitative value

Not Published

Klopman, Gilles; Chakravarti, Suman K; Zhu, Hao; Ivanov, Julian M; Saiakhov, Roustem D; Journal of chemical information and computer sciences; vol. 44; nb. 2; (2004); p. 704 - 715, View in Reaxys 101 of 191 Bioassay Category Bioassay Details

Toxicity/Safety Pharmacology Toxic dose (other than lowest);Oral;96W-C

Biological Species/NCBI Mus musculus ID

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Substance RN

127405View in Reaxys

Substance Route of Adm.

oral administration

Measurement Parameter

Unit

g/kg

Qualitative value

Quantitative value

1612

Hirose; Fukushima; Shirai; Hasegawa; Kato; Tanaka; Asakawa; Ito; Japanese Journal of Cancer Research; vol. 81; nb. 3; (1990); p. 207 - 212, View in Reaxys 102 of 191 Bioassay Category Bioassay Details

Toxicity/Safety Pharmacology Carcinogenicity of the compound in mouse; '+' indicates active

Biological Species/NCBI Mus musculus ID Substance RN

127405View in Reaxys

Measurement Parameter

Qualitative

Qualitative value

Not Published

estrogen receptor [human]:Wild

Substance Action on Target

Radioligand (/ligand)

Target Species (Bioactivity)

human

Target Subunit Proteins

estrogen receptor [human]

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Relative binding affinity of the compound towards recombinant human Estrogen receptor alpha

Biological Species/NCBI Human ID Substance RN

127405View in Reaxys

Qualitative Results

N.B = non binder

Measurement Parameter

Qualitative

Qualitative value

Not Published

Target, Subunit, Species estrogen receptor [human] Target Subunit Synonyms

er; er-alpha; esr; esr1; estradiol receptor; estrogen receptor; nr3a1; nuclear receptor subfamily 3 group a member 1

Target Uniprot ID

p03372

Target PDB ID

1a52; 1ere; 1err; 1g50; 1gwq; 1gwr; 1hcq; 1l2i; 1pcg; 1qkt; 1qku; 1r5k; 1sj0; 1uom; 1x7e; 1x7r; 1xp1; 1xp6; 1xp9; 1xpc; 1xqc; 1yim; 1yin; 1zky; 2ayr; 2b1v; 2b1z; 2b23; 2bj4; 2fai; 2g44; 2g5o; 2i0j; 2iog; 2iok; 2jf9; 2jfa; 2ocf; 2ouz; 2p15; 2pog; 2q6j; 2q70; 2qa6; 2qa8; 2qab; 2qe4; 2qgt; 2qgw; 2qh6; 2qr9; 2qse; 2qxm; 2qxs; 2qzo; 2r6w; 2r6y; 2yat; 2yja; 3cbm; 3cbo; 3cbp; 3dt3; 3erd; 3ert; 3hlv; 3hm1; 3l03; 3os8; 3os9; 3osa; 3q95; 3q97; 3uu7; 3uua; 3uuc; 3uud; 4aa6; 4dma; 4iu7; 4iui; 4iv2; 4iv4; 4ivw; 4ivy; 4iw6; 4iw8; 4iwc; 4iwf; 4jc3; 4jdd; 4mg5; 4mg6; 4mg7; 4mg8; 4mg9; 4mga; 4mgb; 4mgc; 4mgd; 4o6f; 4pp6; 4ppp; 4pps; 4pxm; 4q13; 4q50; 4tuz; 4tv1; 5ak2

104 of 191 Substance Action on Target

Inhibitor

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Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Inhibitory concentration of the compound against melanin production in the mammalian melanocytes culture pigment assay system

Cells/Cell Lines

Melanocyte

Substance RN

127405View in Reaxys

Measurement Parameter

IC50

Unit

µM

Qualitative value

Quantitative value

209

Measurement pX

3.68

Patent; Dooley, Thomas P.; Curto, Ernest V.; US2002/44914; (2002); (A1) English, View in Reaxys Measurement Object 105 of 191 Target Mutant/Chimera Details

Inhibition of melanin production integrase [Human immunodeficiency virus 1]:Wild

Target Species (Bioactivity)

Human immunodeficiency virus 1

Target Subunit Proteins

integrase [Human immunodeficiency virus 1]

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity (KD) of the compound against HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PNL43 Integrase expressed in Escherichia coli was determined

Biological Species/NCBI Human immunodeficiency virus 1 PNL4 3 ID Substance RN

127405View in Reaxys

Measurement Parameter

Unit

Quantitative value

5.5

Measurement pX

2.26

Target, Subunit, Species integrase [Human immunodeficiency virus 1] Target Subunit Synonyms

integrase

Measurement Object

106 of 191 Target Mutant/Chimera Details

Tyrosinase:Wild

Substance Action on Target

Inhibitor

Target Subunit Proteins

Tyrosinase

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Inhibitory concentration of the compound against mammalian melanocytes Tyrosinase in the cell-free mammalian-enzyme assay system

Cells/Cell Lines

Melanocyte

Substance RN

127405View in Reaxys

Measurement Parameter

IC50

Unit

µM

Qualitative value

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Quantitative value

Measurement pX

4.01

Target, Subunit, Species Tyrosinase Patent; Dooley, Thomas P.; Curto, Ernest V.; US2002/44914; (2002); (A1) English, View in Reaxys Target Subunit Synonyms

107 of 191 Substance Action on Target

90c4.150; afua_1g17430; albino locus protein; ao090038000061; lb24-ab; mel (tyrosinase); mela (tyrosinase); melc2; melo; mepa (tyrosinase); monophenol monooxygenase (tyrosinase); ncu00776; sk29-ab; t (tyrosinase); tumor rejection antigen ab; tyr (tyrosinase); tyr1 (tyrosinase); tyro; tyrosinase; tyrs (tyrosinase) Inhibitor

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Inhibitory concentration of the compound against mammalian melanocytes in mammalianmelanocyte-culture toxicity assay system

Cells/Cell Lines

Melanocyte

Substance RN

127405View in Reaxys

Measurement Parameter

IC50

Unit

µM

Qualitative value

Quantitative value

775

Measurement pX

3.11

Patent; Dooley, Thomas P.; Curto, Ernest V.; US2002/44914; (2002); (A1) English, View in Reaxys Measurement Object 108 of 191 Substance Effect

Toxicity Antibiotic

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Name

Cell/tumor cell: proliferation/viability/growth

Biological Species/NCBI Staphylococcus aureus MTCC 96 ID Substance RN

127405View in Reaxys

Substance Name

table 2+3+4, compound sesamol

Measurement Parameter

MIC

Unit

µg/mL

Quantitative value

Measurement pX

3.33

Singh, Harjinder; Sindhu, Jayant; Khurana, Jitender M.; Sharma, Chetan; Aneja; RSC Advances; vol. 4; nb. 12; (2014); p. 5915 - 5926, View in Reaxys 109 of 191 Substance Effect

Antibiotic

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Name

Cell/tumor cell: proliferation/viability/growth

Biological Species/NCBI Bacillus subtilis MTCC 121 ID Substance RN

127405View in Reaxys

Substance Name

table 2+3+4, compound sesamol

Measurement Parameter

MIC

Unit

µg/mL

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Quantitative value

Measurement pX

3.63

Singh, Harjinder; Sindhu, Jayant; Khurana, Jitender M.; Sharma, Chetan; Aneja; RSC Advances; vol. 4; nb. 12; (2014); p. 5915 - 5926, View in Reaxys 110 of 191

Substance Effect

Antibiotic

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Name

Cell/tumor cell: proliferation/viability/growth

Biological Species/NCBI Escherichia coli MTCC 1652 ID Substance RN

127405View in Reaxys

Substance Name

table 2+3+4, compound sesamol

Measurement Parameter

MIC

Unit

µg/mL

Quantitative value

256

Measurement pX

2.73

Singh, Harjinder; Sindhu, Jayant; Khurana, Jitender M.; Sharma, Chetan; Aneja; RSC Advances; vol. 4; nb. 12; (2014); p. 5915 - 5926, View in Reaxys 111 of 191

Substance Effect

Antifungal

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Name

Cell/tumor cell: proliferation/viability/growth

Biological Species/NCBI Aspergillus niger ID Substance RN

127405View in Reaxys

Substance Name

table 2+3+4, compound sesamol

Measurement Parameter

% Inhibition

Unit

Quantitative value

47.6

Singh, Harjinder; Sindhu, Jayant; Khurana, Jitender M.; Sharma, Chetan; Aneja; RSC Advances; vol. 4; nb. 12; (2014); p. 5915 - 5926, View in Reaxys 112 of 191

Substance Effect

Antifungal

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Name

Cell/tumor cell: proliferation/viability/growth

Biological Species/NCBI Aspergillus flavus ID Substance RN

127405View in Reaxys

Substance Name

table 2+3+4, compound sesamol

Measurement Parameter

% Inhibition

Unit

Quantitative value

45.2

Singh, Harjinder; Sindhu, Jayant; Khurana, Jitender M.; Sharma, Chetan; Aneja; RSC Advances; vol. 4; nb. 12; (2014); p. 5915 - 5926, View in Reaxys 113 of 191

Target Mutant/Chimera Details

Catenin beta-1:Wild

Target Subunit Proteins

Catenin beta-1

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Substance Effect

transcriptional

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Relative luciferase activity in HEK 293 cells expressing BETA-CATENIN co-transfected with luciferase reporter plasmid (TOPflash or FOPflash) upon incubation with 20 uM compound for 24 hrs by DUAL LUCIFERASE ASSAY SYSTEM when compared to the vehicle control

Cells/Cell Lines

HEK 293

Substance RN

127405View in Reaxys

Measurement Parameter

Activity

Qualitative value

Quantitative value

89.9

Target, Subunit, Species Catenin beta-1

114 of 191

Target Subunit Synonyms

arm (catenin beta-1); armadillo segment polarity protein (catenin beta-1); beta-catenin (catenin beta-1); catenin beta-1; catnb; cg11579; ctnnb; ctnnb1 (catenin beta-1); hmp-2; k05c4.6; ok/sw-cl.35; pro2286; protein humpback-2

Measurement Object

Relative luciferase activity

Target Mutant/Chimera Details

Catenin beta-1:Wild

Target Subunit Proteins

Catenin beta-1

Substance Effect

transcriptional

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Percent inhibition of luciferase activity in HEK 293 cells expressing BETA-CATENIN cotransfected with luciferase reporter plasmid (TOPflash or FOPflash) upon incubation with 20 uM compound for 24 hrs by DUAL LUCIFERASE ASSAY SYSTEM

Cells/Cell Lines

HEK 293

Substance RN

127405View in Reaxys

Measurement Parameter

% Inhibition

Unit

Qualitative value

Quantitative value

10.1

Measurement pX

Target, Subunit, Species Catenin beta-1

115 of 191

Target Subunit Synonyms

Measurement Object

Luciferase activity

Substance Effect

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

Amount decrease

Qualitative value

Not active

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Statistical sgnificance (Qualitative)

Measurement pX

Chen, Wei-Yu; Chen, Fang-Yu; Lee, An-Sheng; Ting, Kuan-Hsiang; Chang, Chia-Ming; Hsu, Jing-Fang; Lee, Wei-Shine; Sheu, Joen-Rong; Chen, Chu-Huang; Shen, Ming-Yi; Journal of Natural Products; vol. 78; nb. 2; (2015); p. 225 - 233, View in Reaxys

116 of 191

Compound RN

67676

Compound role

COM

Substance Effect

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

Amount decrease

Qualitative value

Not active

Statistical sgnificance (Qualitative)

Measurement pX

117 of 191

Compound RN

28059126

Compound role

COM

Substance Effect

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

Amount decrease

Qualitative value

Not active

Statistical sgnificance (Qualitative)

Measurement pX

118 of 191

Compound RN

28059127

Compound role

COM

Substance Effect

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

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Substance Dose

3 μM

Measurement Parameter

Amount decrease

Qualitative value

Not active

Statistical sgnificance (Qualitative)

Measurement pX

119 of 191

Compound RN

28059127

Compound role

COM

Substance Effect

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

Amount increase

Qualitative value

Active

Statistical sgnificance (Qualitative)

Measurement pX

5.52

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

Amount increase

Qualitative value

Active

Statistical sgnificance (Qualitative)

Measurement pX

5.52

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

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Substance Dose

3 μM

Measurement Parameter

Amount increase

Qualitative value

Active

Statistical sgnificance (Qualitative)

Measurement pX

5.52

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

Amount increase

Qualitative value

Active

Measurement pX

5.52

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

Amount increase

Qualitative value

Active

Statistical sgnificance (Qualitative)

Measurement pX

5.52

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

Amount increase

Qualitative value

Active

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Statistical sgnificance (Qualitative)

Measurement pX

5.52

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

Amount increase

Qualitative value

Active

Statistical sgnificance (Qualitative)

Measurement pX

5.52

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

Amount increase

Qualitative value

Active

Statistical sgnificance (Qualitative)

Measurement pX

5.52

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

Amount increase

Qualitative value

Active

Statistical sgnificance (Qualitative)

Measurement pX

5.52

62/88

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Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

Amount increase

Qualitative value

Active

Measurement pX

5.52

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

Amount increase

Qualitative value

Active

Statistical sgnificance (Qualitative)

Measurement pX

5.52

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

Amount increase

Qualitative value

Active

Statistical sgnificance (Qualitative)

Measurement pX

5.52

Anti-Atherogenis In Vitro (Efficacy)

63/88

2017-10-14 23:10:10

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

Amount increase

Qualitative value

Not active

Statistical sgnificance (Qualitative)

Measurement pX

67676

Compound role

COM

132 of 191 Substance Effect

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

Amount increase

Qualitative value

Not active

Statistical sgnificance (Qualitative)

Measurement pX

28059126

Compound role

COM

133 of 191 Substance Effect

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

Amount increase

Qualitative value

Not active

Statistical sgnificance (Qualitative)

Measurement pX

64/88

2017-10-14 23:10:10

Compound RN

67676

Compound role

COM

134 of 191 Substance Effect

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

Amount increase

Qualitative value

Not active

Statistical sgnificance (Qualitative)

Measurement pX

28059126

Compound role

COM

135 of 191 Substance Effect Bioassay Category

Anti-Arteriosclerosis In Vivo (Animal models)

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

% Inhibition

Qualitative value

Active

Statistical sgnificance (Qualitative)

Triglyceride Anti-Arteriosclerosis In Vivo (Animal models)

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

100 mg/kg

Substance Route of Adm.

oral administration

65/88

2017-10-14 23:10:10

Substance Dosing Regi- Repeated men Measurement Parameter

% Inhibition

Qualitative value

Active

Statistical sgnificance (Qualitative)

Triglyceride Anti-Arteriosclerosis In Vivo (Animal models)

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

100 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

% decrease

Qualitative value

Active

Statistical sgnificance (Qualitative)

Total Anti-Arteriosclerosis In Vivo (Animal models)

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

% decrease

Qualitative value

Active

Statistical sgnificance (Qualitative)

66/88

2017-10-14 23:10:10

Measurement Object 139 of 191 Substance Effect Bioassay Category

Total Anti-Arteriosclerosis In Vivo (Animal models)

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

100 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Unit

Quantitative value

5.7

Statistical sgnificance (Qualitative)

L5/LDL level Anti-Arteriosclerosis In Vivo (Animal models)

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Unit

Quantitative value

9.5

Statistical sgnificance (Qualitative)

L5/LDL level Anti-Arteriosclerosis In Vivo (Animal models)

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

67/88

2017-10-14 23:10:10

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

% Inhibition

Qualitative value

Active

Statistical sgnificance (Qualitative)

Total Anti-Arteriosclerosis In Vivo (Animal models)

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

100 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

% Inhibition

Qualitative value

Active

Statistical sgnificance (Qualitative)

Total Anti-Arteriosclerosis In Vivo (Animal models)

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

% Inhibition

Qualitative value

Active

68/88

2017-10-14 23:10:10

Statistical sgnificance (Qualitative)

Anti-Arteriosclerosis In Vivo (Animal models)

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

100 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

% Inhibition

Qualitative value

Active

Statistical sgnificance (Qualitative)

Anti-Arteriosclerosis In Vivo (Animal models)

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

% Increase

Qualitative value

Active

Statistical sgnificance (Qualitative)

Anti-Arteriosclerosis In Vivo (Animal models)

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

100 mg/kg

69/88

2017-10-14 23:10:10

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

% Increase

Qualitative value

Active

Statistical sgnificance (Qualitative)

Anti-Arteriosclerosis In Vivo (Animal models)

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

% Inhibition

Qualitative value

Active

Statistical sgnificance (Qualitative)

Anti-Arteriosclerosis In Vivo (Animal models)

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

100 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

% Inhibition

Qualitative value

Active

Statistical sgnificance (Qualitative)

70/88

2017-10-14 23:10:10

149 of 191 Substance Effect Bioassay Category

Anti-Arteriosclerosis In Vivo (Animal models)

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

% Inhibition

Qualitative value

Active

Statistical sgnificance (Qualitative)

VLDL-cholesterol + LDL-cholesterol Anti-Arteriosclerosis In Vivo (Animal models)

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

100 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

% Inhibition

Qualitative value

Active

Statistical sgnificance (Qualitative)

VLDL-cholesterol + LDL-cholesterol Toxic Toxicity/Safety Pharmacology

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

71/88

2017-10-14 23:10:10

Substance Dosing Regi- Repeated men Measurement Parameter

Mortality rate

Unit

Quantitative value

Toxic Toxicity/Safety Pharmacology

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

100 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Mortality rate

Unit

Quantitative value

Toxic Toxicity/Safety Pharmacology

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

% decrease

Qualitative value

Not active

Measurement pX

Toxic Toxicity/Safety Pharmacology

Biological Species/NCBI Syrian hamster ID

72/88

2017-10-14 23:10:10

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

100 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

% decrease

Qualitative value

Not active

Measurement pX

Anti-Arteriosclerosis In Vivo (Animal models)

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

% Inhibition

Unit

Quantitative value

31.5

Statistical sgnificance (Qualitative)

atherosclerotic lesion Anti-Arteriosclerosis In Vivo (Animal models)

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

100 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

% Inhibition

Unit

73/88

2017-10-14 23:10:10

Quantitative value

47.3

atherosclerotic lesion Anti-Arteriosclerosis In Vivo (Animal models)

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

50 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Amount decrease

Qualitative value

Active

Caspase 3 expression Anti-Arteriosclerosis In Vivo (Animal models)

Biological Species/NCBI Syrian hamster ID Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

100 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Amount decrease

Qualitative value

Active

Caspase 3 expression Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

1 μM

74/88

2017-10-14 23:10:10

Measurement Parameter

% Inhibition

Qualitative value

Active

Statistical sgnificance (Qualitative)

Measurement pX

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

% Inhibition

Qualitative value

Active

Statistical sgnificance (Qualitative)

Measurement pX

5.52

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

0.3 μM

Measurement Parameter

% Inhibition

Qualitative value

Active

Statistical sgnificance (Qualitative)

Measurement pX

6.52

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

0.3 μM

Measurement Parameter

% Inhibition

Qualitative value

Active

75/88

2017-10-14 23:10:10

Statistical sgnificance (Qualitative)

Measurement pX

6.52

of caspase 3 activity Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

1 μM

Measurement Parameter

% Inhibition

Qualitative value

Active

Statistical sgnificance (Qualitative)

Measurement pX

of caspase 3 activity Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

% Inhibition

Qualitative value

Active

Statistical sgnificance (Qualitative)

Measurement pX

5.52

of caspase 3 activity Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

% Inhibition

76/88

2017-10-14 23:10:10

Qualitative value

Active

Measurement pX

5.52

internalization of L5 Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

0.3 - 3 μM

Measurement Parameter

Amount decrease

Qualitative value

Active

Statistical sgnificance (Qualitative)

Measurement pX

6.52

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

0.3 - 3 μM

Measurement Parameter

Amount decrease

Qualitative value

Active

Statistical sgnificance (Qualitative)

Measurement pX

6.52

Anti-Atherogenis

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HAEC

Substance RN

127405View in Reaxys

Substance Name

5-hydroxy-1,3-benzodioxole

Substance Dose

3 μM

Measurement Parameter

Amount increase

Qualitative value

Active

Statistical sgnificance (Qualitative)

77/88

2017-10-14 23:10:10

Measurement pX

5.52

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

4 - 16 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

% decrease

Qualitative value

Active

Statistical sgnificance (Qualitative)

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Measurement Object

mean escape latency

Compound RN

8151893

Compound name

streptozocin

Compound role

IND

170 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

4 - 16 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

% increase

Qualitative value

Active

Statistical sgnificance (Qualitative)

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Measurement Object

time spent in target qudrant

Compound RN

8151893

Compound name

streptozocin

Compound role

IND

171 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID

78/88

2017-10-14 23:10:10

Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

4 - 16 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

% decrease

Qualitative value

Active

Statistical sgnificance (Qualitative)

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Measurement Object

initial transfer latency

Compound RN

8151893

Compound name

streptozocin

Compound role

IND

172 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

4 -16 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

Qualitative

Qualitative value

Not active

Measurement pX

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Measurement Object

Locomotor activity

Compound RN

8151893

Compound name

streptozocin

Compound role

IND

173 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

8 - 16 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

Amount decrease

Qualitative value

Active

79/88

2017-10-14 23:10:10

Statistical sgnificance (Qualitative)

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Compound RN

8151893

Compound name

streptozocin

Compound role

IND

174 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

8 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

Amount increase

Unit

μmol/min/mg protein

Quantitative value

0.051

Statistical sgnificance (Qualitative)

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Compound RN

8151893

Compound name

streptozocin

Compound role

IND

175 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

16 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

Amount increase

Unit

μmol/min/mg protein

Quantitative value

0.37

Statistical sgnificance (Qualitative)

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Compound RN

8151893

Compound name

streptozocin

Compound role

IND

80/88

2017-10-14 23:10:10

176 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

4 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

Amount increase

Unit

μmol/min/mg protein

Quantitative value

0.065

Statistical sgnificance (Qualitative)

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Compound RN

8151893

Compound name

streptozocin

Compound role

IND

177 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

4 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

Amount decrease

Unit

nmol/mg protein

Quantitative value

2.48

Statistical sgnificance (Qualitative)

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Measurement Object

Lipid peroxide

Compound RN

8151893

Compound name

streptozocin

Compound role

IND

178 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

81/88

2017-10-14 23:10:10

Substance Dose

8 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

Amount decrease

Unit

nmol/mg protein

Quantitative value

2.03

Statistical sgnificance (Qualitative)

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Measurement Object

Lipid peroxide

Compound RN

8151893

Compound name

streptozocin

Compound role

IND

179 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

16 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

Amount decrease

Unit

nmol/mg protein

Quantitative value

1.68

Statistical sgnificance (Qualitative)

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Measurement Object

Lipid peroxide

Compound RN

8151893

Compound name

streptozocin

Compound role

IND

180 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

4 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

Amount increase

82/88

2017-10-14 23:10:10

Unit

μmol/mg protein

Quantitative value

0.0096

Statistical sgnificance (Qualitative)

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Measurement Object

reduced glutathione content

Compound RN

8151893

Compound name

streptozocin

Compound role

IND

181 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

8 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

Amount increase

Unit

μmol/mg protein

Quantitative value

0.0127

Statistical sgnificance (Qualitative)

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Measurement Object

reduced glutathione content

Compound RN

8151893

Compound name

streptozocin

Compound role

IND

182 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

16 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

Amount increase

Unit

μmol/mg protein

Quantitative value

0.0156

Statistical sgnificance (Qualitative)

83/88

2017-10-14 23:10:10

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Measurement Object

reduced glutathione content

Compound RN

8151893

Compound name

streptozocin

Compound role

IND

183 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

4 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

Amount increase

Unit

unit/mg protein

Quantitative value

1.1

Statistical sgnificance (Qualitative)

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Compound RN

8151893

Compound name

streptozocin

Compound role

IND

184 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

8 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

Amount increase

Unit

unit/mg protein

Quantitative value

1.678

Statistical sgnificance (Qualitative)

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Compound RN

8151893

Compound name

streptozocin

Compound role

IND

185 of 191 Substance Effect

Anti-Alzheimer

84/88

2017-10-14 23:10:10

Bioassay Category

In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

16 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

Amount increase

Unit

unit/mg protein

Quantitative value

2.34

Statistical sgnificance (Qualitative)

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Compound RN

8151893

Compound name

streptozocin

Compound role

IND

186 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

16 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

Amount increase

Unit

μmol/min/mg protein

Quantitative value

24.56

Statistical sgnificance (Qualitative)

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Compound RN

8151893

Compound name

streptozocin

Compound role

IND

187 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

4 mg/kg

85/88

2017-10-14 23:10:10

Substance Dosing Regi- Repeated men Measurement Parameter

Amount increase

Unit

μmol/min/mg protein

Quantitative value

11.34

Statistical sgnificance (Qualitative)

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Compound RN

8151893

Compound name

streptozocin

Compound role

IND

188 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

8 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

Amount increase

Unit

μmol/min/mg protein

Quantitative value

18.9

Statistical sgnificance (Qualitative)

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Compound RN

8151893

Compound name

streptozocin

Compound role

IND

189 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

16 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

Amount decrease

Unit

μg/ml

Quantitative value

159.68

Statistical sgnificance (Qualitative)

86/88

2017-10-14 23:10:10

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Measurement Object

of nitrite

Compound RN

8151893

Compound name

streptozocin

Compound role

IND

190 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

8 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

Amount decrease

Unit

μg/ml

Quantitative value

172.91

Statistical sgnificance (Qualitative)

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Measurement Object

of nitrite

Compound RN

8151893

Compound name

streptozocin

Compound role

IND

191 of 191 Substance Effect Bioassay Category

Anti-Alzheimer In Vivo (Animal models)

Biological Species/NCBI Wistar rat ID Substance RN

127405View in Reaxys

Substance Name

sesamol

Substance Dose

4 mg/kg

Substance Dosing Regi- Repeated men Measurement Parameter

Amount decrease

Unit

μg/ml

Quantitative value

188.78

Statistical sgnificance (Qualitative)

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit; European Journal of Pharmacology; vol. 747; (2014); p. 132 - 140, View in Reaxys Measurement Object

of nitrite

Compound RN

8151893

Compound name

streptozocin

87/88

2017-10-14 23:10:10

Compound role

IND

88/88

2017-10-14 23:10:10