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9 substances in Reaxys
2017-11-06 12h:42m:30s (EST)
1 substances in Reaxys
2017-11-06 12h:43m:26s (EST)
O
1. Query
O O O
O
Search as: As drawn 2. Query
(1. Query) AND itemno in (1)
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Reaxys ID 908745 View in Reaxys
1/1 CAS Registry Number: 108-56-5 Chemical Name: diethyl oxaloacetate; Diethyl oxalacetate Linear Structure Formula: C2H5OCOCOCH2COOC2H5 Molecular Formula: C8H12O5 Molecular Weight: 188.18 Type of Substance: acyclic InChI Key: JDXYSCUOABNLIR-UHFFFAOYSA-N Note:
O O
O O
O
Substance Label (14) Label References 2
Patent; (5 pag.); CN106854181; (2017); (A) Chinese, View in Reaxys; Patent; Hunan Huateng Pharmaceutical Co., Ltd.; Deng Zeping; Li Shuyun; (5 pag.); CN106749039; (2017); (A) Chinese, View in Reaxys
8d
Fesenko, Anastasia A.; Grigoriev, Mikhail S.; Shutalev, Anatoly D.; Journal of Organic Chemistry; vol. 82; nb. 15; (2017); p. 8085 - 8110, View in Reaxys
9; EZH2-9
Patent; DANA-FARBER CANCER INSTITUTE, INC.; BRADNER, James, E.; QI, Jun; WONG, Kwok, Kin; (329 pag.); WO2016/73956; (2016); (A1) English, View in Reaxys
EZH2-9
Patent; DANA-FARBER CANCER INSTITUTE, INC.; REGENTS OF THE UNIVERSITY OF MINNESOTA; BRADNER, James, E.; BLAZAR, Bruce; FLYNN, Ryan; QI, Jun; (182 pag.); WO2016/73903; (2016); (A1) English, View in Reaxys
2i
Tarigopula, Chandrahas; Thota, Ganesh Kumar; Balamurugan, Rengarajan; European Journal of Organic Chemistry; vol. 2016; nb. 35; (2016); p. 5855 - 5861, View in Reaxys
11a
Patent; MERCK SHARP and DOHME CORP.; BARR, Kenneth, Jay; SCOTT, Mark, E.; THOMPSON, Christopher, F.; ANTHONY, Neville; CAMMARANO, Carolyn, Michelle; BAKSHI, Raman, Kumar; MOHANTY, Subhendu, Kumar; KORAPALA, Chandra, Sekhar; LATTHE, Prashant, R.; KAMBAM, Vyjayanthi, N.; SARKAR, Sujit, Kumar; THATAI, Jayanth, Thiruvellore; WO2015/50798; (2015); (A1) English, View in Reaxys
30
Patent; PURDUE PHARMA L.P.; NI, Chiyou; PARK, Jae, Hyun; SHAO, Bin; ZHOU, Xiaoming; WO2015/94443; (2015); (A1) English, View in Reaxys
2e
Voigt, Benjamin; Mahrwald, Rainer; Chemical Communications; vol. 50; nb. 7; (2014); p. 817 - 819, View in Reaxys
13
Mashaly; El-Gogary; Kosbar; Journal of Heterocyclic Chemistry; vol. 51; nb. 4; (2014); p. 1078 - 1085, View in Reaxys
educt to XI
Metelkina; Russian Journal of Organic Chemistry; vol. 40; nb. 7; (2004); p. 928 - 935, View in Reaxys
3b
Wejroch; Lange; Karolak-Wojciechowska; Sosnicki; Jagodzinski; Kielak; Journal of Heterocyclic Chemistry; vol. 38; nb. 4; (2001); p. 877 - 884, View in Reaxys
3f
Nishiwaki; Nakanishi; Hida; Miwa; Tamura; Hori; Tohda; Ariga; Journal of Organic Chemistry; vol. 66; nb. 22; (2001); p. 7535 - 7538, View in Reaxys
16
Palanki, Moorthy S.S.; Erdman, Paul E.; Goldman, Mark E.; Suto, Carla; Suto, Mark J.; Medicinal Chemistry Research; vol. 10; nb. 1; (2000); p. 19 - 29, View in Reaxys
9b
Drioli, Sara; Nitti, Patrizia; Pitacco, Giuliana; Tossut, Laura; Valentin, Ennio; Tetrahedron Asymmetry; vol. 10; nb. 14; (1999); p. 2713 - 2728, View in Reaxys
Patent-Specific Data (1) Location in Patent References Claim
Patent; Hoechst Celanese Corporation; US4871859; (1989); (A1) English, View in Reaxys
Druglikeness (1) 1 of 1
LogP
0.843
H Bond Donors
0
H Bond Acceptors
5
Rotatable Bonds
7
TPSA
69.67
Lipinski Number
4
Veber Number
2
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Related Structure (5) Related Structure Referenced Com- References pound The following tau- diethyl oxaloacetomers are distate cussed: /BRN= 1909500/
Yakimovich,S.I.; Khrustalev,V.A.; Zhurnal Organicheskoi Khimii; vol. 12; (1976); p. 949 - 956,957 - 963, View in Reaxys; Sugiyama, Shigeru; Fukunaga, Sadao; Kawashiro, Katsuhiro; Hayashi, Hiromu; Bulletin of the Chemical Society of Japan; vol. 65; nb. 8; (1992); p. 2083 - 2085, View in Reaxys Kumler et al.; Journal of Organic Chemistry; vol. 27; (1962); p. 1165, View in Reaxys; Kabachnik; Ioffe; Doklady Chemistry; vol. 165; (1965); p. 1186,1188; Doklady Akademii Nauk SSSR; vol. 165; (1965); p. 1085, View in Reaxys
Nach dem Befund einer Brom-Titration enthaelt eine Loesung des Gleichgewichtsgemisches in Hexan bei Raumtemperatur ca. 75prozent Hydroxybutendisaeure-diaethylester..
Blank et al.; Journal of the Chemical Society; (1955); p. 2190,2192; Bl. Res. Coun. Israel; vol. 3; (1953); p. 101, View in Reaxys
Bestimmung des Enolgehalts der alkohol. Loesung durch Titration mit Kupferacetat.
Dieckmann; Chemische Berichte; vol. 54; (1921); p. 2251, View in Reaxys; Hieber; Chemische Berichte; vol. 54; (1921); p. 912, View in Reaxys
Ueber das KetoEnol-Gleichgewicht s..
Scheiber; Herold; Justus Liebigs Annalen der Chemie; vol. 405; (1914); p. 335, View in Reaxys; Meyer,K. H.; Chemische Berichte; vol. 45; (1912); p. 2861, View in Reaxys; Hantzsch; Chemische Berichte; vol. 48; (1915); p. 1411,1413, View in Reaxys
Derivative (7) Comment (Derivative) 4-Nitro.phenylhydrazon;F: 148grad;1H-NMR (gelb)
References Sucrow; Grosz; Synthetic Communications; vol. 9; (1979); p. 603, View in Reaxys
Na-Salz : Rk. mit Ravoux,J.-P.; Decombe,J.; Bulletin de la Societe Chimique de France; (1969); p. 146 - 153, View in Reaxys N,N-Dimethylaminomethylferrocen-methoiodid -> Bis-(ferrocenylmethyl)-oxalessigsaeure-diaethylester u. Bis(ferrocenylmethyl)-essigsaeureaethylester Mg-Salz: Hay; Australian Journal of Chemistry; vol. 17; (1964); p. 759,760, 763, View in Reaxys (C8H11O5)2Mg*2 H2O, IR-Banden, in Me., A., DMF l., in CHCl3, CCl4, W. wl., S.764 as 2,4-dinitrophenylhydrazone (mp: 147 degree ).
Elkik; J. Recherches Centre nation; vol. 8; (1957); p. 176,182, View in Reaxys
4-nitro-phenylhydrazone (mp: 148.5 degree )
Malachowski; Czornodola; Chemische Berichte; vol. 68; (1935); p. 369, View in Reaxys
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4-chloro-phenylhydrazone (mp: 119-120 degree )
Sah; Lei; Science Reports of National Tsing Hua University, Series A: Mathematical, Physical, and Engineering Sciences; vol. <A> 2; (1933); p. 1,7; Chem. Zentralbl.; vol. 104; nb. II; (1933); p. 1180, View in Reaxys
p-tolylhydrazone (mp: 105-106 degree )
Sah; Lei; Science Reports of National Tsing Hua University, Series A: Mathematical, Physical, and Engineering Sciences; vol. <A> 2; (1933); p. 1,7; Chem. Zentralbl.; vol. 104; nb. II; (1933); p. 1180, View in Reaxys
Boiling Point (15) Boiling Point [°C] Pressure (Boiling Point) [Torr]
Comment (Boiling References Point)
132
20
Nepveu, Francoise; Gaultier, Nicolas; Korber, Nikolaus; Jaud, Joel; Castan, Paule; Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999); nb. 24; (1995); p. 4005 4014, View in Reaxys
71
0.8
Sugiyama, Shigeru; Fukunaga, Sadao; Kawashiro, Katsuhiro; Hayashi, Hiromu; Bulletin of the Chemical Society of Japan; vol. 65; nb. 8; (1992); p. 2083 - 2085, View in Reaxys
64
0.3
Schiering, David W.; Katon, J. E.; Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy; vol. 42; nb. 4; (1986); p. 487 - 498, View in Reaxys
52
0.05
Lewis; Seifert; Organic Preparations and Procedures International; vol. 3; (1971); p. 243, View in Reaxys
76
0.4
Lewis; Seifert; Organic Preparations and Procedures International; vol. 3; (1971); p. 243, View in Reaxys
121 - 122
10
Graf; Liu; Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft; vol. 300; nb. 4; (1967); p. 348 - 353, View in Reaxys
114.5 - 116.5
11
Levas,M.; Levas,E.; Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques; vol. 264; (1967); p. 907 - 910, View in Reaxys
90 - 91
0.3
Gault et al.; Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences; vol. 254; (1962); p. 2993, View in Reaxys
130 - 131
24
Shinohara et al.; Nippon Kagaku Zasshi; vol. 83; (1962); p. 618, View in Reaxys
107 - 108
7
Tschchikwadse; Magidson; Meditsinskaya Promyshlennost SSSR; vol. 14; nb. 10; (1960); p. 24,25, 26; Chem.Abstr.; nb. 6487; (1961), View in Reaxys
132
24
Elkik; J. Recherches Centre nation; vol. 8; (1957); p. 176,182, View in Reaxys
78 - 80
0.5
Smrt et al.; Collection of Czechoslovak Chemical Communications; vol. 20; (1955); p. 285,289, View in Reaxys
83
0.9
Beranek et al.; Collection of Czechoslovak Chemical Communications; vol. 19; (1954); p. 1231,1236, View in Reaxys
85 - 87
1
Riegel et al.; Journal of the American Chemical Society; vol. 68; (1946); p. 2685, View in Reaxys
131 - 132
24
Oel.
Wislicenus; Justus Liebigs Annalen der Chemie; vol. 246; (1888); p. 324, View in Reaxys
Refractive Index (7) Refractive Index Wavelength (Refractive Index) [nm]
Temperature (Refractive Index) [°C]
References
1.4492
589
20
Sucrow; Grosz; Synthetic Communications; vol. 9; (1979); p. 603, View in Reaxys
1.449
589
1.4533
589
Lewis; Seifert; Organic Preparations and Procedures International; vol. 3; (1971); p. 243, View in Reaxys 20
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
Smrt et al.; Collection of Czechoslovak Chemical Communications; vol. 20; (1955); p. 285,289, View in Reaxys
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1.4535
589
20
Beranek et al.; Collection of Czechoslovak Chemical Communications; vol. 19; (1954); p. 1231,1236, View in Reaxys
1.45309
656.3
16.6
Bruehl; Journal fuer Praktische Chemie (Leipzig); vol. <2> 50; (1894); p. 137; Chemische Berichte; vol. 35; (1902); p. 3619, View in Reaxys
1.45614
589
16.6
Bruehl; Journal fuer Praktische Chemie (Leipzig); vol. <2> 50; (1894); p. 137; Chemische Berichte; vol. 35; (1902); p. 3619, View in Reaxys
1.46993
434
16.6
Bruehl; Journal fuer Praktische Chemie (Leipzig); vol. <2> 50; (1894); p. 137; Chemische Berichte; vol. 35; (1902); p. 3619, View in Reaxys
Density (4) 1 of 4
Density [g·cm-3]
1.1324
Reference Temperature [°C]
4
Measurement Temperature [°C]
20
Beranek et al.; Collection of Czechoslovak Chemical Communications; vol. 19; (1954); p. 1231,1236, View in Reaxys 2 of 4
Density [g·cm-3]
1.13 - 1.132
Reference Temperature [°C]
4
Measurement Temperature [°C]
20
v. Auwers; Auffenberg; Chemische Berichte; vol. 51; (1918); p. 1113, View in Reaxys 3 of 4
Density [g·cm-3]
1.1715
Reference Temperature [°C]
4
Measurement Temperature [°C]
16.6
Bruehl; Journal fuer Praktische Chemie (Leipzig); vol. <2> 50; (1894); p. 137; Chemische Berichte; vol. 35; (1902); p. 3619, View in Reaxys 4 of 4
Density [g·cm-3]
1.159
Reference Temperature [°C]
4
Measurement Temperature [°C]
23.5
Wislicenus; Justus Liebigs Annalen der Chemie; vol. 246; (1888); p. 324, View in Reaxys Chromatographic Data (1) Chromatographic References data TLC (Thin layer chromatography)
Tarigopula, Chandrahas; Thota, Ganesh Kumar; Balamurugan, Rengarajan; European Journal of Organic Chemistry; vol. 2016; nb. 35; (2016); p. 5855 - 5861, View in Reaxys
Crystal Property Description (2) Colour & Other Location Properties yellow
Page/Page column 60
References Patent; MERCK SHARP and DOHME CORP.; BARR, Kenneth, Jay; SCOTT, Mark, E.; THOMPSON, Christopher, F.; ANTHONY, Neville; CAMMARANO, Carolyn, Michelle; BAKSHI, Raman, Kumar; MOHANTY, Subhendu, Kumar; KORAPALA, Chandra, Sekhar; LATTHE, Prashant, R.; KAMBAM, Vyjayanthi, N.; SARKAR, Sujit, Kumar; THATAI, Jayanth, Thiruvellore; WO2015/50798; (2015); (A1) English, View in Reaxys Carabateas; Williams; Journal of Heterocyclic Chemistry; vol. 13; (1976); p. 927, View in Reaxys
Further Information (3)
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Description (Further Information)
References
Further information
Ravoux; Decombe; Bulletin de la Societe Chimique de France; (1969); p. 146, View in Reaxys
Further information
Hay; Australian Journal of Chemistry; vol. 17; (1964); p. 759,760, 763, View in Reaxys
Further information
Angulo et al.; Anales de la Real Sociedad Espanola de Fisica y Quimica, Serie B: Quimica; vol. 56; (1960); p. 761, View in Reaxys
NMR Spectroscopy (6) 1 of 6
Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]
400
Location
supporting information
Tarigopula, Chandrahas; Thota, Ganesh Kumar; Balamurugan, Rengarajan; European Journal of Organic Chemistry; vol. 2016; nb. 35; (2016); p. 5855 - 5861, View in Reaxys 2 of 6
Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)
13C
Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]
100
Location
supporting information
Tarigopula, Chandrahas; Thota, Ganesh Kumar; Balamurugan, Rengarajan; European Journal of Organic Chemistry; vol. 2016; nb. 35; (2016); p. 5855 - 5861, View in Reaxys 3 of 6
Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- dimethylsulfoxide-d6 scopy) Original Text (NMR Spectroscopy)
1H NMR (DMSO-d6) 5 = 12.51 (s, 1H), 10.71 (bs, 1H), 7.28 (dt, 1H, J=1. 6, 8. 4Hz), 7.07-7. 10 (m, 3H), 7.01 (dt, 1H, J=1. 6,8. 4 Hz), 6.95 (dd, 1H, J=1. 6, 8. 4 Hz), 4.66 (dd, 1H, J=4. 4,10. 4 Hz), 2.45-2. 49 (m"1H), 2. 36 (s, 6H), 2.28 (s, 3H), 2.13 (dd, 1H, J=10. 4,15. 2 Hz).
Comment (NMR Spectroscopy)
Signals given
Patent; ELAN PHARMACEUTICALS, INC.; WO2003/93245; (2003); (A1) English, View in Reaxys 4 of 6
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- CDCl3 scopy) Vors, Jean-Pierre; Journal of Heterocyclic Chemistry; vol. 27; nb. 3; (1990); p. 579 - 582, View in Reaxys; Sugiyama, Shigeru; Fukunaga, Sadao; Kawashiro, Katsuhiro; Hayashi, Hiromu; Bulletin of the Chemical Society of Japan; vol. 65; nb. 8; (1992); p. 2083 - 2085, View in Reaxys 5 of 6
Description (NMR Spec- NMR troscopy)
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Kolind -Andersen,H. et al.; Bulletin des Societes Chimiques Belges; vol. 84; (1975); p. 341 - 360, View in Reaxys; Sucrow; Grosz; Synthetic Communications; vol. 9; (1979); p. 603, View in Reaxys; Battesti et al.; Bulletin de la Societe Chimique de France; (1974); p. 2214,2217, View in Reaxys; Tsai et al.; Journal of Organic Chemistry; vol. 37; (1972); p. 85, View in Reaxys 6 of 6
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
1H
Yakimovich,S.I.; Khrustalev,V.A.; Zhurnal Organicheskoi Khimii; vol. 12; (1976); p. 949 - 956,957 - 963, View in Reaxys IR Spectroscopy (4) 1 of 4
Description (IR Spectroscopy)
Bands
Solvent (IR Spectroscopy)
neat liquid
Tarigopula, Chandrahas; Thota, Ganesh Kumar; Balamurugan, Rengarajan; European Journal of Organic Chemistry; vol. 2016; nb. 35; (2016); p. 5855 - 5861, View in Reaxys 2 of 4
Description (IR Spectroscopy)
Bands
Solvent (IR Spectroscopy)
neat (no solvent)
Comment (IR Spectroscopy)
1749 - 1736 cm**(-1)
Vors, Jean-Pierre; Journal of Heterocyclic Chemistry; vol. 27; nb. 3; (1990); p. 579 - 582, View in Reaxys 3 of 4
Description (IR Spectroscopy)
IR
Battesti et al.; Bulletin de la Societe Chimique de France; (1974); p. 2214,2217, View in Reaxys 4 of 4
Description (IR Spectroscopy)
Spectrum
Hay; Australian Journal of Chemistry; vol. 17; (1964); p. 759,760, 763, View in Reaxys Mass Spectrometry (3) Description (Mass References Spectrometry) high resolution Tarigopula, Chandrahas; Thota, Ganesh Kumar; Balamurugan, Rengarajan; European Journal of Organmass spectrome- ic Chemistry; vol. 2016; nb. 35; (2016); p. 5855 - 5861, View in Reaxys try (HRMS); electrospray ionisation (ESI); timeof-flight mass spectra (TOFMS); spectrum spectrum; electron impact (EI)
Vors, Jean-Pierre; Journal of Heterocyclic Chemistry; vol. 27; nb. 3; (1990); p. 579 - 582, View in Reaxys Crombie et al.; Journal of the Chemical Society [Section] C: Organic; (1968); p. 137, View in Reaxys
UV/VIS Spectroscopy (4) 1 of 4
Description (UV/VIS Spectroscopy)
UV/VIS
Tsai et al.; Journal of Organic Chemistry; vol. 37; (1972); p. 85, View in Reaxys 2 of 4
Description (UV/VIS Spectroscopy)
Absorption maxima
Cantlon,I.J. et al.; Tetrahedron; vol. 15; (1961); p. 46 - 52, View in Reaxys 3 of 4
Description (UV/VIS Spectroscopy)
Absorption maxima
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Solvent (UV/VIS Spectroscopy)
ethanol
Comment (UV/VIS Spectroscopy)
UV-Absorption.Spektrum:UV-Absorption des Natriumsalzes in CHCl3 und in wss.Na2CO3.
Hantzsch; Chemische Berichte; vol. 48; (1915); p. 1411,1413, View in Reaxys 4 of 4
Description (UV/VIS Spectroscopy)
Spectrum
Baly; Desch; Journal of the Chemical Society; vol. 87; (1905); p. 781, View in Reaxys Medchem (8) 1 of 8
Bioassay Category
In Vitro (Efficacy)
Cells/Cell Lines
SK-N-BE(2)-M17 cell line
Substance RN
908745View in Reaxys
Substance Name
diethyl oxaloacetate
Substance Dose
5 mM
Measurement Parameter
% increase
Qualitative value
Active
Measurement pX
2.3
Concomitants: Compound RN
3590305
Concomitants: Compound role
COM
Delic, Vedad; Griffin, Jeddidiah W. D.; Zivkovic, Sandra; Zhang, Yumeng; Phan, Tam-Anh; Gong, Henry; Chaput, Dale; Reynes, Christian; Dinh, Vinh B.; Cruz, Josean; Cvitkovic, Eni; Placides, Devon; Frederic, Ernide; Mirzaei, Hamed; Stevens, Stanley M.; Jinwal, Umesh; Lee, Daniel C.; Bradshaw, Patrick C.; NeuroMolecular Medicine; vol. 19; nb. 2-3; (2017); p. 322 - 344, View in Reaxys 2 of 8
Bioassay Category
In Vitro (Efficacy)
Cells/Cell Lines
SK-N-BE(2)-M17 cell line
Substance RN
908745View in Reaxys
Substance Name
diethyl oxaloacetate
Substance Dose
1 mM
Measurement Parameter
% increase
Qualitative value
Active
Statistical sgnificance (Qualitative)
S
Measurement pX
3
Concomitants: Compound RN
3590305
Concomitants: Compound role
COM
Delic, Vedad; Griffin, Jeddidiah W. D.; Zivkovic, Sandra; Zhang, Yumeng; Phan, Tam-Anh; Gong, Henry; Chaput, Dale; Reynes, Christian; Dinh, Vinh B.; Cruz, Josean; Cvitkovic, Eni; Placides, Devon; Frederic, Ernide; Mirzaei, Hamed; Stevens, Stanley M.; Jinwal, Umesh; Lee, Daniel C.; Bradshaw, Patrick C.; NeuroMolecular Medicine; vol. 19; nb. 2-3; (2017); p. 322 - 344, View in Reaxys 3 of 8
Substance Effect
Antioxidant
Bioassay Category
In Vitro (Efficacy)
Cells/Cell Lines
SK-N-BE(2)-M17 cell line
Substance RN
908745View in Reaxys
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Substance Name
diethyl oxaloacetate
Substance Dose
1 mM
Measurement Parameter
% decrease
Qualitative value
Active
Statistical sgnificance (Qualitative)
S
Measurement pX
3
Concomitants: Compound RN
3590305
Concomitants: Compound role
COM
Delic, Vedad; Griffin, Jeddidiah W. D.; Zivkovic, Sandra; Zhang, Yumeng; Phan, Tam-Anh; Gong, Henry; Chaput, Dale; Reynes, Christian; Dinh, Vinh B.; Cruz, Josean; Cvitkovic, Eni; Placides, Devon; Frederic, Ernide; Mirzaei, Hamed; Stevens, Stanley M.; Jinwal, Umesh; Lee, Daniel C.; Bradshaw, Patrick C.; NeuroMolecular Medicine; vol. 19; nb. 2-3; (2017); p. 322 - 344, View in Reaxys 4 of 8
Substance Effect
Cytotoxic
Bioassay Category
In Vitro (Efficacy)
Cells/Cell Lines
SK-N-BE(2)-M17 cell line
Substance RN
908745View in Reaxys
Substance Name
diethyl oxaloacetate
Measurement Parameter
% decrease
Measurement Object
Viability
Qualitative value
Active
Concomitants: Compound RN
3590305
Concomitants: Compound role
COM
Delic, Vedad; Griffin, Jeddidiah W. D.; Zivkovic, Sandra; Zhang, Yumeng; Phan, Tam-Anh; Gong, Henry; Chaput, Dale; Reynes, Christian; Dinh, Vinh B.; Cruz, Josean; Cvitkovic, Eni; Placides, Devon; Frederic, Ernide; Mirzaei, Hamed; Stevens, Stanley M.; Jinwal, Umesh; Lee, Daniel C.; Bradshaw, Patrick C.; NeuroMolecular Medicine; vol. 19; nb. 2-3; (2017); p. 322 - 344, View in Reaxys 5 of 8
Substance Effect
Antioxidant
Bioassay Category
In Vitro (Efficacy)
Cells/Cell Lines
SH-SY5Y cell line
Substance RN
908745View in Reaxys
Substance Name
diethyl oxaloacetate
Measurement Parameter
% decrease
Qualitative value
Not active
Measurement pX
1
Concomitants: Compound RN
11335883
Concomitants: Compound role
COM
Delic, Vedad; Griffin, Jeddidiah W. D.; Zivkovic, Sandra; Zhang, Yumeng; Phan, Tam-Anh; Gong, Henry; Chaput, Dale; Reynes, Christian; Dinh, Vinh B.; Cruz, Josean; Cvitkovic, Eni; Placides, Devon; Frederic, Ernide; Mirzaei, Hamed; Stevens, Stanley M.; Jinwal, Umesh; Lee, Daniel C.; Bradshaw, Patrick C.; NeuroMolecular Medicine; vol. 19; nb. 2-3; (2017); p. 322 - 344, View in Reaxys
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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6 of 8
Bioassay Category
In Vitro (Efficacy)
Cells/Cell Lines
SH-SY5Y cell line
Substance RN
908745View in Reaxys
Substance Name
diethyl oxaloacetate
Measurement Parameter
% increase
Qualitative value
Active
Concomitants: Compound RN
3590305
Concomitants: Compound role
COM
Delic, Vedad; Griffin, Jeddidiah W. D.; Zivkovic, Sandra; Zhang, Yumeng; Phan, Tam-Anh; Gong, Henry; Chaput, Dale; Reynes, Christian; Dinh, Vinh B.; Cruz, Josean; Cvitkovic, Eni; Placides, Devon; Frederic, Ernide; Mirzaei, Hamed; Stevens, Stanley M.; Jinwal, Umesh; Lee, Daniel C.; Bradshaw, Patrick C.; NeuroMolecular Medicine; vol. 19; nb. 2-3; (2017); p. 322 - 344, View in Reaxys 7 of 8
Substance Effect
Antineoplastic
Bioassay Category
Toxicity/Safety Pharmacology
Cells/Cell Lines
SH-SY5Y cell line
Substance RN
908745View in Reaxys
Substance Name
diethyl oxaloacetate
Measurement Parameter
% decrease
Measurement Object
Viability
Qualitative value
Active
Delic, Vedad; Griffin, Jeddidiah W. D.; Zivkovic, Sandra; Zhang, Yumeng; Phan, Tam-Anh; Gong, Henry; Chaput, Dale; Reynes, Christian; Dinh, Vinh B.; Cruz, Josean; Cvitkovic, Eni; Placides, Devon; Frederic, Ernide; Mirzaei, Hamed; Stevens, Stanley M.; Jinwal, Umesh; Lee, Daniel C.; Bradshaw, Patrick C.; NeuroMolecular Medicine; vol. 19; nb. 2-3; (2017); p. 322 - 344, View in Reaxys 8 of 8
Bioassay Category
In Vitro (Efficacy)
Cells/Cell Lines
SK-N-BE(2)-M17 cell line
Substance RN
908745View in Reaxys
Substance Name
diethyl oxaloacetate
Substance Dose
1 mM
Measurement Parameter
% increase
Qualitative value
Active
Measurement pX
3
Concomitants: Compound RN
1724615
Concomitants: Compound name
D-glucose
Concomitants: Compound role
COM
Delic, Vedad; Griffin, Jeddidiah W. D.; Zivkovic, Sandra; Zhang, Yumeng; Phan, Tam-Anh; Gong, Henry; Chaput, Dale; Reynes, Christian; Dinh, Vinh B.; Cruz, Josean; Cvitkovic, Eni; Placides, Devon; Frederic, Ernide; Mirzaei, Hamed; Stevens, Stanley M.; Jinwal, Umesh; Lee, Daniel C.; Bradshaw, Patrick C.; NeuroMolecular Medicine; vol. 19; nb. 2-3; (2017); p. 322 - 344, View in Reaxys
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