Acetone (2-Propanone; Propan-2-one) [C3H6O] by Asch

Reaxys

PubChem

eMolecules

LabNetwork

Bioactivities (515)

SigmaAldrich

Reactions (45447)

Substances (1)

Structure

Targets (32)

Citations (40358)

N° of preparations All Preps | All Reactions

Structure/Compound Data Chemical Name: acetone

3920 prep out of 45447 reactions.

Reaxys Registry Number: 635680

CAS Registry Number: 67-64-1 Type of Substance: acyclic Molecular Formula: C3H6O Linear Structure Formula: CO(CH3)2 Molecular Weight: 58.08 InChI Key: CSCPPACGZOOCGX-UHFFFAOYSA-N

Available Data

Target

N° of ref.

Druglikeness

Bioactivity

Identification Physical Data (4116) Spectra (659) Other Data (988)

Show Targets

40358

Synthesize | Hide Details Find similar Chemical Names and Synonyms acetone, dimethyl ketone, propanone Druglikeness Bioactivity In vitro: Efficacy (303) Quantitative Results pX

Parameter EC50

Value (qual)

Value (quant)

Unit

16395

mg/L

Action on Target

Target

Tissue/Organ

Cell

Bioassay

Dose

Effect

Reference (expand all/collapse all)

In Vitro (others)

0 mg/L

Cytotoxic

Environmental Toxicology...

Title/Abstract Full Text View citing articles Show Details

Bogaerts, Philippe; Senaud, Jean; Bohatier, Jacques

Environmental Toxicology and Chemistry, 1998 , vol. 17, # 8 p. 1600 - 1605 Title/Abstract Full Text View citing articles Show Details

LC50

64.3

g/L

In Vitro (others)

Toxic : Acute

Environmental Toxicology...

Title/Abstract Full Text View citing articles Show Details

Crisinel; Delaunay; Rossel; Tarradellas; Meyer; Saiah; Vogel; Delisle; Blaise

Environmental Toxicology and Water Quality, 1994 , vol. 9, # 4 p. 317 - 326 Title/Abstract Full Text View citing articles Show Details

% Inhibition

liver

Enzymology inhibition

2.50000 %_(v/v)

Type: Clinical Pharmacol...

Title/Abstract Full Text Show Details

Type: Clinical Pharmacology Biopharmaceutics Review, Lab: NDA021976, Owner: TIBOTEC, Number: 000, Revision: 23.06.2006 00:00:00 2006 Title/Abstract Full Text Show Details

% Inhibition

liver

Enzymology inhibition

2.50000 %_(v/v)

Type: Clinical Pharmacol...

Title/Abstract Full Text Show Details

Type: Clinical Pharmacology Biopharmaceutics Review, Lab: NDA021976, Owner: TIBOTEC, Number: 000, Revision: 23.06.2006 00:00:00 2006 Title/Abstract Full Text Show Details

EC50

18984

mg/L

In Vitro (others)

Toxic

Ecotoxicology and Enviro...

Title/Abstract Full Text View citing articles Show Details

Tahedl, Harald; Haeder, Donat-P.

Ecotoxicology and Environmental Safety, 2001 , vol. 48, # 2 p. 161 - 169 Title/Abstract Full Text View citing articles Show Details

EC50

Agonist

Hydroxycarboxylic acid receptor 1 [human]:Wild

CHOK1

GTPgammaS

Biochemical and Biophysi...

Title/Abstract Full Text View citing articles Show Details

Cai, Tian-Quan; Ren, Ning; Jin, Lan; Cheng, Kang; Kash, Shera; Chen, Ruoping; Wright, Samuel D.; Taggart, Andrew K.P.; Waters, M. Gerard.

Biochemical and Biophysical Research Communications, 2008 , vol. 377, # 3 p. 987 - 991 Title/Abstract Full Text View citing articles Show Details

EC50

14283

mg/L

In Vitro (others)

Toxic

Environmental Toxicology...

Title/Abstract Full Text View citing articles Show Details

In Vitro (others)

Toxic

Environmental Toxicology...

Title/Abstract Full Text View citing articles Show Details

In Vitro (others)

Toxic

Water Research, 1998 , ...

Title/Abstract Full Text View citing articles Show Details

In Vitro (others)

Toxic

Water Research, 1998 , ...

Title/Abstract Full Text View citing articles Show Details

In Vitro (others)

Antiproliferative

Environmental Pollution,...

Title/Abstract Full Text View citing articles Show Details

Chen; Chiou

Environmental Toxicology and Water Quality, 1995 , vol. 10, # 2 p. 97 - 106 Title/Abstract Full Text View citing articles Show Details

EC50

15159

mg/L

Chen; Chiou

Environmental Toxicology and Water Quality, 1995 , vol. 10, # 2 p. 97 - 106 Title/Abstract Full Text View citing articles Show Details

IC50

48619

mg/L

Xu; Nirmalakhandan

Water Research, 1998 , vol. 32, # 8 p. 2391 - 2399 Title/Abstract Full Text View citing articles Show Details

IC50

48000

mg/L

Xu; Nirmalakhandan

Water Research, 1998 , vol. 32, # 8 p. 2391 - 2399 Title/Abstract Full Text View citing articles Show Details

4.58

EC50

1.52

mg/L

Ma, Jianyi; Chen, Jianmeng

Environmental Pollution, 2005 , vol. 136, # 2 p. 267 - 273 Title/Abstract Full Text View citing articles Show Details

IC50

4.48

mg/g

In Vitro (others)

Toxic

Ecotoxicology and Enviro...

Title/Abstract Full Text View citing articles Show Details

Regno; Arulgnanendran; Nirmalakhandan

Ecotoxicology and Environmental Safety, 1998 , vol. 39, # 1 p. 48 - 56 Title/Abstract Full Text View citing articles Show Details

IC50

22000

ppm

In Vitro (others)

Toxic

Environmental Toxicology...

Title/Abstract Full Text View citing articles Show Details

Wan, Michael T.; Rahe, James E.

Environmental Toxicology and Chemistry, 1998 , vol. 17, # 10 p. 2041 - 2050 Title/Abstract Full Text View citing articles Show Details

6.92

EC50

0.12

µM

In Vitro (others)

Antiproliferative

Environmental Science an...

Title/Abstract Full Text View citing articles Show Details

Altenburger, Rolf; Walter, Helge; Grote, Matthias

Environmental Science and Technology, 2004 , vol. 38, # 23 p. 6353 - 6362 Title/Abstract Full Text View citing articles Show Details

EC50

Agonist

Hydroxycarboxylic acid receptor 3 [Mus musculus]:Wild

CHOK1

GTPgammaS

Journal of Biological Ch...

Title/Abstract Full Text View citing articles Show Details

Taggart, Andrew K. P.; Kero, Jukka; Gan, Xiaodong; Cai, Tian-Quan; Cheng, Kang; Ippolito, Marc; Ren, Ning; Kaplan, Rebecca; Wu, Kenneth; Wu, Tsuei-Ju; Jin, Lan; Liaw, Chen; Chen, Ruoping; Richman, Jeremy; Connolly, Daniel; Offermanns, Stefan; Wright, Samuel D.; Waters, M. Gerard

Journal of Biological Chemistry, 2005 , vol. 280, # 29 p. 26649 - 26652 Title/Abstract Full Text View citing articles Show Details

EC50

Agonist

Hydroxycarboxylic acid receptor 2 [human]:Wild

CHOK1

GTPgammaS

Journal of Biological Ch...

Title/Abstract Full Text View citing articles Show Details

Journal of Biological Chemistry, 2005 , vol. 280, # 29 p. 26649 - 26652 Title/Abstract Full Text View citing articles Show Details

EC50

Agonist

Hydroxycarboxylic acid receptor 3 [human]:Wild

CHOK1

GTPgammaS

Journal of Biological Ch...

Title/Abstract Full Text View citing articles Show Details

Journal of Biological Chemistry, 2005 , vol. 280, # 29 p. 26649 - 26652 Title/Abstract Full Text View citing articles Show Details

% Inhibition

Antagonist

androgen receptor [human]:Wild

CHOK1

Transactivation assay

Chemical Research in Tox...

Title/Abstract Full Text View citing articles Show Details

Vinggaard, Anne Marie; Niemelae, Jay; Wedebye, Eva Bay; Jensen, Gunde Egeskov

Chemical Research in Toxicology, 2008 , vol. 21, # 4 p. 813 - 823 Title/Abstract Full Text View citing articles Show Details

IC50

44640

mg/L

In Vitro (others)

Toxic

Water Research, 1996 , ...

Title/Abstract Full Text View citing articles Show Details

Prakash; Nirmalakhandan; Sun; Peace

Water Research, 1996 , vol. 30, # 6 p. 1459 - 1463 Title/Abstract Full Text View citing articles Show Details

LC50

380 451

In Vitro (others)

Toxic

Chemosphere, 1999 , vol...

Title/Abstract Full Text View citing articles Show Details

Nalecz-Jawecki, Grzegorz; Sawicki, Jozef

Chemosphere, 1999 , vol. 38, # 14 p. 3211 - 3218 Title/Abstract Full Text View citing articles Show Details

Parameter EC50

Value (qual)

Value (quant) 161 167

Unit

Action on Target

Target

Tissue/Organ

Cell

Bioassay

Dose

Effect

Reference (expand all/collapse all)

In Vitro (others)

Toxic

Chemosphere, 1999 , vol...

Title/Abstract Full Text View citing articles Show Details

In Vitro (others)

Toxic

Environmental Toxicology...

Title/Abstract Full Text View citing articles Show Details

In Vitro (others)

Toxic

Chemosphere, 2001 , vol...

Title/Abstract Full Text View citing articles Show Details

In Vitro (others)

Toxic

Chemosphere, 2001 , vol...

Title/Abstract Full Text View citing articles Show Details

Nalecz-Jawecki, Grzegorz; Sawicki, Jozef

Chemosphere, 1999 , vol. 38, # 14 p. 3211 - 3218 Title/Abstract Full Text View citing articles Show Details

EC50

15900

mg/L

Chung-Yuan, Chen; Ch'i-Feng, Huang

Environmental Toxicology and Chemistry, 1996 , vol. 15, # 9 p. 1464 - 1469 Title/Abstract Full Text View citing articles Show Details

3.76

LC50

10.082

mg/L

Guerra, Roberta

Chemosphere, 2001 , vol. 44, # 8 p. 1737 - 1747 Title/Abstract Full Text View citing articles Show Details

3.75

LC50

10.392

mg/L

Guerra, Roberta

Chemosphere, 2001 , vol. 44, # 8 p. 1737 - 1747 Title/Abstract Full Text View citing articles Show Details

1.07

NOAEC

4900

ppm

In Vitro (others)

330 ppm

Phytotoxic

Archives of Environmenta...

Title/Abstract Full Text View citing articles Show Details

In Vitro (others)

330 ppm

Phytotoxic

Archives of Environmenta...

Title/Abstract Full Text View citing articles Show Details

In Vitro (others)

330 ppm

Phytotoxic

Archives of Environmenta...

Title/Abstract Full Text View citing articles Show Details

In Vitro (others)

330 ppm

Phytotoxic

Archives of Environmenta...

Title/Abstract Full Text View citing articles Show Details

In Vitro (others)

330 ppm

Phytotoxic

Archives of Environmenta...

Title/Abstract Full Text View citing articles Show Details

Okumura; Koyama; Takaku; Satoh

Archives of Environmental Contamination and Toxicology, 2001 , vol. 41, # 2 p. 123 - 128 Title/Abstract Full Text View citing articles Show Details

1.2

NOAEC

3700

ppm

Okumura; Koyama; Takaku; Satoh

Archives of Environmental Contamination and Toxicology, 2001 , vol. 41, # 2 p. 123 - 128 Title/Abstract Full Text View citing articles Show Details

1.4

NOAEC

2300

ppm

Okumura; Koyama; Takaku; Satoh

Archives of Environmental Contamination and Toxicology, 2001 , vol. 41, # 2 p. 123 - 128 Title/Abstract Full Text View citing articles Show Details

1.77

NOAEC

980

ppm

Okumura; Koyama; Takaku; Satoh

Archives of Environmental Contamination and Toxicology, 2001 , vol. 41, # 2 p. 123 - 128 Title/Abstract Full Text View citing articles Show Details

1.8

NOAEC

920

ppm

Okumura; Koyama; Takaku; Satoh

Archives of Environmental Contamination and Toxicology, 2001 , vol. 41, # 2 p. 123 - 128 Title/Abstract Full Text View citing articles Show Details

2.13

NOAEC

430

ppm

In Vitro (others)

330 ppm

Phytotoxic

Archives of Environmenta...

Title/Abstract Full Text View citing articles Show Details

Okumura; Koyama; Takaku; Satoh

Archives of Environmental Contamination and Toxicology, 2001 , vol. 41, # 2 p. 123 - 128 Title/Abstract Full Text View citing articles Show Details

NOAEC

6100

ppm

In Vitro (others)

330 ppm

Phytotoxic

Archives of Environmenta...

Title/Abstract Full Text View citing articles Show Details

Okumura; Koyama; Takaku; Satoh

Archives of Environmental Contamination and Toxicology, 2001 , vol. 41, # 2 p. 123 - 128 Title/Abstract Full Text View citing articles Show Details

1.88

NOAEC

770

ppm

In Vitro (others)

330 ppm

Phytotoxic

Archives of Environmenta...

Title/Abstract Full Text View citing articles Show Details

Okumura; Koyama; Takaku; Satoh

Archives of Environmental Contamination and Toxicology, 2001 , vol. 41, # 2 p. 123 - 128 Title/Abstract Full Text View citing articles Show Details

1.29

EC50

3000

ppm

In Vitro (others)

330 ppm

Phytotoxic

Archives of Environmenta...

Title/Abstract Full Text View citing articles Show Details

Okumura; Koyama; Takaku; Satoh

Archives of Environmental Contamination and Toxicology, 2001 , vol. 41, # 2 p. 123 - 128 Title/Abstract Full Text View citing articles Show Details

EC50

10000

ppm

In Vitro (others)

330 ppm

Phytotoxic

Archives of Environmenta...

Title/Abstract Full Text View citing articles Show Details

Okumura; Koyama; Takaku; Satoh

Archives of Environmental Contamination and Toxicology, 2001 , vol. 41, # 2 p. 123 - 128 Title/Abstract Full Text View citing articles Show Details

EC50

11000

ppm

In Vitro (others)

330 ppm

Phytotoxic

Archives of Environmenta...

Title/Abstract Full Text View citing articles Show Details

Okumura; Koyama; Takaku; Satoh

Archives of Environmental Contamination and Toxicology, 2001 , vol. 41, # 2 p. 123 - 128 Title/Abstract Full Text View citing articles Show Details

EC50

7000

ppm

In Vitro (others)

330 ppm

Phytotoxic

Archives of Environmenta...

Title/Abstract Full Text View citing articles Show Details

Okumura; Koyama; Takaku; Satoh

Archives of Environmental Contamination and Toxicology, 2001 , vol. 41, # 2 p. 123 - 128 Title/Abstract Full Text View citing articles Show Details

1.16

EC50

4000

ppm

In Vitro (others)

330 ppm

Phytotoxic

Archives of Environmenta...

Title/Abstract Full Text View citing articles Show Details

Okumura; Koyama; Takaku; Satoh

Archives of Environmental Contamination and Toxicology, 2001 , vol. 41, # 2 p. 123 - 128 Title/Abstract Full Text View citing articles Show Details

1.16

EC50

4000

ppm

In Vitro (others)

330 ppm

Phytotoxic

Archives of Environmenta...

Title/Abstract Full Text View citing articles Show Details

Okumura; Koyama; Takaku; Satoh

Archives of Environmental Contamination and Toxicology, 2001 , vol. 41, # 2 p. 123 - 128

Title/Abstract Full Text View citing articles Show Details

1.38

EC50

2400

ppm

In Vitro (others)

330 ppm

Phytotoxic

Archives of Environmenta...

Title/Abstract Full Text View citing articles Show Details

Okumura; Koyama; Takaku; Satoh

Archives of Environmental Contamination and Toxicology, 2001 , vol. 41, # 2 p. 123 - 128 Title/Abstract Full Text View citing articles Show Details

EC50

13000

ppm

In Vitro (others)

330 ppm

Phytotoxic

Archives of Environmenta...

Title/Abstract Full Text View citing articles Show Details

Okumura; Koyama; Takaku; Satoh

Archives of Environmental Contamination and Toxicology, 2001 , vol. 41, # 2 p. 123 - 128 Title/Abstract Full Text View citing articles Show Details

1.42

NOAEC

2200

ppm

In Vitro (others)

330 ppm

Phytotoxic

Archives of Environmenta...

Title/Abstract Full Text View citing articles Show Details

Okumura; Koyama; Takaku; Satoh

Archives of Environmental Contamination and Toxicology, 2001 , vol. 41, # 2 p. 123 - 128 Title/Abstract Full Text View citing articles Show Details

1.16

EC50

4000

ppm

In Vitro (others)

330 ppm

Phytotoxic

Archives of Environmenta...

Title/Abstract Full Text View citing articles Show Details

Okumura; Koyama; Takaku; Satoh

Archives of Environmental Contamination and Toxicology, 2001 , vol. 41, # 2 p. 123 - 128 Title/Abstract Full Text View citing articles Show Details

EC50

13700 20100

ppm

In Vitro (others)

Toxic

Water Research, 2001 , ...

Title/Abstract Full Text View citing articles Show Details

Jennings, Victor L. K.; Rayner-Brandes, Michael H.; Bird, David J.

Water Research, 2001 , vol. 35, # 14 p. 3448 - 3456 Title/Abstract Full Text View citing articles Show Details

IC50

136019 282283

µM

In Vitro (others)

Toxic

Ecotoxicology and Enviro...

Title/Abstract Full Text View citing articles Show Details

Bogaerts; Bohatier; Bonnemoy

Ecotoxicology and Environmental Safety, 2001 , vol. 49, # 3 p. 293 - 301 Title/Abstract Full Text View citing articles Show Details

IC50

enzyme:Wild

In Vitro (others)

Chemosphere, 2008 , vol...

Title/Abstract Full Text View citing articles Show Details

Farnet; Gil; Ferre

Chemosphere, 2008 , vol. 70, # 5 p. 895 - 900 Title/Abstract Full Text View citing articles Show Details

IC50

enzyme:Wild

In Vitro (others)

Chemosphere, 2008 , vol...

Title/Abstract Full Text View citing articles Show Details

Farnet; Gil; Ferre

Chemosphere, 2008 , vol. 70, # 5 p. 895 - 900 Title/Abstract Full Text View citing articles Show Details

EC50

254000

µM

In Vitro (others)

Antimicrobial

Ecotoxicology and Enviro...

Title/Abstract Full Text Show Details

In Vitro (others)

Developmental

Archives of Environmenta...

Title/Abstract Full Text View citing articles Show Details

Chen; Hee

Ecotoxicology and Environmental Safety, 1995 , vol. 30, # 2 p. 120 - 123 Title/Abstract Full Text Show Details

LC50

6.78

g/L

Rayburn; Fisher

Archives of Environmental Contamination and Toxicology, 1997 , vol. 33, # 2 p. 217 - 221 Title/Abstract Full Text View citing articles Show Details

LC50

6.94

g/L

In Vitro (others)

Developmental

Archives of Environmenta...

Title/Abstract Full Text View citing articles Show Details

Rayburn; Fisher

Archives of Environmental Contamination and Toxicology, 1997 , vol. 33, # 2 p. 217 - 221 Title/Abstract Full Text View citing articles Show Details

IC50

20000 28000

ppm

In Vitro (others)

Antifungal

Environmental Toxicology...

Title/Abstract Full Text View citing articles Show Details

Wan, Michael T.; Rahe, James E.; Watts, Ronald G.

Environmental Toxicology and Chemistry, 1998 , vol. 17, # 7 p. 1421 - 1428 Title/Abstract Full Text View citing articles Show Details

IC50

48000

mg/L

In Vitro (others)

Toxic

Water Research, 1994 , ...

Title/Abstract Full Text Show Details

In Vitro (others)

Toxic

Chemosphere, 2000 , vol...

Title/Abstract Full Text View citing articles Show Details

Nirmalakhandan; Arulgnanendran; Mohsin; Sun; Cadena

Water Research, 1994 , vol. 28, # 3 p. 543 - 551 Title/Abstract Full Text Show Details

EC50

2.162 2.164

Cassells; Lane; Depala; Saeed; Craston

Chemosphere, 2000 , vol. 40, # 6 p. 609 - 618 Title/Abstract Full Text View citing articles Show Details

2.57

NOAEC

157

mg/L

In Vitro (others)

Toxic

Environmental Toxicology...

Title/Abstract Full Text View citing articles Show Details

Andersen; Wollenberger; Halling-Sorensen; Kusk

Environmental Toxicology and Chemistry, 2001 , vol. 20, # 12 p. 2821 - 2829 Title/Abstract Full Text View citing articles Show Details

LC10

390

mg/L

In Vitro (others)

Toxic

Environmental Toxicology...

Title/Abstract Full Text View citing articles Show Details

Andersen; Wollenberger; Halling-Sorensen; Kusk

Environmental Toxicology and Chemistry, 2001 , vol. 20, # 12 p. 2821 - 2829 Title/Abstract Full Text View citing articles Show Details

LC50

35001

mg/L

In Vitro (others)

Toxic

Environmental Toxicology...

Title/Abstract Full Text View citing articles Show Details

Andersen; Wollenberger; Halling-Sorensen; Kusk

Environmental Toxicology and Chemistry, 2001 , vol. 20, # 12 p. 2821 - 2829 Title/Abstract Full Text View citing articles Show Details

1.04

EC50

5276.1

mg/L

In Vitro (others)

Antialgae

Environmental Toxicology...

Title/Abstract Full Text View citing articles Show Details

Tsai, Kuo-Pei; Chen, Chung-Yuan

Environmental Toxicology and Chemistry, 2007 , vol. 26, # 9 p. 1931 - 1939 Title/Abstract Full Text View citing articles Show Details

pIC50

-0.04

Inhibitor

Hansch; Anderson

Journal of medicinal chemistry, 1967 , vol. 10, # 5 p. 745 - 753 Title/Abstract Full Text Show Details

Journal of medicinal che...

Title/Abstract Full Text Show Details

pIC50

0.54

Journal of medicinal che...

Title/Abstract Full Text Show Details

muscle cell

Journal of medicinal che...

Title/Abstract Full Text Show Details

peritoneal macrophage

Bioorganic and Medicinal...

Title/Abstract Full Text View citing articles Show Details

Leo; Hansch; Church

Journal of medicinal chemistry, 1969 , vol. 12, # 5 p. 766 - 771 Title/Abstract Full Text Show Details

pIC50

0.4

Hansch; Anderson

Journal of medicinal chemistry, 1967 , vol. 10, # 5 p. 745 - 753 Title/Abstract Full Text Show Details

IC50

7.3

µg/mL

Inhibitor

Matsuda, Hisashi; Ando, Shin; Morikawa, Toshio; Kataoka, Shinya; Yoshikawa, Masayuki

Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 7 p. 1949 - 1953 Title/Abstract Full Text View citing articles Show Details

Ratio

Journal of medicinal che...

Title/Abstract Full Text Show Details

carbonyl reductase (NADPH) [Rhodococcus erythropolis]:Wild

Bioorganic and medicinal...

Title/Abstract Full Text Show Details

carbonyl reductase (NADPH) [Rhodococcus erythropolis]:Wild

Bioorganic and medicinal...

Title/Abstract Full Text Show Details

Journal of medicinal che...

Title/Abstract Full Text Show Details

Neutrophil elastase [human]:Wild

Biological and Pharmaceu...

Title/Abstract Full Text View citing articles Show Details

Segal; Katz; Van Duuren

Journal of medicinal chemistry, 1971 , vol. 14, # 12 p. 1152 - 1154 Title/Abstract Full Text Show Details

Vmax

3.5

U/mg

Radioligand (/ligand)

Zelinski; Kula

Bioorganic and medicinal chemistry, 1994 , vol. 2, # 6 p. 421 - 428 Title/Abstract Full Text Show Details

330

Inhibitor

Zelinski; Kula

Bioorganic and medicinal chemistry, 1994 , vol. 2, # 6 p. 421 - 428 Title/Abstract Full Text Show Details

Number

Segal; Katz; Van Duuren

Journal of medicinal chemistry, 1971 , vol. 14, # 12 p. 1152 - 1154 Title/Abstract Full Text Show Details

4.13

EC50

4.3

µg/mL

Beyer, Gaby; Melzig, Matthias F.

Biological and Pharmaceutical Bulletin, 2005 , vol. 28, # 7 p. 1183 - 1186 Title/Abstract Full Text View citing articles Show Details

pIC50

0.54

Journal of Medicinal Che...

Title/Abstract Full Text Show Details

Journal of Medicinal Che...

Title/Abstract Full Text Show Details

Kier; Murray; Hall

Journal of Medicinal Chemistry, 1975 , vol. 18, # 12 p. 1272 - 1274 Title/Abstract Full Text Show Details

0.1

Inhibitor

Succinate Oxidase [taurine cattle]:Wild

Kier; Murray; Hall

Journal of Medicinal Chemistry, 1975 , vol. 18, # 12 p. 1272 - 1274 Title/Abstract Full Text Show Details

EC50

Free fatty acid receptor 3 [Rattus norvegicus]:Wild

Patent: US2003/113810 ...

Title/Abstract Full Text Show Details

Radioligand (/ligand)

hydroxynitrilase [Hevea brasiliensis]:Wild

Journal of Medicinal Che...

Title/Abstract Full Text View citing articles Show Details

Wise, Alan; Brown, Andrew James

Patent: US2003/113810 A1, 2003 ; Title/Abstract Full Text Show Details

1.52

30000

µM

Cozzini, Pietro; Fornabaio, Micaela; Marabotti, Anna; Abraham, Donald J.; Kellogg, Glen E.; Mozzarelli, Andrea

Journal of Medicinal Chemistry, 2002 , vol. 45, # 12 p. 2469 - 2483 Title/Abstract Full Text View citing articles Show Details

Journal of Natural Produ...

Title/Abstract Full Text View citing articles Show Details

Sun, Peng; Meng, Li-Yuan; Tang, Hua; Liu, Bao-Shu; Li, Ling; Yi, Yanghua; Zhang, Wen

Journal of Natural Products, 2012 , vol. 75, # 9 p. 1656 - 1659 Title/Abstract Full Text View citing articles Show Details

Journal of Natural Produ...

Title/Abstract Full Text View citing articles Show Details

Sun, Peng; Meng, Li-Yuan; Tang, Hua; Liu, Bao-Shu; Li, Ling; Yi, Yanghua; Zhang, Wen

Journal of Natural Products, 2012 , vol. 75, # 9 p. 1656 - 1659 Title/Abstract Full Text View citing articles Show Details

Journal of Natural Produ...

Title/Abstract Full Text View citing articles Show Details

Sun, Peng; Meng, Li-Yuan; Tang, Hua; Liu, Bao-Shu; Li, Ling; Yi, Yanghua; Zhang, Wen

Journal of Natural Products, 2012 , vol. 75, # 9 p. 1656 - 1659 Title/Abstract Full Text View citing articles Show Details

Journal of Natural Produ...

Title/Abstract Full Text View citing articles Show Details

Sun, Peng; Meng, Li-Yuan; Tang, Hua; Liu, Bao-Shu; Li, Ling; Yi, Yanghua; Zhang, Wen

Journal of Natural Products, 2012 , vol. 75, # 9 p. 1656 - 1659 Title/Abstract Full Text View citing articles Show Details

Journal of Natural Produ...

Title/Abstract Full Text View citing articles Show Details

Sun, Peng; Meng, Li-Yuan; Tang, Hua; Liu, Bao-Shu; Li, Ling; Yi, Yanghua; Zhang, Wen

Journal of Natural Products, 2012 , vol. 75, # 9 p. 1656 - 1659 Title/Abstract Full Text View citing articles Show Details

MIC

58.5

µg/mL

Biological and Pharmaceu...

Title/Abstract Full Text View citing articles Show Details

McGaw, Lyndy Joy; Lall, Namrita; Hlokwe, Tiny Motlatso; Michel, Anita Luise; Meyer, Jacobus Johannes Marion; Eloff, Jacobus Nicolaas

Biological and Pharmaceutical Bulletin, 2008 , vol. 31, # 7 p. 1429 - 1433 Title/Abstract Full Text View citing articles Show Details

1.97

MBC

625

µg/mL

Biological and Pharmaceu...

Title/Abstract Full Text View citing articles Show Details

McGaw, Lyndy Joy; Lall, Namrita; Hlokwe, Tiny Motlatso; Michel, Anita Luise; Meyer, Jacobus Johannes Marion; Eloff, Jacobus Nicolaas

Biological and Pharmaceutical Bulletin, 2008 , vol. 31, # 7 p. 1429 - 1433 Title/Abstract Full Text View citing articles Show Details

3.35

MIC

26.01

µg/mL

Biological and Pharmaceu...

Title/Abstract Full Text View citing articles Show Details

McGaw, Lyndy Joy; Lall, Namrita; Hlokwe, Tiny Motlatso; Michel, Anita Luise; Meyer, Jacobus Johannes Marion; Eloff, Jacobus Nicolaas

Biological and Pharmaceutical Bulletin, 2008 , vol. 31, # 7 p. 1429 - 1433 Title/Abstract Full Text View citing articles Show Details

1.37

MBC

2500

µg/mL

Biological and Pharmaceu...

Title/Abstract Full Text View citing articles Show Details

McGaw, Lyndy Joy; Lall, Namrita; Hlokwe, Tiny Motlatso; Michel, Anita Luise; Meyer, Jacobus Johannes Marion; Eloff, Jacobus Nicolaas

Biological and Pharmaceutical Bulletin, 2008 , vol. 31, # 7 p. 1429 - 1433 Title/Abstract Full Text View citing articles Show Details

2.09

MIC

468.63

µg/mL

Biological and Pharmaceu...

Title/Abstract Full Text View citing articles Show Details

McGaw, Lyndy Joy; Lall, Namrita; Hlokwe, Tiny Motlatso; Michel, Anita Luise; Meyer, Jacobus Johannes Marion; Eloff, Jacobus Nicolaas

Biological and Pharmaceutical Bulletin, 2008 , vol. 31, # 7 p. 1429 - 1433 Title/Abstract Full Text View citing articles Show Details

4.01

MIC

5.7

µg/mL

Biological and Pharmaceu...

Title/Abstract Full Text View citing articles Show Details

McGaw, Lyndy Joy; Lall, Namrita; Hlokwe, Tiny Motlatso; Michel, Anita Luise; Meyer, Jacobus Johannes Marion; Eloff, Jacobus Nicolaas

Biological and Pharmaceutical Bulletin, 2008 , vol. 31, # 7 p. 1429 - 1433 Title/Abstract Full Text View citing articles Show Details

MBC

2500

µg/mL

Biological and Pharmaceu...

Title/Abstract Full Text View citing articles Show Details

McGaw, Lyndy Joy; Lall, Namrita; Hlokwe, Tiny Motlatso; Michel, Anita Luise; Meyer, Jacobus Johannes Marion; Eloff, Jacobus Nicolaas

Biological and Pharmaceutical Bulletin, 2008 , vol. 31, # 7 p. 1429 - 1433 Title/Abstract Full Text View citing articles Show Details

2.66

MIC

126.75

µg/mL

Biological and Pharmaceu...

Title/Abstract Full Text View citing articles Show Details

McGaw, Lyndy Joy; Lall, Namrita; Hlokwe, Tiny Motlatso; Michel, Anita Luise; Meyer, Jacobus Johannes Marion; Eloff, Jacobus Nicolaas

Biological and Pharmaceutical Bulletin, 2008 , vol. 31, # 7 p. 1429 - 1433 Title/Abstract Full Text View citing articles Show Details

2.35

MIC

260.38

µg/mL

Biological and Pharmaceu...

Title/Abstract Full Text View citing articles Show Details

McGaw, Lyndy Joy; Lall, Namrita; Hlokwe, Tiny Motlatso; Michel, Anita Luise; Meyer, Jacobus Johannes Marion; Eloff, Jacobus Nicolaas

Biological and Pharmaceutical Bulletin, 2008 , vol. 31, # 7 p. 1429 - 1433 Title/Abstract Full Text View citing articles Show Details

2.06

MIC

500

µg/mL

Biological and Pharmaceu...

Title/Abstract Full Text View citing articles Show Details

McGaw, Lyndy Joy; Lall, Namrita; Hlokwe, Tiny Motlatso; Michel, Anita Luise; Meyer, Jacobus Johannes Marion; Eloff, Jacobus Nicolaas

Biological and Pharmaceutical Bulletin, 2008 , vol. 31, # 7 p. 1429 - 1433 Title/Abstract Full Text View citing articles Show Details

MBC

2500

µg/mL

Biological and Pharmaceu...

Title/Abstract Full Text View citing articles Show Details

McGaw, Lyndy Joy; Lall, Namrita; Hlokwe, Tiny Motlatso; Michel, Anita Luise; Meyer, Jacobus Johannes Marion; Eloff, Jacobus Nicolaas

Biological and Pharmaceutical Bulletin, 2008 , vol. 31, # 7 p. 1429 - 1433 Title/Abstract Full Text View citing articles Show Details

1.67

MBC

1250

µg/mL

Biological and Pharmaceu...

Title/Abstract Full Text View citing articles Show Details

McGaw, Lyndy Joy; Lall, Namrita; Hlokwe, Tiny Motlatso; Michel, Anita Luise; Meyer, Jacobus Johannes Marion; Eloff, Jacobus Nicolaas

Biological and Pharmaceutical Bulletin, 2008 , vol. 31, # 7 p. 1429 - 1433 Title/Abstract Full Text View citing articles Show Details

2.09

MIC

469

µg/mL

Biological and Pharmaceu...

Title/Abstract Full Text View citing articles Show Details

McGaw, Lyndy Joy; Lall, Namrita; Hlokwe, Tiny Motlatso; Michel, Anita Luise; Meyer, Jacobus Johannes Marion; Eloff, Jacobus Nicolaas

Biological and Pharmaceutical Bulletin, 2008 , vol. 31, # 7 p. 1429 - 1433 Title/Abstract Full Text View citing articles Show Details

1.97

MBC

625

µg/mL

Biological and Pharmaceu...

Title/Abstract Full Text View citing articles Show Details

McGaw, Lyndy Joy; Lall, Namrita; Hlokwe, Tiny Motlatso; Michel, Anita Luise; Meyer, Jacobus Johannes Marion; Eloff, Jacobus Nicolaas

Biological and Pharmaceutical Bulletin, 2008 , vol. 31, # 7 p. 1429 - 1433 Title/Abstract Full Text View citing articles Show Details

MBC

2500

µg/mL

Biological and Pharmaceu...

Title/Abstract Full Text View citing articles Show Details

McGaw, Lyndy Joy; Lall, Namrita; Hlokwe, Tiny Motlatso; Michel, Anita Luise; Meyer, Jacobus Johannes Marion; Eloff, Jacobus Nicolaas

Biological and Pharmaceutical Bulletin, 2008 , vol. 31, # 7 p. 1429 - 1433 Title/Abstract Full Text View citing articles Show Details

MBC

2500

µg/mL

Biological and Pharmaceu...

Title/Abstract Full Text View citing articles Show Details

McGaw, Lyndy Joy; Lall, Namrita; Hlokwe, Tiny Motlatso; Michel, Anita Luise; Meyer, Jacobus Johannes Marion; Eloff, Jacobus Nicolaas

Biological and Pharmaceutical Bulletin, 2008 , vol. 31, # 7 p. 1429 - 1433 Title/Abstract Full Text View citing articles Show Details

1.97

MIC

625

µg/mL

Biological and Pharmaceu...

Title/Abstract Full Text View citing articles Show Details

McGaw, Lyndy Joy; Lall, Namrita; Hlokwe, Tiny Motlatso; Michel, Anita Luise; Meyer, Jacobus Johannes Marion; Eloff, Jacobus Nicolaas

Biological and Pharmaceutical Bulletin, 2008 , vol. 31, # 7 p. 1429 - 1433 Title/Abstract Full Text View citing articles Show Details

Activity

299

1,3-Butanediol Dehydrogenase [Candida parapsilosis]:Wild

Bioscience, biotechnolog...

Title/Abstract Full Text View citing articles Show Details

Yamamoto; Matsuyama; Kobayashi; Kawada

Bioscience, biotechnology, and biochemistry, 1995 , vol. 59, # 9 p. 1769 - 1770 Title/Abstract Full Text View citing articles Show Details

Activity

acetoin dehydrogenase [Enterobacter aerogenes]:Wild

European Journal of Bioc...

Title/Abstract Full Text Show Details

Journal of Medicinal Che...

Title/Abstract Full Text Show Details

Chemical reviews, 1989 ,...

Title/Abstract Full Text Show Details

Chemical reviews, 1989 ,...

Title/Abstract Full Text Show Details

Carballo; Martin; Bernardo; Gonzalez

European Journal of Biochemistry, 1991 , vol. 198, # 2 p. 327 - 332 Title/Abstract Full Text Show Details

Activity

Jurs; Chou; Yuan

Journal of Medicinal Chemistry, 1979 , vol. 22, # 5 p. 476 - 483 Title/Abstract Full Text Show Details

pIC50

0.49

S.P.Gupta

Chemical reviews, 1989 , vol. 89, # 8 p. 1765 - 1800 Title/Abstract Full Text Show Details

pIC50

0.65

S.P.Gupta

Chemical reviews, 1989 , vol. 89, # 8 p. 1765 - 1800

Title/Abstract Full Text Show Details

pIC50

0.4

Bioorganic and Medicinal...

Title/Abstract Full Text View citing articles Show Details

Verma, Rajeshwar P.; Kurup, Alka; Hansch, Corwin

Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 1 p. 237 - 255 Title/Abstract Full Text View citing articles Show Details

pIC50

0.49

Bioorganic and Medicinal...

Title/Abstract Full Text View citing articles Show Details

Jaiswal, Mona; Khadikar, Padmakar

Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 7 p. 1731 - 1736 Title/Abstract Full Text View citing articles Show Details

Activity

99.1

monocyte

British Journal of Derma...

Title/Abstract Full Text View citing articles Show Details

Mrowietz; Jessat; Schwarz

British Journal of Dermatology, 1997 , vol. 136, # 4 p. 542 - 547 Title/Abstract Full Text View citing articles Show Details

Activity

Glycerol Dehydrogenase (NADP+) [Aspergillus nidulans]:Wild

Journal of General Micro...

Title/Abstract Full Text View citing articles Show Details

Schuurink; Busink; Hondmann; Witteveen; Visser

Journal of General Microbiology, 1990 , vol. 136, # 6 p. 1043 - 1050 Title/Abstract Full Text View citing articles Show Details

Activity

110.6

D10(N4)M

British Journal of Derma...

Title/Abstract Full Text View citing articles Show Details

Mrowietz; Jessat; Schwarz

British Journal of Dermatology, 1997 , vol. 136, # 4 p. 542 - 547 Title/Abstract Full Text View citing articles Show Details

Activity

Glycerol Dehydrogenase (NADP+) [Aspergillus niger]:Wild

Journal of General Micro...

Title/Abstract Full Text View citing articles Show Details

Schuurink; Busink; Hondmann; Witteveen; Visser

Journal of General Microbiology, 1990 , vol. 136, # 6 p. 1043 - 1050 Title/Abstract Full Text View citing articles Show Details

Activity

103.5

British Journal of Derma...

Title/Abstract Full Text View citing articles Show Details

Mrowietz; Jessat; Schwarz

British Journal of Dermatology, 1997 , vol. 136, # 4 p. 542 - 547 Title/Abstract Full Text View citing articles Show Details

Activity

106.9

monocyte

British Journal of Derma...

Title/Abstract Full Text View citing articles Show Details

Mrowietz; Jessat; Schwarz

British Journal of Dermatology, 1997 , vol. 136, # 4 p. 542 - 547 Title/Abstract Full Text View citing articles Show Details

Activity

107.1

monocyte

British Journal of Derma...

Title/Abstract Full Text View citing articles Show Details

Mrowietz; Jessat; Schwarz

British Journal of Dermatology, 1997 , vol. 136, # 4 p. 542 - 547 Title/Abstract Full Text View citing articles Show Details

Cytochrome P450 2E1:Wild

Current Medicinal Chemis...

Title/Abstract Full Text View citing articles Show Details

Lewis, David F.V.

Current Medicinal Chemistry, 2003 , vol. 10, # 19 p. 1955 - 1972 Title/Abstract Full Text View citing articles Show Details

Cytochrome P450 2E1 [human]:Wild

Current Medicinal Chemis...

Title/Abstract Full Text View citing articles Show Details

Lewis, David F.V.

Current Medicinal Chemistry, 2003 , vol. 10, # 19 p. 1955 - 1972 Title/Abstract Full Text View citing articles Show Details

Cytochrome P450 2E1 [human]:Wild

Current Medicinal Chemis...

Title/Abstract Full Text View citing articles Show Details

Lewis, David F.V.

Current Medicinal Chemistry, 2003 , vol. 10, # 19 p. 1955 - 1972 Title/Abstract Full Text View citing articles Show Details

Activity

Alcohol Dehydrogenase 6 (Class V) [Saccharomyces cerevisiae]:Wild

Biochemical Journal, 200...

Title/Abstract Full Text View citing articles Show Details

Larroy, Carol; Fernandez, M. Rosario; Gonzalez, Eva; Pares, Xavier; Biosca, Josep A.

Biochemical Journal, 2002 , vol. 361, # 1 p. 163 - 172 Title/Abstract Full Text View citing articles Show Details

0.1

Antimicrobial

Proceedings of the Natio...

Title/Abstract Full Text View citing articles Show Details

Niu, Qiuhong; Huang, Xiaowei; Zhang, Lin; Xu, Jianping; Yang, Dongmei; Wei, Kangbi; Niu, Xuemei; An, Zhiqiang; Bennett, Joan Wennstrom; Zou, Chenggang; Yang, Jinkui; Zhang, Ke-Qin

Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 38 p. 16631 - 16636 Title/Abstract Full Text View citing articles Show Details

0.2

Antimicrobial

Proceedings of the Natio...

Title/Abstract Full Text View citing articles Show Details

Niu, Qiuhong; Huang, Xiaowei; Zhang, Lin; Xu, Jianping; Yang, Dongmei; Wei, Kangbi; Niu, Xuemei; An, Zhiqiang; Bennett, Joan Wennstrom; Zou, Chenggang; Yang, Jinkui; Zhang, Ke-Qin

Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 38 p. 16631 - 16636 Title/Abstract Full Text View citing articles Show Details

3.82

IC50

150

µM

Cytochrome P450 2E1 [human]:Wild

European Journal of Phar...

Title/Abstract Full Text View citing articles Show Details

Martikainen, Laura E.; Rahnasto-Rilla, Minna; Neshybova, Silvie; Lahtela-Kakkonen, Maija; Raunio, Hannu; Juvonen, Risto O.

European Journal of Pharmaceutical Sciences, 2012 , vol. 47, # 5 p. 996 - 1005 Title/Abstract Full Text View citing articles Show Details

EC50

Proceedings of the Natio...

Title/Abstract Full Text View citing articles Show Details

Niu, Qiuhong; Huang, Xiaowei; Zhang, Lin; Xu, Jianping; Yang, Dongmei; Wei, Kangbi; Niu, Xuemei; An, Zhiqiang; Bennett, Joan Wennstrom; Zou, Chenggang; Yang, Jinkui; Zhang, Ke-Qin

Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 38 p. 16631 - 16636 Title/Abstract Full Text View citing articles Show Details

% Inhibition

European Journal of Medi...

Title/Abstract Full Text View citing articles Show Details

Xu, Hui; Fan, Ling-Ling

European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 364 - 369 Title/Abstract Full Text View citing articles Show Details

% Inhibition

European Journal of Medi...

Title/Abstract Full Text View citing articles Show Details

Xu, Hui; Fan, Ling-Ling

European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 364 - 369 Title/Abstract Full Text View citing articles Show Details

% Inhibition

European Journal of Medi...

Title/Abstract Full Text View citing articles Show Details

Xu, Hui; Fan, Ling-Ling

European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 364 - 369 Title/Abstract Full Text View citing articles Show Details

% Inhibition

European Journal of Medi...

Title/Abstract Full Text View citing articles Show Details

Xu, Hui; Fan, Ling-Ling

European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 364 - 369 Title/Abstract Full Text View citing articles Show Details

% Inhibition

European Journal of Medi...

Title/Abstract Full Text View citing articles Show Details

Xu, Hui; Fan, Ling-Ling

European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 364 - 369 Title/Abstract Full Text View citing articles Show Details

2.81

IC50

µg/mL

Inhibitor

Glucosyltransferase [Streptococcus pneumoniae]:Wild

Patent: WO2001/1944 A1...

Title/Abstract Full Text Show Details

Inhibitor

Glucosyltransferase [Streptococcus pneumoniae]:Wild

Patent: WO2001/1944 A1...

Title/Abstract Full Text Show Details

Inhibitor

Glucosyltransferase [Streptococcus pneumoniae]:Wild

Patent: WO2001/1944 A1...

Title/Abstract Full Text Show Details

Inhibitor

Glucosyltransferase [Streptococcus pneumoniae]:Wild

Patent: WO2001/1944 A1...

Title/Abstract Full Text Show Details

Antifungal

Journal of Natural Produ...

Title/Abstract Full Text View citing articles Show Details

LOTTE CONFECTIONERY CO., LTD.

Patent: WO2001/1944 A1, 2001 ; Title/Abstract Full Text Show Details

µg/mL

LOTTE CONFECTIONERY CO., LTD.

Patent: WO2001/1944 A1, 2001 ; Title/Abstract Full Text Show Details

2.86

IC50

µg/mL

LOTTE CONFECTIONERY CO., LTD.

Patent: WO2001/1944 A1, 2001 ; Title/Abstract Full Text Show Details

2.76

IC50

100

µg/mL

LOTTE CONFECTIONERY CO., LTD.

Patent: WO2001/1944 A1, 2001 ; Title/Abstract Full Text Show Details

Siddiqui, Imran Nafees; Zahoor, Aqib; Hussain, Hidayat; Ahmed, Ishtiaq; Ahmad, Viqar Uddin; Padula, Daniele; Draeger, Siegfried; Schulz, Barbara; Meier, Kathrin; Steinert, Michael; Kurtan, Tibor; Floerke, Ulrich; Pescitelli, Gennaro; Krohn, Karsten

Journal of Natural Products, 2011 , vol. 74, # 3 p. 365 - 373 Title/Abstract Full Text View citing articles Show Details

Antimicrobial

Journal of Medicinal Che...

Title/Abstract Full Text View citing articles Show Details

Hussain, Hidayat; Specht, Sabine; Sarite, Salem R.; Saeftel, Michael; Hoerauf, Achim; Schulz, Barbara; Krohn, Karsten

Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4913 - 4917 Title/Abstract Full Text View citing articles Show Details

pEC50

-2.44

Antimicrobial

Pharmaceutical Chemistry...

Title/Abstract Full Text View citing articles Show Details

Grigor'ev; Raevskii

Pharmaceutical Chemistry Journal, 2011 , vol. 45, # 7 p. 406 - 411 Title/Abstract Full Text View citing articles Show Details

Antifungal

Journal of Medicinal Che...

Title/Abstract Full Text View citing articles Show Details

Hussain, Hidayat; Specht, Sabine; Sarite, Salem R.; Saeftel, Michael; Hoerauf, Achim; Schulz, Barbara; Krohn, Karsten

Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4913 - 4917 Title/Abstract Full Text View citing articles Show Details

Antimicrobial

Journal of Medicinal Che...

Title/Abstract Full Text View citing articles Show Details

Hussain, Hidayat; Specht, Sabine; Sarite, Salem R.; Saeftel, Michael; Hoerauf, Achim; Schulz, Barbara; Krohn, Karsten

Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4913 - 4917 Title/Abstract Full Text View citing articles Show Details

Journal of Medicinal Che...

Title/Abstract Full Text View citing articles Show Details

Hussain, Hidayat; Specht, Sabine; Sarite, Salem R.; Saeftel, Michael; Hoerauf, Achim; Schulz, Barbara; Krohn, Karsten

Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4913 - 4917 Title/Abstract Full Text View citing articles Show Details

pGI50

-2.15

Antiprotozoal

Pharmaceutical Chemistry...

Title/Abstract Full Text View citing articles Show Details

Grigor'ev; Raevskii

Pharmaceutical Chemistry Journal, 2011 , vol. 45, # 7 p. 406 - 411 Title/Abstract Full Text View citing articles Show Details

3.5

IC50

313.8

µM

Inhibitor

Mif Tautomerase:Wild

Current Medicinal Chemis...

Title/Abstract Full Text View citing articles Show Details

Garai, Janos; Lorand, Tamas

Current Medicinal Chemistry, 2009 , vol. 16, # 9 p. 1091 - 1114 Title/Abstract Full Text View citing articles Show Details

Antifungal

European Journal of Medi...

Title/Abstract Full Text View citing articles Show Details

Sahu, Pramod K.; Sahu, Praveen K.; Gupta; Thavaselvam; Agarwal

European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 366 - 378 Title/Abstract Full Text View citing articles Show Details

Antifungal

European Journal of Medi...

Title/Abstract Full Text View citing articles Show Details

Sahu, Pramod K.; Sahu, Praveen K.; Gupta; Thavaselvam; Agarwal

European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 366 - 378 Title/Abstract Full Text View citing articles Show Details

Antifungal

European Journal of Medi...

Title/Abstract Full Text View citing articles Show Details

Sahu, Pramod K.; Sahu, Praveen K.; Gupta; Thavaselvam; Agarwal

European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 366 - 378 Title/Abstract Full Text View citing articles Show Details

EC50

Hydroxycarboxylic acid receptor 3 [human]:Wild

Trends in Pharmacologica...

Title/Abstract Full Text View citing articles Show Details

Offermanns, Stefan

Trends in Pharmacological Sciences, 2006 , vol. 27, # 7 p. 384 - 390 Title/Abstract Full Text View citing articles Show Details

EC50

Hydroxycarboxylic acid receptor 1:Wild

Trends in Pharmacologica...

Title/Abstract Full Text View citing articles Show Details

Offermanns, Stefan

Trends in Pharmacological Sciences, 2006 , vol. 27, # 7 p. 384 - 390 Title/Abstract Full Text View citing articles Show Details

EC50

Hydroxycarboxylic acid receptor 2:Wild

Trends in Pharmacologica...

Title/Abstract Full Text View citing articles Show Details

Offermanns, Stefan

Trends in Pharmacological Sciences, 2006 , vol. 27, # 7 p. 384 - 390 Title/Abstract Full Text View citing articles Show Details

% Inhibition

lipase [Bacillus subtilis]:Wild

Enzymology inhibition

10 %_(v/v)

Process Biochemistry, 20...

Title/Abstract Full Text View citing articles Show Details

Emtenani, Shirin; Asoodeh, Ahmad; Emtenani, Shamsi

Process Biochemistry, 2013 , vol. 48, # 11 p. 1679 - 1685 Title/Abstract Full Text View citing articles Show Details

% Inhibition

lipase [Bacillus subtilis]:Wild

Enzymology inhibition

20 %_(v/v)

Process Biochemistry, 20...

Title/Abstract Full Text View citing articles Show Details

Emtenani, Shirin; Asoodeh, Ahmad; Emtenani, Shamsi

Process Biochemistry, 2013 , vol. 48, # 11 p. 1679 - 1685 Title/Abstract Full Text View citing articles Show Details

Area Of Sterile Zone

mm2

Antibiotic

Pharmaceutical Chemistry...

Title/Abstract Full Text View citing articles Show Details

Ovsyannikova; Vol'Eva; Belostotskaya; Komissarova; Malkova; Kurkovskaya

Pharmaceutical Chemistry Journal, 2013 , vol. 47, # 3 p. 142 - 145 Title/Abstract Full Text View citing articles Show Details

Area Of Sterile Zone

Antibiotic

Pharmaceutical Chemistry...

Title/Abstract Full Text View citing articles Show Details

Ovsyannikova; Vol'Eva; Belostotskaya; Komissarova; Malkova; Kurkovskaya

Pharmaceutical Chemistry Journal, 2013 , vol. 47, # 3 p. 142 - 145 Title/Abstract Full Text View citing articles Show Details

Area Of Sterile Zone

Antibiotic

Pharmaceutical Chemistry...

Title/Abstract Full Text View citing articles Show Details

Ovsyannikova; Vol'Eva; Belostotskaya; Komissarova; Malkova; Kurkovskaya

Pharmaceutical Chemistry Journal, 2013 , vol. 47, # 3 p. 142 - 145 Title/Abstract Full Text View citing articles Show Details

Area Of Sterile Zone

mm2

Antibiotic

Pharmaceutical Chemistry...

Title/Abstract Full Text View citing articles Show Details

Ovsyannikova; Vol'Eva; Belostotskaya; Komissarova; Malkova; Kurkovskaya

Pharmaceutical Chemistry Journal, 2013 , vol. 47, # 3 p. 142 - 145 Title/Abstract Full Text View citing articles Show Details

Area Of Sterile Zone

Antibiotic

Pharmaceutical Chemistry...

Title/Abstract Full Text View citing articles Show Details

Ovsyannikova; Vol'Eva; Belostotskaya; Komissarova; Malkova; Kurkovskaya

Pharmaceutical Chemistry Journal, 2013 , vol. 47, # 3 p. 142 - 145 Title/Abstract Full Text View citing articles Show Details

Area Of Sterile Zone

mm2

Antibiotic

Pharmaceutical Chemistry...

Title/Abstract Full Text View citing articles Show Details

Ovsyannikova; Vol'Eva; Belostotskaya; Komissarova; Malkova; Kurkovskaya

Pharmaceutical Chemistry Journal, 2013 , vol. 47, # 3 p. 142 - 145 Title/Abstract Full Text View citing articles Show Details

% Increase

75.3

0.1 % (v/v)

International Journal of...

Title/Abstract Full Text View citing articles Show Details

Xu, Xiangqun; Quan, Lili; Shen, Mengwei

International Journal of Biological Macromolecules, 2015 , vol. 77, p. 143 - 150 Title/Abstract Full Text View citing articles Show Details

% Increase

Active

0.1 % (v/v)

International Journal of...

Title/Abstract Full Text View citing articles Show Details

Xu, Xiangqun; Quan, Lili; Shen, Mengwei

International Journal of Biological Macromolecules, 2015 , vol. 77, p. 143 - 150 Title/Abstract Full Text View citing articles Show Details

% Increase

Active

0.1 % (v/v)

International Journal of...

Title/Abstract Full Text View citing articles Show Details

Xu, Xiangqun; Quan, Lili; Shen, Mengwei

International Journal of Biological Macromolecules, 2015 , vol. 77, p. 143 - 150 Title/Abstract Full Text View citing articles Show Details

Activity

Patent: US7794993 B2, ...

Title/Abstract Full Text Show Details

Patent: US7794993 B2, ...

Title/Abstract Full Text Show Details

Patent: US2010/317075 ...

Title/Abstract Full Text Show Details

Kaneka Corporation

Patent: US7794993 B2, 2010 ; Title/Abstract Full Text Show Details

Activity

Kaneka Corporation

Patent: US7794993 B2, 2010 ; Title/Abstract Full Text Show Details

Activity

SOUICHI MORIKAWA; NORIYUKI KIZAKI; MIHO YANO; MASAHIRO FUNAKI; TERUAKI TAKESUE; YOSHIHIKO YASOHARA; TAKAHISA NAKAI; MICHIHIKO KATAOKA; SAKAYU SHIMIZU

Patent: US2010/317075 A1, 2010 ; Title/Abstract Full Text Show Details

Activity

Patent: US2010/317075 ...

Title/Abstract Full Text Show Details

SOUICHI MORIKAWA; NORIYUKI KIZAKI; MIHO YANO; MASAHIRO FUNAKI; TERUAKI TAKESUE; YOSHIHIKO YASOHARA; TAKAHISA NAKAI; MICHIHIKO KATAOKA; SAKAYU SHIMIZU

Patent: US2010/317075 A1, 2010 ; Title/Abstract Full Text Show Details

Inhibitor

phospholipase/lipase MPlaG:Wild

20 %

Patent: EP2784160 B1, ...

Title/Abstract Full Text Show Details

Korea Research Institute of Bioscience and Biotechnology; YOON, Jung-Hoon; LEE, Mi Hwa; KANG, Chul Hyung; OH, Ki Hoon; OH, Tae Kwang

Patent: EP2784160 B1, 2016 ; Title/Abstract Full Text Show Details

Inhibitor

phospholipase/lipase MPlaG:Wild

50 %

Korea Research Institute of Bioscience and Biotechnology; YOON, Jung-Hoon; LEE, Mi Hwa; KANG, Chul Hyung; OH, Ki Hoon; OH, Tae Kwang

Patent: EP2784160 B1, 2016 ; Title/Abstract Full Text Show Details

Patent: EP2784160 B1, ...

Title/Abstract Full Text Show Details

Inhibitor

phospholipase/lipase MPlaG:Wild

60 %

Patent: EP2784160 B1, ...

Title/Abstract Full Text Show Details

Korea Research Institute of Bioscience and Biotechnology; YOON, Jung-Hoon; LEE, Mi Hwa; KANG, Chul Hyung; OH, Ki Hoon; OH, Tae Kwang

Patent: EP2784160 B1, 2016 ; Title/Abstract Full Text Show Details

Active

Stimulator

Fibrinolytic enzyme [Serratia]:Wild

Fibrinolytic

3 Biotech, 2017 , vol. ...

Title/Abstract Full Text View citing articles Show Details

Taneja, Kapila; Bajaj, Bijender Kumar; Kumar, Sandeep; Dilbaghi, Neeraj

3 Biotech, 2017 , vol. 7, # 3 art. no. 184 Title/Abstract Full Text View citing articles Show Details

% Inhibition

Inhibitor

cellulase:Wild

30 % (v/v)

Applied Biochemistry and...

Title/Abstract Full Text View citing articles Show Details

Irfan, Muhammad; Tayyab, Ammara; Hasan, Fariha; Khan, Samiullah; Badshah, Malik; Shah, Aamer Ali

Applied Biochemistry and Biotechnology, 2017 , vol. 182, # 4 p. 1390 - 1402 Title/Abstract Full Text View citing articles Show Details

% Inhibition

Inhibitor

cellulase:Wild

30 % (v/v)

Applied Biochemistry and...

Title/Abstract Full Text View citing articles Show Details

Irfan, Muhammad; Tayyab, Ammara; Hasan, Fariha; Khan, Samiullah; Badshah, Malik; Shah, Aamer Ali

Applied Biochemistry and Biotechnology, 2017 , vol. 182, # 4 p. 1390 - 1402 Title/Abstract Full Text View citing articles Show Details

% Inhibition

Inhibitor

cellulase:Wild

30 % (v/v)

Applied Biochemistry and...

Title/Abstract Full Text View citing articles Show Details

Irfan, Muhammad; Tayyab, Ammara; Hasan, Fariha; Khan, Samiullah; Badshah, Malik; Shah, Aamer Ali

Applied Biochemistry and Biotechnology, 2017 , vol. 182, # 4 p. 1390 - 1402 Title/Abstract Full Text View citing articles Show Details

% Inhibition

Inhibitor

cellulase:Wild

30 % (v/v)

Applied Biochemistry and...

Title/Abstract Full Text View citing articles Show Details

Irfan, Muhammad; Tayyab, Ammara; Hasan, Fariha; Khan, Samiullah; Badshah, Malik; Shah, Aamer Ali

Applied Biochemistry and Biotechnology, 2017 , vol. 182, # 4 p. 1390 - 1402 Title/Abstract Full Text View citing articles Show Details

% residual activity

Inhibitor

cellulase:Wild

30 % (v/v)

Applied Biochemistry and...

Title/Abstract Full Text View citing articles Show Details

Irfan, Muhammad; Tayyab, Ammara; Hasan, Fariha; Khan, Samiullah; Badshah, Malik; Shah, Aamer Ali

Applied Biochemistry and Biotechnology, 2017 , vol. 182, # 4 p. 1390 - 1402 Title/Abstract Full Text View citing articles Show Details

% Inhibition

Inhibitor

cellulase:Wild

30 % (v/v)

Applied Biochemistry and...

Title/Abstract Full Text View citing articles Show Details

Irfan, Muhammad; Tayyab, Ammara; Hasan, Fariha; Khan, Samiullah; Badshah, Malik; Shah, Aamer Ali

Applied Biochemistry and Biotechnology, 2017 , vol. 182, # 4 p. 1390 - 1402 Title/Abstract Full Text View citing articles Show Details

% Inhibition

Inhibitor

cellulase:Wild

30 % (v/v)

Applied Biochemistry and...

Title/Abstract Full Text View citing articles Show Details

Irfan, Muhammad; Tayyab, Ammara; Hasan, Fariha; Khan, Samiullah; Badshah, Malik; Shah, Aamer Ali

Applied Biochemistry and Biotechnology, 2017 , vol. 182, # 4 p. 1390 - 1402 Title/Abstract Full Text View citing articles Show Details

Qualitative Information

1 of 141

Effect Assay Description

2 of 141

3 of 141

4 of 141

5 of 141

6 of 141

Antimutagenic

Target : Salmonella typhimurium TA 100 Bioassay : inhibition of direct-acting mutagenicity of 4-NQO 4-nitroquinoline (4-NQO) as mutagenic agent; standard plate incorporation assay; 37 deg C

Citation

De Flora; Rosenkranz; Klopman

Mutagenesis, 1994 , vol. 9, # 1 p. 39 - 45 Title/Abstract Full Text View citing articles Show Details

Effect

Toxic

Assay Description

Effect : bioluminescence Target : Alcaligenes eutropus 2050 Bioassay : Microtox test; vehicle water, 25 deg C

Results

log(IC50)-1 -2.55-2.78 mM

Citation

Layton; Gregory; Schultz; Sayler

Ecotoxicology and Environmental Safety, 1999 , vol. 43, # 2 p. 222 - 228 Title/Abstract Full Text View citing articles Show Details

Effect

Toxic

Assay Description

Effect : bioluminescence Target : Stenotrophomonas 3664 Bioassay : Microtox test; vehicle water, 25 deg C

Results

log(IC50)-1 -2.32-2.33 mM

Citation

Layton; Gregory; Schultz; Sayler

Ecotoxicology and Environmental Safety, 1999 , vol. 43, # 2 p. 222 - 228 Title/Abstract Full Text View citing articles Show Details

Effect

Toxic

Biological material

Aliivibrio fischeri

Assay Description

Effect : bioluminescence Bioassay : Microtox test; vehicle saline, 25 deg C

Results

log (IC50)-1 -2.35-2.42 mM

Citation

Layton; Gregory; Schultz; Sayler

Ecotoxicology and Environmental Safety, 1999 , vol. 43, # 2 p. 222 - 228 Title/Abstract Full Text View citing articles Show Details

Results

no promotion of the growth of Arabidopsis thaliana, tested concentration 1-100 g/liter

Citation

Kato; Ohnishi; Takahashi; Wang Zheng-Yu; Nozawa

Bioscience, Biotechnology and Biochemistry, 1996 , vol. 60, # 1 p. 34 - 38 Title/Abstract Full Text Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; examination of Bioassay : one unit of enzyme activity = oxidation of 1 μmol/l NADPH/min at 30 deg C and pH 7.4 enzyme purified from liver cytosol; 1.0 mmol/l enzyme incubated with title comp., decrease in absorbance at 340 nm measured; Km and Vmax determined from Lineweaver-Burk plots

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Results

Vmax not detected

Citation

Kobana, Kiyofumi; Watanabe, Kazuhito; Kimura, Toshiyuki; Matsunaga, Tamihide; Kondo, Shigemi; Yamamoto, Ikuo

Biological and Pharmaceutical Bulletin, 2000 , vol. 23, # 8 p. 917 - 921 Title/Abstract Full Text View citing articles Show Details

Effect

Toxic

Biological material

Tetrahymena pyriformis

Assay Description

Effect : immobilization Bioassay : ciliate from American Tissue Type Collection, MD, USA; cell density between 1E2 and 1E4 cells/mL; yeast media Motility Assay; cells exposure to test chemical; cell-tracking parameters automated monitoring

Results

average tolerated dose average tolerated dose as the reciprocal sum of the high (90 percent motile) and low (10 percent motile) dose 71400 dilution factor

Citation

Noever; Matsos; Cronise; Looger; Relwani; Johnson

Chemosphere, 1994 , vol. 29, # 6 p. 1373 - 1384 Title/Abstract Full Text View citing articles Show Details

Biological material

Mus musculus

Assay Description

Effect : Langerhans cell migration; induction of Bioassay : Induction of Langerhans Cell Migration by Dibutylphthalate Fluorescein isothiocyanate (FITC) has been used extensively by the inventor and others, to characterize Langerhans cell migration. FITC is a small (mw 389) non-peptide, largely lipophilic molecule, capable of crossing the stratum corneum. Immunogenicity

Citation

TORREY PINES INSTITUTE FOR MOLECULAR STUDIES

Patent: EP1071411 B1, 2007 ; Title/Abstract Full Text Show Details

Assay Description

Effect : carbohydrolase (LSA) enzyme activity; effect on Target : carbohydrolase (LSA) enzyme of Lipomyces starkeyi KFCC 11077 Bioassay : EXAMPLE 4 Effect of Metal Ions, Chelating Solutions and Denaturizing Solutions on Enzyme Activity Effects of EDTA, EGTA and metal ions on enzyme activity were measured. EDTA and EGTA were each used at a final concentration of 1 mM. As for metal ions, they included ZnCl2, CuS04,

Results

10-40% of title compound increased the activity of carbohydrolase (LSA) enzyme by 1.03-1.22 fold; LSA enzyme showed lower than 50% of the optical activity; figure is given

Citation

LIFENZA CO., LTD.

Patent: US2007/77212 A1, 2007 ; Title/Abstract Full Text Show Details

Results

effect on debromination of (α-bromisovaleryl)urea by rat liver microsomes

Citation

Oka, Koji; Kitamura, Shigeyuki; Tatsumi, Kiyoshi

Journal of Pharmacy and Pharmacology, 1996 , vol. 48, # 9 p. 930 - 932 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; examination of Bioassay : one unit of enzyme act. defined as enzyme catalyzing 1 μmol of NADH formation in ketone reduction; specific act. - enzyme act./mg of protein test sp. from cytosolic fr. of Gluconobacter frateurii CHM 9; enzyme act. measured by recording rate decrease of NADH at 340 nm at 25 deg C, pH 6.0

Results

enzyme catalyzed reduction of title comp. to alcohol

Citation

Moonmangmee; Fujii; Toyama; Theeragool; Lotong; Matsushita; Adachi

Bioscience, biotechnology, and biochemistry, 2001 , vol. 65, # 12 p. 2763 - 2772 Title/Abstract Full Text View citing articles Show Details

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Target

enzyme:Wild

Assay Description

Effect : |enzyme; examination of Bioassay : one unit of enzyme act. defined as enzyme catalyzing 1 μmol of substrate reduction per min; specific act. defined as enzyme act./mg of protein test sp. from Gluconobacter frateurii CHM 9; enzyme used as purified from membrane and containing in membrane fraction of organism; enzyme act. measured with potassium ferricyanide or phenazine methosulfate + 2,6-dichlorophenol indophenol at pH 5.0

Results

enzyme not catalyzed reduction of title comp.

Citation

Moonmangmee; Fujii; Toyama; Theeragool; Lotong; Matsushita; Adachi

Bioscience, biotechnology, and biochemistry, 2001 , vol. 65, # 12 p. 2763 - 2772 Title/Abstract Full Text View citing articles Show Details

Assay Description

Bioassay : the relative composition of the emitted gas from a Municipal Landfill Site may vary from one site to another depending on the type of waste buried, the stage reached in the decomposition process as well as operating conditions at the site

Results

emissions affect the ambient air quality of the surrounding area and contribute to increase concentration levels of contaminants

Citation

Brosseau; Heitz

Atmospheric Environment, 1994 , vol. 28, # 2 p. 285 - 293 Title/Abstract Full Text Show Details

Assay Description

Effect : |respiratory Target : beef heart mitochondria Bioassay : reaction medium (2 ml) was kept termostated at 25 deg C; EC50 values were obtained with succinate as substrate mitochondria from beef heart; exposure to test chemical in medium containing 0.25 M sucrose, 10 mM Tris, 5 mM succinate, 5 mM inorganic phosphate; assayed for ATP content using Greengard's enzyme assay

Results

EC50 inhibition of respiratory rate 1.0 10000000 ppb

Citation

Bragadin; Dell'Antone

Archives of Environmental Contamination and Toxicology, 1994 , vol. 27, # 3 p. 410 - 414 Title/Abstract Full Text Show Details

Target

enzyme:Wild

Biological material

Rattus norvegicus

Assay Description

Effect : |enzyme; induction of Bioassay : in methanol and Tris-HCl (pH 7.4) containing Tween 20, bovine serum albumin, NADH; enzyme activity measured spectrophotometrically; avearages of five parallel measurements 100-150 g body weight animals; liver excised; cytosolic fraction isolated; DT-diaphorase (EC 1.6.99.2) activity with menadione as a substrate in hepatic cytosol determined

Results

protein content (mg/ml) and spec. activity (units/ml) in hepatic cytosol: 23.1 (control 19.0) and 0.67 (control 0.79)

Citation

Stiborova, Marie; Hajek, Miroslav; Vosmikova, Hana; Frei, Eva; Schmeiser, Heinz H.

Collection of Czechoslovak Chemical Communications, 2001 , vol. 66, # 6 p. 959 - 972 Title/Abstract Full Text View citing articles Show Details

Results

molar solubilities in blood

Citation

Kamlet; Abraham; Doherty; Taft

Journal of Pharmaceutical Sciences, 1986 , vol. 75, # 4 p. 350 - 355 Title/Abstract Full Text View citing articles Show Details

Results

decrease of N-desmethyltamoxifen (39-63percent) and 4-hydroxytamoxifen (45-69percent) production in the course of in vitro metabolism of tamoxifen by human liver microsomes, 5percent of the incubation volume

Citation

Cotreau-Bibbo, Monette M.; Von Moltke, Lisa L.; Greenblatt, David J.

Journal of Pharmaceutical Sciences, 1996 , vol. 85, # 11 p. 1180 - 1185 Title/Abstract Full Text View citing articles Show Details

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Effect

Hematological

Biological material

Rattus norvegicus

Assay Description

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Bioassay : rats under 12-h dark/light cycle; 50 μl dose; injected into one hind footpad morphometric and morphologic studies of popliteal lymph node (PLN)

Results

PLN showed: no blurring of lymph node architecture, slight increase in the percentage of immunoblasts from paracortical areas, and plasma cells from medullary areas; no acute inflammatory changes

Citation

Brouland; Verdier; Patriarca; Vial; Descotes

Journal of Toxicology and Environmental Health, 1994 , vol. 41, # 1 p. 95 - 108 Title/Abstract Full Text View citing articles Show Details

Effect

Toxic

Biological material

Rattus norvegicus

Assay Description

Bioassay : rats under 12-h dark/light cycle; 50 μl dose; injected into one hind footpad

Results

significant increase in the weight of popliteal lymph node (PLN)

Citation

Brouland; Verdier; Patriarca; Vial; Descotes

Journal of Toxicology and Environmental Health, 1994 , vol. 41, # 1 p. 95 - 108 Title/Abstract Full Text View citing articles Show Details

Assay Description

Effect : transcription; increase of Target : FSKC expressing LR plasmid contg. CD80 promoter construct Bioassay : human foreskin keratinocytes (FSKC) from four donors used; control: untreated cells; LR: luciferase reporter keratinocyte cultures treated with title comp. for 48 h; cells lysed; luciferase expression measured using either luciferase assay system or dual-luciferase reporter assay system

Results

title comp. treated keratinocytes from donors 1 and 2 were non-responsive (no increase in CD80 transcription)and from donor 3 and 4, intermediate response were observed; table, fig.

Citation

Wakem, Paul; Ramirez, Francisco; Zlotnick, David; Gaspari, Anthony A.

Journal of Applied Toxicology, 2004 , vol. 24, # 6 p. 485 - 492 Title/Abstract Full Text View citing articles Show Details

Biological material

Mus musculus

Assay Description

Effect : natural pigmentation; effect on Example 5Measurement of the Depigmenting Activity of the Combination of Adapalene and a Depigmenting AgentThe evaluation of the depigmenting and/or anti-pigmenting activity of 3% hydroquinone and of 0.1% adapalene, alone or in combination for 8 weeks, is carried out on the tail of an SKH:HR2 mouse irradiated

Citation

GALDERMA RESEARCH AND DEVELOPMENT

Patent: US2008/219936 A1, 2008 ; Title/Abstract Full Text Show Details

Biological material

Mus musculus

Assay Description

Effect : ultraviolet B (UV-B)-induced pigmentation; inhibition of Bioassay : ultraviolet B (UV-B) irradiated Example 5Measurement of the Depigmenting Activity of the Combination of Adapalene and a Depigmenting AgentThe evaluation of the depigmenting and/or anti-pigmenting activity of 3% hydroquinone and of 0.1% adapalene, alone or in combination for 8 weeks, is carried out on the tail of an SKH:HR2 mouse irradiated

Citation

GALDERMA RESEARCH AND DEVELOPMENT

Patent: US2008/219936 A1, 2008 ;

Title/Abstract Full Text Show Details

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Biological material

carnation

Assay Description

Effect : plant tissue fluid replacement As a cut flower, a carnation named &ldquo;Moondust Velvet Blue&rdquo; (available from Suntory Flowers Ltd.) was used. The petals of the carnation were immersed in various organic solvents listed in Table 1 for not less than one day, after which a determination was made as to whether the water contained

Results

water in plants was replaced; contraction and leach-out of pigment were not observed

Citation

SUNTORY FLOWERS LIMITED

Patent: US2009/119801 A1, 2009 ; Title/Abstract Full Text Show Details

Effect

Cytotoxic

Biological material

HeLa S3

Assay Description

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Bioassay : HeLa cells incubated with test comp. at 37 deg C in a 5 percent CO2 atmosphere in RPMI 1640 medium containing 10 percent FBS; microscopic observation; cell viability; protein detection; estimation of ATP/ADP content by luminescence assay

Citation

Forman; Kas; Fini; Steinberg; Ruml

Journal of biochemical and molecular toxicology, 1999 , vol. 13, # 1 p. 11 - 15 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; induction of Bioassay : hamsters, 80-100 g b.w., killed, livers, kidneys, lungs removed, microsomes and RNA prepared; gel electropheroses, immunoblot, protein blot, RNA blot, Northern blot analyses

Results

induced catalytic activity, protein and mRNA levels of P450s 1A, 2B, 2E in liver, caused various changes of P450 levels in kidney and lung

Citation

Chen, Ruei-Ming; Ueng, Tzuu-Huei

Archives of Toxicology, 1997 , vol. 71, # 8 p. 489 - 495 Title/Abstract Full Text View citing articles Show Details

Assay Description

Bioassay : static chamber; peat: organic content: 86.4 percent (dry weight), BET-(N2) surface area: 1.3-1.5 m2/g; 24 deg C

Results

sorption capacity and solubility of liquid in peat organic matter (from the vapour isotherm): partition capacity (Q0om): 171 mg/g, volume fraction solubility (Φ0): 0.22; vapour sorption isotherm

Citation

Chiou; Kile

Environmental Science and Technology, 1994 , vol. 28, # 6 p. 1139 - 1144 Title/Abstract Full Text View citing articles Show Details

Effect

Genotoxic

Assay Description

Target : Saccharomyces cerevisiae D61.M, yeast Bioassay : yeast cultures incubated 4-h at 28 deg C in a water bath shaker, followed by an overnight holding at 4 deg C in a refrigerator, and then a second 4-h incubation at 28 deg C; 12E7 cells/ml chromosome loss and genetic events determined; YEPD medium; surviving colony counts; cycloheximide-YEPD plates

Results

survival ( percent): 106, 86, 72 and 82 at 201, 266, 331 and 395 mM, resp.; frequency of chromosome loss events per 1E6 cfu: 4.5-9.3; frequency of red cyhR colonies per 1E5: 26.6-29.1

Citation

Wiley; Raabe; Khan; Straume

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1994 , vol. 309, # 1 p. 83 - 92 Title/Abstract Full Text View citing articles Show Details

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Effect Assay Description

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Behavioural Symptoms

Target : Elephas maximus, Asian elephant Bioassay : 3 elephants; ca. 400 ml of sample released identified in temporal gland secretion (TGS); bioassays in the Metro Washington Park Zoo, Portland, Oregon; in 850-ml canisters; 30 psig zero air; contents of the canisters vented to the end of the elephant's trunk; avoidance reactions elicited

Results

did not elicit any avoidance reactions; number of backing up responses: 0 (zero air: 0); number of times compound bioasayed: 12 (zero air: 16)

Citation

Perrin, Thomas E.; Rasmussen; Gunawardena, Rohith

Journal of Chemical Ecology, 1996 , vol. 22, # 2 p. 207 - 221 Title/Abstract Full Text View citing articles Show Details

Target

Myeloperoxidase:Wild

Assay Description

Effect : |enzyme; examination of Bioassay : 0.2 ml applied topically to female mice CD-1; after killing MPO extraction from 22-mm diameter dorsal skin from polymorphonuclear leucocytes (PMNs) spectrophotometrically; MPO accumulation in mouse skin

Results

ability to elicit the accumulation of MPO as myeloperoxidase activity: 0.03 +/- 0.01 (units/22 mm skin punch); 1 unit of MPO activity is equivalent to 8.6*106 murine PMNs

Citation

Trush; Egner; Kensler

Food and Chemical Toxicology, 1994 , vol. 32, # 2 p. 143 - 147 Title/Abstract Full Text Show Details

Results

no mutagenicity toward Salmonella typhimurium

Citation

Yamaguchi, Tsutomu

Agricultural and Biological Chemistry, 1987 , vol. 51, # 1 p. 167 - 172 Title/Abstract Full Text Show Details

Results

no reduction activity in test on substrate specificity of glycerol dehydrogenase from Cellulomonas sp. NT3060 at 50 mM

Citation

Yamada, Hideaki; Nagao, Akihiko; Nishise, Hiroshi; Tani, Yoshiki

Agricultural and Biological Chemistry, 1982 , vol. 46, # 9 p. 2333 - 2340 Title/Abstract Full Text Show Details

Effect

Phytotoxic

Assay Description

Effect : discoloration and wilting of leaves Target : Pinus thunbergii, Japanese black pine Bioassay : pot-grown 4-year-old trees, 40 cm in hight, 1.6 cm in basal diameter, kept in greenhouse for 4 months prior to study; injection into the hole (3*10 mm); observation for 1 month

Results

no enjurious effect excerpt discoloration of the cambiun around the injection hole

Citation

Takai, Kazuya; Soejima, Tomoyuki; Suzuki, Toshio; Kawazu, Kazuyoshi

Pest Management Science, 2001 , vol. 57, # 5 p. 463 - 466 Title/Abstract Full Text View citing articles Show Details

Assay Description

Bioassay : dynamic sorption experiment; brown Mediterranean soil (Sicily): 3.31 percent sand, 21.90 percent silt, 75.00 percent clay, pH 5.9, specific surface area 15.86 m2/g; at 15 deg C, gas-phase relative humidity of 50, 70 and 90 percent; sorption constant determined by inverse GC

Results

sorption log of sorption constant (Ksa): log Ksa = 3.56 and 2.82 at relative humidity of 50 and 90 percent, resp.; table, diagrams

Citation

Goss, Kai-Uwe; Buschmann, Johanna; Schwarzenbach, Rene P.

Environmental Science and Technology, 2004 , vol. 38, # 13 p. 3667 - 3673 Title/Abstract Full Text View citing articles Show Details

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Assay Description

Bioassay : dynamic sorption experiment; soil (loess sample, Iowa) texture: 7.1 percent sand, 75.6 percent silt, 17.4 percent clay, pH 8.34, specific surface area 15.86 m2/g; at 15 deg C, gas-phase relative humidity of 50, 70 and 90 percent; sorption constant determined by inverse GC

Results

sorption log of sorption constant (Ksa): log Ksa = 3.17, 2.67 and 2.23 at relative humidity of 50, 70 and 90 percent, resp.; table, diagrams

Citation

Goss, Kai-Uwe; Buschmann, Johanna; Schwarzenbach, Rene P.

Environmental Science and Technology, 2004 , vol. 38, # 13 p. 3667 - 3673 Title/Abstract Full Text View citing articles Show Details

Assay Description

Bioassay : fixed-bed adsorption experiment; 23 deg C; experiment duration: 18 days; title comp. in mixture with toluene (550 ppmv); contaminated air supplied 8 h/day and uncontaminated air supplied 16 h/day; photoacoustic multigas monitor used

Results

adsorption breakthrough curve presented; diagram

Citation

Li, Congna; Moe, William M.

Environmental Science and Technology, 2005 , vol. 39, # 7 p. 2349 - 2356 Title/Abstract Full Text View citing articles Show Details

Assay Description

Bioassay : fixed-bed adsorption experiment; 23 deg C; experiment duration: 21 days; air contaminated with title comp. supplied 8 h/day and uncontaminated air supplied 16 h/day; influent title comp. conc.: 243-960 ppmv; photoacoustic multigas monitor used

Results

adsorption breakthrough curve presented; breakthrough occurred after 2.4 days; diagram

Citation

Li, Congna; Moe, William M.

Environmental Science and Technology, 2005 , vol. 39, # 7 p. 2349 - 2356 Title/Abstract Full Text View citing articles Show Details

Results

no mutagenicity on Salmonella typhimurium AT 100 with or without S-9 Mix

Citation

Yamaguchi

Agricultural and Biological Chemistry, 1982 , vol. 46, # 3 p. 849 - 851 Title/Abstract Full Text View citing articles Show Details

Results

insecticidal activity against Periplanata americana - mean killing time 40.0 h at conc. 0.5percent , 40.0 h at conc. 0.1percent

Citation

Misra

Archiv der Pharmazie, 1983 , vol. 316, # 6 p. 487 - 493 Title/Abstract Full Text View citing articles Show Details

Assay Description

Effect : delipidization Target : CRD-CD hairless rats Bioassay : rats, 6-8 wks old; animals anesthetized, title compound applied directly to dorsal site; mannitol or progesterone, each at 2.5 mg/ml applied; aminals euthanized, skin excised, laparotomy performed to remove urine, liver, blood

Results

not remarkable enhancement of systemic mannitol transport, ca. 5 percent of applied dose in urine; mannitol not detected in liver, blood, 1.6 percent deposition into viable skin; resulted in higher levels of progesterone in urine and liver

Citation

Lauer; Elder; Weiner

Journal of pharmaceutical sciences, 1997 , vol. 86, # 1 p. 13 - 18 Title/Abstract Full Text View citing articles Show Details

Assay Description

Effect : delipidization Target : Sprague-Dawley hairy rats Bioassay : rats, 6-8 wks old; animals anesthetized, title compound applied directly to dorsal site; mannitol or progesterone, each at 2.5 mg/ml applied; aminals euthanized, skin excised, laparotomy performed to remove urine, liver, blood

Results

remarkable enhancement of systemic mannitol transport, >30 percent of applied dose; mannitol not detected in liver, blood, 1.6 percent deposition into viable skin; resulted in higher levels

of progesterone in urine and liver

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Citation

Lauer; Elder; Weiner

Journal of pharmaceutical sciences, 1997 , vol. 86, # 1 p. 13 - 18 Title/Abstract Full Text View citing articles Show Details

Target

enzyme [Anguilla anguilla]:Wild

Assay Description

Effect : |enzyme; examination of Bioassay : eel, 20-30 g body wt, 16-20 cm in length, 20 deg C, total hardness, 240 ppm CaCO3, pH, 7.9, alkalinity, 4.0 mmol/l; eels anesthetized, brains dissected, homogenized, pH 7.2; AChE activity determination

Citation

Sancho; Ferrando; Andreu

Ecotoxicology and Environmental Safety, 1997 , vol. 38, # 3 p. 205 - 209 Title/Abstract Full Text View citing articles Show Details

Effect

Toxic

Biological material

Aliivibrio fischeri

Assay Description

Bioassay : acute Microtox test, bacteria cultured, harvested, maintained at -70 deg C in DMSO, thawed, vehilce, DMSO

Results

logarithm of the inverse of 15-min toxicity, pT15, -2.45

Citation

Cronin, Mark T. D.; Schultz, T. Wayne

Ecotoxicology and Environmental Safety, 1998 , vol. 39, # 1 p. 65 - 69 Title/Abstract Full Text View citing articles Show Details

Effect

Plant growth

Biological material

carrot

Assay Description

Bioassay : growth of Ri t-DNA-transformed carrot roots observation

Results

root growth inhibited at 50000 ppm

Citation

Wan, Michael T.; Rahe, James E.

Environmental Toxicology and Chemistry, 1998 , vol. 17, # 10 p. 2041 - 2050 Title/Abstract Full Text View citing articles Show Details

Effect

Toxic

Assay Description

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Target : vesicular-arbuscular mycorrhizae Bioassay : mycorrhizae in Ri t-DNA-transformed Daucus carota L. carrot roots by Glomus intraradices, colonization determination

Results

reduced colonization of carrot roots at 50000 ppm

Citation

Wan, Michael T.; Rahe, James E.

Environmental Toxicology and Chemistry, 1998 , vol. 17, # 10 p. 2041 - 2050 Title/Abstract Full Text View citing articles Show Details

Effect

Behavioural Symptoms

Biological material

goldfish

Assay Description

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Citation

Saglio; Trijasse

Archives of Environmental Contamination and Toxicology, 1998 , vol. 35, # 3 p. 484 - 491 Title/Abstract Full Text View citing articles Show Details

Assay Description

Effect : |protein binding Target : Mus musculus, CD-1 mouse Bioassay : mouse 12 wks old, animals killed, liver removed, microsomes prepared, 96-well plates; ELISA

Results

total CYP content, 1.23 nmol/mg protein; did not reacted with anti-peptide IgC on immunoblots

Citation

Lin, Song; Bullock, Peter L.; Addison, Richard F.; Bandiera, Stelvio M.

Environmental Toxicology and Chemistry, 1998 , vol. 17, # 3 p. 439 - 445 Title/Abstract Full Text View citing articles Show Details

Assay Description

Effect : toxicity to plant cell culture Target : Nicotiana tabacum L. cv. Bel B, tobacco Bioassay : 7-d old culture; electrical conductivity-medium; measurements at 120 rpm and 25 deg C; conc.: 1 percent (v/v) measurements of ion leakage

Results

no increase in medium conductivity

Citation

Koch; Glatzle; Ringenbach; Dunz; Steger-Hartmann; Wagner

Bulletin of Environmental Contamination and Toxicology, 1995 , vol. 54, # 4 p. 606 - 613 Title/Abstract Full Text Show Details

Effect

Behavioural Symptoms

Assay Description

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Target : Nereis (Neanthes) arenaceodentata, marine polychaete worm Bioassay : immature adult worms; 3 percent seawater, Instant Ocean, Mentor, Ohio; TetraMarin-alflafa food slurry, 3 times/week; influence on behavior and excess mucus production

Citation

Emery Jr.; Dillon

Bulletin of Environmental Contamination and Toxicology, 1996 , vol. 56, # 2 p. 265 - 270 Title/Abstract Full Text Show Details

Effect

Reproductive Effect

Assay Description

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Bioassay : juvenile fish, 6-8 cm length, 6-9 g body wt., 16-17.6 deg C, pH 7-7.3, static contaminated water; behavioral responses observation

Target : Nereis (Neanthes) arenaceodentata, marine polychaete worm Bioassay : immature adult worms; 3 percent seawater, Instant Ocean, Mentor, Ohio; TetraMarin-alflafa food slurry, 3 times/week

Results

significant and positive effect: emergent juvenile production 201/brood, control 97/brood

Citation

Emery Jr.; Dillon

Bulletin of Environmental Contamination and Toxicology, 1996 , vol. 56, # 2 p. 265 - 270 Title/Abstract Full Text Show Details

Assay Description

Bioassay : natural bentonite from Zhejiang Province (China) modified with cetyltrimethylammonium bromide; organic carbon content (wt percent): 11.47; surface area: 7.9 m2/g; micropore volume: 0.015 ml/g; elution by characteristic points; inverse gas chromatography

Results

sorption gas-solid partition coefficient Kc at 353 K: 156.41 ml/g

Citation

Tian, Senlin; Zhu, Lizhong; Shi, Yao

Environmental Science and Technology, 2004 , vol. 38, # 2 p. 489 - 495 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

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Assay Description

Effect : |enzyme; examination of Bioassay : control animals received 5 ml of water by gavage; CZX - chlorzoxazone animals 3 month old; 3-4/group; free access to food and water; sacrif. 12 h after title comp. admin.; liver, lung removed, homogenized, centrifuged; microsomes prepared; CYP2E1 activity assessed by measuring CZX hydroxylation; products det. by HPLC

Results

CYP2E1 activity increased in liver (lung) from 0.49 (0.06) to 1.30 (0.10) nmol/mg protein/min after title compound treatment

Citation

Wang, Hongbing; Chanas, Brian; Ghanayem, Burhan I.

Journal of Toxicology and Environmental Health - Part A, 2002 , vol. 65, # 7 p. 523 - 537 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; examination of Bioassay : control animals received 5 ml of water by gavage; RT-PCR - reverse-transcription polymerase chain reaction; RNA isolated using RNeasy Mini kit; CYP2E1 - cytochrome P450 2E1 animals 3 month old; 3-4/group; free access to food and water; sacrif. 12 h after title comp. admin.; lung, liver, olfactory epithelium removed; CYP2E1 mRNA isolated; RT-PCR conducted; products separated by electrophoresis

Results

after title compound treatment observed significant increase of CYP2E1 mRNA in lung

Citation

Wang, Hongbing; Chanas, Brian; Ghanayem, Burhan I.

Journal of Toxicology and Environmental Health - Part A, 2002 , vol. 65, # 7 p. 523 - 537 Title/Abstract Full Text View citing articles Show Details

Assay Description

Effect : natural pigmentation; effect on Target : SKH:HR2 mouse Bioassay : Example 5Measurement of the Depigmenting Activity of the Combination of Adapalene and a Depigmenting AgentThe evaluation of the depigmenting and/or anti-pigmenting activity of 3% hydroquinone and of 0.1% adapalene, alone or in combination for 8 weeks, is carried out on the tail of an SKH:HR2 mouse irradiated

Citation

Isabelle, Pelisson; Andre, Jomard

Patent: US2008/219936 A1, 2008 ; Title/Abstract Full Text Show Details

Assay Description

Effect : ultraviolet B (UV-B)-induced pigmentation; inhibition of Target : ultraviolet B (UV-B) irradiated of SKH:HR2 mouse Bioassay : Example 5Measurement of the Depigmenting Activity of the Combination of Adapalene and a Depigmenting AgentThe evaluation of the depigmenting and/or anti-pigmenting activity of 3% hydroquinone and of 0.1% adapalene, alone or in combination for 8 weeks, is carried out on the tail of an SKH:HR2 mouse irradiated

Citation

Isabelle, Pelisson; Andre, Jomard

Patent: US2008/219936 A1, 2008 ; Title/Abstract Full Text Show Details

Assay Description

Bioassay : Militant fly ash as sorbent; adsorption equilibria/isotherm study: tumbled-bottle batch reactor, 72 h, 20 deg C

Results

adsorption Freundlich sorption capacity (k): 11.60, intensity parameters (1/n): 0.60

Citation

Banerjee; Cheremisinoff; Su Ling Cheng

Environmental Science and Technology, 1995 , vol. 29, # 9 p. 2243 - 2251 Title/Abstract Full Text Show Details

Effect

Toxic

Biological material

Daphnia magna

Assay Description

Citation

Bioassay : 20 deg C; standard reconstituted water; 48-h LC50: 131 mmol/l; exposure to lethal levels (48-h LC50): 24 h parthenogenetic female; effect of sublethal (50 percent, 25 percent, 12.5 percent, and 6.3 percent of 48-h LC50) exposure on lethal body burdens; 14C-labeled title comp., sp. activity 0.27 MBq/mmol Pawlisz; Peters

Environmental Science and Technology, 1995 , vol. 29, # 3 p. 613 - 621 Title/Abstract Full Text Show Details

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Effect Assay Description

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Target : Saccharomyces cerevisiae D61.M, diploid yeast Bioassay : liquid YEPD medium; incubation cond. without S9-mix: 30 deg C for 4 h, with S9-mix: 2 h at 37 deg C, 2 h at 30 deg C with and without metabolic activation (S9-mix; from liver homogenate of Aroclor 1254 induced rats)

Results

survivors without S9-mix: 25.1-25.2 percent (139.2 percent), with S9-mix: 1.0 percent (100.6 percent) (untreated control in parentheses)

Citation

Steher-Schmid; Wolf

Mutation Research - Genetic Toxicology, 1995 , vol. 345, # 3-4 p. 111 - 125 Title/Abstract Full Text View citing articles Show Details

Effect

Mutagenic

Assay Description

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Cytotoxic

Target : Saccharomyces cerevisiae D61.M, diploid yeast Bioassay : liquid YEPD medium; incubation cond. without S9-mix: 30 deg C for 4 h, with S9-mix: 2 h at 37 deg C, 2 h at 30 deg C genotoxicity; chromosome loss: test for leucineauxotrophy; induction of red and white cycloheximide-resistant colonies; with and without metabolic activation (S9-mix; from liver homogenate of Aroclor 1254 induced rats)

Results

increase of chromosome malsegregation and the frequencies of red and white cycloheximide-resistant colonies

Citation

Steher-Schmid; Wolf

Mutation Research - Genetic Toxicology, 1995 , vol. 345, # 3-4 p. 111 - 125 Title/Abstract Full Text View citing articles Show Details

Assay Description

Bioassay : chromatographic method; stainless steel column (10 cm length, 2 cm i.d.); α-Al2O3 at 60.5 deg C; α-Fe2O3 at 70 deg C; RH: 30-90 percent; determined by regression analysis; for α-Fe2O3 extrapolated to 60.5 deg C; particle sizes < 200 μm

Results

adsorption adsorption coefficient (cm) at 100 percent RH: 1.67E-4, 1.93E-4, slope of RH/ln K relationship C: -0.0106, -0.0187, for α-Al2O3, α-Fe2O3, resp.; diagrams

Citation

Goss, Kai-Uwe

Environmental Science and Technology, 1996 , vol. 30, # 7 p. 2135 - 2142 Title/Abstract Full Text View citing articles Show Details

Effect

Behavioural Symptoms

Biological material

Diabrotica virgifera virgifera

Assay Description

Effect : attraction Bioassay : second-instar larvae (5-7 days old, 4-7 mm long); two-choice bioassay; 23-27 deg C

Citation

Jewett; Bjostad

Journal of Chemical Ecology, 1996 , vol. 22, # 7 p. 1331 - 1344 Title/Abstract Full Text View citing articles Show Details

Effect

Toxic : Acute

Assay Description

Effect : mortality Target : Daphnia magna, Cladoceran Bioassay : 10 neonates, age < 24 hr; artificial pond water

Citation

Zou; Fingerman

Bulletin of Environmental Contamination and Toxicology, 1997 , vol. 58, # 4 p. 596 - 602 Title/Abstract Full Text View citing articles Show Details

Effect

Cytotoxic

Assay

Effect : lysosomal membrane response

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Description

Target : Mytilus edulis, mussel Bioassay : determination of neutral red retention time and lysosomal latency period; 100 percent in control in vitro; neutral red retention (NRR) assay; 90 mussels; 35-45 mm; from coast at Whitsand Bay, Cornwall; in seawater; addition of title compound; taking haemolymph samples; isolation of digestive cells from digestive gland by method of Lowe (1994)

Results

mean NRR time: ca. 49-63 percent in blood cell lysosoms, ca. 60 percent in digestive cell lysosoms; mean lysosomal latency period: ca. 82-110 percent in digestive sells; significant reduction in lysosomal retention capacity and no difference in latency

Citation

Lowe; Soverchia; Moore

Aquatic Toxicology, 1995 , vol. 33, # 2 p. 105 - 112 Title/Abstract Full Text View citing articles Show Details

Assay Description

Effect : uptake Target : Camellia sasanqua Bioassay : potted plants; transparent acrylic box; vapor of title comp. delivered with air; 25 deg C; relat. humid. 65 percent; light intensity 500 μmol photons/m2/s; uptake and transpiration rate meas.

Citation

Omasa, Kenji; Tobe, Kazuo; Hosomi, Masaaki; Kobayashi, Mizuho

Environmental Science and Technology, 2000 , vol. 34, # 12 p. 2498 - 2500 Title/Abstract Full Text View citing articles Show Details

Assay Description

Effect : uptake Target : Populus nigra Bioassay : potted plants; transparent acrylic box; vapor of title comp. delivered with air; 25 deg C; relat. humid. 65 percent; light intensity 500 μmol photons/m2/s; uptake and transpiration rate meas.

Citation

Omasa, Kenji; Tobe, Kazuo; Hosomi, Masaaki; Kobayashi, Mizuho

Environmental Science and Technology, 2000 , vol. 34, # 12 p. 2498 - 2500 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; examination of Bioassay : in vitro; carbonyl reductase activity determined spectrophotometrically by measuring oxidation rate of NADPH; 80 mM NADPH; potassium phosphate buffer, pH 6.5; 37 deg C

Results

did not exhibit any carbonyl reductase activity

Citation

Nakajin, Shizuo; Tamura, Fumihiro; Takase, Noriko; Toyoshima, Satoshi

Biological and Pharmaceutical Bulletin, 1997 , vol. 20, # 11 p. 1215 - 1218 Title/Abstract Full Text View citing articles Show Details

Assay Description

Bioassay : gravimetric method; humin disk (produced by pressing powders in die): weight 40.8-100.5 g, thickness 0.21-0.61 mm, density 1.35-1.60 g/cm3; flow of gas passed through the liquid title comp. and then mixed with N2; GC-FID analysis

Results

sorption distribution coefficient: Kd = 0.44-0.48 (mg/g)/(mg/l); diffusivity during sorption: Ds = 3.0E-10 - 1.1E-9 cm2/sec (tables, diagrams)

Citation

Shih, Yang-Hsin; Wu, Shian-Chee

Environmental Toxicology and Chemistry, 2002 , vol. 21, # 10 p. 2067 - 2074 Title/Abstract Full Text View citing articles Show Details

Assay Description

Bioassay : title comp. desorption from humin disk (produced by pressing powders in die): weight 40.8-100.5 g, thickness 0.21-0.61 mm, density 1.35-1.60 g/cm3; by purging gas chamber with N2; gravimetric method; GC-FID analysis

Results

desorption diffusivity during desorption: Dd = 3.0E-10 - 1.1E-9 cm2/sec (tables, diagrams)

Citation

Shih, Yang-Hsin; Wu, Shian-Chee

Environmental Toxicology and Chemistry, 2002 , vol. 21, # 10 p. 2067 - 2074 Title/Abstract Full Text View citing articles Show Details

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Assay Description

Results

adsorption adsorption capacity: 12-51 mg/g; effect of preparation conditions (impregnation ratio, activation temperature and time) on adsorption capacity presented; diagrams

Citation

Rio, Sebastien; Faur-Brasquet, Catherine; Coq, Laurence Le; Courcoux, Philippe; Cloirec, Pierre Le

Chemosphere, 2005 , vol. 58, # 4 p. 423 - 437 Title/Abstract Full Text View citing articles Show Details

Effect

Genotoxic

Assay Description

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Morris, Suzanne M.; Manjanatha, Mugimane G.; Shelton, Sharon D.; Domon, Olen E.; McGarrity, Lynda J.; Casciano, Daniel A.

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1996 , vol. 356, # 2 p. 129 - 134 Title/Abstract Full Text View citing articles Show Details

Effect

Behavioural Symptoms

Biological material

Caenorhabditis elegans

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Bioassay : young adult nematodes used; in dH2O; 50-100 nematodes monitored; 6 cycles in 1 run; in each cycle nematodes were exposed to air for 50 sec followed by air from the other bottle for 50 sec computer tracking studies; threshold chemosensitivity determined; average rate of locomotion as a function of time determined

Results

threshold chemosensitivity at 1E-10 M/l; diagram

Citation

Terrill, William F.; Dusenbery, David B.

Journal of Chemical Ecology, 1996 , vol. 22, # 8 p. 1463 - 1475 Title/Abstract Full Text View citing articles Show Details

Effect

Toxic

Biological material

Callosobruchus maculatus

Assay Description

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Target : Salmonella typhimurium TA1535/pSK1002 Bioassay : umu test; positive effect: two-fold induction of umu operon above the background level

Citation

Assay Description

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Bioassay : carbonaceous sorbent prepared from sewage sludge by chemical activation process with sulfuric acid; sludge collected from municipal treatment plant in Nantes-Tougas, France; ca. 20 deg C; room pressure; initial title comp. conc.: 100 mg/l; GC analysis

Bioassay : insect culture kept at 28 deg C, RH: 70 percent, constant red light; bioassays conducted at the same conditions; one- to two-day-old insects; n=15 per chamber fumigation bioassay; mortality assessed

Citation

Don-Pedro, Kio N.

Pesticide Science, 1996 , vol. 46, # 1 p. 79 - 84 Title/Abstract Full Text View citing articles Show Details

Results

effect on cell growth and glycerol dehydrogenase formation by Geotrichum candidum F-541

Citation

Itoh, Nobuya; Umeda, Koichi

Agricultural and Biological Chemistry, 1982 , vol. 46, # 8 p. 2159 - 2162 Title/Abstract Full Text Show Details

Effect

Toxic

Biological material

Aedes albopictus

Assay Description

Bioassay : in vivo; 10 second instar larvae; treatment with aq. solut. of title comp.; at room temperature; under fluorescent lamp illumination; degree of activity was judged by the percent of living larvae

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Citation

Harada, Ken-Ichi; Suomalainen, Mette; Uchida, Hideaki; Masui, Hiroaki; Ohmura, Kuniyo; Kiviranta, Jari; Niku-Paavola, Marja-Leena; Ikemoto, Takaya

Environmental Toxicology, 2000 , vol. 15, # 2 p. 114 - 119 Title/Abstract Full Text View citing articles Show Details

Effect

Mutagenic

Assay Description

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Results

PFU/plate for -/+ S9 (conc., percent): 33/54.3 (0), 39.1/59.2 (0.005), 45/61.2 (0.01), 40.1/66.1 (0.02), 48.2/74.2 (0.039), 46.1/69.1 (0.078), 48.0/63.0 (0.156), 46/72.8 (0.313), 40/67.8 (0.625), 45.1/64.8 (1.25), 46.2/71.6 (2.5), 49.5/87 (5.0), 42.8/90

Citation

Cabrera, Guillermo

Environmental and Molecular Mutagenesis, 2000 , vol. 36, # 3 p. 206 - 220 Title/Abstract Full Text View citing articles Show Details

Results

No influence on mortality of Mosquito Larvae (Culex fatigans), after 24 h at 100 ppm

Citation

Choudhury; Kumar; Das

Journal of the Indian Chemical Society, 1991 , vol. 68, # 1 p. 64 - 65 Title/Abstract Full Text View citing articles Show Details

Effect

Carcinogenic

Biological material

Syrian hamster

Assay Description

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Target : Escherichia coli, strain WP2s (lambda) Bioassay : test strain: lysogenic for phage lambda derived from E. Coli B/r; indicator strain: TH-008 derived from E. Coli C; at 37 deg C; 25 (-S9) and 10 (+S9) replicates; control: without title comp.; PFU: plaque-forming units in vitro; Microscreen prophage-induction assay; in 96-well microtiter plates; with (+)/without (-) S9 mix; conc. of phage determined using indicator strain; plaques counted

Bioassay : substance inducing a reproducible and dose dependent increase in micronucleus frequency regarded as positive Syrian hamster embryo (SHE) micronucleus test in vitro; in DMSO solution; incubated for 18 h; 2000 cells counted microscopically from each coverslip, number of cells with micronuclei was determined

Results

also correlation with literature data for carcinogenicity No effect

Citation

Friedberg; Henning

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1993 , vol. 289, # 1 p. 47 - 53 Title/Abstract Full Text Show Details

Assay Description

Bioassay : prediction of impact on air quality from point emission sources performed using US EPA approved software model SCREEN

Results

dispersion max. predicted conc. of test comp. in ambient air 70 m and 300 m downwind from test sites = 1.34 and 0.25 mg/m3; 1/40th long term exposure limits of UK Health and Safety Authority (LTEL) = 45 mg/m3

Citation

James, Kevin J.; Cherry, Maureen; Stack, Mary A.

Chemosphere, 1995 , vol. 31, # 7 p. 3741 - 3751 Title/Abstract Full Text Show Details

Effect

Toxic

Assay Description

Target : Daphnia galeata mendotae Bioassay : Daphnia collect. from Lake Wingra, Wisconsin, USA in Dec. 1994; ANCOVA single clone CDF-1; pairs of neonates (<36-h old) placed into 30 ml of medium; fed on zooplankton; 20 deg C; 9-h light:15-h dark cycle; developmental effects; fecundity; sex determination

Results

increased daily production of females

Citation

Shurin, Jonathan B.; Dodson, Stanley I.

Environmental Toxicology and Chemistry, 1997 , vol. 16, # 6 p. 1269 - 1276 Title/Abstract Full Text View citing articles Show Details

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Biological material

Oncorhynchus mykiss

Assay Description

Effect : |liver effects Bioassay : water quality: total hardness 260 mg/l CaCO3, pH 7.6, dissolv. oxygen ca. 60 percent yolk-sac fry; stage 33-34; aquar. cont. dechlorin. tap water; 6 deg C; 12:12 h light:dark cycle; semi-static test; sol. changed every day; survival after 30 d; cytological anal. of liver; electron microscope; hepatocyte intracellular structure

Results

no effect on survival; changes in hepatocyte membranes (dilation of interhepatocytic space, form. of intracellul. myelinic figures) between 1 and 7 d of expos.; not persis after 22 d; minor struct. changes in liver nuclei and bile canaliculi

Citation

Biagianti-Risbourg, Sylvie; Vernet, Guy; Boulekbache, Habib

Chemosphere, 1998 , vol. 36, # 9 p. 1911 - 1922 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; examination of Bioassay : eels weigh. 20-30 g; length 16-20 cm; 300-l tanks; flow-through system; declorin. tap water; 20 deg C; pH 7.9; gills; Mg2+-, Na+,K+-ATPases and total ATPase activ.

Citation

Sancho; Ferrando; Andreu

Ecotoxicology and Environmental Safety, 1997 , vol. 38, # 2 p. 132 - 136 Title/Abstract Full Text View citing articles Show Details

Effect

Cytotoxic

Biological material

cells

Assay Description

Effect : protein content Bioassay : NI50=conc. of test comp. required to induce 50 percent reduct. in neutral red uptake in cult. FHM fish cells; PI50=conc. of test comp. required to induce 50 percent reduction in total protein content; PI50 calc. in the abs. of BSO and SDS cell density 6E5 cells in 200 μl complete medium/well; titer plates; 34 deg C; in the pres. or abs. of buthionine sulfoximine (BSO, 0.4 mM) or sodium dodecyl sulfate (SDS, 0.2 mM); protein content meas. fluorim.; endogenous GSH cont.

Results

PI50 GSH content: 29 percent; test sensit. increased in the pres. of BSO 171 mmol/l

Citation

Dierickx, Paul J.

Chemosphere, 1998 , vol. 36, # 6 p. 1263 - 1274 Title/Abstract Full Text View citing articles Show Details

Effect

Phytotoxic

Biological material

carrot

Assay Description

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Bioassay : DNA (Ri T-DNA)-transformed carrot roots; M-medium; inoculated with VAM fungus Glomus intraradices; in dark; 27 deg C; root growth; biomass and VAM colonization ( percent)

Results

no effect on Ri T-DNA-transformed roots and root biomass below 50000 ppm of test comp.; root elongation suppress. and root dry weight signif. reduc. at 50000 ppm; VAM development severely reduced at 50000 ppm

Citation

Wan, Michael T.; Rahe, James E.; Watts, Ronald G.

Environmental Toxicology and Chemistry, 1998 , vol. 17, # 7 p. 1421 - 1428 Title/Abstract Full Text View citing articles Show Details

Effect

Phytotoxic

Biological material

maize

Assay

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Description

Bioassay : growth exper.; 72-96-h old maize seedlings; sized accord. to length of primary root; incub. on circles of filter paper moisten. with 3 ml of solution; contain. in petri dishes

Results

root growth stimulated at con. of test comp. up to 1E-4 M; inhibited at higher conc.

Citation

Morre

Human and Experimental Toxicology, 1998 , vol. 17, # 5 p. 272 - 277 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; induction of Bioassay : isolated hepatocytes electroporated with each of individual enhancer-TKCAT reporter plasmids and pSVβgal control plasmid; CAT: chloramphenicol acetyltransferase; positive, negative control: TCPOBOP, 1,4-bis(2-(3-chloro-pyridyloxy))benzene cells treated with title comp. for 24 h, then heat-treated for 20 min and assayed for CAT activity; RNAs extracted for Northern blot analysis

Results

title comp. induced CAT activity and CYP2B10 mRNA

Citation

Honkakoski, Paavo; Moore, Rick; Washburn, Kimberly A.; Negishi, Masahiko

Molecular Pharmacology, 1998 , vol. 53, # 4 p. 597 - 601 Title/Abstract Full Text View citing articles Show Details

Biological material

Rattus norvegicus

Assay Description

Effect : |biotransformation Bioassay : control: pretreatment with vehicle, gas-phase title comp. injection rats pretreated with 5 mmol/l title comp. in combination with 5 mmol/kg styrene for 3 days; decapitated; liver S9 prepared; gas-phase title comp. with/without styrene injected to the vial; after 30-min incubation, liver S9 conc. of title comp. measured

Results

elimination rate of title comp. was higher in pretreated single exposure group compared to control (figure)

Citation

Mortensen, Bjarte; Osvoll, Peter O.; Woldbaek, Torill; Zahlsen, Kolbjorn; Eide, Ingvar; Nilsen, Odd G.

Pharmacology and Toxicology, 1998 , vol. 83, # 2 p. 49 - 56 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; induction of Bioassay : pp60src-derived substrate: Gly-Ser-Ser-Lys-Ser-Lys-Pro-Lys-Arg; hNMT: human N-myristoyltransferase; further investigation on the mechanism with infrared spectroscopy title comp. was incubated in reaction mixture containing 40 mmol/l Tris-HCl (pH 7.4), 0.5 mmol/l EGTA, 1 percent Triton X-100, 1 μmol/l <3H>myristoyl-CoA, 500 μmol/l pp60src-derived substrate and hNMT for 30 min at 30 deg C; radioactivity was measured

Results

title comp. induced a ca. 20-fold increase of hNMT activity

Citation

Pasha, Mohammed Khysar; Dimmock, Jonathan R.; Hollenberg, Morley D.; Sharma, Rajendra K.

Biochemical Pharmacology, 2002 , vol. 64, # 10 p. 1461 - 1467 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; induction of Bioassay : Ser-free cAMP-dependent protein kinase-derived substrate: Gly-Asn-Ala-Ala-Ala-Ala-Lys-Lys-Arg-Arg; hNMT: human N-myristoyltransferase title comp. was incubated in reaction mixture containing 40 mmol/l Tris-HCl (pH 7.4), 0.5 mmol/l EGTA, 1 percent Triton X-100, 1 μmol/l <3H>myristoyl-CoA, 500 μmol/l Ser-free peptide substrate and hNMT for 30 min at 30 deg C; radioactivity was measured

Results

title comp. induced a ca. 2.5-fold increase in hNMT activity

Citation

Pasha, Mohammed Khysar; Dimmock, Jonathan R.; Hollenberg, Morley D.; Sharma, Rajendra K.

Biochemical Pharmacology, 2002 , vol. 64, # 10 p. 1461 - 1467 Title/Abstract Full Text View citing articles Show Details

Assay Description

Effect : cell fixation Target : cells expressing cystic fibrosis transmembrane conduction regulator with phenylalanine deletion Δ-F508-CFTR protein

Bioassay : Figure 5: Differing regimes of fixation for cells affect the read out of the CFTR corrector screen assay. All fixations were performed at 4&deg;C. The time of fixation allotted varied depending on the type of fixation with Methanol, Acetone andMethanol/Acetone all being carried out for 3-5 minutes;

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Results

~ 40% difference in fluorescence between cells grown at 27C and 37C; for more details see fig. 5

Citation

THOMAS, David, Y.; HANRAHAN, John; CARLILE, Graeme; ROBERT, Renaud

Patent: WO2008/138123 A1, 2008 ; Title/Abstract Full Text Show Details

Biological material

cells

Assay Description

Effect : cell fixation Bioassay : Figure 5: Differing regimes of fixation for cells affect the read out of the CFTR corrector screen assay. All fixations were performed at 4&deg;C. The time of fixation allotted varied depending on the type of fixation with Methanol, Acetone andMethanol/Acetone all being carried out for 3-5 minutes;

Results

~ 20% difference in fluorescence between cells grown at 27C and 37C; for more details see fig. 5

Citation

THOMAS, David, Y.; HANRAHAN, John; CARLILE, Graeme; ROBERT, Renaud

Patent: WO2008/138123 A1, 2008 ; Title/Abstract Full Text Show Details

Results

effect on susceptibility of yeast cells to Zymolase and antigenicity

Citation

Tamai, Youichi; Nakashima, Takahiro; Takakuwa, Masayoshi

Agricultural and Biological Chemistry, 1980 , vol. 44, # 11 p. 2527 - 2532 Title/Abstract Full Text Show Details

Results

insecticidal activity against cockroaches - K. D. = 40 h at conc. of 0.5 or 0.1percent; no antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Bacillus pumilus

Citation

Gupta; Misra

Agricultural and Biological Chemistry, 1980 , vol. 44, # 5 p. 1009 - 1013 Title/Abstract Full Text View citing articles Show Details

Results

inhibition of the O-deethylation of 7-ethoxycoumarin catalysed by murine hepatic microsomes (male NMRI mice) is 47percent to the control at a concentration of 1percent; IC 50 is 50 mM

Citation

Tegtmeier; Wolfel; Sommerlad; Legrum

Pharmazie, 1995 , vol. 50, # 1 p. 73 - 74 Title/Abstract Full Text View citing articles Show Details

Results

calculated minimum nerve-blocking concentration (MBC), log MBC 2.48, 2.89

Citation

Abe; Kamaya; Ueda

Journal of Pharmaceutical Sciences, 1988 , vol. 77, # 2 p. 166 - 168 Title/Abstract Full Text View citing articles Show Details

Effect

Insecticidal

Assay Description

Target : eastern subterranian termite Bioassay : Test No.1. Choice Feeding Bait Test, Halofenozide + Hexaflumuron. A paired choice feeding test was conducted to compare feeding response and resultant mortality caused by various combinations of technical grade halofenozide and hexaflumuron treated on filter paper (acetone carrier). The test apparatus

Results

82 - 87.5% surviving potential area of application: agro

Citation

UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.; DOW AGROSCIENCES LLC

Patent: WO2005/79572 A1, 2005 ; Title/Abstract Full Text Show Details

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Assay Description

Effect : filter paper; antifeeding protection of Target : Coptotermes formosanus, termite worker Bioassay : Test Example 2 An acetone solution (1 ml) containing 10 mg of the test compound was dropped on filter paper (33 mm in diameter, Milk sediment disk 1026 produced by Toyo Roshi K.K.) and dried at room temperature overnight. The filter paper was set in a white plastic cup (35 mm in diameter) having one

Results

The decreasing ratio Test compound of the weight (%) Reference 7.63 potential area of application: agro

Citation

SUMITOMO CHEMICAL COMPANY, LIMITED

Patent: US2006/9519 A1, 2006 ; Title/Abstract Full Text Show Details

Assay Description

Effect : wooden material; antifeeding protection of Target : Coptotermes formosanus, termite worker Bioassay : Test Example 1 A designated amount (10 mg or 100 mg) of octyl gallate was dissolved in 0.3 ml of acetone and uniformly spread on a piece of Japanese black pine wood (1 cm*1 cm*2 cm) with pipette. The wood was allowed to stand overnight at room temperature, dried at 60 C. in a thermostat for 3 days,

Results

The decreasing ratio of the weight (%) Reference 5.9 potential area of application: agro

Citation

SUMITOMO CHEMICAL COMPANY, LIMITED

Patent: US2006/9519 A1, 2006 ; Title/Abstract Full Text Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; examination of Bioassay : substrate specificity study; reduction of 20 mM title comp. by test enzyme with 0.2 μmol NADPH as cofactor, 50 μmol potassium phosphate buffer (pH 6.5)

Results

enzyme relative activity 0 percent, compared with (rel. act. percent): ethyl 4-chloroacetoacetate 100, methyl 4-chloroacetoacetate 66.3, 2,3-butanedione 4.2, 2,3-pentanedione 44.2, methylglyoxal 1.8, m-nitrobenzaldehyde 0.4; title comp. was no substrate

Citation

Yamamoto, Hiroaki; Kimoto, Norihiro; Matsuyama, Akinobu; Kobayashi, Yoshinori

Bioscience, biotechnology, and biochemistry, 2002 , vol. 66, # 8 p. 1775 - 1778 Title/Abstract Full Text View citing articles Show Details

Effect

Reproductive Effect

Assay Description

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Target : Daphnia magna Strauss Bioassay : < 24 h old neonates; glass beakers contain. H-H COMBO medium; 16:8 or 8:16 h light:dark cycle; 20 deg C; high and low food conditions; total numbers of broods, neonates, females and males determ.; sex ratio of offsprings also

Results

total numbers of broods, young, male and females signif. increased under 16:8 h light:dark and low food conditions; no males at high food level; increased sex ratio under normal light conditions; parthenogenetic reproduction at high food level

Citation

Zhang; Baer

Environmental Pollution, 2000 , vol. 110, # 3 p. 425 - 430 Title/Abstract Full Text Show Details

Results

at 10percent no effect on andien-β synthase, decrease of C-17-hydroxy/lyase activity in Yorkshire-Landrace cross boar testicular microsomes

Citation

Meadus; Squires

Steroids, 1995 , vol. 60, # 5 p. 395 - 400 Title/Abstract Full Text Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; induction of Bioassay : chlorzoxazone 6-hydroxylase activity by formation of 6-hydroxychlorzoxazone determined by reversed-phase HPLC; immunohistochemical staining by indirect peroxidaseantiperoxidase method; CYP2E1 by Western blot analysis mice (30-40 g) exposed to acetone (1 percent v/v) in drinking water; microsomes prepared from colons; tissue sections fixed in 1 percent paraformaldehyde and incubated with anti-rat CYP2E1 polyclonal antibody

Results

chlorzoxazone 6-hydroxylase activity increased 2.5-fold exposed to title compound compared to control; immunoreactivity localized within cytoplasm of surface epithelial cells of proximal colon; up to 2-fold induction of CYP2E1

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Citation

Park; Liu; Averill Jr.; Jackman; Rosenberg

Pharmacology, 1995 , vol. 50, # 6 p. 339 - 347 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; induction of Bioassay : chlorzoxazone 6-hydroxylase activity by formation of 6-hydroxychlorzoxazone determined by reversed-phase HPLC; immunohistochemical staining by indirect peroxidaseantiperoxidase method; CYP2E1 by Western blot analysis mice (30-40 g) exposed to acetone (1 percent v/v) in drinking water; microsomes prepared from livers; tissue sections fixed in 1 percent paraformaldehyde and incubated with anti-rat CYP2E1 polyclonal antibody

Results

chlorzoxazone 6-hydroxylase activity increased 2.8-fold exposed to title compound compared to control; up to 1.5-fold inductuin of CYP2E1

Citation

Park; Liu; Averill Jr.; Jackman; Rosenberg

Pharmacology, 1995 , vol. 50, # 6 p. 339 - 347 Title/Abstract Full Text View citing articles Show Details

Assay Description

Bioassay : volatilization during routine use of household showers under normal conditions investigated; water temp. 21-36 deg C; liquid flow rate 6.1-9.1 L/min; enclosed chamber; 5 tracers added to water; 8-min experiments with liquid-phase and gas sampling

Results

volatilization mass transfer coefficient KLA: 1.4-3.7 L/min; stripping efficiency: 6.3-16 percent

Citation

Moya, Jacqueline; Howard-Reed, Cynthia; Corsi, Richard L.

Environmental Science and Technology, 1999 , vol. 33, # 14 p. 2321 - 2327 Title/Abstract Full Text View citing articles Show Details

Assay Description

Bioassay : Kenmore dishwasher; tap water spiked with multi-tracer stock solution contain. title comp.; rinse and wash cycles; empty and full loading patterns; water temp. 38-55 deg C; effect of ventil. rate; liquid and headspace samples anal. with GC-FID

Results

release chemical stripping efficiency 18-55 percent; mass transfer coefficient KLA=1.7-9.4 l/min

Citation

Howard-Reed, Cynthia; Corsi, Richard L.; Moya, Jacqueline

Environmental Science and Technology, 1999 , vol. 33, # 13 p. 2266 - 2272 Title/Abstract Full Text View citing articles Show Details

Assay Description

Bioassay : snow from Central Swiss Alp collected on January 10, 2003; 46 deg 37' 02" N, 8 deg 35' 38" E; altitude: ca. 2278 m above sea level; sorption coefficient determined from retention volume; -6.8 deg C; inverse gas chromatography analysis

Results

sorption log Ki snow surface/air (m3/m2): -3.73; Ki snow surface/air: air/snow surface sorption coefficient

Citation

Roth, Christine M.; Goss, Kai-Uwe; Schwarzenbach, Rene P.

Environmental Science and Technology, 2004 , vol. 38, # 15 p. 4078 - 4084 Title/Abstract Full Text View citing articles Show Details

Assay Description

Bioassay : air stream containing aq. title comp. (1600 ppm) passed radially and axially into cross-flow rotating packed bed with water at gas, liquid rates 52.7 and 0.4 l/min resp.; 500-1600 rpm rotational speed; GC-FID; mass transfer coefficients (KGa) determ.

Results

absorption title comp. mass transfer coefficients (KGa): ca. 1.5, 2.0, 2.8, and 3.3 s-1; conc. of title comp. in gas stream decrease in axial direction and conc. in liquid stream increase in radial direction; title comp. removal efficiencies:

Citation

Chen, Yu-Shao; Hsu, Yi-Chun; Lin, Chia-Chang; Tai, Clifford Yi-Der; Liu, Hwai-Shen

Environmental Science and Technology, 2008 , vol. 42, # 7 p. 2631 - 2636 Title/Abstract Full Text View citing articles Show Details

Assay

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Description

Bioassay : air stream containing aqueous title comp. passed into cross-flow rotating packed bed with water at 26.7-52.7 l/min gas flow rates, 0.7 l/min liquid flow rate and at rotational speeds 500-1600 rpm; GC-FID; mass transfer coefficients (KGa) determined

Results

absorption title comp. mass transfer coefficients (KGa): ca. 1.2-ca. 3.6 s-1; title comp. mass transfer coefficients increased with increasing gas flow rates at different rotational speeds; title comp. removal efficiencies: 55-98%; figure

Citation

Chen, Yu-Shao; Hsu, Yi-Chun; Lin, Chia-Chang; Tai, Clifford Yi-Der; Liu, Hwai-Shen

Environmental Science and Technology, 2008 , vol. 42, # 7 p. 2631 - 2636 Title/Abstract Full Text View citing articles Show Details

Assay Description

Bioassay : air stream containing aqueous title comp. passed into cross-flow rotating packed bed with water at 37.3 l/min gas flow rate, 0.2-0.7 l/min liquid flow rate and at rotational speeds 500-1600 rpm; GC-FID; mass transfer coefficients (KGa) determined

Results

absorption title comp. mass transfer coefficients (KGa): ca. 0.8-ca. 3 s-1; title comp. mass transfer coefficients increased with increasing liquid flow rates at different rotational speeds; title comp. removal efficiencies: 55-98%; figure

Citation

Chen, Yu-Shao; Hsu, Yi-Chun; Lin, Chia-Chang; Tai, Clifford Yi-Der; Liu, Hwai-Shen

Environmental Science and Technology, 2008 , vol. 42, # 7 p. 2631 - 2636 Title/Abstract Full Text View citing articles Show Details

Assay Description

Bioassay : air stream containing aqueous title comp. passed into cross-flow rotating packed bed with water at 52.7 l/min gas flow rate, 0.2-0.7 l/min liquid flow rates and rotational speeds 500-1600 rpm; GC-FID; mass transfer coefficients (KGa) determined

Results

absorption title comp. mass transfer coefficients (KGa): ca. 0.9-ca. 3.6 s-1; title comp. mass transfer coefficients increased with increasing rotational speed at different liquid flow rates; title comp. removal efficiencies: 55-98%; figure

Citation

Chen, Yu-Shao; Hsu, Yi-Chun; Lin, Chia-Chang; Tai, Clifford Yi-Der; Liu, Hwai-Shen

Environmental Science and Technology, 2008 , vol. 42, # 7 p. 2631 - 2636 Title/Abstract Full Text View citing articles Show Details

Assay Description

Bioassay : dynamic flow-through technique; IGC-FID; title comp. injected onto the column packed with humic acid (<2 μm thick) coated glass beads; equilibrated at least 48 h; <0.01 percent-98 percent relative humidity; 15 deg C; relative humidity effect on partition equilibrium

Results

partition Leonardite humic acid/air partition coefficient, KHA,air = 1.20E3 - 2.30E3 l/kgHA; relative humidity affected experimental partition coefficient by up to a factor of 3; diagram

Citation

Niederer, Christian; Goss, Kai-Uwe; Schwarzenbach, Rene P.

Environmental Science and Technology, 2006 , vol. 40, # 17 p. 5368 - 5373 Title/Abstract Full Text View citing articles Show Details

Assay Description

Bioassay : dynamic flow-through technique; IGC-FID; title comp. injected onto the column packed with humic acid (<2 μm thick) coated glass beads; equilibrated for 80 d; 98 percent relative humidity; 5-75 deg C; temperature dependence of partition equilibrium studied

Results

partition Leonardite humic acid/air partition coefficient, KHA,air = 4.76E2 - 1.87E3 l/kgHA; no glass transitions below 75 deg C that had an effect on the sorption properties of humic acid as indicated by linear van't Hoff plot

Citation

Niederer, Christian; Goss, Kai-Uwe; Schwarzenbach, Rene P.

Environmental Science and Technology, 2006 , vol. 40, # 17 p. 5368 - 5373 Title/Abstract Full Text View citing articles Show Details

Results

determination of acetone in human urine samples by self-prepared semiconductor gas sensors

Citation

Reichel; Seyffarth; Guth; Mobius; Gockeritz

Pharmazie, 1989 , vol. 44, # 10 p. 698 - 702 Title/Abstract Full Text View citing articles Show Details

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Assay Description

Bioassay : cuticular membranes isol. from mature tomato fruits (Lycopersicon esculentum Mill. cultivar Vendor); static headspace GC method; glass vials; 25 deg C; 3 h; exper. with relat. humid. 26-76 percent also

Results

partition air-cuticular matrix membranes partition coefficient KMXa=250

Citation

Welke, Birgit; Ettlinger, Karin; Riederer, Markus

Environmental Science and Technology, 1998 , vol. 32, # 8 p. 1099 - 1104 Title/Abstract Full Text View citing articles Show Details

Assay Description

Bioassay : static headspace GC method

Results

partition air-water partition coefficient Kaw=4.2E-3

Citation

Welke, Birgit; Ettlinger, Karin; Riederer, Markus

Environmental Science and Technology, 1998 , vol. 32, # 8 p. 1099 - 1104 Title/Abstract Full Text View citing articles Show Details

Results

frog tadpoles narcosis potency log 1/c = 0.61

Citation

Kier

Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 7 p. 807 - 810 Title/Abstract Full Text View citing articles Show Details

Assay Description

Effect : protein; expression of Target : activated sludge culture Bioassay : sludge culture from publicly owned treatment works (POTWs), Radford, VA; control: unstressed culture; GroEL: heat shock protein, Hsp60; compared to effect of heat shock (43 deg C) batch experiment; activated sludge culture incubated with title comp. for 30 min; at room temp., under air aeration; expression of GroEL measured by SDS-PAGE and Western blot analysis using primary anti-GroEL antibody (dilution 1:5000)

Results

GroEL rapidly induced by title comp.; effect lower than that of heat shock; mass response ratio, integrated density value/μg protein loaded: ca. 9.9E4 (control), 1.57E5 (heat shock), 1.25E5 (title comp.); graph

Citation

Bott; Love

Water Research, 2001 , vol. 35, # 1 p. 91 - 100 Title/Abstract Full Text View citing articles Show Details

Results

in vitro inhibitory activity on commercial yeast AlDH in a primary reaction mix measured by the formation of NADH (nmol/min, 1st value) and calculated inhibition (percent, 2nd value): 14.0, 0.5

Citation

Nagasawa; Elberling; DeMaster; Shirota

Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1335 - 1340 Title/Abstract Full Text Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; induction of Bioassay : compared with control DMSO treated eggs and isoniazid-treated rat (12 μg of protein loaded) in isolated microsomes; from fertile brown chicken eggs; treated title comp. on incubation day 17; removed liver 24 h after administration; performed immunoblot analysis with sheep anti-CYP1E1 followed by peroxidase-linked donkey anti-sheep IgG

Citation

Machala, Miroslav; Nezveda, Karel; Irizar, Amaia; Bu-Abbas, Ali; Ioannides, Costas

Archives of Toxicology, 1996 , vol. 71, # 1-2 p. 57 - 63 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; induction of Bioassay : compared with control DMSO treated eggs in isolated microsomes, from 6-9 livers; from fertile brown chicken eggs; treated title comp. on incubation day 17; removed liver 24 h after administration; assayed activities p-nitrophenol hydroxylase by Reinke, erythromycin N-demethylase by Wrighton

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Results

title comp. signif. induced p-nitrophenol hydroxylase but not affect on erythromycin N-demethylase activities; p-nitrophenol hydroxylase, pmol/min/mg protein: 92 vs. 73 in control; erythromycin N-demethylase, nmol/min/mg protein: 0.23 vs 0.24 in control

Citation

Machala, Miroslav; Nezveda, Karel; Irizar, Amaia; Bu-Abbas, Ali; Ioannides, Costas

Archives of Toxicology, 1996 , vol. 71, # 1-2 p. 57 - 63 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; inhib. of Bioassay : experiments also performed with 3-methylcholanthrene pretreated rats (30 mg/kg, i.p., daily for five consecutive days) blood lymphocyte protein were incubated for 20 min at 37 deg C with title comp., NADPH, bovine serum albumin, 7-ethoxyresorufin and sodium phosphate buffer; 7-ethoxyresorufin-O-deethylase activity was determined with enzyme assay

Citation

Dey, Aparajita; Parmar, Devendra; Dayal, Monika; Dhawan, Alok; Seth, Prahlad K.

Life Sciences, 2001 , vol. 69, # 4 p. 383 - 393 Title/Abstract Full Text View citing articles Show Details

Assay Description

Effect : |receptor blocking agent Target : bovine adrenal chromaffin cells Bioassay : nonspecific binding in presence of 1 μmol/l unlabeled insulin; IR: insulin receptors 60-62 h culture cells treated with title comp. for up to 48 h, incubated at 4 deg C for 6 h with <125I>-insulin, then radioactivity counted; Western blot analysis of IR and IR precursor molecule levels

Citation

Yokoo, Hiroki; Saitoh, Tomokazu; Shiraishi, Seiji; Yanagita, Toshihiko; Sugano, Takashi; Minami, Shin-Ichi; Kobayashi, Hideyuki; Wada, Akihiko

Journal of Pharmacology and Experimental Therapeutics, 2003 , vol. 304, # 3 p. 994 - 1002 Title/Abstract Full Text View citing articles Show Details

Biological material

Anura muscle cell

Assay Description

Difference between observed and calculated concentration value of compound required for inhibition of narcotic action on frog muscle

Results

Delta log (I/C) not calculated

Citation

Hansch; Anderson

Journal of medicinal chemistry, 1967 , vol. 10, # 5 p. 745 - 753 Title/Abstract Full Text Show Details

Biological material

Anuraheart

Assay Description

Difference between observed and calculated concentration value of compound required for inhibition of narcotic action on frog heart

Results

Delta log (I/C) not calculated

Citation

Hansch; Anderson

Journal of medicinal chemistry, 1967 , vol. 10, # 5 p. 745 - 753 Title/Abstract Full Text Show Details

Assay Description

Tadpole narcotic activity of the compound was determined

Results

log 1/Cnar not calculated

Citation

Agrawal, Vijay K.; Chaturvedi, Sanjeev; Abraham, Michael H.; Khadikar, Padmakar V.

Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 20 p. 4523 - 4533 Title/Abstract Full Text View citing articles Show Details

Biological material

Salmonella enterica subsp. enterica serovar Typhimurium TA 100

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Assay Description

Mutagenic effect of the compound against salmonella typhimurium TA 100 when added with an amount 500 ug per plate

Results

Mutagenicity not calculated

Citation

Tsutomu YAMAGUCHI

Agricultural and biological chemistry, 1982 , vol. 46, # 3 p. 849 - 851 Title/Abstract Full Text Show Details

Biological material

rabbit

Assay Description

Eye irritation potential of compound was evaluated using the Draize in vivo rabbit eye irritation test measured as molar adjusted eye score (MES)

Results

Molar adjusted eye score not calculated

Citation

Stiefl, Nikolaus; Baumann, Knut

Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1390 - 1407 Title/Abstract Full Text View citing articles Show Details

Assay Description

Minimum concentration of the compound (anesthetic) required to completely block the excitability at the surface

Results

log MBC not calculated

Citation

S. P. GUPTA

Chemical reviews, 1991 , vol. 91, # 6 p. 1109 - 1119 Title/Abstract Full Text Show Details

Effect

Antimicrobial

Biological material

Legionella pneumophila CORBY

Assay Description

Minimum inhibitory concentration of compound against Legionella pneumophila Corby was determined

Results

- = no inhibition

Citation

Journal of Natural Products, 2011 , vol. 74, # 3 p. 365 - 373 Title/Abstract Full Text View citing articles Show Details

Biological material

Anura

Assay Description

Effect of the compound on inhibition of frog (Rana pipiens) muscle activity

Citation

Wilson; Famini

Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1668 - 1674 Title/Abstract Full Text View citing articles Show Details

Effect

Antimicrobial

Biological material

Staphylococcus aureus ATCC 11632

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Assay Description

Minimum inhibitory concentration of the compound against growth of Staphylococcus aureus ATCC 11632 upon incubation at 37 degree C for 24 hours

Results

(-) = Resistant

Citation

Sahu, Pramod K.; Sahu, Praveen K.; Gupta; Thavaselvam; Agarwal

European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 366 - 378 Title/Abstract Full Text View citing articles Show Details

Effect

Antimicrobial

Biological material

Providencia rettgeri

Assay Description

Minimum inhibitory concentration of the compound against growth of DRDE strain Providencia rettgeri upon incubation at 37 degree C for 24 hours

Results

(-) = Resistant

Citation

Sahu, Pramod K.; Sahu, Praveen K.; Gupta; Thavaselvam; Agarwal

European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 366 - 378 Title/Abstract Full Text View citing articles Show Details

Effect

Antimicrobial

Biological material

Pseudomonas aeruginosa ATCC 23564

Assay Description

Minimum inhibitory concentration of the compound against growth of Pseudomonas aeruginosa ATCC 23564 upon incubation at 37 degree C for 24 hours

Results

(-) = Resistant

Citation

Sahu, Pramod K.; Sahu, Praveen K.; Gupta; Thavaselvam; Agarwal

European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 366 - 378 Title/Abstract Full Text View citing articles Show Details

Biological material

Aspergillus niger

Assay Description

Minimum inhibitory concentration of the compound against growth of Aspergillus niger upon incubation at 28 degree C for 72 hours

Results

No activity

Citation

Sahu, Pramod K.; Sahu, Praveen K.; Gupta; Thavaselvam; Agarwal

European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 366 - 378 Title/Abstract Full Text View citing articles Show Details

Effect

Antimicrobial

Biological material

Salmonella enterica subsp. enterica serovar Typhi ATCC 15499

Assay Description

Minimum inhibitory concentration of the compound against growth of Salmonella typhi ATCC 15499 upon incubation at 37 degree C for 24 hours

Results

(-) = Resistant

Citation

Sahu, Pramod K.; Sahu, Praveen K.; Gupta; Thavaselvam; Agarwal

European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 366 - 378 Title/Abstract Full Text View citing articles Show Details

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Biological material

Aspergillus fumigatus

Assay Description

Minimum inhibitory concentration of the compound against growth of Aspergillus fumigatus upon incubation at 28 degree C for 72 hours

Results

No activity

Citation

Sahu, Pramod K.; Sahu, Praveen K.; Gupta; Thavaselvam; Agarwal

European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 366 - 378 Title/Abstract Full Text View citing articles Show Details

Biological material

Aspergillus flavus

Assay Description

Minimum inhibitory concentration of the compound against growth of Aspergillus flavus upon incubation at 28 degree C for 72 hours

Results

No activity

Citation

Sahu, Pramod K.; Sahu, Praveen K.; Gupta; Thavaselvam; Agarwal

European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 366 - 378 Title/Abstract Full Text View citing articles Show Details

Effect

Antimicrobial

Biological material

Escherichia coli ATCC 35218

Assay Description

Minimum inhibitory concentration of the compound against growth of Escherichia coli ATCC 35218 upon incubation at 37 degree C for 24 hours

Results

(-) = Resistant

Citation

Sahu, Pramod K.; Sahu, Praveen K.; Gupta; Thavaselvam; Agarwal

European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 366 - 378 Title/Abstract Full Text View citing articles Show Details

Effect

Antimicrobial

Biological material

Bacillus cereus MTCC 7350

Assay Description

Minimum inhibitory concentration of the compound against growth of Bacillus cereus MTCC 7350 upon incubation at 37 degree C for 24 hours

Results

(-) = Resistant

Citation

Sahu, Pramod K.; Sahu, Praveen K.; Gupta; Thavaselvam; Agarwal

European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 366 - 378 Title/Abstract Full Text View citing articles Show Details

Effect

Antifeedant

Biological material

Spodoptera exigua

Assay Description

Effective concentration of the compound against Spodoptera exigua (Beet armyworm) after 24 hrs feeding on Brassica chinensis leaf disks; positive control (1 azadirachtin) = 2.7 ug/cm2

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Citation

Jing, Shu-Xi; Luo, Shi-Hong; Li, Chun-Huan; Hua, Juan; Wang, Yan-Li; Niu, Xue-Mei; Li, Xiao-Nian; Liu, Yan; Huang, Chun-Shuai; Wang, Ying; Li, Sheng-Hong

Journal of Natural Products, 2014 , vol. 77, # 4 p. 882 - 893 Title/Abstract Full Text View citing articles Show Details

Target

carbonyl reductase (NADPH):Wild

Assay Description

Activity of the compound against Carbonyl reductase

Results

Not Published

Citation

Kaneka Corporation

Patent: US7794993 B2, 2010 ; Title/Abstract Full Text Show Details

Target

carbonyl reductase (NADPH):Wild

Assay Description

Activity of the compound against Carbonyl reductase

Results

Not Published

Citation

SOUICHI MORIKAWA; NORIYUKI KIZAKI; MIHO YANO; MASAHIRO FUNAKI; TERUAKI TAKESUE; YOSHIHIKO YASOHARA; TAKAHISA NAKAI; MICHIHIKO KATAOKA; SAKAYU SHIMIZU

Patent: US2010/317075 A1, 2010 ; Title/Abstract Full Text Show Details

Effect

Antibiotic

Biological material

pseudoxanthomonas mexicana p32 strain

Citation

SC Euro Envirotech SRL; Niculae, Gheorghe; Oancea, Florin; Rusen, Rodica; Doni, Mihaela; Raut, Iuliana; Calin, Mariana; Jecu, Maria-Luiza

Patent: EP2738267 B1, 2016 ; Title/Abstract Full Text Show Details

In vivo: Animal Model (82) Quantitative Results pX

Parameter

Value (qual)

Value (quant)

Unit

Action on Target

Animal Model

Biological Species

Route of administration

LD50

5800

mg/kg

Rattus norvegicus

Dose

Dosing regimen

Effect

Reference (expand all/collapse all)

oral administration

Toxic

Patent: US6642378 B1, ...

Title/Abstract Full Text Show Details

inhalational administration

Toxic

Bulletin of Environmenta...

Title/Abstract Full Text View citing articles Show Details

Antibioticos S.p.A.

Patent: US6642378 B1, 2003 ; Title/Abstract Full Text Show Details

4.04

LC50

5.252 13.241

mg/L

Lello; Nieri

Bulletin of Environmental Contamination and Toxicology, 1999 , vol. 63, # 5 p. 660 - 664 Title/Abstract Full Text View citing articles Show Details

MEIJI SEIKA PHARMA CO., LTD.; HORIKOSHI, Ryo; MITOMI, Masaaki

Patent: US2015/57288 A1, 2015 ; Title/Abstract Full Text Show Details

Apis mellifera

topical administration

Mortality

Patent: US2015/57288 A...

Title/Abstract Full Text Show Details

Apis mellifera

topical administration

Mortality

Patent: US2015/57288 A...

Title/Abstract Full Text Show Details

monomorium pharaonis

Repellent

Patent: US2014/323561 ...

Title/Abstract Full Text Show Details

monomorium pharaonis

Repellent

Patent: US2014/323561 ...

Title/Abstract Full Text Show Details

monomorium pharaonis

Repellent

Patent: US2014/323561 ...

Title/Abstract Full Text Show Details

NMRI mouse

topical administration

Repeated

Patent: WO2015/28788 A...

Title/Abstract Full Text Show Details

Callosobruchus maculatus

Insecticidal

Chemistry and Biodiversi...

Title/Abstract Full Text View citing articles Show Details

MEIJI SEIKA PHARMA CO., LTD.; HORIKOSHI, Ryo; MITOMI, Masaaki

Patent: US2015/57288 A1, 2015 ; Title/Abstract Full Text Show Details

Bedoukian Research, Inc.; Bedoukian, Robert H.

Patent: US2014/323561 A1, 2014 ; Title/Abstract Full Text Show Details

Bedoukian Research, Inc.; Bedoukian, Robert H.

Patent: US2014/323561 A1, 2014 ; Title/Abstract Full Text Show Details

Bedoukian Research, Inc.; Bedoukian, Robert H.

Patent: US2014/323561 A1, 2014 ; Title/Abstract Full Text Show Details

Number

21.89

no unit

GILLOTEAUX, Jacques

Patent: WO2015/28788 A1, 2015 ; Title/Abstract Full Text Show Details

Number

91.92

no unit

Babarinde, Samuel Adelani; Pitan, Olufemi Olutoyin Richard; Olatunde, Ganiyu Olatunji; Ajala, Michael Oluwole

Chemistry and Biodiversity, 2017 , vol. 14, # 6 art. no. E1600418 Title/Abstract Full Text View citing articles Show Details

Number

51.56

no unit

Callosobruchus maculatus

Insecticidal

Chemistry and Biodiversi...

Title/Abstract Full Text View citing articles Show Details

Babarinde, Samuel Adelani; Pitan, Olufemi Olutoyin Richard; Olatunde, Ganiyu Olatunji; Ajala, Michael Oluwole

Chemistry and Biodiversity, 2017 , vol. 14, # 6 art. no. E1600418 Title/Abstract Full Text View citing articles Show Details

47.54

Callosobruchus maculatus

Insecticidal

Chemistry and Biodiversi...

Title/Abstract Full Text View citing articles Show Details

Babarinde, Samuel Adelani; Pitan, Olufemi Olutoyin Richard; Olatunde, Ganiyu Olatunji; Ajala, Michael Oluwole

Chemistry and Biodiversity, 2017 , vol. 14, # 6 art. no. E1600418 Title/Abstract Full Text View citing articles Show Details

52.85

experimental infection

cowpea

Insecticidal

Chemistry and Biodiversi...

Title/Abstract Full Text View citing articles Show Details

Babarinde, Samuel Adelani; Pitan, Olufemi Olutoyin Richard; Olatunde, Ganiyu Olatunji; Ajala, Michael Oluwole

Chemistry and Biodiversity, 2017 , vol. 14, # 6 art. no. E1600418 Title/Abstract Full Text View citing articles Show Details

% Inhibition

experimental infection

cowpea

Insecticidal

Chemistry and Biodiversi...

Title/Abstract Full Text View citing articles Show Details

Babarinde, Samuel Adelani; Pitan, Olufemi Olutoyin Richard; Olatunde, Ganiyu Olatunji; Ajala, Michael Oluwole

Chemistry and Biodiversity, 2017 , vol. 14, # 6 art. no. E1600418 Title/Abstract Full Text View citing articles Show Details

Qualitative Information 1 of 69

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Assay Description

Effect : |metabolic Target : SPF Wistar rat Bioassay : cytochrome P-450 content; ethoxyresorufin O-dealkylase (EROD), pentoxyresorufin O-dealkylase (PROD), laurate hydroxylase (LH), nitrosodimethylamine N-demethylase (NDMA), glutathione S-transferase (GST) activities 8 rats in group; control group; decapitation of rats 24 h after treatment; preparation of microsomal and cytosolic fractions of rat liver; enzyme assays

Results

no changes in cytochrome P450 content; increase in PROD, NDMA activities

Citation

Canivenc-Lavier, Marie-Chantal; Vernevaut, Marie-France; Totis, Muriel; Siess, Marie-Helene; Magdalou, Jacques; Suschetet, Marc

Toxicology, 1996 , vol. 114, # 1 p. 19 - 27 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Assay Description

Effect : weight |enzyme; examination of Bioassay : hydroxilation of lauric acid to assess cytochrome P450 4A activ. by Okita; hydroxylation of p-nitrophenol as an index of P450 2E1 activ. by Okita; immunoblotting for assay P450s isoform: 1A1/2, 2B1/2, 3A1 in liver microsomes; B6C3F1 mice, 6; 4-6 week old, 20-25 g; treatment title comp. (1 percent v/v) as drinking water for 14 d; control dist. H2O; killed; liver removed; homogeniz.; subcellular fractionation by Okita

Results

treatment with title comp. signif. decrease P450 4A activ. and increased P450 2E1 activ.; treatment title comp. elevated rat P450 2B1 isoform and amount of total enzyme

Citation

Austin, Eric W.; Okita, Janice R.; Okita, Richard T.; Larson, Jeffery L.; Bull, Richard J.

Toxicology, 1995 , vol. 97, # 1-3 p. 59 - 69 Title/Abstract Full Text View citing articles Show Details

Assay Description

Effect : activation of chloroxazone 6-hydroxylation Target : Sprague-Dawley rats Bioassay : adult rats pretreated with title compd., decapitated 24 h after last treatment; hepatic microsomes prepn., incubation with 2 or 200 μM chloroxazone (20 min); HPLC anal.

Results

sex- and chloroxazone-concn.-dependent kinetic parameters (Vmax = 4.21 - 118.6 pmol/min/mg) evaluated (table)

Citation

Jayyosi; Knoble; Muc; Erick; Thomas; Kelley

Journal of Pharmacology and Experimental Therapeutics, 1995 , vol. 273, # 3 p. 1156 - 1161 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Biological material

Rattus norvegicus

Assay Description

Effect : |enzyme; examination of Bioassay : PNP hydroxylase activity was measured spectrophotometrically; CLZO hydroxylase activity was measured by HPLC 5 rats/group, 7 weeks, 160 g; rats were treated with title comp. and killed; p-nitrophenol (PNP) and chlorzoxazone (CLZO) hydroxylase activities in liver microsomes were determined by Koop and Peter, respectively

Results

title comp. slightly increased CLZO hydroxylase activity but did not affect PNP activity; hydroxylase activities for treated/control rats, nmol/(mg protein) min: 0.47/0.45 (PNP), 0.54/0.38 (CLZO)

Citation

Morel; Cossec; Lambert; Binet

Toxicology Letters, 1999 , vol. 106, # 2-3 p. 171 - 180 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Biological material

Rattus norvegicus

Assay Description

Effect : |enzyme; examination of Bioassay : 5 rats/group aged 5, 7, 9 weeks with wt. of 120, 190, 290 g, respect.; rats were treated with title comp. 24 h before sacrifice; p-nitrophenol (PNP) hydroxylase activity in liver microsomes was determined by Koop using PNP and NADPH-generating system

Results

title comp. signif. increased PNP hydroxylase activity in 7 and 9 week old rats; PNP activity for control/title comp. treated rats, nmol/(mg protein) min (age weeks): ca. 0.75/0.55 (5), 0.3/0.6

(7), 0.07/0.45 (9); presented as graph

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Citation

Morel; Cossec; Lambert; Binet

Toxicology Letters, 1999 , vol. 106, # 2-3 p. 171 - 180 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Biological material

Rattus norvegicus

Assay Description

Effect : |enzyme; examination of Bioassay : PNP hydroxylase activity was measured spectrophotometrically; CLZO hydroxylase activity was measured by HPLC 4-5 rats/group, 7 weeks, 200 g; rats were treated with title comp. and killed; p-nitrophenol (PNP) and chlorzoxazone (CLZO) hydroxylase activities in liver microsomes were determined by Koop and Peter, respectively

Results

title comp. signif. increased CLZO and PNP hydroxylase activities; hydroxylase activities for treated/control rats, nmol/(mg protein) min: 1.15/0.42 (PNP), 1.11/0.77 (CLZO)

Citation

Morel; Cossec; Lambert; Binet

Toxicology Letters, 1999 , vol. 106, # 2-3 p. 171 - 180 Title/Abstract Full Text View citing articles Show Details

Biological material

Rattus norvegicus

Assay Description

Effect : |protein binding Bioassay : ex vivo; liver removed for microsomal preparations; 50 μM <14C>L-739,010; NADPH-generating system; 37 deg C; phosphate buffer, pH 7.4; covalent binding of L-739,010 to microsomal proteins determined; liquid scintillation assay

Results

had no effect on L-739,010 binding to microsomal proteins (5.6 nmol equiv/(mg protein*h) vs. 5.7 in microsomes of untreated rats)

Citation

Zhang, Kanyin E.; Naue, Jeanne A.; Arison, Byron; Vyas, Kamlesh P.

Chemical Research in Toxicology, 1996 , vol. 9, # 2 p. 547 - 554 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; induction of Bioassay : 18 h after last treatment 20 rats killed, thymus and liver excised and treated to obtain the post-mitochondrial and microsomal fractions; zoxazolamine and p-NO2C6H4OH hydroxylation, ethylmorphine N-demethylation, pentoxyresorufin O-depentylation assayed

Results

title comp. induced metabolism of both erythromycin and p-nitrophenol in liver and thymus

Citation

Tani; Kourounakis

Pharmaceutical Sciences, 1997 , vol. 3, # 7 p. 373 - 376 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; induction of Bioassay : control: without title comp.; MALCO: microsomal alcohol oxygenase; THC: tetrahydrocannabitol 8-week-old rats were pretreated with title comp.; microsomes incubated in NADPH-generating system (pH 7.4) with 7α- and 7β-OH-Δ8-THC (12 μg) at 37 deg C for 20 min; P450 content and MALCO-activity determined with gas chromatography

Results

title comp. not induced MALCO-activity; light increase of P450 content (table)

Citation

Matsunaga, Tamihide; Shibayama, Kinya; Higuchi, Shinsuke; Tanaka, Hiroyuki; Watanabe, Kazuhito; Yamamoto, Ikuo

Biological and Pharmaceutical Bulletin, 2000 , vol. 23, # 1 p. 43 - 46 Title/Abstract Full Text View citing articles Show Details

Effect

Anaesthesic

Biological

Mus musculus

material

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Assay Description

Bioassay : single administration; observation of anesthetized animals

Results

AD50 (anaesthetic potency) 59.6 mmol/kg

Citation

Tanii, Hideji

Toxicology Letters, 1996 , vol. 85, # 1 p. 41 - 47 Title/Abstract Full Text View citing articles Show Details

Effect

Irritant

Assay Description

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Target : albino rabbit, New Zealand white strain Bioassay : young adult rabbits; SPF quality Draize test in vivo; OECD Guidelines for Testing of Chemicals (1987); test substance application in single dose to one eye; irritation degree evaluation

Results

moderate irritancy

Citation

Noever; Matsos; Cronise; Looger; Relwani; Johnson

Chemosphere, 1994 , vol. 29, # 6 p. 1373 - 1384 Title/Abstract Full Text View citing articles Show Details

Effect

Carcinogenic

Assay Description

Effect : survival Target : SENCAR mouse Bioassay : 30 rats; negative control; initiation-promotion study application to the clipped intercapsular skin; observation twice daily; clinical signs were recorded weekly for the first 13 weeks and monthly thereafter; complete histopathological evaluation after 1 year of experiment

Results

survival 28/30; no histopathological signs of carcinogenicity

Citation

Irwin, Richard D.; French, John E.; Elwell, Michael; Haseman, Joe; Braun; Voelker

Journal of Applied Toxicology, 1999 , vol. 19, # 2 p. 125 - 132 Title/Abstract Full Text View citing articles Show Details

Effect

Carcinogenic

Assay Description

Effect : tumor incidence Target : Tg.AC mouse Bioassay : homozygous 7-9-week-old mice; effect of fighting among cage mates on incidences of skin tumors in animals dosed with title comp.; historical data (HD) for comparison

Results

57 percent tumor incidence (8/14); days to first tumor: 39.4; days to maximal tumor yield: 75.3; responsiveness to title comp. was markedly affected by fighting; times to both initial and maximal tumor yield were markedly reduced relative to historical

Citation

Tennant, Raymond W.; Tice, Raymond R.; Spalding, Judson W.

Toxicology Letters, 1998 , vol. 102-103, p. 465 - 471 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Biological material

Rattus norvegicus

Assay Description

Effect : |enzyme; induction of Bioassay : control: without title comp.; p-nitrophenol UGT was assayed spectrophotometrically; incubation in mixture (mmol/l): phosphate buffer (pH 7.4), 10 sodium edetate, 5 MgCl2, 4.5 UDPGA; UGT: UDP-glucuronosyltransferase; UDPGA: UDP-glucuronic acid 6 days treatment with title comp.; liver microsomes (1-4.5 mg/ml) and 0.02-8.6 mmol/l p-nitrophenol incubated at 37 deg C with or without 0.05 percent Triton X-100 for 10 min; 15 min addition of 11 mmol/l UDPGA; influence of title comp. on UGT kinetics

Results

title comp. Km = 0.58, Vmax = 7.3; title comp. + Triton X-100 Km = 0.62, Vmax = 16; control Km = 0.41, Vmax = 4.8; control + Triton X-100 Km = 0.39, Vmax = 12; Km (mmol/l); Vmax (nmol/min/mg microsomal

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Citation

Luukkanen, Leena; Elovaara, Eivor; Lautala, Pia; Taskinen, Jyrki; Vainio, Harri

Pharmacology and Toxicology, 1997 , vol. 80, # 3 p. 152 - 158 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Biological material

Rattus norvegicus

Assay Description

Effect : |enzyme; induction of Bioassay : substrate dissolved in DMSO; control: without title comp.; UGT activity was determined by formation of glucuronide; liquid chromatography; UGT: UDP-glucuronosyltransferase; UDPGA: UDP-glucuronic acid rats received title comp. for 6 days; liver microsomes (0.005-0.4 mg/ml); reaction mixture (mmol/l): phosphate buffer pH 7.4) 50, MgCl2 10, UDPGA 4.5 and 1hydroxypyrene (10-1200 μmol/l) at 37 deg C for 10 min; UGT kinetics was determined

Results

title comp./control: Km = 0.15/0.27 mmol/l, Vmax = 34/31 nmol/min/mg microsomal protein

Citation

Luukkanen, Leena; Elovaara, Eivor; Lautala, Pia; Taskinen, Jyrki; Vainio, Harri

Pharmacology and Toxicology, 1997 , vol. 80, # 3 p. 152 - 158 Title/Abstract Full Text View citing articles Show Details

Effect

Hepatotoxic

Biological material

Rattus norvegicus

Assay Description

Bioassay : rats received title comp. for 6 days; influence of title comp. on body weight and liver weight was assessed after slaughter

Results

title comp. caused significant decrease of absolute and relative liver weight, but had no effect on body weight (table)

Citation

Luukkanen, Leena; Elovaara, Eivor; Lautala, Pia; Taskinen, Jyrki; Vainio, Harri

Pharmacology and Toxicology, 1997 , vol. 80, # 3 p. 152 - 158 Title/Abstract Full Text View citing articles Show Details

Effect

Chemoprotective

Assay Description

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Target : Sprague Dawley rats Bioassay : Sprague Dawley rats; weights, 200-300 g; exposure to test chemical in drinking water; hepatocytes were prepared; incubated with 8, 12, 16 and 20 mM hydrazine hydrate for 3 h; assayed for ATP, GSH and protein synthesis

Results

protective effect

Citation

Delaney, Jane; Timbrell, John A.

Human & Experimental Toxicology, 1994 , vol. 13, # 4 p. 292 - 292 Title/Abstract Full Text Show Details

Biological material

Rattus norvegicus

Assay Description

Effect : |metabolic Bioassay : p-nitrophenol incubation with 0.5 mg/ml liver microsomes in phosphate buffer (pH 7.5, 37 deg C); initiation by 1 mM NADH; termination by 0.06 M HClO4; nitrocatechol quantitative determination by spectrophotometry at 546 nm incubation with 0.1 mg/ml liver microsomes; cytochrome P450 2E1 (CYP2E1) activity determination by the p-nitrophenol assay

Results

two-fold elevation of CYP2E1 induction in rat liver microsomes after acetone pretreatment: 11.3 +/- 0.9 vs. 5.6 +/- 0.6 nmol p-nitrocatechol/min*nmol P450

Citation

Wilson, Andrew S.; Davis, Carl D.; Williams, Dominic P.; Buckpitt, Alan R.; Pirmohamed, Munir; Park, B. Kevin

Toxicology, 1996 , vol. 114, # 3 p. 233 - 242 Title/Abstract Full Text View citing articles Show Details

Biological material

Rattus norvegicus

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Assay Description

Effect : |AUC Bioassay : animals kept under a 12 h dark/light cycle and 20 deg C; mean 4 rats/group in saline; blood samples collected; GC method

Results

area under the curve, AUC (μg*h/ml): 1980

Citation

Scholl; Iba

Xenobiotica, 1997 , vol. 27, # 3 p. 265 - 277 Title/Abstract Full Text View citing articles Show Details

Biological material

Rattus norvegicus

Assay Description

Effect : |toxicokinetics Bioassay : animals kept under a 12 h dark/light cycle and 20 deg C; mean 4 rats/group in saline; blood samples collected; plasma elimination half-life and plasma conc., cmax (extrapolated) at time t0 determined; plasma clearance and apparent volume of distribution measurements; GC method

Results

cmax (μg/ml): 332; plasma clearance, Cl (ml/h*kg): 202, apparent volume of distribution, Vapp (l/kg): 1.2; diagram of acetone conc. in plasma

Citation

Scholl; Iba

Xenobiotica, 1997 , vol. 27, # 3 p. 265 - 277 Title/Abstract Full Text View citing articles Show Details

Biological material

Rattus norvegicus

Assay Description

Effect : |Accumulation Bioassay : animals kept under a 12 h dark/light cycle and 20 deg C; 2 rats used in drinking water; blood samples collected; GC method

Results

plasma conc. (μg/ml): 315 on day 1 and 1510 μg/ml on day 11; diagram

Citation

Scholl; Iba

Xenobiotica, 1997 , vol. 27, # 3 p. 265 - 277 Title/Abstract Full Text View citing articles Show Details

Biological material

Rattus norvegicus

Assay Description

Effect : |Accumulation Bioassay : animals kept under a 12 h dark/light cycle and 20 deg C; average values from 2 rats; 6 determinations of conc. in plasma; 8-litre glass cage vapour flow rate: 10 ml/min; blood, liver, lung and kidney samples collected; tissue levels of the title comp. determined 1 h after termination of the last inhalation; GC method

Results

conc. of the title comp. (μg/g): 35.3 (plasma), 13.2 (liver), 11.4 (lung), 21.8 (kidney)

Citation

Scholl; Iba

Xenobiotica, 1997 , vol. 27, # 3 p. 265 - 277 Title/Abstract Full Text View citing articles Show Details

Biological material

Rattus norvegicus

Assay Description

Effect : |Accumulation Bioassay : animals kept under a 12 h dark/light cycle and 20 deg C; mean 4 rats/group; 8-litre glass cage vapour flow rate: 10 ml/min; blood samples collected; plasma levels of the title comp. determined 30 min following termination to the last dose; GC method

Results

conc. of the title comp. in plasma (μg/ml): 122, 107 and 125 at day 1, 2 and 3, resp.; diagram

Citation

Scholl; Iba

Xenobiotica, 1997 , vol. 27, # 3 p. 265 - 277 Title/Abstract Full Text View citing articles Show Details

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Biological material

Rattus norvegicus

Assay Description

Effect : |AUC Bioassay : animals kept under a 12 h dark/light cycle and 20 deg C; 2 rats/group; 8-litre glass cage vapour flow rate: 10 ml/min; blood samples collected; GC method

Results

area under the curve, AUC (μg*h/ml): 960

Citation

Scholl; Iba

Xenobiotica, 1997 , vol. 27, # 3 p. 265 - 277 Title/Abstract Full Text View citing articles Show Details

Biological material

Rattus norvegicus

Assay Description

Effect : |toxicokinetics Bioassay : animals kept under a 12 h dark/light cycle and 20 deg C; 2 rats/group; 8-litre glass cage vapour flow rate: 10 ml/min; blood samples collected; plasma elimination half-life and plasma conc., cmax (extrapolated) at time t0 determined; GC method

Results

cmax (μg/ml): 146

Citation

Scholl; Iba

Xenobiotica, 1997 , vol. 27, # 3 p. 265 - 277 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; examination of Bioassay : animals kept under a 12 h dark/light cycle and 20 deg C; mean determinations from 4-8 rats; 8-litre glass cage vapour flow rate: 10 ml/min; ethoxyresorufin O-deethylase (EROD) and methoxyresorufin O-demethylase (MEROD) determined; rats killed 18 h after termination of the last inhalation; fluorometrically

Results

EROD and MEROD activity (pmol resorufin/mg microsomal protein/min): 46 (control: 57), 45 (control: 54), resp.

Citation

Scholl; Iba

Xenobiotica, 1997 , vol. 27, # 3 p. 265 - 277 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; examination of Bioassay : animals kept under a 12 h dark/light cycle and 20 deg C; mean determinations from 4-8 rats; 8-litre glass cage vapour flow rate: 10 ml/min; ethoxyresorufin O-deethylase (EROD) determined; rats killed 18 h after termination of the last inhalation; fluorometrically

Results

EROD activity (pmol resorufin/mg microsomal protein/min): 1.9 (control: 2.2)

Citation

Scholl; Iba

Xenobiotica, 1997 , vol. 27, # 3 p. 265 - 277 Title/Abstract Full Text View citing articles Show Details

Effect

Toxic

Assay Description

Target : Drosophila melanogaster strain ORR-flr3/TM3, fruitfly Bioassay : T: 22.5 deg C; usually 16 flies used (8 males and 8 females); applied to the filter paper; also under saturating conditions; exposure times leading to deep narcosis overall metabolism determined; CO2 production measurements during narcosis; correlation of body activities and CO2 production during recovery phase analysis; title compound incubated for 8-10 min

Results

length of narcosis correlated well with octanol-water coefficient; CO2 production during narcosis was not different from the reference values; dose-dependent CO2 emission diagrams

Citation

Wasserkort, Reinhold; Koller, Theodor

Journal of Applied Toxicology, 1997 , vol. 17, # 2 p. 119 - 125 Title/Abstract Full Text View citing articles Show Details

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Effect Assay Description

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Mutagenic

Target : C57BL/6 Big Blue mice Bioassay : various number of days from isolation to packaging; statistics; sources of variability of body weight; mice 9.5 weeks old; shaved mice; lacl transgenic mouse mutation assay; DNA was recovered from the skin after 7 days and analyzed in the Big Blue mutagenesis assay, modified two-tube packing method

Citation

Piegorsch; Lockhart; Margolin; Tindall; Gorelick; Short; Carr; Thompson; Shelby

Environmental and Molecular Mutagenesis, 1994 , vol. 23, # 1 p. 17 - 31 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Biological material

Rattus norvegicus

Assay Description

Effect : |enzyme; induction of Bioassay : rats weighing 180-200 g; acclimatized for 1 week (12 h light/dark cycle, water and food ad libitum); effect on protein and P450 levels, and aniline hydroxylase (AnOH) activity in liver microsomes

Results

significantly increased AnOH activity (2.55 nmoles/mg protein/min; control: 0.92); no effect on protein and P450 levels

Citation

Testai; De Curtis; Gemma; Fabrizi; Gervasi; Vittozzi

Journal of biochemical toxicology, 1996 , vol. 11, # 6 p. 305 - 312 Title/Abstract Full Text Show Details

Effect

Allergenic

Biological material

Mus musculus

Assay Description

Effect : SI Bioassay : 8-10-weeks-old mice; local lymph node assay (LLNA); cervical draining lymph node (CDLN); estimation of spontaneous level of lymph node proliferation according to 3Hthymidine incorporation title comp. was applied topically to mice on days 1-3, on day 6 LLNA was performed: 20 μCi of 3H-thymidine was i.v. inj. to mice and 5 h after mice were killed, CDLN were isolated and radioactivity was counted

Results

level of lymph node proliferation was 887 dpm/2 nodes

Citation

Woolhiser, Michael R.; Munson, Albert E.; Meade, B. Jean

Toxicology, 2000 , vol. 146, # 2-3 p. 221 - 227 Title/Abstract Full Text View citing articles Show Details

Effect

Allergenic

Assay Description

Effect : SI Target : B6C3F1 mouse Bioassay : 8-10-weeks-old mice; local lymph node assay (LLNA); cervical draining lymph node (CDLN); estimation of spontaneous level of lymph node proliferation according to 3Hthymidine incorporation title comp. was applied topically to mice on days 1-3, on day 6 LLNA was performed: 20 μCi of 3H-thymidine was i.v. inj. to mice and 5 h after mice were killed, CDLN were isolated and radioactivity was counted

Results

level of lymph node proliferation was 410 dpm/2 nodes

Citation

Woolhiser, Michael R.; Munson, Albert E.; Meade, B. Jean

Toxicology, 2000 , vol. 146, # 2-3 p. 221 - 227 Title/Abstract Full Text View citing articles Show Details

Effect

Allergenic

Assay Description

Effect : SI Target : CBA mouse Bioassay : 8-10-weeks-old mice; local lymph node assay (LLNA); cervical draining lymph node (CDLN); estimation of spontaneous level of lymph node proliferation according to 3Hthymidine incorporation title comp. was applied topically to mice on days 1-3, on day 6 LLNA was performed: 20 μCi of 3H-thymidine was i.v. inj. to mice and 5 h after mice were killed,

CDLN were isolated and radioactivity was counted

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Results

level of lymph node proliferation was 694 dpm/2 nodes

Citation

Woolhiser, Michael R.; Munson, Albert E.; Meade, B. Jean

Toxicology, 2000 , vol. 146, # 2-3 p. 221 - 227 Title/Abstract Full Text View citing articles Show Details

Effect

Allergenic

Assay Description

Effect : SI Target : DBA/2 mouse Bioassay : 8-10-weeks-old mice; local lymph node assay (LLNA); cervical draining lymph node (CDLN); estimation of spontaneous level of lymph node proliferation according to 3Hthymidine incorporation title comp. was applied topically to mice on days 1-3, on day 6 LLNA was performed: 20 μCi of 3H-thymidine was i.v. inj. to mice and 5 h after mice were killed, CDLN were isolated and radioactivity was counted

Results

level of lymph node proliferation was 345 dpm/2 nodes

Citation

Woolhiser, Michael R.; Munson, Albert E.; Meade, B. Jean

Toxicology, 2000 , vol. 146, # 2-3 p. 221 - 227 Title/Abstract Full Text View citing articles Show Details

Effect

Allergenic

Assay Description

Effect : SI Target : SJL mouse Bioassay : 8-10-weeks-old mice; local lymph node assay (LLNA); cervical draining lymph node (CDLN); estimation of spontaneous level of lymph node proliferation according to 3Hthymidine incorporation title comp. was applied topically to mice on days 1-3, on day 6 LLNA was performed: 20 μCi of 3H-thymidine was i.v. inj. to mice and 5 h after mice were killed, CDLN were isolated and radioactivity was counted

Results

level of lymph node proliferation was 2111 dpm/2 nodes

Citation

Woolhiser, Michael R.; Munson, Albert E.; Meade, B. Jean

Toxicology, 2000 , vol. 146, # 2-3 p. 221 - 227 Title/Abstract Full Text View citing articles Show Details

Assay Description

Effect : |respiratory Target : Swiss mice Bioassay : mice of body weight 24-26 g; head-only exposures in individual body plethysmograph; breathing pattern monitored daily after exposure for 7 d post-exposure

Citation

Vijayaraghavan

Archives of Toxicology, 1997 , vol. 71, # 3 p. 157 - 164 Title/Abstract Full Text View citing articles Show Details

Effect

Hepatotoxic

Biological material

Rattus norvegicus

Assay Description

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Bioassay : 12 h light/dark cycle; temp. 21 deg C bogy weight ca. 250 g; plasma alanine aminotransferase avtivity as index of hepatotoxicity

Citation

Raymond; Plaa

Journal of Toxicology and Environmental Health, 1995 , vol. 45, # 4 p. 465 - 480 Title/Abstract Full Text View citing articles Show Details

Effect

Nephrotoxic

Biological material

Rattus norvegicus

Assay

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Description

Bioassay : 12 h light/dark cycle; temp. 21 deg C bogy weight ca. 250 g; in vitro accumulation of p-aminohippuric acid in renal cortical slices

Citation

Raymond; Plaa

Journal of Toxicology and Environmental Health, 1995 , vol. 45, # 4 p. 465 - 480 Title/Abstract Full Text View citing articles Show Details

Effect

Toxic

Biological material

Rattus norvegicus

Assay Description

Effect : body weight Bioassay : 12 h light/dark cycle; temp. 21 deg C bogy weight ca. 250 g

Citation

Raymond; Plaa

Journal of Toxicology and Environmental Health, 1995 , vol. 45, # 4 p. 465 - 480 Title/Abstract Full Text View citing articles Show Details

Biological material

Rattus norvegicus

Assay Description

Effect : cytochrome P-450 content renal Bioassay : rats weight ca. 250 g; effect on renal cortical microsome total cytochrome P-450 conc.; rats killed eighteen hours after the last dose; spectrophotometric

Citation

Raymond; Plaa

Journal of Toxicology and Environmental Health, 1995 , vol. 46, # 3 p. 317 - 328 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Biological material

Rattus norvegicus

Assay Description

Effect : monooxygenase activity |enzyme; induction of Bioassay : aminopyrine and benzphetamine N-demethylase activity: colorimetric, monitoring formaldehyde formation; aniline hydroxylase activity: colorimetric, rate of formation of paminophenol rats weight ca. 250 g; effect on kidney cortical microsome aniline hydroxylase, aminopyrine N-demethylase and benzphetamine N-demethylase; rats killed eighteen hours after the last dose

Results

increased aniline hydroxylase (ca. 550 percent of control) activity; no effect on benzphetamine and aminopyrine N-demethylase activity

Citation

Raymond; Plaa

Journal of Toxicology and Environmental Health, 1995 , vol. 46, # 3 p. 317 - 328 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Biological material

Rattus norvegicus

Assay Description

Effect : monooxygenase activity |enzyme; induction of Bioassay : aminopyrine and benzphetamine N-demethylase activity: colorimetric, monitoring formaldehyde formation; aniline hydroxylase activity: colorimetric, rate of formation of paminophenol rats weight ca. 250 g; effect on liver aniline hydroxylase, aminopyrine N-demethylase and benzphetamine N-demethylase; rats killed eighteen hours after the last dose

Results

increased aniline hydroxylase activity in a dose-related fashion (ca. 170-200 percent of control); no effect on aminopyrine and benzphetamine N-demethylase activity

Citation

Raymond; Plaa

Journal of Toxicology and Environmental Health, 1995 , vol. 46, # 3 p. 317 - 328 Title/Abstract Full Text View citing articles Show Details

Effect

Hepatotoxic

Biological

Rattus norvegicus

material

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Assay Description

Effect : cytochrome P-450 content Bioassay : rats weight ca. 250 g; effect on liver microsome total cytochrome P-450 conc.; rats killed eighteen hours after the last dose; spectrophotometric

Citation

Raymond; Plaa

Journal of Toxicology and Environmental Health, 1995 , vol. 46, # 3 p. 317 - 328 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Biological material

Rattus norvegicus

Assay Description

Effect : p-nitrophenol hydroxylase activity |enzyme; induction of Bioassay : rats weight 250-300 g; in liver microsomes; specific P450 activity

Results

NPH activity: 2010 pmol/mg protein/min (control: 8)

Citation

Jenner; Timbrell

Xenobiotica, 1995 , vol. 25, # 6 p. 599 - 609 Title/Abstract Full Text View citing articles Show Details

Effect

Tumorigenic

Biological material

Mus musculus

Assay Description

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Results

no. of animals with tumour at endpoint: 0/17

Citation

Shukla; Antony; Gupta; Mehrotra

Food and Chemical Toxicology, 1994 , vol. 32, # 7 p. 651 - 654 Title/Abstract Full Text View citing articles Show Details

Effect

Neurotoxic

Assay Description

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Bioassay : body weight; topically on shaved dorsal skin; initiated with single topical injection of 7,12-dimethyl benzanthracene (DMBA) 7 d prior to promotion; promotion: 100 μl acetone 2/week for 2 wk cumulative number of tumours (CNT) and number of animals alive with tumour(s) in internal organs measured

Target : mice Bioassay : 32 mice H strain isoeffective air concentrations (ECC); interpolated; conc. evoking 30 percent depression amounting to 30 percent of maximum possible effect; critical level of effect; expressed as percent of lowest effective conc. of the conc. of saturated vapors at 37 deg C (EC10/CSV)

Results

ECC: 5000 ppm; EC10/CSV: 0.3 percent; regression analysis

Citation

Frantik; Hornychova; Horvath

Environmental Research, 1994 , vol. 66, # 2 p. 173 - 185 Title/Abstract Full Text View citing articles Show Details

Effect

Neurotoxic

Assay Description

Target : albino SPF rat Bioassay : 16 rats under 12-hr light/dark cycle isoeffective air concentrations (ECC); interpolated; conc. evoking 30 percent depression amounting to 37 percent of maximum possible effect; critical level of effect; expressed as percentage of saturated vapors at 37 deg C (ECC/CSV)

Results

ECC: 3500 ppm; ECC/CSV: 0.8 percent; regression analysis

Citation

Frantik; Hornychova; Horvath

Environmental Research, 1994 , vol. 66, # 2 p. 173 - 185 Title/Abstract Full Text View citing articles Show Details

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Biological material

Rattus norvegicus

Assay Description

Effect : influence on hepatotoxicity Bioassay : influence on hepatotoxicity of hydrazine manifested by triglyceride accumulation, depletion of ATP and reduced glutathione (GSH) 250-300 g rats; pretreated as a single dose 20 percent (v/v) 20 h before hydrazine 0-60 mg/kg i.p.; after hydrazine administration allowed only water; killed 6 h later by cervical dislocation; liver removed

Results

significant increase in liver triglyceride accumulation; no influence on GSH and ATP depletion

Citation

Jenner; Timbrell

Archives of Toxicology, 1994 , vol. 68, # 6 p. 349 - 357 Title/Abstract Full Text Show Details

Target

enzyme:Wild

Biological material

Rattus norvegicus

Assay Description

Effect : |enzyme; examination of Bioassay : influence of pretreatment on total P450 content (in nmol/mg protein), ethoxyresorufin and pentoxyresorufin O-deethylase activity (EROD and PROD), p-nitrophenol hydroxylase (NPH) activity (in pmol/mg protein per minute) 250-300 g rats; pretreated as a single 20 percent (v/v) dose 20 h before hydrazine 0-60 mg/kg i.p.; after hydrazine administration allowed only water; killed 6 h later by cervical dislocation; liver removed

Results

Total P450 content - 1.09 (control 0.93); PROD - 31 (control 8); EROD - 39 (control 35); NPH - 2010 (control 680)

Citation

Jenner; Timbrell

Archives of Toxicology, 1994 , vol. 68, # 6 p. 349 - 357 Title/Abstract Full Text Show Details

Target

enzyme:Wild

Biological material

Rattus norvegicus

Assay Description

Effect : |enzyme; induction of Bioassay : with and without starvation effect of title comp. on expression and distribution of cytochrome P450 (CYP) enzymes in kidney; monooxygenase activity measurements and immunohistochemistry of kidney section; Northern and Western blot analyses

Results

activity of CYP2E1 increased by 8-fold with 6-fold increase in CYP2E1 apoprotein; CYP2B and CYP3A apoproteins were also increased; no significant increase in CYP2E1 mRNA levels; CYP2E1 and CYP2B localized prinipally in kidney cortical tubules; table

Citation

Ronis, Martin J. J.; Huang, Jian; Longo, Vincenzo; Tindberg, Niclas; Ingelman-Sundberg, Magnus; Badger, Thomas M.

Biochemical Pharmacology, 1998 , vol. 55, # 2 p. 123 - 129 Title/Abstract Full Text View citing articles Show Details

Assay Description

Effect : |metabolic Target : microsomes of Fischer F344/N rats Bioassay : concentrations of metabolites estimated by HPLC; effect of the title compound as monooxygenase inducer on the metabolism and covalent binding to liver microsomal proteins of tamoxifen animals 6 week old; pretreated with the title compound; killed 24 h after the last dose; liver microsomal preparations were incubated (15 min) at 37 deg C with NADPH (1 mM) and tamoxifen

Results

concentrations of products of N-oxidation, N-demethylation and 4-hydroxylation of tamoxifen (diagram); pretreatment with the title compound induced covalent binding of tamoxifen (diagram)

Citation

White; De Matteis; Gibbs; Lim; Wolf; Henderson; Smith

Biochemical Pharmacology, 1995 , vol. 49, # 8 p. 1035 - 1042 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Biological material

Rattus norvegicus

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Assay Description

Effect : |enzyme; examination of Bioassay : in distilled water; 24 h prior to isolation; 5 ml/kg dose heopatocytes isolated; treated with 8-20 mM with hydrazine hydrate for 3 h; ethoxyresorufin o-deethylase, (EROD), pentoxyresorufin o-depentylase (PROD) and 4-nitrophenol hydroxylase activities measured

Results

caused a significant increase on EROD activity; no significant effect on PROD and 4-nitrophenol hydroxylase activities

Citation

Delaney; Timbrell

Xenobiotica, 1995 , vol. 25, # 12 p. 1399 - 1410 Title/Abstract Full Text View citing articles Show Details

Effect

Cytotoxic

Biological material

Rattus norvegicus

Assay Description

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55 of 69

Results

sign. reduced loss of viability in cells exposed to 20 mM of hydrazine; leakage of LDH was significantly reduced compared with non-pretreated cells

Citation

Delaney; Timbrell

Xenobiotica, 1995 , vol. 25, # 12 p. 1399 - 1410 Title/Abstract Full Text View citing articles Show Details

Assay Description

Effect : olfactory toxicity Target : Long-Evans rat Bioassay : rats under 12:12 h photoperiod at 21.0 deg C; 1 percent acetone in drinking water; sacrificed with CO2 in vivo; cytochrome P450 inhibition study; nasal microsomes prepared; P450 2E1 activities determined; Western blot analysis

Results

elevated levels of immunoreactine P450 2E1

Citation

Genter; Deamer; Cao; Levi

Journal of biochemical toxicology, 1994 , vol. 9, # 1 p. 31 - 39 Title/Abstract Full Text View citing articles Show Details

Effect

Hepatotoxic

Biological material

Rattus norvegicus

Assay Description

56 of 69

Bioassay : in distilled water; 24 h prior to isolation; 5 ml/kg dose heopatocytes isolated; treated with 8-20 mM with hydrazine hydrate for 3 h; viability assessed by tryptan blue exclusion and leakage of lactate dehydrogenase (LDH) into the incubation medium

Bioassay : 6 rats/treatment; maintained at 12-h light/dark cycle and 21 deg C; animals killed 48 h after the CCl4 treatment (18 h without CCl4); liver homogenates (Hm) and plasma membranes (PM) prepared; specific activities and enrichment factors (EF) calculated in 5 percent EL620; with/without 11.4 mmol/kg CCl4 in corn oil (ED90); enzyme activities determined in membrane fractions and homogenate (5'-nucleotidase (5N), glucose-6-phosphatase (G-6-P), leucine aminopeptidase (LAP), alkaline phosphatase (AP) monitored)

Results

5N, LAP, AP and G-6-P specific activities data and enrichment factors in homogenates and liver plasma membranes with and without CCl4; also enzyme activities in plasma membranes enriched in sinusoidal and canalicular complexes

Citation

Raymond; Plaa

Journal of Toxicology and Environmental Health, 1996 , vol. 49, # 3 p. 285 - 300 Title/Abstract Full Text View citing articles Show Details

Effect

Genotoxic

Assay Description

Results

Target : B6C3F1 mouse Bioassay : PCE: polychromatic erythrocytes; NCE: normochromatic erythrocytes; MN: micronucleus; carcinogenicity studies conducted by the National Toxicology Program (NTP); control: tap water in vivo; 10 mice per group were treated with title comp.; blood collected and stained; MN frequencies (PCE and NCE) determined using ca. 1000 cells by epifluorescence microscopy MN-NCE/1000 NCE: (dose, percent): 0.82 (control), 0.88 (1), 1.13 (2), 0.94 (5); percent PCE (dose, percent): 1.90 (control), 1.78 (1), 2.02 (2), 1.99 (5); highest negative exposure level: 5 percent; title comp.: noncarcinogenic

57 of 69

Citation

Witt, Kristine L.; Knapton, Alan; Wehr, Carol M.; Hook, Graham J.; Mirsalis, Jon; Shelby, Michael D.; MacGregor, James T.

Environmental and Molecular Mutagenesis, 2000 , vol. 36, # 3 p. 163 - 194 Title/Abstract Full Text View citing articles Show Details

Effect

Genotoxic

Assay Description

58 of 69

59 of 69

60 of 69

61 of 69

Results

MN-NCE/1000 NCE: (dose, percent): 1.52 (control), 1.41 (0.5), 1.24 (1), 1.53 (2); percent PCE (dose, percent): 2.01 (control), 1.83 (0.5), 1.94 (1), 2.10 (2); highest negative exposure level: 2 percent; title comp.: noncarcinogenic

Citation

Witt, Kristine L.; Knapton, Alan; Wehr, Carol M.; Hook, Graham J.; Mirsalis, Jon; Shelby, Michael D.; MacGregor, James T.

Environmental and Molecular Mutagenesis, 2000 , vol. 36, # 3 p. 163 - 194 Title/Abstract Full Text View citing articles Show Details

Assay Description

Effect : |metabolic Target : Fischer 344 rat Bioassay : influence on ECL metabolism; liver examination 13 male and 11 female animals; in saline; single dose; control - saline; then ethyl chloride, inhalation, 15000 ppm; sacrificed

Results

significantly increase microsomal ECL metabolism

Citation

Fedtke; Certa; Ebert; Wiegand

Archives of Toxicology, 1994 , vol. 68, # 3 p. 158 - 166 Title/Abstract Full Text View citing articles Show Details

Assay Description

Effect : |metabolic Target : B6C3F1 mice Bioassay : influence on ECL metabolism; liver examination 13 male and 11 female animals; in saline; single dose; control - saline; then treated with ethyl chloride, inhalation, 15000 ppm; sacrificed

Citation

Fedtke; Certa; Ebert; Wiegand

Archives of Toxicology, 1994 , vol. 68, # 3 p. 158 - 166 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; induction of Bioassay : EROD- ethoxyresorufin O-dealkylation; PROD - pentoxyresorufin O-dealkylation; p-NP - p-nitrophenol hydroxylation 13 male and 11 female animals; in saline; single dose; control - saline; sacrificed 24 h after last administration; liver removed

Results

EROD: 90 and 139 pmol/(min*mg) for male and female (control 50 and 62 pmol/(min*mg)); PROD: 15 and 60 pmol/(min*mg) for male and female (control 8 and 18 pmol/(min*mg)); pNP: 2.8 and 2.9 nmol/(min*mg) male and female (control 2.4 and 2.1 nmol/(min*mg)

Citation

Fedtke; Certa; Ebert; Wiegand

Archives of Toxicology, 1994 , vol. 68, # 3 p. 158 - 166 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Assay Description

Effect : |enzyme; induction of Bioassay : EROD- ethoxyresorufin O-dealkylation; PROD - pentoxyresorufin O-dealkylation; p-NP - p-nitrophenol hydroxylation 2 male and 2 female animals; in saline; single dose; control saline; sacrificed 24 h after last administration; liver removed

Results

EROD: 12 and 19 pmol/(min*mg) for male and female (control 13 and 20 pmol/(min*mg)); PROD: 50 and 12 pmol/(min*mg) for male and female (control 11 and 7 pmol/(min*mg)); p-NP: 4.4 and 5.5 nmol/(min*mg) male and female (control 1.7 and 1.3 nmol/(min*mg)

Citation

Fedtke; Certa; Ebert; Wiegand

Archives of Toxicology, 1994 , vol. 68, # 3 p. 158 - 166 Title/Abstract Full Text View citing articles Show Details

62 of 69

63 of 69

Assay Description

Effect : |metabolic Target : BALB/CJ mouse Bioassay : estimation of CYP2E1 activity in title comp.-treated microsomes according to p-nitrophenol metabolism ca. 20 g mice received title comp. with drinking water for 7 days; isolation of liver microsomes; liver microsomal test for p-nitrophenol biotransofrmation

Results

title comp. treatment led to 5-fold increase of Vmax (9.5 nmol/min/mg) and Km (88.4 μM) of p-nitrophenol metabolism

Citation

Helsby; Chipman; Gescher; Kerr

Food and Chemical Toxicology, 1998 , vol. 36, # 5 p. 375 - 382 Title/Abstract Full Text View citing articles Show Details

Effect

Toxic : Acute

Assay Description

64 of 69

65 of 69

66 of 69

Target : mammalian species Bioassay : number of species - 4; acute toxicity values obtained from published and unpublished studies from the Denver Wildlife Research Center, and from RTECS database; data restricted to oral exposure; simple linear regression model

Results

allometric scaling factor 1.128 dimensionless

Citation

Sample; Arenal

Bulletin of Environmental Contamination and Toxicology, 1999 , vol. 62, # 6 p. 653 - 663 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Biological material

Rattus norvegicus

Assay Description

Effect : |enzyme; induction of Bioassay : BI, N-benzylimidazole; CYP, cytochrome P-450 3 rats (6-week-old, 143-149 g)/group were given BI (75 mg/kg/d, p.o.) for 3 d and 5 ml/kg of title comp. on day 4, starved for 12 h and killed; liver microsomal fraction prepared; gel electrophoresis of CYP proteins; Western blotting; densitometry

Results

mean levels of CYP2E1, 2B2, 2B1, 3A2, 1A1, 1A2, and 2A1/2 (pmol/mg microsomal protein) in rats treated with BI alone/BI plus title comp., respectively: 58.2/245-256, 465/418-483, 486/766-809, 644/604-614, 285/231-257, 283/250-288, and 0/0 (immunoblots)

Citation

Mori; Koide; Fuwa; Kobayashi

Mutagenesis, 2001 , vol. 16, # 6 p. 479 - 486 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Biological material

Rattus norvegicus

Assay Description

Effect : |enzyme; induction of Bioassay : BI, N-benzylimidazole; CYP, cytochrome P-450 6-week-old (143-149 g) rats were given BI (75 mg/kg/day, p.o.) for 3 days and 5 ml/kg of title comp. on 4th day, starved for 12 h and killed; total CYP content in liver microsomes determined spectroscopically by method of Omura and Sato

Results

combined treatment with BI plus title comp. resulted in upto 1.5-fold higher CYP content compared with BI alone (P < 0.05)

Citation

Mori; Koide; Fuwa; Kobayashi

Mutagenesis, 2001 , vol. 16, # 6 p. 479 - 486 Title/Abstract Full Text View citing articles Show Details

Biological material

Mus musculus

Assay Description

Effect : |metabolic Bioassay : glucose-6-phosphate dehydrogenase; MgCl2; 0.1-10 mM TP as substrate; incub. at 37 deg C with shaking for 30 min; metabolites of TP detected by HPLC; TP: theophylline ex vivo; effect on TP metabolism assayed; 5-7-week-old mice killed after title comp. treatment; liver removed and homogenized; microsomes prepared; sodium-potassium phosphate buffer,

pH 7.4; EDTA; NADP; glucose-6-phosphate

67 of 69

68 of 69

69 of 69

Results

title comp. selectively enhanced 8-hydroxylation of TP with Km1, Km2, Vmax1 and Vmax2 values of 0.31 mM, 4.68 mM, 149 pmol/mg/min and 2500 pmol/mg/min, respectively; graphical representation

Citation

Konishi, Hiroki; Morita, Kunihiko; Yamaji, Akira

Biological and Pharmaceutical Bulletin, 1996 , vol. 19, # 4 p. 593 - 598 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Biological material

Mus musculus

Assay Description

Effect : |enzyme; induction of Bioassay : glucose-6-phosphate; glucose-6-phosphate dehydrogenase; MgCl2; 50 μM p-nitrophenol, 5 mM aminopyrine and 2.5 μM pentoxyresorufin used as substrates; incub. at 37 deg C with shaking for 5-10 min; metabolites detected by HPLC ex vivo; effect on monooxygenases activities assayed using various substrates; 5-7-week-old mice killed after title comp. treatment; liver removed and homogenized; microsomes prepared; sodium-potassium phosphate buffer, pH 7.4; EDTA; NADP

Results

title comp. stimulated hydroxylation of p-nitrophenol but had no effect on aminopyrine N-demethylase and pentoxyresorufin O-dealkylase activity; graphical representation

Citation

Konishi, Hiroki; Morita, Kunihiko; Yamaji, Akira

Biological and Pharmaceutical Bulletin, 1996 , vol. 19, # 4 p. 593 - 598 Title/Abstract Full Text View citing articles Show Details

Target

enzyme [Rana pipiens]:Wild

Assay Description

Effect : |enzyme; examination of Bioassay : tadpoles maintained in enviromental chambers at 22 deg C on a 12-h light-dark cycle; control animal not received title comp. 10 tadpoles at Gosner stage 25 in group; fed with a 3:1 mixture of ground Purina Rabbit Chow:Tetramin Fish Flakes containing title comp.; whole-body corticosterone content determined after 33 days of experiment

Results

in experiments with 100 percent title compound observed ca. 50 percent decrease of whole-body corticosterone content to ca. 200 pg/g (control ca. 400 pg/g)

Citation

Glennemeier, Karen A.; Denver, Robert J.

Environmental Toxicology, 2001 , vol. 16, # 4 p. 287 - 297 Title/Abstract Full Text View citing articles Show Details

Target

enzyme:Wild

Biological material

Rattus norvegicus

Assay Description

Effect : |enzyme; examination of Bioassay : title comp. as P4502E1 inducer; DEF deethylation determined title comp. administered to 6 - 8 weeks old animals; then animals killed by CO2 asphyxia; livers collected; microsomes prepared; incubated with diethyl formamide (DEF)

Results

kinetic parameters: Km1 = 0.07 mmol/l, Km2 = 28 mmol/l, Vmax1 = 0.18 nmol/min*mg protein, Vmax2 = 1.32 nmol/min*mg protein; deethylation followed biphasic kinetic (diagram)

Citation

Amato; Longo; Mazzaccaro; Gervasi

Chemical Research in Toxicology, 1996 , vol. 9, # 5 p. 882 - 890 Title/Abstract Full Text View citing articles Show Details

Metabolism (41) Quantitative Results pX

Parameter

Foldincrease

Value (qual)

Value (quant)

Unit

Action on Target

Target

Tissue/Organ

Cell

Cell fraction

Substrate /Carried Molecule

Dose

Reference (expand all/collapse all)

2.5

liver

Microsome

Acetaminophen

Xenobiotica, 2009 , vol...

Title/Abstract Full Text View citing articles Show Details

Laine; Auriola; Pasanen; Juvonen

Xenobiotica, 2009 , vol. 39, # 1 p. 11 - 21 Title/Abstract Full Text View citing articles Show Details

Foldincrease

2.5

liver

Microsome

Acetaminophen

Xenobiotica, 2009 , vol...

Title/Abstract Full Text View citing articles Show Details

Laine; Auriola; Pasanen; Juvonen

Xenobiotica, 2009 , vol. 39, # 1 p. 11 - 21 Title/Abstract Full Text View citing articles Show Details

Foldincrease

0.75

liver

Microsome

Lauric acid sodium

Biochemical and Biophysi...

Title/Abstract Full Text View citing articles Show Details

Amet; Berthou; Goasduff; Salaun; Le Breton; Menez

Biochemical and Biophysical Research Communications, 1994 , vol. 203, # 2 p. 1168 - 1174 Title/Abstract Full Text View citing articles Show Details

Foldincrease

2.2

liver

Microsome

Lauric acid sodium

Biochemical and Biophysi...

Title/Abstract Full Text View citing articles Show Details

Amet; Berthou; Goasduff; Salaun; Le Breton; Menez

Biochemical and Biophysical Research Communications, 1994 , vol. 203, # 2 p. 1168 - 1174 Title/Abstract Full Text View citing articles Show Details

Foldincrease

nmol/x min/mg protein

liver

Microsome

(4R)-4Vinylcyclohexene

1 %_(w/v)

Drug Metabolism and Disp...

Title/Abstract Full Text View citing articles Show Details

Fontaine, Susan M.; Mash, Eugene A.; Hoyer, Patricia B.; Sipes, I. Glenn

Drug Metabolism and Disposition, 2001 , vol. 29, # 2 p. 179 - 184 Title/Abstract Full Text View citing articles Show Details

Foldincrease

1.8

liver

Microsome

(4R)-4Vinylcyclohexene

1 %_(w/v)

Drug Metabolism and Disp...

Title/Abstract Full Text View citing articles Show Details

Fontaine, Susan M.; Mash, Eugene A.; Hoyer, Patricia B.; Sipes, I. Glenn

Drug Metabolism and Disposition, 2001 , vol. 29, # 2 p. 179 - 184 Title/Abstract Full Text View citing articles Show Details

Foldincrease

1.33

liver

Microsome

(4R)-4Vinylcyclohexene

1 %_(w/v)

Drug Metabolism and Disp...

Title/Abstract Full Text View citing articles Show Details

Fontaine, Susan M.; Mash, Eugene A.; Hoyer, Patricia B.; Sipes, I. Glenn

Drug Metabolism and Disposition, 2001 , vol. 29, # 2 p. 179 - 184 Title/Abstract Full Text View citing articles Show Details

Foldincrease

2.1

liver

Microsome

(4R)-4Vinylcyclohexene

1 %_(w/v)

Drug Metabolism and Disp...

Title/Abstract Full Text View citing articles Show Details

Fontaine, Susan M.; Mash, Eugene A.; Hoyer, Patricia B.; Sipes, I. Glenn

Drug Metabolism and Disposition, 2001 , vol. 29, # 2 p. 179 - 184 Title/Abstract Full Text View citing articles Show Details

Foldincrease

liver

Microsome

(4R)-4Vinylcyclohexene

1 %_(w/v)

Drug Metabolism and Disp...

Title/Abstract Full Text View citing articles Show Details

Fontaine, Susan M.; Mash, Eugene A.; Hoyer, Patricia B.; Sipes, I. Glenn

Drug Metabolism and Disposition, 2001 , vol. 29, # 2 p. 179 - 184 Title/Abstract Full Text View citing articles Show Details

Foldincrease

liver

Microsome

(4S)-4Vinylcyclohexene

1 %_(w/v)

Drug Metabolism and Disp...

Title/Abstract Full Text View citing articles Show Details

Fontaine, Susan M.; Mash, Eugene A.; Hoyer, Patricia B.; Sipes, I. Glenn

Drug Metabolism and Disposition, 2001 , vol. 29, # 2 p. 179 - 184 Title/Abstract Full Text View citing articles Show Details

Foldincrease

1.12

liver

Microsome

(4S)-4Vinylcyclohexene

1 %_(w/v)

Drug Metabolism and Disp...

Title/Abstract Full Text View citing articles Show Details

Fontaine, Susan M.; Mash, Eugene A.; Hoyer, Patricia B.; Sipes, I. Glenn

Drug Metabolism and Disposition, 2001 , vol. 29, # 2 p. 179 - 184 Title/Abstract Full Text View citing articles Show Details

Foldincrease

2.2

liver

Microsome

(4S)-4Vinylcyclohexene

1 %_(w/v)

Drug Metabolism and Disp...

Title/Abstract Full Text View citing articles Show Details

Fontaine, Susan M.; Mash, Eugene A.; Hoyer, Patricia B.; Sipes, I. Glenn

Drug Metabolism and Disposition, 2001 , vol. 29, # 2 p. 179 - 184 Title/Abstract Full Text View citing articles Show Details

Foldincrease

liver

Microsome

(4S)-4Vinylcyclohexene

1 %_(w/v)

Drug Metabolism and Disp...

Title/Abstract Full Text View citing articles Show Details

Fontaine, Susan M.; Mash, Eugene A.; Hoyer, Patricia B.; Sipes, I. Glenn

Drug Metabolism and Disposition, 2001 , vol. 29, # 2 p. 179 - 184 Title/Abstract Full Text View citing articles Show Details

Foldincrease

3.38

kidney

Microsome

Chlorzoxazone

Biochemical Pharmacology...

Title/Abstract Full Text View citing articles Show Details

Amet, Yolande; Zerilli, Alain; Goasduff, Thierry; Dreano, Yvonne; Berthou, Francois

Biochemical Pharmacology, 1997 , vol. 54, # 8 p. 947 - 952 Title/Abstract Full Text View citing articles Show Details

Foldincrease

4.05

kidney

Microsome

p-Nitrophenol

Biochemical Pharmacology...

Title/Abstract Full Text View citing articles Show Details

Amet, Yolande; Zerilli, Alain; Goasduff, Thierry; Dreano, Yvonne; Berthou, Francois

Biochemical Pharmacology, 1997 , vol. 54, # 8 p. 947 - 952 Title/Abstract Full Text View citing articles Show Details

Foldincrease

1.2

kidney

Microsome

Lauric acid

Biochemical Pharmacology...

Title/Abstract Full Text View citing articles Show Details

Amet, Yolande; Zerilli, Alain; Goasduff, Thierry; Dreano, Yvonne; Berthou, Francois

Biochemical Pharmacology, 1997 , vol. 54, # 8 p. 947 - 952 Title/Abstract Full Text View citing articles Show Details

Foldincrease

kidney

Microsome

Lauric acid

Biochemical Pharmacology...

Title/Abstract Full Text View citing articles Show Details

Amet, Yolande; Zerilli, Alain; Goasduff, Thierry; Dreano, Yvonne; Berthou, Francois

Biochemical Pharmacology, 1997 , vol. 54, # 8 p. 947 - 952 Title/Abstract Full Text View citing articles Show Details

Foldincrease

1.66

kidney

Microsome

Arachidonic acid

Biochemical Pharmacology...

Title/Abstract Full Text View citing articles Show Details

Amet, Yolande; Zerilli, Alain; Goasduff, Thierry; Dreano, Yvonne; Berthou, Francois

Biochemical Pharmacology, 1997 , vol. 54, # 8 p. 947 - 952 Title/Abstract Full Text View citing articles Show Details

Foldincrease

1.4

kidney

Microsome

Arachidonic acid

Biochemical Pharmacology...

Title/Abstract Full Text View citing articles Show Details

Amet, Yolande; Zerilli, Alain; Goasduff, Thierry; Dreano, Yvonne; Berthou, Francois

Biochemical Pharmacology, 1997 , vol. 54, # 8 p. 947 - 952 Title/Abstract Full Text View citing articles Show Details

2.51

3.1

Cytochrome P450 2E1 [human]:Wild

liver

Microsome

Chlorzoxazone

Chemical Research in Tox...

Title/Abstract Full Text Show Details

Peter; Bocker; Beaune; Iwasaki; Guengerich; Yang

Chemical Research in Toxicology, 1990 , vol. 3, # 6 p. 566 - 573 Title/Abstract Full Text Show Details

Parameter Foldincrease

Value (qual)

Value (quant)

Unit

1.02

Action on Target

Cell fraction

Substrate /Carried Molecule

Dose

Reference (expand all/collapse all)

liver

Microsome

Tolbutamide

Drug Metabolism and Disp...

Title/Abstract Full Text View citing articles Show Details

liver

Microsome

Tolbutamide

Drug Metabolism and Disp...

Title/Abstract Full Text View citing articles Show Details

liver

Microsome

Tolbutamide

Drug Metabolism and Disp...

Title/Abstract Full Text View citing articles Show Details

liver

Microsome

Tolbutamide

Drug Metabolism and Disp...

Title/Abstract Full Text View citing articles Show Details

Tolbutamide

Drug Metabolism and Disp...

Title/Abstract Full Text View citing articles Show Details

Tolbutamide

Drug Metabolism and Disp...

Title/Abstract Full Text View citing articles Show Details

Target

Tissue/Organ

Cytochrome P450 2C9 [human]:Wild

Cell

Palamanda, Jairam; Feng, Wei-Wei; Lin, Chin-Chung; Nomeir, Amin A.

Drug Metabolism and Disposition, 2000 , vol. 28, # 1 p. 38 - 43 Title/Abstract Full Text View citing articles Show Details

Foldincrease

1.71

Cytochrome P450 2C9 [human]:Wild

Palamanda, Jairam; Feng, Wei-Wei; Lin, Chin-Chung; Nomeir, Amin A.

Drug Metabolism and Disposition, 2000 , vol. 28, # 1 p. 38 - 43 Title/Abstract Full Text View citing articles Show Details

Foldincrease

1.75

Cytochrome P450 2C9 [human]:Wild

Palamanda, Jairam; Feng, Wei-Wei; Lin, Chin-Chung; Nomeir, Amin A.

Drug Metabolism and Disposition, 2000 , vol. 28, # 1 p. 38 - 43 Title/Abstract Full Text View citing articles Show Details

Foldincrease

1.9

Cytochrome P450 2C9 [human]:Wild

Palamanda, Jairam; Feng, Wei-Wei; Lin, Chin-Chung; Nomeir, Amin A.

Drug Metabolism and Disposition, 2000 , vol. 28, # 1 p. 38 - 43 Title/Abstract Full Text View citing articles Show Details

Foldincrease

1.5

Cytochrome P450 2C9 [human]:Wild

Palamanda, Jairam; Feng, Wei-Wei; Lin, Chin-Chung; Nomeir, Amin A.

Drug Metabolism and Disposition, 2000 , vol. 28, # 1 p. 38 - 43 Title/Abstract Full Text View citing articles Show Details

Foldincrease

2.3

Cytochrome P450 2C9 [human]:Wild

Palamanda, Jairam; Feng, Wei-Wei; Lin, Chin-Chung; Nomeir, Amin A.

Drug Metabolism and Disposition, 2000 , vol. 28, # 1 p. 38 - 43 Title/Abstract Full Text View citing articles Show Details

Foldincrease

1.4

Cytochrome P450 2C9 [human]:Wild

liver

Microsome

Tolbutamide

Drug Metabolism and Disp...

Title/Abstract Full Text View citing articles Show Details

liver

Microsome

Tolbutamide

Drug Metabolism and Disp...

Title/Abstract Full Text View citing articles Show Details

Palamanda, Jairam; Feng, Wei-Wei; Lin, Chin-Chung; Nomeir, Amin A.

Drug Metabolism and Disposition, 2000 , vol. 28, # 1 p. 38 - 43 Title/Abstract Full Text View citing articles Show Details

Foldincrease

1.4

Cytochrome P450 2C9 [human]:Wild

Palamanda, Jairam; Feng, Wei-Wei; Lin, Chin-Chung; Nomeir, Amin A.

Drug Metabolism and Disposition, 2000 , vol. 28, # 1 p. 38 - 43 Title/Abstract Full Text View citing articles Show Details

IC50

% (v/v)

Alcohol dehydrogenase:Wild

Organic and Biomolecular...

Title/Abstract Full Text View citing articles Show Details

Froehlich, Peter; Albert, Kristin; Bertau, Martin

Organic and Biomolecular Chemistry, 2011 , vol. 9, # 22 p. 7941 - 7950 Title/Abstract Full Text View citing articles Show Details

% Inhibition

Cytochrome P450 2E1 [human]:Wild

liver

Microsome

Lauric acid

0 mM

Biochemical Pharmacology...

Title/Abstract Full Text Show Details

Cytochrome P450 2E1 [human]:Wild

liver

Microsome

Lauric acid

0 mM

Biochemical Pharmacology...

Title/Abstract Full Text Show Details

Cytochrome P450 2E1 [human]:Wild

liver

Microsome

Metronidazole

5000 µM

Biochemical Pharmacology...

Title/Abstract Full Text Show Details

liver

Microsome

Dimethylnitrosamine

2 %_(v/v)

British Journal of Pharm...

Title/Abstract Full Text Show Details

liver

Microsome

Diallyl disulphide

Xenobiotica, 2003 , vol...

Title/Abstract Full Text View citing articles Show Details

Amet; Berthou; Baird; Dreano; Bail; Menez

Biochemical Pharmacology, 1995 , vol. 50, # 11 p. 1775 - 1782 Title/Abstract Full Text Show Details

IC50

Amet; Berthou; Baird; Dreano; Bail; Menez

Biochemical Pharmacology, 1995 , vol. 50, # 11 p. 1775 - 1782 Title/Abstract Full Text Show Details

% Inhibition

Loft; Otton; Lennard; Tucker; Poulsen

Biochemical Pharmacology, 1991 , vol. 41, # 8 p. 1127 - 1134 Title/Abstract Full Text Show Details

Foldincrease

2.2

Kimonen; Juvonen; Alhava; Pasanen

British Journal of Pharmacology, 1995 , vol. 114, # 4 p. 832 - 836 Title/Abstract Full Text Show Details

Foldincrease

Germain; Chevalier; Siess; Teyssier

Xenobiotica, 2003 , vol. 33, # 12 p. 1185 - 1199 Title/Abstract Full Text View citing articles Show Details

Foldincrease

liver

Microsome

Thioridazine

1 %_(v/v)

Xenobiotica, 1995 , vol...

Title/Abstract Full Text View citing articles Show Details

Blake; Rose; Mailman; Levi; Hodgson

Xenobiotica, 1995 , vol. 25, # 4 p. 377 - 393 Title/Abstract Full Text View citing articles Show Details

Foldincrease

liver

Microsome

Thioridazine

1 %_(v/v)

Xenobiotica, 1995 , vol...

Title/Abstract Full Text View citing articles Show Details

Blake; Rose; Mailman; Levi; Hodgson

Xenobiotica, 1995 , vol. 25, # 4 p. 377 - 393 Title/Abstract Full Text View citing articles Show Details

Log BB

-0.15

Acta Pharmacologica Sini...

Title/Abstract Full Text View citing articles Show Details

Ma, Xiao-Lei; Chen, Cheng; Yang, Jie

Acta Pharmacologica Sinica, 2005 , vol. 26, # 4 p. 500 - 512 Title/Abstract Full Text View citing articles Show Details

Log BB

-0.15

European Journal of Medi...

Title/Abstract Full Text View citing articles Show Details

Platts, James A.; Abraham, Michael H.; Zhao, Yuan H.; Hersey, Anne; Ijaz, Luke; Butina, Darko

European Journal of Medicinal Chemistry, 2001 , vol. 36, # 9 p. 719 - 730 Title/Abstract Full Text View citing articles Show Details

Amount

47.15

ng/min/1e6

Journal of Pharmacy and ...

cells

(v/v)

Title/Abstract Full Text View citing articles Show Details

Zhou, Xuelin; Cheung, Ching Mei; Yang, Jia-Ming; Or, Penelope M.Y.; Lee, Wayne Y.W.; Yeung, John H.K.

Journal of Pharmacy and Pharmacology, 2015 , vol. 67, # 7 p. 980 - 989 Title/Abstract Full Text View citing articles Show Details

Qualitative Information 1 of 2

2 of 2

Assay Description

Partition Coefficient of the compound was determined

Citation

S.P.Gupta

Chemical reviews, 1989 , vol. 89, # 8 p. 1765 - 1800 Title/Abstract Full Text Show Details

Assay Description

Partition Coefficient of the compound was determined

Citation

S.P.Gupta

Chemical reviews, 1989 , vol. 89, # 8 p. 1765 - 1800 Title/Abstract Full Text Show Details

Toxicity/Safety Pharmacology (89) Quantitative Results pX

Parameter

Value (qual)

Value (quant)

Unit

Action on Target

Target

Tissue/Organ

Cell

Bioassay

Dose

Effect

Reference (expand all/collapse all)

IC50

7900

mg/L

Cell/tumor cell: proliferation/viability/growth

0 mg/L

Reproductive Effect

Environmental Toxicology...

Title/Abstract Full Text View citing articles Show Details

Bogaerts, Philippe; Senaud, Jean; Bohatier, Jacques

Environmental Toxicology and Chemistry, 1998 , vol. 17, # 8 p. 1600 - 1605 Title/Abstract Full Text View citing articles Show Details

1.62

LOAEC

1380

mg/L

Cell/tumor cell: proliferation/viability/growth

Toxic

Ecotoxicology and Enviro...

Title/Abstract Full Text View citing articles Show Details

Gellert, Georg

Ecotoxicology and Environmental Safety, 2000 , vol. 45, # 1 p. 87 - 91 Title/Abstract Full Text View citing articles Show Details

Cell/tumor cell: proliferation/viability/growth

1000 ppm

Antibiotic

Journal of Coordination ...

Title/Abstract Full Text View citing articles Show Details

Sawant, Narayan V.; Biswal, Jasmine B.; Garje, Shivram S.

Journal of Coordination Chemistry, 2011 , vol. 64, # 10 p. 1758 - 1769 Title/Abstract Full Text View citing articles Show Details

MFC

Cell/tumor cell: proliferation/viability/growth

2.50000 mM

Toxic

Green Chemistry, 2010 , ...

Title/Abstract Full Text View citing articles Show Details

Petkovic, Marija; Ferguson, Jamie L.; Gunaratne, H. Q. Nimal; Ferreira, Rui; Leitao, Maria C.; Seddon, Kenneth R.; Rebelo, Luis Paulo N.; Pereira, Cristina Silva

Green Chemistry, 2010 , vol. 12, # 4 p. 643 - 649 Title/Abstract Full Text View citing articles Show Details

MIC

Cell/tumor cell: proliferation/viability/growth

2.50000 mM

Toxic

Green Chemistry, 2010 , ...

Title/Abstract Full Text View citing articles Show Details

Petkovic, Marija; Ferguson, Jamie L.; Gunaratne, H. Q. Nimal; Ferreira, Rui; Leitao, Maria C.; Seddon, Kenneth R.; Rebelo, Luis Paulo N.; Pereira, Cristina Silva

Green Chemistry, 2010 , vol. 12, # 4 p. 643 - 649 Title/Abstract Full Text View citing articles Show Details

MFC

Cell/tumor cell: proliferation/viability/growth

2.50000 mM

Toxic

Green Chemistry, 2010 , ...

Title/Abstract Full Text View citing articles Show Details

Petkovic, Marija; Ferguson, Jamie L.; Gunaratne, H. Q. Nimal; Ferreira, Rui; Leitao, Maria C.; Seddon, Kenneth R.; Rebelo, Luis Paulo N.; Pereira, Cristina Silva

Green Chemistry, 2010 , vol. 12, # 4 p. 643 - 649 Title/Abstract Full Text View citing articles Show Details

MIC

Cell/tumor cell: proliferation/viability/growth

2.50000 mM

Toxic

Green Chemistry, 2010 , ...

Title/Abstract Full Text View citing articles Show Details

Petkovic, Marija; Ferguson, Jamie L.; Gunaratne, H. Q. Nimal; Ferreira, Rui; Leitao, Maria C.; Seddon, Kenneth R.; Rebelo, Luis Paulo N.; Pereira, Cristina Silva

Green Chemistry, 2010 , vol. 12, # 4 p. 643 - 649 Title/Abstract Full Text View citing articles Show Details

MFC

Cell/tumor cell: proliferation/viability/growth

2.50000 mM

Toxic

Green Chemistry, 2010 , ...

Title/Abstract Full Text View citing articles Show Details

Petkovic, Marija; Ferguson, Jamie L.; Gunaratne, H. Q. Nimal; Ferreira, Rui; Leitao, Maria C.; Seddon, Kenneth R.; Rebelo, Luis Paulo N.; Pereira, Cristina Silva

Green Chemistry, 2010 , vol. 12, # 4 p. 643 - 649 Title/Abstract Full Text View citing articles Show Details

MIC

Cell/tumor cell: proliferation/viability/growth

2.50000 mM

Toxic

Green Chemistry, 2010 , ...

Title/Abstract Full Text View citing articles Show Details

Petkovic, Marija; Ferguson, Jamie L.; Gunaratne, H. Q. Nimal; Ferreira, Rui; Leitao, Maria C.; Seddon, Kenneth R.; Rebelo, Luis Paulo N.; Pereira, Cristina Silva

Green Chemistry, 2010 , vol. 12, # 4 p. 643 - 649 Title/Abstract Full Text View citing articles Show Details

2.7

IC50

115

ppm

Cell/tumor cell: proliferation/viability/growth

Toxic

Environmental Toxicology...

Title/Abstract Full Text View citing articles Show Details

Wan, Michael T.; Rahe, James E.

Environmental Toxicology and Chemistry, 1998 , vol. 17, # 10 p. 2041 - 2050 Title/Abstract Full Text View citing articles Show Details

EC50

288619

µM

Cell/tumor cell: proliferation/viability/growth

Toxic

Ecotoxicology and Enviro...

Title/Abstract Full Text View citing articles Show Details

Bogaerts; Bohatier; Bonnemoy

Ecotoxicology and Environmental Safety, 2001 , vol. 49, # 3 p. 293 - 301 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

Parameter

Value (qual)

Value (quant)

Unit

MIC

100

mL/L

Action on Target

Target

Tissue/Organ

Cell

Bioassay

Dose

Effect

Reference (expand all/collapse all)

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

MIC

100

mL/L

Cell/tumor cell: proliferation/viability/growth

Antifungal

Molecular Informatics, 2...

Title/Abstract Full Text View citing articles Show Details

Oros, Gyula; Naar, Zoltan; Cserhati, Tibor

Molecular Informatics, 2011 , vol. 30, # 2-3 p. 276 - 285 Title/Abstract Full Text View citing articles Show Details

500

ppm

The Journal of industria...

Full Text Show Details

M109

Journal of Medicinal Che...

Title/Abstract Full Text Show Details

Bioorganic and Medicinal...

Title/Abstract Full Text View citing articles Show Details

The Journal of industrial hygiene and toxicology, 1943 , vol. 25, p. 282 Full Text Show Details

0.15

Kier; Murray; Hall

Journal of Medicinal Chemistry, 1975 , vol. 18, # 12 p. 1272 - 1274 Title/Abstract Full Text Show Details

pEC50

0.9

Agrawal, Vijay K.; Khadikar, Padmakar V.

Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 11 p. 3517 - 3522 Title/Abstract Full Text View citing articles Show Details

3.21

LC50

0.62

Death

Chemical Biology and Dru...

Title/Abstract Full Text View citing articles Show Details

Toropova, Alla P.; Toropov, Andrey A.; Benfenati, Emilio; Gini, Giuseppina

Chemical Biology and Drug Design, 2012 , vol. 79, # 3 p. 332 - 338 Title/Abstract Full Text View citing articles Show Details

g/kg

Material Safety Data She...

Full Text Show Details

5500

mg/kg

Material Safety Data She...

Full Text Show Details

mL/kg

Material Safety Data She...

Full Text Show Details

Material Safety Data Sheet Full Text Show Details

LD50

Material Safety Data Sheet Full Text Show Details

LD50

5340

mg/kg

Material Safety Data She...

Full Text Show Details

-2.2036

Bioorganic and Medicinal...

Title/Abstract Full Text View citing articles Show Details

Material Safety Data Sheet Full Text Show Details

pGI50

Roy; Parthasarathi; Maiti; Subramanian; Chattaraj

Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 10 p. 3405 - 3412 Title/Abstract Full Text View citing articles Show Details

9400

µL/kg

Toxicology and applied p...

Title/Abstract Full Text Show Details

Toxic

Current topics in medici...

Title/Abstract Full Text Show Details

Journal of Medicinal Che...

Title/Abstract Full Text View citing articles Show Details

Roudabush; Terhaar; Fassett; Dziuba

Toxicology and applied pharmacology, 1965 , vol. 7, # 4 p. 559 - 565 Title/Abstract Full Text Show Details

LD50

g/kg

Roesch, Frank; Riss, Patrick J

Current topics in medicinal chemistry, 2010 , vol. 10, # 16 p. 1633 - 1668 Title/Abstract Full Text Show Details

2.259

µM

Wilson; Famini

Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1668 - 1674 Title/Abstract Full Text View citing articles Show Details

5.676

µM

Journal of Medicinal Che...

Title/Abstract Full Text View citing articles Show Details

Wilson; Famini

Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1668 - 1674 Title/Abstract Full Text View citing articles Show Details

pLC50

-2.1

Toxic

Pharmaceutical Chemistry...

Title/Abstract Full Text View citing articles Show Details

Grigor'ev; Raevskii

Pharmaceutical Chemistry Journal, 2011 , vol. 45, # 7 p. 406 - 411 Title/Abstract Full Text View citing articles Show Details

pLC50

-2.09

Toxic

Pharmaceutical Chemistry...

Title/Abstract Full Text View citing articles Show Details

Grigor'ev; Raevskii

Pharmaceutical Chemistry Journal, 2011 , vol. 45, # 7 p. 406 - 411 Title/Abstract Full Text View citing articles Show Details

12000

ppm

The Annals of occupation...

Title/Abstract Full Text Show Details

Toxicol. Drugs Chem., 19...

Full Text Show Details

Ross DS

The Annals of occupational hygiene, 1973 , vol. 16, # 1 p. 73 - 75 Title/Abstract Full Text Show Details

TDLo

2857

Toxicol. Drugs Chem., 1969 , vol. 64 Full Text Show Details

mg/kg

LD50

g/kg

Pharm Chem J, 1980 , vo...

Full Text Show Details

mg/kg

Journal of Toxicology an...

Title/Abstract Full Text Show Details

The Journal of pharmacy ...

Title/Abstract Full Text Show Details

Cell/tumor cell: proliferation/viability/growth

Medicinal Chemistry Rese...

Title/Abstract Full Text View citing articles Show Details

Pharm Chem J, 1980 , vol. 14, p. 162 Full Text Show Details

LD50

5800

Freeman; Hayes

Journal of Toxicology and Environmental Health, 1985 , vol. 15, # 5 p. 609 - 621 Title/Abstract Full Text Show Details

500

mg/kg

SANDERSON

The Journal of pharmacy and pharmacology, 1959 , vol. 11, # 3 p. 150 - 156 Title/Abstract Full Text Show Details

Ravindernath, Anisetti; Reddy, Malladi Srinivas; Sunil, Vodela

Medicinal Chemistry Research, 2014 , vol. 23, # 2 p. 759 - 764 Title/Abstract Full Text View citing articles Show Details

Cell/tumor cell: proliferation/viability/growth

Medicinal Chemistry Rese...

Title/Abstract Full Text View citing articles Show Details

Ravindernath, Anisetti; Reddy, Malladi Srinivas; Sunil, Vodela

Medicinal Chemistry Research, 2014 , vol. 23, # 2 p. 759 - 764 Title/Abstract Full Text View citing articles Show Details

Cell/tumor cell: proliferation/viability/growth

Medicinal Chemistry Rese...

Title/Abstract Full Text View citing articles Show Details

Ravindernath, Anisetti; Reddy, Malladi Srinivas; Sunil, Vodela

Medicinal Chemistry Research, 2014 , vol. 23, # 2 p. 759 - 764 Title/Abstract Full Text View citing articles Show Details

Cell/tumor cell: proliferation/viability/growth

Medicinal Chemistry Rese...

Title/Abstract Full Text View citing articles Show Details

Ravindernath, Anisetti; Reddy, Malladi Srinivas; Sunil, Vodela

Medicinal Chemistry Research, 2014 , vol. 23, # 2 p. 759 - 764 Title/Abstract Full Text View citing articles Show Details

Cell/tumor cell: proliferation/viability/growth

Medicinal Chemistry Rese...

Title/Abstract Full Text View citing articles Show Details

Ravindernath, Anisetti; Reddy, Malladi Srinivas; Sunil, Vodela

Medicinal Chemistry Research, 2014 , vol. 23, # 2 p. 759 - 764 Title/Abstract Full Text View citing articles Show Details

Cell/tumor cell: proliferation/viability/growth

Medicinal Chemistry Rese...

Title/Abstract Full Text View citing articles Show Details

Ravindernath, Anisetti; Reddy, Malladi Srinivas; Sunil, Vodela

Medicinal Chemistry Research, 2014 , vol. 23, # 2 p. 759 - 764 Title/Abstract Full Text View citing articles Show Details

Cell/tumor cell: proliferation/viability/growth

Medicinal Chemistry Rese...

Title/Abstract Full Text View citing articles Show Details

Ravindernath, Anisetti; Reddy, Malladi Srinivas; Sunil, Vodela

Medicinal Chemistry Research, 2014 , vol. 23, # 2 p. 759 - 764 Title/Abstract Full Text View citing articles Show Details

Cell/tumor cell: proliferation/viability/growth

Medicinal Chemistry Rese...

Title/Abstract Full Text View citing articles Show Details

Ravindernath, Anisetti; Reddy, Malladi Srinivas; Sunil, Vodela

Medicinal Chemistry Research, 2014 , vol. 23, # 2 p. 759 - 764 Title/Abstract Full Text View citing articles Show Details

Cell/tumor cell: proliferation/viability/growth

Medicinal Chemistry Rese...

Title/Abstract Full Text View citing articles Show Details

Ravindernath, Anisetti; Reddy, Malladi Srinivas; Sunil, Vodela

Medicinal Chemistry Research, 2014 , vol. 23, # 2 p. 759 - 764 Title/Abstract Full Text View citing articles Show Details

Cell/tumor cell: proliferation/viability/growth

Medicinal Chemistry Rese...

Title/Abstract Full Text View citing articles Show Details

Ravindernath, Anisetti; Reddy, Malladi Srinivas; Sunil, Vodela

Medicinal Chemistry Research, 2014 , vol. 23, # 2 p. 759 - 764 Title/Abstract Full Text View citing articles Show Details

Cell/tumor cell: proliferation/viability/growth

Medicinal Chemistry Rese...

Title/Abstract Full Text View citing articles Show Details

Ravindernath, Anisetti; Reddy, Malladi Srinivas; Sunil, Vodela

Medicinal Chemistry Research, 2014 , vol. 23, # 2 p. 759 - 764 Title/Abstract Full Text View citing articles Show Details

Cell/tumor cell: proliferation/viability/growth

Medicinal Chemistry Rese...

Title/Abstract Full Text View citing articles Show Details

Ravindernath, Anisetti; Reddy, Malladi Srinivas; Sunil, Vodela

Medicinal Chemistry Research, 2014 , vol. 23, # 2 p. 759 - 764 Title/Abstract Full Text View citing articles Show Details

% Increase

Active

0.1 % (v/v)

Cell Viability

0.1 -1 ml/l

Toxic

International Journal of...

Title/Abstract Full Text View citing articles Show Details

Xu, Xiangqun; Quan, Lili; Shen, Mengwei

International Journal of Biological Macromolecules, 2015 , vol. 77, p. 143 - 150 Title/Abstract Full Text View citing articles Show Details

% Inhibition

Not active

Aquatic Toxicology, 2017...

Title/Abstract Full Text View citing articles Show Details

Gu, Shurui; Zheng, Hao; Xu, Qingqing; Sun, Cuizhu; Shi, Mei; Wang, Zhenyu; Li, Fengmin

Aquatic Toxicology, 2017 , vol. 191, p. 122 - 130 Title/Abstract Full Text View citing articles Show Details

% Inhibition

Not active

Aquatic Toxicology, 2017...

Title/Abstract Full Text View citing articles Show Details

Gu, Shurui; Zheng, Hao; Xu, Qingqing; Sun, Cuizhu; Shi, Mei; Wang, Zhenyu; Li, Fengmin

Aquatic Toxicology, 2017 , vol. 191, p. 122 - 130 Title/Abstract Full Text View citing articles Show Details

% Decrease

Not active

Toxic : Acute

Toxins, 2017 , vol. 9, ...

Title/Abstract Full Text View citing articles Show Details

Luna-Ramirez, Karen; Skaljac, Marisa; Grotmann, Jens; Kirfel, Phillipp; Vilcinskas, Andreas

Toxins, 2017 , vol. 9, # 9 art. no. 261 Title/Abstract Full Text View citing articles Show Details

7.8

AntiMosquito

Chemical Biology and Dru...

Title/Abstract Full Text View citing articles Show Details

Dharma Rao, Bhaskara D.; Bhandary, Subhrajyoti; Chopra, Deepak; Venugopala, Katharigatta N.; Gleiser, Raquel M.; Kasumbwe, Kabange; Odhav, Bharti

Chemical Biology and Drug Design, 2017 , vol. 90, # 3 p. 397 - 405 Title/Abstract Full Text View citing articles Show Details

AntiMosquito

Chemical Biology and Dru...

Title/Abstract Full Text View citing articles Show Details

Dharma Rao, Bhaskara D.; Bhandary, Subhrajyoti; Chopra, Deepak; Venugopala, Katharigatta N.; Gleiser, Raquel M.; Kasumbwe, Kabange; Odhav, Bharti

Chemical Biology and Drug Design, 2017 , vol. 90, # 3 p. 397 - 405 Title/Abstract Full Text View citing articles Show Details

Qualitative Information 1 of 15

2 of 15

3 of 15

4 of 15

Effect

Antibiotic

Biological material

Salmonella enterica serovar Typhimurium

Assay Description

Effect : bactericidal agar cup method

Citation

Sawant, Narayan V.; Biswal, Jasmine B.; Garje, Shivram S.

Journal of Coordination Chemistry, 2011 , vol. 64, # 10 p. 1758 - 1769 Title/Abstract Full Text View citing articles Show Details

Effect

Antibiotic

Biological material

Streptococcus pneumoniae

Assay Description

Effect : bactericidal agar cup method

Citation

Sawant, Narayan V.; Biswal, Jasmine B.; Garje, Shivram S.

Journal of Coordination Chemistry, 2011 , vol. 64, # 10 p. 1758 - 1769 Title/Abstract Full Text View citing articles Show Details

Effect

Antibiotic

Biological material

Pseudomonas aeruginosa

Assay Description

Effect : bactericidal agar cup method

Citation

Sawant, Narayan V.; Biswal, Jasmine B.; Garje, Shivram S.

Journal of Coordination Chemistry, 2011 , vol. 64, # 10 p. 1758 - 1769 Title/Abstract Full Text View citing articles Show Details

Effect

Antifungal

Biological material

Aspergillus niger

Assay Description

Effect : fungicidal agar cup method

Citation

Sawant, Narayan V.; Biswal, Jasmine B.; Garje, Shivram S.

Journal of Coordination Chemistry, 2011 , vol. 64, # 10 p. 1758 - 1769 Title/Abstract Full Text View citing articles Show Details

5 of 15

6 of 15

7 of 15

8 of 15

9 of 15

10 of 15

Effect

Antifungal

Biological material

Candida albicans

Assay Description

Effect : fungicidal agar cup method

Citation

Sawant, Narayan V.; Biswal, Jasmine B.; Garje, Shivram S.

Journal of Coordination Chemistry, 2011 , vol. 64, # 10 p. 1758 - 1769 Title/Abstract Full Text View citing articles Show Details

Effect

Toxic

Assay Description

Effect : population growth kinetics Target : Tetrahymena pyriformis, protozoa Bioassay : naive (1.2E3-3E3 cells/ml) and preexposed (1.2E3-3E3 cells/ml) cells exposed with title compound, 27 deg C, vehicle, DMSO; generation and lag time determination

Results

growth rate decreased with increasing of title compound conc. in naive and preexposed cells, generation time dependent upon both preexposed conc. and transfer conc., lag population growth did not occur under any condition

Citation

Bearden, Anna P.; Gregory, Betsy W.; Schultz, T. Wayne

Ecotoxicology and Environmental Safety, 1997 , vol. 37, # 3 p. 245 - 250 Title/Abstract Full Text View citing articles Show Details

Effect

Toxic

Assay Description

Effect : growth Target : Nereis (Neanthes) arenaceodentata, marine polychaete worm Bioassay : immature adult worms; 3 percent seawater, Instant Ocean, Mentor, Ohio; TetraMarin-alflafa food slurry, 3 times/week

Results

significant and positive effect: 33.3 mg dry wt, control 16.9 mg dry wt

Citation

Emery Jr.; Dillon

Bulletin of Environmental Contamination and Toxicology, 1996 , vol. 56, # 2 p. 265 - 270 Title/Abstract Full Text Show Details

Effect

Toxic

Assay Description

Effect : growth Target : Tetrahymena pyriformis GL Bioassay : culture grown in a proteose peptone-amend. org. medium; 250-ml foam-stpper. Erlenmeyer flasks; 1.2E3 cells/ml; 27 deg C; growth kinetics from T13 to T17 and T0 to T8; electron. counts; IGC ( percent);

Results

no lag phase in growth; IGS: 21.4-85.8 percent; increas. generation time with increas. conc. of test comp.

Citation

Bearden; Gregory; Schultz

Archives of Environmental Contamination and Toxicology, 1997 , vol. 33, # 4 p. 401 - 406 Title/Abstract Full Text View citing articles Show Details

Biological material

Rattus norvegicus

Assay Description

Lethal concentration upon inhalation;Inhalation;8 hour

Citation

POZZANI; WEIL; CARPENTER

American Industrial Hygiene Association journal, 1959 , vol. 20, p. 364 - 369 Title/Abstract Full Text Show Details

Biological material

human

11 of 15

12 of 15

13 of 15

14 of 15

15 of 15

Identification Physical Data

Assay Description

Lowest published toxic concentration upon inhalation;Inhalation;6 hour

Results

TCLo not calculated

Citation

Material Safety Data Sheet Full Text Show Details

Assay Description

Toxicity of compound was determined using Tadpole narcosis test

Results

log C not calculated

Citation

Wilson; Famini

Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1668 - 1674 Title/Abstract Full Text View citing articles Show Details

Biological material

guppy

Assay Description

Konemann's industrial pollutants was determined on Poecilia reticulata (Toxicity test)

Citation

Wilson; Famini

Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1668 - 1674 Title/Abstract Full Text View citing articles Show Details

Biological material

human

Assay Description

Lowest published toxic concentration upon inhalation;Inhalation;6 min

Citation

Toxicol. Drugs Chem., 1969 , vol. 64 Full Text Show Details

Biological material

Mus musculus

Assay Description

Lethal concentration upon inhalation;Inhalation;4 hour

Citation

Curr.Toxicol., 1993, 1, 47, 1993 , vol. 1, p. 47 Full Text Show Details

Biological material

guppy

Assay Description

Aquatic toxicity of the compound in Poecilia reticulata

Citation

Katritzky; Tatham; Maran

Journal of chemical information and computer sciences, 2001 , vol. 41, # 5 p. 1162 - 1176 Title/Abstract Full Text Show Details

Spectra Other Data