Query Query
Results
Date
1 substances in Reaxys
2018-03-04 20h:42m:43s (EST)
N
1. Query
O
O
Search as: As drawn
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1/17
2018-03-04 20:50:08
Reaxys ID 10098853 View in Reaxys
1/1 Chemical Name: JWH 250; 2-(2-methoxy-phenyl)-1-(1-pentyl-1H-indol-3-yl)-ethanone; 1-(1-pentyl-1H-indol-3-yl)-2-(2-methoxyphenyl)-ethanone; 1-(1-pentyl-1H-indol-3-yl)-2-(2-methoxyphenyl)ethanone; 2-(2-methoxyphenyl)-1-(1-pentyl-1H-indol-3yl)ethanone; 2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone; JWH-250 Linear Structure Formula: C22H25NO2 Molecular Formula: C22H25NO2 Molecular Weight: 335.446 Type of Substance: heterocyclic InChI Key: FFLSJIQJQKDDCM-UHFFFAOYSA-N Note:
N
O
O
Substance Label (2) Label References JWH-250
Wohlfarth, Ariane; Scheidweiler, Karl B; Chen, Xiaohong; Liu, Hua-Fen; Huestis, Marilyn A.; Analytical Chemistry; vol. 85; nb. 7; (2013); p. 3730 - 3738, View in Reaxys; Hruba, Lenka; McMahon, Lance R.; Journal of Pharmacology and Experimental Therapeutics; vol. 362; nb. 2; (2017); p. 278 - 286, View in Reaxys
4, Ar=2-MeOPh, R=H
Huffman, John W.; Szklennik, Paul V.; Almond, Amanda; Bushell, Kristen; Selley, Dana E.; He, Hengjun; Cassidy, Michael P.; Wiley, Jenny L.; Martin, Billy R.; Bioorganic and Medicinal Chemistry Letters; vol. 15; nb. 18; (2005); p. 4110 - 4113, View in Reaxys
Patent-Specific Data (1) Location in Patent References Page/Page column
Patent; Randox Laboratories Ltd.; Fitzgerald, Stephen Peter; Innocenzi, Paul John; Lowry, Philip Andrew; McConnell, Ivan Robert; Benchikh, Elouard; EP2698384; (2014); (A1) English, View in Reaxys
Druglikeness (1) 1 of 1
LogP
5.637
H Bond Donors
0
H Bond Acceptors
2
Rotatable Bonds
8
TPSA
31.23
Lipinski Number
3
Veber Number
2
Highest Clinical Phase (1) Highest Clinical Phase Preclinical Melting Point (1) 1 of 1
Melting Point [°C]
85 - 86
Nycz, Jacek E.; Malecki, Grzegorz; Zawiazalec, Marcin; Pazdziorek, Tadeusz; Skop, Patrycja; Journal of Molecular Structure; vol. 984; nb. 1-3; (2010); p. 125 - 130, View in Reaxys Chromatographic Data (3) Chromatographic References data SFC (Supercritical fluid chromatography)
Toyo'Oka, Toshimasa; Kikura-Hanajiri, Ruri; Chemical and Pharmaceutical Bulletin; vol. 63; nb. 10; (2015); p. 762 - 769, View in Reaxys
GC (Gas chroma- Harris, Dana N.; Hokanson, Stephen; Miller, Vickie; Jackson, Glen P.; International Journal of Mass tography) Spectrometry; vol. 368; (2014); p. 23 - 29, View in Reaxys HPLC (High performance liquid chromatography)
Wohlfarth, Ariane; Scheidweiler, Karl B; Chen, Xiaohong; Liu, Hua-Fen; Huestis, Marilyn A.; Analytical Chemistry; vol. 85; nb. 7; (2013); p. 3730 - 3738, View in Reaxys
Crystal Phase (1) Description (Crys- References tal Phase)
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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2018-03-04 20:50:08
Dimensions of the Nycz, Jacek E.; Malecki, Grzegorz; Zawiazalec, Marcin; Pazdziorek, Tadeusz; Skop, Patrycja; Journal of unit cell Molecular Structure; vol. 984; nb. 1-3; (2010); p. 125 - 130, View in Reaxys Crystal Property Description (2) Colour & Other Location Properties orange
References
Page/Page column
Patent; Randox Laboratories Ltd.; Fitzgerald, Stephen Peter; Innocenzi, Paul John; Lowry, Philip Andrew; McConnell, Ivan Robert; Benchikh, Elouard; EP2698384; (2014); (A1) English, View in Reaxys
colourless
Nycz, Jacek E.; Malecki, Grzegorz; Zawiazalec, Marcin; Pazdziorek, Tadeusz; Skop, Patrycja; Journal of Molecular Structure; vol. 984; nb. 1-3; (2010); p. 125 - 130, View in Reaxys
Crystal System (1) Comment (Crystal References System) Crystal system given
Nycz, Jacek E.; Malecki, Grzegorz; Zawiazalec, Marcin; Pazdziorek, Tadeusz; Skop, Patrycja; Journal of Molecular Structure; vol. 984; nb. 1-3; (2010); p. 125 - 130, View in Reaxys
Interatomic Distances and Angles (1) Description References Interatomic distances and angles
Nycz, Jacek E.; Malecki, Grzegorz; Zawiazalec, Marcin; Pazdziorek, Tadeusz; Skop, Patrycja; Journal of Molecular Structure; vol. 984; nb. 1-3; (2010); p. 125 - 130, View in Reaxys
Space Group (1) Comment (Space Group)
References
Space group(s) given
Nycz, Jacek E.; Malecki, Grzegorz; Zawiazalec, Marcin; Pazdziorek, Tadeusz; Skop, Patrycja; Journal of Molecular Structure; vol. 984; nb. 1-3; (2010); p. 125 - 130, View in Reaxys
NMR Spectroscopy (3) 1 of 3
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
13C
Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]
150
Uchiyama, Nahoko; Kikura-Hanajiri, Ruri; Goda, Yukihiro; Chemical and Pharmaceutical Bulletin; vol. 59; nb. 9; (2011); p. 1203 - 1205, View in Reaxys 2 of 3
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- chloroform-d1 scopy) Temperature (NMR Spectroscopy) [°C]
30
Frequency (NMR Spectroscopy) [MHz]
400.1
Nycz, Jacek E.; Malecki, Grzegorz; Zawiazalec, Marcin; Pazdziorek, Tadeusz; Skop, Patrycja; Journal of Molecular Structure; vol. 984; nb. 1-3; (2010); p. 125 - 130, View in Reaxys 3 of 3
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
13C
Solvents (NMR Spectro- chloroform-d1 scopy)
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Temperature (NMR Spectroscopy) [°C]
30
Frequency (NMR Spectroscopy) [MHz]
100.5
Nycz, Jacek E.; Malecki, Grzegorz; Zawiazalec, Marcin; Pazdziorek, Tadeusz; Skop, Patrycja; Journal of Molecular Structure; vol. 984; nb. 1-3; (2010); p. 125 - 130, View in Reaxys IR Spectroscopy (1) 1 of 1
Description (IR Spectroscopy)
Bands; Spectrum
Solvent (IR Spectroscopy)
potassium bromide
Nycz, Jacek E.; Malecki, Grzegorz; Zawiazalec, Marcin; Pazdziorek, Tadeusz; Skop, Patrycja; Journal of Molecular Structure; vol. 984; nb. 1-3; (2010); p. 125 - 130, View in Reaxys Mass Spectrometry (7) Description (Mass References Spectrometry) tandem mass spectrometry; electrospray ionisation (ESI); spectrum
Toyo'Oka, Toshimasa; Kikura-Hanajiri, Ruri; Chemical and Pharmaceutical Bulletin; vol. 63; nb. 10; (2015); p. 762 - 769, View in Reaxys
time-of-flight Sysoev, Alexey A.; Poteshin, Sergey S.; Chernyshev, Denis M.; Karpov, Alexander V.; Tuzkov, Yuriy B.; mass spectra Kyzmin, Vyacheslav V.; Sysoev, Alexander A.; European Journal of Mass Spectrometry; vol. 20; nb. 2; (TOFMS); electro- (2014); p. 185 - 192, View in Reaxys spray ionisation (ESI); APCI (atmospheric pressure chemical ionization); spectrum electron impact (EI); spectrum
Harris, Dana N.; Hokanson, Stephen; Miller, Vickie; Jackson, Glen P.; International Journal of Mass Spectrometry; vol. 368; (2014); p. 23 - 29, View in Reaxys
electrospray ionisation (ESI); tandem mass spectrometry; liquid chromatography mass spectrometry (LCMS); spectrum
Wohlfarth, Ariane; Scheidweiler, Karl B; Chen, Xiaohong; Liu, Hua-Fen; Huestis, Marilyn A.; Analytical Chemistry; vol. 85; nb. 7; (2013); p. 3730 - 3738, View in Reaxys
MALDI-TOF (Ma- Gottardo, Rossella; Chiarini, Anna; Dal Pra, Ilaria; Seri, Catia; Rimondo, Claudia; Serpelloni, Giovanni; trix assisted laser Armato, Ubaldo; Tagliaro, Franco; Journal of Mass Spectrometry; vol. 47; nb. 1; (2012); p. 141 - 146, desorption ioniza- View in Reaxys tion - time of flight); Spectrum LCMS (Liquid chromatography mass spectrometry); ESI (Electrospray ionisation); IT (ion trap); Tandem mass spectrometry; Spectrum
Hutter; Broecker; Kneisel; Auwaerter; Journal of Mass Spectrometry; vol. 47; nb. 1; (2012); p. 54 - 65, View in Reaxys
LCMS (Liquid chromatography mass spectrometry); Tandem mass spectrometry; QIT (quadru-
Dresen, Sebastian; Kneisel, Stefan; Weinmann, Wolfgang; Zimmermann, Ralf; Auwarter, Volker; Journal of Mass Spectrometry; vol. 46; nb. 2; (2011); p. 163 - 171, View in Reaxys
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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pole ion trap); Spectrum UV/VIS Spectroscopy (1) 1 of 1
Solvent (UV/VIS Spectroscopy)
methanol
Absorption Maxima (UV/ 304; 245.5; 213.5 VIS) [nm] Log epsilon
4.54; 4.5; 4.97
Nycz, Jacek E.; Malecki, Grzegorz; Zawiazalec, Marcin; Pazdziorek, Tadeusz; Skop, Patrycja; Journal of Molecular Structure; vol. 984; nb. 1-3; (2010); p. 125 - 130, View in Reaxys Medchem (22) 1 of 22
Target Name
Cannabinoid receptor 1 [Rattus norvegicus]
Target Synonyms
brain-type cannabinoid receptor; cannabinoid receptor 1; cb-r; cb1; cnr1 (cannabinoid receptor 1); skr6
Target Uniprot ID
p20272
Target, Subunit, Species Cannabinoid receptor 1 [Rattus norvegicus] Target Mutant/Chimera Details
Cannabinoid receptor 1 [Rattus norvegicus]:Wild
Target Species (Bioactivity)
Rattus norvegicus
Target Transfection
Non Transfected
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
Binding
Biological Species/NCBI Sprague Dawley rat ID Organs/Tissues
brain cortex
Cell Fraction
P2 fraction: membrane
Substance RN
10098853View in Reaxys
Substance Name
JWH-250
Measurement Parameter
Ki
Unit
nM
Quantitative value
11
Deviation
2
Measurement pX
7.96
Concomitants: Compound RN
6659789; 6659789
Concomitants: Compound name
CP 55940; [3H]-CP 55940
Concomitants: Compound role
NSB; RAD
Huffman, John W.; Szklennik, Paul V.; Almond, Amanda; Bushell, Kristen; Selley, Dana E.; He, Hengjun; Cassidy, Michael P.; Wiley, Jenny L.; Martin, Billy R.; Bioorganic and Medicinal Chemistry Letters; vol. 15; nb. 18; (2005); p. 4110 - 4113, View in Reaxys 2 of 22
Target Name
Cannabinoid receptor 2 [human]
Target Synonyms
cannabinoid receptor 2; cb-2; cb2; cb2a; cb2b; cnr2; cx5; hcb2
Target Uniprot ID
p34972
Target, Subunit, Species Cannabinoid receptor 2 [human]
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
5/17
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Target Mutant/Chimera Details
Cannabinoid receptor 2 [human]:Wild
Target Species (Bioactivity)
human
Target Transfection
Transfected
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
Binding
Cells/Cell Lines
CHO
Cell Fraction
P2 fraction: membrane
Substance RN
10098853View in Reaxys
Substance Name
JWH-250
Measurement Parameter
Ki
Unit
nM
Quantitative value
33
Deviation
2
Measurement pX
7.48
Concomitants: Compound RN
6659789; 6659789; 2088311
Concomitants: Compound name
CP 55940; [3H]-CP 55940; PMSF
Concomitants: Compound role
NSB; RAD; COM
Huffman, John W.; Szklennik, Paul V.; Almond, Amanda; Bushell, Kristen; Selley, Dana E.; He, Hengjun; Cassidy, Michael P.; Wiley, Jenny L.; Martin, Billy R.; Bioorganic and Medicinal Chemistry Letters; vol. 15; nb. 18; (2005); p. 4110 - 4113, View in Reaxys 3 of 22
Target Name
Cannabinoid receptor 1 [human]
Target Synonyms
cann6; cannabinoid receptor 1; cb-r; cb1; cnr; cnr1 (cannabinoid receptor 1)
Target Uniprot ID
p21554; p21554-3
Target, Subunit, Species Cannabinoid receptor 1 [human] Target Mutant/Chimera Details
Cannabinoid receptor 1 [human]:Wild
Target Species (Bioactivity)
human
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
Binding
Substance RN
10098853View in Reaxys
Substance Name
JWH-250
Substance Dose
0.00300000 µM
Measurement Parameter
IC50
Unit
nM
Quantitative value
260
Measurement pX
6.59
Concomitants: Compound RN
6659789
Concomitants: Compound name
[3H]-CP 55940
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
6/17
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Concomitants: Compound role
RAD
Uchiyama, Nahoko; Kikura-Hanajiri, Ruri; Goda, Yukihiro; Chemical and Pharmaceutical Bulletin; vol. 59; nb. 9; (2011); p. 1203 - 1205, View in Reaxys 4 of 22
Target Name
Cannabinoid receptor 2 [human]
Target Synonyms
cannabinoid receptor 2; cb-2; cb2; cb2a; cb2b; cnr2; cx5; hcb2
Target Uniprot ID
p34972
Target, Subunit, Species Cannabinoid receptor 2 [human] Target Mutant/Chimera Details
Cannabinoid receptor 2 [human]:Wild
Target Species (Bioactivity)
human
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
Binding
Substance RN
10098853View in Reaxys
Substance Name
JWH-250
Substance Dose
0.00300000 µM
Measurement Parameter
IC50
Unit
nM
Quantitative value
103
Measurement pX
6.99
Concomitants: Compound RN
6659789
Concomitants: Compound name
[3H]-CP 55940
Concomitants: Compound role
RAD
Uchiyama, Nahoko; Kikura-Hanajiri, Ruri; Goda, Yukihiro; Chemical and Pharmaceutical Bulletin; vol. 59; nb. 9; (2011); p. 1203 - 1205, View in Reaxys 5 of 22
Target Name
Cannabinoid receptor 1 [Rattus norvegicus]
Target Synonyms
brain-type cannabinoid receptor; cannabinoid receptor 1; cb-r; cb1; cnr1 (cannabinoid receptor 1); skr6
Target Uniprot ID
p20272
Target, Subunit, Species Cannabinoid receptor 1 [Rattus norvegicus] Target Mutant/Chimera Details
Cannabinoid receptor 1 [Rattus norvegicus]:Wild
Target Species (Bioactivity)
Rattus norvegicus
Substance Action on Target
Radioligand (/ligand)
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Binding affinity of the compound towards rat cannabinoid receptor 1 in brain homogenates
Biological Species/NCBI Rattus norvegicus ID Substance RN
10098853View in Reaxys
Measurement Parameter
pKi
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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6 of 22
Quantitative value
7.958
Measurement pX
7.96
Target Name
Cannabinoid receptor 1 [Rattus norvegicus]
Target Synonyms
brain-type cannabinoid receptor; cannabinoid receptor 1; cb-r; cb1; cnr1 (cannabinoid receptor 1); skr6
Target Uniprot ID
p20272
Target, Subunit, Species Cannabinoid receptor 1 [Rattus norvegicus] Target Mutant/Chimera Details
Cannabinoid receptor 1 [Rattus norvegicus]:Wild
Target Species (Bioactivity)
Rattus norvegicus
Substance Action on Target
Radioligand (/ligand)
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Ratio of binding affinity of the compound towards rat brain homogenate cannabinoid receptor 1 to that of cloned human cannabinoid receptor 2
Biological Species/NCBI Rattus norvegicus ID
7 of 22
Substance RN
10098853View in Reaxys
Measurement Parameter
Ratio
Quantitative value
1.064
Target Name
Cannabinoid receptor 2 [human]
Target Synonyms
cannabinoid receptor 2; cb-2; cb2; cb2a; cb2b; cnr2; cx5; hcb2
Target Uniprot ID
p34972
Target, Subunit, Species Cannabinoid receptor 2 [human] Target Mutant/Chimera Details
Cannabinoid receptor 2 [human]:Wild
Target Species (Bioactivity)
human
Substance Action on Target
Radioligand (/ligand)
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Binding affinity of the compound towards cloned human cannabinoid receptor 2 was determined
Biological Species/NCBI human ID
8 of 22
Substance RN
10098853View in Reaxys
Measurement Parameter
pKi
Quantitative value
7.481
Measurement pX
7.48
Target Name
Cannabinoid receptor 2 [human]
Target Synonyms
cannabinoid receptor 2; cb-2; cb2; cb2a; cb2b; cnr2; cx5; hcb2
Target Uniprot ID
p34972
Target, Subunit, Species Cannabinoid receptor 2 [human] Target Mutant/Chimera Details
Cannabinoid receptor 2 [human]:Wild
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
8/17
2018-03-04 20:50:08
Target Species (Bioactivity)
human
Substance Action on Target
Radioligand (/ligand)
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Binding affinity of the compound towards human cannabinoid receptor 2 expressed in CHO membranes using 102.9 Ci/mmol [3H]CP 55940 as radioligand upon incubation in 50 mM Tris-HCl, pH 7.4 for 1 h at 30 degree C
Biological Species/NCBI human ID
9 of 22
Cells/Cell Lines
CHO
Substance RN
10098853View in Reaxys
Qualitative Results
Ki not calculated
Measurement Parameter
Qualitative
Measurement Object
Ki
Concomitants: Compound name
[3H]CP 55940
Concomitants: Compound role
RAD
Target Name
Cannabinoid receptor 2 [human]
Target Synonyms
cannabinoid receptor 2; cb-2; cb2; cb2a; cb2b; cnr2; cx5; hcb2
Target Uniprot ID
p34972
Target, Subunit, Species Cannabinoid receptor 2 [human] Target Mutant/Chimera Details
Cannabinoid receptor 2 [human]:Wild
Target Species (Bioactivity)
human
Substance Action on Target
Radioligand (/ligand)
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Negative logarithm of binding affinity of the compound towards human cannabinoid receptor 2 expressed in CHO membranes using 102.9 Ci/mmol [3H]CP 55940 as radioligand upon incubation in 50 mM Tris-HCl, pH 7.4 for 1 h at 30 degree C
Biological Species/NCBI human ID
10 of 22
Cells/Cell Lines
CHO
Substance RN
10098853View in Reaxys
Measurement Parameter
pKi
Quantitative value
7.481
Measurement pX
7.48
Concomitants: Compound name
[3H]CP 55940
Concomitants: Compound role
RAD
Target Name
Cannabinoid receptor 1 [human]
Target Synonyms
cann6; cannabinoid receptor 1; cb-r; cb1; cnr; cnr1 (cannabinoid receptor 1)
Target Uniprot ID
p21554; p21554-3
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
9/17
2018-03-04 20:50:08
Target, Subunit, Species Cannabinoid receptor 1 [human] Target Mutant/Chimera Details
Cannabinoid receptor 1 [human]:Wild
Target Species (Bioactivity)
human
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Ratio of inhibitory concentration of compound towards human recombinant cannabinoid receptor-1 to that of cannabinoid receptor-2 using [3H]CP-55940 as radioligand was determined
Biological Species/NCBI human ID Substance RN
10098853View in Reaxys
Measurement Parameter
Qualitative
Qualitative value
Not Published
Concomitants: Compound name
[3H]CP-55940
Concomitants: Compound role
RAD
Uchiyama, Nahoko; Kikura-Hanajiri, Ruri; Goda, Yukihiro; Chemical and Pharmaceutical Bulletin; vol. 59; nb. 9; (2011); p. 1203 - 1205, View in Reaxys 11 of 22
Target Name
Cannabinoid receptor type 1 [rhesus monkey]
Target Synonyms
cannabinoid receptor type 1
Target, Subunit, Species Cannabinoid receptor type 1 [rhesus monkey] Target Mutant/Chimera Details
Cannabinoid receptor type 1 [rhesus monkey]:Wild
Target Species (Bioactivity)
rhesus monkey
Target Transfection
Non Transfected
Bioassay Category
In Vivo (Animal models)
Biological Species/NCBI rhesus monkey ID Substance RN
10098853View in Reaxys
Substance Name
2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone
Substance Dose
0.1 mg/kg
Substance Route of Adm.
intravenous administration
Measurement Parameter
% change
Measurement Object
rate of response
Qualitative value
Not active
Measurement pX
1
Concomitants: Compound RN
4354308
Concomitants: Compound name
Δ%9&-tetrahydrocannabinol
Concomitants: Compound role
COM
Hruba, Lenka; McMahon, Lance R.; Journal of Pharmacology and Experimental Therapeutics; vol. 362; nb. 2; (2017); p. 278 - 286, View in Reaxys
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
10/17
2018-03-04 20:50:08
12 of 22
Target Name
Cannabinoid receptor type 1 [rhesus monkey]
Target Synonyms
cannabinoid receptor type 1
Target, Subunit, Species Cannabinoid receptor type 1 [rhesus monkey] Target Mutant/Chimera Details
Cannabinoid receptor type 1 [rhesus monkey]:Wild
Target Species (Bioactivity)
rhesus monkey
Target Transfection
Non Transfected
Bioassay Category
In Vivo (Animal models)
Biological Species/NCBI rhesus monkey ID Substance RN
10098853View in Reaxys
Substance Name
2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone
Substance Dose
0.1 mg/kg
Substance Route of Adm.
intravenous administration
Measurement Parameter
Time
Unit
h
Measurement Object
of action
Quantitative value
1-2
Concomitants: Compound RN
4354308
Concomitants: Compound name
Δ%9&-tetrahydrocannabinol
Concomitants: Compound role
COM
Hruba, Lenka; McMahon, Lance R.; Journal of Pharmacology and Experimental Therapeutics; vol. 362; nb. 2; (2017); p. 278 - 286, View in Reaxys 13 of 22
Target Name
Cannabinoid receptor type 1 [rhesus monkey]
Target Synonyms
cannabinoid receptor type 1
Target, Subunit, Species Cannabinoid receptor type 1 [rhesus monkey] Target Mutant/Chimera Details
Cannabinoid receptor type 1 [rhesus monkey]:Wild
Target Species (Bioactivity)
rhesus monkey
Target Transfection
Non Transfected
Bioassay Category
In Vivo (Animal models)
Biological Species/NCBI rhesus monkey ID Substance RN
10098853View in Reaxys
Substance Name
2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone
Substance Dose
0.001 - 0.1 mg/kg
Substance Route of Adm.
intravenous administration
Measurement Parameter
ED50
Unit
mg/kg
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
11/17
2018-03-04 20:50:08
Quantitative value
0.033
Concomitants: Compound RN
4354308
Concomitants: Compound name
Δ%9&-tetrahydrocannabinol
Concomitants: Compound role
COM
Hruba, Lenka; McMahon, Lance R.; Journal of Pharmacology and Experimental Therapeutics; vol. 362; nb. 2; (2017); p. 278 - 286, View in Reaxys 14 of 22
Target Name
Cannabinoid receptor type 1 [rhesus monkey]
Target Synonyms
cannabinoid receptor type 1
Target, Subunit, Species Cannabinoid receptor type 1 [rhesus monkey] Target Mutant/Chimera Details
Cannabinoid receptor type 1 [rhesus monkey]:Wild
Target Species (Bioactivity)
rhesus monkey
Target Transfection
Non Transfected
Bioassay Category
In Vivo (Animal models)
Biological Species/NCBI rhesus monkey ID Substance RN
10098853View in Reaxys
Substance Name
2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone
Substance Dose
0.001 - 1 mg/kg
Substance Route of Adm.
intravenous administration
Measurement Parameter
ED50
Unit
mg/kg
Quantitative value
0.517
Concomitants: Compound RN
4354308
Concomitants: Compound name
Δ%9&-tetrahydrocannabinol
Concomitants: Compound role
COM
Hruba, Lenka; McMahon, Lance R.; Journal of Pharmacology and Experimental Therapeutics; vol. 362; nb. 2; (2017); p. 278 - 286, View in Reaxys 15 of 22
Target Name
Cannabinoid receptor type 1 [rhesus monkey]
Target Synonyms
cannabinoid receptor type 1
Target, Subunit, Species Cannabinoid receptor type 1 [rhesus monkey] Target Mutant/Chimera Details
Cannabinoid receptor type 1 [rhesus monkey]:Wild
Target Species (Bioactivity)
rhesus monkey
Target Transfection
Non Transfected
Bioassay Category
In Vivo (Animal models)
Biological Species/NCBI rhesus monkey ID Substance RN
10098853View in Reaxys
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
12/17
2018-03-04 20:50:08
Substance Name
2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone
Substance Dose
0.001 - 1 mg/kg
Substance Route of Adm.
intravenous administration
Measurement Parameter
pKb
Unit
no unit
Quantitative value
6.83
Measurement pX
6.83
Concomitants: Compound RN
4354308
Concomitants: Compound name
Δ%9&-tetrahydrocannabinol
Concomitants: Compound role
COM
Hruba, Lenka; McMahon, Lance R.; Journal of Pharmacology and Experimental Therapeutics; vol. 362; nb. 2; (2017); p. 278 - 286, View in Reaxys 16 of 22
Target Name
Cannabinoid receptor type 1 [rhesus monkey]
Target Synonyms
cannabinoid receptor type 1
Target, Subunit, Species Cannabinoid receptor type 1 [rhesus monkey] Target Mutant/Chimera Details
Cannabinoid receptor type 1 [rhesus monkey]:Wild
Target Species (Bioactivity)
rhesus monkey
Target Transfection
Non Transfected
Bioassay Category
In Vivo (Animal models)
Biological Species/NCBI rhesus monkey ID Substance RN
10098853View in Reaxys
Substance Name
2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone
Substance Dose
0.001 - 1 mg/kg
Substance Route of Adm.
intravenous administration
Measurement Parameter
% change
Measurement Object
rate of response
Qualitative value
Not active
Measurement pX
1
Concomitants: Compound RN
4354308
Concomitants: Compound name
Δ%9&-tetrahydrocannabinol
Concomitants: Compound role
COM
Hruba, Lenka; McMahon, Lance R.; Journal of Pharmacology and Experimental Therapeutics; vol. 362; nb. 2; (2017); p. 278 - 286, View in Reaxys 17 of 22
Target Name
Cannabinoid receptor type 1 [rhesus monkey]
Target Synonyms
cannabinoid receptor type 1
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
13/17
2018-03-04 20:50:08
Target, Subunit, Species Cannabinoid receptor type 1 [rhesus monkey] Target Mutant/Chimera Details
Cannabinoid receptor type 1 [rhesus monkey]:Wild
Target Species (Bioactivity)
rhesus monkey
Target Transfection
Non Transfected
Bioassay Category
In Vivo (Animal models)
Biological Species/NCBI rhesus monkey ID Substance RN
10098853View in Reaxys
Substance Name
2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone
Substance Dose
0.001 - 1 mg/kg
Substance Route of Adm.
intravenous administration
Measurement Parameter
% increase
Measurement Object
Drug-lever responding
Qualitative value
Active
Concomitants: Compound RN
4354308
Concomitants: Compound name
Δ%9&-tetrahydrocannabinol
Concomitants: Compound role
COM
Hruba, Lenka; McMahon, Lance R.; Journal of Pharmacology and Experimental Therapeutics; vol. 362; nb. 2; (2017); p. 278 - 286, View in Reaxys 18 of 22
Target Name
Cannabinoid receptor type 1 [rhesus monkey]
Target Synonyms
cannabinoid receptor type 1
Target, Subunit, Species Cannabinoid receptor type 1 [rhesus monkey] Target Mutant/Chimera Details
Cannabinoid receptor type 1 [rhesus monkey]:Wild
Target Species (Bioactivity)
rhesus monkey
Target Transfection
Non Transfected
Bioassay Category
In Vivo (Animal models)
Biological Species/NCBI rhesus monkey ID Substance RN
10098853View in Reaxys
Substance Name
2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone
Substance Dose
1 mg/kg
Substance Route of Adm.
intravenous administration
Measurement Parameter
ED50
Unit
mg/kg
Quantitative value
0.56
Concomitants: Compound RN
4354308; 7231571
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
14/17
2018-03-04 20:50:08
Concomitants: Compound name
Δ%9&-tetrahydrocannabinol; rimonabant
Concomitants: Compound role
AGO; COM
Hruba, Lenka; McMahon, Lance R.; Journal of Pharmacology and Experimental Therapeutics; vol. 362; nb. 2; (2017); p. 278 - 286, View in Reaxys 19 of 22
Target Name
Cannabinoid receptor type 1 [rhesus monkey]
Target Synonyms
cannabinoid receptor type 1
Target, Subunit, Species Cannabinoid receptor type 1 [rhesus monkey] Target Mutant/Chimera Details
Cannabinoid receptor type 1 [rhesus monkey]:Wild
Target Species (Bioactivity)
rhesus monkey
Target Transfection
Non Transfected
Bioassay Category
In Vivo (Animal models)
Biological Species/NCBI rhesus monkey ID Substance RN
10098853View in Reaxys
Substance Name
2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone
Substance Dose
3.2 mg/kg
Substance Route of Adm.
intravenous administration
Measurement Parameter
ED50
Unit
mg/kg
Quantitative value
2.21
Concomitants: Compound RN
4354308; 7231571
Concomitants: Compound name
Δ%9&-tetrahydrocannabinol; rimonabant
Concomitants: Compound role
AGO; COM
Hruba, Lenka; McMahon, Lance R.; Journal of Pharmacology and Experimental Therapeutics; vol. 362; nb. 2; (2017); p. 278 - 286, View in Reaxys 20 of 22
Target Name
Cannabinoid receptor type 1 [rhesus monkey]
Target Synonyms
cannabinoid receptor type 1
Target, Subunit, Species Cannabinoid receptor type 1 [rhesus monkey] Target Mutant/Chimera Details
Cannabinoid receptor type 1 [rhesus monkey]:Wild
Target Species (Bioactivity)
rhesus monkey
Target Transfection
Non Transfected
Bioassay Category
In Vivo (Animal models)
Biological Species/NCBI rhesus monkey ID Substance RN
10098853View in Reaxys
Substance Name
2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone
Substance Dose
3.2 mg/kg
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
15/17
2018-03-04 20:50:08
Substance Route of Adm.
intravenous administration
Measurement Parameter
%
Unit
%
Measurement Object
response rate
Quantitative value
15
Concomitants: Compound RN
4354308; 7231571
Concomitants: Compound name
Δ%9&-tetrahydrocannabinol; rimonabant
Concomitants: Compound role
AGO; COM
Hruba, Lenka; McMahon, Lance R.; Journal of Pharmacology and Experimental Therapeutics; vol. 362; nb. 2; (2017); p. 278 - 286, View in Reaxys 21 of 22
Target Name
Cannabinoid receptor type 1 [rhesus monkey]
Target Synonyms
cannabinoid receptor type 1
Target, Subunit, Species Cannabinoid receptor type 1 [rhesus monkey] Target Mutant/Chimera Details
Cannabinoid receptor type 1 [rhesus monkey]:Wild
Target Species (Bioactivity)
rhesus monkey
Target Transfection
Non Transfected
Bioassay Category
In Vivo (Animal models)
Biological Species/NCBI rhesus monkey ID Substance RN
10098853View in Reaxys
Substance Name
2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone
Substance Dose
0.1 mg/kg
Substance Route of Adm.
intravenous administration
Measurement Parameter
%
Unit
%
Measurement Object
Drug-lever responding
Quantitative value
100
Concomitants: Compound RN
4354308
Concomitants: Compound name
Δ%9&-tetrahydrocannabinol
Concomitants: Compound role
COM
Hruba, Lenka; McMahon, Lance R.; Journal of Pharmacology and Experimental Therapeutics; vol. 362; nb. 2; (2017); p. 278 - 286, View in Reaxys 22 of 22
Target Name
Cannabinoid receptor type 1 [rhesus monkey]
Target Synonyms
cannabinoid receptor type 1
Target, Subunit, Species Cannabinoid receptor type 1 [rhesus monkey] Target Mutant/Chimera Details
Cannabinoid receptor type 1 [rhesus monkey]:Wild
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
16/17
2018-03-04 20:50:08
Target Species (Bioactivity)
rhesus monkey
Target Transfection
Non Transfected
Bioassay Category
In Vivo (Animal models)
Biological Species/NCBI rhesus monkey ID Substance RN
10098853View in Reaxys
Substance Name
2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone
Substance Dose
1 mg/kg
Substance Route of Adm.
intravenous administration
Measurement Parameter
%
Unit
%
Measurement Object
Drug-lever responding
Quantitative value
0
Concomitants: Compound RN
4354308; 7231571
Concomitants: Compound name
Δ%9&-tetrahydrocannabinol; rimonabant
Concomitants: Compound role
AGO; COM
Hruba, Lenka; McMahon, Lance R.; Journal of Pharmacology and Experimental Therapeutics; vol. 362; nb. 2; (2017); p. 278 - 286, View in Reaxys
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
17/17
2018-03-04 20:50:08