Reaxys
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Substances (3)
Structure
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Citations (9)
N° of preparations All Preps | All Reactions
Structure/Compound Data Chemical Name: 1-[1-(3-methoxy-phenyl)-cyclohexyl]-piperidine
5 prep out of 9 reactions.
Reaxys Registry Number: 1252112
CAS Registry Number: 72242-03-6 Type of Substance: heterocyclic Molecular Formula: C18H27NO Linear Structure Formula: C18H27NO Molecular Weight: 273.418
InChI Key: BQQSZHHKGPOXLN-UHFFFAOYSA-N
1
Available Data
Target
N° of ref.
Druglikeness
Bioactivity
Identification Spectra (1)
Show Targets
7
Synthesize | Hide Details Find similar Chemical Names and Synonyms 1-[1-(3-methoxy-phenyl)-cyclohexyl]-piperidine Druglikeness Bioactivity In vivo: Animal Model (1) Quantitative Results pX
Parameter ED50
Value (qual)
Value (quant)
Unit
4.8
mg/kg
Action on Target
Animal Model
Biological Species
Route of administration
Swiss Webster mouse
subcutaneous administration
Dose
Dosing regimen Single
Effect
Reference (expand all/collapse all) European Journal of Medi...
Title/Abstract Full Text View citing articles Show Details
Geneste; Kamenka; Ung; et al.
European Journal of Medicinal Chemistry, 1979 , vol. 14, # 4 p. 301 - 308 Title/Abstract Full Text View citing articles Show Details
Identification Spectra Chemical Name: [11C]-N-[1-(3-methoxyphenyl)cyclohexyl]piperidine Reaxys Registry Number: 8173165
Type of Substance: heterocyclic Molecular Formula: C18H27NO*ClH Linear Structure Formula: C17(11)CH27NO*ClH
1 prep out of 1 reactions.
Druglikeness
Bioactivity
Identification
Show Targets
1
Molecular Weight: 308.868
InChI Key: MFBXZMQWSUHTBV-ULWFUOSBSA-N
2
Synthesize | Hide Details Find similar Chemical Names and Synonyms [11C]-N-[1-(3-methoxyphenyl)cyclohexyl]piperidine Druglikeness Bioactivity In vivo: Animal Model (2) Qualitative Information 1 of 2
2 of 2
Biological material
Mus musculus
Assay Description
Effect : |transport Bioassay : in vivo; treatment with title comp.; mice were killed and brain was removed; distribution of 11C in blood were determined at 1, 5, 15, 30 min after dosing
Results
blood, percent dose/g: 1.59 (1 min), 1.47 (5 min), 1.06, (15 min), 0.70 (30 min)
Citation
Haradahira, Terushi; Sasaki, Sigeki; Maeda, Minoru; Kobayashi, Kaoru; Inoue, Osamu; Tomita, Urara; Nishikawa, Toru; Suzuki, Kazutoshi
Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 9 p. 843 - 858 Title/Abstract Full Text View citing articles Show Details
Biological material
Mus musculus
Assay Description
Effect : |transport Bioassay : in vivo; treatment with title comp.; mice were killed and brain was removed; distribution of 11C in 4 brain regions were determined at 1, 5, 15, 30 min after dosing
Results
cerebral cortex, percent dose/g, at 1/5/15/30 min: 1.45/1.68/1.28/0.85; hippocampus, percent dose/g, at 1/5/15/30 min: 1.43/1.47/1.22/0.80; striatum, percent dose/g, at 1/5/15/30 min: 1.56/1.72/1.26/0.80; cerebellum, percent dose/g, at 1/5/15/30
Citation
Haradahira, Terushi; Sasaki, Sigeki; Maeda, Minoru; Kobayashi, Kaoru; Inoue, Osamu; Tomita, Urara; Nishikawa, Toru; Suzuki, Kazutoshi
Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 9 p. 843 - 858 Title/Abstract Full Text View citing articles Show Details
Identification Chemical Name:
1 prep
Druglikeness
Show Targets
2
N-[1-(3-methoxyphenyl)cyclohexyl]piperidine Reaxys Registry Number: 4606231
CAS Registry Number: 91164-58-8 Type of Substance: heterocyclic Molecular Formula: C18H27NO*ClH Linear Structure Formula: C18H27NO*ClH Molecular Weight: 309.879
InChI Key: MFBXZMQWSUHTBV-UHFFFAOYSA-N
3
Synthesize | Show Details Find similar
out of 2 reactions.
Identification Physical Data (3) Spectra (4)