2-(Methylamino)-1-phenylpropan-1-ol (Eph) to 2-(Methylamino)-1-phenylpropan-1-one (MCAT)

Page 1

Query Query HO

1. Query

HN

Results

Date

6 reactions in Reaxys

2017-11-28 21h:45m:52s (EST)

O

HN

Search as: As drawn, No salts, No mixtures

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2017-11-28 21:47:20


OH

H N

O

H N

Rx-ID: 4459789 View in Reaxys 1/6 Yield

Conditions & References

90 %

With trifluoroacetic acid, 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in dimethyl sulfoxide, Time= 2.5h, Ambient temperature Frigerio, Marco; Santagostino, Marco; Sputore, Simona; Palmisano, Giovanni; Journal of Organic Chemistry; vol. 60; nb. 22; (1995); p. 7272 - 7276 View in Reaxys

80 %

With iron vanadate, urea hydrogen peroxide adduct in acetonitrile, Time= 3h, T= 50 °C , Catalytic behavior, chemoselective reaction Heydari, Akbar; Sheykhan, Mehdi; Sadeghi, Masoud; Radfar, Iman; Inorganic and Nano-Metal Chemistry; vol. 47; nb. 2; (2017); p. 248 - 255 View in Reaxys

H N

H

OH

H N

H

O

H

Rx-ID: 333850 View in Reaxys 2/6 Yield 72 %

Conditions & References With tert.-butylhydroperoxide, C20H22CoN12O6S3 in water, Time= 0.166667h, T= 100 °C , Microwave irradiation, Catalytic behavior, Reagent/catalyst Frija, Luís M.T.; Alegria, Elisabete C.B.A.; Sutradhar, Manas; Cristiano, M. Lurdes S.; Ismael, Amin; Kopylovich, Maximilian N.; Pombeiro, Armando J.L.; Journal of Molecular Catalysis A: Chemical; vol. 425; (2016); p. 283 - 290 View in Reaxys With chromium(VI) oxide Patent; Parke, Davis and Co.; US2802865; (1954) View in Reaxys Stage 1: With sodium dichromate, sulfuric acid in water, Time= 12.3333h, T= 15 - 20 °C Stage 2: With sodium hydroxide in water, toluene, T= 20 °C , pH= 10.5, Further stages Hitesh Kumar, Borkatte N.; Murugesan, Velayudham; Prakasam, Tangirala; Srinivasan, Pathangi S.; Ramana, Devalla V.; Tetrahedron Asymmetry; vol. 20; nb. 24; (2009); p. 2773 - 2779 View in Reaxys With potassium permanganate Mohr, Stefan; Taschwer, Magdalena; Schmid, Martin G.; Chirality; vol. 24; nb. 6; (2012); p. 486 - 492 View in Reaxys 2.4 With (R)-epinephrine dehydrogenase, NADH in aq. phosphate buffer, T= 45 °C , pH= 6, Enzymatic reaction He, Shengbin; Wang, Zhenshou; Zou, Yang; Chen, Shaofang; Xu, Xiaoping; Process Biochemistry; vol. 49; nb. 7; (2014); p. 1107 - 1112 View in Reaxys

Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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2017-11-28 21:47:20


H N

H

OH

H

NH

O

H

Rx-ID: 29130431 View in Reaxys 3/6 Yield

Conditions & References Stage 1: With sodium dichromate, sulfuric acid in water, Time= 12.3333h, T= 15 - 20 °C Stage 2: With sodium hydroxide in water, toluene, T= 20 °C , pH= 10.5, Further stages Hitesh Kumar, Borkatte N.; Murugesan, Velayudham; Prakasam, Tangirala; Srinivasan, Pathangi S.; Ramana, Devalla V.; Tetrahedron Asymmetry; vol. 20; nb. 24; (2009); p. 2773 - 2779 View in Reaxys With potassium permanganate Mohr, Stefan; Taschwer, Magdalena; Schmid, Martin G.; Chirality; vol. 24; nb. 6; (2012); p. 486 - 492 View in Reaxys

O

H N

H

OH

HN

H

Rx-ID: 33584347 View in Reaxys 4/6 Yield

Conditions & References With potassium permanganate, acetic acid, Time= 0.5h, T= 20 - 60 °C Smoluch, Marek; Reszke, Edward; Ramsza, Andrzej; Labuz, Krzysztof; Silberring, Jerzy; Rapid Communications in Mass Spectrometry; vol. 26; nb. 13; (2012); p. 1577 - 1580 View in Reaxys

H N H HN

O

OH H

racemate

Rx-ID: 438154 View in Reaxys 5/6 Yield

Conditions & References With Catalyst M-Chromium oxide, sulfuric acid Patent; Merck; DE495534; Fortschr. Teerfarbenfabr. Verw. Industriezweige; vol. 16; p. 2467 View in Reaxys

H N H HN

OH

O

Cr2O3-H2SO4

H

racemate

Rx-ID: 7993925 View in Reaxys 6/6 Yield

Conditions & References Patent; Merck,E.; DE495534; Fortschr. Teerfarbenfabr. Verw. Industriezweige; vol. 16; p. 2467 View in Reaxys

Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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2017-11-28 21:47:20


Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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2017-11-28 21:47:20


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