Query Query O
Results
Date
1 substances in Reaxys
2018-03-20 15h:15m:44s (EST)
OH
NH 2
1. Query
Search as: As drawn AND (IDE.XRN=2803961)
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
1/16
2018-03-20 15:16:13
Reaxys ID 2803961 View in Reaxys
O
1/1 CAS Registry Number: 17350-84-4 Chemical Name: (R)-2-amino-2-methyl-3-phenylpropanoic acid; (R)-α-methylphenylalaninne; (R)-(+)-2-methyl-3-phenylalanine; (R)-α-methyl-phenylalanine; (R)-α-methylphenylalanine; D-α-methylphenylalanine; α-methylphenylalanine Linear Structure Formula: C6H5CH2C2H3NH2CO2H Molecular Formula: C10H13NO2 Molecular Weight: 179.219 Type of Substance: isocyclic InChI Key: HYOWVAAEQCNGLE-SNVBAGLBSA-N Note:
OH NH 2
Substance Label (15) Label References 8.1.67
Patent; COMENTIS, INC.; ASTELLAS PHARMA INC.; BILCER, Geoffrey, M.; DEVASAMUDRAM, Thippeswamy; LILLY, John, C.; ANKALA, Sudha, V.; MOSKALEV, Nikolai, V.; LIU, Chunfeng; INOUE, Makoto; KAWAKAMI, Shimpei; MUNAKATA, Ryosuke; HAMAJIMA, Toshihiro; WO2012/54510; (2012); (A1) English, View in Reaxys
26
Carlier, Paul R.; Zhao, Hongwu; MacQuarrie-Hunter, Stephanie L.; DeGuzman, Joseph C.; Hsu, Danny C.; Journal of the American Chemical Society; vol. 128; nb. 47; (2006); p. 15215 - 15220, View in Reaxys
40
Patent; NAGASE and COMPANY, LTD.; EP1712549; (2006); (A1) English, View in Reaxys
4
Ichikawa, Yoshiyasu; Yamauchi, Eiji; Isobe, Minoru; Bioscience, Biotechnology and Biochemistry; vol. 69; nb. 5; (2005); p. 939 - 943, View in Reaxys
(R)-10
Lee, Mijoon; Kim, Dong H.; Bioorganic and Medicinal Chemistry; vol. 8; nb. 4; (2000); p. 815 - 823, View in Reaxys; Wu, Zhong-Liu; Li, Zu-Yi; Journal of Organic Chemistry; vol. 68; nb. 6; (2003); p. 2479 2482, View in Reaxys
(R)-9
Wu, Zhong-Liu; Li, Zu-Yi; Chemical Communications; nb. 3; (2003); p. 386 - 387, View in Reaxys
(R)-11
Carlier, Paul R.; Zhao, Hongwu; DeGuzman, Joe; Lam, Polo C.-H.; Journal of the American Chemical Society; vol. 125; nb. 38; (2003); p. 11482 - 11483, View in Reaxys
9
Wenglowsky, Steve; Journal of the American Chemical Society; vol. 120; nb. 48; (1998); p. 12468 - 12473, View in Reaxys; Coe, Diane M; Perciaccante, Rossana; Procopiou, Panayiotis A; Organic and biomolecular chemistry; vol. 1; nb. 7; (2003); p. 1106 - 1111, View in Reaxys
(R)-1
Shiraiwa, Tadashi; Suzuki, Masahiro; Sakai, Yoshio; Nagasawa, Hisashi; Takatani, Kazuhiro; Noshi, Daisuke; Yamanashi, Kenji; Chemical and pharmaceutical bulletin; vol. 50; nb. 10; (2002); p. 1362 - 1366, View in Reaxys
(R)-7
Casas, Jesus; Najera, Carmen; Sansano, Jose M.; Gonzalez, Jose; Saa, Jose M.; Vega, Manuel; Tetrahedron Asymmetry; vol. 12; nb. 5; (2001); p. 699 - 702, View in Reaxys
(R)-α-Me-Phe
Belokon, Yuri N.; Kochetkov, Konstantin A.; Churkina, Tatiana D.; Ikonnikov, Nikolai S.; Chesnokov, Alexey A.; Larionov, Oleg V.; Singh, Ishwar; Parmar, Virinder S.; Vyskocil, Stepan; Kagan, Henri B.; Journal of Organic Chemistry; vol. 65; nb. 21; (2000); p. 7041 - 7048, View in Reaxys
(R)-7c
Chinchilla, Rafael; Galindo, Nuria; Najera, Carmen; Synthesis; nb. 4; (1999); p. 704 - 717, View in Reaxys
37
Vedejs; Fields; Hayashi; Hitchcock; Powell; Schrimpf; Journal of the American Chemical Society; vol. 121; nb. 11; (1999); p. 2460 - 2470, View in Reaxys
11-free base
Carloni, Armando; Porzi, Gianni; Sandri, Sergio; Tetrahedron Asymmetry; vol. 9; nb. 17; (1998); p. 2987 2998, View in Reaxys
1
Subramanian, Pullachipatti K.; Woodard, Ronald W.; Journal of Organic Chemistry; vol. 52; nb. 1; (1987); p. 15 - 18, View in Reaxys
Patent-Specific Data (1) References Patent; Nagase Co., Ltd.; RIKEN; Yamamoto, Kenichiro; Kodama, Kazuya; Anzai, Kinsei; Matsuyama, Keisuke; Sasano, Arisue; Hashizume, Yoshinobu; Hume, William Yuwan; Yashio, Keiji; Nozaki, Satoshi; (75 pag.); JP2016/74605; (2016); (A) Japanese, View in Reaxys Druglikeness (1) 1 of 1
LogP
-1.269
H Bond Donors
2
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
2/16
2018-03-20 15:16:13
H Bond Acceptors
3
Rotatable Bonds
3
TPSA
63.32
Lipinski Number
4
Veber Number
2
Derivative (5) Comment (Derivative)
Derivative
References
(R)-α-methyl-phe- Alonso, Francisco; Davies, Stephen G.; Elend, Almut S.; Haggitt, Jane L.; Journal of nylalanine hydro- the Chemical Society - Perkin Transactions 1; nb. 2; (1998); p. 257 - 264, View in Reaxys chloride (R)-α-methyl-phe- Carloni, Armando; Porzi, Gianni; Sandri, Sergio; Tetrahedron Asymmetry; vol. 9; nb. nylalanine hydro- 17; (1998); p. 2987 - 2998, View in Reaxys chloride (R)-α-methyl-phe- Alonso; Davies; Tetrahedron Asymmetry; vol. 6; nb. 2; (1995); p. 353 - 356, nylalanine hydro- View in Reaxys chloride (R)-α-methyl-phe- Belokon', Yuri N.; Chernoglazova, Nina I.; Kochetkov, Constantin A.; Garbalinnylalanine hydro- skaya, Natalia S.; Belikov, Vasili M.; Journal of the Chemical Society, Chemical Comchloride munications; nb. 3; (1985); p. 171 - 172, View in Reaxys Hydrochlorid: <α>(D)20 = +3.4grad (H2O) Purification (1) Purification (method) via reaction with (-)-chlocyphos
Kolb; Barth; Tetrahedron Letters; (1979); p. 2999,3000,3001, View in Reaxys
References Hulst, Ron; Broxterman, Quirinus B.; Kamphuis, Johan; Formaggio, Fernando; Crisma, Marco; Toniolo, Claudio; Kellogg, Richard M.; Tetrahedron Asymmetry; vol. 8; nb. 12; (1997); p. 1987 - 1999, View in Reaxys
Melting Point (6) 1 of 6
Melting Point [°C]
277 - 279
Xu, Peng-Fei; Li, Shuo; Lu, Ta-Jung; Wu, Chen-Chang; Fan, Botao; Golfis, Georgia; Journal of Organic Chemistry; vol. 71; nb. 12; (2006); p. 4364 - 4373, View in Reaxys 2 of 6
Melting Point [°C]
277 - 279
Solvent (Melting Point)
H2O
Comment (Melting Point)
Decomposition
Shiraiwa, Tadashi; Suzuki, Masahiro; Sakai, Yoshio; Nagasawa, Hisashi; Takatani, Kazuhiro; Noshi, Daisuke; Yamanashi, Kenji; Chemical and pharmaceutical bulletin; vol. 50; nb. 10; (2002); p. 1362 - 1366, View in Reaxys 3 of 6
Melting Point [°C]
288 - 290
Solvent (Melting Point)
propan-2-ol; H2O
Belokon, Yuri N.; Kochetkov, Konstantin A.; Churkina, Tatiana D.; Ikonnikov, Nikolai S.; Chesnokov, Alexey A.; Larionov, Oleg V.; Singh, Ishwar; Parmar, Virinder S.; Vyskocil, Stepan; Kagan, Henri B.; Journal of Organic Chemistry; vol. 65; nb. 21; (2000); p. 7041 - 7048, View in Reaxys 4 of 6
Melting Point [°C]
288 - 290
Solvent (Melting Point)
propan-2-ol; H2O
Belokon'; Kochetkov; Churkina; Ikonnikov; Chesnokov; Larionov; Kagan; Russian Chemical Bulletin; vol. 48; nb. 5; (1999); p. 917 - 923, View in Reaxys 5 of 6
Melting Point [°C]
262 - 263
Comment (Melting Point)
Decomposition
Olma; Polish Journal of Chemistry; vol. 70; nb. 11; (1996); p. 1442 - 1447, View in Reaxys
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
3/16
2018-03-20 15:16:13
6 of 6
Melting Point [°C]
279 - 280
Comment (Melting Point)
Decomposition
Turk; Panse; Marshall; The Journal of organic chemistry; vol. 40; nb. 7; (1975); p. 953 - 955, View in Reaxys Chromatographic Data (2) Chromatographic Location data HPLC (High performance liquid chromatography)
Paragraph 0133
References Patent; Nagase Co., Ltd.; RIKEN; Yamamoto, Kenichiro; Kodama, Kazuya; Anzai, Kinsei; Matsuyama, Keisuke; Sasano, Arisue; Hashizume, Yoshinobu; Hume, William Yuwan; Yashio, Keiji; Nozaki, Satoshi; (75 pag.); JP2016/74605; (2016); (A) Japanese, View in Reaxys
TLC (Thin layer chromatography)
Remelli, Maurizio; Faccini, Stefania; Conato, Chiara; Chirality; vol. 26; nb. 6; (2014); p. 313 - 318, View in Reaxys
Crystal Property Description (1) Colour & Other Location Properties
References
white
supporting information
Green, Jonathan E.; Bender, David M.; Jackson, Stona; O'donnell, Martin J.; Mccarthy, James R.; Organic Letters; vol. 11; nb. 4; (2009); p. 807 - 810, View in Reaxys
Decomposition (1) 1 of 1
Decomposition [°C]
230 - 233
Location
supporting information
Green, Jonathan E.; Bender, David M.; Jackson, Stona; O'donnell, Martin J.; Mccarthy, James R.; Organic Letters; vol. 11; nb. 4; (2009); p. 807 - 810, View in Reaxys Optical Rotatory Dispersion (1) Comment (Optical References Rotatory Dispersion) 270000 - 700000 nm
Terashima,S. et al.; Chemical and Pharmaceutical Bulletin; vol. 14; (1966); p. 1138 - 1143, View in Reaxys
Optical Rotatory Power (24) 1 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
1 g/100ml
Solvent (Optical Rotatory Power)
water
Optical Rotatory Power [deg]
13.2
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
25
Location
supporting information
Green, Jonathan E.; Bender, David M.; Jackson, Stona; O'donnell, Martin J.; Mccarthy, James R.; Organic Letters; vol. 11; nb. 4; (2009); p. 807 - 810, View in Reaxys 2 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
1.04 g/100ml
Solvent (Optical Rotatory Power)
H2O
Optical Rotatory Power [deg]
21.5
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
4/16
2018-03-20 15:16:13
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
22
Xu, Peng-Fei; Li, Shuo; Lu, Ta-Jung; Wu, Chen-Chang; Fan, Botao; Golfis, Georgia; Journal of Organic Chemistry; vol. 71; nb. 12; (2006); p. 4364 - 4373, View in Reaxys 3 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
0.12 g/100ml
Solvent (Optical Rotatory Power)
H2O
Optical Rotatory Power [deg]
22.5
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
25
Carlier, Paul R.; Zhao, Hongwu; MacQuarrie-Hunter, Stephanie L.; DeGuzman, Joseph C.; Hsu, Danny C.; Journal of the American Chemical Society; vol. 128; nb. 47; (2006); p. 15215 - 15220, View in Reaxys 4 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
0.73 g/100ml
Solvent (Optical Rotatory Power)
H2O
Optical Rotatory Power [deg]
21.8
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
17
Wu, Zhong-Liu; Li, Zu-Yi; Journal of Organic Chemistry; vol. 68; nb. 6; (2003); p. 2479 - 2482, View in Reaxys 5 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
1.25 g/100ml
Solvent (Optical Rotatory Power)
H2O
Optical Rotatory Power [deg]
25.6
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
26
Carlier, Paul R.; Zhao, Hongwu; DeGuzman, Joe; Lam, Polo C.-H.; Journal of the American Chemical Society; vol. 125; nb. 38; (2003); p. 11482 - 11483, View in Reaxys 6 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
1.00 g/100ml
Length of Path [cm]
5
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
5/16
2018-03-20 15:16:13
Solvent (Optical Rotatory Power)
H2O
Optical Rotatory Power [deg]
20.2
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
20
Shiraiwa, Tadashi; Suzuki, Masahiro; Sakai, Yoshio; Nagasawa, Hisashi; Takatani, Kazuhiro; Noshi, Daisuke; Yamanashi, Kenji; Chemical and pharmaceutical bulletin; vol. 50; nb. 10; (2002); p. 1362 - 1366, View in Reaxys 7 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
0.2 g/100ml
Solvent (Optical Rotatory Power)
H2O
Optical Rotatory Power [deg]
-17.8
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
25
Belokon, Yuri N.; Kochetkov, Konstantin A.; Churkina, Tatiana D.; Ikonnikov, Nikolai S.; Chesnokov, Alexey A.; Larionov, Oleg V.; Singh, Ishwar; Parmar, Virinder S.; Vyskocil, Stepan; Kagan, Henri B.; Journal of Organic Chemistry; vol. 65; nb. 21; (2000); p. 7041 - 7048, View in Reaxys 8 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
1 g/100ml
Solvent (Optical Rotatory Power)
H2O
Optical Rotatory Power [deg]
21.6
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
25
Chinchilla, Rafael; Galindo, Nuria; Najera, Carmen; Synthesis; nb. 4; (1999); p. 704 - 717, View in Reaxys 9 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
0.1 g/100ml
Solvent (Optical Rotatory Power)
methanol
Optical Rotatory Power [deg]
21
Wavelength (Optical Ro- 589 tatory Power) [nm] Vedejs; Fields; Hayashi; Hitchcock; Powell; Schrimpf; Journal of the American Chemical Society; vol. 121; nb. 11; (1999); p. 2460 - 2470, View in Reaxys 10 of 24
Type (Optical Rotatory Power)
[alpha]
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
6/16
2018-03-20 15:16:13
Concentration (Optical Rotatory Power)
0.2 g/100ml
Solvent (Optical Rotatory Power)
H2O
Optical Rotatory Power [deg]
17.8
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
25
Comment (Optical Rota- ,single stereoisomer tory Power) Belokon'; Kochetkov; Churkina; Ikonnikov; Chesnokov; Larionov; Kagan; Russian Chemical Bulletin; vol. 48; nb. 5; (1999); p. 917 - 923, View in Reaxys 11 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
0.1 g/100ml
Solvent (Optical Rotatory Power)
methanol
Optical Rotatory Power [deg]
17
Wavelength (Optical Ro- 578 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
25
Alonso, Francisco; Davies, Stephen G.; Elend, Almut S.; Haggitt, Jane L.; Journal of the Chemical Society Perkin Transactions 1; nb. 2; (1998); p. 257 - 264, View in Reaxys 12 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
1 g/100ml
Length of Path [cm]
10
Solvent (Optical Rotatory Power)
aq. HCl
Optical Rotatory Power [deg]
6.2
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
20
Olma; Polish Journal of Chemistry; vol. 70; nb. 11; (1996); p. 1442 - 1447, View in Reaxys 13 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
0.51 g/100ml
Solvent (Optical Rotatory Power)
H2O
Optical Rotatory Power [deg]
19.01
Wavelength (Optical Ro- 589 tatory Power) [nm]
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
7/16
2018-03-20 15:16:13
Temperature (Optical Rotatory Power) [°C]
20
Davis, Franklin A.; Liu, Hu; Reddy, G. Venkat; Tetrahedron Letters; vol. 37; nb. 31; (1996); p. 5473 - 5476, View in Reaxys 14 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
0.11 g/100ml
Length of Path [cm]
10
Solvent (Optical Rotatory Power)
methanol
Optical Rotatory Power [deg]
20
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
22
Studer, Armido; Seebach, Dieter; Liebigs Annalen; nb. 2; (1995); p. 217 - 222, View in Reaxys 15 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
0.1 g/100ml
Solvent (Optical Rotatory Power)
methanol
Optical Rotatory Power [deg]
17
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
25
Alonso; Davies; Tetrahedron Asymmetry; vol. 6; nb. 2; (1995); p. 353 - 356, View in Reaxys 16 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
1 g/100ml
Solvent (Optical Rotatory Power)
H2O
Optical Rotatory Power [deg]
21
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
25
Cativiela; Diaz-de-Villegas; Galvez; Tetrahedron Asymmetry; vol. 5; nb. 2; (1994); p. 261 - 268, View in Reaxys 17 of 24
Type (Optical Rotatory Power)
alpha
Concentration (Optical Rotatory Power)
5 g/l
Length of Path [cm]
10
Solvent (Optical Rotatory Power)
various solvent(s)
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
8/16
2018-03-20 15:16:13
Optical Rotatory Power [deg]
4.2
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
25
Belokon, Yuri N.; Bakhmutov, Vladimir I.; Chernoglazova, Nina I.; Kochetkov, Konstantin A.; Vitt, Sergei V.; et al.; Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999); (1988); p. 305 - 312, View in Reaxys 18 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
1.0 g/100ml
Solvent (Optical Rotatory Power)
H2O
Optical Rotatory Power [deg]
20.5
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
20
Ojima, Iwao; Chen, Hauh-Jyun C.; Qiu, Xiaogang; Tetrahedron; vol. 44; nb. 17; (1988); p. 5307 - 5318, View in Reaxys 19 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
1.01 g/100ml
Solvent (Optical Rotatory Power)
aq. HCl
Optical Rotatory Power [deg]
4.2
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
25
Belokon', Yu. N.; Chernoglazova, N. I.; Bakhmutov, V. I.; Garbalinskaya, N. S.; Belikov, V. M.; Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation); vol. 36; nb. 12; (1987); p. 2595 - 2601; Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya; nb. 12; (1987); p. 2798 - 2804, View in Reaxys 20 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
0.1 g/100ml
Solvent (Optical Rotatory Power)
methanol
Optical Rotatory Power [deg]
20
Wavelength (Optical Ro- 578 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
24
Seebach, Dieter; Fadel, Antoine; Helvetica Chimica Acta; vol. 68; (1985); p. 1243 - 1250, View in Reaxys 21 of 24
Type (Optical Rotatory Power)
[alpha]
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
9/16
2018-03-20 15:16:13
Concentration (Optical Rotatory Power)
0.1 g/100ml
Solvent (Optical Rotatory Power)
methanol
Optical Rotatory Power [deg]
19
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
25
Karady, Sandor; Amato, Joseph S.; Weinstock, Leonard M.; Tetrahedron Letters; vol. 25; nb. 39; (1984); p. 4337 - 4340, View in Reaxys 22 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
1.0 g/100ml
Solvent (Optical Rotatory Power)
H2O
Optical Rotatory Power [deg]
19.3
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
25
Anantharamaiah, G. M.; Roeske, Roger W.; Tetrahedron Letters; vol. 23; nb. 33; (1982); p. 3335 - 3336, View in Reaxys 23 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
0.716 g/100ml
Solvent (Optical Rotatory Power)
H2O
Optical Rotatory Power [deg]
47.8
Wavelength (Optical Ro- 300 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
25
Turk; Panse; Marshall; The Journal of organic chemistry; vol. 40; nb. 7; (1975); p. 953 - 955, View in Reaxys 24 of 24
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
1.066 g/100ml
Solvent (Optical Rotatory Power)
H2O
Optical Rotatory Power [deg]
20.1
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
20
Kobayashi,M. et al.; Chemical and Pharmaceutical Bulletin; vol. 20; (1972); p. 1898 - 1905, View in Reaxys NMR Spectroscopy (28)
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
10/16
2018-03-20 15:16:13
1 of 28
Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- water-d2 scopy) Frequency (NMR Spectroscopy) [MHz]
400
Location
supporting information
Green, Jonathan E.; Bender, David M.; Jackson, Stona; O'donnell, Martin J.; Mccarthy, James R.; Organic Letters; vol. 11; nb. 4; (2009); p. 807 - 810, View in Reaxys 2 of 28
Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)
13C
Solvents (NMR Spectro- water-d2 scopy) Location
supporting information
Green, Jonathan E.; Bender, David M.; Jackson, Stona; O'donnell, Martin J.; Mccarthy, James R.; Organic Letters; vol. 11; nb. 4; (2009); p. 807 - 810, View in Reaxys 3 of 28
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- D2O scopy) Frequency (NMR Spectroscopy) [MHz]
400
Xu, Peng-Fei; Li, Shuo; Lu, Ta-Jung; Wu, Chen-Chang; Fan, Botao; Golfis, Georgia; Journal of Organic Chemistry; vol. 71; nb. 12; (2006); p. 4364 - 4373, View in Reaxys; Ichikawa, Yoshiyasu; Yamauchi, Eiji; Isobe, Minoru; Bioscience, Biotechnology and Biochemistry; vol. 69; nb. 5; (2005); p. 939 - 943, View in Reaxys 4 of 28
Nucleus (NMR Spectroscopy)
1H
Coupling Nuclei
1H
Solvents (NMR Spectro- D2O scopy) Frequency (NMR Spectroscopy) [MHz]
400
Xu, Peng-Fei; Li, Shuo; Lu, Ta-Jung; Wu, Chen-Chang; Fan, Botao; Golfis, Georgia; Journal of Organic Chemistry; vol. 71; nb. 12; (2006); p. 4364 - 4373, View in Reaxys; Ichikawa, Yoshiyasu; Yamauchi, Eiji; Isobe, Minoru; Bioscience, Biotechnology and Biochemistry; vol. 69; nb. 5; (2005); p. 939 - 943, View in Reaxys 5 of 28
Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- d(4)-methanol scopy) Frequency (NMR Spectroscopy) [MHz]
400
Original Text (NMR Spectroscopy)
1H
Comment (NMR Spectroscopy)
Signals given
NMR (d4- MeOH, 400 Mhz) δ 7.25-7.17 (m, 3H), 7.12 (d, J= 6.6 Hz, 2H), 3.27 (d, J= 13.4 Hz, 1H), 3.15 (d, J= 13.4 Hz, 1H), 1.45 (s, 9H), 1.39 (s, 3H)
Patent; MERCK and CO., INC.; WO2006/78576; (2006); (A2) English, View in Reaxys
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
11/16
2018-03-20 15:16:13
6 of 28
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
13C
Solvents (NMR Spectro- D2O scopy) Frequency (NMR Spectroscopy) [MHz]
100
Ichikawa, Yoshiyasu; Yamauchi, Eiji; Isobe, Minoru; Bioscience, Biotechnology and Biochemistry; vol. 69; nb. 5; (2005); p. 939 - 943, View in Reaxys 7 of 28
Nucleus (NMR Spectroscopy)
1H
Coupling Nuclei
1H
Solvents (NMR Spectro- CDCl3 scopy) Frequency (NMR Spectroscopy) [MHz]
300
Wu, Zhong-Liu; Li, Zu-Yi; Journal of Organic Chemistry; vol. 68; nb. 6; (2003); p. 2479 - 2482, View in Reaxys 8 of 28
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- CDCl3 scopy) Frequency (NMR Spectroscopy) [MHz]
300
Wu, Zhong-Liu; Li, Zu-Yi; Journal of Organic Chemistry; vol. 68; nb. 6; (2003); p. 2479 - 2482, View in Reaxys 9 of 28
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- dimethylsulfoxide-d6 scopy) Carlier, Paul R.; Zhao, Hongwu; DeGuzman, Joe; Lam, Polo C.-H.; Journal of the American Chemical Society; vol. 125; nb. 38; (2003); p. 11482 - 11483, View in Reaxys 10 of 28
Nucleus (NMR Spectroscopy)
1H
Coupling Nuclei
1H
Solvents (NMR Spectro- dimethylsulfoxide-d6 scopy) Carlier, Paul R.; Zhao, Hongwu; DeGuzman, Joe; Lam, Polo C.-H.; Journal of the American Chemical Society; vol. 125; nb. 38; (2003); p. 11482 - 11483, View in Reaxys 11 of 28
Description (NMR Spec- Spectrum troscopy) Nucleus (NMR Spectroscopy)
1H
Carlier, Paul R.; Zhao, Hongwu; DeGuzman, Joe; Lam, Polo C.-H.; Journal of the American Chemical Society; vol. 125; nb. 38; (2003); p. 11482 - 11483, View in Reaxys 12 of 28
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
1H
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
12/16
2018-03-20 15:16:13
Solvents (NMR Spectro- tetradeuteriomethanol scopy) Frequency (NMR Spectroscopy) [MHz]
400
Coe, Diane M; Perciaccante, Rossana; Procopiou, Panayiotis A; Organic and biomolecular chemistry; vol. 1; nb. 7; (2003); p. 1106 - 1111, View in Reaxys 13 of 28
Nucleus (NMR Spectroscopy)
1H
Coupling Nuclei
1H
Solvents (NMR Spectro- tetradeuteriomethanol scopy) Frequency (NMR Spectroscopy) [MHz]
400
Coe, Diane M; Perciaccante, Rossana; Procopiou, Panayiotis A; Organic and biomolecular chemistry; vol. 1; nb. 7; (2003); p. 1106 - 1111, View in Reaxys 14 of 28
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
13C
Solvents (NMR Spectro- D2O scopy) Frequency (NMR Spectroscopy) [MHz]
67.5
Shiraiwa, Tadashi; Suzuki, Masahiro; Sakai, Yoshio; Nagasawa, Hisashi; Takatani, Kazuhiro; Noshi, Daisuke; Yamanashi, Kenji; Chemical and pharmaceutical bulletin; vol. 50; nb. 10; (2002); p. 1362 - 1366, View in Reaxys 15 of 28
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- D2O scopy) Frequency (NMR Spectroscopy) [MHz]
270
Shiraiwa, Tadashi; Suzuki, Masahiro; Sakai, Yoshio; Nagasawa, Hisashi; Takatani, Kazuhiro; Noshi, Daisuke; Yamanashi, Kenji; Chemical and pharmaceutical bulletin; vol. 50; nb. 10; (2002); p. 1362 - 1366, View in Reaxys 16 of 28
Nucleus (NMR Spectroscopy)
1H
Coupling Nuclei
1H
Solvents (NMR Spectro- D2O scopy) Frequency (NMR Spectroscopy) [MHz]
270
Shiraiwa, Tadashi; Suzuki, Masahiro; Sakai, Yoshio; Nagasawa, Hisashi; Takatani, Kazuhiro; Noshi, Daisuke; Yamanashi, Kenji; Chemical and pharmaceutical bulletin; vol. 50; nb. 10; (2002); p. 1362 - 1366, View in Reaxys 17 of 28
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- CDCl3 scopy) Frequency (NMR Spectroscopy) [MHz]
200
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
13/16
2018-03-20 15:16:13
Belokon, Yuri N.; Kochetkov, Konstantin A.; Churkina, Tatiana D.; Ikonnikov, Nikolai S.; Chesnokov, Alexey A.; Larionov, Oleg V.; Singh, Ishwar; Parmar, Virinder S.; Vyskocil, Stepan; Kagan, Henri B.; Journal of Organic Chemistry; vol. 65; nb. 21; (2000); p. 7041 - 7048, View in Reaxys 18 of 28
Nucleus (NMR Spectroscopy)
1H
Coupling Nuclei
1H
Solvents (NMR Spectro- CDCl3 scopy) Frequency (NMR Spectroscopy) [MHz]
200
Belokon, Yuri N.; Kochetkov, Konstantin A.; Churkina, Tatiana D.; Ikonnikov, Nikolai S.; Chesnokov, Alexey A.; Larionov, Oleg V.; Singh, Ishwar; Parmar, Virinder S.; Vyskocil, Stepan; Kagan, Henri B.; Journal of Organic Chemistry; vol. 65; nb. 21; (2000); p. 7041 - 7048, View in Reaxys 19 of 28
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
1H
Coupling Nuclei
1H
Solvents (NMR Spectro- D2O scopy) Chinchilla, Rafael; Galindo, Nuria; Najera, Carmen; Synthesis; nb. 4; (1999); p. 704 - 717, View in Reaxys 20 of 28
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- CDCl3 scopy) Frequency (NMR Spectroscopy) [MHz]
200
Comment (NMR Spectroscopy)
single stereoisomer
Belokon'; Kochetkov; Churkina; Ikonnikov; Chesnokov; Larionov; Kagan; Russian Chemical Bulletin; vol. 48; nb. 5; (1999); p. 917 - 923, View in Reaxys 21 of 28
Nucleus (NMR Spectroscopy)
1H
Coupling Nuclei
1H
Solvents (NMR Spectro- CDCl3 scopy) Frequency (NMR Spectroscopy) [MHz]
200
Comment (NMR Spectroscopy)
single stereoisomer
Belokon'; Kochetkov; Churkina; Ikonnikov; Chesnokov; Larionov; Kagan; Russian Chemical Bulletin; vol. 48; nb. 5; (1999); p. 917 - 923, View in Reaxys 22 of 28
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- various solvent(s); D2O scopy) Belokon, Yuri N.; Bakhmutov, Vladimir I.; Chernoglazova, Nina I.; Kochetkov, Konstantin A.; Vitt, Sergei V.; et al.; Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999); (1988);
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
14/16
2018-03-20 15:16:13
p. 305 - 312, View in Reaxys; Olma; Polish Journal of Chemistry; vol. 70; nb. 11; (1996); p. 1442 - 1447, View in Reaxys 23 of 28
Description (NMR Spec- Spin-spin coupling constants troscopy) Comment (NMR Spectroscopy)
1H-1H. Solvent(s): further solvent(s), D2O
Belokon, Yuri N.; Bakhmutov, Vladimir I.; Chernoglazova, Nina I.; Kochetkov, Konstantin A.; Vitt, Sergei V.; et al.; Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999); (1988); p. 305 - 312, View in Reaxys; Olma; Polish Journal of Chemistry; vol. 70; nb. 11; (1996); p. 1442 - 1447, View in Reaxys 24 of 28
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- D2O scopy) Ojima, Iwao; Chen, Hauh-Jyun C.; Qiu, Xiaogang; Tetrahedron; vol. 44; nb. 17; (1988); p. 5307 - 5318, View in Reaxys; Belokon', Yu. N.; Chernoglazova, N. I.; Bakhmutov, V. I.; Garbalinskaya, N. S.; Belikov, V. M.; Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation); vol. 36; nb. 12; (1987); p. 2595 - 2601; Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya; nb. 12; (1987); p. 2798 - 2804, View in Reaxys; Seebach, Dieter; Fadel, Antoine; Helvetica Chimica Acta; vol. 68; (1985); p. 1243 - 1250, View in Reaxys; Cativiela; Diaz-de-Villegas; Galvez; Tetrahedron Asymmetry; vol. 5; nb. 2; (1994); p. 261 - 268, View in Reaxys 25 of 28
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
13C
Solvents (NMR Spectro- D2O scopy) Cativiela; Diaz-de-Villegas; Galvez; Tetrahedron Asymmetry; vol. 5; nb. 2; (1994); p. 261 - 268, View in Reaxys 26 of 28
Description (NMR Spec- Spin-spin coupling constants troscopy) Solvents (NMR Spectro- D2O scopy) Comment (NMR Spectroscopy)
1H-1H
Ojima, Iwao; Chen, Hauh-Jyun C.; Qiu, Xiaogang; Tetrahedron; vol. 44; nb. 17; (1988); p. 5307 - 5318, View in Reaxys; Belokon', Yu. N.; Chernoglazova, N. I.; Bakhmutov, V. I.; Garbalinskaya, N. S.; Belikov, V. M.; Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation); vol. 36; nb. 12; (1987); p. 2595 - 2601; Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya; nb. 12; (1987); p. 2798 - 2804, View in Reaxys; Seebach, Dieter; Fadel, Antoine; Helvetica Chimica Acta; vol. 68; (1985); p. 1243 - 1250, View in Reaxys; Cativiela; Diaz-de-Villegas; Galvez; Tetrahedron Asymmetry; vol. 5; nb. 2; (1994); p. 261 - 268, View in Reaxys 27 of 28
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- D2O scopy) Temperature (NMR Spectroscopy) [°C]
35
Kabuto, Kuninobu; Sasaki, Yoichi; Tetrahedron Letters; vol. 31; nb. 7; (1990); p. 1031 - 1034, View in Reaxys 28 of 28
Description (NMR Spec- NMR with shift reagents troscopy) Kabuto, Kuninobu; Sasaki, Yoichi; Tetrahedron Letters; vol. 31; nb. 7; (1990); p. 1031 - 1034, View in Reaxys
IR Spectroscopy (3)
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
15/16
2018-03-20 15:16:13
1 of 3
Description (IR Spectroscopy)
Mid IR (MIR); Bands
Solvent (IR Spectroscopy)
potassium bromide
Location
supporting information
Green, Jonathan E.; Bender, David M.; Jackson, Stona; O'donnell, Martin J.; Mccarthy, James R.; Organic Letters; vol. 11; nb. 4; (2009); p. 807 - 810, View in Reaxys 2 of 3
Description (IR Spectroscopy)
Bands
Solvent (IR Spectroscopy)
KBr
Shiraiwa, Tadashi; Suzuki, Masahiro; Sakai, Yoshio; Nagasawa, Hisashi; Takatani, Kazuhiro; Noshi, Daisuke; Yamanashi, Kenji; Chemical and pharmaceutical bulletin; vol. 50; nb. 10; (2002); p. 1362 - 1366, View in Reaxys; Wu, Zhong-Liu; Li, Zu-Yi; Journal of Organic Chemistry; vol. 68; nb. 6; (2003); p. 2479 - 2482, View in Reaxys; Ichikawa, Yoshiyasu; Yamauchi, Eiji; Isobe, Minoru; Bioscience, Biotechnology and Biochemistry; vol. 69; nb. 5; (2005); p. 939 - 943, View in Reaxys 3 of 3
Description (IR Spectroscopy)
Bands
Comment (IR Spectroscopy)
3550 - 1654 cm**(-1)
Cativiela; Diaz-de-Villegas; Galvez; Tetrahedron Asymmetry; vol. 5; nb. 2; (1994); p. 261 - 268, View in Reaxys Mass Spectrometry (3) Description (Mass Location Spectrometry) HRMS (High resolution mass spectrometry); ESI (Electrospray ionisation)
supporting information
LCMS (Liquid chromatography mass spectrometry)
Comment (Mass Spectrometry)
References
mol peak
Green, Jonathan E.; Bender, David M.; Jackson, Stona; O'donnell, Martin J.; Mccarthy, James R.; Organic Letters; vol. 11; nb. 4; (2009); p. 807 - 810, View in Reaxys
Molecular peak
Patent; MERCK and CO., INC.; WO2006/78576; (2006); (A2) English, View in Reaxys
spectrum
Seebach, Dieter; Fadel, Antoine; Helvetica Chimica Acta; vol. 68; (1985); p. 1243 - 1250, View in Reaxys
UV/VIS Spectroscopy (2) 1 of 2
Absorption Maxima (UV/ 252; 258; 264 VIS) [nm] Ext./Abs. Coefficient [l·mol-1cm-1]
139; 178; 135
Belokon, Yuri N.; Kochetkov, Konstantin A.; Churkina, Tatiana D.; Ikonnikov, Nikolai S.; Chesnokov, Alexey A.; Larionov, Oleg V.; Singh, Ishwar; Parmar, Virinder S.; Vyskocil, Stepan; Kagan, Henri B.; Journal of Organic Chemistry; vol. 65; nb. 21; (2000); p. 7041 - 7048, View in Reaxys 2 of 2
Solvent (UV/VIS Spectroscopy)
H2O
Comment (UV/VIS Spectroscopy)
single stereoisomer
Absorption Maxima (UV/ 252; 258; 264 VIS) [nm] Ext./Abs. Coefficient [l·mol-1cm-1]
139; 178; 135
Belokon'; Kochetkov; Churkina; Ikonnikov; Chesnokov; Larionov; Kagan; Russian Chemical Bulletin; vol. 48; nb. 5; (1999); p. 917 - 923, View in Reaxys
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
16/16
2018-03-20 15:16:13