Reaxys
PubChem
eMolecules
LabNetwork
Bioactivities (80)
SigmaAldrich
Reactions (11)
Substances (12)
Structure
Targets (2)
Citations (40)
Structure/Compound Data Chemical Name: 1-(4-methylphenyl)-2-methylaminopropan-1-one Reaxys Registry Number: 2717770
Type of Substance: isocyclic Molecular Formula: C11H15NO Linear Structure Formula: C11H15NO Molecular Weight: 177.246
InChI Key: YELGFTGWJGBAQU-UHFFFAOYSA-N
N° of preparations All Preps | All Reactions 3 prep out of 5 reactions.
1
Synthesize | Hide Details Find similar Chemical Names and Synonyms 1-(4-methylphenyl)-2-methylaminopropan-1-one, 2-methylamino-1-(4-methylphenyl)propan-1-one, 2-(methylamino)-1-(p-tolyl)propan-1-one, 4methyl-N-methylcathinone, 4-methylmethcathinone, mephedrone, 2-(methylamino)-1-(4-methylphenyl)propan-1-one Druglikeness Bioactivity In vivo: Animal Model (2) Qualitative Information 1 of 2
Biological material
Rattus norvegicus
Assay
Effect : neurotransmitter level
Available Data
Target
N° of ref.
Druglikeness
Bioactivity
Identification Physical Data (4) Spectra (12)
Show Targets
29
2 of 2
Description
Target : ;nucleus accumbens Species : Sprague-Dawley rat microdialysis
Results
dopamine extracellular level increase rate 295 - 496 percent
Citation
Kehr; Ichinose; Yoshitake; Goiny; Sievertsson; Nyberg
British Journal of Pharmacology, 2011 , vol. 164, # 8 p. 1949 - 1958 Title/Abstract Full Text View citing articles Show Details
Biological material
Rattus norvegicus
Assay Description
Effect : neurotransmitter metabolite level Target : ;nucleus accumbens Species : Sprague-Dawley rat microdialysis; DOPAC: 3,4-dihydroxyphenylacetic acid; 5-HIAA: 5-hydroxyindolacetic acid
Results
DOPAC extracellular level decrease rate 23.3 percent
Citation
Kehr; Ichinose; Yoshitake; Goiny; Sievertsson; Nyberg
British Journal of Pharmacology, 2011 , vol. 164, # 8 p. 1949 - 1958 Title/Abstract Full Text View citing articles Show Details
Metabolism (4) Quantitative Results pX
Parameter
Value (qual)
fu
Value (quant)
Unit
Action on Target
Target
0.04
Tissue/Organ
Cell plasma cell
Cell fraction
Substrate /Carried Molecule
Dose
Reference (expand all/collapse all) Journal of Medicinal Che...
Title/Abstract Full Text View citing articles Show Details
Zhang, Lei; Villalobos, Anabella; Beck, Elizabeth M.; Bocan, Thomas; Chappie, Thomas A.; Chen, Laigao; Grimwood, Sarah; Heck, Steven D.; Helal, Christopher J.; Hou, Xinjun; Humphrey, John M.; Lu, Jiemin; Skaddan, Marc B.; McCarthy, Timothy J.; Verhoest, Patrick R.; Wager, Travis T.; Zasadny, Kenneth
Journal of Medicinal Chemistry, 2013 , vol. 56, # 11 p. 4568 - 4579 Title/Abstract Full Text View citing articles Show Details
fu
0.02
Journal of Medicinal Che...
Title/Abstract Full Text View citing articles Show Details
Zhang, Lei; Villalobos, Anabella; Beck, Elizabeth M.; Bocan, Thomas; Chappie, Thomas A.; Chen, Laigao; Grimwood, Sarah; Heck, Steven D.; Helal, Christopher J.; Hou, Xinjun; Humphrey, John M.; Lu, Jiemin; Skaddan, Marc B.; McCarthy, Timothy J.; Verhoest, Patrick R.; Wager, Travis T.; Zasadny, Kenneth
Journal of Medicinal Chemistry, 2013 , vol. 56, # 11 p. 4568 - 4579 Title/Abstract Full Text View citing articles Show Details
Qualitative Information 1 of 2
2 of 2
Biological material
RRCK cell line
Assay Description
In vitro apparent permeability of [11C] radiolabelled compound from apical to basolateral direction across RRCK cells
Results
UOM not given
Citation
Zhang, Lei; Villalobos, Anabella; Beck, Elizabeth M.; Bocan, Thomas; Chappie, Thomas A.; Chen, Laigao; Grimwood, Sarah; Heck, Steven D.; Helal, Christopher J.; Hou, Xinjun; Humphrey, John M.; Lu, Jiemin; Skaddan, Marc B.; McCarthy, Timothy J.; Verhoest, Patrick R.; Wager, Travis T.; Zasadny, Kenneth
Journal of Medicinal Chemistry, 2013 , vol. 56, # 11 p. 4568 - 4579 Title/Abstract Full Text View citing articles Show Details
Biological
MDCK-MDR1 cell line
material Assay Description
Ratio of permeability of [11C] radiolabelled compound from basolateral to apical direction to that of apical to basolateral direction across MDCK/MDR-1 cells
Citation
Zhang, Lei; Villalobos, Anabella; Beck, Elizabeth M.; Bocan, Thomas; Chappie, Thomas A.; Chen, Laigao; Grimwood, Sarah; Heck, Steven D.; Helal, Christopher J.; Hou, Xinjun; Humphrey, John M.; Lu, Jiemin; Skaddan, Marc B.; McCarthy, Timothy J.; Verhoest, Patrick R.; Wager, Travis T.; Zasadny, Kenneth
Journal of Medicinal Chemistry, 2013 , vol. 56, # 11 p. 4568 - 4579 Title/Abstract Full Text View citing articles Show Details
Pharmacokinetic (24) Quantitative Results pX
Parameter
Value (qual)
Value (quant)
Unit
MRT
0.16
h
Biological Species
Route of administration
Dose
Sprague Dawley rat
oral administration
30 mg/kg
Dosing regimen
Population
Reference (expand all/collapse all)
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
MRT
0.16
h
Sprague Dawley rat
oral administration
60 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
MAT
4.14
h
Sprague Dawley rat
oral administration
30 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
MAT
4.14
h
Sprague Dawley rat
oral administration
60 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
Vmax
8000
μg/h
Sprague Dawley rat
oral administration
60 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
Vmax
116.22
μg/h
Sprague Dawley rat
oral administration
30 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
Cmax
331.2
ng/ml
Sprague Dawley rat
oral administration
30 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
Cmax
960
ng/ml
Sprague Dawley rat
oral administration
60 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
Tmax
0.93
h
Sprague Dawley rat
oral administration
30 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
Tmax
0.43
h
Sprague Dawley rat
oral administration
60 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
AUC
895.43
ng*h/ml
Sprague Dawley rat
oral administration
60 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
AUC
294.48
ng*h/ml
Sprague Dawley rat
oral administration
30 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
AUC
887.12
ng*h/ml
Sprague Dawley rat
oral administration
60 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
AUC
294.37
ng*h/ml
Sprague Dawley rat
oral administration
30 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
t1/2 abs
3.14
h
Sprague Dawley rat
oral administration
60 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
t1/2 abs
2.15
h
Sprague Dawley rat
oral administration
30 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
t1/2 beta
0.12
h
Sprague Dawley rat
oral administration
30 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
t1/2 beta
0.12
h
Sprague Dawley rat
oral administration
60 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
30 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
60 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
Tlag
0.41
h
Sprague Dawley rat
oral administration
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
Tlag
0.41
h
Sprague Dawley rat
oral administration
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
pX
Parameter F(%)
Value (qual)
Value (quant)
Unit
11.2
%
Biological Species
Route of administration
Dose
Sprague Dawley rat
oral administration
60 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
30 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
30 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
60 mg/kg
Psychopharmacology, 2013...
Title/Abstract Full Text View citing articles Show Details
Dosing regimen
Population
Reference (expand all/collapse all)
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
F(%)
7.3
%
Sprague Dawley rat
oral administration
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
Clm
1298.05
ml/h
Sprague Dawley rat
oral administration
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
Clm
377.79
ml/h
Sprague Dawley rat
oral administration
Martínez-Clemente; López-Arnau; Carbó; Pubill; Camarasa; Escubedo
Psychopharmacology, 2013 , vol. 230, # 1 p. 149 - 149 Title/Abstract Full Text View citing articles Show Details
Identification Physical Data Spectra Chemical Name: 4-methylmethcathinone
1 prep out of 1 reactions.
Druglikeness
Bioactivity
Identification
Show Targets
5
Reaxys Registry Number: 27128336
CAS Registry Number: 1388142-32-2 Molecular Formula: C11H15NO Linear Structure Formula: C11H15NO Molecular Weight: 177.246
InChI Key: YELGFTGWJGBAQU-VIFPVBQESA-N 2
Synthesize | Hide Details Find similar Chemical Names and Synonyms 4-methylmethcathinone, S-mephedrone, mephedrone, S-MEPH, MEPH Druglikeness Bioactivity In vivo: Animal Model (6) Quantitative Results pX
Parameter
Value (qual)
ED50
Value (quant)
Unit
0.56
mg/kg
Action on Target
Animal Model
Biological Species
Route of administration
Dose
Sprague Dawley rat
intraperitoneal administration
2 mg/kg
Psychopharmacology, 2016...
Title/Abstract Full Text View citing articles Show Details
Sprague Dawley rat
intraperitoneal administration
2 mg/kg
Psychopharmacology, 2016...
Title/Abstract Full Text View citing articles Show Details
Sprague Dawley rat
intravenous drug administration
0.25 0.5 mg/kg
Dosing regimen
Effect
Reference (expand all/collapse all)
Harvey, Eric L.; Baker, Lisa E.
Psychopharmacology, 2016 , vol. 233, # 4 p. 673 - 680 Title/Abstract Full Text View citing articles Show Details
ED50
0.22
mg/kg
Harvey, Eric L.; Baker, Lisa E.
Psychopharmacology, 2016 , vol. 233, # 4 p. 673 - 680 Title/Abstract Full Text View citing articles Show Details
% increase
Active
Selfadministration
addictive
ACS Chemical Neuroscienc...
Title/Abstract Full Text View citing articles Show Details
Philogene-Khalid, Helene L.; Simmons, Steven J.; Nayak, Sunil; Martorana, Rose M.; Su, Shu H.; Caro, Yohanka; Ranieri, Brona; Difurio, Kathryn; Mo, Lili; Gentile, Taylor A.; Murad, Ali; Reitz, Allen B.; Muschamp, John W.; Rawls, Scott M.
ACS Chemical Neuroscience, 2017 , vol. 8, # 12 p. 2648 - 2654 Title/Abstract Full Text View citing articles Show Details
1
% increase
Not active
Sprague Dawley rat
intravenous drug administration
0.5 2 mg/kg
Selfadministration
addictive
ACS Chemical Neuroscienc...
Title/Abstract Full Text View citing articles Show Details
Philogene-Khalid, Helene L.; Simmons, Steven J.; Nayak, Sunil; Martorana, Rose M.; Su, Shu H.; Caro, Yohanka; Ranieri, Brona; Difurio, Kathryn; Mo, Lili; Gentile, Taylor A.; Murad, Ali; Reitz, Allen B.; Muschamp, John W.; Rawls, Scott M.
ACS Chemical Neuroscience, 2017 , vol. 8, # 12 p. 2648 - 2654 Title/Abstract Full Text View citing articles Show Details
Qualitative Information 1 of 2
Biological material
Sprague Dawley rat
Citation
Harvey, Eric L.; Baker, Lisa E.
Psychopharmacology, 2016 , vol. 233, # 4 p. 673 - 680 Title/Abstract Full Text View citing articles Show Details
2 of 2
Biological material
Sprague Dawley rat
Citation
Harvey, Eric L.; Baker, Lisa E.
Psychopharmacology, 2016 , vol. 233, # 4 p. 673 - 680 Title/Abstract Full Text View citing articles Show Details
Identification Chemical Name: R-mephedrone Reaxys Registry Number: 27128365
CAS Registry Number: 1388142-31-1 Molecular Formula: C11H15NO Linear Structure Formula: C11H15NO Molecular Weight: 177.246
InChI Key: YELGFTGWJGBAQU-SECBINFHSA-N
1 prep out of 1 reactions.
Druglikeness
Bioactivity
Identification
Show Targets
2
3
Synthesize | Hide Details Find similar Chemical Names and Synonyms R-mephedrone, mephedrone, R-MEPH Druglikeness Bioactivity In vivo: Animal Model (2) Quantitative Results pX
Parameter
1
% increase
Value (qual) Not active
Value (quant)
Unit
Action on Target
Animal Model
Biological Species
Route of administration
Sprague Dawley rat
intravenous drug administration
Dose
Dosing regimen
0.5 mg/kg
Selfadministration
Effect
Reference (expand all/collapse all)
addictive
ACS Chemical Neuroscienc...
Title/Abstract Full Text View citing articles Show Details
Philogene-Khalid, Helene L.; Simmons, Steven J.; Nayak, Sunil; Martorana, Rose M.; Su, Shu H.; Caro, Yohanka; Ranieri, Brona; Difurio, Kathryn; Mo, Lili; Gentile, Taylor A.; Murad, Ali; Reitz, Allen B.; Muschamp, John W.; Rawls, Scott M.
ACS Chemical Neuroscience, 2017 , vol. 8, # 12 p. 2648 - 2654 Title/Abstract Full Text View citing articles Show Details
% increase
Active
Sprague Dawley rat
intravenous drug administration
0.5 mg/kg
Selfadministration
addictive
ACS Chemical Neuroscienc...
Title/Abstract Full Text View citing articles Show Details
Philogene-Khalid, Helene L.; Simmons, Steven J.; Nayak, Sunil; Martorana, Rose M.; Su, Shu H.; Caro, Yohanka; Ranieri, Brona; Difurio, Kathryn; Mo, Lili; Gentile, Taylor A.; Murad, Ali; Reitz, Allen B.; Muschamp, John W.; Rawls, Scott M.
ACS Chemical Neuroscience, 2017 , vol. 8, # 12 p. 2648 - 2654 Title/Abstract Full Text View citing articles Show Details
Identification Chemical Name: 1-(4-methylphenyl)-N-methyl-1-oxopropan-2-aminium chloridum Reaxys Registry Number: 3699980
4 prep out of 5 reactions.
Druglikeness
Bioactivity
Identification Physical Data (13)
Show Targets
10
Type of Substance: isocyclic Molecular Formula: C11H15NO*ClH Linear Structure Formula: C11H15NO*ClH Molecular Weight: 213.707
InChI Key: DLQZFTUKJGRPLZ-UHFFFAOYSA-N
4
Spectra (18)
Synthesize | Hide Details Find similar Chemical Names and Synonyms 1-(4-methylphenyl)-N-methyl-1-oxopropan-2-aminium chloridum, (rac)-2-methylamino-1-(p-tolyl)propan-1-one hydrochloride, 2-aminomethyl-1tolyl-propan-1-one hydrochloride, (±)-4-methylmethcathinone hydrochloride, 4-methylmethcathinone hydrochloride, (±)-mephedrone hydrochloride, 4-methylmecathinone hydrochloride Druglikeness Bioactivity In vitro: Efficacy (2) Quantitative Results pX
Parameter
7.51
EC50
Value (qual)
Value (quant)
Unit
Action on Target
31.07
nM
Stimulator
Target
Tissue/Organ
Sodiumdependent dopamine transporter:Wild
neostriatum
Cell
Bioassay
Dose
Effect
Reference (expand all/collapse all) British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
5.83
EC50
1.47
μM
Stimulator
Sodiumdependent serotonin transporter:Wild
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
brain
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
In vivo: Animal Model (2) Quantitative Results pX
Parameter
Value (qual)
% increase
Moderate
Value (quant)
Unit
Action on Target
Animal Model
Biological Species
Route of administration
Dose
Sprague Dawley rat
intravenous administration
20 mg/kg
Dosing regimen
Effect
Reference (expand all/collapse all) British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
Qualitative Information 1 of 1
Assay Description
Citation
German, Christopher L.; Hoonakker, Amanda H.; Fleckenstein, Annette E.; Hanson, Glen R.
Journal of Neurochemistry, 2014 , vol. 130, # 3 p. 402 - 407 Title/Abstract Full Text View citing articles Show Details
Identification Physical Data Spectra Chemical Name: (S)-4-methylmethcathinone hydrochloride
1 prep out of 1 reactions.
Reaxys Registry Number: 28388619
Molecular Formula: C11H15NO*ClH Linear Structure Formula: C11H15NO*ClH Molecular Weight: 213.707
InChI Key: DLQZFTUKJGRPLZ-FVGYRXGTSA-N
Druglikeness
Bioactivity
Identification Physical Data (3) Spectra (3)
Show Targets
5
Synthesize | Hide Details Find similar Chemical Names and Synonyms (S)-4-methylmethcathinone hydrochloride, mephedrone hydrochloride Druglikeness Bioactivity In vitro: Efficacy (2) Quantitative Results pX
Parameter
7.13
EC50
Value (qual)
Value (quant)
Unit
Action on Target
74.23
nM
Stimulator
Target
Tissue/Organ
Sodiumdependent dopamine transporter:Wild
neostriatum
Cell
Bioassay
Dose
Effect
Reference (expand all/collapse all) British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
7.22
EC50
60.91
nM
Stimulator
Sodiumdependent serotonin transporter:Wild
brain
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
In vivo: Animal Model (17) Quantitative Results pX
Parameter
1
% increase
Value (qual) Not active
Value (quant)
Unit
Action on Target
Animal Model
Biological Species
Route of administration
Dose
Sprague Dawley rat
intravenous administration
15 mg/kg
Dosing regimen Repeated
Effect
Reference (expand all/collapse all) British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
1
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
Low
Sprague Dawley rat
intravenous administration
5 mg/kg
Single
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
Low
Sprague Dawley rat
intravenous administration
10 mg/kg
Single
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
Low
Sprague Dawley rat
intravenous administration
20 mg/kg
Single
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
Low
Sprague Dawley rat
intravenous administration
30 mg/kg
Single
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
1
% increase
Not active
Sprague Dawley rat
intravenous administration
15 mg/kg
Repeated
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
Moderate
Sprague Dawley rat
intravenous administration
5 mg/kg
Single
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
Moderate
Sprague Dawley rat
intravenous administration
10 mg/kg
Single
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
Moderate
Sprague Dawley rat
intravenous administration
20 mg/kg
Single
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894
Title/Abstract Full Text View citing articles Show Details
% increase
Moderate
Sprague Dawley rat
intravenous administration
30 mg/kg
Single
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
Active
Sprague Dawley rat
intravenous administration
1.0 mg/kg
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
Low
Sprague Dawley rat
intravenous administration
10 mg/kg
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
107
%
Sprague Dawley rat
intravenous administration
3.2 mg/kg
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
Low
Sprague Dawley rat
intravenous administration
20 mg/kg
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
1
% increase
Not active
Sprague Dawley rat
intravenous administration
30 mg/kg
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
Low
Sprague Dawley rat
intravenous administration
5 mg/kg
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
Low
Sprague Dawley rat
intravenous administration
15 mg/kg
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
Identification
Physical Data Spectra Chemical Name: (R)-4-methylmethcathinone hydrochloride
1 prep out of 1 reactions.
Reaxys Registry Number: 28388620
Molecular Formula: C11H15NO*ClH Linear Structure Formula: C11H15NO*ClH Molecular Weight: 213.707
InChI Key: DLQZFTUKJGRPLZ-SBSPUUFOSA-N
Druglikeness
Bioactivity
Identification Physical Data (3) Spectra (3)
Show Targets
6
Synthesize | Hide Details Find similar Chemical Names and Synonyms (R)-4-methylmethcathinone hydrochloride, mephedrone hydrochloride Druglikeness Bioactivity In vitro: Efficacy (2) Quantitative Results pX
Parameter
7.27
EC50
Value (qual)
Value (quant)
Unit
Action on Target
54.31
nM
Stimulator
Target
Tissue/Organ
Sodiumdependent dopamine transporter:Wild
neostriatum
Cell
Bioassay
Dose
Effect
Reference (expand all/collapse all) British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
7.08
EC50
83.28
nM
Stimulator
Sodiumdependent serotonin transporter:Wild
brain
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
In vivo: Animal Model (17) Quantitative Results pX
Parameter
Value (qual)
% increase
Active
Value (quant)
Unit
Action on Target
Animal Model
Biological Species
Route of administration
Dose
Sprague Dawley rat
intravenous administration
15 mg/kg
Dosing regimen Repeated
Effect
Reference (expand all/collapse all) British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
High
Sprague Dawley rat
intravenous administration
30 mg/kg
Single
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
1
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
High
Sprague Dawley rat
intravenous administration
5 mg/kg
Single
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
High
Sprague Dawley rat
intravenous administration
10 mg/kg
Single
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
High
Sprague Dawley rat
intravenous administration
20 mg/kg
Single
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
1
% increase
Not active
Sprague Dawley rat
intravenous administration
15 mg/kg
Repeated
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
High
Sprague Dawley rat
intravenous administration
30 mg/kg
Single
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
High
Sprague Dawley rat
intravenous administration
5 mg/kg
Single
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
High
Sprague Dawley rat
intravenous administration
10 mg/kg
Single
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
High
Sprague Dawley rat
intravenous administration
20 mg/kg
Single
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894
Title/Abstract Full Text View citing articles Show Details
% increase
Diffuse
Sprague Dawley rat
intravenous administration
10 mg/kg
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
Moderate
Sprague Dawley rat
intravenous administration
1.0 mg/kg
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
143
%
Sprague Dawley rat
intravenous administration
3.2 mg/kg
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
High
Sprague Dawley rat
intravenous administration
20 mg/kg
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
High
Sprague Dawley rat
intravenous administration
30 mg/kg
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
Moderate
Sprague Dawley rat
intravenous administration
5 mg/kg
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
% increase
Low
Sprague Dawley rat
intravenous administration
15 mg/kg
British Journal of Pharm...
Title/Abstract Full Text View citing articles Show Details
Gregg, Ryan A.; Baumann, Michael H.; Partilla, John S.; Bonano, Julie S.; Vouga, Alexandre; Tallarida, Christopher S.; Velvadapu, Venkata; Smith, Garry R.; Peet, M. Melissa; Reitz, Allen B.; Negus, S. Stevens; Rawls, Scott M.
British Journal of Pharmacology, 2015 , vol. 172, # 3 p. 883 - 894 Title/Abstract Full Text View citing articles Show Details
Identification Physical Data Spectra Chemical Name: 2-methylamino-1-p-tolyl-propan-1-one; picrate Reaxys Registry Number: 3852052
Type of Substance: isocyclic
no reactions.
Druglikeness
Identification Physical Data (1)
Show Targets
1
Molecular Formula: C6H3N3O7*C11H15NO Linear Structure Formula: C11H15NO*C6H3N3O7
Molecular Weight: 406.352
InChI Key: JFGNLQAXEVAQIX-UHFFFAOYSA-N 7
Synthesize | Show Details Find similar
8
mixture (composition partially given) :
2-methylamino-1-(4-methylphenyl)propan-1-one desipramine
Reaxys Registry Number: 28309886 Type of Substance: mixture (composition partially given)
no reactions.
Show Targets
1
Show Targets
1
Hide Details
Composition 2-methylamino-1-(4-methylphenyl)propan-1-one
desipramine
9
mixture (composition partially given) :
2-methylamino-1-(4-methylphenyl)propan-1-one 1-(2-(di(4-fluorophenyl)-methoxy)-ethyl)-4-(3phenylpropyl)piperazine
Synthesize
Synthesize
Find similar
Find similar
Reaxys Registry Number: 28309887 Type of Substance: mixture (composition partially given)
no reactions.
Hide Details
Composition 1-(2-(di(4-fluorophenyl)-methoxy)-ethyl)-4-(3phenylpropyl)piperazine
2-methylamino-1-(4-methylphenyl)propan-1-one
Synthesize
Synthesize
Find similar
Find similar
10
mixture (composition partially given) :
2-methylamino-1-(4-methylphenyl)propan-1-one FLUOXETINE
Reaxys Registry Number: 28309888 Type of Substance: mixture (composition partially given)
no reactions.
Show Targets
1
Show Targets
1
Hide Details
Composition 2-methylamino-1-(4-methylphenyl)propan-1-one
11
mixture (composition partially given) :
1-(4-methylphenyl)-N-methyl-1-oxopropan-2-aminium chloridum monensin
FLUOXETINE
Synthesize
Synthesize
Find similar
Find similar
Reaxys Registry Number: 30112962 Type of Substance: mixture (composition partially given)
no reactions.
Hide Details
Composition monensin
1-(4-methylphenyl)-N-methyl-1-oxopropan-2-aminium chloridum
12
mixture (composition partially given) :
ecopipam 1-(4-methylphenyl)-N-methyl-1-oxopropan-2-aminium chloridum
Synthesize
Synthesize
Find similar
Find similar
Reaxys Registry Number: 31820925 Type of Substance: mixture (composition partially given)
no reactions.
Hide Details
Composition 1-(4-methylphenyl)-N-methyl-1-oxopropan-2-aminium chloridum
ecopipam
Synthesize
Synthesize
Find similar
Find similar
Show Targets
1