Reaxys
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Bioactivities (13)
SigmaAldrich
Reactions (6)
Substances (2)
Structure
Targets (2)
Citations (11)
N° of preparations All Preps | All Reactions
Structure/Compound Data Chemical Name: 1-[1-(4-methoxy-phenyl)-cyclohexyl]-piperidine
5 prep out of 6 reactions.
Reaxys Registry Number: 1252117
CAS Registry Number: 2201-35-6 Type of Substance: heterocyclic Molecular Formula: C18H27NO Linear Structure Formula: C18H27NO Molecular Weight: 273.418
InChI Key: MUZGGFNYVLGUFS-UHFFFAOYSA-N
1
Available Data
Target
N° of ref.
Druglikeness
Bioactivity
Identification Physical Data (4) Spectra (2)
Show Targets
9
Synthesize | Hide Details Find similar Chemical Names and Synonyms 1-[1-(4-methoxy-phenyl)-cyclohexyl]-piperidine, 1-<1-(4-Methoxy-phenyl)-cyclohexyl>-piperidin Druglikeness Bioactivity In vitro: Efficacy (4) Quantitative Results pX
Parameter
4.8
pIC50
Value (qual)
Value (quant) 4.8
Unit
Action on Target Antagonist
Target Glutamate receptor ionotropic, NMDA 2A
Tissue/Organ
Cell
Bioassay
U-2 OS
Flux uptake
Dose
Effect
Reference (expand all/collapse all) Bioorganic and Medicinal...
Title/Abstract Full Text View citing articles Show Details
[human]:Wild + Glutamate receptor ionotropic, NMDA 1 [human]:Wild Zarantonello, Paola; Bettini, Ezio; Paio, Alfredo; Simoncelli, Chiara; Terreni, Silvia; Cardullo, Francesco
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 7 p. 2059 - 2063 Title/Abstract Full Text View citing articles Show Details
5.4
pIC50
5.4
Antagonist
Glutamate receptor ionotropic, NMDA 2B [human]:Wild + Glutamate receptor ionotropic, NMDA 1 [human]:Wild
U-2 OS
Flux uptake
Bioorganic and Medicinal...
Title/Abstract Full Text View citing articles Show Details
Zarantonello, Paola; Bettini, Ezio; Paio, Alfredo; Simoncelli, Chiara; Terreni, Silvia; Cardullo, Francesco
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 7 p. 2059 - 2063 Title/Abstract Full Text View citing articles Show Details
Emax(%)
94 - 100
%
Antagonist
Glutamate receptor ionotropic, NMDA 2A [human]:Wild + Glutamate receptor ionotropic, NMDA 1 [human]:Wild
U-2 OS
Flux uptake
Bioorganic and Medicinal...
Title/Abstract Full Text View citing articles Show Details
Zarantonello, Paola; Bettini, Ezio; Paio, Alfredo; Simoncelli, Chiara; Terreni, Silvia; Cardullo, Francesco
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 7 p. 2059 - 2063 Title/Abstract Full Text View citing articles Show Details
Emax(%)
94 - 100
%
Antagonist
Glutamate receptor ionotropic, NMDA 2B [human]:Wild + Glutamate receptor ionotropic, NMDA 1 [human]:Wild
U-2 OS
Flux uptake
Bioorganic and Medicinal...
Title/Abstract Full Text View citing articles Show Details
Zarantonello, Paola; Bettini, Ezio; Paio, Alfredo; Simoncelli, Chiara; Terreni, Silvia; Cardullo, Francesco
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 7 p. 2059 - 2063 Title/Abstract Full Text View citing articles Show Details
In vivo: Animal Model (1) Quantitative Results pX
Parameter ED50
Value (qual)
Value (quant)
Unit
20
mg/kg
Action on Target
Animal Model
Biological Species
Route of administration
Swiss Webster mouse
subcutaneous administration
Dose
Dosing regimen
Effect
Single
Reference (expand all/collapse all) European Journal of Medi...
Title/Abstract Full Text View citing articles Show Details
Geneste; Kamenka; Ung; et al.
European Journal of Medicinal Chemistry, 1979 , vol. 14, # 4 p. 301 - 308 Title/Abstract Full Text View citing articles Show Details
Identification Physical Data Spectra Reaxys Registry Number: 4606236
CAS Registry Number: 2185-93-5 Type of Substance: heterocyclic
no reactions.
Druglikeness
Bioactivity
Identification
Show Targets
3
Molecular Formula: C18H27NO*ClH Linear Structure Formula: C18H27NO*ClH Molecular Weight: 309.879
InChI Key: FYAFJNVLHWQLHK-UHFFFAOYSA-N 2
Physical Data (1) Spectra (1)
Synthesize | Hide Details Find similar
Druglikeness Bioactivity In vitro: Efficacy (6) Quantitative Results pX
Parameter
Value (qual)
Value (quant)
Unit
Action on Target
Target
Tissue/Organ
Cell
Bioassay
Dose
Effect
Reference (expand all/collapse all)
Number
2
Journal of medicinal che...
Title/Abstract Full Text View citing articles Show Details
Kalir; Edery; Pelah; Balderman; Porath
Journal of medicinal chemistry, 1969 , vol. 12, # 3 p. 473 - 477 Title/Abstract Full Text View citing articles Show Details
%
=
0
%
Journal of medicinal che...
Title/Abstract Full Text View citing articles Show Details
Kalir; Edery; Pelah; Balderman; Porath
Journal of medicinal chemistry, 1969 , vol. 12, # 3 p. 473 - 477 Title/Abstract Full Text View citing articles Show Details
Number
2
Journal of medicinal che...
Title/Abstract Full Text View citing articles Show Details
Kalir; Edery; Pelah; Balderman; Porath
Journal of medicinal chemistry, 1969 , vol. 12, # 3 p. 473 - 477 Title/Abstract Full Text View citing articles Show Details
%
=
0
%
Journal of medicinal che...
Title/Abstract Full Text View citing articles Show Details
Kalir; Edery; Pelah; Balderman; Porath
Journal of medicinal chemistry, 1969 , vol. 12, # 3 p. 473 - 477 Title/Abstract Full Text View citing articles Show Details
Number
0
Journal of medicinal che...
Title/Abstract Full Text View citing articles Show Details
Kalir; Edery; Pelah; Balderman; Porath
Journal of medicinal chemistry, 1969 , vol. 12, # 3 p. 473 - 477 Title/Abstract Full Text View citing articles Show Details
%
=
0
%
Journal of medicinal che...
Title/Abstract Full Text View citing articles Show Details
Kalir; Edery; Pelah; Balderman; Porath
Journal of medicinal chemistry, 1969 , vol. 12, # 3 p. 473 - 477 Title/Abstract Full Text View citing articles Show Details
In vivo: Animal Model (2) Quantitative Results pX
Parameter
Value (qual)
Activity
ND
Value (quant)
Unit
Action on Target
Animal Model
Biological Species
Route of administration
pigeon
intramuscular administration
Dose
Dosing regimen
Effect
MADDOX; GODEFROI; PARCELL
Journal of medicinal chemistry, 1965 , vol. 8, p. 230 - 235 Title/Abstract Full Text View citing articles Show Details
Qualitative Information 1 of 1
Identification Physical Data Spectra
Biological material
domestic cat
Assay Description
Tested for main behavioral changes of cats at a intraventricular dose of 200 microg; None
Citation
Kalir; Edery; Pelah; Balderman; Porath
Journal of medicinal chemistry, 1969 , vol. 12, # 3 p. 473 - 477 Title/Abstract Full Text View citing articles Show Details
Reference (expand all/collapse all) Journal of medicinal che...
Title/Abstract Full Text View citing articles Show Details