Reaxys
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Bioactivities (23)
SigmaAldrich
Reactions (810)
Substances (1)
Structure
Targets (4)
Citations (760)
N° of preparations All Preps | All Reactions
Structure/Compound Data Chemical Name: tetra(n-butyl)ammonium hydrogensulfate Reaxys Registry Number: 3599663
CAS Registry Number: 2472-88-0 Type of Substance: acyclic Molecular Formula: C16H36N*HO4S Linear Structure Formula: (C4H9)4N(1+)*HSO4(1-)=[(C4H9)4N]HSO4
8 prep out of 810 reactions.
Available Data
Target
N° of ref.
Druglikeness
Bioactivity
Identification Physical Data (147) Spectra (4) Other Data (12)
Show Targets
760
Molecular Weight: 339.54 InChI Key: SHFJWMWCIHQNCP-UHFFFAOYSA-M
1
Synthesize | Hide Details Find similar Chemical Names and Synonyms tetra(n-butyl)ammonium hydrogensulfate, tetrabutylammonium hydrogensulfate, tetra-n-butyl ammonioum hydrogen sulfate, tetrabutylammonium hydrogen sulfate salt, tetra n-butyl ammonium hydrogen sulfate, tetra(n-butyl)ammonium hydrogen sulfate, tetra-n-butyl ammonium hydrogen sulfate Druglikeness Bioactivity In vitro: Efficacy (21) Quantitative Results pX
Parameter
Value (qual)
Value (quant)
Unit
Action on Target
Target
Tissue/Organ
Cell
Bioassay
Dose
Effect
Reference (expand all/collapse all) Journal of Antibiotics, ...
Title/Abstract Full Text View citing articles Show Details
Watanabe, Hiroshi; Azuma, Masayuki; Igarashi, Koicbi; Ooshima, Hiroshi
Journal of Antibiotics, 2006 , vol. 59, # 5 p. 281 - 287 Title/Abstract Full Text View citing articles Show Details
Journal of Antibiotics, ...
Title/Abstract Full Text View citing articles Show Details
Watanabe, Hiroshi; Azuma, Masayuki; Igarashi, Koicbi; Ooshima, Hiroshi
Journal of Antibiotics, 2006 , vol. 59, # 5 p. 281 - 287 Title/Abstract Full Text View citing articles Show Details
Journal of Antibiotics, ...
Title/Abstract Full Text View citing articles Show Details
Watanabe, Hiroshi; Azuma, Masayuki; Igarashi, Koicbi; Ooshima, Hiroshi
Journal of Antibiotics, 2006 , vol. 59, # 5 p. 281 - 287 Title/Abstract Full Text View citing articles Show Details
Journal of Antibiotics, ...
Title/Abstract Full Text View citing articles Show Details
Watanabe, Hiroshi; Azuma, Masayuki; Igarashi, Koicbi; Ooshima, Hiroshi
Journal of Antibiotics, 2006 , vol. 59, # 5 p. 281 - 287 Title/Abstract Full Text View citing articles Show Details
Journal of Antibiotics, ...
Title/Abstract Full Text View citing articles Show Details
Watanabe, Hiroshi; Azuma, Masayuki; Igarashi, Koicbi; Ooshima, Hiroshi
Journal of Antibiotics, 2006 , vol. 59, # 5 p. 281 - 287 Title/Abstract Full Text View citing articles Show Details
Journal of Antibiotics, ...
Title/Abstract Full Text View citing articles Show Details
Watanabe, Hiroshi; Azuma, Masayuki; Igarashi, Koicbi; Ooshima, Hiroshi
Journal of Antibiotics, 2006 , vol. 59, # 5 p. 281 - 287 Title/Abstract Full Text View citing articles Show Details
Journal of Antibiotics, ...
Title/Abstract Full Text View citing articles Show Details
Watanabe, Hiroshi; Azuma, Masayuki; Igarashi, Koicbi; Ooshima, Hiroshi
Journal of Antibiotics, 2006 , vol. 59, # 5 p. 281 - 287 Title/Abstract Full Text View citing articles Show Details
Journal of Antibiotics, ...
Title/Abstract Full Text View citing articles Show Details
Watanabe, Hiroshi; Azuma, Masayuki; Igarashi, Koicbi; Ooshima, Hiroshi
Journal of Antibiotics, 2006 , vol. 59, # 5 p. 281 - 287 Title/Abstract Full Text View citing articles Show Details
Journal of Antibiotics, ...
Title/Abstract Full Text View citing articles Show Details
Watanabe, Hiroshi; Azuma, Masayuki; Igarashi, Koicbi; Ooshima, Hiroshi
Journal of Antibiotics, 2006 , vol. 59, # 5 p. 281 - 287 Title/Abstract Full Text View citing articles Show Details
Journal of Antibiotics, ...
Title/Abstract Full Text View citing articles Show Details
Watanabe, Hiroshi; Azuma, Masayuki; Igarashi, Koicbi; Ooshima, Hiroshi
Journal of Antibiotics, 2006 , vol. 59, # 5 p. 281 - 287
Title/Abstract Full Text View citing articles Show Details
Journal of Antibiotics, ...
Title/Abstract Full Text View citing articles Show Details
Watanabe, Hiroshi; Azuma, Masayuki; Igarashi, Koicbi; Ooshima, Hiroshi
Journal of Antibiotics, 2006 , vol. 59, # 5 p. 281 - 287 Title/Abstract Full Text View citing articles Show Details
1
% Inhibition
12
%
Arylacetamide deacetylase [human]:Wild
Sf21 cell line
Enzymology inhibition
100 µM
Drug Metabolism and Disp...
Title/Abstract Full Text View citing articles Show Details
Shimizu, Mai; Fukami, Tatsuki; Nakajima, Miki; Yokoi, Tsuyoshi
Drug Metabolism and Disposition, 2014 , vol. 42, # 7 p. 1103 - 1109 Title/Abstract Full Text View citing articles Show Details
1
% Inhibition
0
%
Inhibitor
UDPglucuronosyltransferase 1-8:Wild
20 μM
Drug Metabolism and Disp...
Title/Abstract Full Text View citing articles Show Details
Oda, Shingo; Fujiwara, Ryoichi; Kutsuno, Yuki; Fukami, Tatsuki; Itoh, Tomoo; Yokoi, Tsuyoshi; Nakajima, Miki
Drug Metabolism and Disposition, 2015 , vol. 43, # 6 p. 812 - 818 Title/Abstract Full Text View citing articles Show Details
1
% Inhibition
0
%
Inhibitor
UDPglucuronosyltransferase 1-8:Wild
20 μM
Drug Metabolism and Disp...
Title/Abstract Full Text View citing articles Show Details
Oda, Shingo; Fujiwara, Ryoichi; Kutsuno, Yuki; Fukami, Tatsuki; Itoh, Tomoo; Yokoi, Tsuyoshi; Nakajima, Miki
Drug Metabolism and Disposition, 2015 , vol. 43, # 6 p. 812 - 818 Title/Abstract Full Text View citing articles Show Details
1
% Inhibition
0
%
Inhibitor
UDPglucuronosyltransferase 1-8:Wild
20 μM
Drug Metabolism and Disp...
Title/Abstract Full Text View citing articles Show Details
Oda, Shingo; Fujiwara, Ryoichi; Kutsuno, Yuki; Fukami, Tatsuki; Itoh, Tomoo; Yokoi, Tsuyoshi; Nakajima, Miki
Drug Metabolism and Disposition, 2015 , vol. 43, # 6 p. 812 - 818 Title/Abstract Full Text View citing articles Show Details
Qualitative Information 1 of 6
2 of 6
3 of 6
Assay Description
Effect : |transport Target : human placental syncytial microvillus membrane vesicles Bioassay : in vitro; effect on choline uptake assayed; 250 μM <3H>choline; 100 mM mannitol; 100 mM KCl; 20 μM valinomycin; Hepes-Tris, pH 7.4; 37 deg C; rapid filtration technique
Results
title comp. inhibited <3H>choline uptake; graphical representation
Citation
Van Der AA; Wouterse; Peereboom-Stegeman; Russel
Biochemical Pharmacology, 1995 , vol. 50, # 11 p. 1873 - 1878 Title/Abstract Full Text Show Details
Assay Description
Effect : |agonist Target : New Zealand White rabbit carotid artery Bioassay : force displacement transducer; Grass polygraph; rings contracted with phenylephrine (1μM); concentration-response curve; effect on L-NAME (30μM)/indomethacin (10μM) insensitive relaxation to acethylcholine (ACh) rabbits (1-2 kg) killed by exsanguination; common carotid artery quickly excised, adherent fat and connective tissue removed, cut into 5 mm rings; pretreatment with title compound (K+ channel blocker)
Results
title compound completely inhibited L-NAME/indomethacin insensitive response to ACh
Citation
Dong, Hui; Waldron, Gareth J.; Galipeau, Denise; Cole, William C.; Triggle, Christopher R.
British Journal of Pharmacology, 1997 , vol. 120, # 4 p. 695 - 701 Title/Abstract Full Text View citing articles Show Details
Biological material
Staphylococcus epidermidis ATCC 12228
4 of 6
5 of 6
6 of 6
Assay Description
Minimum inhibitory concentration of the compound against Staphylococcus epidermidis ATCC12228 upon incubation for 24 h at 37 degree C
Results
MIC not calculated
Citation
Ingalsbe, Michelle L.; Denis, Jeffrey D.St.; McGahan, Megan E.; Steiner, Walter W.; Priefer, Ronny
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 17 p. 4984 - 4987 Title/Abstract Full Text View citing articles Show Details
Biological material
Staphylococcus epidermidis ATCC 12228
Assay Description
Antimicrobial efficacy expressed as ratio of reciprocal of y-intercept as maximum zone of inhibition to that of negative reciprocal of x-intercept as concentration to one-half maximum zone of inhibition against Staphylococcus epidermidis ATCC12228 upon incubation for 24 h at 37 degree C with compound dissolved in DMSO by halo test
Results
Antimicrobial efficacy not calculated
Citation
Ingalsbe, Michelle L.; Denis, Jeffrey D.St.; McGahan, Megan E.; Steiner, Walter W.; Priefer, Ronny
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 17 p. 4984 - 4987 Title/Abstract Full Text View citing articles Show Details
Biological material
Escherichia coli K 12 C600
Assay Description
Minimum inhibitory concentration of the compound against Escherichia coli K-12 C600 upon incubation for 24 h at 37 degree C
Results
MIC not calculated
Citation
Ingalsbe, Michelle L.; Denis, Jeffrey D.St.; McGahan, Megan E.; Steiner, Walter W.; Priefer, Ronny
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 17 p. 4984 - 4987 Title/Abstract Full Text View citing articles Show Details
Biological material
Escherichia coli K 12 C600
Assay Description
Antimicrobial efficacy expressed as ratio of reciprocal of y-intercept as maximum zone of inhibition to that of negative reciprocal of x-intercept as concentration to one-half maximum zone of inhibition against Escherichia coli K-12 C600 upon incubation for 24 h at 37 degree C with compound dissolved in DMSO by halo test
Results
Antimicrobial efficacy not calculated
Citation
Ingalsbe, Michelle L.; Denis, Jeffrey D.St.; McGahan, Megan E.; Steiner, Walter W.; Priefer, Ronny
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 17 p. 4984 - 4987 Title/Abstract Full Text View citing articles Show Details
Metabolism (2) Quantitative Results pX
Parameter
1
% Inhibition
Value (qual)
Value (quant)
Unit
Action on Target
1
%
Cell fraction
Target
Tissue/Organ
Cell
Carboxylesterase 1 [human]:Wild
Sf21 cell line
Sf21 cell line
Substrate /Carried Molecule
Dose
Reference (expand all/collapse all)
4Nitrophenyl acetate
100 µM
Drug Metabolism and Disp...
Title/Abstract Full Text View citing articles Show Details
4Nitrophenyl acetate
100 µM
Shimizu, Mai; Fukami, Tatsuki; Nakajima, Miki; Yokoi, Tsuyoshi
Drug Metabolism and Disposition, 2014 , vol. 42, # 7 p. 1103 - 1109 Title/Abstract Full Text View citing articles Show Details
1
% Inhibition
19
%
Carboxylesterase 2 [human]:Wild
Drug Metabolism and Disp...
Title/Abstract Full Text View citing articles Show Details
Shimizu, Mai; Fukami, Tatsuki; Nakajima, Miki; Yokoi, Tsuyoshi
Drug Metabolism and Disposition, 2014 , vol. 42, # 7 p. 1103 - 1109 Title/Abstract Full Text View citing articles Show Details
Identification Physical Data Spectra Other Data