Query Query
Results
Date
2 reactions in Reaxys
2018-04-14 19h:01m:00s (UTC)
O N
O N
1. Query
N F O
Search as: As drawn
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
1/2
2018-04-14 19:27:54
O
O
N
N
O O
N
F
N F
O
O
N Cl
O
Rx-ID: 4111011 View in Reaxys 1/2 Yield
Conditions & References
92 %
With hexamethylenetetramine, urotropin hydrochloride in ethanol, Heating Clarke, George M.; Lee, J. Barry; Swinbourne, Frederick J.; Williamson, Basil; Journal of Chemical Research, Miniprint; nb. 12; (1980); p. 4777 - 4793 View in Reaxys
O N O
N
N F
O
Rx-ID: 6013991 View in Reaxys 2/2 Yield
Conditions & References Sternbach,L.H. et al.; Journal of Medicinal Chemistry; vol. 6; (1963); p. 261 - 265 View in Reaxys Patent; Hoffmann-La Roche Inc.; US3203990; (1962); ; vol. 64; nb. 3576f; (1966) View in Reaxys Patent; Hoffmann-La Roche; US3123529; (1962); ; vol. 60; nb. 12035; (1964) View in Reaxys Patent; Sumitomo; DE2017060; (1970); ; vol. 74; nb. 22904; (1971) View in Reaxys Patent; Hoffmann-LaRoche; AT334376; (1977); DE2233482; ; vol. 78; nb. 111385 View in Reaxys Patent; Hoffmann-La Roche; CH568303; (1975); DE2334273; ; vol. 80; nb. 108590 View in Reaxys Patent; Hoffmann-La Roche; GB1039372; (1963); ; vol. 65; nb. 15408g; (1966) View in Reaxys According to the process of the present invention, there are prepared, for example, the following benzodiazepine derivatives: 1-Methyl-5-(o-fluorophenyl)-1,3-dihydro-2H- 1,4-benzodiazepin-2-one. 1-Cyclopropylmethyl-5-(o-fluorophenyl)-7-chloro- 1,3-dihydro-2H-1,4-benzodiazepin-2-one 1-Methyl-5-phenyl-7-trifluoromethyl-1,3-dihydro- 2H-1,4-benzodiazepin-2-one 1-Methyl-5-(o-fluorophenyl)-7-nitro-1,3-dihydro- 2H-1,4-benzodiazepin-2-one 1-(β-Vinyloxyethyl)-5-phenyl-7-chloro-1,3-dihydro- 2H-1,4-benzodiazepin-2-one 1-(β-Methoxy-β -ethoxyethyl)-5-phenyl-7-chloro- 1,3-dihydro-2H-1,4-benzodiazepin-2-one 1-(β-Acetoxyethyl)-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one 1-(β-Methylthioethyl)-5-phenyl-7-chloro-1,3-dihydro- 2H-1,4-benzodiazepin-2-one 1-(β-Methylsulfinylethyl)-5-phenyl-7-chloro- 1,3-dihydro-2H-1,4-benzodiazepin-2-one ... Patent; Sumitomo Chemical Company, Limited; US3991048; (1976); (A) English View in Reaxys
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
2/2
2018-04-14 19:27:54