Bioactivities (77)
Reactions (37)
Substances (1)
Structure
Targets (16)
Citations (21)
N° of preparations All Preps | All Reactions
Structure/Compound Data Chemical Name: 1-phenylmethylpiperazine
37 prep out of 2857 reactions.
Reaxys Registry Number: 141624
CAS Registry Number: 2759-28-6 Type of Substance: heterocyclic Molecular Formula: C11H16N2
Linear Structure Formula: NH(CH2)4NCH2C6H5
Molecular Weight: 176.261 InChI Key: IQXXEPZFOOTTBA-UHFFFAOYSA-N
1
Synthesize | Hide Details
Available Data
Target
N° of ref.
Druglikeness
Bioactivity
Identification Physical Data (44) Spectra (40)
Show Targets
1728
Find similar Chemical Names and Synonyms 1-phenylmethylpiperazine, 1 -benzylpiperazine Druglikeness Bioactivity In vitro: Efficacy (33) Quantitative Results pX
Parameter
4.96
IC50
Value (qual)
Value (quant)
Unit
10901.5
nM
Action on Target
Target
Tissue/Organ
Cell
Bioassay
Dose
Effect
Reference (expand all/collapse all)
Sigma receptor [guinea pig]:Wild
Brain
Binding
Patent: US6057371 A1, ...
Title/Abstract Full Text Show Details
Sigma receptor [guinea pig]:Wild
Brain
Binding
Journal of Medicinal Che...
Title/Abstract Full Text View citing articles Show Details
Virginia Commonwealth University
Patent: US6057371 A1, 2000 ; Title/Abstract Full Text Show Details
4.98
Ki
10480
nM
Glennon; Yousif; Ismaiel; El-Ashmawy; Herndon; Fischer; Server; Howie
Journal of Medicinal Chemistry, 1991 , vol. 34, # 12 p. 3360 - 3365 Title/Abstract Full Text View citing articles Show Details
1
Ki
>
10000
nM
5hydroxytryptamine receptor 2A [Rattus norvegicus]:Wild
frontal cortex
Binding
Journal of Medicinal Che...
Title/Abstract Full Text Show Details
frontal cortex
Binding
Journal of Medicinal Che...
Title/Abstract Full Text Show Details
brain cortex
Binding
European Journal of Phar...
Title/Abstract Full Text Show Details
In Vitro (others)
Journal of Pharmacology ...
Title/Abstract Full Text View citing articles Show Details
Herndon; Ismaiel; Ingher; Teitler; Glennon
Journal of Medicinal Chemistry, 1992 , vol. 35, # 26 p. 4903 - 4910 Title/Abstract Full Text Show Details
1
Ki
>
10000
nM
5hydroxytryptamine receptor 2C [Rattus norvegicus]:Wild
Herndon; Ismaiel; Ingher; Teitler; Glennon
Journal of Medicinal Chemistry, 1992 , vol. 35, # 26 p. 4903 - 4910 Title/Abstract Full Text Show Details
6
IC50
>
1000
nM
5hydroxytryptamine receptor 3A [Rattus norvegicus]:Wild
Glennon; Ismaiel; McCarthy; Peroutka
European Journal of Pharmacology, 1989 , vol. 168, # 3 p. 387 - 392 Title/Abstract Full Text Show Details
4
EC50
100
µM
Partilla, John S.; Dempsey, Allison G.; Nagpal, Ameet S.; Blough, Bruce E.; Baumann, Michael H.; Rothman, Richard B.
Journal of Pharmacology and Experimental Therapeutics, 2006 , vol. 319, # 1 p. 237 - 246 Title/Abstract Full Text View citing articles Show Details
4
EC50
100
µM
In Vitro (others)
Journal of Pharmacology ...
Title/Abstract Full Text View citing articles Show Details
Partilla, John S.; Dempsey, Allison G.; Nagpal, Ameet S.; Blough, Bruce E.; Baumann, Michael H.; Rothman, Richard B.
Journal of Pharmacology and Experimental Therapeutics, 2006 , vol. 319, # 1 p. 237 - 246 Title/Abstract Full Text View citing articles Show Details
4
IC50
100
µM
Synaptic vesicular amine transporter:Wild
In Vitro (others)
Journal of Pharmacology ...
Title/Abstract Full Text View citing articles Show Details
Partilla, John S.; Dempsey, Allison G.; Nagpal, Ameet S.; Blough, Bruce E.; Baumann, Michael H.; Rothman, Richard B.
Journal of Pharmacology and Experimental Therapeutics, 2006 , vol. 319, # 1 p. 237 - 246 Title/Abstract Full Text View citing articles Show Details
4
IC50
100
µM
Synaptic vesicular amine transporter:Wild
In Vitro (others)
Journal of Pharmacology ...
Title/Abstract Full Text View citing articles Show Details
Partilla, John S.; Dempsey, Allison G.; Nagpal, Ameet S.; Blough, Bruce E.; Baumann, Michael H.; Rothman, Richard B.
Journal of Pharmacology and Experimental Therapeutics, 2006 , vol. 319, # 1 p. 237 - 246 Title/Abstract Full Text View citing articles Show Details
1
IC50
>
100
µM
HL 60
In Vitro (others)
Cell Death
Patent: WO2008/134474 ...
Title/Abstract Full Text Show Details
HERGENROTHER, Paul J.; PUTT, Karson S.; SANDHORST, Joseph S.; PETERSON, Quinn P.; FAKO, Valerie
Patent: WO2008/134474 A2, 2008 ; Title/Abstract Full Text Show Details
1
EC50
>
50
µM
Procaspase-3:Wild
In Vitro (others)
Patent: WO2008/134474 ...
Title/Abstract Full Text Show Details
HERGENROTHER, Paul J.; PUTT, Karson S.; SANDHORST, Joseph S.; PETERSON, Quinn P.; FAKO, Valerie
Patent: WO2008/134474 A2, 2008 ; Title/Abstract Full Text Show Details
1
EC50
>
50
µM
Procaspase-3:Wild
Enzymology
Patent: WO2006/128173 ...
stimulation
Title/Abstract Full Text Show Details
Enzymology stimulation
Nature Chemical Biology,...
Title/Abstract Full Text View citing articles Show Details
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Patent: WO2006/128173 A2, 2006 ; Title/Abstract Full Text Show Details
1
EC50
>
50
µM
Procaspase-3:Wild
Putt, Karson S.; Chen, Grace W.; Pearson, Jennifer M.; Sandhorst, Joseph S.; Hoagland, Martin S.; Kwon, Jung-Taek; Hwang, Soon-Kyung; Jin, Hua; Churchwell, Mona I.; Cho, MyungHaing; Doerge, Daniel R.; Helferich, William G.; Hergenrother, Paul J.
Nature Chemical Biology, 2006 , vol. 2, # 10 p. 543 - 550 Title/Abstract Full Text View citing articles Show Details
6.21
IC50
6.2E-07
M
In Vitro (others)
European Journal of Phar...
Title/Abstract Full Text View citing articles Show Details
In Vitro (others)
European Journal of Phar...
Title/Abstract Full Text View citing articles Show Details
In Vitro (others)
European Journal of Phar...
Title/Abstract Full Text View citing articles Show Details
In Vitro (others)
European Journal of Phar...
Title/Abstract Full Text View citing articles Show Details
In Vitro (others)
European Journal of Phar...
Title/Abstract Full Text View citing articles Show Details
Nagai, Fumiko; Nonaka, Ryouichi; Satoh Hisashi Kamimura, Kanako
European Journal of Pharmacology, 2007 , vol. 559, # 2-3 p. 132 - 137 Title/Abstract Full Text View citing articles Show Details
4.7
IC50
2E-05
M
Nagai, Fumiko; Nonaka, Ryouichi; Satoh Hisashi Kamimura, Kanako
European Journal of Pharmacology, 2007 , vol. 559, # 2-3 p. 132 - 137 Title/Abstract Full Text View citing articles Show Details
5.72
IC50
1.9E-06
M
Nagai, Fumiko; Nonaka, Ryouichi; Satoh Hisashi Kamimura, Kanako
European Journal of Pharmacology, 2007 , vol. 559, # 2-3 p. 132 - 137 Title/Abstract Full Text View citing articles Show Details
7.17
EC50
6.8E-08
M
Nagai, Fumiko; Nonaka, Ryouichi; Satoh Hisashi Kamimura, Kanako
European Journal of Pharmacology, 2007 , vol. 559, # 2-3 p. 132 - 137 Title/Abstract Full Text View citing articles Show Details
6.22
EC50
6E-07
M
Nagai, Fumiko; Nonaka, Ryouichi; Satoh Hisashi Kamimura, Kanako
European Journal of Pharmacology, 2007 , vol. 559, # 2-3 p. 132 - 137 Title/Abstract Full Text View citing articles Show Details
1
Ki
>
10000
nM
Radioligand (/ligand)
Sigma non-opioid intracellular receptor 1 [guinea pig]:Wild
Bioorganic and Medicinal...
Title/Abstract Full Text View citing articles Show Details
Ablordeppey, Seth Y.; Fischer, James B.; Glennon, Richard A.
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 8 p. 2105 - 2111 Title/Abstract Full Text View citing articles Show Details
7.21
EC50
=
62
nM
sodium-dependent dopamine transporter [rattus norvegicus]:Wild
Current Topics in Medici...
Title/Abstract Full Text View citing articles Show Details
Rothman, Richard B.; Baumann, Michael H.
Current Topics in Medicinal Chemistry, 2006 , vol. 6, # 17 p. 1845 - 1859 Title/Abstract Full Text View citing articles Show Details
pX
Parameter
Value (qual)
Value (quant)
Unit
Action on Target
Target
Tissue/Organ
Cell
Bioassay
Dose
Effect
Reference (expand all/collapse all)
5.22
EC50
=
6050
nM
Sodium-dependent serotonin transporter [Rattus norvegicus]:Wild
Current Topics in Medici...
Title/Abstract Full Text View citing articles Show Details
Rothman, Richard B.; Baumann, Michael H.
Current Topics in Medicinal Chemistry, 2006 , vol. 6, # 17 p. 1845 - 1859 Title/Abstract Full Text View citing articles Show Details
6.76
EC50
=
175
nM
Sodium-dependent dopamine transporter [Rattus norvegicus]:Wild
Current Topics in Medici...
Title/Abstract Full Text View citing articles Show Details
Rothman, Richard B.; Baumann, Michael H.
Current Topics in Medicinal Chemistry, 2006 , vol. 6, # 17 p. 1845 - 1859 Title/Abstract Full Text View citing articles Show Details
%
=
44
%
Cholecystokinin receptor [human]:Wild
MESSA/Dx5
Cytotoxic
B KOR CHEM SOC, 2009 , ...
Title/Abstract Full Text Show Details
Young Taek Han; Eun Kyung Kim; Eun Ae Kim; Eun Seon Kim; Dae Kyong Kim; Young-Ger Suh; Kyung Hoon Min
B KOR CHEM SOC, 2009 , vol. 30, # 4 p. 779 - 780 Title/Abstract Full Text Show Details
IC50
ND
Multidrug resistance protein 1 [human]:Wild
B KOR CHEM SOC, 2009 , ...
Title/Abstract Full Text Show Details
MESSA/Dx5
Young Taek Han; Eun Kyung Kim; Eun Ae Kim; Eun Seon Kim; Dae Kyong Kim; Young-Ger Suh; Kyung Hoon Min
B KOR CHEM SOC, 2009 , vol. 30, # 4 p. 779 - 780 Title/Abstract Full Text Show Details
5.6
IC50
>
2500
nM
Multidrug resistance protein 1 [human]:Wild
B KOR CHEM SOC, 2009 , ...
Title/Abstract Full Text Show Details
MESSA/Dx5
Young Taek Han; Eun Kyung Kim; Eun Ae Kim; Eun Seon Kim; Dae Kyong Kim; Young-Ger Suh; Kyung Hoon Min
B KOR CHEM SOC, 2009 , vol. 30, # 4 p. 779 - 780 Title/Abstract Full Text Show Details
%
=
79.01
%
Inhibitor
arachidonate 15lipoxygenase [human]:Wild
inhibitory activity
Journal of Medicinal Che...
Title/Abstract Full Text View citing articles Show Details
Eleftheriadis, Nikolaos; Neochoritis, Constantinos G.; Leus, Niek G. J.; Van Der Wouden, Petra E.; Dömling, Alexander; Dekker, Frank J.
Journal of Medicinal Chemistry, 2015 , vol. 58, # 19 p. 7850 - 7862 Title/Abstract Full Text View citing articles Show Details
1
% Inhibition
Not active
Inhibitor
Cholinesterase [Human]:Wild
serum
40 μM
ChemMedChem, 2016 , p. 1...
Title/Abstract Full Text View citing articles Show Details
Prati, Federica; Bergamini, Christian; Fato, Romana; Soukup, Ondrej; Korabecny, Jan; Andrisano, Vincenza; Bartolini, Manuela; Bolognesi, Maria Laura
ChemMedChem, 2016 , p. 1284 - 1295 Title/Abstract Full Text View citing articles Show Details
1
% Inhibition
Not active
Inhibitor
acetylcholinesterase [Human]:Wild
40 100 μM
ChemMedChem, 2016 , p. 1...
Title/Abstract Full Text View citing articles Show Details
Prati, Federica; Bergamini, Christian; Fato, Romana; Soukup, Ondrej; Korabecny, Jan; Andrisano, Vincenza; Bartolini, Manuela; Bolognesi, Maria Laura
ChemMedChem, 2016 , p. 1284 - 1295 Title/Abstract Full Text View citing articles Show Details
5.71
IC50
1.97
μM
Inhibitor
Focal adhesion kinase 1:Wild
Sun, Juan; Ren, Shen-Zhen; Lu, Xiao-Yuan; Li, Jing-Jing; Shen, Fa-Qian; Xu, Chen; Zhu, Hai-Liang
Bioorganic and Medicinal Chemistry, 2017 , vol. 25, # 9 p. 2593 - 2600 Title/Abstract Full Text View citing articles Show Details
Qualitative Information 1 of 4
Assay Description
Effect : bacterial resistance; inhibition of Target : Escherichia coli 3-AG100MKX
Bioorganic and Medicinal...
Title/Abstract Full Text View citing articles Show Details
Bioassay : 3-AG100MKX: AcrAB-overexpressing gyrA mutant derived from AG100MKX (AG100 marA::Kmr); AcrAB: efflux pump; reference comp.: Phe-Arg-β-naphtylamide cells incubated with levofloxacin in presence of title comp.; levofloxacin MIC determined by spectrofotometric assay
2 of 4
3 of 4
4 of 4
Results
title comp. conc. to reduce levofloxacin MIC by 4-fold was 250 μg/ml
Citation
Bohnert, Juergen A.; Kern, Winfried V.
Antimicrobial Agents and Chemotherapy, 2005 , vol. 49, # 2 p. 849 - 852 Title/Abstract Full Text View citing articles Show Details
Target
acetylcholinesterase [human]:Wild
Assay Description
Effect : |enzyme; inhib. of Bioassay : AChE: acetylcholinesterase AChE treated with title comp.; pH 7.4; acetylcholine used as substrate; AChE activity determined at 15-s intervals for 2 min
Citation
Harel, Michal; Hyatt, Janice L.; Brumshtein, Boris; Morton, Christopher L.; Yoon, Kyoung Jin P.; Wadkins, Randy M.; Silman, Israel; Sussman, Joel L.; Potter, Philip M.
Molecular Pharmacology, 2005 , vol. 67, # 6 p. 1874 - 1881 Title/Abstract Full Text View citing articles Show Details
Assay Description
Effect : |transmitter releasing Target : brain cortex synaptosomes of Sprague-Dawley rat Bioassay : non-displaceable tritium measured in the presence of tyramine; positive control: methamphetamine (EC50 = 7.9E-7 M); cocaine: no effect; 5-HT: serotonin synaptosomes pre-loaded with <3H>5-HT added to plate containing title comp.; 30 min at 25 deg C; scintillation counted
Citation
Nagai, Fumiko; Nonaka, Ryouichi; Satoh Hisashi Kamimura, Kanako
European Journal of Pharmacology, 2007 , vol. 559, # 2-3 p. 132 - 137 Title/Abstract Full Text View citing articles Show Details
Target
Caspase-3:Wild
Assay Description
In vitro ability of the compound (40 uM) to activate procaspase-3 recombinantly expressed in Escherichia coli using Ac-Asp-Val-Asp-p-nitroaniline substrate upon incubation for 2 h at 37 degree C; Inactive
Citation
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Patent: WO2006/128173 A2, 2006 ; Title/Abstract Full Text Show Details
In vivo: Animal Model (2) Quantitative Results pX
Parameter
Value (qual)
% Inhibition
Value (quant)
Unit
43
%
Action on Target
Animal Model
Biological Species
Route of administration
Macaca mulatta
intravenous administration
Dose
Dosing regimen
Qualitative Information 1 of 1
Biological material
Macaca mulatta
Assay Description
Effect : reinstate response to amphetamine self-administration behaviour peak response rates induced by an amphetamine prime = 0.51 responses/s
Results
peak response rate 69 percent
Citation
McClung, Jessica; Fantegrossi, William; Howell, Leonard L.
Psychopharmacology, 2010 , vol. 210, # 1 p. 75 - 83 Title/Abstract Full Text View citing articles Show Details
Effect
Reference (expand all/collapse all) Psychopharmacology, 2010...
Title/Abstract Full Text View citing articles Show Details
Metabolism (7) Quantitative Results pX
Parameter
Value (qual)
Value (quant)
Unit
Ue (%)
=
6.7
%
Action on Target
Target
Tissue/Organ
Cell
Cell fraction
Substrate /Carried Molecule
Dose
Reference (expand all/collapse all) Clinical Toxicology, 201...
Title/Abstract Full Text View citing articles Show Details
Schep, Leo J.; Slaughter, Robin J.; Vale, J. Allister; Beasley, D. Michael G.; Gee, Paul
Clinical Toxicology, 2011 , vol. 49, # 3 p. 131 - 141 Title/Abstract Full Text View citing articles Show Details
Ue (%)
=
33.7
%
Clinical Toxicology, 201...
Title/Abstract Full Text View citing articles Show Details
Schep, Leo J.; Slaughter, Robin J.; Vale, J. Allister; Beasley, D. Michael G.; Gee, Paul
Clinical Toxicology, 2011 , vol. 49, # 3 p. 131 - 141 Title/Abstract Full Text View citing articles Show Details
Tmax
=
75
minute
Clinical Toxicology, 201...
Title/Abstract Full Text View citing articles Show Details
Schep, Leo J.; Slaughter, Robin J.; Vale, J. Allister; Beasley, D. Michael G.; Gee, Paul
Clinical Toxicology, 2011 , vol. 49, # 3 p. 131 - 141 Title/Abstract Full Text View citing articles Show Details
t1/2 el
=
6.2
minute
Clinical Toxicology, 201...
Title/Abstract Full Text View citing articles Show Details
Schep, Leo J.; Slaughter, Robin J.; Vale, J. Allister; Beasley, D. Michael G.; Gee, Paul
Clinical Toxicology, 2011 , vol. 49, # 3 p. 131 - 141 Title/Abstract Full Text View citing articles Show Details
Tmax
=
5
minute
Clinical Toxicology, 201...
Title/Abstract Full Text View citing articles Show Details
Schep, Leo J.; Slaughter, Robin J.; Vale, J. Allister; Beasley, D. Michael G.; Gee, Paul
Clinical Toxicology, 2011 , vol. 49, # 3 p. 131 - 141 Title/Abstract Full Text View citing articles Show Details
t1/2 el
=
44
hour
Clinical Toxicology, 201...
Title/Abstract Full Text View citing articles Show Details
Schep, Leo J.; Slaughter, Robin J.; Vale, J. Allister; Beasley, D. Michael G.; Gee, Paul
Clinical Toxicology, 2011 , vol. 49, # 3 p. 131 - 141 Title/Abstract Full Text View citing articles Show Details
t1/2 el
=
5.5
hour
Clinical Toxicology, 201...
Title/Abstract Full Text View citing articles Show Details
Schep, Leo J.; Slaughter, Robin J.; Vale, J. Allister; Beasley, D. Michael G.; Gee, Paul
Clinical Toxicology, 2011 , vol. 49, # 3 p. 131 - 141 Title/Abstract Full Text View citing articles Show Details
Pharmacokinetic (1) Quantitative Results pX
Parameter
Value (qual)
Value (quant)
Unit
Biological Species
Route of administration
Ue (%)
=
12.5
%
Human
oral administration
Dose
Dosing regimen
Population
Reference (expand all/collapse all) Clinical Toxicology, 201...
Title/Abstract Full Text View citing articles Show Details
Schep, Leo J.; Slaughter, Robin J.; Vale, J. Allister; Beasley, D. Michael G.; Gee, Paul
Clinical Toxicology, 2011 , vol. 49, # 3 p. 131 - 141 Title/Abstract Full Text View citing articles Show Details
Toxicity/Safety Pharmacology (34) Quantitative Results pX
Parameter
Value (qual)
Value (quant)
Unit
1
IC50
>
100
µM
Action on Target
Target
Tissue/Organ
Cell
Bioassay
Dose
Effect
Reference (expand all/collapse all)
HL 60
Cell/tumor cell: proliferation/viability/growth
Patent: WO2006/128173 ...
Title/Abstract Full Text Show Details
HL 60
Cell/tumor cell: proliferation/viability/growth
Nature Chemical Biology,...
Title/Abstract Full Text View citing articles Show Details
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Patent: WO2006/128173 A2, 2006 ; Title/Abstract Full Text Show Details
1
IC50
>
100
µM
Putt, Karson S.; Chen, Grace W.; Pearson, Jennifer M.; Sandhorst, Joseph S.; Hoagland, Martin S.; Kwon, Jung-Taek; Hwang, Soon-Kyung; Jin, Hua; Churchwell, Mona I.; Cho, Myung-Haing; Doerge, Daniel R.; Helferich, William G.; Hergenrother, Paul J.
Nature Chemical Biology, 2006 , vol. 2, # 10 p. 543 - 550 Title/Abstract Full Text View citing articles Show Details
Activity
@
Journal of medicinal che...
Title/Abstract Full Text Show Details
J. CYMERMAN CRAIG; M. E. TATE; G. P. WARWICK; W. P. ROGERS Journal of medicinal chemistry, 1960 , vol. 2, # 6 p. 681 - 685 Title/Abstract Full Text Show Details 2.56
Foldincrease
Active
2.77 mM
Apoptotic
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
3.06
Foldincrease
Active
0.88 mM
Apoptotic
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
2.78
Foldincrease
Active
1.66 mM
Apoptotic
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
2.67
EC50
2.15
mM
liver cell
Hepatotoxic
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
EC5
0.32
mM
liver cell
Hepatotoxic
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
Emax(%)
104.3
%
liver cell
Hepatotoxic
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
2.18
EC50
6.6
mM
HepaRG
Cytotoxic
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
EC5
3.1
mM
HepaRG
Cytotoxic
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
Emax(%)
97.45
%
HepaRG
Cytotoxic
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
%
5
%
HepaRG
3.097 mM
Cytotoxic
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
EC20
0.88
mM
liver cell
Hepatotoxic
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
2.6
EC40
1.66
mM
liver cell
Hepatotoxic
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
2.73
EC60
2.77
mM
liver cell
Hepatotoxic
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
3.06
% increase
Active
liver cell
0.88 mM
Oxidative Stress
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
2.78
% increase
Active
liver cell
1.66 mM
Oxidative Stress
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
2.56
% increase
Active
liver cell
2.77 mM
Oxidative Stress
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
3.06
% decrease
Active
liver cell
0.88 mM
Oxidative Stress
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
pX
Parameter
Value (qual)
2.78
% decrease
Active
Value (quant)
Unit
Action on Target
Target
Tissue/Organ
Cell liver cell
Bioassay
Dose
Effect
Reference (expand all/collapse all)
1.66 mM
Oxidative Stress
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
2.56
% decrease
Active
liver cell
2.77 mM
Oxidative Stress
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
3.06
% decrease
Active
liver cell
0.88 mM
Oxidative Stress
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
2.78
% decrease
Active
liver cell
1.66 mM
Oxidative Stress
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
2.56
% decrease
Active
liver cell
2.77 mM
Oxidative Stress
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
3.06
% increase
Active
liver cell
0.88 mM
Oxidative Stress
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
2.78
% increase
Active
liver cell
1.66 mM
Oxidative Stress
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
2.56
% increase
Active
liver cell
2.77 mM
Oxidative Stress
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
3.06
% decrease
Active
liver cell
0.88 mM
Apoptotic
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
2.78
% decrease
Active
liver cell
1.66 mM
Apoptotic
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
2.56
% decrease
Active
liver cell
2.77 mM
Apoptotic
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
2.56
% decrease
Active
liver cell
2.77 mM
Apoptotic
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
2.78
% decrease
Active
liver cell
1.66 mM
Apoptotic
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
3.06
% decrease
Active
liver cell
0.88 mM
Apoptotic
Archives of Toxicology, ...
Title/Abstract Full Text View citing articles Show Details
Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena
Archives of Toxicology, 2017 , vol. 91, # 3 p. 1413 - 1430 Title/Abstract Full Text View citing articles Show Details
Identification Physical Data Spectra