Query Query
1. Query O
N
Results
Date
7 reactions in Reaxys
2018-03-25 13h:03m:51s (EST)
Search as: As drawn
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
1/3
2018-03-25 13:18:29
N
N
N
HO
O
N
Rx-ID: 1469174 View in Reaxys 1/7 Yield
Conditions & References in diethyl ether, ethanol, Time= 0.5h, Ambient temperature Masumoto; Takeuchi; Ohta; Hirobe; Chemical and Pharmaceutical Bulletin; vol. 37; nb. 7; (1989); p. 1788 - 1794 View in Reaxys
O
N
Rx-ID: 6429863 View in Reaxys 2/7 Yield
Conditions & References Cyclohexanoncyanhydrin, Piperidin, m-Methoxyphenylmagnesiumbromid Geneste et al.; European Journal of Medicinal Chemistry; vol. 14; (1979); p. 301,302 View in Reaxys
H N N
O
Rx-ID: 30499110 View in Reaxys 3/7 Yield
Conditions & References Reaction Steps: 2 1: toluene / 12 h / 130 °C 2: tetrahydrofuran / -78 - 20 °C in tetrahydrofuran, toluene Zarantonello, Paola; Bettini, Ezio; Paio, Alfredo; Simoncelli, Chiara; Terreni, Silvia; Cardullo, Francesco; Bioorganic and Medicinal Chemistry Letters; vol. 21; nb. 7; (2011); p. 2059 - 2063 View in Reaxys
Br N
Mg
O
N
N
O
N
N
Rx-ID: 30499145 View in Reaxys 4/7 Yield
Conditions & References in tetrahydrofuran, T= -78 - 20 °C Zarantonello, Paola; Bettini, Ezio; Paio, Alfredo; Simoncelli, Chiara; Terreni, Silvia; Cardullo, Francesco; Bioorganic and Medicinal Chemistry Letters; vol. 21; nb. 7; (2011); p. 2059 - 2063 View in Reaxys
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
2/3
2018-03-25 13:18:29
O
N
O
Rx-ID: 30499203 View in Reaxys 5/7 Yield
Conditions & References Reaction Steps: 2 1: toluene / 12 h / 130 °C 2: tetrahydrofuran / -78 - 20 °C in tetrahydrofuran, toluene Zarantonello, Paola; Bettini, Ezio; Paio, Alfredo; Simoncelli, Chiara; Terreni, Silvia; Cardullo, Francesco; Bioorganic and Medicinal Chemistry Letters; vol. 21; nb. 7; (2011); p. 2059 - 2063 View in Reaxys
H 311C
I
HO
H 11 3 C
N
O
Cl
N
H
Rx-ID: 5050985 View in Reaxys 6/7 Yield 92 %
Conditions & References With sodium hydride in N,N-dimethyl-formamide, Time= 0.0833333h, T= -50 - 50 °C , Methylation Haradahira, Terushi; Sasaki, Sigeki; Maeda, Minoru; Kobayashi, Kaoru; Inoue, Osamu; Tomita, Urara; Nishikawa, Toru; Suzuki, Kazutoshi; Journal of Labelled Compounds and Radiopharmaceuticals; vol. 41; nb. 9; (1998); p. 843 - 858 View in Reaxys
Br
Br O
H 2N
N
O
Cl
H
Rx-ID: 5049048 View in Reaxys 7/7 Yield 72 %
Conditions & References With potassium carbonate in N,N-dimethyl-formamide, Time= 48h, T= 60 °C , Addition, cyclization Haradahira, Terushi; Sasaki, Sigeki; Maeda, Minoru; Kobayashi, Kaoru; Inoue, Osamu; Tomita, Urara; Nishikawa, Toru; Suzuki, Kazutoshi; Journal of Labelled Compounds and Radiopharmaceuticals; vol. 41; nb. 9; (1998); p. 843 - 858 View in Reaxys
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
3/3
2018-03-25 13:18:29