Benzoyl peroxide (Dibenzoyl peroxide) [C14H10O4] by Asch

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With sodium hydroxide; dihydrogen peroxide in 1,1,2-Trichloro-1,2,2trifluoroethane

T=0 - 5°C;

Rakhimov, A. I.; Androsyuk, E. R.; Shelyazhenko, S. V.; Yagupol'skii, L. M.

Journal of Organic Chemistry USSR (English Translation), 1981 , p. 1470 - 1475 Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 8 p. 1652 - 1657 Title/Abstract Full Text Show Details

With dihydrogen peroxide; sodium carbonate

McKee

Patent: DE540588 , 1926 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 17, p. 478 Full Text Show Details

With sodium peroxide

Schwyzer,J.

Die Fabrikation pharmazeutischer und chemisch-technischer Produkte <Berlin 1931>, S. 179 Full Text Show Details

With sodium peroxide

Nencki; Zaleski

Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1899 , vol. 27, p. 493 Full Text Show Details

With barium peroxide

Brodie

Jahresbericht ueber die Fortschritte der Chemie und Verwandter Theile Anderer Wissenschaften, 1863 , p. 317 Full Text View citing articles Show Details

Brodie

Journal of the Chemical Society, 1864 , vol. 17, p. 269 Ann. d. Physik, 1864 , vol. 121, p. 377 Full Text Show Details

With sodium hydroxide; dihydrogen peroxide

Baeyer; Villiger

Chemische Berichte, 1900 , vol. 33, p. 1581 Full Text View citing articles Show Details

v. Pechmann; Vanino Chemische Berichte, 1894 , vol. 27, p. 1511 Full Text Show Details

With (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sodium peroxide; acetone

Gambarjan

Chemische Berichte, 1909 , vol. 42, p. 4010 Full Text View citing articles Show Details

With barium peroxide; water

Orndorff; White

Zeitschrift fuer Physikalische Chemie, Stoechiometrie und Verwandtschaftslehre, 1893 , vol. 12, p. 68 Full Text Show Details

Sonnenschein

Monatshefte fuer Chemie, 1886 , vol. 7, p. 522 Anm. Full Text Show Details

With sodium peroxide; water

T=0°C;

Prileshajew

Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1910 , vol. 42, p. 1409 Chem. Zentralbl., 1911 , vol. 82, # I p. 1280 Full Text View citing articles Show Details

Nencki; Zaleski

Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1899 , vol. 27, p. 493 Full Text Show Details

With sodium hydroxide; dihydrogen peroxide

D'Ans et al.

Angewandte Chemie, 1953 , vol. 65, p. 57 Full Text View citing articles Show Details

With dihydrogen peroxide; sodium dodecylsulfate; sodium hydroxide in water

T=0°C; 2.5 h; Hide Experimental Procedure

Chen, Huan-Huan; Wang, Guang-Zu; Han, Jin; Xu, Meng-Yu; Zhao, Yong-Qiang; Xu, Hua-Jian

Tetrahedron, 2014 , vol. 70, # 2 p. 212 - 217 Title/Abstract Full Text View citing articles Show Details

1:4.1 Preparation of benzoyl peroxide analogs 15

General procedure: Benzoyl peroxide analogs were prepared according to literature procedure. Sodium hydroxide (1.75 g) and 15 mL water were added into a round-bottom flask, 2.0 mL hydrogen peroxide and 0.025 g sodium dodecyl sulfate were added dropwise at 0 °C, 0.013 mol benzoyl chloride analogs were added dropwise slowly under stirring. The reaction mixture was allowed to stir an additional 2.5 h. White solid could be obtained in this reaction. The solid was filtered out and washed with methanol/water (1:1). Then, it was placed in vacuum oven to dry 24 h. 54 kg

With dihydrogen peroxide; sodium dodecylsulfate; sodium hydroxide in water

T=-5 - 5°C; 2.5 h; HeatingLarge scale; ConcentrationSolventReagent/catalyst; Hide Experimental Procedure

jiangsu wanchuan healthcare industry group co ltd; Liu, Hui; Wang, Peng; Chen, Zailing; Sun, Jue

Patent: CN105924378 A, 2016 ; Location in patent: Paragraph 0045-0048 ; Title/Abstract Full Text Show Details

The method for synthesizing peroxybenzoyl provided by the present embodiment comprises, in particular, the following steps:S21, 150 g of sodium dodecyl sulfate was dissolved in 120 kg of water at room temperature, stirred for 30 minutes, and then 18.5 kg of sodium hydroxide was added to stir to dissolve to obtain a solution which kept the solution temperature between -5 and 5 ° C, And add 24kg mass fraction of 30percent hydrogen peroxide, drop after the completion of insulation and stirring for 1 hour, to be fully reacted, the sodium peroxide solution;S22, the temperature of the sodium peroxide solution is maintained between -5 and 5 ° C, and then 50 kg of benzoyl chloride is added dropwise. After completion of the dropwise addition, the mixture is allowed to warm and stirred for 1 hour. The solution after the reaction is centrifuged, and the centrifuged solid And washed with water to obtain 54 kg of benzoyl peroxide product. 14.1 kg

With dihydrogen peroxide; ammonium bicarbonate

Jiangsu Sinobiopharma Co., Ltd.; Huang, Lequn; Chen, Quan

Patent: CN106349139 A, 2017 ;

T=30°C; 3.5 h; Large scale; Temperature; Hide Experimental Procedure

Location in patent: Paragraph 0014; 0015; 0016; 0017; 0018; 0019 ; Title/Abstract Full Text Show Details

2:Example 2

(1) synthetic process:A. 22 kg of 30percent hydrogen peroxide was added to a 50 L reactor,Open the stir,Then add 13.5 kg of ammonium bicarbonate,15 kg of benzoyl chloride was slowly added dropwise,The temperature inside the reactor is 30 degrees Celsius,Reaction time is 3.5 hours;B. The reaction solution was filtered and filtered to obtain a filter cake. The filter cake was beaten and washed in a mixed solvent of 30 kg of ethanol and 30 kg of water for 40 minutes,C. Wash with 45kg of water for 20 minutes, repeated beating washing 3 times;. D finally rinsed with 45kg of water, drained, benzoyl peroxide to give a crude white; (2) purification process:E. Add the crude benzoyl benzoate into a 200 L autoclave, add 52.5 kg of dichloromethane to the autoclave, control the temperature inside the autoclave at 30 ° C, stir to dissolve;F. 105kg of ethanol pressure filter to the high position, room temperature drop of ethanol, open the cooling, the reaction solution temperature dropped to -5 degrees Celsius, cooling crystallization 2.5 hours;G. After the crystallization is complete, the filter is filtered and the filter cake is removed and beaten with water for 20 minutes.Repeated beating washing 3 times,And finally 14.1 kg of white high purity benzoyl peroxide was obtained.The purity of benzoyl peroxide prepared in this example was 99.5percent. A

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With eosin Y disodium salt in acetonitrile

24 h; Irradiation;

Štrukil, Vjekoslav; Sajko, Igor

Chemical Communications, 2017 , vol. 53, # 65 p. 9101 - 9104 Title/Abstract Full Text View citing articles Show Details

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Rx-ID: 6718970 Find similar reactions

Norac Pharma

Patent: US2012/64135 A1, 2012 ; Title/Abstract Full Text Show Details

2:Example 2

Example 2 A benzoyl peroxide in cocoa butter composition is prepared. Cocoa butter (4.0 g) and Tween 20 (12 mL) and deionized water (235 mL) are added together and heated to 40-45° C. with overhead stirring. The mixture is stirred for 1 h. Then benzoyl peroxide (25.0 g, 74.6percent by wt) is added portionwise to the cocoa butter solution. The mixture is allowed to stir at 40-45° C. for 45 minutes then at ambient temperature overnight. After stirring, the mixture is allowed to stand for 1 h. Then the aqueous layer is decanted away. The solids are filtered and dried, resulting in a white solid (21.4 g, 70.0percent benzoyl peroxide retention). The solids are analyzed by HPLC to determine the solids contain approximately 60.6percent benzoyl peroxide (by weight). 56%

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FMC Corporation

Patent: US4235780 A1, 1980 ;

Title/Abstract Full Text Show Details

9.b:b. b. Use of benzoyl peroxide as the initiator A mixture of 1.0 g (7.93 mmol) of 3,4-dihydro-4,4-dimethyl-2H-pyran-2-one and 6.29 g (31.7 mmol) of bromotrichloromethane was heated to 100° C. Heating was maintained at 100° C. for 12 hours. During this time 600 mg (2.48 mmol) of benzoyl peroxide was added in six 100 mg portions; a 100 mg portion being added approximately every 2 hours. The reaction mixture was cooled and placed on a silica gel packed chromatography column. Elution with 20:1 hexane:ethyl acetate mixture afforded 1.45 g, 56percent yield, of 5-bromo-3,4,5,6-tetrahydro-3,3-dimethyl-6-trichloromethyl-2H-pyran-2-one. Staab,H.A. et al.

Chemische Berichte, 1965 , vol. 98, p. 1122 - 1127 Full Text View citing articles Show Details

Staab et al.

Chemische Berichte, 1965 , vol. 98, p. 1128,1132 Full Text View citing articles Show Details

Staab

Angewandte Chemie, 1962 , vol. 74, p. 407,417 Full Text Show Details

Ramirez et al.

Journal of the American Chemical Society, 1960 , vol. 82, p. 5763 Full Text View citing articles Show Details

Le Berre; Berguer

Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1965 , vol. 260, p. 1995 Full Text Show Details

Koppers Co.

Patent: GB1156573 , 1967 ; Chem.Abstr., 1969 , vol. 71, # 61023x Full Text Show Details

Pfizer; Chas and Co.; Inc.

Patent: US3438882 , 1964 ; Chem.Abstr., 1969 , vol. 71, # 12843f Full Text Show Details

Berre; Bergue

Bulletin de la Societe Chimique de France, 1966 , p. 2368,2373 Full Text Show Details

Ol'dekop et al.

Journal of Organic Chemistry USSR (English Translation), 1966 , vol. 2, p. 2133 Zhurnal Organicheskoi Khimii, 1966 , vol. 2, p. 2175 Full Text Show Details

Ivanov; Bagira

J. Appl. Chem. USSR (Engl. Transl.), 1975 , vol. 48, p. 243,243 Full Text Show Details Johnson Tetrahedron Letters, 1976 , p. 331 Full Text View citing articles Show Details Otsuka et al. Journal of the American Chemical Society, 1972 , vol. 94, p. 3761,3767 Full Text Show Details Greene; Kazan Journal of Organic Chemistry, 1963 , vol. 28, p. 2168,2169 Full Text Show Details Ol'dekop; El'nizkii J. Gen. Chem. USSR (Engl. Transl.), 1964 , vol. 34, p. 3478,3520 Full Text Show Details Voronkov et al. Soobshcheniya Akademii Nauk Gruzinskoi SSR, 1979 , vol. 93, # 1 p. 61,62,63,64 Full Text Show Details Sprecher; Nativ Tetrahedron Letters, 1968 , p. 4405 Full Text View citing articles Show Details

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Popp, Karl F.; Stiefel, Brent D.

Patent: US6433024 B1, 2002 ; Title/Abstract Full Text Show Details

3:EXAMPLE 3

EXAMPLE 3 The following benzoyl peroxide creamy wash is prepared in accordance with the procedures set forth in Example 1. The lactic acid is added along with the glycolic acid.

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Popp, Karl F.; Stiefel, Brent D.

Patent: US6433024 B1, 2002 ; Title/Abstract Full Text Show Details

4:EXAMPLE 4

EXAMPLE 4 The following benzoyl peroxide creamy wash is prepared in accordance with the procedures set forth in Example 1. The lactic acid is added at the point were the glyolic acid is added in Example 1.

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Asahi Denka Kogyo K. K.

Patent: US5929290 A1, 1999 ; Title/Abstract Full Text Show Details

6:Example 6

Example 6 A reactor equipped with a reflux condenser, a stirrer, a dropping funnel and a thermometer was charged with 100 g of xylene and the system was purged with nitrogen. Separately, a mixed solution comprising 150 g of butyl acrylate, 5 g of methacrylic acid, 15 g of the resin reforming agent of the present invention: (1-b), (5-b), (11)-(15), (17-b), (22-b) or (26), or the comparative compound (1)-(3), 2 g of benzoyl peroxide, and 0.5 g of di-tertiary butyl peroxide was prepared and it was continuously added to the reactor dropwise at a reaction temperature of 130° C. over a period of 2 hours.

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National Starch and Chemical Investment Holding Corporation

Patent: EP913445 A1, 1999 ; Title/Abstract Full Text Show Details

1:EXAMPLE 1

EXAMPLE 1 An initial charge containing 2.1 g t-octyl acrylamide, 16.76 g butyl acrylate, 5.0 g vinyl acetate, 1.0 g acrylic acid, 39.9 g ethyl acetate (solvent) and 0.04 g benzoyl peroxide (polymerization initiator) was prepared and charged to a 1-liter four-neck round bottom flask equipped with stainless steel stirrer, thermometer, condenser, water bath, slow addition funnels.

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Nitto Denko Corporation