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199
Synthesize Find similar Multi-step reaction with 6 steps 1.1: potassium carbonate / 6 h / 100 °C 2.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 3.1: pyridine / 6 h / 20 °C 4.1: sodium methylate / methanol / 0.5 h / 0 °C 5.1: lithium perchlorate / acetonitrile / 48 h / Reflux 6.1: acetic acid / ethanol / 1 h / 0 °C 6.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943704 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
200
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Hide Experimental Procedure
Rx-ID: 23883839 Find similar reactions
Merce-Vidal, Ramon; Andaluz-Mataro, Blas; Frigola-Constansa, Jordi
Patent: US2003/191124 A1, 2003 ; Title/Abstract Full Text Show Details
Compounds object of the present invention that correspond to the above formula can be selected from among ... [15] N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]-4-phenylbenzenesulphonamide. [16] N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]quinoline-8-sulphonamide. [17] N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]naphthalene-2-sulphonamide. [18] N-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]naphthalene-1-sulphonamide [19] N-[3-(4-methylpiperazin-1-yl)methyl-1H-indol-5-yl]-5-chloro-3-methylbenzo[b]thiophene-2-sulphonamide.
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Merce-Vidal, Ramon; Andaluz-Mataro, Blas; Frigola-Constansa, Jordi
Patent: US2003/191124 A1, 2003 ; Title/Abstract Full Text Show Details
, selected from among the following group: ... [15] N-[3-(1-methylpiperdin-4-yl)-1H-indol-5-yl]-4-phenylbenzenesulphonamide. [16] N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]quinoline-8-sulphonamide. [17] N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]naphthalene-2-sulphonamide. [18] N-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]naphthalene-1-sulphonamide. [19] N-[3-(4-methylpiperazin-1-yl)methyl-1H-indol-5-yl]-5-chloro-3-methylbenzo[b]thiophene-2-sulphonamide.
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Laboratorios del Dr. Esteve S.A.
Patent: EP2018861 A1, 2009 ; Title/Abstract Full Text Show Details
It is further preferred if the compound binding to the 5HT6-receptor being used according to the invention is selected from the following group of sulfonamide compounds according to formula lba consisting of: ... [15] N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]-4-phenylbenzenesulphonamide. [16] N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]quinoline-8-sulphonamide. [17] N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]naphthalene-2-sulphonamide. [18] N-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]naphthalene-1-sulphonamide. [19] N-[3-(4-methylpiperazin-1-yl)methyl-1H-indol-5-yl]-5-chloro-3-methylbenzo[b]thiophene-2-sulphonamide. Hide Details
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Laboratorios del Dr. Esteve S.A.
Patent: EP2018861 A1, 2009 ; Title/Abstract Full Text Show Details
Use according to claim 8, wherein the compound binding to the 5HT6-receptor is selected from the following group of sulfonamide compounds according to formula Iba consisting of: ... [15] N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]-4-phenylbenzenesulphonamide. [16] N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]quinoline-8-sulphonamide. [17] N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]naphthalene-2-sulphonamide. [18] N-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]naphthalene-1-sulphonamide.
[19] N-[3-(4-methylpiperazin-1-yl)methyl-1H-indol-5-yl]-5-chloro-3-methylbenzo[b]thiophene-2-sulphonamide.
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Laboratorios del Dr. Esteve S.A.
Patent: EP2020230 A1, 2009 ; Title/Abstract Full Text Show Details
It is a further preferred embodiment of the combination of active substances according to the invention if the compound/s binding to the 5HT6-receptor according to formula (Iba) is/are selected from the following group of sulfonamide compounds consisting of: ... [15] N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]-4-phenylbenzenesulphonamide. [16] N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]quinoline-8-sulphonamide. [17] N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]naphthalene-2-sulphonamide. [18] N-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]naphthalene-1-sulphonamide. [19] N-[3-(4-methylpiperazin-1-yl)methyl-1H-indol-5-yl]-5-chloro-3-methylbenzo[b]thiophene-2-sulphonamide.
Hide Experimental Procedure
Laboratorios del Dr. Esteve S.A.
Patent: EP2020230 A1, 2009 ; Title/Abstract Full Text Show Details
A combination of active substances according to claim 14, wherein the compound/s binding to the 5HT6-receptor is/are selected from the following group of sulfonamide compounds according to formula (Iba) consisting of: ... [15] N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]-4-phenylbenzenesulphonamide. [16] N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]quinoline-8-sulphonamide. [17] N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]naphthalene-2-sulphonamide. [18] N-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]naphthalene-1-sulphonamide. [19] N-[3-(4-methylpiperazin-1-yl)methyl-1H-indol-5-yl]-5-chloro-3-methylbenzo[b]thiophene-2-sulphonamide.
201
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Rx-ID: 32943569 Find similar reactions
202
Stage #1: formaldehyd; (2R,3R)-2(2,4-difluorophenyl)-3-(piperazin-1yl)-1-(1H-1,2,4-triazol-1-yl)butan-2ol With acetic acid in ethanol
T=0°C; 1 h; Stage #2: 1H-indole-5-carbonitrile in ethanol
T=0 - 40°C; 12 h;
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Synthesize Find similar
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
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Synthesize Find similar
Multi-step reaction with 7 steps 1.1: dichloromethane / 70 °C 2.1: potassium carbonate / 6 h / 100 °C 3.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 4.1: pyridine / 6 h / 20 °C 5.1: sodium methylate / methanol / 0.5 h / 0 °C 6.1: lithium perchlorate / acetonitrile / 48 h / Reflux 7.1: acetic acid / ethanol / 1 h / 0 °C 7.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943590 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
203
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Multi-step reaction with 2 steps 1.1: lithium perchlorate / acetonitrile / 48 h / Reflux 2.1: acetic acid / ethanol / 1 h / 0 °C 2.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943612 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
204
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Multi-step reaction with 4 steps 1.1: pyridine / 6 h / 20 °C 2.1: sodium methylate / methanol / 0.5 h / 0 °C 3.1: lithium perchlorate / acetonitrile / 48 h / Reflux 4.1: acetic acid / ethanol / 1 h / 0 °C 4.2: 12 h / 0 - 40 °C
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Rx-ID: 32943636 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
View Scheme
205
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Multi-step reaction with 3 steps 1.1: sodium methylate / methanol / 0.5 h / 0 °C 2.1: lithium perchlorate / acetonitrile / 48 h / Reflux 3.1: acetic acid / ethanol / 1 h / 0 °C 3.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943660 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
206
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207
Multi-step reaction with 5 steps 1.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 2.1: pyridine / 6 h / 20 °C 3.1: sodium methylate / methanol / 0.5 h / 0 °C 4.1: lithium perchlorate / acetonitrile / 48 h / Reflux 5.1: acetic acid / ethanol / 1 h / 0 °C 5.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943686 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
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Multi-step reaction with 6 steps 1.1: potassium carbonate / 6 h / 100 °C 2.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 3.1: pyridine / 6 h / 20 °C 4.1: sodium methylate / methanol / 0.5 h / 0 °C 5.1: lithium perchlorate / acetonitrile / 48 h / Reflux 6.1: acetic acid / ethanol / 1 h / 0 °C 6.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943711 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
208
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Rx-ID: 32943568 Find similar reactions
209
Stage #1: formaldehyd; (2R,3R)-2(2,4-difluorophenyl)-3-(piperazin-1yl)-1-(1H-1,2,4-triazol-1-yl)butan-2ol With acetic acid in ethanol
T=0°C; 1 h; Stage #2: 5-Methoxy-1H-indole in ethanol
T=0 - 40°C; 12 h;
Synthesize Find similar
Synthesize Find similar
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
Synthesize Find similar
Synthesize Find similar
Multi-step reaction with 7 steps 1.1: dichloromethane / 70 °C 2.1: potassium carbonate / 6 h / 100 °C 3.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 4.1: pyridine / 6 h / 20 °C 5.1: sodium methylate / methanol / 0.5 h / 0 °C 6.1: lithium perchlorate / acetonitrile / 48 h / Reflux 7.1: acetic acid / ethanol / 1 h / 0 °C 7.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943588 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
210
Synthesize Find similar
Multi-step reaction with 2 steps 1.1: lithium perchlorate / acetonitrile / 48 h / Reflux 2.1: acetic acid / ethanol / 1 h / 0 °C 2.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943610 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
211
Synthesize Find similar
Multi-step reaction with 4 steps 1.1: pyridine / 6 h / 20 °C 2.1: sodium methylate / methanol / 0.5 h / 0 °C 3.1: lithium perchlorate / acetonitrile / 48 h / Reflux 4.1: acetic acid / ethanol / 1 h / 0 °C 4.2: 12 h / 0 - 40 °C
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Rx-ID: 32943634 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
View Scheme
212
Synthesize Find similar
Multi-step reaction with 3 steps 1.1: sodium methylate / methanol / 0.5 h / 0 °C 2.1: lithium perchlorate / acetonitrile / 48 h / Reflux 3.1: acetic acid / ethanol / 1 h / 0 °C 3.2: 12 h / 0 - 40 °C View Scheme
Synthesize Find similar
Rx-ID: 32943658 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
213
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214
Multi-step reaction with 5 steps 1.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 2.1: pyridine / 6 h / 20 °C 3.1: sodium methylate / methanol / 0.5 h / 0 °C 4.1: lithium perchlorate / acetonitrile / 48 h / Reflux 5.1: acetic acid / ethanol / 1 h / 0 °C 5.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943684 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
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Multi-step reaction with 6 steps 1.1: potassium carbonate / 6 h / 100 °C 2.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 3.1: pyridine / 6 h / 20 °C 4.1: sodium methylate / methanol / 0.5 h / 0 °C 5.1: lithium perchlorate / acetonitrile / 48 h / Reflux 6.1: acetic acid / ethanol / 1 h / 0 °C 6.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943709 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
215
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Rx-ID: 23023108 Find similar reactions
XENOVA LIMITED
Patent: WO2004/65389 A1, 2004 ; Location in patent: Page 51 ;
Title/Abstract Full Text Show Details
216
Rx-ID: 32943575
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Synthesize Find similar
Synthesize Find similar
Synthesize Find similar
Find similar reactions
Stage #1: formaldehyd; (2R,3R)-2(2,4-difluorophenyl)-3-(piperazin-1yl)-1-(1H-1,2,4-triazol-1-yl)butan-2ol With acetic acid in ethanol
T=0°C; 1 h; Stage #2: 5-chloro-1H-indole in ethanol
T=0 - 40°C; 12 h;
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
217
Synthesize Find similar
Multi-step reaction with 7 steps 1.1: dichloromethane / 70 °C 2.1: potassium carbonate / 6 h / 100 °C 3.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 4.1: pyridine / 6 h / 20 °C 5.1: sodium methylate / methanol / 0.5 h / 0 °C 6.1: lithium perchlorate / acetonitrile / 48 h / Reflux 7.1: acetic acid / ethanol / 1 h / 0 °C 7.2: 12 h / 0 - 40 °C View Scheme
Synthesize Find similar
Rx-ID: 32943584 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
218
Synthesize Find similar
Multi-step reaction with 2 steps 1.1: lithium perchlorate / acetonitrile / 48 h / Reflux 2.1: acetic acid / ethanol / 1 h / 0 °C 2.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943606 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
219
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Multi-step reaction with 4 steps 1.1: pyridine / 6 h / 20 °C 2.1: sodium methylate / methanol / 0.5 h / 0 °C 3.1: lithium perchlorate / acetonitrile / 48 h / Reflux 4.1: acetic acid / ethanol / 1 h / 0 °C 4.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943630 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
220
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Multi-step reaction with 3 steps 1.1: sodium methylate / methanol / 0.5 h / 0 °C 2.1: lithium perchlorate / acetonitrile / 48 h / Reflux 3.1: acetic acid / ethanol / 1 h / 0 °C 3.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943654 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
221
Synthesize Find similar
Synthesize Find similar
Rx-ID: 32943680 Find similar reactions
Multi-step reaction with 5 steps 1.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 2.1: pyridine / 6 h / 20 °C 3.1: sodium methylate / methanol / 0.5 h / 0 °C 4.1: lithium perchlorate / acetonitrile / 48 h / Reflux 5.1: acetic acid / ethanol / 1 h / 0 °C 5.2: 12 h / 0 - 40 °C View Scheme
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
222
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Multi-step reaction with 6 steps 1.1: potassium carbonate / 6 h / 100 °C 2.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 3.1: pyridine / 6 h / 20 °C 4.1: sodium methylate / methanol / 0.5 h / 0 °C 5.1: lithium perchlorate / acetonitrile / 48 h / Reflux 6.1: acetic acid / ethanol / 1 h / 0 °C 6.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943705 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
223
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Rx-ID: 32943578 Find similar reactions
Stage #1: formaldehyd; (2R,3R)-2(2,4-difluorophenyl)-3-(piperazin-1yl)-1-(1H-1,2,4-triazol-1-yl)butan-2ol With acetic acid in ethanol
T=0°C; 1 h; Stage #2: 5-azido-1H-indole in ethanol
T=0 - 40°C; 12 h;
Synthesize Find similar
Synthesize Find similar
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
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224
Synthesize Find similar
Multi-step reaction with 7 steps 1.1: dichloromethane / 70 °C 2.1: potassium carbonate / 6 h / 100 °C 3.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 4.1: pyridine / 6 h / 20 °C 5.1: sodium methylate / methanol / 0.5 h / 0 °C 6.1: lithium perchlorate / acetonitrile / 48 h / Reflux 7.1: acetic acid / ethanol / 1 h / 0 °C 7.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943589 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
225
Synthesize Find similar
226
Multi-step reaction with 2 steps 1.1: lithium perchlorate / acetonitrile / 48 h / Reflux 2.1: acetic acid / ethanol / 1 h / 0 °C 2.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943611 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
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Multi-step reaction with 4 steps 1.1: pyridine / 6 h / 20 °C 2.1: sodium methylate / methanol / 0.5 h / 0 °C 3.1: lithium perchlorate / acetonitrile / 48 h / Reflux 4.1: acetic acid / ethanol / 1 h / 0 °C 4.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943635 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
227
Synthesize Find similar
Multi-step reaction with 3 steps 1.1: sodium methylate / methanol / 0.5 h / 0 °C 2.1: lithium perchlorate / acetonitrile / 48 h / Reflux 3.1: acetic acid / ethanol / 1 h / 0 °C 3.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943659 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
228
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Synthesize Find similar
Rx-ID: 32943685 Find similar reactions
Multi-step reaction with 5 steps 1.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 2.1: pyridine / 6 h / 20 °C 3.1: sodium methylate / methanol / 0.5 h / 0 °C 4.1: lithium perchlorate / acetonitrile / 48 h / Reflux 5.1: acetic acid / ethanol / 1 h / 0 °C 5.2: 12 h / 0 - 40 °C View Scheme
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
229
Synthesize Find similar
Multi-step reaction with 6 steps 1.1: potassium carbonate / 6 h / 100 °C 2.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 3.1: pyridine / 6 h / 20 °C 4.1: sodium methylate / methanol / 0.5 h / 0 °C 5.1: lithium perchlorate / acetonitrile / 48 h / Reflux 6.1: acetic acid / ethanol / 1 h / 0 °C 6.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943710 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
230
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Rx-ID: 29771462 Find similar reactions
MERCK SHARP andamp;; DOHME CORP.; STUMP, Craig, A.; QUIGLEY, Amy, G.; THEBERGE, Cory, R.; WOOD, Michael, R.
Patent: WO2010/107605 A1, 2010 ; Location in patent: Page/Page column 95; 97 ; Title/Abstract Full Text Show Details
231
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Rx-ID: 32943573 Find similar reactions
Stage #1: formaldehyd; (2R,3R)-2(2,4-difluorophenyl)-3-(piperazin-1yl)-1-(1H-1,2,4-triazol-1-yl)butan-2ol With acetic acid in ethanol
T=0°C; 1 h; Stage #2: 1H-indole-5carbaldehyde oxime in ethanol
T=0 - 40°C; 12 h;
Synthesize Find similar
Synthesize Find similar
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
232
Synthesize Find similar
233
Multi-step reaction with 7 steps 1.1: dichloromethane / 70 °C 2.1: potassium carbonate / 6 h / 100 °C 3.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 4.1: pyridine / 6 h / 20 °C 5.1: sodium methylate / methanol / 0.5 h / 0 °C 6.1: lithium perchlorate / acetonitrile / 48 h / Reflux 7.1: acetic acid / ethanol / 1 h / 0 °C 7.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943591 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
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Synthesize Find similar
Multi-step reaction with 2 steps 1.1: lithium perchlorate / acetonitrile / 48 h / Reflux 2.1: acetic acid / ethanol / 1 h / 0 °C 2.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943613 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
234
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Multi-step reaction with 4 steps 1.1: pyridine / 6 h / 20 °C 2.1: sodium methylate / methanol / 0.5 h / 0 °C 3.1: lithium perchlorate / acetonitrile / 48 h / Reflux 4.1: acetic acid / ethanol / 1 h / 0 °C 4.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943637 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
235
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Synthesize Find similar
Rx-ID: 32943661 Find similar reactions
Multi-step reaction with 3 steps 1.1: sodium methylate / methanol / 0.5 h / 0 °C 2.1: lithium perchlorate / acetonitrile / 48 h / Reflux 3.1: acetic acid / ethanol / 1 h / 0 °C 3.2: 12 h / 0 - 40 °C View Scheme
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
236
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Multi-step reaction with 5 steps 1.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 2.1: pyridine / 6 h / 20 °C 3.1: sodium methylate / methanol / 0.5 h / 0 °C 4.1: lithium perchlorate / acetonitrile / 48 h / Reflux 5.1: acetic acid / ethanol / 1 h / 0 °C 5.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943687 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
237
Synthesize Find similar
Multi-step reaction with 6 steps 1.1: potassium carbonate / 6 h / 100 °C 2.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 3.1: pyridine / 6 h / 20 °C 4.1: sodium methylate / methanol / 0.5 h / 0 °C 5.1: lithium perchlorate / acetonitrile / 48 h / Reflux 6.1: acetic acid / ethanol / 1 h / 0 °C 6.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943712 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
238
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Rx-ID: 32943576 Find similar reactions
Stage #1: formaldehyd; (2R,3R)-2(2,4-difluorophenyl)-3-(piperazin-1yl)-1-(1H-1,2,4-triazol-1-yl)butan-2ol With acetic acid in ethanol
T=0°C; 1 h; Stage #2: 5-Nitro-1H-indole in ethanol
T=0 - 40°C; 12 h;
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Synthesize Find similar
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
239
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240
Multi-step reaction with 7 steps 1.1: dichloromethane / 70 °C 2.1: potassium carbonate / 6 h / 100 °C 3.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 4.1: pyridine / 6 h / 20 °C 5.1: sodium methylate / methanol / 0.5 h / 0 °C 6.1: lithium perchlorate / acetonitrile / 48 h / Reflux 7.1: acetic acid / ethanol / 1 h / 0 °C 7.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943587 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
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Synthesize Find similar
Multi-step reaction with 2 steps 1.1: lithium perchlorate / acetonitrile / 48 h / Reflux 2.1: acetic acid / ethanol / 1 h / 0 °C 2.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943609 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
241
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Multi-step reaction with 4 steps 1.1: pyridine / 6 h / 20 °C 2.1: sodium methylate / methanol / 0.5 h / 0 °C 3.1: lithium perchlorate / acetonitrile / 48 h / Reflux 4.1: acetic acid / ethanol / 1 h / 0 °C 4.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943633 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
242
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Synthesize Find similar
Rx-ID: 32943657 Find similar reactions
Multi-step reaction with 3 steps 1.1: sodium methylate / methanol / 0.5 h / 0 °C 2.1: lithium perchlorate / acetonitrile / 48 h / Reflux 3.1: acetic acid / ethanol / 1 h / 0 °C 3.2: 12 h / 0 - 40 °C View Scheme
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
243
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Multi-step reaction with 5 steps 1.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 2.1: pyridine / 6 h / 20 °C 3.1: sodium methylate / methanol / 0.5 h / 0 °C 4.1: lithium perchlorate / acetonitrile / 48 h / Reflux 5.1: acetic acid / ethanol / 1 h / 0 °C 5.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943683 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
244
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Multi-step reaction with 6 steps 1.1: potassium carbonate / 6 h / 100 °C 2.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 3.1: pyridine / 6 h / 20 °C 4.1: sodium methylate / methanol / 0.5 h / 0 °C 5.1: lithium perchlorate / acetonitrile / 48 h / Reflux 6.1: acetic acid / ethanol / 1 h / 0 °C 6.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943708 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
245
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Multi-step reaction with 3 steps 1: acetic acid / 35 °C 2: palladium on activated carbon; hydrogen / ethanol / 6 h / 20 °C 3: methanol / Reflux View Scheme
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Rx-ID: 46330279 Find similar reactions
Qin, Mingze; Tian, Ye; Sun, Xiaoqing; Yu, Simiao; Xia, Juanjuan; Gong, Ping; Zhang, Haotian; Zhao, Yanfang
European Journal of Medicinal Chemistry, 2017 , vol. 139, p. 492 - 502 Title/Abstract Full Text View citing articles Show Details
246
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Multi-step reaction with 3 steps 1: acetic acid / 35 °C 2: palladium on activated carbon; hydrogen / ethanol / 6 h / 20 °C 3: methanol / Reflux View Scheme
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Rx-ID: 46330358 Find similar reactions
Qin, Mingze; Tian, Ye; Sun, Xiaoqing; Yu, Simiao; Xia, Juanjuan; Gong, Ping; Zhang, Haotian; Zhao, Yanfang
European Journal of Medicinal Chemistry, 2017 , vol. 139, p. 492 - 502 Title/Abstract Full Text View citing articles Show Details
247
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Multi-step reaction with 2 steps 1: palladium on activated carbon; hydrogen / ethanol / 6 h / 20 °C 2: methanol / Reflux
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Rx-ID: 46330381 Find similar reactions
Qin, Mingze; Tian, Ye; Sun, Xiaoqing; Yu, Simiao; Xia, Juanjuan; Gong, Ping; Zhang, Haotian; Zhao, Yanfang
European Journal of Medicinal Chemistry, 2017 , vol. 139, p. 492 - 502 Title/Abstract Full Text View citing articles Show Details
View Scheme
248
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Rx-ID: 46330393 Find similar reactions
50%
in methanol
Reflux; Hide Experimental Procedure
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Synthesize Find similar
Qin, Mingze; Tian, Ye; Sun, Xiaoqing; Yu, Simiao; Xia, Juanjuan; Gong, Ping; Zhang, Haotian; Zhao, Yanfang
European Journal of Medicinal Chemistry, 2017 , vol. 139, p. 492 - 502 Title/Abstract Full Text View citing articles Show Details
4.1.12. General procedure for preparation of compounds A1-A17
General procedure: A mixture of intermediate (3a, 3b, 6a, 6b, 10a, 10b, 11a-d, and14a-g, 1.5 mmol) and methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate (1.5 mmol) in methanol (10 mL) wasstirred under reflux for 5-10 h. When TLC showed the completionof the reaction, the solution was cooled to room temperature. Theprecipitate was filtered off to give a crude product, which wasrecrystallized from methanol to provide the target compounds.
249
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Rx-ID: 23341952 Find similar reactions
SUGEN, INC.
Patent: WO2004/76412 A2, 2004 ; Location in patent: Page 101; 140 ;
Title/Abstract Full Text Show Details
250
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Rx-ID: 23341954 Find similar reactions
SUGEN, INC.
Patent: WO2004/76412 A2, 2004 ; Location in patent: Page 101; 140 ;
Title/Abstract Full Text Show Details
251
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Rx-ID: 23342495 Find similar reactions
SUGEN, INC.
Patent: WO2004/76412 A2, 2004 ; Location in patent: Page 117; 217 ;
Title/Abstract Full Text Show Details
252
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Rx-ID: 32943562 Find similar reactions
253
Stage #1: formaldehyd; (2R,3R)-2(2,4-difluorophenyl)-3-(piperazin-1yl)-1-(1H-1,2,4-triazol-1-yl)butan-2ol With acetic acid in ethanol
T=0°C; 1 h; Stage #2: 5-Bromo-1H-indole in ethanol
T=0 - 40°C; 12 h;
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Synthesize Find similar
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
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Synthesize Find similar
Multi-step reaction with 7 steps 1.1: dichloromethane / 70 °C 2.1: potassium carbonate / 6 h / 100 °C 3.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 4.1: pyridine / 6 h / 20 °C 5.1: sodium methylate / methanol / 0.5 h / 0 °C 6.1: lithium perchlorate / acetonitrile / 48 h / Reflux 7.1: acetic acid / ethanol / 1 h / 0 °C 7.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943585 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
254
Synthesize Find similar
Multi-step reaction with 2 steps 1.1: lithium perchlorate / acetonitrile / 48 h / Reflux 2.1: acetic acid / ethanol / 1 h / 0 °C 2.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943607 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
255
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Multi-step reaction with 4 steps 1.1: pyridine / 6 h / 20 °C 2.1: sodium methylate / methanol / 0.5 h / 0 °C 3.1: lithium perchlorate / acetonitrile / 48 h / Reflux 4.1: acetic acid / ethanol / 1 h / 0 °C 4.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943631 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
256
Synthesize Find similar
Multi-step reaction with 3 steps 1.1: sodium methylate / methanol / 0.5 h / 0 °C 2.1: lithium perchlorate / acetonitrile / 48 h / Reflux 3.1: acetic acid / ethanol / 1 h / 0 °C 3.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943655 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
257
Synthesize Find similar
258
Multi-step reaction with 5 steps 1.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 2.1: pyridine / 6 h / 20 °C 3.1: sodium methylate / methanol / 0.5 h / 0 °C 4.1: lithium perchlorate / acetonitrile / 48 h / Reflux 5.1: acetic acid / ethanol / 1 h / 0 °C 5.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943681 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
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Multi-step reaction with 6 steps 1.1: potassium carbonate / 6 h / 100 °C 2.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C 3.1: pyridine / 6 h / 20 °C 4.1: sodium methylate / methanol / 0.5 h / 0 °C 5.1: lithium perchlorate / acetonitrile / 48 h / Reflux 6.1: acetic acid / ethanol / 1 h / 0 °C 6.2: 12 h / 0 - 40 °C View Scheme
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Rx-ID: 32943706 Find similar reactions
Na, Young Min
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 11 p. 3467 - 3470 Title/Abstract Full Text View citing articles Show Details
259
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With methanol; sodium cyanoborohydride
T=20°C; 40 h; Hide Experimental Procedure
Rx-ID: 45192905 Find similar reactions
EXONATE LIMITED; BATES, David; MORRIS, Jonathan; TOOP, Hamish; BATSON, Jennifer
Patent: WO2017/64512 A1, 2017 ; Location in patent: Page/Page column 34; 55 ; Title/Abstract Full Text Show Details
General Procedure for the Syntheses of Compound 4
General procedure: Piperazine 3 (1 equiv.) and sodium cyanoborohydride (2 equiv.) were added successively as solids to a 0.1M solution of the R3 aldehyde (R3 as defined elsewhere) (1 equiv.) in methanol. The solution was allowed to stir at room temperature for 40 h. The solvent was removed under reduced pressure. The residue was diluted with saturated aqueous sodium bicarbonate solution and extracted with dichloromethane (x3). The organic extracts were combined and washed with brine, then dried (Na2SO4). The solvent was removed under reduced pressure. The crude product was purified by flash chromatography on deactivated silica gel, eluting with 2 - 5 percent methanol/ethyl acetate, to afford the product.
260
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Rx-ID: 34159609 Find similar reactions
OTSUKA PHARMACEUTICAL CO., LTD.; KAWANO, Yoshikazu; HARAGUCHI, Yoshikazu; SASAKI, Hirofumi; UEMATSU, Yukitaka; TSUBOUCHI, Hidetsugu; YATA, Hiromi; SHIMIZU, Hiroshi; KOHASHI, Kazuho; ITOTANI, Motohiro; TAI, Kuninori; TAKEMURA, Isao; HAYASHI, Mikayo; HASHIZUME, Hiroyuki; MATSUBA, Miki; NAKAMURA, Izuru; CHEN, Xiuhao; MATSUMOTO, Makoto
Patent: WO2012/141338 A1, 2012 ; Location in patent: Page/Page column 330; 346 ; Title/Abstract Full Text Show Details
261
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Rx-ID: 16467 Find similar reactions
With nitrogen; toluene
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Synthesize Find similar
Koo et al.
Journal of Organic Chemistry, 1959 , vol. 24, p. 179,183 Full Text View citing articles Show Details
262
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Rx-ID: 39008196 Find similar reactions
47%
With copper(l) iodide; N-ethylN,N-diisopropylamine in acetonitrile
T=20°C; Hide Experimental Procedure
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Synthesize Find similar
Hamann, Anton R.; De Kock, Carmen; Smith, Peter J.; Van Otterlo, Willem A.L.; Blackie, Margaret A.L.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 23 p. 5466 - 5469 Title/Abstract Full Text View citing articles Show Details
General procedure for the click reactions of 4-azido-2,8-bis(trifluoromethyl)quinoline with thecorresponding acetylenes
General procedure: 4-Azido-2,8-bis(trifluoromethyl)quinoline 8 (1.1 eq.) and the corresponding acetylene (1.0 eq.) were dissolved in CH3CN (1 mL). DIPEA (1.2 eq.) and CuI (0.25 eq.) were then added in that respective order. The solution was stirred overnight at rt and then concentrated. The mixture was diluted with DCM (20 mL) and washed with saturated NH4Cl solution (3 × 15 mL). The organic layer was dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. Purification was done using the appropriate solvent system to offer the corresponding product as a solid.
263
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Synthesize Find similar
Rx-ID: 39008219 Find similar reactions
Multi-step reaction with 4 steps 1: polyphosphoric acid / 3 h / 120 °C / |Inert atmosphere 2: trichlorophosphate / 5 h / 80 °C / |Inert atmosphere; |Reflux 3: sodium azide / N,N-dimethylformamide / 3 h / 55 °C / |Reflux; |Inert atmosphere 4: N-ethyl-N,N-diisopropylamine; copper(l) iodide / acetonitrile / 20 °C View Scheme
Hamann, Anton R.; De Kock, Carmen; Smith, Peter J.; Van Otterlo, Willem A.L.; Blackie, Margaret A.L.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 23 p. 5466 - 5469 Title/Abstract Full Text View citing articles Show Details
264
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Multi-step reaction with 3 steps 1: trichlorophosphate / 5 h / 80 °C / |Inert atmosphere; |Reflux 2: sodium azide / N,N-dimethylformamide / 3 h / 55 °C / |Reflux; |Inert atmosphere 3: N-ethyl-N,N-diisopropylamine; copper(l) iodide / acetonitrile / 20 °C View Scheme
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Rx-ID: 39008290 Find similar reactions
Hamann, Anton R.; De Kock, Carmen; Smith, Peter J.; Van Otterlo, Willem A.L.; Blackie, Margaret A.L.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 23 p. 5466 - 5469 Title/Abstract Full Text View citing articles Show Details
265
Synthesize Find similar
Multi-step reaction with 2 steps 1: sodium azide / N,N-dimethylformamide / 3 h / 55 °C / |Reflux; |Inert atmosphere 2: N-ethyl-N,N-diisopropylamine; copper(l) iodide / acetonitrile / 20 °C View Scheme
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Rx-ID: 39008302 Find similar reactions
Hamann, Anton R.; De Kock, Carmen; Smith, Peter J.; Van Otterlo, Willem A.L.; Blackie, Margaret A.L.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 23 p. 5466 - 5469 Title/Abstract Full Text View citing articles Show Details
266
Synthesize Find similar
Multi-step reaction with 2 steps 1: acetic acid / isopropyl alcohol; ethanol / 20 °C 2: N-ethyl-N,N-diisopropylamine; copper(l) iodide / acetonitrile / 20 °C View Scheme
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Hamann, Anton R.; De Kock, Carmen; Smith, Peter J.; Van Otterlo, Willem A.L.; Blackie, Margaret A.L.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 23 p. 5466 - 5469 Title/Abstract Full Text View citing articles Show Details
267
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Rx-ID: 23803970 Find similar reactions
JANSSEN PHARMACEUTICA N.V.
Patent: WO2006/67139 A1, 2006 ; Location in patent: Page/Page column 95 ;
Title/Abstract Full Text Show Details
268
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Hide Experimental Procedure
Rx-ID: 39008314 Find similar reactions
Rx-ID: 24167113 Find similar reactions
SmithKline Beecham Corporation
Patent: US6552022 B1, 2003 ; Title/Abstract Full Text Show Details
A compound according to claim 1selected from the group consisting of: ... 4'-Trifluoromethyl-biphenyl-2-carboxylic acid [4-(4-(1-methyl-1H-pyrrol-2-ylmethyl)-piperazin-1-yl)-phenyl]-amide; 4'-Trifluoromethyl-biphenyl-2-carboxylic acid [4-(4-thiophen-2-ylmethyl-piperazin-1-yl)-phenyl]-amide; 4'-Trifluoromethyl-biphenyl-2-carboxylic acid {4-[4-(1H-pyrazole-3-ylmethyl)-piperazine-1-yl]-phenyl}-amide; 4'-Trifluoromethyl-biphenyl-2-carboxylic acid [4-(4-thiophen-3-ylmethyl-piperazin-1-yl)-phenyl]-amide; 4'-Trifluoromethyl-biphenyl-2-carboxylic acid {4-[4-(5-fluoro-1H-indol-3-ylmethyl)-piperazin-1-yl]-phenyl}-amide; 4'-Isopropyl-6-methoxy'-biphenyl-2-carboxylic acid (4-(4-(3-(3-methyl-[1,2,4]oxadiazol-5-yl)-benzyl)-piperazine-1-yl)-phenyl)-amide; 4'-Trifluoromethyl-biphenyl-2-carboxylic acid (4-{4-[3-(5-trifluoromethyl-1,2,4]oxadiazol-3-yl)-benzyl]-piperazin-1-yl}-phenyl)-amide;
269
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Rx-ID: 23627746 Find similar reactions
OTSUKA PHARMACEUTICAL CO., LTD.
Patent: WO2005/105778 A2, 2005 ; Location in patent: Page/Page column 178 ;
Title/Abstract Full Text Show Details
270
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Multi-step reaction with 3 steps 1.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane / 0.08 h / 0 °C / |Inert atmosphere 1.2: 1.5 h / 20 °C / |Inert atmosphere 2.1: sodium tris(acetoxy)borohydride / dichloromethane / 48 h / 20 °C / |Inert atmosphere 3.1: dichloromethane / 2 h / 0 - 20 °C / |Inert atmosphere View Scheme
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Rx-ID: 41493279 Find similar reactions
Das, Banibrata; Vedachalam, Seenuvasan; Luo, Dan; Antonio, Tamara; Reith, Maarten E. A.; Dutta, Aloke K.
Journal of Medicinal Chemistry, 2015 , vol. 58, # 23 p. 9179 - 9195 Title/Abstract Full Text View citing articles Show Details
271
Synthesize Find similar
Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride / dichloromethane / 48 h / 20 °C / |Inert atmosphere 2: dichloromethane / 2 h / 0 - 20 °C / |Inert atmosphere View Scheme
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Rx-ID: 41493290 Find similar reactions
Das, Banibrata; Vedachalam, Seenuvasan; Luo, Dan; Antonio, Tamara; Reith, Maarten E. A.; Dutta, Aloke K.
Journal of Medicinal Chemistry, 2015 , vol. 58, # 23 p. 9179 - 9195 Title/Abstract Full Text View citing articles Show Details
272
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Rx-ID: 41493298 Find similar reactions
90%
in dichloromethane
T=0 - 20°C; 2 h; Inert atmosphere;
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Synthesize Find similar
Das, Banibrata; Vedachalam, Seenuvasan; Luo, Dan; Antonio, Tamara; Reith, Maarten E. A.; Dutta, Aloke K.
Journal of Medicinal Chemistry, 2015 , vol. 58, # 23 p. 9179 - 9195 Title/Abstract Full Text View citing articles Show Details
273
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Rx-ID: 41493289 Find similar reactions
90%
in dichloromethane
T=0 - 20°C; 2 h; Inert atmosphere;
Synthesize Find similar
Synthesize Find similar
Das, Banibrata; Vedachalam, Seenuvasan; Luo, Dan; Antonio, Tamara; Reith, Maarten E. A.; Dutta, Aloke K.
Journal of Medicinal Chemistry, 2015 , vol. 58, # 23 p. 9179 - 9195 Title/Abstract Full Text View citing articles Show Details
274
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Rx-ID: 41493359 Find similar reactions
Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride / dichloromethane / 48 h / 20 °C / |Inert atmosphere 2: dichloromethane / 2 h / 0 - 20 °C / |Inert atmosphere View Scheme
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Synthesize Find similar
Das, Banibrata; Vedachalam, Seenuvasan; Luo, Dan; Antonio, Tamara; Reith, Maarten E. A.; Dutta, Aloke K.
Journal of Medicinal Chemistry, 2015 , vol. 58, # 23 p. 9179 - 9195 Title/Abstract Full Text View citing articles Show Details
275
Synthesize Find similar
Rx-ID: 41493302 Find similar reactions
91%
in dichloromethane
T=0 - 20°C; 2 h; Inert atmosphere;
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Synthesize Find similar
Das, Banibrata; Vedachalam, Seenuvasan; Luo, Dan; Antonio, Tamara; Reith, Maarten E. A.; Dutta, Aloke K.
Journal of Medicinal Chemistry, 2015 , vol. 58, # 23 p. 9179 - 9195 Title/Abstract Full Text View citing articles Show Details
276
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Rx-ID: 41493361 Find similar reactions
Multi-step reaction with 2
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Das, Banibrata; Vedachalam, Seenuvasan; Luo, Dan; Antonio, Tamara; Reith, Maarten E. A.; Dutta, Aloke K.
steps 1: sodium tris(acetoxy)borohydride / dichloromethane / 48 h / 20 °C / |Inert atmosphere 2: dichloromethane / 2 h / 0 - 20 °C / |Inert atmosphere View Scheme
Journal of Medicinal Chemistry, 2015 , vol. 58, # 23 p. 9179 - 9195 Title/Abstract Full Text View citing articles Show Details