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Citations (33)
References
1
Synthesize Find similar 24%
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Rx-ID: 21942163 Find similar reactions
in acetonitrile
Electrolysis;
Stalder, Romain; Roth, Gregory P.
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 11 p. 1119 - 1123 Title/Abstract Full Text View citing articles Show Details
Multi-step reaction with 2 steps 1: 22 percent / CrO3 / acetic acid / 0.17 h / 20 °C 2: 38 percent / CrO3 / acetic acid / 0.17 h / 20 °C View Scheme
Lafont; Cave; Menager; Miocque
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 1 p. 61 - 66 Title/Abstract Full Text View citing articles Show Details
2
Synthesize Find similar 5-Aethyl-5-phenyl-<2-14C>barbitursaeure;
Rx-ID: 5504415 Find similar reactions
Cacace; Montefinale
Ricerca Scientifica, 1958 , vol. 28, p. 1419,1421 Full Text View citing articles Show Details
Okui; Kuroiwa
Chemical and Pharmaceutical Bulletin, 1963 , vol. 11, p. 163,165 Full Text View citing articles Show Details
Brandstaetter-Kuhnert
Scientia Pharmaceutica, 1960 , vol. 28, p. 150 Chem.Abstr., 1960 , # 23197 Full Text View citing articles Show Details
Shimo; Wakamatsu
Kogyo Kagaku Zasshi, 1960 , vol. 63, p. 2150,2151 Chem.Abstr., vol. 58, # 2452 Full Text View citing articles Show Details
Spassov; Raikov
Zeitschrift fuer Chemie (Stuttgart, Germany), 1971 , vol. 11, p. 260 Full Text View citing articles Show Details
Neville
Analytical Chemistry, 1970 , vol. 42, p. 347,349 Full Text View citing articles Show Details
Kuhnert-Brandstätter; Bachleitner-Hofmann
Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft, 1971 , vol. 304, # 8 p. 580 - 590 Title/Abstract Full Text View citing articles Show Details
Stajer et al.
Archiv der Pharmazie (Weinheim, Germany), 1977 , vol. 310, p. 326,328,329 Full Text View citing articles Show Details
Vida; Hooker; Reinhard
Journal of Medicinal Chemistry, 1973 , vol. 16, p. 602 - 605 Title/Abstract Full Text View citing articles Show Details
Fuerst; Hendel
Patent: DD60038 , 1968 ; Chem.Abstr., 1969 , vol. 70, # 68415q Full Text Show Details
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
Patent: HU154226 , 1966 ; Chem.Abstr., 1968 , vol. 69, # 36159x Full Text Show Details
Mesley; Clements; Flaherty; Goodhead
The Journal of pharmacy and pharmacology, 1968 , vol. 20, # 5 p. 329 - 340 Title/Abstract Full Text View citing articles Show Details
Bojarski; Kahl
Roczniki Chemii, 1967 , vol. 41, # 2 p. 311 Full Text Show Details
Hide Experimental Procedure
Hyperion, Inc.
Patent: US6060598 A1, 2000 ; Title/Abstract Full Text Show Details
13.C:C. C. Preparation of Probe The phenobarbital probe was prepared as follows: 1.2 mg of 5-ethyl-5-(aminophenyl)barbituric acid (P-aminophenobarbital) was placed in a 3.0 ml reaction vial and dissolved with 200 μl DMF. In a separate vial the caged dicarboxy silicon phthalocyanine (1.0 mg) was dissolved in 200 μl DMF and then transferred to the reaction vial. To the reaction vial was added 2.4 mg HOBT, dissolved and mixed well. To make the final reaction mixture, 2.8 mg of EDAC was added and mixed thoroughly. The reaction mixture was stored overnight at about 4 to 8° C.
A
B
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3
Rx-ID: 24467069 Find similar reactions
Research Development Corp. of Japan; Stanley Electric Co., Ltd.
Patent: US5354563 A1, 1994 ;
Hide Experimental Procedure
Title/Abstract Full Text Show Details
3:EXAMPLE 3
Phenobarbital: m.p. 174°-178° C. (sedative, hypnotic, antiepileptic; crystalline powder) Phenobarbital Sodium:
4
Synthesize Find similar 38%
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With chromium(VI) oxide in acetic acid
T=20°C; 0.166667 h;
Rx-ID: 2228097 Find similar reactions
Lafont; Cave; Menager; Miocque
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 1 p. 61 - 66 Title/Abstract Full Text View citing articles Show Details
5
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Rx-ID: 748306 Find similar reactions
14%
With N(Et)4ClO4 in N,N-dimethyl-formamide
Ambient temperatureelectrolysis;
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Arai; Tamura; Kawai; Nakajima
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 11 p. 3117 - 3118 Title/Abstract Full Text View citing articles Show Details
With sodium ethanolate
Bayer and Co.
Patent: DE247952 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 11, p. 926 Full Text Show Details
6
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Rx-ID: 1795502 Find similar reactions
91%
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With pyridine in chloroform
T=40°C; 4 h;
Kopinski, Richard P.; Pinhey, John T.; Rowe, Bruce A.
Australian Journal of Chemistry, 1984 , vol. 37, # 6 p. 1245 - 1254 Title/Abstract Full Text Show Details
With pyridine in chloroform
T=40°C; Yield given;
Pinhey, John T.; Rowe, Bruce A.
Tetrahedron Letters, 1980 , vol. 21, p. 965 - 968 Title/Abstract Full Text View citing articles Show Details
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B
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7
Synthesize Find similar Rx-ID: 2098871 Find similar reactions
metabolism study in epileptic fowl;
8
Johnson; Davis
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 12 p. 1753 - 1757 Title/Abstract Full Text View citing articles Show Details
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Rx-ID: 2127434 Find similar reactions
64%
With hydrogenchloride; sodium nitrite in dichloromethane; water
T=45°C; 1.5 h;
Joergensen, K. A.; Ghattas, A.-B.A.G.; Lawesson, S.-O.
Tetrahedron, 1982 , vol. 38, # 9 p. 1163 - 1168 Title/Abstract Full Text View citing articles Show Details
10%
With tert-butylhypochlorite in tetrachloromethane; ethanol
T=40°C; 8 h;
El-Wassimy, M.T.M.; Jorgensen, K.A.; Lawesson, S.-O.
Tetrahedron, 1983 , vol. 39, # 10 p. 1729 - 1734 Title/Abstract Full Text View citing articles Show Details
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C
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9
Synthesize Find similar Rx-ID: 3498179 Find similar reactions
A: 85% B: 5% C: 4%
in ethanol
T=70°C; various pH, temp., Ea; KineticsRate constantProduct distribution;
Paluchowska, Maria; Ekiert, Leszek; Jochym, Krystyna; Bojarski, Jacek
Polish Journal of Chemistry, 1983 , vol. 57, # 7-9 p. 799 - 807 Title/Abstract Full Text Show Details
A: 85% B: 5% C: 4%
in sodium hydroxide
T=70°C; 8 h;
Paluchowska, Maria; Ekiert, Leszek; Jochym, Krystyna; Bojarski, Jacek
Polish Journal of Chemistry, 1983 , vol. 57, # 7-9 p. 799 - 807 Title/Abstract Full Text Show Details
A
B
C
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10
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Rx-ID: 3498180 Find similar reactions
A: 30% B: 40%
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Find similar
Paluchowska, Maria; Ekiert, Leszek; Jochym, Krystyna; Bojarski, Jacek
Polish Journal of Chemistry, 1983 , vol. 57, # 7-9 p. 799 - 807 Title/Abstract Full Text Show Details
T=70°C; 8 h; buffer pH 13;
11
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Rx-ID: 25269543 Find similar reactions
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With CaCl2; sodium hydrogencarbonate in methanol; water; N,N-dimethyl-formamide
Hide Experimental Procedure
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Syva Company
Patent: US3966744 A1, 1976 ; Title/Abstract Full Text Show Details
4.1.B:N-Carboxymethyl phenobarbitone
B. A solution of sodium phenobarbitone (8.8 g, 35 mmoles), and sodium chloroacetate (4.5 g, 38 mmoles) in methanol (250 ml) was mixed with a solution of CaCl2 (3 g) in methanol (50 ml). After addition of 5 ml DMF the mixture was refluxed for 36 hours. After removal of the solvent, the residue was treated with water (100 ml) and acidified with conc. HCl followed by extraction with chloroform. The organic layer was evaporated to dryness and the residue treated with 10percent NaHCO3 solution. Extraction with chloroform and evaporation of the organic layer yielded 3 g of unreacted phenobarbital. The bicarbonate layer was acidified with conc. HCl and extracted with chloroform.
12
Synthesize Find similar With sulfuric acid
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Rx-ID: 345111 Find similar reactions
Dvornik et al.
Arhiv za Kemiju, 1954 , vol. 26, p. 15,17 Full Text View citing articles Show Details
13
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With sulfuric acid
Rx-ID: 398954 Find similar reactions
Dvornik et al.
Arhiv za Kemiju, 1954 , vol. 26, p. 15,17 Full Text View citing articles Show Details
14
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Rx-ID: 22315546 Find similar reactions
Multi-step reaction with 2 steps 2: aqueous H2SO4
View Scheme
Dvornik et al.
Arhiv za Kemiju, 1954 , vol. 26, p. 15,17 Full Text View citing articles Show Details
Multi-step reaction with 2 steps 2: aqueous H2SO4
View Scheme
Dvornik et al.
Arhiv za Kemiju, 1954 , vol. 26, p. 15,17 Full Text View citing articles Show Details
15
Synthesize Find similar With hydrogenchloride
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Rx-ID: 330211 Find similar reactions
Chamberlain et al.
Journal of the American Chemical Society, 1935 , vol. 57, p. 352 Full Text View citing articles Show Details
16
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Multi-step reaction with 3 steps 1: diethyl ether 2: ethanol 3: aqueous HCl View Scheme
Rx-ID: 22312727 Find similar reactions
Chamberlain et al.
Journal of the American Chemical Society, 1935 , vol. 57, p. 352 Full Text View citing articles Show Details
17
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Multi-step reaction with 2 steps 1: ethanol 2: aqueous HCl View Scheme
Rx-ID: 22314752 Find similar reactions
Chamberlain et al.
Journal of the American Chemical Society, 1935 , vol. 57, p. 352 Full Text View citing articles Show Details
18
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Rx-ID: 5504417 Find similar reactions
Nelson; Cretcher
Journal of the American Chemical Society, 1928 , vol. 50, p. 2761 Full Text View citing articles Show Details
19
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Rx-ID: 747286 Find similar reactions
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Rising; Stieglitz
Journal of the American Chemical Society, 1918 , vol. 40, p. 728 Full Text Show Details
20
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Rx-ID: 747973 Find similar reactions
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With sodium methylate
T=105 - 108°C; im Rohr;
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Rising; Stieglitz
Journal of the American Chemical Society, 1918 , vol. 40, p. 728 Full Text Show Details
21
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Rx-ID: 262076 Find similar reactions
With sodium hydroxide
T=100°C; im Rohr;
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Bayer and Co.
Patent: DE247952 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 11, p. 926 Full Text Show Details
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22
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With hydrogenchloride
Rx-ID: 375833 Find similar reactions
Bayer and Co.
Patent: DE249722 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 11, p. 929 Full Text Show Details
23
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Rx-ID: 748305 Find similar reactions
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Bayer and Co
Patent: DE247952 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 11, p. 926 Full Text Show Details
24
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Rx-ID: 5504416 Find similar reactions
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Bayer and Co.
Patent: DE249722 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 11, p. 928 Full Text Show Details
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25
Synthesize Find similar Multi-step reaction with 2 steps 1: sodium ethylate / 100 °C / im Rohr 2: NaOH-solution / 100 °C / im Rohr View Scheme
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Rx-ID: 22314686 Find similar reactions
Bayer and Co.
Patent: DE247952 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 11, p. 926 Full Text Show Details