5-(2-Fluorophenyl)-1-methyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one (Flunitrazepam)

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12 substances in Reaxys

2018-04-14 18h:18m:53s (UTC)

O N

O N

1. Query

N F O

Search as: As drawn

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Reaxys ID 26138911 View in Reaxys

1/12

H 11 3 C

CAS Registry Number: 74143-28-5 Linear Structure Formula: C15 (11)CH12FN3O3 Molecular Formula: C16H12FN3O3 Molecular Weight: 312.277 InChI Key: PPTYJKAXVCCBDU-BJUDXGSMSA-N Note:

O

N O

N

N F

O

Druglikeness (1) 1 of 1

LogP

2.349

H Bond Donors

0

H Bond Acceptors

3

Rotatable Bonds

2

TPSA

78.49

Lipinski Number

4

Veber Number

2

Target Name

Gamma-aminobutyric acid receptor subunit delta;+Gamma-aminobutyric acid receptor subunit beta-2;+Gamma-aminobutyric acid receptor subunit alpha-1

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1; Gamma-aminobutyric acid receptor subunit beta-2; Gamma-aminobutyric acid receptor subunit delta

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta:Wild + Gamma-aminobutyric acid receptor subunit beta-2:Wild + Gamma-aminobutyric acid receptor subunit alpha-1:Wild

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Dissociation constant of the compound (11C labeled) towards gamma-aminobutyric acid A-Benzodiazepine receptor measured at 0 degree C

Substance RN

26138911View in Reaxys

Measurement Parameter

Kd

Unit

nM

Qualitative value

=

Quantitative value

1

Measurement pX

9

Medchem (1) 1 of 1

Reaxys ID 702691 View in Reaxys

2/12 CAS Registry Number: 1622-62-4 Chemical Name: flunitrazepam; 1-methyl-5-(2'-fluoro-phenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one; Flunitrazepam; 5-(2fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2one; (+/-)-flunitrazepam; [3H]-flunitrazepam; 3H-flunitrazepam Linear Structure Formula: C16H12FN3O3 Molecular Formula: C16H12FN3O3 Molecular Weight: 313.288 Type of Substance: heterocyclic InChI Key: PPTYJKAXVCCBDU-UHFFFAOYSA-N Note:

O N O

N

N F

O

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Substance Label (19) Label References 235

Oda, Shingo; Fujiwara, Ryoichi; Kutsuno, Yuki; Fukami, Tatsuki; Itoh, Tomoo; Yokoi, Tsuyoshi; Nakajima, Miki; Drug Metabolism and Disposition; vol. 43; nb. 6; (2015); p. 812 - 818, View in Reaxys

G55

Sobaska, Anna W.; Zydek, Grazyna; Wlodno, Piotr; Brzeziska, Elzbieta; European Journal of Medicinal Chemistry; vol. 89; (2014); p. 147 - 155, View in Reaxys

FMN

Megarbane, Bruno; Pirnay, Stephane; Borron, Stephen W.; Trout, Herve; Monier, Claire; Risede, Patricia; Boschi, Gabrielle; Baud, Frederic J.; Toxicology Letters; vol. 157; nb. 3; (2005); p. 211 - 219, View in Reaxys

1

Ogris, Waltraud; Poeltl, Angelika; Hauer, Birgit; Ernst, Margot; Oberto, Alessandra; Wulff, Peer; Hoeger, Harald; Wisden, William; Sieghart, Werner; Biochemical Pharmacology; vol. 68; nb. 8; (2004); p. 1621 - 1629, View in Reaxys

Merck 4181

Giorgi; Lecca; Cancedda; Serra; Corda; European Journal of Pharmacology - Molecular Pharmacology Section; vol. 290; nb. 1; (1995); p. 37 - 47, View in Reaxys; Klein; Mascia; Harkness; Hadingham; Whiting; Harris; Journal of Pharmacology and Experimental Therapeutics; vol. 274; nb. 3; (1995); p. 1484 - 1492, View in Reaxys; Duncalfe; Dunn; European Journal of Pharmacology; vol. 298; nb. 3; (1996); p. 313 - 319, View in Reaxys; Zezula, Juergen; Slany, Astrid; Sieghart, Werner; European Journal of Pharmacology; vol. 301; nb. 1-3; (1996); p. 207 - 214, View in Reaxys; Banerjee, Pradeep K.; Olsen, Richard W.; Snead III, O. Carter; Journal of Pharmacology and Experimental Therapeutics; vol. 291; nb. 1; (1999); p. 361 - 366, View in Reaxys; Huh, Kyung-Hye; Endo, Shuichi; Olsen, Richard W.; European Journal of Pharmacology; vol. 310; nb. 2-3; (1996); p. 225 - 233, View in Reaxys; Zhang, Zhang-Jin; Trivedi, Bakula L.; De Paulis, Tomas; Schmidt, Dennis E.; Hewlett, William A.; Naunyn-Schmiedeberg's Archives of Pharmacology; vol. 365; nb. 2; (2002); p. 123 - 132, View in Reaxys

FTZ

Moaddel; Cloix; Ertem; Wainer; Pharmaceutical Research; vol. 19; nb. 1; (2002); p. 104 - 107, View in Reaxys

FNM

Borron; Monier; Risede; Baud; Human and Experimental Toxicology; vol. 21; nb. 11; (2002); p. 599 - 605, View in Reaxys

Tab. IV

Moore; Pierfitte; Pehourcq; Lagnaoui; Begaud; Clinical Pharmacology and Therapeutics; vol. 69; nb. 6; (2001); p. 445 - 450, View in Reaxys

2

Sigel, Erwin; Schaerer, Martin T.; Buhr, Andreas; Baur, Roland; Molecular Pharmacology; vol. 54; nb. 6; (1998); p. 1097 - 1105, View in Reaxys

Merck 4172

Johnston, Jonathan D.; Price, Sally A.; Bristow, David R.; British Journal of Pharmacology; vol. 124; nb. 7; (1998); p. 1338 - 1340, View in Reaxys

FNZ

Bennett; Simmonds; British Journal of Pharmacology; vol. 117; nb. 1; (1996); p. 87 - 92, View in Reaxys; Uchida, Sunao; Okudaira, Nobuyuki; Nishihara, Kyoko; Iguchi, Yoshinobu; Tan, Xin; Life Sciences; vol. 59; nb. 9; (1996); p. PL117-PL120, View in Reaxys

M 4181

Slany; Zezula; Fuchs; Sieghart; European Journal of Pharmacology - Molecular Pharmacology Section; vol. 291; nb. 2; (1995); p. 99 - 105, View in Reaxys; Hosie, Alastair M.; Sattelle, David B.; British Journal of Pharmacology; vol. 117; nb. 6; (1996); p. 1229 - 1237, View in Reaxys

flunitrazepam

Suzuki, Toshihito; Ito, Takehiko; Wellman, Susan E.; Ho, Ing Kang; European Journal of Pharmacology; vol. 295; nb. 2-3; (1996); p. 169 - 179, View in Reaxys

Fln

Masonis, A. E. Tory; McCarthy, Michael P.; Journal of Pharmacology and Experimental Therapeutics; vol. 279; nb. 1; (1996); p. 186 - 193, View in Reaxys

Fig. 1, comp. B1

Maguire; Davies; Loew; European Journal of Pharmacology; vol. 280; nb. 2; (1995); p. 167 - 173, View in Reaxys

FLU

Feigenspan, Andreas; Bormann, Joachim; European Journal of Pharmacology, Molecular Pharmacology Section; vol. 288; nb. 1; (1995); p. 97 - 104, View in Reaxys

FNZ, Negwer 4957

Suzuki, Toshihito; Ito, Takehiko; Wellman, Susan E.; Ho, Ing Kang; Life Sciences; vol. 57; nb. 5; (1995); p. P63 P70, View in Reaxys

Merck 12,4181

Hadingham; Wafford; Thompson; Palmer; Whiting; European Journal of Pharmacology - Molecular Pharmacology Section; vol. 291; nb. 3; (1995); p. 301 - 309, View in Reaxys

(3H)flunitrazepam

Yu; Ticku; Journal of Pharmacology and Experimental Therapeutics; vol. 275; nb. 3; (1995); p. 1442 - 1446, View in Reaxys

Patent-Specific Data (1) Prophetic ComReferences pound prophetic product

Patent; Sumitomo Chemical Company, Limited; US3991048; (1976); (A) English, View in Reaxys; Patent; Schollmayer, Erwin; Sachse, Richard; Braun, Marina; US2008/274061; (2008); (A1) English, View in Reaxys

Druglikeness (1)

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1 of 1

LogP

2.349

H Bond Donors

0

H Bond Acceptors

3

Rotatable Bonds

2

TPSA

78.49

Lipinski Number

4

Veber Number

2

Highest Clinical Phase (1) Highest Clinical Phase Marketed Melting Point (3) 1 of 3

Melting Point [°C]

168 - 170

Patent; Hoffmann-LaRoche; AT334376; (1977); DE2233482; Chem.Abstr.; vol. 78; nb. 111385, View in Reaxys 2 of 3

Melting Point [°C]

170 - 171.5

de Silva et al.; Analytical Chemistry; vol. 48; (1976); p. 10,11, View in Reaxys 3 of 3

Melting Point [°C]

170 - 172

Solvent (Melting Point)

CH2Cl2; hexane

Sternbach,L.H. et al.; Journal of Medicinal Chemistry; vol. 6; (1963); p. 261 - 265, View in Reaxys Adsorption (MCS) (1) 1 of 1

Description (Adsorption (MCS))

Adsorption

Solvent (Adsorption (MCS))

aq. phosphate buffer

Temperature (Adsorption (MCS)) [°C]

20

Comment (Adsorption (MCS))

pH dependence

Partner (Adsorption (MCS))

poly(acrylic acid)-poly(vinylidene fluoride) membrane

Akerman, Satu; Akerman, Kari; Karppi, Jouni; Koivu, Paeivi; Sundell, Annika; Paronen, Petteri; Jaervinen, Kristiina; European Journal of Pharmaceutical Sciences; vol. 9; nb. 2; (1999); p. 137 - 143, View in Reaxys Association (MCS) (2) 1 of 2

Description (Association (MCS))

Stability constant of the complex with ...

Solvent (Association (MCS))

various solvent(s)

Partner (Association (MCS))

immobilized phospholipid membrane

Hollosy, Ferenc; Valko, Klara; Hersey, Anne; Nunhuck, Shenaz; Keri, Gyoergy; Bevan, Chris; Journal of Medicinal Chemistry; vol. 49; nb. 24; (2006); p. 6958 - 6971, View in Reaxys 2 of 2

Description (Association (MCS))

Stability constant of the complex with ...

Solvent (Association (MCS))

various solvent(s)

Partner (Association (MCS))

human serum albumin

Hollosy, Ferenc; Valko, Klara; Hersey, Anne; Nunhuck, Shenaz; Keri, Gyoergy; Bevan, Chris; Journal of Medicinal Chemistry; vol. 49; nb. 24; (2006); p. 6958 - 6971, View in Reaxys Conformation (1)

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Object of Investiga- References tion Conformer equilibrium

Sarrazin et al.; Organic Magnetic Resonance; vol. 7; (1975); p. 89,92, View in Reaxys

Dissociation Exponent (1) 1 of 1

Comment (Dissociation Exponent)

(k')pK

Su; Carstensen; Journal of Pharmaceutical Sciences; vol. 61; (1972); p. 420,421, View in Reaxys Electrical Moment (1) 1 of 1

Description (Electrical Moment)

Dipole moment

Su; Carstensen; Journal of Pharmaceutical Sciences; vol. 61; (1972); p. 420,421, View in Reaxys Liquid/Liquid Systems (MCS) (4) 1 of 4

Description (Liquid/Liquid Distribution between solvent 1 + 2 Systems (MCS)) Temperature (Liquid/ Liquid Systems (MCS)) [°C]

37

Partner (Liquid/Liquid Systems (MCS))

human milk lipid-ultrafiltrate

Atkinson; Begg; Journal of Pharmaceutical Sciences; vol. 77; nb. 9; (1988); p. 796 - 798, View in Reaxys 2 of 4

Description (Liquid/Liquid Distribution between solvent 1 + 2 Systems (MCS)) Temperature (Liquid/ Liquid Systems (MCS)) [°C]

37

Partner (Liquid/Liquid Systems (MCS))

octanol; H2O

Atkinson; Begg; Journal of Pharmaceutical Sciences; vol. 77; nb. 9; (1988); p. 796 - 798, View in Reaxys 3 of 4

Description (Liquid/Liquid Distribution between solvent 1 + 2 Systems (MCS)) Partner (Liquid/Liquid Systems (MCS))

octanol/phosphate buffer (pH = 7.5)

Lacko; Wittke; Arzneimittel-Forschung/Drug Research; vol. 34; nb. 4; (1984); p. 403 - 407, View in Reaxys 4 of 4

Description (Liquid/Liquid Distribution between solvent 1 + 2 Systems (MCS)) Temperature (Liquid/ Liquid Systems (MCS)) [°C]

25

Partner (Liquid/Liquid Systems (MCS))

n-octanol, aq. phosphate buffer

Seiler; Zimmermann; Arzneimittel-Forschung/Drug Research; vol. 33; nb. 11; (1983); p. 1519 - 1522, View in Reaxys Partition octan-1-ol/water (MCS) (5) 1 of 5

log POW

2.56

Location

supporting information

Rankovic, Zoran; Journal of Medicinal Chemistry; vol. 60; nb. 14; (2017); p. 5943 - 5954, View in Reaxys 2 of 5

log POW

2.56

pH

7.4

Location

supporting information

Comment (Partition octan-1-ol/water (MCS))

aq.buffer

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Rankovic, Zoran; Journal of Medicinal Chemistry; vol. 60; nb. 14; (2017); p. 5943 - 5954, View in Reaxys 3 of 5

Partition Constant POW

134

Gatta, Elena; Cupello, Aroldo; Di Braccio, Mario; Grossi, Giancarlo; Robello, Mauro; Scicchitano, Francesca; Russo, Emilio; De Sarro, Giovambattista; Journal of Molecular Neuroscience; vol. 60; nb. 4; (2016); p. 539 - 547, View in Reaxys 4 of 5

log POW

-1.28

Location

supporting information

Sobaska, Anna W.; Zydek, Grazyna; Wlodno, Piotr; Brzeziska, Elzbieta; European Journal of Medicinal Chemistry; vol. 89; (2014); p. 147 - 155, View in Reaxys 5 of 5

log POW

2.14

Hollosy, Ferenc; Valko, Klara; Hersey, Anne; Nunhuck, Shenaz; Keri, Gyoergy; Bevan, Chris; Journal of Medicinal Chemistry; vol. 49; nb. 24; (2006); p. 6958 - 6971, View in Reaxys Solubility (MCS) (1) 1 of 1

Solubility [g·l-1]

0.0169176

Saturation

in solution

Temperature (Solubility (MCS)) [°C]

25

Solvent (Solubility (MCS))

phosphate buffer

Alelyunas, Yun W.; Empfield, James R.; McCarthy, Dennis; Spreen, Russell C.; Bui, Khanh; Pelosi-Kilby, Luciana; Shen, Cindy; Bioorganic and Medicinal Chemistry Letters; vol. 20; nb. 24; (2010); p. 7312 - 7316, View in Reaxys Solution Behaviour (MCS) (1) 1 of 1

Description (Solution Behaviour (MCS))

Solubilizing

Solvent (Solution Behaviour (MCS))

H2O

Temperature (Solution Be- 37 haviour (MCS)) [°C] Comment (Solution Behaviour (MCS))

concentration dependence. Object(s) of Study: time dependence. Object(s) of Study: diagram

Partner (Solution Behaviour (MCS))

oxazepam

Liu, Julie; Journal of Pharmaceutical Sciences; vol. 87; nb. 12; (1998); p. 1632 - 1638, View in Reaxys NMR Spectroscopy (12) 1 of 12

Description (NMR Spectroscopy)

Spectrum

Nucleus (NMR Spectroscopy)

1H

Solvents (NMR Spectroscopy)

CD2Cl2; various solvent(s)

Temperature (NMR Spectroscopy) [°C]

-20

Finner; Zeugner; Milkowski; Archiv der Pharmazie; vol. 317; nb. 12; (1984); p. 1050 - 1053, View in Reaxys 2 of 12

Description (NMR Spectroscopy)

Chemical shifts

Nucleus (NMR Spectroscopy)

13C

Solvents (NMR Spectroscopy)

dimethylsulfoxide-d6

Haran; Tuchagues; Journal of Heterocyclic Chemistry; vol. 17; nb. 7; (1980); p. 1483 - 1488, View in Reaxys; Finner; Zeugner; Milkowski; Archiv der Pharmazie; vol. 317; nb. 12; (1984); p. 1050 - 1053, View in Reaxys

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3 of 12

Description (NMR Spectroscopy)

Chemical shifts

Nucleus (NMR Spectroscopy)

13C

Solvents (NMR Spectroscopy)

CDCl3

Finner; Zeugner; Milkowski; Archiv der Pharmazie; vol. 317; nb. 12; (1984); p. 1050 - 1053, View in Reaxys 4 of 12

Description (NMR Spectroscopy)

Spin-spin coupling constants

Solvents (NMR Spectroscopy)

CD2Cl2

Temperature (NMR Spectroscopy) [°C]

-20

Comment (NMR Spectroscopy)

19F-1H. Solvent(s): further solvent(s)

Finner; Zeugner; Milkowski; Archiv der Pharmazie; vol. 317; nb. 12; (1984); p. 1050 - 1053, View in Reaxys 5 of 12

Description (NMR Spectroscopy)

Spin-spin coupling constants

Solvents (NMR Spectroscopy)

CDCl3

Comment (NMR Spectroscopy)

19F-13C.

Finner; Zeugner; Milkowski; Archiv der Pharmazie; vol. 317; nb. 12; (1984); p. 1050 - 1053, View in Reaxys 6 of 12

Description (NMR Spectroscopy)

Spin-spin coupling constants

Solvents (NMR Spectroscopy)

dimethylsulfoxide-d6

Comment (NMR Spectroscopy)

19F-13C.

Finner; Zeugner; Milkowski; Archiv der Pharmazie; vol. 317; nb. 12; (1984); p. 1050 - 1053, View in Reaxys 7 of 12

Description (NMR Spectroscopy)

Chemical shifts

Nucleus (NMR Spectroscopy)

1H

Solvents (NMR Spectroscopy)

dimethylsulfoxide-d6

Haran; Tuchagues; Journal of Heterocyclic Chemistry; vol. 17; nb. 7; (1980); p. 1483 - 1488, View in Reaxys 8 of 12

Description (NMR Spectroscopy)

Chemical shifts

Nucleus (NMR Spectroscopy)

13C

Solvents (NMR Spectroscopy)

dimethylsulfoxide-d6

Temperature (NMR Spectroscopy) [°C]

28

Sarrazin, Marcel; Faure, Robert; Aubert, Claude; Vincent, Emile-Jean; Journal de Chimie Physique et de Physico-Chimie Biologique; vol. 77; nb. 1; (1980); p. 91 - 94, View in Reaxys 9 of 12

Description (NMR Spectroscopy)

Spin-spin coupling constants

Solvents (NMR Spectroscopy)

CDCl3

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Comment (NMR Spectroscopy)

1H-1H, 19F-1H.

Haran; Tuchagues; Journal of Heterocyclic Chemistry; vol. 17; nb. 7; (1980); p. 1483 - 1488, View in Reaxys 10 of 12

Description (NMR Spectroscopy)

Spin-spin coupling constants

Solvents (NMR Spectroscopy)

CDCl3

Comment (NMR Spectroscopy)

1H-13C, 19F-13C.

Haran; Tuchagues; Journal of Heterocyclic Chemistry; vol. 17; nb. 7; (1980); p. 1483 - 1488, View in Reaxys 11 of 12

Description (NMR Spectroscopy)

Spin-spin coupling constants

Solvents (NMR Spectroscopy)

dimethylsulfoxide-d6

Temperature (NMR Spectroscopy) [°C]

28

Comment (NMR Spectroscopy)

19F-13C.

Sarrazin, Marcel; Faure, Robert; Aubert, Claude; Vincent, Emile-Jean; Journal de Chimie Physique et de Physico-Chimie Biologique; vol. 77; nb. 1; (1980); p. 91 - 94, View in Reaxys 12 of 12

Description (NMR Spectroscopy)

NMR

Ficarra et al.; Bollettino Chimico Farmaceutico; vol. 116; (1977); p. 720,721, 724, 727-729, View in Reaxys; Sarrazin et al.; Organic Magnetic Resonance; vol. 7; (1975); p. 89,92, View in Reaxys IR Spectroscopy (2) 1 of 2

Description (IR Spectroscopy)

Spectrum

Solvent (IR Spectroscopy)

KBr

Comment (IR Spectroscopy)

4000 - 800 cm**(-1)

Huvenne, J. P.; Lacroix, B.; Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy; vol. 44; nb. 1; (1988); p. 109 - 114, View in Reaxys 2 of 2

Description (IR Spectroscopy)

IR

Ficarra et al.; Bollettino Chimico Farmaceutico; vol. 116; (1977); p. 720,721, 724, 727-729, View in Reaxys Mass Spectrometry (5) Description (Mass References Spectrometry) electrospray ionisa- Treu, Axel; Rittner, Miriam; Kemken, Dorit; Schiebel, Hans-Martin; Spiteller, Peter; Dülcks, Thomas; Journal of tion (ESI); liquid Mass Spectrometry; vol. 50; nb. 8; (2015); p. 978 - 986, View in Reaxys chromatography mass spectrometry (LCMS); IT (ion trap); tandem mass spectrometry; spectrum electron impact (EI); fragmentation pattern; spectrum

Leesakul, Nararak; Pongampai, Sirintip; Kanatharana, Proespichaya; Sudkeaw, Pravit; Tantirungrotechai, Yuthana; Buranachai, Chittanon; Luminescence; vol. 28; nb. 1; (2013); p. 76 - 83, View in Reaxys

DESI (desorption Liu, Pengyuan; Lanekoff, Ingela T.; Laskin, Julia; Dewald, Howard D.; Chen, Hao; Analytical Chemistry; vol. 84; electrospray ioniza- nb. 13; (2012); p. 5737 - 5743, View in Reaxys tion); Spectrum LCMS (Liquid chromatography mass spectrome-

Remane, Daniela; Wissenbach, Dirk K.; Meyer, Markus R.; Maurer, Hans H.; Rapid Communications in Mass Spectrometry; vol. 24; nb. 7; (2010); p. 859 - 867, View in Reaxys

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try); Tandem mass spectrometry; Spectrum spectrum; chemical ionization (CI)

Kratzsch, Carsten; Tenberken, Oliver; Peters, Frank T.; Weber, Armin A.; Kraemer, Thomas; Maurer, Hans H.; Journal of Mass Spectrometry; vol. 39; nb. 8; (2004); p. 856 - 872, View in Reaxys

UV/VIS Spectroscopy (10) 1 of 10

Description (UV/VIS Spectroscopy)

Spectrum

Solvent (UV/VIS Spectroscopy)

nitric acid

Absorption Maxima (UV/ VIS) [nm]

247; 305

Leesakul, Nararak; Pongampai, Sirintip; Kanatharana, Proespichaya; Sudkeaw, Pravit; Tantirungrotechai, Yuthana; Buranachai, Chittanon; Luminescence; vol. 28; nb. 1; (2013); p. 76 - 83, View in Reaxys 2 of 10

Description (UV/VIS Spectroscopy)

Spectrum

Solvent (UV/VIS Spectroscopy)

ethanol

Absorption Maxima (UV/ VIS) [nm]

253; 304

Leesakul, Nararak; Pongampai, Sirintip; Kanatharana, Proespichaya; Sudkeaw, Pravit; Tantirungrotechai, Yuthana; Buranachai, Chittanon; Luminescence; vol. 28; nb. 1; (2013); p. 76 - 83, View in Reaxys 3 of 10

Description (UV/VIS Spectroscopy)

Spectrum

Solvent (UV/VIS Spectroscopy)

ethanol

Absorption Maxima (UV/ VIS) [nm]

253; 309

Leesakul, Nararak; Pongampai, Sirintip; Kanatharana, Proespichaya; Sudkeaw, Pravit; Tantirungrotechai, Yuthana; Buranachai, Chittanon; Luminescence; vol. 28; nb. 1; (2013); p. 76 - 83, View in Reaxys 4 of 10

Description (UV/VIS Spectroscopy)

Spectrum

Solvent (UV/VIS Spectroscopy)

hydrogenchloride

Absorption Maxima (UV/ VIS) [nm]

280; 360

Leesakul, Nararak; Pongampai, Sirintip; Kanatharana, Proespichaya; Sudkeaw, Pravit; Tantirungrotechai, Yuthana; Buranachai, Chittanon; Luminescence; vol. 28; nb. 1; (2013); p. 76 - 83, View in Reaxys 5 of 10

Description (UV/VIS Spectroscopy)

Spectrum

Solvent (UV/VIS Spectroscopy)

perchloric acid

Absorption Maxima (UV/ VIS) [nm]

280; 360

Leesakul, Nararak; Pongampai, Sirintip; Kanatharana, Proespichaya; Sudkeaw, Pravit; Tantirungrotechai, Yuthana; Buranachai, Chittanon; Luminescence; vol. 28; nb. 1; (2013); p. 76 - 83, View in Reaxys 6 of 10

Description (UV/VIS Spectroscopy)

Spectrum

Solvent (UV/VIS Spectroscopy)

sulfuric acid

Absorption Maxima (UV/ VIS) [nm]

280; 360

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Leesakul, Nararak; Pongampai, Sirintip; Kanatharana, Proespichaya; Sudkeaw, Pravit; Tantirungrotechai, Yuthana; Buranachai, Chittanon; Luminescence; vol. 28; nb. 1; (2013); p. 76 - 83, View in Reaxys 7 of 10

Description (UV/VIS Spectroscopy)

Spectrum

Solvent (UV/VIS Spectroscopy)

acetic acid

Leesakul, Nararak; Pongampai, Sirintip; Kanatharana, Proespichaya; Sudkeaw, Pravit; Tantirungrotechai, Yuthana; Buranachai, Chittanon; Luminescence; vol. 28; nb. 1; (2013); p. 76 - 83, View in Reaxys 8 of 10

Description (UV/VIS Spectroscopy)

Spectrum

Solvent (UV/VIS Spectroscopy)

various solvent(s)

Comment (UV/VIS Spectroscopy)

200 - 400 nm; Remark: T = 25 deg C

Moro; Novillo-Fertrell; Velazquez; Rodriguez; Journal of Pharmaceutical Sciences; vol. 80; nb. 5; (1991); p. 459 - 468, View in Reaxys 9 of 10

Description (UV/VIS Spectroscopy)

Spectrum

Solvent (UV/VIS Spectroscopy)

aq. HCl

Comment (UV/VIS Spectroscopy)

200 - 400 nm; Remark: T = 25 deg C

Moro; Novillo-Fertrell; Velazquez; Rodriguez; Journal of Pharmaceutical Sciences; vol. 80; nb. 5; (1991); p. 459 - 468, View in Reaxys 10 of 10

Description (UV/VIS Spectroscopy)

UV/VIS

Ficarra et al.; Bollettino Chimico Farmaceutico; vol. 116; (1977); p. 720,721, 724, 727-729, View in Reaxys; Levillain et al.; European Journal of Medicinal Chemistry; vol. 10; (1975); p. 433,436, View in Reaxys Fluorescence Spectroscopy (1) Description (Fluo- References rescence Spectroscopy) Spectrum; Maxima

Leesakul, Nararak; Pongampai, Sirintip; Kanatharana, Proespichaya; Sudkeaw, Pravit; Tantirungrotechai, Yuthana; Buranachai, Chittanon; Luminescence; vol. 28; nb. 1; (2013); p. 76 - 83, View in Reaxys

Ecotoxicology (1) 1 of 1

Effect (Ecotoxicology)

chloride channel modulator

Species or Test-System (Ecotoxicology)

Xenopus laevis oocytes

Concentration (Ecotoxicology)

0.1 - 100 μmol/l

Method (Ecotoxicology)

cells injected with cRNA of wild-type Drosophila melanogaster GABA-receptor RDL subunit; perfused with saline; membrane currents (I) induced by 10μM GABA; title comp. added to perfusate

Further Details (Ecotoxicology)

I recorded with two-electrode voltage-clamp (-60 mV; 20 deg C); title comp. effect on GABA-induced I studied

Comment (Ecotoxicology) No effect Hosie, Alastair M.; Sattelle, David B.; British Journal of Pharmacology; vol. 117; nb. 6; (1996); p. 1229 - 1237, View in Reaxys Use (23) Use Pattern Benzodiazepine of a pharmaceutical composition for treating alcoholism

Location

References Patent; THE UNIVERSITY OF CHICAGO; WO2008/45641; (2008); (A2) English, View in Reaxys

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Benzodiazepine of a pharmaceutical composition for treating substance addiction

Patent; THE UNIVERSITY OF CHICAGO; WO2008/45641; (2008); (A2) English, View in Reaxys

Benzodiazepine of a pharmaceutical composition for treating cocaine abuse

Patent; THE UNIVERSITY OF CHICAGO; WO2008/45641; (2008); (A2) English, View in Reaxys

Benzodiazepine of a pharmaceutical composition for treating symptom of alcohol withdrawal

Patent; THE UNIVERSITY OF CHICAGO; WO2008/45641; (2008); (A2) English, View in Reaxys

Benzodiazepine of a pharmaceutical composition to cause alcohol aversion

Patent; THE UNIVERSITY OF CHICAGO; WO2008/45641; (2008); (A2) English, View in Reaxys

Benzodiazepine of a pharmaceutical composition for treating drug addiction

Patent; THE UNIVERSITY OF CHICAGO; WO2008/45641; (2008); (A2) English, View in Reaxys

Benzodiazepine of a pharmaceutical composition for treating alcohol use disorders

Patent; THE UNIVERSITY OF CHICAGO; WO2008/45641; (2008); (A2) English, View in Reaxys

Benzodiazepine of a pharmaceutical composition to improve the patient's rehabilitation of chronic alcoholism

Patent; THE UNIVERSITY OF CHICAGO; WO2008/45641; (2008); (A2) English, View in Reaxys

Anxiolytics

Patent; ASTRAZENECA AB; WO2007/86799; (2007); (A1) English, View in Reaxys

muscle spasm

Patent; Lundeen, James E.; US2006/148841; (2006); (A1) English, View in Reaxys

skeletal muscle relaxant

Patent; Lundeen, James E.; US2006/148841; (2006); (A1) English, View in Reaxys

insomnia

Patent; JAGOTEC AG; WO2006/45618; (2006); (A1) English, View in Reaxys

AKR1C2 inhibitor; AKR1C3 inhibitor

Page/Page column 80; 111

Patent; Ghosal, Anima; Kishnani, Narendra S.; Alton, Kevin B.; White, Ronald E.; US2006/276404; (2006); (A1) English, View in Reaxys

Hepatitis C virus (HCV)

Page/Page column 80; 111

Patent; Ghosal, Anima; Kishnani, Narendra S.; Alton, Kevin B.; White, Ronald E.; US2006/276404; (2006); (A1) English, View in Reaxys

Disorder associated Page/Page column with HCV 80; 111

Patent; Ghosal, Anima; Kishnani, Narendra S.; Alton, Kevin B.; White, Ronald E.; US2006/276404; (2006); (A1) English, View in Reaxys

sleep disturbance

Patent; Vela Pharmaceuticals Inc.; EP1202722; (2005); (B1) English, View in Reaxys

pharmaceutical composition with improved safety

Patent; Lotus Pharmaceutical Co., Ltd.; US2005/220715; (2005); (A1) English, View in Reaxys

anxiolytic-hypnotic therapeutic agent

Patent; Lotus Pharmaceutical Co., Ltd.; US2005/220715; (2005); (A1) English, View in Reaxys

Suitable antipsychotic agent

Patent; Yamanouchi Pharma Technologies, Inc.; US2005/208133; (2005); (A1) English, View in Reaxys

hypnotic agent(fastacting benzodiaze-

Patent; SANTARUS, INC.; WO2005/44199; (2005); (A2) English, View in Reaxys

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pine) of pharmaceutical compositions comprising a proton pump inhibitor, a buffering agent, and a sleep aid for the subject is awakened by distress associated with the gastric acid related disorder sleep onset insomnia

Patent; SANTARUS, INC.; WO2005/44199; (2005); (A2) English, View in Reaxys

sleep maintenance insomnia

Patent; SANTARUS, INC.; WO2005/44199; (2005); (A2) English, View in Reaxys

sleep offset insomnia

Patent; SANTARUS, INC.; WO2005/44199; (2005); (A2) English, View in Reaxys

Quantum Chemical Calculations (2) Calculated Proper- Method (Quantum ties Chemical Calculations) Atom distances, an- further quantum gles; Dipole mochemical calcns. ment, dipole moment derivative; Polarizability, polarizability derivatives; Electronic energy levels UV/VIS wave lengths

Location

References

supporting informa- Sobaska, Anna W.; Zydek, Grazyna; Wlodno, Piotr; Brzeziska, Elzbietion ta; European Journal of Medicinal Chemistry; vol. 89; (2014); p. 147 - 155, View in Reaxys

Ab initio calcns. (LCAO, GO SCF, DIM, SAMO, X-à, Hartree-Fock)

Leesakul, Nararak; Pongampai, Sirintip; Kanatharana, Proespichaya; Sudkeaw, Pravit; Tantirungrotechai, Yuthana; Buranachai, Chittanon; Luminescence; vol. 28; nb. 1; (2013); p. 76 - 83, View in Reaxys

Medchem (976) 1 of 976

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

forebrain

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flu

Measurement Parameter

Kd

Unit

nM

Quantitative value

5.8

Measurement pX

8.24

Concomitants: Compound RN

754371

Concomitants: Compound name

Diazepam

Concomitants: Compound role

NSB

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2 of 976

3 of 976

4 of 976

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

forebrain

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flu

Measurement Parameter

Bmax

Unit

pmol/g tissue

Quantitative value

103

Concomitants: Compound RN

754371

Concomitants: Compound name

Diazepam

Concomitants: Compound role

NSB

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

forebrain

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flu

Measurement Parameter

Kd

Unit

nM

Quantitative value

2.3

Measurement pX

8.64

Concomitants: Compound RN

754371; 906818

Concomitants: Compound name

Diazepam; GABA

Concomitants: Compound role

NSB; COM

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

forebrain

Cell Fraction

Membrane

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5 of 976

6 of 976

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flu

Measurement Parameter

Bmax

Unit

pmol/g tissue

Quantitative value

104

Concomitants: Compound RN

754371; 906818

Concomitants: Compound name

Diazepam; GABA

Concomitants: Compound role

NSB; COM

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

forebrain

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flu

Measurement Parameter

IC50

Unit

µM

Quantitative value

5

Measurement pX

5.3

Concomitants: Compound RN

8141905; 702691

Concomitants: Compound name

[35S]-TBPS; [3H]-Flunitrazepam

Concomitants: Compound role

RAD; RAD

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

forebrain

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flu

Measurement Parameter

IC50

Unit

µM

Quantitative value

2.5

Measurement pX

5.6

Concomitants: Compound RN

702691; 906818

Concomitants: Compound name

[3H]-Flunitrazepam; GABA

Concomitants: Compound role

RAD; COM

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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7 of 976

8 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

100 nM

Measurement Parameter

% Inhibition

Unit

%

Measurement Object

ALL

Quantitative value

18

Measurement pX

1

Concomitants: Compound RN

24140787; 6182863; 3885115

Concomitants: Compound name

Glucose-6-phosphate; Buprenorphine; NADP

Concomitants: Compound role

COM; SUB; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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9 of 976

Bioassay Name

Enzymology inhibition

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

100 nM

Measurement Parameter

% Inhibition

Unit

%

Measurement Object

ALL

Quantitative value

14

Measurement pX

1

Concomitants: Compound RN

19279336; 24140787; 6182863; 3885115

Concomitants: Compound name

NADPH regenerating System; Glucose-6-phosphate; Buprenorphine; NADP

Concomitants: Compound role

VPR; COM; SUB; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

100 nM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

14

Measurement pX

1

Metabolite RN

9596605

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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10 of 976

11 of 976

Metabolite name

Norbuprenorphine

Concomitants: Compound RN

24140787; 6182863; 3885115

Concomitants: Compound name

Glucose-6-phosphate; Buprenorphine; NADP

Concomitants: Compound role

COM; SUB; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

100 nM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

9

Measurement pX

1

Metabolite RN

9596605

Metabolite name

Norbuprenorphine

Concomitants: Compound RN

19279336; 24140787; 6182863; 3885115

Concomitants: Compound name

NADPH regenerating System; Glucose-6-phosphate; Buprenorphine; NADP

Concomitants: Compound role

VPR; COM; SUB; COE

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p28472 + p18507 + p14867

Target PDB ID

4cof

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12 of 976

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p28472 + p18507 + p14867

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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13 of 976

14 of 976

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p28472 + p18507 + p14867

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p28472 + p18507 + p14867

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

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15 of 976

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p28472 + p18507 + p14867

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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17 of 976

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p28472 + p18507 + p14867

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-2 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-2; gabra2; gamma-aminobutyric acid receptor subunit alpha-2

Target Uniprot ID

p28472 + p18507 + p47869

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-2 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-2 [human]:Wild

Target Species (Bioactivity)

human

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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18 of 976

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-2 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-2; gabra2; gamma-aminobutyric acid receptor subunit alpha-2

Target Uniprot ID

p28472 + p18507 + p47869

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-2 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-2 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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20 of 976

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-2 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-2; gabra2; gamma-aminobutyric acid receptor subunit alpha-2

Target Uniprot ID

p28472 + p18507 + p47869

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-2 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-2 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-3 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p28472 + p18507 + p34903

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-3 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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22 of 976

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-3 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p28472 + p18507 + p34903

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-3 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-3 [human]

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p28472 + p18507 + p34903

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-3 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-3 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p28472 + p18507 + p34903

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-3 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

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24 of 976

25 of 976

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-3 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p28472 + p18507 + p34903

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-3 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-3 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p28472 + p18507 + p34903

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Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-3 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Thyrotropin-releasing hormone receptor [human]

Target Synonyms

thyroliberin receptor; thyrotropin-releasing hormone receptor; trh-r; trhr

Target Uniprot ID

p34981

Target, Subunit, Species

Thyrotropin-releasing hormone receptor [human]

Target Mutant/Chimera Details

Thyrotropin-releasing hormone receptor [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

CHO-DXB11 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

-0.5

Measurement pX

1

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Concomitants: Compound RN

24142632; 24142632

Concomitants: Compound name

Thyrotropin releasing hormone; [3H]-TRH; BSA

Concomitants: Compound role

NSB; RAD; COM

Target Name

Thyrotropin-releasing hormone receptor [human]

Target Synonyms

thyroliberin receptor; thyrotropin-releasing hormone receptor; trh-r; trhr

Target Uniprot ID

p34981

Target, Subunit, Species

Thyrotropin-releasing hormone receptor [human]

Target Mutant/Chimera Details

Thyrotropin-releasing hormone receptor [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

CHO-DXB11 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

-13.7

Measurement pX

1

Concomitants: Compound RN

24142632; 24142632

Concomitants: Compound name

Thyrotropin releasing hormone; [3H]-TRH; BSA

Concomitants: Compound role

NSB; RAD; COM

Target Name

Thyrotropin-releasing hormone receptor [human]

Target Synonyms

thyroliberin receptor; thyrotropin-releasing hormone receptor; trh-r; trhr

Target Uniprot ID

p34981

Target, Subunit, Species

Thyrotropin-releasing hormone receptor [human]

Target Mutant/Chimera Details

Thyrotropin-releasing hormone receptor [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

CHO-DXB11 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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30 of 976

Substance Name

Flunitrazepam

Substance Dose

100 µM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

-4

Measurement pX

1

Concomitants: Compound RN

24142632; 24142632

Concomitants: Compound name

Thyrotropin releasing hormone; [3H]-TRH; BSA

Concomitants: Compound role

NSB; RAD; COM

Target Name

GABA-A receptor [taurine cattle]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [taurine cattle]

Target Mutant/Chimera Details

GABA-A receptor [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

taurine cattle

Organs/Tissues

brain cortex

Cell Fraction

Membrane: homogenate

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Ki

Unit

nM

Quantitative value

5.17

Deviation

0.200000

Measurement pX

8.29

Concomitants: Compound RN

4763661

Concomitants: Compound name

[3H]-Ro 15-1788

Concomitants: Compound role

RAD

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Bioassay : in vitro; saturation and competitive binding assays performed with <3H>Ro15-1788 or alpidem, 0 deg C; incubation time 90 min; liquid scintillation method

Biological Species/NCBI ID

Rattus norvegicus

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Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1.00000E-11 M

Measurement Parameter

Ki

Unit

nM

Quantitative value

0.28 - 65.6

Measurement pX

9.55

Maguire; Mechanick; Davies; Ellis; Meredith; Loew; Journal of Pharmacology and Experimental Therapeutics; vol. 273; nb. 2; (1995); p. 842 - 849, View in Reaxys 31 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : chloride channel modulatorBioassay : I recorded with two-electrode voltage-clamp (-60 mV; 20 deg C); title comp. effect on GABA-induced I studied cells injected with cRNA of wildtype Drosophila melanogaster GABA-receptor RDL subunit; perfused with saline; membrane currents (I) induced by 10μM GABA; title comp. added to perfusate

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.100000 µM

Measurement Parameter

Qualitative

Qualitative value

NA

Measurement pX

1

Hosie, Alastair M.; Sattelle, David B.; British Journal of Pharmacology; vol. 117; nb. 6; (1996); p. 1229 - 1237, View in Reaxys 32 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : ion transportTarget : brain from Sprague-Dawley ratBioassay : (36)Cl(-) uptake determined by radioactivity measurement; title comp. effect on M-induced (36)Cl(-) uptake in Co, Ce for NO and SE rats studied adult male rats (12 h light/dark cycle; normal <NO> or in pilocarpin-induced status epilepticus <SE>) sacrificed; cortical (Co) and cerebellar (Ce) synaptoneurosomes prep.; incub. with title comp.+(36)Cl(-)+muscimol (M) in assay buffer (34 deg C; 5 min)

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1 µM

Qualitative Results

ca. 10 percent increase of stimulated (36)Cl(-) influx; similar for Co, Ce in NO, SE

Measurement Parameter

Qualitative

Banerjee, Pradeep K.; Olsen, Richard W.; Snead III, O. Carter; Journal of Pharmacology and Experimental Therapeutics; vol. 291; nb. 1; (1999); p. 361 - 366, View in Reaxys 33 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

central nervous system depressant, action verified by recording the bioelectrical activity of the precentral cortex (in rabbits)

Measurement Parameter

Qualitative

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Stumpf Ch.; Viernstein; Journal of Pharmaceutical Sciences; vol. 79; nb. 12; (1990); p. 1062 - 1064, View in Reaxys 34 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : Sprague-Dawley rat cortical synaptoneurosomesBioassay : radioactivity quantitation using liquid scintillation spectrometry rats (4-5 wk); purified cerebrocortical membranes were incubated with 5 nmol/l <35S>-TBPS in the presence of title comp. at 22 deg C for 90 min

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.0500000 mM

Qualitative Results

title comp. exhibited biphasic effect on <35S>-TBPS binding to cortical synaptoneurosomes: at conc. < 1 μmol/l - increased and at conc. > 1 μmol/l - inhibited (diagram)

Measurement Parameter

Qualitative

Masonis; McCarthy; Journal of Pharmacology and Experimental Therapeutics; vol. 279; nb. 1; (1996); p. 186 - 193, View in Reaxys 35 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : Sprague-Dawley rat cortical synaptoneurosomesBioassay : radioactivity quantitation using liquid scintillation spectrometry rats (4-5 wk); purified cerebrocortical membranes were incubated with 5 nmol/l <35S>-TBPS in the presence of title comp. and 0.025-5 μmol/l GABA at 22 deg C for 90 min

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

50 mM

Measurement Parameter

IC50

Unit

µM

Quantitative value

0.95

Measurement pX

6.02

Masonis; McCarthy; Journal of Pharmacology and Experimental Therapeutics; vol. 279; nb. 1; (1996); p. 186 - 193, View in Reaxys 36 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : Sprague-Dawley rat cortical synaptoneurosomesBioassay : radioactivity quantitation using liquid scintillation spectrometry rats (4-5 wk); purified cerebrocortical membranes were incubated with 5 nmol/l <35S>-TBPS in the presence of title comp. and 1 μmol/l GABA at 22 deg C for 90 min

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.0500000 mM

Measurement Parameter

IC50

Unit

µM

Quantitative value

0.238

Measurement pX

6.62

Masonis; McCarthy; Journal of Pharmacology and Experimental Therapeutics; vol. 279; nb. 1; (1996); p. 186 - 193, View in Reaxys 37 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

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Bioassay Details

Effect : |receptor; binding activity Target : Sprague-Dawley rat cortical synaptoneurosomesBioassay : radioactivity quantitation using liquid scintillation spectrometry rats 4-5 wk; cerebral cortices were homogenized in HEPES/Tris buffer, pH 7.0; incubated with title comp. at 30 deg C in influx buffer containing 0.3 μCi <36Cl-> with increasing concentrations of GABA

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

10 µM

Measurement Parameter

EC50

Unit

µM

Quantitative value

13.7

Measurement pX

4.86

Masonis; McCarthy; Journal of Pharmacology and Experimental Therapeutics; vol. 279; nb. 1; (1996); p. 186 - 193, View in Reaxys 38 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : Sprague-Dawley rat cortical synaptoneurosomesBioassay : radioactivity quantitation using liquid scintillation spectrometry rats 4-5 wk; cerebral cortices were homogenized in HEPES/Tris-buffer, pH 7.0, pre-incubated with title comp. (4 deg C 10 min, 30 deg C 5 min), then incubated in the presence of GABA (30 deg C 5 min) in influx buffer containing 0.3 μCi <36Cl->

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

10 µM

Measurement Parameter

EC50

Unit

µM

Quantitative value

20.6

Measurement pX

4.69

Masonis; McCarthy; Journal of Pharmacology and Experimental Therapeutics; vol. 279; nb. 1; (1996); p. 186 - 193, View in Reaxys 39 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor blocking agent Target : Sprague-Dawley rat cortical synaptoneurosomesBioassay : radioactivity quantitation using liquid scintillation spectrometry rats 4-5 wk; cortices were homogenized in HEPES/Tris buffer, pH 7.0, pre-incubated with title comp. and 50 μmol/l stanozolol (4 deg C 10 min),incubated with GABA at 30 deg C 5 min in influx buffer containing 0.3 μCi <36Cl>

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

10 µM

Measurement Parameter

EC50

Unit

µM

Quantitative value

18.2

Measurement pX

4.74

Masonis; McCarthy; Journal of Pharmacology and Experimental Therapeutics; vol. 279; nb. 1; (1996); p. 186 - 193, View in Reaxys 40 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor blocking agent Target : Sprague-Dawley rat cortical synaptoneurosomesBioassay : radioactivity quantitation using liquid scintillation spectrometry rats 4-5 wk; cortices were homo-

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genized in HEPES/Tris buffer, pH 7.0, pre-incubated with 5 μmol/l stanozolol (4 deg C 10 min), then incubated with title comp. and increasing conc. of GABA at 30 deg C 5 min in influx buffer containing 0.3 μCi <36Cl-> Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

10 µM

Measurement Parameter

EC50

Unit

µM

Quantitative value

20.2

Measurement pX

4.69

Masonis; McCarthy; Journal of Pharmacology and Experimental Therapeutics; vol. 279; nb. 1; (1996); p. 186 - 193, View in Reaxys 41 of 976

42 of 976

Target Name

Cytochrome P450 2C19 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase

Target Uniprot ID

p33261

Target PDB ID

4gqs

Target, Subunit, Species

Cytochrome P450 2C19 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

25 µM

Measurement Parameter

IC50

Unit

µM

Quantitative value

635

Measurement pX

3.2

Metabolite RN

8439890

Metabolite name

5-Hydroxyomeprazole

Concomitants: Compound RN

19279336; 3628192

Concomitants: Compound name

NADPH regenerating System; Omeprazole

Concomitants: Compound role

COM; SUB

Substance Action on Target

Radioligand (/ligand)

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43 of 976

44 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

neocortex

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flunitrazepam

Measurement Parameter

Bmax

Unit

fmol/mg protein

Quantitative value

4239

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

neocortex

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flunitrazepam

Measurement Parameter

Kd

Unit

nM

Quantitative value

22

Measurement pX

7.66

Target Name

Cytochrome P450 2E1 [human]

Target Synonyms

4-nitrophenol 2-hydroxylase; cyp2e; cyp2e1; cypiie1; cytochrome p450 2e1; cytochrome p450-j

Target Uniprot ID

p05181

Target PDB ID

3e4e; 3e6i; 3gph; 3koh; 3lc4; 3t3z

Target, Subunit, Species

Cytochrome P450 2E1 [human]

Target Mutant/Chimera Details

Cytochrome P450 2E1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

1000 µM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

10

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45 of 976

46 of 976

Measurement pX

1

Metabolite RN

1867508

Metabolite name

4-nitrocatechol

Concomitants: Compound RN

24140787; 1281877; 3885115; 84272

Concomitants: Compound name

Glucose-6-phosphate; p-Nitrophenol; NADP; L-(+)-Ascorbic acid

Concomitants: Compound role

COM; SUB; COE; COM

Target Name

Cytochrome P450 2E1 [human]

Target Synonyms

4-nitrophenol 2-hydroxylase; cyp2e; cyp2e1; cypiie1; cytochrome p450 2e1; cytochrome p450-j

Target Uniprot ID

p05181

Target PDB ID

3e4e; 3e6i; 3gph; 3koh; 3lc4; 3t3z

Target, Subunit, Species

Cytochrome P450 2E1 [human]

Target Mutant/Chimera Details

Cytochrome P450 2E1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

250 µM

Measurement Parameter

% Inhibition

Unit

%

Qualitative value

<

Quantitative value

10

Measurement pX

1

Metabolite RN

1867508

Metabolite name

4-nitrocatechol

Concomitants: Compound RN

24140787; 1281877; 3885115; 84272

Concomitants: Compound name

Glucose-6-phosphate; p-Nitrophenol; NADP; L-(+)-Ascorbic acid

Concomitants: Compound role

COM; SUB; COE; COM

Target Name

Cytochrome P450 2C19 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase

Target Uniprot ID

p33261

Target PDB ID

4gqs

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47 of 976

Target, Subunit, Species

Cytochrome P450 2C19 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Clint

Unit

µL/min/mg protein

Measurement Object

HIGH

Quantitative value

8.559

Metabolite RN

688458

Metabolite name

Desmethylflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 2C19 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase

Target Uniprot ID

p33261

Target PDB ID

4gqs

Target, Subunit, Species

Cytochrome P450 2C19 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Clint

Unit

µL/min/mg protein

Measurement Object

LOW

Quantitative value

1.341

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48 of 976

49 of 976

Metabolite RN

713494

Metabolite name

3-Hydroxyflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6alpha-hydroxylase

Target Uniprot ID

p33261 + p08684

Target PDB ID

4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human

Target Transfection

Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Clint

Unit

µL/min/mg protein

Measurement Object

HIGH

Quantitative value

1.494

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole mono-

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oxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6alpha-hydroxylase

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Target Uniprot ID

p33261 + p08684

Target PDB ID

4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human

Target Transfection

Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Clint

Unit

µL/min/mg protein

Measurement Object

HIGH

Quantitative value

1.762

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6alpha-hydroxylase

Target Uniprot ID

p33261 + p08684

Target PDB ID

4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human

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51 of 976

Target Transfection

Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Clint

Unit

µL/min/mg protein

Measurement Object

LOW

Quantitative value

1.036

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6alpha-hydroxylase

Target Uniprot ID

p33261 + p08684

Target PDB ID

4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human

Target Transfection

Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

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52 of 976

53 of 976

Measurement Parameter

Clint

Unit

µL/min/mg protein

Measurement Object

LOW

Quantitative value

1.586

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 2C19 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase

Target Uniprot ID

p33261

Target PDB ID

4gqs

Target, Subunit, Species

Cytochrome P450 2C19 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Vmax

Unit

nmol/min/mg protein

Measurement Object

HIGH

Quantitative value

0.095

Metabolite RN

688458

Metabolite name

Desmethylflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 2C19 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase

Target Uniprot ID

p33261

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54 of 976

Target PDB ID

4gqs

Target, Subunit, Species

Cytochrome P450 2C19 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Km

Unit

µM

Measurement Object

HIGH

Quantitative value

11.1

Measurement pX

4.95

Metabolite RN

688458

Metabolite name

Desmethylflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Vmax

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55 of 976

56 of 976

Unit

nmol/min/mg protein

Measurement Object

LOW

Quantitative value

1.27

Metabolite RN

688458

Metabolite name

Desmethylflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Km

Unit

µM

Measurement Object

LOW

Quantitative value

108

Measurement pX

3.97

Metabolite RN

688458

Metabolite name

Desmethylflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 2C19 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase

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Target Uniprot ID

p33261

Target PDB ID

4gqs

Target, Subunit, Species

Cytochrome P450 2C19 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Vmax

Unit

nmol/min/mg protein

Measurement Object

LOW

Quantitative value

0.861

Metabolite RN

713494

Metabolite name

3-Hydroxyflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 2C19 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase

Target Uniprot ID

p33261

Target PDB ID

4gqs

Target, Subunit, Species

Cytochrome P450 2C19 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Km

Unit

µM

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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59 of 976

Measurement Object

LOW

Quantitative value

642

Measurement pX

3.19

Metabolite RN

713494

Metabolite name

3-Hydroxyflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Vmax

Unit

nmol/min/mg protein

Measurement Object

HIGH

Quantitative value

0.42

Metabolite RN

713494

Metabolite name

3-Hydroxyflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

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Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Km

Unit

µM

Measurement Object

HIGH

Quantitative value

34

Measurement pX

4.47

Metabolite RN

713494

Metabolite name

3-Hydroxyflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6alpha-hydroxylase

Target Uniprot ID

p33261 + p08684

Target PDB ID

4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human

Target Transfection

Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

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Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Vmax

Unit

nmol/min/mg protein

Measurement Object

HIGH

Quantitative value

0.13

Deviation

0.0200000

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6alpha-hydroxylase

Target Uniprot ID

p33261 + p08684

Target PDB ID

4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human

Target Transfection

Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Vmax

Unit

nmol/min/mg protein

Measurement Object

HIGH

Quantitative value

0.074

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Deviation

0.0340000

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6alpha-hydroxylase

Target Uniprot ID

p33261 + p08684

Target PDB ID

4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human

Target Transfection

Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Km

Unit

µM

Measurement Object

HIGH

Quantitative value

42

Deviation

17

Measurement pX

4.38

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

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64 of 976

Target Name

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6alpha-hydroxylase

Target Uniprot ID

p33261 + p08684

Target PDB ID

4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human

Target Transfection

Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Km

Unit

µM

Measurement Object

HIGH

Quantitative value

87

Deviation

20

Measurement pX

4.06

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6alpha-hydroxylase

Target Uniprot ID

p33261 + p08684

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Target PDB ID

4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human

Target Transfection

Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Vmax

Unit

nmol/min/mg protein

Measurement Object

LOW

Quantitative value

0.171

Deviation

0.100000

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6alpha-hydroxylase

Target Uniprot ID

p33261 + p08684

Target PDB ID

4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human

Target Transfection

Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

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Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Vmax

Unit

nmol/min/mg protein

Measurement Object

LOW

Quantitative value

0.46

Deviation

0.151000

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6alpha-hydroxylase

Target Uniprot ID

p33261 + p08684

Target PDB ID

4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human

Target Transfection

Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Km

Unit

µM

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Measurement Object

LOW

Quantitative value

165

Deviation

101

Measurement pX

3.78

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6alpha-hydroxylase

Target Uniprot ID

p33261 + p08684

Target PDB ID

4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human

Target Transfection

Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Km

Unit

µM

Measurement Object

LOW

Quantitative value

290

Deviation

84

Measurement pX

3.54

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

77911

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69 of 976

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 2D6 [human]

Target Synonyms

cholesterol 25-hydroxylase; cyp2d6; cyp2dl1; cypiid6; cytochrome p450 2d6; cytochrome p450db1; debrisoquine 4-hydroxylase

Target Uniprot ID

p10635

Target PDB ID

2f9q; 3qm4; 3tbg; 3tda; 4wnt; 4wnu; 4wnv; 4wnw; 4xry; 4xrz; 5tft; 5tfu

Target, Subunit, Species

Cytochrome P450 2D6 [human]

Target Mutant/Chimera Details

Cytochrome P450 2D6 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Rate

Qualitative value

NA

Measurement pX

1

Metabolite RN

688458

Metabolite name

Desmethylflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 2E1 [human]

Target Synonyms

4-nitrophenol 2-hydroxylase; cyp2e; cyp2e1; cypiie1; cytochrome p450 2e1; cytochrome p450-j

Target Uniprot ID

p05181

Target PDB ID

3e4e; 3e6i; 3gph; 3koh; 3lc4; 3t3z

Target, Subunit, Species

Cytochrome P450 2E1 [human]

Target Mutant/Chimera Details

Cytochrome P450 2E1 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

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Measurement Parameter

Rate

Qualitative value

NA

Measurement pX

1

Metabolite RN

713494

Metabolite name

3-Hydroxyflunitrazepam

Concomitants: Compound RN

77911

Concomitants: Compound name

NADPH

Concomitants: Compound role

COE

Target Name

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

cholesterol 25-hydroxylase; cyp1a2; cypia2; cytochrome p(3)450; cytochrome p450 1a2; cytochrome p450 4; cytochrome p450-p3 + (r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p05177 + p33261 + p08684

Target PDB ID

2hi4 + 4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 1A2 [human]:Wild; Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human; human

Target Transfection

Non Transfected; Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

25 µM

Measurement Parameter

nH

Quantitative value

2

Deviation

0.400000

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3'-Hydroxyflunitrazepam

Concomitants: Compound RN

19279336; 506008

Concomitants: Compound name

NADPH regenerating System; DMSO

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71 of 976

72 of 976

Concomitants: Compound role

COE; SLV

Target Name

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

cholesterol 25-hydroxylase; cyp1a2; cypia2; cytochrome p(3)450; cytochrome p450 1a2; cytochrome p450 4; cytochrome p450-p3 + (r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p05177 + p33261 + p08684

Target PDB ID

2hi4 + 4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 1A2 [human]:Wild; Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human; human

Target Transfection

Non Transfected; Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

25 µM

Measurement Parameter

nH

Quantitative value

2.7

Deviation

0.500000

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3'-Hydroxyflunitrazepam

Concomitants: Compound RN

19279336; 506008

Concomitants: Compound name

NADPH regenerating System; DMSO

Concomitants: Compound role

COE; SLV

Target Name

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

cholesterol 25-hydroxylase; cyp1a2; cypia2; cytochrome p(3)450; cytochrome p450 1a2; cytochrome p450 4; cytochrome p450-p3 + (r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

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Target Uniprot ID

p05177 + p33261 + p08684

Target PDB ID

2hi4 + 4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 1A2 [human]:Wild; Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human; human

Target Transfection

Non Transfected; Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

25 µM

Measurement Parameter

nH

Quantitative value

1.8

Deviation

0.700000

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3'-Hydroxyflunitrazepam

Concomitants: Compound RN

19279336; 741857

Concomitants: Compound name

NADPH regenerating System; Acetonitrile

Concomitants: Compound role

COE; SLV

Target Name

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

cholesterol 25-hydroxylase; cyp1a2; cypia2; cytochrome p(3)450; cytochrome p450 1a2; cytochrome p450 4; cytochrome p450-p3 + (r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p05177 + p33261 + p08684

Target PDB ID

2hi4 + 4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 1A2 [human]:Wild; Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human; human

Target Transfection

Non Transfected; Non Transfected; Non Transfected

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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74 of 976

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

25 µM

Measurement Parameter

nH

Quantitative value

2.6

Deviation

1.10000

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3'-Hydroxyflunitrazepam

Concomitants: Compound RN

19279336; 741857

Concomitants: Compound name

NADPH regenerating System; Acetonitrile

Concomitants: Compound role

COE; SLV

Target Name

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

cholesterol 25-hydroxylase; cyp1a2; cypia2; cytochrome p(3)450; cytochrome p450 1a2; cytochrome p450 4; cytochrome p450-p3 + (r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p05177 + p33261 + p08684

Target PDB ID

2hi4 + 4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 1A2 [human]:Wild; Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human; human

Target Transfection

Non Transfected; Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

25 µM

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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75 of 976

Measurement Parameter

S50

Unit

µM

Quantitative value

249

Deviation

69.5000

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3'-Hydroxyflunitrazepam

Concomitants: Compound RN

19279336; 506008

Concomitants: Compound name

NADPH regenerating System; DMSO

Concomitants: Compound role

COE; SLV

Target Name

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

cholesterol 25-hydroxylase; cyp1a2; cypia2; cytochrome p(3)450; cytochrome p450 1a2; cytochrome p450 4; cytochrome p450-p3 + (r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p05177 + p33261 + p08684

Target PDB ID

2hi4 + 4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 1A2 [human]:Wild; Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human; human

Target Transfection

Non Transfected; Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

25 µM

Measurement Parameter

S50

Unit

µM

Quantitative value

286

Deviation

95

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3'-Hydroxyflunitrazepam

Concomitants: Compound RN

19279336; 506008

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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76 of 976

77 of 976

Concomitants: Compound name

NADPH regenerating System; DMSO

Concomitants: Compound role

COE; SLV

Target Name

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

cholesterol 25-hydroxylase; cyp1a2; cypia2; cytochrome p(3)450; cytochrome p450 1a2; cytochrome p450 4; cytochrome p450-p3 + (r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p05177 + p33261 + p08684

Target PDB ID

2hi4 + 4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 1A2 [human]:Wild; Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human; human

Target Transfection

Non Transfected; Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

25 µM

Measurement Parameter

Vmax

Unit

nmol/h/mg protein

Quantitative value

5.9

Deviation

2.60000

Statistical sgnificance (pvalue)

0.008

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3'-Hydroxyflunitrazepam

Concomitants: Compound RN

19279336; 506008

Concomitants: Compound name

NADPH regenerating System; DMSO

Concomitants: Compound role

COE; SLV

Target Name

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

cholesterol 25-hydroxylase; cyp1a2; cypia2; cytochrome p(3)450; cytochrome p450 1a2; cytochrome p450 4; cytochrome p450-p3 + (r)-limonene 6-monooxygenase; (s)-limonene 6-monooxy-

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genase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

78 of 976

Target Uniprot ID

p05177 + p33261 + p08684

Target PDB ID

2hi4 + 4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 1A2 [human]:Wild; Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human; human

Target Transfection

Non Transfected; Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

25 µM

Measurement Parameter

Vmax

Unit

nmol/h/mg protein

Quantitative value

42.4

Deviation

24.5000

Statistical sgnificance (pvalue)

0.008

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3'-Hydroxyflunitrazepam

Concomitants: Compound RN

19279336; 506008

Concomitants: Compound name

NADPH regenerating System; DMSO

Concomitants: Compound role

COE; SLV

Target Name

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

cholesterol 25-hydroxylase; cyp1a2; cypia2; cytochrome p(3)450; cytochrome p450 1a2; cytochrome p450 4; cytochrome p450-p3 + (r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p05177 + p33261 + p08684

Target PDB ID

2hi4 + 4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

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Target, Subunit, Species

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 1A2 [human]:Wild; Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human; human

Target Transfection

Non Transfected; Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

25 µM

Measurement Parameter

S50

Unit

µM

Quantitative value

313

Deviation

242

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3'-Hydroxyflunitrazepam

Concomitants: Compound RN

19279336; 741857

Concomitants: Compound name

NADPH regenerating System; Acetonitrile

Concomitants: Compound role

COE; SLV

Target Name

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

cholesterol 25-hydroxylase; cyp1a2; cypia2; cytochrome p(3)450; cytochrome p450 1a2; cytochrome p450 4; cytochrome p450-p3 + (r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p05177 + p33261 + p08684

Target PDB ID

2hi4 + 4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 1A2 [human]:Wild; Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human; human

Target Transfection

Non Transfected; Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

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Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

25 µM

Measurement Parameter

S50

Unit

µM

Quantitative value

201

Deviation

27.1000

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3'-Hydroxyflunitrazepam

Concomitants: Compound RN

19279336; 741857

Concomitants: Compound name

NADPH regenerating System; Acetonitrile

Concomitants: Compound role

COE; SLV

Target Name

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

cholesterol 25-hydroxylase; cyp1a2; cypia2; cytochrome p(3)450; cytochrome p450 1a2; cytochrome p450 4; cytochrome p450-p3 + (r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p05177 + p33261 + p08684

Target PDB ID

2hi4 + 4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 1A2 [human]:Wild; Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human; human

Target Transfection

Non Transfected; Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

25 µM

Measurement Parameter

Vmax

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Unit

nmol/h/mg protein

Quantitative value

21.8

Deviation

20.1000

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3'-Hydroxyflunitrazepam

Concomitants: Compound RN

19279336; 741857

Concomitants: Compound name

NADPH regenerating System; Acetonitrile

Concomitants: Compound role

COE; SLV

Target Name

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Synonyms

cholesterol 25-hydroxylase; cyp1a2; cypia2; cytochrome p(3)450; cytochrome p450 1a2; cytochrome p450 4; cytochrome p450-p3 + (r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase + 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p05177 + p33261 + p08684

Target PDB ID

2hi4 + 4gqs + 1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 1A2 [human]; Cytochrome P450 2C19 [human]; Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 1A2 [human]:Wild; Cytochrome P450 2C19 [human]:Wild; Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human; human; human

Target Transfection

Non Transfected; Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

25 µM

Measurement Parameter

Vmax

Unit

nmol/h/mg protein

Quantitative value

101

Deviation

71.4000

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3'-Hydroxyflunitrazepam

Concomitants: Compound RN

19279336; 741857

Concomitants: Compound name

NADPH regenerating System; Acetonitrile

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83 of 976

Concomitants: Compound role

COE; SLV

Target Name

5-hydroxytryptamine receptor [Rattus norvegicus]; GABA-A receptor [Rattus norvegicus]

Target Synonyms

5-hydroxytryptamine receptor + gaba-a receptor

Target, Subunit, Species

5-hydroxytryptamine receptor [Rattus norvegicus]; GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

5-hydroxytryptamine receptor [Rattus norvegicus]:Wild; GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus; Rattus norvegicus

Target Transfection

Non Transfected; Non Transfected

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Specific behaviour

Biological Species/NCBI ID

Sprague Dawley rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

%

Unit

%

Measurement Object

incidence (shakes) (Wet Dog Shakes)

Quantitative value

25

Target Name

5-hydroxytryptamine receptor [Rattus norvegicus]; GABA-A receptor [Rattus norvegicus]

Target Synonyms

5-hydroxytryptamine receptor + gaba-a receptor

Target, Subunit, Species

5-hydroxytryptamine receptor [Rattus norvegicus]; GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

5-hydroxytryptamine receptor [Rattus norvegicus]:Wild; GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus; Rattus norvegicus

Target Transfection

Non Transfected; Non Transfected

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Specific behaviour

Biological Species/NCBI ID

Sprague Dawley rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 mg/kg

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

%

Unit

%

Measurement Object

incidence (shakes) (Wet Dog Shakes)

Quantitative value

88

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84 of 976

85 of 976

86 of 976

Target Name

5-hydroxytryptamine receptor [Rattus norvegicus]; GABA-A receptor [Rattus norvegicus]

Target Synonyms

5-hydroxytryptamine receptor + gaba-a receptor

Target, Subunit, Species

5-hydroxytryptamine receptor [Rattus norvegicus]; GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

5-hydroxytryptamine receptor [Rattus norvegicus]:Wild; GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus; Rattus norvegicus

Target Transfection

Non Transfected; Non Transfected

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Specific behaviour

Biological Species/NCBI ID

Sprague Dawley rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

20 mg/kg

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

%

Unit

%

Measurement Object

incidence (shakes) (Wet Dog Shakes)

Quantitative value

100

Target Name

5-hydroxytryptamine receptor [Rattus norvegicus]; GABA-A receptor [Rattus norvegicus]

Target Synonyms

5-hydroxytryptamine receptor + gaba-a receptor

Target, Subunit, Species

5-hydroxytryptamine receptor [Rattus norvegicus]; GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

5-hydroxytryptamine receptor [Rattus norvegicus]:Wild; GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus; Rattus norvegicus

Target Transfection

Non Transfected; Non Transfected

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Specific behaviour

Biological Species/NCBI ID

Sprague Dawley rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

60 mg/kg

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

%

Unit

%

Measurement Object

incidence (shakes) (Wet Dog Shakes)

Quantitative value

100

Target Name

5-hydroxytryptamine receptor [Rattus norvegicus]; GABA-A receptor [Rattus norvegicus]

Target Synonyms

5-hydroxytryptamine receptor + gaba-a receptor

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87 of 976

88 of 976

Target, Subunit, Species

5-hydroxytryptamine receptor [Rattus norvegicus]; GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

5-hydroxytryptamine receptor [Rattus norvegicus]:Wild; GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus; Rattus norvegicus

Target Transfection

Non Transfected; Non Transfected

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Specific behaviour

Biological Species/NCBI ID

Sprague Dawley rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

shakes per 30 min. (Wet Dog Shakes)

Quantitative value

6.4

Deviation

4.10000

Target Name

5-hydroxytryptamine receptor [Rattus norvegicus]; GABA-A receptor [Rattus norvegicus]

Target Synonyms

5-hydroxytryptamine receptor + gaba-a receptor

Target, Subunit, Species

5-hydroxytryptamine receptor [Rattus norvegicus]; GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

5-hydroxytryptamine receptor [Rattus norvegicus]:Wild; GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus; Rattus norvegicus

Target Transfection

Non Transfected; Non Transfected

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Specific behaviour

Biological Species/NCBI ID

Sprague Dawley rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 mg/kg

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

shakes per 30 min. (Wet Dog Shakes)

Quantitative value

28.7

Deviation

3.20000

Statistical sgnificance (pvalue)

0.05

Target Name

5-hydroxytryptamine receptor [Rattus norvegicus]; GABA-A receptor [Rattus norvegicus]

Target Synonyms

5-hydroxytryptamine receptor + gaba-a receptor

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89 of 976

Target, Subunit, Species

5-hydroxytryptamine receptor [Rattus norvegicus]; GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

5-hydroxytryptamine receptor [Rattus norvegicus]:Wild; GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus; Rattus norvegicus

Target Transfection

Non Transfected; Non Transfected

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Specific behaviour

Biological Species/NCBI ID

Sprague Dawley rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

20 mg/kg

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

shakes per 30 min. (Wet Dog Shakes)

Quantitative value

48

Deviation

9.50000

Statistical sgnificance (pvalue)

0.05

Target Name

5-hydroxytryptamine receptor [Rattus norvegicus]; GABA-A receptor [Rattus norvegicus]

Target Synonyms

5-hydroxytryptamine receptor + gaba-a receptor

Target, Subunit, Species

5-hydroxytryptamine receptor [Rattus norvegicus]; GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

5-hydroxytryptamine receptor [Rattus norvegicus]:Wild; GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus; Rattus norvegicus

Target Transfection

Non Transfected; Non Transfected

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Specific behaviour

Biological Species/NCBI ID

Sprague Dawley rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

60 mg/kg

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

shakes per 30 min. (Wet Dog Shakes)

Quantitative value

47.7

Deviation

2.20000

Statistical sgnificance (pvalue)

0.05

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90 of 976

Bioassay Category

Metabolism/Transport

Bioassay Name

Binding

Biological Species/NCBI ID

Sprague Dawley rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1.25000 mg/kg

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

BB ratio

Measurement Object

Concentration

Quantitative value

1.15

Metabolite RN

899031; 899030; 754932

Metabolite name

1'-Hydroxymidazolam; 4-Hydroxymidazolam; N-Desmethylclobazam

Arendt; Greenblatt; Liebisch; Luu; Paul; Psychopharmacology; vol. 93; nb. 1; (1987); p. 72 - 76, View in Reaxys 91 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Sprague Dawley rat

Organs/Tissues

brain cortex

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

1.66

Measurement pX

8.78

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

RAD

Arendt; Greenblatt; Liebisch; Luu; Paul; Psychopharmacology; vol. 93; nb. 1; (1987); p. 72 - 76, View in Reaxys 92 of 976

Bioassay Category

Metabolism/Transport

Bioassay Name

Binding

Biological Species/NCBI ID

Sprague Dawley rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1.25000 mg/kg

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

fu

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Quantitative value

0.193

Metabolite RN

899031; 899030; 754932

Metabolite name

1'-Hydroxymidazolam; 4-Hydroxymidazolam; N-Desmethylclobazam

Arendt; Greenblatt; Liebisch; Luu; Paul; Psychopharmacology; vol. 93; nb. 1; (1987); p. 72 - 76, View in Reaxys 93 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Healthy

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dosing Regimen

Single

Measurement Parameter

Fa(%)

Unit

%

Quantitative value

90

Bergstroem, Christel A. S.; Strafford, Melissa; Lazorova, Lucia; Avdeef, Alex; Luthman, Kristina; Artursson, Per; Journal of Medicinal Chemistry; vol. 46; nb. 4; (2003); p. 558 - 570, View in Reaxys 94 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

reduction of the increase of HVA induced by chlorpromazine (male mice, 1 mg/kg, i.p.)

Measurement Parameter

Qualitative

Pieri; Schaffner; Scherschlicht; Polc; Sepinwall; Davidson; Moehler; Cumin; Da Prada; Burkard; Keller; Mueller; Gerold; Cook; Haefely; Arzneimittel-Forschung/Drug Research; vol. 31; nb. 12 a; (1981); p. 2180 - 2201, View in Reaxys 95 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |pharmacokinetics Target : human liver microsomesBioassay : CLint: intrinsic clearance CLint determined for both oxidative pathways and summed to give CLint

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

CLint: 5.9 μL/min/mg protein

Measurement Parameter

Qualitative

Hakooz, Nancy; Ito, Kiyomi; Rawden, Helen; Gill, Helen; Lemmers, Lynn; Boobis, Alan R.; Edwards, Robert J.; Carlile, David J.; Lake, Brian G.; Houston, J. Brian; Pharmaceutical Research; vol. 23; nb. 3; (2006); p. 533 - 539, View in Reaxys 96 of 976

Substance Effect

Analgesic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Target : Crl:CD-1(ICR)BR miceBioassay : percent = 100 * number of nonresponders / number in group in vivo; Crl:CD-1(ICR)BR mice (18-25 g) grouphoused (5-15/cage); title comp. was given 30 min before i.p. injection of endothelin-1 (0.1 mg/kg); single abdominal constriction response recorded

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Route of Adm.

oral administration

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Qualitative Results

less than 50 percent antagonism at the maximum dose (10 mg/kg) applied

Measurement Parameter

Qualitative

Raffa, Robert B.; Schupsky, James J.; Lee, David K. H.; Jacoby, Henry I.; Journal of Pharmacology and Experimental Therapeutics; vol. 278; nb. 1; (1996); p. 1 - 7, View in Reaxys 97 of 976

Target Name

endothelin receptor [human]

Target Synonyms

endothelin receptor

Target, Subunit, Species

endothelin receptor [human]

Target Mutant/Chimera Details

endothelin receptor [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor blocking agent Bioassay : SPA=scintillation proximity assay in vitro; SPA kit with endothelin preparation from human placental membrane was used; binding of 125I-endothelin (2,000 Ci/mmol) measured

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

100 µM

Measurement Parameter

Qualitative

Qualitative value

NA

Measurement pX

1

Raffa, Robert B.; Schupsky, James J.; Lee, David K. H.; Jacoby, Henry I.; Journal of Pharmacology and Experimental Therapeutics; vol. 278; nb. 1; (1996); p. 1 - 7, View in Reaxys 98 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Bioassay Details

Effect : |receptor; binding activity Target : Wistar rat cortex homogenateBioassay : nonspecific binding was determined in the presence of unlabeled flumazenil; Ki: affinity of the displacer GABAA receptor binding determined by displacement of <3H>flumazenil; brain cortex homogenate incubated with title comp. and <3H>flumazenil for 35 min at 37 deg C with/without 50 μmol/l GABA; sample filtered and radioactivity on filter determined

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

Ki

Unit

µg/L

Quantitative value

9.8

Measurement pX

7.5

Visser; Wolters; Gubbens-Stibbe; Tukker; Van Der Graaf; Peletier; Danhof, Meindert; Journal of Pharmacology and Experimental Therapeutics; vol. 304; nb. 1; (2003); p. 88 - 101, View in Reaxys 99 of 976

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Effect : |pharmacokinetics Bioassay : control: vehicle; PK/PD: pharmacokinetic - pharmacodynamic model; PK/PD model converged yielding estimates of both in vivo receptor affinity (KPD) and in vivo intrinsic efficacy (ePD) conc.-effect relationships; arterial blood samples taken in time points after title comp. injection; plasma conc. of title comp. determined by HPLC with UV detection; pharmacodynamics estimated by recording EEG (electroencephalogram) parameters

Biological Species/NCBI ID

Rattus norvegicus

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Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

2.20000 mg/kg

Substance Route of Adm.

intravenous administration

Qualitative Results

title comp. PK/PD modeling revealed monophasic concentration-EEG effect relationships with potency (EC50) 35.5 ng/ml and intrinsic activity 9.3 μV; KPD = 9.5 ng/ml and ePD = 0.50

Measurement Parameter

Qualitative

Visser; Wolters; Gubbens-Stibbe; Tukker; Van Der Graaf; Peletier; Danhof, Meindert; Journal of Pharmacology and Experimental Therapeutics; vol. 304; nb. 1; (2003); p. 88 - 101, View in Reaxys 100 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |protein binding Bioassay : fu: free fraction, was calculated by dividing of free title comp. conc. in ultrafiltrate by total (bound and free) conc. in plasma blood was spiked with title comp. and placed in water bath at 37 deg C for 30 min; then blood samples were hemolyzed and centrifuged using ultrafiltration device; conc. of title comp. in the blood, plasma and ultrafiltrate was measured by HPLC

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

fu

Quantitative value

26.6

Visser; Wolters; Gubbens-Stibbe; Tukker; Van Der Graaf; Peletier; Danhof, Meindert; Journal of Pharmacology and Experimental Therapeutics; vol. 304; nb. 1; (2003); p. 88 - 101, View in Reaxys 101 of 976

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Epsilon) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (epsilon) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Epsilon) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Epsilon) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

% Inhibition

Unit

%

Measurement Object

of GABA EC20

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102 of 976

103 of 976

Quantitative value

0

Measurement pX

1

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p28472 + p14867

Target PDB ID

4cof

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

# 220 nM

Measurement Parameter

% Stimulation

Unit

%

Measurement Object

of GABA EC20

Quantitative value

121

Deviation

9.30000

Measurement pX

7.94

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p28472 + p14867

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Target PDB ID

4cof

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.2

Measurement pX

8.66

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In Vivo: Binding

Biological Species/NCBI ID

Sprague Dawley rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

ID50

Unit

mg/kg

Quantitative value

2.1

Deviation

0.400000

Concomitants: Compound RN

4763661; 4763661

Concomitants: Compound name

Flumazenil; [3H]-Ro 15-1788

Concomitants: Compound role

OCV; OCV

Benavides; Peny; Durand; Arbilla; Scatton; Journal of Pharmacology and Experimental Therapeutics; vol. 263; nb. 2; (1992); p. 884 - 896, View in Reaxys 105 of 976

Bioassay Category

In Vivo (Animal models)

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Bioassay Name

In Vivo: Binding

Biological Species/NCBI ID

Sprague Dawley rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

ID50

Unit

mg/kg

Quantitative value

2.5

Deviation

0.400000

Concomitants: Compound RN

4763661; 4763661

Concomitants: Compound name

Flumazenil; [3H]-Ro 15-1788

Concomitants: Compound role

OCV; OCV

Benavides; Peny; Durand; Arbilla; Scatton; Journal of Pharmacology and Experimental Therapeutics; vol. 263; nb. 2; (1992); p. 884 - 896, View in Reaxys 106 of 976

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In Vivo: Binding

Biological Species/NCBI ID

Sprague Dawley rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

ID50

Unit

mg/kg

Quantitative value

2.6

Deviation

0.600000

Concomitants: Compound RN

4763661; 4763661

Concomitants: Compound name

Flumazenil; [3H]-Ro 15-1788

Concomitants: Compound role

OCV; OCV

Benavides; Peny; Durand; Arbilla; Scatton; Journal of Pharmacology and Experimental Therapeutics; vol. 263; nb. 2; (1992); p. 884 - 896, View in Reaxys 107 of 976

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In Vivo: Binding

Biological Species/NCBI ID

Sprague Dawley rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Route of Adm.

intraperitoneal administration

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Substance Dosing Regimen

Single

Measurement Parameter

ID50

Unit

mg/kg

Quantitative value

2.8

Deviation

0.600000

Concomitants: Compound RN

4763661; 4763661

Concomitants: Compound name

Flumazenil; [3H]-Ro 15-1788

Concomitants: Compound role

OCV; OCV

Benavides; Peny; Durand; Arbilla; Scatton; Journal of Pharmacology and Experimental Therapeutics; vol. 263; nb. 2; (1992); p. 884 - 896, View in Reaxys 108 of 976

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In Vivo: Binding

Biological Species/NCBI ID

Sprague Dawley rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

ID50

Unit

mg/kg

Quantitative value

3.5

Deviation

0.800000

Concomitants: Compound RN

4763661; 4763661

Concomitants: Compound name

Flumazenil; [3H]-Ro 15-1788

Concomitants: Compound role

OCV; OCV

Benavides; Peny; Durand; Arbilla; Scatton; Journal of Pharmacology and Experimental Therapeutics; vol. 263; nb. 2; (1992); p. 884 - 896, View in Reaxys 109 of 976

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

cerebellum

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Cells/Cell Lines

nerve cell

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

IC50

Unit

nM

Measurement Object

HIGH

Quantitative value

3.9

Measurement pX

8.41

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Benavides; Peny; Durand; Arbilla; Scatton; Journal of Pharmacology and Experimental Therapeutics; vol. 263; nb. 2; (1992); p. 884 - 896, View in Reaxys 110 of 976

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

cerebellum

Cells/Cell Lines

nerve cell

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

IC50

Unit

nM

Measurement Object

LOW

Quantitative value

2.4

Measurement pX

8.62

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Benavides; Peny; Durand; Arbilla; Scatton; Journal of Pharmacology and Experimental Therapeutics; vol. 263; nb. 2; (1992); p. 884 - 896, View in Reaxys

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111 of 976

112 of 976

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit beta-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18507 + p47870 + p14867

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

7.96

Deviation

0.150000

Measurement pX

8.1

Concomitants: Compound RN

4763661

Concomitants: Compound name

[3H]-Ro 15-1788

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p28472 + p18507 + p14867

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

L-M(TK-) cell line

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113 of 976

114 of 976

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

22.44

Deviation

2.47000

Measurement pX

7.65

Concomitants: Compound RN

4763661

Concomitants: Compound name

[3H]-Ro 15-1788

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-2 [human];+Gamma-aminobutyric acid receptor subunit beta-2 [human]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-2; gabra2; gamma-aminobutyric acid receptor subunit alpha-2 + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p18507 + p47869 + p47870

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-2 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

3.34

Deviation

0.160000

Measurement pX

8.48

Concomitants: Compound RN

4763661

Concomitants: Compound name

[3H]-Ro 15-1788

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-2 [human]

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115 of 976

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-2; gabra2; gamma-aminobutyric acid receptor subunit alpha-2

Target Uniprot ID

p28472 + p18507 + p47869

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-2 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-2 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

L-M(TK-) cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

9.57

Deviation

1.59000

Measurement pX

8.02

Concomitants: Compound RN

4763661

Concomitants: Compound name

[3H]-Ro 15-1788

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit alpha-5 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit beta-2 [human]

Target Synonyms

gaba(a) receptor subunit alpha-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p31644 + p18507 + p47870

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-5 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-5 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

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117 of 976

Substance Name

flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

7.02

Deviation

0.290000

Measurement pX

8.15

Concomitants: Compound RN

4763661

Concomitants: Compound name

[3H]-Ro 15-1788

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit alpha-5 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2

Target Uniprot ID

p28472 + p31644 + p18507

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-5 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-5 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

L-M(TK-) cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

12.08

Deviation

1.33000

Measurement pX

7.92

Concomitants: Compound RN

4763661

Concomitants: Compound name

[3H]-Ro 15-1788

Concomitants: Compound role

RAD

Target Name

GABA-A receptor (Gamma 2L) [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

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118 of 976

Target Uniprot ID

p08220 + p08219

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [taurine cattle]; Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

EC50

Unit

nM

Quantitative value

29

Deviation

11.2000

Measurement pX

7.54

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 2L) [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p08220 + p08219

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [taurine cattle]; Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

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Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 2L) [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p08220 + p08219

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [taurine cattle]; Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 2L) [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p08220 + p08219

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [taurine cattle]; Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]:Wild

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Target Species (Bioactivity)

taurine cattle

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 2L) [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p08220 + p08219

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [taurine cattle]; Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 2L) [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p08220 + p08219

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [taurine cattle]; Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 2L) [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-3 [taurine cattle]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p08220 + p10064

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [taurine cattle]; Gamma-aminobutyric acid receptor subunit alpha-3 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

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125 of 976

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

EC50

Unit

nM

Quantitative value

24

Deviation

10.4000

Measurement pX

7.62

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 2L) [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-3 [taurine cattle]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p08220 + p10064

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [taurine cattle]; Gamma-aminobutyric acid receptor subunit alpha-3 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 2L) [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-3 [taurine cattle]

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Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p08220 + p10064

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [taurine cattle]; Gamma-aminobutyric acid receptor subunit alpha-3 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 2L) [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-3 [taurine cattle]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p08220 + p10064

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [taurine cattle]; Gamma-aminobutyric acid receptor subunit alpha-3 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

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128 of 976

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 2L) [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-3 [taurine cattle]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p08220 + p10064

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [taurine cattle]; Gamma-aminobutyric acid receptor subunit alpha-3 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 2L) [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-3 [taurine cattle]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p08220 + p10064

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [taurine cattle]; Gamma-aminobutyric acid receptor subunit alpha-3 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]

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Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 2L) [human];+Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

EC50

Unit

nM

Quantitative value

3.3

Deviation

0.700000

Measurement pX

8.48

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130 of 976

131 of 976

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 2L) [human];+Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

123

Deviation

3.20000

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 1) [human];+Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba-a receptor (gamma 1) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 1) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 1) [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

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Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

EC50

Unit

nM

Quantitative value

26.5

Deviation

20.3000

Measurement pX

7.58

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 1) [human];+Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba-a receptor (gamma 1) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 1) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 1) [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

81

Deviation

9.60000

Concomitants: Compound RN

906818

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134 of 976

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 2L) [human];+Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 2L) [human];+Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

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136 of 976

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 2L) [human];+Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 2L) [human];+Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

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Target, Subunit, Species

GABA-A receptor (Gamma 2L) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 1) [human];+Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba-a receptor (gamma 1) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 1) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 1) [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

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Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 1) [human];+Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba-a receptor (gamma 1) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 1) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 1) [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 1) [human];+Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba-a receptor (gamma 1) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 1) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 1) [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

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Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 1) [human];+Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba-a receptor (gamma 1) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 1) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 1) [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Quantitative value

100

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

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Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Wistar rat

Organs/Tissues

brain cortex

Cells/Cell Lines

cells

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

IC50

Unit

nM

Qualitative value

#

Quantitative value

0.79

Measurement pX

9.1

Concomitants: Compound RN

754371; 4763661; 906818

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788; GABA

Concomitants: Compound role

NSB; RAD; AGO

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Wistar rat

Organs/Tissues

brain cortex

Cells/Cell Lines

cells

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

IC50

Unit

nM

Qualitative value

#

Quantitative value

1.51

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Measurement pX

8.82

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

brain cortex

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

IC50

Unit

nM

Quantitative value

114

Measurement pX

6.94

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [mammal];+Gamma-aminobutyric acid receptor subunit gamma-2 [mammal];+Gamma-aminobutyric acid receptor subunit alpha-1 [mammal]

Target Synonyms

gamma-aminobutyric acid receptor subunit beta-3 + gamma-aminobutyric acid receptor subunit gamma-2 + gamma-aminobutyric acid receptor subunit alpha-1

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [mammal]; Gamma-aminobutyric acid receptor subunit beta-3 [mammal]; Gamma-aminobutyric acid receptor subunit gamma-2 [mammal]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [mammal]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [mammal]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [mammal]:Wild

Target Species (Bioactivity)

mammal

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

cells

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Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

5.2

Deviation

0.200000

Measurement pX

8.28

Concomitants: Compound RN

6182319; 4763661

Concomitants: Compound name

Ro 15-4513; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [mammal];+Gamma-aminobutyric acid receptor subunit gamma-2 [mammal];+Gamma-aminobutyric acid receptor subunit alpha-2 [mammal]

Target Synonyms

gamma-aminobutyric acid receptor subunit beta-3 + gamma-aminobutyric acid receptor subunit gamma-2 + gamma-aminobutyric acid receptor subunit alpha-2

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-2 [mammal]; Gamma-aminobutyric acid receptor subunit beta-3 [mammal]; Gamma-aminobutyric acid receptor subunit gamma-2 [mammal]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [mammal]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [mammal]:Wild + Gamma-aminobutyric acid receptor subunit alpha-2 [mammal]:Wild

Target Species (Bioactivity)

mammal

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

cells

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.5

Deviation

0.200000

Measurement pX

8.6

Concomitants: Compound RN

6182319; 4763661

Concomitants: Compound name

Ro 15-4513; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [mammal];+Gamma-aminobutyric acid receptor subunit gamma-2 [mammal];+Gamma-aminobutyric acid receptor subunit alpha-3 [mammal]

Target Synonyms

gamma-aminobutyric acid receptor subunit beta-3 + gamma-aminobutyric acid receptor subunit gamma-2 + gamma-aminobutyric acid receptor subunit alpha-3

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Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-3 [mammal]; Gamma-aminobutyric acid receptor subunit beta-3 [mammal]; Gamma-aminobutyric acid receptor subunit gamma-2 [mammal]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [mammal]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [mammal]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [mammal]:Wild

Target Species (Bioactivity)

mammal

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

cells

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

4.8

Deviation

1

Measurement pX

8.32

Concomitants: Compound RN

6182319; 4763661

Concomitants: Compound name

Ro 15-4513; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [mammal];+Gamma-aminobutyric acid receptor subunit alpha-5 [mammal];+Gamma-aminobutyric acid receptor subunit gamma-2 [mammal]

Target Synonyms

gamma-aminobutyric acid receptor subunit beta-3 + gamma-aminobutyric acid receptor subunit alpha-5 + gamma-aminobutyric acid receptor subunit gamma-2

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-5 [mammal]; Gamma-aminobutyric acid receptor subunit beta-3 [mammal]; Gamma-aminobutyric acid receptor subunit gamma-2 [mammal]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [mammal]:Wild + Gamma-aminobutyric acid receptor subunit alpha-5 [mammal]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [mammal]:Wild

Target Species (Bioactivity)

mammal

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

cells

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.11

Deviation

0.230000

Measurement pX

8.68

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149 of 976

Concomitants: Compound RN

6182319; 4763661

Concomitants: Compound name

Ro 15-4513; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [mammal];+Gamma-aminobutyric acid receptor subunit alpha-6 [mammal];+Gamma-aminobutyric acid receptor subunit gamma-2 [mammal]

Target Synonyms

gamma-aminobutyric acid receptor subunit beta-3 + gamma-aminobutyric acid receptor subunit alpha-6 + gamma-aminobutyric acid receptor subunit gamma-2

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-6 [mammal]; Gamma-aminobutyric acid receptor subunit beta-3 [mammal]; Gamma-aminobutyric acid receptor subunit gamma-2 [mammal]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [mammal]:Wild + Gamma-aminobutyric acid receptor subunit alpha-6 [mammal]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [mammal]:Wild

Target Species (Bioactivity)

mammal

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

cells

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Qualitative value

>

Quantitative value

10000

Measurement pX

1

Concomitants: Compound RN

6182319; 6182319

Concomitants: Compound name

Ro 15-4513; [3H]-Ro 15-4513

Concomitants: Compound role

NSB; RAD

Bioassay Category

Metabolism/Transport

Bioassay Name

Binding

Biological Species/NCBI ID

human

Population State

Healthy

Organs/Tissues

plasma

Substance RN

702691View in Reaxys

Substance Name

C-4200

Substance Dose

5 µg/mL

Measurement Parameter

fu

Quantitative value

0.166

Deviation

0.0240000

Lucek; Coutinho; Molecular Pharmacology; vol. 12; nb. 4; (1976); p. 612 - 619, View in Reaxys

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Target Name

Nuclear receptor subfamily 1 group I member 3 [human]

Target Synonyms

car; constitutive activator of retinoid response; constitutive active response; constitutive androstane receptor; nr1i3; nuclear receptor subfamily 1 group i member 3; orphan nuclear receptor mb67

Target Uniprot ID

q14994

Target PDB ID

1xv9; 1xvp

Target, Subunit, Species

Nuclear receptor subfamily 1 group I member 3 [human]

Target Mutant/Chimera Details

Nuclear receptor subfamily 1 group I member 3 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Transactivation assay

Cells/Cell Lines

JHH-7 cell line

Substance RN

702691View in Reaxys

Substance Name

19

Substance Dose

10 µM

Measurement Parameter

Fold-increase

Qualitative value

<

Quantitative value

1.5

Target Name

Cytochrome P450 3A [human]

Target Synonyms

cytochrome p450 3a

Target, Subunit, Species

Cytochrome P450 3A [human]

Target Mutant/Chimera Details

Cytochrome P450 3A [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

% Inhibition

Unit

%

Qualitative value

<

Quantitative value

10

Measurement pX

1

Metabolite RN

899031

Metabolite name

1'-Hydroxymidazolam

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Concomitants: Compound RN

625572; 506008; 506008; 77911; 77911

Concomitants: Compound name

Midazolam; DMSO; DMSO; NADPH; NADPH

Concomitants: Compound role

SUB; SLV; SLV; COE; COE

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Enzymology inhibition

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Cytosol

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

60 µM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

51

Measurement pX

4.24

Metabolite RN

18416447

Metabolite name

M28

Concomitants: Compound RN

19279336; 10502086

Concomitants: Compound name

NADPH regenerating System; [14C]-Boceprevir

Concomitants: Compound role

COM; SUB

; (2011); Type: Clinical Pharmacology Biopharmaceutics Review, Lab: NDA202258, Owner: SCHERING, Number: 000, View in Reaxys 153 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : Wistar rat brain sectionsBioassay : number of brain areas from mesencephalon, cerebral cortex, hippocampus, and cerebellum; Tris-HCl, pH 7.4; 4 deg C; incubated for 40 min; characterization of BZ2 carried out directly by co-incubation with 1 μmol/l zolpidem (specifically binds to BZ1) in vitro; autoradiographical saturation kinetic study of overall benzodiazepine (BZ) binding sites as well as of benzodiazepine binding site subtype 1 (BZ1) and subtype 2 (BZ2); <3H>labelled title comp.

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.0800000 nM

Qualitative Results

KD, equilibrium association constant KDs as well as receptor densities Bmax (32-328 fmol/mg protein) for several brain areas presented; statistically significant differences in affinities of BZ2 with respect to BZ and BZ1 binding sites were mainly found in cortical 1.1 - 4.8 nmol/l

Measurement Parameter

Qualitative

Soria, Carlos; Revilla, Victoria; Candelas, Maria Adoracion; Calvo, Pedro; Fernandez-Lopez, Arsenio; Biochemical Pharmacology; vol. 50; nb. 10; (1995); p. 1619 - 1625, View in Reaxys 154 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

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Bioassay Details

Effect : |receptor; binding activity Target : Trachemys scripta, freshwater turtleBioassay : turtles (0.75-1.3 kg) subjected to a 100 percent N2 atmosphere for up to 24 h; after exposure, cerebral cortex dissected out, and saturation binding assay for GABA/benzodiazepine receptors performed using <3H>labelled title comp.

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

no signif. change in dissociation constant over 24 h of anoxia; signif. increase in receptor density after 12 h of anoxia

Measurement Parameter

Qualitative

Lutz; Leone-Kabler; American Journal of Physiology - Regulatory Integrative and Comparative Physiology; vol. 268; nb. 5 37-5; (1995); p. R1332-R1335, View in Reaxys 155 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : effect on extracellular acidification rateBioassay : 30 min washout to remove GABA, followed by 30 min exposure to title comp.; 15 min washout performed between each GABA concentration; measurement of CGC extracellular acidification rate in cytosensor microphysiometer primary CGC prepared from 8-day-post-natal rats; cells (9-12E5 cells/transwell cup) at 8 days in vitro assessed for response to increasing concentrations of GABA (0.010-1000 μmol/l, 25 deg C, 33 s stimulation) in presence of title comp.

Biological Species/NCBI ID

Rattus norvegicus

Cells/Cell Lines

granule cell

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

100 nM

Qualitative Results

title comp. significantly potentiated GABA-stimulated increase in the extracellular acidification rate at low GABA concentration (0.010-1 μmol/l); graphical representation; title comp. had no effect in the absence of GABA

Measurement Parameter

Qualitative

Brown, Maria J.; Wood, Martyn D.; Coldwell, Martyn C.; Bristow, David R.; British Journal of Pharmacology; vol. 121; nb. 1; (1997); p. 71 - 76, View in Reaxys 156 of 976

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Effect : |drug interaction Bioassay : opioids: morphine sulfate, buprenorphine hydrochloride, methadone hydrochloride; MLD: median lethal dose randomized blind MLD studies; up-and-down method performed in quadruplicate; four series; rats pretreated with title comp., 30 min thereafter treated with opioids; animals examined repeatedly during first 4 h after injection, then daily for mortality

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

40 mg/kg

Substance Route of Adm.

intraperitoneal administration

Qualitative Results

MLDs decreased signif. by pretreatm. with title comp. in case of buprenorphine and methadone; no signif. effects on MLD of morphine; admin. of title comp. signif. prolonged time to death in buprenorphine-treated rats; no signif. effects in other cases

Measurement Parameter

Qualitative

Borron; Monier; Risede; Baud; Human and Experimental Toxicology; vol. 21; nb. 11; (2002); p. 599 - 605, View in Reaxys 157 of 976

Substance Effect

Hypnogenic

Bioassay Category

In Vivo (Animal models)

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Bioassay Name

In vivo Measurement

Bioassay Details

Bioassay : polysomnographic recordings were made at selected nights (1, 2, 3, 4, 7, 10, 12, 14); delta as 0.3-3.0 Hz sigma as 10.0-15.0 Hz and beta as 20.0-28.0 Hz were defined five healthy young volunteers (age 19-22); experiment performed on a fourteen day schedule in a double blind design; from the fourth to the tenth night title comp. administered before bedtime; otherwise placebo was administered at that time

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Route of Adm.

oral administration

Qualitative Results

alteration of delta, sigma and beta EEG induced by title comp. for 7 consecutive nights; sleep EEG subjected to fast Fourier transform analysis; sigma was enhanced without regard to delta amount, but beta only during epochs contng. low delta

Measurement Parameter

Qualitative

Uchida, Sunao; Okudaira, Nobuyuki; Nishihara, Kyoko; Iguchi, Yoshinobu; Tan, Xin; Life Sciences; vol. 59; nb. 9; (1996); p. PL117-PL120, View in Reaxys 158 of 976

159 of 976

Target Name

enzyme

Target Synonyms

enzyme

Target, Subunit, Species

enzyme

Target Mutant/Chimera Details

enzyme:Wild

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |enzyme; inhib. of Bioassay : S-tetralol: S-(+)-1,2,3,4-tetrahydronaphth-1-ol enzyme incubated with title comp. in 0.1 mol/l potassium phosphate buffer (pH 7.4) containing 0.25 mmol/l NADP(1+) and 1.0 mmol/l S-tetralol; dehydrogenase activity determined

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

IC50

Unit

µM

Quantitative value

32

Measurement pX

4.49

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : binding affinity; inhibition ofTarget : rat brain cortex membranesBioassay : ref.: rolipram (IC50: 0.058 μmol/l) membranes treated with <3H>-rolipram; title comp. added; displacement of <3H>-rolipram by title comp. determined by binding assay

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

10 µM

Qualitative Results

percent inhibition of binding affinity by title comp. was 14.7 percent; table

Measurement Parameter

Qualitative

Collado, M. Carmen; Beleta, Jorge; Martinez, Ester; Miralpeix, Montse; Domenech, Teresa; Palacios, Jose Maria; Hernandez, Jesus; British Journal of Pharmacology; vol. 123; nb. 6; (1998); p. 1047 - 1054, View in Reaxys 160 of 976

Target Name

cGMP-specific 3',5'-cGMP phosphodiesterase 3

Target Synonyms

cgmp-specific 3',5'-cgmp phosphodiesterase 3; ddpde3; pde3; phosphodiesterase 3

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Target, Subunit, Species

cGMP-specific 3',5'-cGMP phosphodiesterase 3

Target Mutant/Chimera Details

cGMP-specific 3',5'-cGMP phosphodiesterase 3:Wild

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |enzyme; inhib. of Bioassay : control: vehicle; ref.: rolipram (IC50: 242 μmol/l) enzyme treated with title comp.; cyclic nucleotide phosphodiesterase activities measured by phosphodiesterase assay

Biological Species/NCBI ID

guinea pig

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

200 µM

Qualitative Results

percent inhibition of enzyme by title comp. was 35 percent; table

Measurement Parameter

Qualitative

Collado, M. Carmen; Beleta, Jorge; Martinez, Ester; Miralpeix, Montse; Domenech, Teresa; Palacios, Jose Maria; Hernandez, Jesus; British Journal of Pharmacology; vol. 123; nb. 6; (1998); p. 1047 - 1054, View in Reaxys 161 of 976

Target Name

cAMP-specific 3',5'-cAMP phosphodiesterase 4

Target Synonyms

camp-specific 3',5'-camp phosphodiesterase 4; ddpde4; pde4; phosphodiesterase 4

Target, Subunit, Species

cAMP-specific 3',5'-cAMP phosphodiesterase 4

Target Mutant/Chimera Details

cAMP-specific 3',5'-cAMP phosphodiesterase 4:Wild

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |enzyme; inhib. of Bioassay : control: vehicle; ref.: rolipram (IC50: 0.32 μmol/l) enzyme treated with title comp.; cyclic nucleotide phosphodiesterase activities measured by phosphodiesterase assay

Biological Species/NCBI ID

guinea pig

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

200 µM

Measurement Parameter

IC50

Unit

µM

Quantitative value

64

Measurement pX

4.19

Collado, M. Carmen; Beleta, Jorge; Martinez, Ester; Miralpeix, Montse; Domenech, Teresa; Palacios, Jose Maria; Hernandez, Jesus; British Journal of Pharmacology; vol. 123; nb. 6; (1998); p. 1047 - 1054, View in Reaxys 162 of 976

Target Name

cGMP-specific 3',5'-cyclic phosphodiesterase

Target Synonyms

cgb-pde; cgmp-binding cgmp-specific phosphodiesterase; cgmp-specific 3',5'-cyclic phosphodiesterase; dmpde5/6; dmpde6; pde5; pde5a; pde6

Target, Subunit, Species

cGMP-specific 3',5'-cyclic phosphodiesterase

Target Mutant/Chimera Details

cGMP-specific 3',5'-cyclic phosphodiesterase:Wild

Target Transfection

Non Transfected

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Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |enzyme; inhib. of Bioassay : control: vehicle; ref.: rolipram (IC50: 125 μmol/l) enzyme treated with title comp.; cyclic nucleotide phosphodiesterase activities measured by phosphodiesterase assay

Biological Species/NCBI ID

dog

Cells/Cell Lines

thrombocyte

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

200 µM

Measurement Parameter

IC50

Unit

µM

Quantitative value

66

Measurement pX

4.18

Collado, M. Carmen; Beleta, Jorge; Martinez, Ester; Miralpeix, Montse; Domenech, Teresa; Palacios, Jose Maria; Hernandez, Jesus; British Journal of Pharmacology; vol. 123; nb. 6; (1998); p. 1047 - 1054, View in Reaxys 163 of 976

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Effect : respiration; inhibition ofBioassay : BUP: buprenorphine catheters placed to anesthetized rats 22 h before test; title comp. admin. alone or in combination with 30 mg/kg of BUP; arterial blood samples collected before and at 1.5-120 min after title comp. admin.; blood gases measured

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

30 mg/kg

Substance Route of Adm.

intravenous administration

Qualitative Results

title comp. with BUP caused respiratory depression; no effect on respiration of title comp. alone; decrease in arterial PaO2, blood pH and increase in PaCO2 after dose of title comp. and BUP; conc. of PaO2, PaCO2, HCO3 and pH values vs time; figures

Measurement Parameter

Qualitative

Megarbane, Bruno; Pirnay, Stephane; Borron, Stephen W.; Trout, Herve; Monier, Claire; Risede, Patricia; Boschi, Gabrielle; Baud, Frederic J.; Toxicology Letters; vol. 157; nb. 3; (2005); p. 211 - 219, View in Reaxys 164 of 976

Target Name

Cytochrome P450 [human]

Target Synonyms

cyp1a2; cyp1b1; cyp2a6v2; cyp2b6; cyp2c19; cyp2j2; cyp3a4; cyp3a43; cyp3a43/cyp3a4; cyp4f2; cytochrome p450

Target Uniprot ID

a0n0x8; a4f4k4; c1kde6; c1kde7; c1kde8; d0ezn6; d0ezn7; d0ezn8; e7emt5; o95743; q0vhd5; q13120; q53g23; q5j9b1; q6nwu3; q767a3; q7z2g5; q7z446; q7z447; q7z448; q86sk2; q86sk3; q96rx4; q9unx8

Target, Subunit, Species

Cytochrome P450 [human]

Target Mutant/Chimera Details

Cytochrome P450 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

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165 of 976

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Cytosol

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

100 µM

Measurement Parameter

% Inhibition

Unit

%

Qualitative value

<

Quantitative value

20

Measurement pX

1

Metabolite RN

3596645

Metabolite name

6-beta-naltrexol

Concomitants: Compound RN

3580333; 3580333; 77911

Concomitants: Compound name

Naltrexone hydrochloride; Naltrexone hydrochloride; NADPH

Concomitants: Compound role

SUB; SUB; COE

Target Name

Cytochrome P450 2A6 [human]

Target Synonyms

1,4-cineole 2-exo-monooxygenase; coumarin 7-hydroxylase; cyp2a3; cyp2a6; cypiia6; cytochrome p450 2a6; cytochrome p450 iia3; cytochrome p450(i)

Target Uniprot ID

p11509

Target PDB ID

1z10; 1z11; 2fdu; 2fdv; 2fdw; 2fdy; 3ebs; 3t3q; 3t3r; 4ejj; 4rui

Target, Subunit, Species

Cytochrome P450 2A6 [human]

Target Mutant/Chimera Details

Cytochrome P450 2A6 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

AHH-1 TK+/- cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Km

Unit

µM

Quantitative value

1920.5

Measurement pX

2.72

Metabolite RN

688458; 713494

Metabolite name

desmethylflunitrazepam; 3-hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

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166 of 976

167 of 976

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 2A6 [human]

Target Synonyms

1,4-cineole 2-exo-monooxygenase; coumarin 7-hydroxylase; cyp2a3; cyp2a6; cypiia6; cytochrome p450 2a6; cytochrome p450 iia3; cytochrome p450(i)

Target Uniprot ID

p11509

Target PDB ID

1z10; 1z11; 2fdu; 2fdv; 2fdw; 2fdy; 3ebs; 3t3q; 3t3r; 4ejj; 4rui

Target, Subunit, Species

Cytochrome P450 2A6 [human]

Target Mutant/Chimera Details

Cytochrome P450 2A6 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

AHH-1 TK+/- cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Km

Unit

µM

Quantitative value

297.5

Measurement pX

3.53

Metabolite RN

688458; 713494

Metabolite name

desmethylflunitrazepam; 3-hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 2A6 [human]

Target Synonyms

1,4-cineole 2-exo-monooxygenase; coumarin 7-hydroxylase; cyp2a3; cyp2a6; cypiia6; cytochrome p450 2a6; cytochrome p450 iia3; cytochrome p450(i)

Target Uniprot ID

p11509

Target PDB ID

1z10; 1z11; 2fdu; 2fdv; 2fdw; 2fdy; 3ebs; 3t3q; 3t3r; 4ejj; 4rui

Target, Subunit, Species

Cytochrome P450 2A6 [human]

Target Mutant/Chimera Details

Cytochrome P450 2A6 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

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168 of 976

169 of 976

Cells/Cell Lines

AHH-1 TK+/- cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Vmax

Unit

pmol/min/pmol target

Quantitative value

0.13

Metabolite RN

688458; 713494

Metabolite name

desmethylflunitrazepam; 3-hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 2A6 [human]

Target Synonyms

1,4-cineole 2-exo-monooxygenase; coumarin 7-hydroxylase; cyp2a3; cyp2a6; cypiia6; cytochrome p450 2a6; cytochrome p450 iia3; cytochrome p450(i)

Target Uniprot ID

p11509

Target PDB ID

1z10; 1z11; 2fdu; 2fdv; 2fdw; 2fdy; 3ebs; 3t3q; 3t3r; 4ejj; 4rui

Target, Subunit, Species

Cytochrome P450 2A6 [human]

Target Mutant/Chimera Details

Cytochrome P450 2A6 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

AHH-1 TK+/- cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Vmax

Unit

pmol/min/pmol target

Quantitative value

1

Metabolite RN

688458; 713494

Metabolite name

desmethylflunitrazepam; 3-hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 2A6 [human]

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170 of 976

Target Synonyms

1,4-cineole 2-exo-monooxygenase; coumarin 7-hydroxylase; cyp2a3; cyp2a6; cypiia6; cytochrome p450 2a6; cytochrome p450 iia3; cytochrome p450(i)

Target Uniprot ID

p11509

Target PDB ID

1z10; 1z11; 2fdu; 2fdv; 2fdw; 2fdy; 3ebs; 3t3q; 3t3r; 4ejj; 4rui

Target, Subunit, Species

Cytochrome P450 2A6 [human]

Target Mutant/Chimera Details

Cytochrome P450 2A6 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

AHH-1 TK+/- cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Clint

Unit

nL/min/pmol target

Quantitative value

0.44

Metabolite RN

688458; 713494

Metabolite name

desmethylflunitrazepam; 3-hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 2A6 [human]

Target Synonyms

1,4-cineole 2-exo-monooxygenase; coumarin 7-hydroxylase; cyp2a3; cyp2a6; cypiia6; cytochrome p450 2a6; cytochrome p450 iia3; cytochrome p450(i)

Target Uniprot ID

p11509

Target PDB ID

1z10; 1z11; 2fdu; 2fdv; 2fdw; 2fdy; 3ebs; 3t3q; 3t3r; 4ejj; 4rui

Target, Subunit, Species

Cytochrome P450 2A6 [human]

Target Mutant/Chimera Details

Cytochrome P450 2A6 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

AHH-1 TK+/- cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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171 of 976

172 of 976

Measurement Parameter

Clint

Unit

nL/min/pmol target

Quantitative value

0.52

Metabolite RN

688458; 713494

Metabolite name

desmethylflunitrazepam; 3-hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

AHH-1 TK+/- cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Km

Unit

µM

Quantitative value

154.6

Measurement pX

3.81

Metabolite RN

688458; 713494

Metabolite name

desmethylflunitrazepam; 3-hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450

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3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

173 of 976

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

AHH-1 TK+/- cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Km

Unit

µM

Quantitative value

285.7

Measurement pX

3.54

Metabolite RN

688458; 713494

Metabolite name

desmethylflunitrazepam; 3-hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

AHH-1 TK+/- cell line

Cell Fraction

Microsome

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174 of 976

175 of 976

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Vmax

Unit

pmol/min/pmol target

Quantitative value

1.54

Metabolite RN

688458; 713494

Metabolite name

desmethylflunitrazepam; 3-hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

AHH-1 TK+/- cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Vmax

Unit

pmol/min/pmol target

Quantitative value

15.7

Metabolite RN

688458; 713494

Metabolite name

desmethylflunitrazepam; 3-hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 3A4 [human]

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Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

AHH-1 TK+/- cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Clint

Unit

nL/min/pmol target

Quantitative value

54.95

Metabolite RN

688458; 713494

Metabolite name

desmethylflunitrazepam; 3-hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

AHH-1 TK+/- cell line

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178 of 976

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Clint

Unit

nL/min/pmol target

Quantitative value

9.96

Metabolite RN

688458; 713494

Metabolite name

desmethylflunitrazepam; 3-hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 2B6 [human]

Target Synonyms

1,4-cineole 2-exo-monooxygenase; cyp2b6; cypiib6; cytochrome p450 2b6; cytochrome p450 iib1

Target Uniprot ID

p20813

Target PDB ID

3ibd; 3qoa; 3qu8; 3ua5; 4i91; 4rql; 4rrt; 4zv8; 5uap; 5uda; 5uec; 5ufg

Target, Subunit, Species

Cytochrome P450 2B6 [human]

Target Mutant/Chimera Details

Cytochrome P450 2B6 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

AHH-1 TK+/- cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Km

Unit

µM

Quantitative value

100.7

Measurement pX

4

Metabolite RN

688458

Metabolite name

desmethylflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 2B6 [human]

Target Synonyms

1,4-cineole 2-exo-monooxygenase; cyp2b6; cypiib6; cytochrome p450 2b6; cytochrome p450 iib1

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Target Uniprot ID

p20813

Target PDB ID

3ibd; 3qoa; 3qu8; 3ua5; 4i91; 4rql; 4rrt; 4zv8; 5uap; 5uda; 5uec; 5ufg

Target, Subunit, Species

Cytochrome P450 2B6 [human]

Target Mutant/Chimera Details

Cytochrome P450 2B6 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

AHH-1 TK+/- cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Vmax

Unit

pmol/min/pmol target

Quantitative value

0.27

Metabolite RN

688458

Metabolite name

desmethylflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 2B6 [human]

Target Synonyms

1,4-cineole 2-exo-monooxygenase; cyp2b6; cypiib6; cytochrome p450 2b6; cytochrome p450 iib1

Target Uniprot ID

p20813

Target PDB ID

3ibd; 3qoa; 3qu8; 3ua5; 4i91; 4rql; 4rrt; 4zv8; 5uap; 5uda; 5uec; 5ufg

Target, Subunit, Species

Cytochrome P450 2B6 [human]

Target Mutant/Chimera Details

Cytochrome P450 2B6 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

AHH-1 TK+/- cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Clint

Unit

nL/min/pmol target

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181 of 976

Quantitative value

2.68

Metabolite RN

688458

Metabolite name

desmethylflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 2C19 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase

Target Uniprot ID

p33261

Target PDB ID

4gqs

Target, Subunit, Species

Cytochrome P450 2C19 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Km

Unit

µM

Quantitative value

59.6

Measurement pX

4.22

Metabolite RN

688458

Metabolite name

desmethylflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 2C19 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase

Target Uniprot ID

p33261

Target PDB ID

4gqs

Target, Subunit, Species

Cytochrome P450 2C19 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild

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Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Vmax

Unit

pmol/min/pmol target

Quantitative value

0.83

Metabolite RN

688458

Metabolite name

desmethylflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 2C19 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase

Target Uniprot ID

p33261

Target PDB ID

4gqs

Target, Subunit, Species

Cytochrome P450 2C19 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Clint

Unit

nL/min/pmol target

Quantitative value

13.93

Metabolite RN

688458

Metabolite name

desmethylflunitrazepam

Concomitants: Compound RN

1727945; 3885115

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Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 2C9 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cholesterol 25-hydroxylase; cyp2c10; cyp2c9; cypiic9; cytochrome p-450mp; cytochrome p450 2c9; cytochrome p450 mp-4; cytochrome p450 mp-8; cytochrome p450 pb-1; s-mephenytoin 4-hydroxylase

Target Uniprot ID

p11712

Target PDB ID

1og2; 1og5; 1r9o; 4nz2; 5a5i; 5a5j

Target, Subunit, Species

Cytochrome P450 2C9 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C9 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

AHH-1 TK+/- cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Km

Unit

µM

Quantitative value

50.2

Measurement pX

4.3

Metabolite RN

688458

Metabolite name

desmethylflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 2C9 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cholesterol 25-hydroxylase; cyp2c10; cyp2c9; cypiic9; cytochrome p-450mp; cytochrome p450 2c9; cytochrome p450 mp-4; cytochrome p450 mp-8; cytochrome p450 pb-1; s-mephenytoin 4-hydroxylase

Target Uniprot ID

p11712

Target PDB ID

1og2; 1og5; 1r9o; 4nz2; 5a5i; 5a5j

Target, Subunit, Species

Cytochrome P450 2C9 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C9 [human]:Wild

Target Species (Bioactivity)

human

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Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

AHH-1 TK+/- cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Vmax

Unit

pmol/min/pmol target

Quantitative value

0.38

Metabolite RN

688458

Metabolite name

desmethylflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 2C9 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cholesterol 25-hydroxylase; cyp2c10; cyp2c9; cypiic9; cytochrome p-450mp; cytochrome p450 2c9; cytochrome p450 mp-4; cytochrome p450 mp-8; cytochrome p450 pb-1; s-mephenytoin 4-hydroxylase

Target Uniprot ID

p11712

Target PDB ID

1og2; 1og5; 1r9o; 4nz2; 5a5i; 5a5j

Target, Subunit, Species

Cytochrome P450 2C9 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C9 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

AHH-1 TK+/- cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Clint

Unit

nL/min/pmol target

Quantitative value

7.57

Metabolite RN

688458

Metabolite name

desmethylflunitrazepam

Concomitants: Compound RN

1727945; 3885115

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187 of 976

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Km

Unit

µM

Quantitative value

256.8

Deviation

13.9000

Measurement pX

3.59

Metabolite RN

688458; 713494

Metabolite name

desmethylflunitrazepam; 3-hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

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Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Km

Unit

µM

Quantitative value

207.6

Deviation

31

Measurement pX

3.68

Metabolite RN

688458; 713494

Metabolite name

desmethylflunitrazepam; 3-hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

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Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Vmax

Unit

pmol/min/mg protein

Quantitative value

3671.9

Deviation

1494

Metabolite RN

688458; 713494

Metabolite name

desmethylflunitrazepam; 3-hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Vmax

Unit

pmol/min/mg protein

Quantitative value

478.9

Deviation

150.400

Metabolite RN

688458; 713494

Metabolite name

desmethylflunitrazepam; 3-hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

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Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Clint

Unit

µL/min/mg protein

Quantitative value

2.56

Deviation

0.980000

Metabolite RN

688458; 713494

Metabolite name

desmethylflunitrazepam; 3-hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

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Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

Clint

Unit

µL/min/mg protein

Quantitative value

13.69

Deviation

5.09000

Metabolite RN

688458; 713494

Metabolite name

desmethylflunitrazepam; 3-hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

AHH-1 TK+/- cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

nH

Quantitative value

1.4

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Metabolite RN

688458

Metabolite name

desmethylflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 2C9 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cholesterol 25-hydroxylase; cyp2c10; cyp2c9; cypiic9; cytochrome p-450mp; cytochrome p450 2c9; cytochrome p450 mp-4; cytochrome p450 mp-8; cytochrome p450 pb-1; s-mephenytoin 4-hydroxylase

Target Uniprot ID

p11712

Target PDB ID

1og2; 1og5; 1r9o; 4nz2; 5a5i; 5a5j

Target, Subunit, Species

Cytochrome P450 2C9 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C9 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

AHH-1 TK+/- cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

nH

Quantitative value

2.7

Metabolite RN

688458

Metabolite name

desmethylflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

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Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

nH

Quantitative value

1.2

Deviation

0.0300000

Metabolite RN

688458; 713494

Metabolite name

desmethylflunitrazepam; 3-hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0 µM

Measurement Parameter

nH

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Quantitative value

1.7

Deviation

0.120000

Metabolite RN

688458; 713494

Metabolite name

desmethylflunitrazepam; 3-hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

taurine cattle

Organs/Tissues

retina

Cell Fraction

Homogenate

Substance RN

702691View in Reaxys

Substance Name

[3H]-flunitrazepam

Measurement Parameter

Bmax

Quantitative value

4

Concomitants: Compound RN

754371

Concomitants: Compound name

Diazepam

Concomitants: Compound role

NSB

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

taurine cattle

Organs/Tissues

retina

Cell Fraction

Nucleus and cell debris (P1 fraction)

Substance RN

702691View in Reaxys

Substance Name

[3H]-flunitrazepam

Measurement Parameter

Bmax

Quantitative value

4

Concomitants: Compound RN

754371

Concomitants: Compound name

Diazepam

Concomitants: Compound role

NSB

Substance Action on Target

Radioligand (/ligand)

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200 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

taurine cattle

Organs/Tissues

retina

Cell Fraction

Synaptosome (P2 fraction)

Substance RN

702691View in Reaxys

Substance Name

[3H]-flunitrazepam

Measurement Parameter

Bmax

Unit

pmol/mg

Quantitative value

0.08

Deviation

0.00200000

Concomitants: Compound RN

754371

Concomitants: Compound name

Diazepam

Concomitants: Compound role

NSB

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

taurine cattle

Organs/Tissues

retina

Cell Fraction

Synaptosome (P2 fraction)

Substance RN

702691View in Reaxys

Substance Name

[3H]-flunitrazepam

Measurement Parameter

Bmax

Unit

pmol/mg

Quantitative value

0.103

Deviation

0.00200000

Concomitants: Compound RN

754371

Concomitants: Compound name

Diazepam

Concomitants: Compound role

NSB

Target Name

Histamine H1 receptor [Rattus norvegicus]

Target Synonyms

h1r; hh1r; histamine h1 receptor; hrh1

Target Uniprot ID

p31390

Target, Subunit, Species

Histamine H1 receptor [Rattus norvegicus]

Target Mutant/Chimera Details

Histamine H1 receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

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202 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Sprague Dawley rat

Organs/Tissues

brain

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

17000

Measurement pX

4.77

Concomitants: Compound RN

435610; 87215

Concomitants: Compound name

[3H]-Pyrilamine; Triprolidine

Concomitants: Compound role

RAD; NSB

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Wistar rat

Organs/Tissues

forebrain

Cell Fraction

P2 fraction: membrane

Substance RN

702691View in Reaxys

Substance Name

RO 5-4200 (flunitrazepam)

Measurement Parameter

IC50

Unit

nM

Quantitative value

5

Measurement pX

8.3

Concomitants: Compound RN

754371; 754371

Concomitants: Compound name

Diazepam; [3H]-Diazepam

Concomitants: Compound role

NSB; RAD

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

taurine cattle

Organs/Tissues

retina

Cell Fraction

Homogenate

Substance RN

702691View in Reaxys

Substance Name

[3H]-flunitrazepam

Measurement Parameter

Bmax

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Unit

pmol/mg

Quantitative value

0.085

Deviation

0.0130000

Concomitants: Compound RN

754371

Concomitants: Compound name

Diazepam

Concomitants: Compound role

NSB

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

taurine cattle

Organs/Tissues

retina

Cell Fraction

Nucleus and cell debris (P1 fraction)

Substance RN

702691View in Reaxys

Substance Name

[3H]-flunitrazepam

Measurement Parameter

Bmax

Unit

pmol/mg

Quantitative value

0.015

Deviation

0.00200000

Concomitants: Compound RN

754371

Concomitants: Compound name

Diazepam

Concomitants: Compound role

NSB

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit beta-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18507 + p47870 + p14867

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

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Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

3.9

Deviation

0.900000

Measurement pX

8.41

Concomitants: Compound RN

702691; 4763661

Concomitants: Compound name

Flunitrazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-2 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-2; gabra2; gamma-aminobutyric acid receptor subunit alpha-2

Target Uniprot ID

p28472 + p18507 + p47869

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-2 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-2 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

1.1

Deviation

0.500000

Measurement pX

8.96

Concomitants: Compound RN

702691; 4763661

Concomitants: Compound name

Flunitrazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-3 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

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Target Uniprot ID

p28472 + p18507 + p34903

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-3 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

5.9

Deviation

1.50000

Measurement pX

8.23

Concomitants: Compound RN

702691; 4763661

Concomitants: Compound name

Flunitrazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2;+Gamma-aminobutyric acid receptor subunit beta-2;+Gamma-aminobutyric acid receptor subunit alpha-1

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1; Gamma-aminobutyric acid receptor subunit beta-2; Gamma-aminobutyric acid receptor subunit gamma-2

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2:Wild + Gamma-aminobutyric acid receptor subunit beta-2:Wild + Gamma-aminobutyric acid receptor subunit alpha-1:Wild

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

% Stimulation

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Unit

%

Quantitative value

121

Deviation

9

Measurement pX

7.28

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : brain membranes from bovine brainBioassay : membranes prepared from cerebral cortex or cerebellum by known method; radioligand labelling; binding place determined after hydroxylamine cleavage

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

photoaffinity labelling in receptor population occurs within residues 1-103 of the α1 sequence

Measurement Parameter

Qualitative

Duncalfe; Dunn; European Journal of Pharmacology; vol. 298; nb. 3; (1996); p. 313 - 319, View in Reaxys 209 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : cerebral cortical neurones from 15-d-old fetus of ddY mouseBioassay : neurones cultured with 1 μM α-CCE at 37 deg C for 12 h or not (control); the extensively washed membrane fractions from neurones then incubated with various concns. of (3H)title comp. at 2 deg C for 60 min; Scatchard analysis neopallium free of meninges dissected from a 15-day-old fetus, minced, trypsinized and centrifuged, cultured at 37 deg C for 3 ds; <95 percent of the cells confirmed to be neurons by immunohistochemical approch

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.0310000 nM

Qualitative Results

high affinity binding site for (3H)-title comp. Bmax 1.51 pmol/mg protein (absence of α-CCE); Bmax 1.06 pmol/mg protein (presence of α-CCE) decrease after 3 h exposure to α-CCE; Kd 12.0 nM (control) 11.2

Measurement Parameter

Qualitative

Katsura, Masashi; Ohkuma, Seitaro; Jun, Xu; Kuriyama, Kinya; European Journal of Pharmacology; vol. 298; nb. 1; (1996); p. 71 - 77, View in Reaxys 210 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : cerebral cortical neurones from 15-d-old fetus of ddY mouseBioassay : neurones cultured with 1 μM α-CCE at 37 deg C for 12 h, or not (control); the extensively washed membrane fractions from neurones then incubated with 1 nM (3H)-title comp. at 2 deg C for 60 min in presence of various concns. of non labeled title comp. neopallium free of meninges dissected from a 15-day-old fetus, minced, trypsinized and centrifuged, cultured at 37 deg C for 3 ds; <95 percent of the cells confirmed to be neurons by immunohistochemical approch

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.100000 µM

Measurement Parameter

IC50

Unit

nM

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Quantitative value

2.8

Measurement pX

8.55

Katsura, Masashi; Ohkuma, Seitaro; Jun, Xu; Kuriyama, Kinya; European Journal of Pharmacology; vol. 298; nb. 1; (1996); p. 71 - 77, View in Reaxys 211 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : modulation of GABA currentsTarget : Xenopus laevis oocytes injected with α1α1α2sBioassay : adult Xenopus laevis stage V and VI oocytes nuclei inj. with recombinant human GABAA receptors; title compound effect examined using two-electrode voltage-clamp method; on control GABA EC20 responses with a preapplication time of 30 sec

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1 µM

Qualitative Results

ca. 125 percent modulation of control GABA EC20 (fig. given)

Measurement Parameter

Qualitative

Wafford; Thompson; Thomas; Sikela; Wilcox; Whiting; Molecular Pharmacology; vol. 50; nb. 3; (1996); p. 670 - 678, View in Reaxys 212 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : modulation of GABA currentsTarget : Xenopus laevis oocytes injected with α4α1α2sBioassay : adult Xenopus laevis stage V and VI oocytes nuclei inj. with recombinant human GABAA receptors; title compound effect examined using two-electrode voltage-clamp method; on control GABA EC20 responses with a preapplication time of 30 sec

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1 µM

Measurement Parameter

Qualitative

Qualitative value

NA

Measurement pX

1

Wafford; Thompson; Thomas; Sikela; Wilcox; Whiting; Molecular Pharmacology; vol. 50; nb. 3; (1996); p. 670 - 678, View in Reaxys 213 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : modulation of GABA currentsTarget : Xenopus laevis oocytes injected with α6α1α2sBioassay : adult Xenopus laevis stage V and VI oocytes nuclei inj. with recombinant human GABAA receptors; title compound effect examined using two-electrode voltage-clamp method; on control GABA EC20 responses with a preapplication time of 30 sec

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1 µM

Measurement Parameter

Qualitative

Qualitative value

NA

Measurement pX

1

Wafford; Thompson; Thomas; Sikela; Wilcox; Whiting; Molecular Pharmacology; vol. 50; nb. 3; (1996); p. 670 - 678, View in Reaxys 214 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

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Bioassay Details

Effect : |metabolic Target : Harlan Spraque-Dawley ratBioassay : coronal sections of the freezed brain, thickness 12 μ; incubation with 1nM 3H radiolabelled flunitrazepam for various time and temperatures (4 and 22 Celsius degrees); the sections were then exposed for 2 weeks

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

incubation 90 min in -4 Celsius degrees: the best results; in pentobarbital-tolerant rats: the activity observed in most regions of the brain; in pentobarbital-dependent rats: the binding sites increased in relatively large number of brain regions

Measurement Parameter

Qualitative

Suzuki, Toshihito; Ito, Takehiko; Wellman, Susan E.; Ho, Ing Kang; European Journal of Pharmacology; vol. 295; nb. 2-3; (1996); p. 169 - 179, View in Reaxys 215 of 976

216 of 976

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p28472 + p18507 + p14867

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam 68

Substance Dose

1.00000E-09 M

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.2

Measurement pX

8.66

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-2 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-2; gabra2; gamma-aminobutyric acid receptor subunit alpha-2

Target Uniprot ID

p28472 + p18507 + p47869

Target PDB ID

4cof

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217 of 976

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-2 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-2 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam 68

Substance Dose

1.00000E-09 M

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.5

Measurement pX

8.6

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-3 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p28472 + p18507 + p34903

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-3 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam 68

Substance Dose

1.00000E-09 M

Measurement Parameter

Ki

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218 of 976

219 of 976

Unit

nM

Quantitative value

4.5

Measurement pX

8.35

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit alpha-5 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2

Target Uniprot ID

p28472 + p31644 + p18507

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-5 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-5 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam 68

Substance Dose

1.00000E-09 M

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.1

Measurement pX

8.68

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit alpha-6 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-6; gabra6; gamma-aminobutyric acid receptor subunit alpha-6 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2

Target Uniprot ID

p28472 + q16445 + p18507

Target PDB ID

4cof

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220 of 976

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-6 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-6 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam 68

Substance Dose

1.00000E-09 M

Measurement Parameter

Ki

Unit

nM

Qualitative value

>

Quantitative value

2000

Measurement pX

5.7

Concomitants: Compound RN

6182319

Concomitants: Compound name

[3H]-Ro 15-4513

Concomitants: Compound role

RAD

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : cerebellar membranes from Sprague-Dawley ratsBioassay : membrane homogenates of cerebellum from rats prepared according to Endo and Olsen (J.Neurochem. 59,1444 (1993)); supernatant or pellet suspension incubated with ligand; radioligand assay

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

binding activities of immunoprecipitates in Fig.

Measurement Parameter

Qualitative

Huh, Kyung-Hye; Endo, Shuichi; Olsen, Richard W.; European Journal of Pharmacology; vol. 310; nb. 2-3; (1996); p. 225 233, View in Reaxys 221 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Bioassay : in vitro; equilibrium binding assay; <3H>labeled title comp. (spec. act. >80 Ci/mmol); intact cells; Tris-citrate buffer (pH 7.4); 0 deg C; scintillation counting

Biological Species/NCBI ID

Rattus norvegicus

Cells/Cell Lines

granule cell

Substance RN

702691View in Reaxys

Substance Name

31870

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Substance Dose

0.300000 nM

Measurement Parameter

Kd

Unit

nM

Quantitative value

3.28

Measurement pX

8.48

Vale, Carmen; Pomes, Anna; Rodriguez-Farre, Eduard; Sunol, Cristina; European Journal of Pharmacology; vol. 319; nb. 2-3; (1997); p. 343 - 353, View in Reaxys 222 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Bioassay Details

Effect : |receptor; binding activity Bioassay : nonspecific binding detn. in presence of 10 μmol/l of title comp.; Scatchard analysis; filtered; radioactivity counted by liquid scintillation counter synaptic membrane prepn. from bovine brain in Tris-citrate buffer pH 7.1, contg. 0.2-0.3 mg protein incubated with 0.5 nmol/l (3H)title comp. in presence or absence of N3-phenacyluridine at 4 deg C for 1 h

Biological Species/NCBI ID

taurine cattle

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

IC50

Unit

µM

Quantitative value

129

Measurement pX

3.89

Kimura, Toshiyuki; Kuze, Jiro; Watanabe, Kazuhito; Kondo, Shigemi; Ho, Ing Kang; Yamamoto, Ikuo; European Journal of Pharmacology; vol. 311; nb. 2-3; (1996); p. 265 - 269, View in Reaxys 223 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |protein binding Target : polyclonal antibody to benzodiazepinesBioassay : 3H labeled title comp. phosphate buffer, pH 7.4; room temp.; 30 min incubation; quantified by fluorescence correlation microscopy

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

Kd

Unit

nM

Quantitative value

272.7

Measurement pX

6.56

Hegener, Oliver; Jordan, Randolf; Haeberlein, Hanns; Journal of Medicinal Chemistry; vol. 47; nb. 14; (2004); p. 3600 3605, View in Reaxys 224 of 976

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Effect : |drug interaction Bioassay : rats trained for 3 d; 24 h after rats treated with title comp. for 45 min and with gaboxadol (Ca 1-10 mg/kg, s.c.) for 30 min; rotarod motor coordination test performed

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

5 mg/kg

Substance Route of Adm.

intraperitoneal administration

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Qualitative Results

no synergistic interaction between title comp. and gaboxadol observed

Measurement Parameter

Qualitative

Voss, Jeppe; Sanchez, Connie; Michelsen, Signe; Ebert, Bjarke; European Journal of Pharmacology; vol. 482; nb. 1-3; (2003); p. 215 - 222, View in Reaxys 225 of 976

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Effect : |drug interaction Bioassay : 24 h before title comp. administration rats trained for 3 d; treatment with ethanol (1.0 g/kg, i.p.) for 15 min and with title comp. for 45 min; rotarod motor coordination test performed

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.156000 mg/kg

Substance Route of Adm.

intraperitoneal administration

Qualitative Results

supra-additive effect of title comp. at dose of 0.63 mg/kg and ethanol observed

Measurement Parameter

Qualitative

Voss, Jeppe; Sanchez, Connie; Michelsen, Signe; Ebert, Bjarke; European Journal of Pharmacology; vol. 482; nb. 1-3; (2003); p. 215 - 222, View in Reaxys 226 of 976

Substance Effect

Behavioural Symptoms

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Bioassay : 24 h before title comp. administration rats trained for 3 d; treatment with title comp. for 45 min; rotarod motor coordination test performed

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.160000 mg/kg

Substance Route of Adm.

intraperitoneal administration

Measurement Parameter

ED50

Unit

mg/kg

Quantitative value

4.63

Voss, Jeppe; Sanchez, Connie; Michelsen, Signe; Ebert, Bjarke; European Journal of Pharmacology; vol. 482; nb. 1-3; (2003); p. 215 - 222, View in Reaxys 227 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |agonist Target : Xenopus laevis oocyte expressing α1α2α2 GABAA receptorBioassay : oocyte preperfused with title comp. for 3 min before addition of GABA, voltage clamped at -60 mV; Cl(-) current measured

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1.00000E-10 M

Measurement Parameter

EC50

Unit

nM

Quantitative value

5.9

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Measurement pX

8.23

Davies, Martin; Newell, J. Glen; Derry, Jason M. C.; Martin, Ian L.; Dunn, Susan M. J.; Molecular Pharmacology; vol. 58; nb. 4; (2000); p. 756 - 762, View in Reaxys 228 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |agonist Target : Xenopus laevis oocyte expressing α1α2α3 GABAA receptorBioassay : oocyte preperfused with title comp. for 3 min before addition of GABA, voltage clamped at -60 mV; Cl(-) current measured

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1.00000E-10 M

Measurement Parameter

EC50

Unit

nM

Quantitative value

14.8

Measurement pX

7.83

Davies, Martin; Newell, J. Glen; Derry, Jason M. C.; Martin, Ian L.; Dunn, Susan M. J.; Molecular Pharmacology; vol. 58; nb. 4; (2000); p. 756 - 762, View in Reaxys 229 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |agonist Target : Sprague-Dawley rat cortical wedgeBioassay : further study: influence of ethanol and Ro 15-1788 on title comp. effect; GABA: α-aminobutyric acid wedges were superfused for 20 min with superfusion buffer containing title comp.; GABA/gaboxadol EC20 applied with title comp.; number of spikes during last 12 min counted; relative frequency calculated

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1000 nM

Qualitative Results

% potentiation of GABA/gaboxadol EC20 response by title comp. were 18.6/60, resp.; ethanol not potentiated GABA/gaboxadol EC20 response; Ro 15-1788 partially antagonised title comp. effect for GABA, completely abolished for gaboxadol EC20; fig., table

Measurement Parameter

Qualitative

Storustovu, Signe i; Ebert, Bjarke; European Journal of Pharmacology; vol. 467; nb. 1-3; (2003); p. 49 - 56, View in Reaxys 230 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |agonist Target : Xenopus laevis oocytes expressing human GABAA receptorsBioassay : test system comprising GABAA (α-aminobutyric acid type A) receptors are composed of α1α3α2S subunits; further study: influence of ethanol and Ro 15-1788 on title comp. effect oocytes superfused with solution containing title comp.; after 60 s, gaboxadol EC20 and title comp. were co-applied; potentiation of gaboxadol EC20 responses by title comp. was investigated

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

10 nM

Qualitative Results

title comp. potentiated gaboxadol EC20 responses by 124%; ethanol was not able to bring further potentiation for title comp.; Ro 15-1788 increased gaboxadol EC20 response by 10%; fig.

Measurement Parameter

Qualitative

Storustovu, Signe i; Ebert, Bjarke; European Journal of Pharmacology; vol. 467; nb. 1-3; (2003); p. 49 - 56, View in Reaxys 231 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450

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3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

232 of 976

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cells/Cell Lines

liver cell

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

Vmax

Unit

nmol/min/1e6 cells

Quantitative value

0.019

Deviation

0.0150000

Metabolite RN

688458; 713494; 751823; 759300

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cells/Cell Lines

liver cell

Substance RN

702691View in Reaxys

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233 of 976

234 of 976

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

Vmax

Unit

nmol/min/1e6 cells

Quantitative value

0.14

Deviation

0.130000

Metabolite RN

688458; 713494; 751823; 759300

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cells/Cell Lines

liver cell

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

S50

Unit

µM

Quantitative value

66

Deviation

45

Metabolite RN

713494; 759300

Metabolite name

3-Hydroxyflunitrazepam; (+/-)-Temazepam

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

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235 of 976

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cells/Cell Lines

liver cell

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

nH

Quantitative value

2.1

Metabolite RN

713494; 759300

Metabolite name

3-Hydroxyflunitrazepam; (+/-)-Temazepam

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cells/Cell Lines

liver cell

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

Km

Unit

µM

Quantitative value

43

Deviation

17

Measurement pX

4.37

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236 of 976

237 of 976

Metabolite RN

688458; 751823

Metabolite name

Desmethylflunitrazepam; N-Desmethyldiazepam

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cells/Cell Lines

liver cell

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

Clint

Unit

µL/min/1e6 cells

Quantitative value

0.442

Metabolite RN

688458; 751823

Metabolite name

Desmethylflunitrazepam; N-Desmethyldiazepam

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

ligand affinities for calmodulin and tropinon C and effect on calmodulin dependent stimulation of cyclic nucleotide phosphodiesterase

Measurement Parameter

Qualitative

Tkachuk; Baldenkov; Feoktistov; Men'shikov; Quast; Herzig; Arzneimittel-Forschung/Drug Research; vol. 37; nb. 9; (1987); p. 1013 - 1017, View in Reaxys 238 of 976

Substance Effect

Hypnogenic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Bioassay : high intra-individual consistency of relative EEG power patterns on 4DN and 7DN was observed; double blind design 5 healthy volunteers (Ss, 19 - 22 yrs); title comp. administered for seven consecutive nights 30 min before bed time; sleep EEG from baseline night, the initial title comp. night the fourth (4DN) and the seventh (7DN) nights analysed

Biological Species/NCBI ID

human

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Substance RN

702691View in Reaxys

Substance Name

31870

Substance Route of Adm.

oral administration

Qualitative Results

during non rapid eye movement (NREM) sleep of 4DN and 7DN sigma band activity was similarly enhanced in every S; in rapid eye movement sleep of 4DN and 7DN the beta band was enhanced with larger variations among Ss (table, diagram)

Measurement Parameter

Qualitative

Uchida, Sunao; Okudaira, Nobuyuki; Nishihara, Kyoko; Iguchi, Yoshinobu; Life Sciences; vol. 58; nb. 10; (1996); p. PL199-PL205, View in Reaxys 239 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : receptor photoaffinity labelingTarget : R-3327 Dunning prostatic tumorBioassay : tumor sublines AT-1, H, G; mitochondrial and microsomal fractions; peripheral benzodiazepine receptor; <N-methyl-3H>title comp.; preincubation (dark, 15 min); 60 min. UV irradiation; 10 μmol/l of unlabeled title comp.; electrophoresis

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

100 nM

Measurement Parameter

Qualitative

Qualitative value

ND

Alenfall, Jan; Batra, Satish; Biochemical Pharmacology; vol. 51; nb. 8; (1996); p. 1009 - 1013, View in Reaxys 240 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : Guinea pig cortex membraneBioassay : specific <3H>ligand binding to receptors was determined by subtracting the total from the non-specific counts; non-specific ligand: 10 μM diazepam; receptor: benzodiazepine cortex from male animals 200-400 g weight; equilibrium binding assays; 200-400 μg of protein was used; after 0.5-2 h the assays were terminated by collecting the samples on glass-fiber filters with a cell harvester

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

Kd

Unit

nM

Quantitative value

2.1

Measurement pX

8.68

Gordon; Nigam; Weitz; Dave; Doctor; Ved; Journal of applied toxicology : JAT; vol. 21 Suppl 1; (2001); p. S47-51, View in Reaxys 241 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Cmax

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Unit

ng/mL

Quantitative value

6

Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys 242 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Concentration

Unit

ng/mL

Quantitative value

0.4

Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys 243 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Tmax

Unit

hour

Quantitative value

1

Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys 244 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg

Substance Route of Adm.

oral administration

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Substance Dosing Regimen

Single

Measurement Parameter

AUC

Unit

ng.h/mL

Quantitative value

57

Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys 245 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

t1/2 el

Unit

hour

Quantitative value

16

Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys 246 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Cmax

Unit

ng/mL

Quantitative value

6

Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys 247 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

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Substance Dose

1 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Concentration

Unit

ng/mL

Quantitative value

0.4

Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys 248 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Tmax

Unit

hour

Quantitative value

1

Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys 249 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

AUC

Unit

ng.h/mL

Quantitative value

57

Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys 250 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

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Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

t1/2 el

Unit

hour

Quantitative value

16

Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys 251 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

AUC i/AUC

Quantitative value

1.28

Concomitants: Compound RN

75279

Concomitants: Compound name

Erythromycin

Concomitants: Compound role

ICP

Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys 252 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

t1/2 el i/t1/2 el

Quantitative value

1.56

Concomitants: Compound RN

75279

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Concomitants: Compound name

Erythromycin

Concomitants: Compound role

ICP

Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys 253 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Cmax i/Cmax

Quantitative value

1.17

Concomitants: Compound RN

75279

Concomitants: Compound name

Erythromycin

Concomitants: Compound role

ICP

Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys 254 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Concentration i/Concentration

Quantitative value

1.75

Concomitants: Compound RN

75279

Concomitants: Compound name

Erythromycin

Concomitants: Compound role

ICP

Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys

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255 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

AUC i/AUC

Quantitative value

1.25

Concomitants: Compound RN

75279

Concomitants: Compound name

Erythromycin

Concomitants: Compound role

ICP

Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys 256 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

t1/2 el i/t1/2 el

Quantitative value

2

Concomitants: Compound RN

75279

Concomitants: Compound name

Erythromycin

Concomitants: Compound role

ICP

Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys 257 of 976

Target Name

Cholecystokinin receptor [Rattus norvegicus]

Target Synonyms

cholecystokinin receptor

Target, Subunit, Species

Cholecystokinin receptor [Rattus norvegicus]

Target Mutant/Chimera Details

Cholecystokinin receptor [Rattus norvegicus]:Wild

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258 of 976

259 of 976

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

pancreas

Cell Fraction

Homogenate/Centrifugation/Pellet

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

IC50

Unit

µM

Qualitative value

>

Quantitative value

100

Measurement pX

1

Concomitants: Compound RN

1719757

Concomitants: Compound name

Dithiothreitol

Concomitants: Compound role

COM

Target Name

Cholecystokinin receptor [guinea pig]

Target Synonyms

cholecystokinin receptor

Target, Subunit, Species

Cholecystokinin receptor [guinea pig]

Target Mutant/Chimera Details

Cholecystokinin receptor [guinea pig]:Wild

Target Species (Bioactivity)

guinea pig

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

guinea pig

Organs/Tissues

brain

Cell Fraction

Homogenate/Centrifugation/Pellet

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

IC50

Unit

µM

Qualitative value

>

Quantitative value

100

Measurement pX

1

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

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260 of 976

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

brain cortex

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

IC50

Unit

µM

Quantitative value

0.0017

Measurement pX

8.77

Concomitants: Compound RN

754371

Concomitants: Compound name

[3H]-Diazepam

Concomitants: Compound role

RAD

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : GABAA receptors, recombinant, cloned on HEK 293 cellsBioassay : HEK: human embryonic kidney cells transfected with cDNAs for α1-, α3-, α2 subunits of GABAA receptors and their combinations; incubated in Tris-citrate buffer, 90 min, 4 deg C, with <3H>-labeled title comp.; non-specific binding in pres. diazepam; scintillation

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

20 nM

Qualitative Results

high affinity binding only to membranes from cells transfected with α1α2- and α1α3α2-subunits, low affinity binding also to non-transfected cells; diagram

Measurement Parameter

Qualitative

Zezula; Slany; Sieghart; European Journal of Pharmacology; vol. 301; nb. 1-3; (1996); p. 207 - 214, View in Reaxys 261 of 976

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

hippocampus

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

32

Measurement Parameter

IC50

Unit

nM

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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262 of 976

263 of 976

Quantitative value

2.7

Deviation

0.100000

Measurement pX

8.57

Concomitants: Compound RN

754371; 702691

Concomitants: Compound name

Diazepam; [3H]-Flunitrazepam

Concomitants: Compound role

NSB; RAD

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

cerebellum

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

32

Measurement Parameter

IC50

Unit

nM

Quantitative value

2.9

Deviation

0.700000

Measurement pX

8.54

Concomitants: Compound RN

754371; 702691

Concomitants: Compound name

Diazepam; [3H]-Flunitrazepam

Concomitants: Compound role

NSB; RAD

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus; Rattus norvegicus

Organs/Tissues

brain cortex

Cells/Cell Lines

cells

Cell Fraction

Synaptosome

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flunitrazepam

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264 of 976

265 of 976

Measurement Parameter

Bmax

Unit

µmol/mg protein

Quantitative value

765

Deviation

78

Concomitants: Compound RN

205542

Concomitants: Compound name

Melatonin

Concomitants: Compound role

APR

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus; Rattus norvegicus

Organs/Tissues

brain cortex

Cells/Cell Lines

cells

Cell Fraction

Synaptosome

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flunitrazepam

Measurement Parameter

Bmax

Unit

µmol/mg protein

Quantitative value

870

Deviation

22

Concomitants: Compound RN

754371

Concomitants: Compound name

Diazepam

Concomitants: Compound role

APR

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Cmax

Unit

ng/mL

Quantitative value

7

Concomitants: Compound RN

75279

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Concomitants: Compound name

Erythromycin

Concomitants: Compound role

ICP

Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys 266 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Concentration

Unit

ng/mL

Quantitative value

0.7

Concomitants: Compound RN

75279

Concomitants: Compound name

Erythromycin

Concomitants: Compound role

ICP

Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys 267 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Tmax

Unit

hour

Quantitative value

2

Concomitants: Compound RN

75279

Concomitants: Compound name

Erythromycin

Concomitants: Compound role

ICP

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys 268 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

AUC

Unit

ng.h/mL

Quantitative value

73

Statistical sgnificance (pvalue)

0.043

Concomitants: Compound RN

75279

Concomitants: Compound name

Erythromycin

Concomitants: Compound role

ICP

Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys 269 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Non Smoker

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

t1/2 el

Unit

hour

Quantitative value

25

Statistical sgnificance (pvalue)

0.043

Concomitants: Compound RN

75279

Concomitants: Compound name

Erythromycin

Concomitants: Compound role

ICP

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Luurila, Harri; Olkkola, Klaus T.; Neuvonen, Pertti J.; Pharmacology and Toxicology; vol. 78; nb. 2; (1996); p. 117 - 122, View in Reaxys 270 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Bioassay : tissues homogenized, centrifuged twice, incubated in 50 mM Tris HCl, PH 7.7 at 0 deg C with 5 nM <3H>Ro 15-4513 + 65 μM alpidem; radiactivity determined by liquid scintillation

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

Ki

Unit

nM

Quantitative value

15

Measurement pX

7.82

Maguire; Davies; Loew; European Journal of Pharmacology; vol. 280; nb. 2; (1995); p. 167 - 173, View in Reaxys 271 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Bioassay : filtered, filters were subjected to scintillation counting cells were cultured and transfected with cDNA encoding for α1, α3 or α2 subunits of GABAA receptors, membranes extracted, frozen membranes thawed, centrifuged, incubated in buffer with 3H-radiolabeled title comp. at 4 degC for 90 min

Biological Species/NCBI ID

human

Cells/Cell Lines

HEK293-EBNA cell line

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

high affinity binding sites observed in membranes from cells cotransfected with α1, α3, and α2 subunits while no binding sites were formed from cells transfected with these subunits

Measurement Parameter

Qualitative

Slany; Zezula; Tretter; Sieghart; Molecular Pharmacology; vol. 48; nb. 3; (1995); p. 385 - 391, View in Reaxys 272 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Bioassay Details

Effect : |receptor; binding activity Target : Wistar rat cerebral synaptic membranesBioassay : nonspecific binding determined by parallel incubations with 1E-5 M diazepam rat weighing 180-220 g; incubation of membrane preparations with <3H> labelled title comp. together with 1E-9 - 1E-3 M S-adenosyl-L-homocysteine, S-adenosylmethionine and 5'-methylthioadenosine, resp. for 1 h at 4 deg C; liquid scintillation

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

8 nM

Qualitative Results

inhibition of title comp. binding with Ki value of 7.9 μM and 15.8 μM, resp. by S-adenosylhomocysteine and 5'-methylthioadenosine; no effect of S-adenosylmethionine

Measurement Parameter

Qualitative

Tsvetnitsky; Campbell; Gibbons; European Journal of Pharmacology; vol. 282; nb. 1-3; (1995); p. 255 - 258, View in Reaxys 273 of 976

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

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274 of 976

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Sprague Dawley rat

Organs/Tissues

brain

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

IC50

Unit

µM

Quantitative value

0.005

Deviation

0.00150000

Measurement pX

8.3

Concomitants: Compound RN

754371; 754371

Concomitants: Compound name

Diazepam; [3H]-Diazepam

Concomitants: Compound role

NSB; RAD

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Sprague Dawley rat

Organs/Tissues

brain

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

GABA ratio

Measurement Object

IC50

Quantitative value

1.41

Concomitants: Compound RN

754371; 754371; 906818

Concomitants: Compound name

Diazepam; [3H]-Diazepam; GABA

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275 of 976

276 of 976

Concomitants: Compound role

NSB; RAD; AGO

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

brain cortex

Cells/Cell Lines

nerve cell

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

IC50

Unit

nM

Quantitative value

3.8

Measurement pX

8.42

Concomitants: Compound RN

702691; 4763661

Concomitants: Compound name

[3H]-Flunitrazepam; Flumazenil

Concomitants: Compound role

RAD; NSB

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Chbb:THOM rat

Organs/Tissues

brain cortex

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

IC50

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277 of 976

278 of 976

Unit

nM

Quantitative value

3.2

Deviation

1.30000

Measurement pX

8.49

Concomitants: Compound RN

754371; 702691

Concomitants: Compound name

Diazepam; [3H]-Flunitrazepam

Concomitants: Compound role

NSB; RAD

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Chbb:THOM rat

Organs/Tissues

brain cortex

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

IC50

Unit

nM

Quantitative value

5.9

Deviation

0.800000

Measurement pX

8.23

Concomitants: Compound RN

839277

Concomitants: Compound name

[3H]-Brotizolam

Concomitants: Compound role

RAD

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Substance Action on Target

Radioligand (/ligand)

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279 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Chbb:THOM rat

Organs/Tissues

cerebellum

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[H3]-flunitrazepam

Measurement Parameter

Kd

Unit

nM

Quantitative value

1.4

Deviation

0.130000

Measurement pX

8.85

Concomitants: Compound RN

754371

Concomitants: Compound name

Diazepam

Concomitants: Compound role

NSB

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Chbb:THOM rat

Organs/Tissues

cerebellum

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[H3]-flunitrazepam

Measurement Parameter

Bmax

Unit

pmol/g

Quantitative value

57

Deviation

5.40000

Concomitants: Compound RN

754371

Concomitants: Compound name

Diazepam

Concomitants: Compound role

NSB

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280 of 976

281 of 976

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Chbb:THOM rat

Organs/Tissues

hippocampus

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[H3]-flunitrazepam

Measurement Parameter

Kd

Unit

nM

Quantitative value

1.48

Deviation

0.450000

Measurement pX

8.83

Concomitants: Compound RN

754371

Concomitants: Compound name

Diazepam

Concomitants: Compound role

NSB

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Chbb:THOM rat

Organs/Tissues

hippocampus

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[H3]-flunitrazepam

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282 of 976

283 of 976

Measurement Parameter

Bmax

Unit

pmol/g

Quantitative value

55.9

Deviation

22

Concomitants: Compound RN

754371

Concomitants: Compound name

Diazepam

Concomitants: Compound role

NSB

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

CD rat

Organs/Tissues

brain

Cells/Cell Lines

cells

Cell Fraction

Synaptosome: membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

IC50

Unit

nM

Quantitative value

1.2

Measurement pX

8.92

Concomitants: Compound RN

754371; 759557

Concomitants: Compound name

[3H]-Diazepam; Clonazepam

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p18507 + p14867

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

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284 of 976

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

4.6

Deviation

0.770000

Measurement pX

8.34

Concomitants: Compound RN

8080906; 4763661

Concomitants: Compound name

L-655,708; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit alpha-5 [human];+Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Synonyms

gaba(a) receptor subunit alpha-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5 + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2

Target Uniprot ID

p31644 + p18505 + p18507

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-5 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-5 [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

1.8

Deviation

0.0800000

Measurement pX

8.74

Concomitants: Compound RN

8080906; 4763661

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285 of 976

286 of 976

Concomitants: Compound name

L-655,708; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p18507

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Mutated:Substitution,1,Serine,205,Threonine

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

3.8

Deviation

1

Measurement pX

8.42

Concomitants: Compound RN

8080906; 4763661

Concomitants: Compound name

L-655,708; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p18507

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Mutated:Substitution,1,Valine,239,Isoleucine

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

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287 of 976

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

160

Deviation

41

Measurement pX

6.8

Concomitants: Compound RN

8080906; 4763661

Concomitants: Compound name

L-655,708; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p18507

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Mutated:Substitution,1,Serine,232,Threonine,Substitution,2,Valine,239,Isoleucine

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

3.1

Deviation

1.70000

Measurement pX

8.51

Concomitants: Compound RN

8080906; 4763661

Concomitants: Compound name

L-655,708; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

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288 of 976

289 of 976

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-5 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5

Target Uniprot ID

p18505 + p18507

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-5 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-5 [human]:Mutated:Substitution,1,Threonine,239,Serine,Substitution,2,Isoleucine,246,Valine

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

24

Deviation

8

Measurement pX

7.62

Concomitants: Compound RN

8080906; 4763661

Concomitants: Compound name

L-655,708; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

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290 of 976

291 of 976

Quantitative value

8.9

Deviation

0.900000

Measurement pX

8.05

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p63138 + p62813

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Mutated:Substitution,1,Alanine,117,Glycine + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

13

Deviation

3

Measurement pX

7.89

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p63138 + p62813

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292 of 976

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Mutated:Substitution,1,Alanine,117,Serine + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

15

Deviation

2

Measurement pX

7.82

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p63138 + p62813

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Mutated:Substitution,1,Alanine,117,Cysteine + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

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293 of 976

294 of 976

Unit

nM

Quantitative value

48

Deviation

5

Measurement pX

7.32

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p63138 + p62813

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Mutated:Substitution,1,Alanine,117,Glutamic acid + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

4.4

Deviation

1.60000

Measurement pX

8.36

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

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295 of 976

Target Uniprot ID

p63138 + p62813

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Mutated:Substitution,1,Alanine,117,Glutamine + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

79

Deviation

13

Measurement pX

7.1

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p63138 + p62813

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Mutated:Substitution,1,Alanine,117,Leucine + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

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296 of 976

297 of 976

Measurement Parameter

Ki

Unit

nM

Quantitative value

20

Deviation

3

Measurement pX

7.7

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p63138 + p62813

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Mutated:Substitution,1,Alanine,117,Phenylalanine + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

10

Deviation

1

Measurement pX

8

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

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+ gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

298 of 976

Target Uniprot ID

p63138 + p62813

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Mutated:Substitution,1,Alanine,117,Tyrosine + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

6.1

Deviation

2.20000

Measurement pX

8.21

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p63138 + p62813

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Mutated:Substitution,1,Alanine,117,Arginine + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

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299 of 976

300 of 976

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

24

Deviation

5

Measurement pX

7.62

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p63138 + p62813

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Mutated:Substitution,1,Alanine,117,Tryptophan + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

20

Deviation

4

Measurement pX

7.7

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit alpha-5 [human];+GABA-A receptor (Gamma 2S) [human]

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Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5 + gaba-a receptor (gamma 2s)

Target Uniprot ID

p28472 + p31644

Target PDB ID

4cof

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-5 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-5 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.19

Measurement pX

8.66

Concomitants: Compound RN

6182319; 6182319

Concomitants: Compound name

Ro 15-4513; [3H]-Ro 15-4513

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-5 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5

Target Uniprot ID

p28472

Target PDB ID

4cof

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-5 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-5 [human]:Mutated:Substitution,1,Lysine,105,Arginine

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

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Substance Name

flunitrazepam

Substance Dose

10 µM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

26

Measurement pX

4.55

Concomitants: Compound RN

6182319; 6182319

Concomitants: Compound name

Ro 15-4513; [3H]-Ro 15-4513

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit alpha-4 [human];+GABA-A receptor (Gamma 2S) [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-4; gabra4; gamma-aminobutyric acid receptor subunit alpha-4 + gaba-a receptor (gamma 2s)

Target Uniprot ID

p28472 + p48169

Target PDB ID

4cof

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-4 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-4 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

10 µM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

2

Measurement pX

1

Concomitants: Compound RN

6182319; 6182319

Concomitants: Compound name

Ro 15-4513; [3H]-Ro 15-4513

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit alpha-6 [human];+GABA-A receptor (Gamma 2S) [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-6; gabra6; gamma-aminobutyric acid receptor subunit alpha-6 + gaba-a receptor (gamma 2s)

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Target Uniprot ID

p28472 + q16445

Target PDB ID

4cof

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-6 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-6 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

10 µM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

6

Measurement pX

1

Concomitants: Compound RN

6182319; 6182319

Concomitants: Compound name

Ro 15-4513; [3H]-Ro 15-4513

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit alpha-5 [human];+GABA-A receptor (Gamma 2S) [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5 + gaba-a receptor (gamma 2s)

Target Uniprot ID

p28472 + p31644

Target PDB ID

4cof

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-5 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-5 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

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Measurement Parameter

% Stimulation

Unit

%

Quantitative value

147.2

Deviation

1.70000

Concomitants: Compound RN

24140623; 12471441; 3568341; 906818; 9186271

Concomitants: Compound name

Gentamycin; Streptomycin; Sodium pyruvate; GABA; Penicillin

Concomitants: Compound role

COM; COM; COM; AGO; COM

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-5 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5

Target Uniprot ID

p28472

Target PDB ID

4cof

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-5 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-5 [human]:Mutated:Substitution,1,Lysine,105,Arginine

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

5

Deviation

3

Concomitants: Compound RN

24140623; 12471441; 3568341; 906818; 9186271

Concomitants: Compound name

Gentamycin; Streptomycin; Sodium pyruvate; GABA; Penicillin

Concomitants: Compound role

COM; COM; COM; AGO; COM

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

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Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

3.9

Measurement pX

8.41

Concomitants: Compound RN

6182319; 702691

Concomitants: Compound name

[3H]-Ro 15-4513; Flunitrazepam

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

3.9

Measurement pX

8.41

Concomitants: Compound RN

6182319; 702691

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Concomitants: Compound name

[3H]-Ro 15-4513; Flunitrazepam

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

3.9

Deviation

0.800000

Measurement pX

8.41

Concomitants: Compound RN

6182319; 702691

Concomitants: Compound name

[3H]-Ro 15-4513; Flunitrazepam

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

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311 of 976

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

3.9

Deviation

0.800000

Measurement pX

8.41

Concomitants: Compound RN

6182319; 702691

Concomitants: Compound name

[3H]-Ro 15-4513; Flunitrazepam

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

3.9

Measurement pX

8.41

Concomitants: Compound RN

6182319; 702691

Concomitants: Compound name

[3H]-Ro 15-4513; Flunitrazepam

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

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Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

3.9

Measurement pX

8.41

Concomitants: Compound RN

6182319; 702691

Concomitants: Compound name

[3H]-Ro 15-4513; Flunitrazepam

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

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Quantitative value

3.9

Measurement pX

8.41

Concomitants: Compound RN

6182319; 702691

Concomitants: Compound name

[3H]-Ro 15-4513; Flunitrazepam

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

3.9

Deviation

0.800000

Measurement pX

8.41

Concomitants: Compound RN

6182319; 702691

Concomitants: Compound name

[3H]-Ro 15-4513; Flunitrazepam

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit alpha-6 [human];+Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human]

Target Synonyms

gaba(a) receptor subunit alpha-6; gabra6; gamma-aminobutyric acid receptor subunit alpha-6 + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s)

Target Uniprot ID

q16445 + p18505

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-6 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-6 [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild

Target Species (Bioactivity)

human

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316 of 976

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Qualitative value

>

Quantitative value

5000

Measurement pX

5.3

Concomitants: Compound RN

6182319; 702691

Concomitants: Compound name

[3H]-Ro 15-4513; Flunitrazepam

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1.00000E-11 M

Measurement Parameter

EC50

Unit

nM

Quantitative value

1.9

Measurement pX

8.72

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

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Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1.00000E-11 M

Measurement Parameter

% Max

Unit

%

Measurement Object

% of maximum potentiation

Quantitative value

104

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Mutated:Substitution,1,Histidine,129,Lysine

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1.00000E-11 M

Measurement Parameter

nH

Quantitative value

0.9

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Deviation

0.0800000

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Biological Species/NCBI ID

DBA 2 mouse

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

ID50

Unit

µmol/kg

Measurement Object

inhibition against clonic seizures

Quantitative value

0.22

De Sarro, Giovambattista; Carotti, Angelo; Campagna, Francesco; McKernan, Ruth; Rizzo, Milena; Falconi, Umberto; Palluotto, Fausta; Giusti, Pietro; Rettore, Cristina; De Sarro, Angela; Pharmacology Biochemistry and Behavior; vol. 65; nb. 3; (2000); p. 475 - 487, View in Reaxys 319 of 976

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Biological Species/NCBI ID

DBA 2 mouse

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

ID50

Unit

µmol/kg

Measurement Object

Dose required to inhibit tonic seizures

Quantitative value

0.18

De Sarro, Giovambattista; Carotti, Angelo; Campagna, Francesco; McKernan, Ruth; Rizzo, Milena; Falconi, Umberto; Palluotto, Fausta; Giusti, Pietro; Rettore, Cristina; De Sarro, Angela; Pharmacology Biochemistry and Behavior; vol. 65; nb. 3; (2000); p. 475 - 487, View in Reaxys 320 of 976

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Biological Species/NCBI ID

Swiss Webster mouse

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

ID50

Unit

µmol/kg

Measurement Object

inhibition of pentylenetetrazol induced clonic seizure

Quantitative value

0.29

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Concomitants: Compound RN

135492

Concomitants: Compound name

Pentetrazole

Concomitants: Compound role

IAV

De Sarro, Giovambattista; Carotti, Angelo; Campagna, Francesco; McKernan, Ruth; Rizzo, Milena; Falconi, Umberto; Palluotto, Fausta; Giusti, Pietro; Rettore, Cristina; De Sarro, Angela; Pharmacology Biochemistry and Behavior; vol. 65; nb. 3; (2000); p. 475 - 487, View in Reaxys 321 of 976

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Rotarod test

Biological Species/NCBI ID

Swiss Webster mouse

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

ED50

Unit

µmol/kg

Measurement Object

Induction of falling of the animals from the rota-rod

Quantitative value

8.7

De Sarro, Giovambattista; Carotti, Angelo; Campagna, Francesco; McKernan, Ruth; Rizzo, Milena; Falconi, Umberto; Palluotto, Fausta; Giusti, Pietro; Rettore, Cristina; De Sarro, Angela; Pharmacology Biochemistry and Behavior; vol. 65; nb. 3; (2000); p. 475 - 487, View in Reaxys 322 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Sprague Dawley rat

Organs/Tissues

cerebellum

Cell Fraction

Microsome: membrane (P3 fraction)

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

IC50

Unit

nM

Quantitative value

5

Deviation

2

Measurement pX

8.3

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

De Sarro, Giovambattista; Carotti, Angelo; Campagna, Francesco; McKernan, Ruth; Rizzo, Milena; Falconi, Umberto; Palluotto, Fausta; Giusti, Pietro; Rettore, Cristina; De Sarro, Angela; Pharmacology Biochemistry and Behavior; vol. 65; nb. 3; (2000); p. 475 - 487, View in Reaxys 323 of 976

Bioassay Category

In Vitro (Efficacy)

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Bioassay Name

Binding

Biological Species/NCBI ID

Sprague Dawley rat

Organs/Tissues

brain cortex

Cell Fraction

Microsome: membrane (P3 fraction)

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

IC50

Unit

nM

Quantitative value

7

Deviation

2

Measurement pX

8.15

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

De Sarro, Giovambattista; Carotti, Angelo; Campagna, Francesco; McKernan, Ruth; Rizzo, Milena; Falconi, Umberto; Palluotto, Fausta; Giusti, Pietro; Rettore, Cristina; De Sarro, Angela; Pharmacology Biochemistry and Behavior; vol. 65; nb. 3; (2000); p. 475 - 487, View in Reaxys 324 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Sprague Dawley rat

Organs/Tissues

spinal cord

Cell Fraction

Microsome: membrane (P3 fraction)

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

IC50

Qualitative value

ND

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

De Sarro, Giovambattista; Carotti, Angelo; Campagna, Francesco; McKernan, Ruth; Rizzo, Milena; Falconi, Umberto; Palluotto, Fausta; Giusti, Pietro; Rettore, Cristina; De Sarro, Angela; Pharmacology Biochemistry and Behavior; vol. 65; nb. 3; (2000); p. 475 - 487, View in Reaxys 325 of 976

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p63079 + p18508 + p62813

Target PDB ID

2pr9

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Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

3

Deviation

0.0300000

Measurement pX

8.52

Concomitants: Compound RN

702691; 4763661

Concomitants: Compound name

Flunitrazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

De Sarro, Giovambattista; Carotti, Angelo; Campagna, Francesco; McKernan, Ruth; Rizzo, Milena; Falconi, Umberto; Palluotto, Fausta; Giusti, Pietro; Rettore, Cristina; De Sarro, Angela; Pharmacology Biochemistry and Behavior; vol. 65; nb. 3; (2000); p. 475 - 487, View in Reaxys 326 of 976

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-2 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-2; gabra-2; gabra2; gamma-aminobutyric acid receptor subunit alpha-2

Target Uniprot ID

p63079 + p18508 + p23576

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

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Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

1.46

Deviation

0.560000

Measurement pX

8.84

Concomitants: Compound RN

702691; 4763661

Concomitants: Compound name

Flunitrazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

De Sarro, Giovambattista; Carotti, Angelo; Campagna, Francesco; McKernan, Ruth; Rizzo, Milena; Falconi, Umberto; Palluotto, Fausta; Giusti, Pietro; Rettore, Cristina; De Sarro, Angela; Pharmacology Biochemistry and Behavior; vol. 65; nb. 3; (2000); p. 475 - 487, View in Reaxys 327 of 976

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-3 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-3; gabra-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p63079 + p18508 + p20236

Target PDB ID

2pr9 + 4tk1; 4tk2; 4tk3; 4tk4; 4u90

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-3 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

1.66

Deviation

0.780000

Measurement pX

8.78

Concomitants: Compound RN

702691; 4763661

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Concomitants: Compound name

Flunitrazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

De Sarro, Giovambattista; Carotti, Angelo; Campagna, Francesco; McKernan, Ruth; Rizzo, Milena; Falconi, Umberto; Palluotto, Fausta; Giusti, Pietro; Rettore, Cristina; De Sarro, Angela; Pharmacology Biochemistry and Behavior; vol. 65; nb. 3; (2000); p. 475 - 487, View in Reaxys 328 of 976

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-5; gabra-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2

Target Uniprot ID

p63079 + p19969 + p18508

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

1.51

Deviation

0.300000

Measurement pX

8.82

Concomitants: Compound RN

702691; 4763661

Concomitants: Compound name

Flunitrazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

De Sarro, Giovambattista; Carotti, Angelo; Campagna, Francesco; McKernan, Ruth; Rizzo, Milena; Falconi, Umberto; Palluotto, Fausta; Giusti, Pietro; Rettore, Cristina; De Sarro, Angela; Pharmacology Biochemistry and Behavior; vol. 65; nb. 3; (2000); p. 475 - 487, View in Reaxys 329 of 976

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-6 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-6; gabra-6; gabra6; gamma-aminobutyric acid receptor subunit alpha-6 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2

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Target Uniprot ID

p63079 + p30191 + p18508

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-6 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-6 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Qualitative value

>

Quantitative value

10000

Measurement pX

1

Concomitants: Compound RN

702691; 4763661

Concomitants: Compound name

Flunitrazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

De Sarro, Giovambattista; Carotti, Angelo; Campagna, Francesco; McKernan, Ruth; Rizzo, Milena; Falconi, Umberto; Palluotto, Fausta; Giusti, Pietro; Rettore, Cristina; De Sarro, Angela; Pharmacology Biochemistry and Behavior; vol. 65; nb. 3; (2000); p. 475 - 487, View in Reaxys 330 of 976

Target Name

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p62813 + p18508 + p63138

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

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331 of 976

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

EC50

Unit

nM

Quantitative value

11.6

Measurement pX

7.94

Concomitants: Compound RN

906818; 906818

Concomitants: Compound name

GABA; GABA

Concomitants: Compound role

AGO; AGO

Target Name

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p18508 + p63138

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Mutated:Substitution,1,Proline,304,Alanine + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

EC50

Unit

nM

Quantitative value

5.8

Deviation

1.90000

Measurement pX

8.24

Concomitants: Compound RN

906818

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332 of 976

333 of 976

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p18508 + p63138

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Mutated:Substitution,1,Valine,306,Alanine + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

EC50

Unit

nM

Quantitative value

122

Deviation

6

Measurement pX

6.91

Concomitants: Compound RN

906818; 906818

Concomitants: Compound name

GABA; GABA

Concomitants: Compound role

AGO; AGO

Target Name

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p18508 + p63138

Target PDB ID

2pr9

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Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Mutated:Substitution,1,Alanine,307,Serine + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

EC50

Unit

nM

Quantitative value

6.8

Deviation

0.300000

Measurement pX

8.17

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p18508 + p63138

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Mutated:Substitution,1,Alanine,307,Serine + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

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Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

%

Unit

%

Measurement Object

Efficacy

Quantitative value

185

Deviation

1.42000

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p18508 + p63138

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Mutated:Substitution,1,Proline,304,Alanine + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

%

Unit

%

Measurement Object

Efficacy

Quantitative value

278

Deviation

17

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

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Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p18508 + p63138

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Mutated:Substitution,1,Valine,306,Alanine + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

%

Unit

%

Measurement Object

Efficacy

Quantitative value

375

Deviation

65

Concomitants: Compound RN

906818; 906818

Concomitants: Compound name

GABA; GABA

Concomitants: Compound role

AGO; AGO

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Mutated:Substitution,1,Histidine,129,Alanine

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Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

629

Deviation

103.300

Measurement pX

6.2

Concomitants: Compound RN

6182319; 702691

Concomitants: Compound name

[3H]-Ro 15-4513; Flunitrazepam

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Mutated:Substitution,1,Histidine,129,Valine

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

587

Deviation

83

Measurement pX

6.23

Concomitants: Compound RN

6182319; 702691

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Concomitants: Compound name

[3H]-Ro 15-4513; Flunitrazepam

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Mutated:Substitution,1,Histidine,129,Glutamic acid

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Qualitative value

>

Quantitative value

5000

Measurement pX

5.3

Concomitants: Compound RN

6182319; 702691

Concomitants: Compound name

[3H]-Ro 15-4513; Flunitrazepam

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Mutated:Substitution,1,Histidine,129,Glutamine

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

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Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Qualitative value

>

Quantitative value

5000

Measurement pX

5.3

Concomitants: Compound RN

6182319; 702691

Concomitants: Compound name

[3H]-Ro 15-4513; Flunitrazepam

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Mutated:Substitution,1,Histidine,129,Methionine

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

1660

Deviation

770

Measurement pX

5.78

Concomitants: Compound RN

6182319; 702691

Concomitants: Compound name

[3H]-Ro 15-4513; Flunitrazepam

Concomitants: Compound role

RAD; NSB

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Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Mutated:Substitution,1,Histidine,129,Lysine

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

4390

Deviation

850

Measurement pX

5.36

Concomitants: Compound RN

6182319; 702691

Concomitants: Compound name

[3H]-Ro 15-4513; Flunitrazepam

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Mutated:Substitution,1,Histidine,129,Tyrosine

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

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345 of 976

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

1380

Deviation

300

Measurement pX

5.86

Concomitants: Compound RN

6182319; 702691

Concomitants: Compound name

[3H]-Ro 15-4513; Flunitrazepam

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Mutated:Substitution,1,Histidine,129,Arginine

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Qualitative value

>

Quantitative value

5000

Measurement pX

5.3

Concomitants: Compound RN

6182319; 702691

Concomitants: Compound name

[3H]-Ro 15-4513; Flunitrazepam

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

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Target Uniprot ID

p18505

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Mutated:Substitution,1,Histidine,129,Lysine

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1.00000E-11 M

Measurement Parameter

EC50

Unit

nM

Quantitative value

813

Measurement pX

6.09

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Mutated:Substitution,1,Histidine,129,Lysine

Target Species (Bioactivity)

human

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1.00000E-11 M

Measurement Parameter

% Max

Unit

%

Measurement Object

% of maximum potentiation

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Quantitative value

91

Deviation

6.70000

Substance Effect

Sedative

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Spontaneous activity

Biological Species/NCBI ID

C57BL 6 mouse

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

of times a mouse interrupted the photosensor beams

Quantitative value

56

Deviation

14

Statistical sgnificance (pvalue)

0.01

Harris, Danni L.; Delorey, Timothy M.; He, Xiaohui; Cook, James M.; Loew, Gilda H.; European Journal of Pharmacology; vol. 401; nb. 3; (2000); p. 271 - 287, View in Reaxys 348 of 976

Target Name

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p18508 + p63138

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Mutated:Substitution,1,Valine,306,Alanine + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

EC50

Unit

nM

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349 of 976

350 of 976

Quantitative value

40.5

Deviation

7.70000

Statistical sgnificance (pvalue)

0.01

Measurement pX

7.39

Concomitants: Compound RN

906818; 906818

Concomitants: Compound name

GABA; GABA

Concomitants: Compound role

AGO; AGO

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

CD rat

Organs/Tissues

brain cortex

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

11

Measurement Parameter

Ki

Unit

nM

Quantitative value

10

Deviation

0.400000

Measurement pX

8

Concomitants: Compound RN

4264456; 8951860

Concomitants: Compound name

PK 11195; [3H]-CB 34

Concomitants: Compound role

NSB; RAD

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

thalamus

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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351 of 976

352 of 976

Unit

nM

Quantitative value

2.9

Deviation

0.200000

Measurement pX

8.54

Concomitants: Compound RN

6182319; 6158829

Concomitants: Compound name

[3H]-Ro 15-4513; Bretazenil

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-4 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-4; gabra4; gamma-aminobutyric acid receptor subunit alpha-4

Target Uniprot ID

p18508 + p28471

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-4 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-4 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

thalamus

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Qualitative value

ND

Concomitants: Compound RN

6182319; 6158829

Concomitants: Compound name

[3H]-Ro 15-4513; Bretazenil

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit alpha-4 [human];+GABA-A receptor (Gamma 2S) [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-4; gabra4; gamma-aminobutyric acid receptor subunit alpha-4 + gaba-a receptor (gamma 2s)

Target Uniprot ID

p28472 + p48169

Target PDB ID

4cof

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-4 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-4 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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353 of 976

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

12

Deviation

1

Measurement pX

1

Concomitants: Compound RN

6182319; 6158829

Concomitants: Compound name

[3H]-Ro 15-4513; Bretazenil

Concomitants: Compound role

RAD; NSB

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

thalamus

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

11

Deviation

2

Measurement pX

1

Concomitants: Compound RN

6182319; 6158829

Concomitants: Compound name

[3H]-Ro 15-4513; Bretazenil

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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354 of 976

Concomitants: Compound role

RAD; NSB

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

sleep latency in rats placed on sawdust

Quantitative value

19

Deviation

2.90000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 355 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

sleep latency in rats placed on sawdust

Quantitative value

16.9

Deviation

4.20000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 356 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

sleep latency in rats placed on sawdust

Quantitative value

17.2

Deviation

3

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 357 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

sleep latency in rats placed on sawdust

Quantitative value

11.5

Deviation

1.70000

Statistical sgnificance (pvalue)

0.05

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 358 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

sleep latency in rats placed on a grid suspended over water

Quantitative value

34.6

Deviation

4.50000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 359 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

sleep latency in rats placed on a grid suspended over water

Quantitative value

33.6

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Deviation

6.40000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 360 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

sleep latency in rats placed on a grid suspended over water

Quantitative value

18.6

Deviation

2.90000

Statistical sgnificance (pvalue)

0.01

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 361 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

213/493

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Measurement Object

sleep latency in rats placed on a grid suspended over water

Quantitative value

16.2

Deviation

4.30000

Statistical sgnificance (pvalue)

0.01

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 362 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

32.5

Deviation

2.40000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 363 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

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214/493

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Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

31.6

Deviation

2.20000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 364 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

34.3

Deviation

1.30000

Statistical sgnificance (pvalue)

0.05

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 365 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

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215/493

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Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

38.3

Deviation

1.20000

Statistical sgnificance (pvalue)

0.01

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 366 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

39.4

Deviation

2.60000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 367 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

216/493

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Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

37.3

Deviation

2.50000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 368 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

38.4

Deviation

1.80000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 369 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

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217/493

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Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

38.8

Deviation

1.80000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 370 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

39.6

Deviation

2.20000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 371 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

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Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

38.4

Deviation

2.60000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 372 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

40.4

Deviation

0.800000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 373 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

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Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

36.7

Deviation

1.20000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 374 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

34.4

Deviation

2.10000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 375 of 976

Substance Effect

Hypnotic

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

220/493

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Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

36.9

Deviation

2

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 376 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

36.8

Deviation

2.80000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

221/493

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377 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

38.7

Deviation

1.40000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 378 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

33.6

Deviation

3

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

222/493

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Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 379 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

38.2

Deviation

1.40000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 380 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

32.9

Deviation

3.20000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

223/493

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Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 381 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

39

Deviation

1.10000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 382 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

30.2

Deviation

3.30000

Concomitants: Compound RN

24141036

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

224/493

2018-04-14 18:48:42


Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 383 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

36.4

Deviation

1.80000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 384 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

38.7

Deviation

1.60000

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

225/493

2018-04-14 18:48:42


Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 385 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

37.2

Deviation

1.20000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 386 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

26.7

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

226/493

2018-04-14 18:48:42


Deviation

2.70000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 387 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

26.7

Deviation

1.10000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 388 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

227/493

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Quantitative value

31.1

Deviation

1.70000

Statistical sgnificance (pvalue)

0.05

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 389 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

31.5

Deviation

2.50000

Statistical sgnificance (pvalue)

0.01

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 390 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

228/493

2018-04-14 18:48:42


Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

24.5

Deviation

2.30000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 391 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

24.6

Deviation

2

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 392 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

229/493

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Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

31.2

Deviation

1.20000

Statistical sgnificance (pvalue)

0.05

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 393 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

33.6

Deviation

1.50000

Statistical sgnificance (pvalue)

0.01

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 394 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

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230/493

2018-04-14 18:48:42


Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

19.5

Deviation

2.80000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 395 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

25.8

Deviation

1.40000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 396 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

231/493

2018-04-14 18:48:42


Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

26.8

Deviation

2.10000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 397 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

28.1

Deviation

1.50000

Statistical sgnificance (pvalue)

0.05

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

232/493

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398 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

24.8

Deviation

0.600000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 399 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

25.7

Deviation

2.50000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 400 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

20.5

Deviation

1.40000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 401 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

24.5

Deviation

1.60000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

234/493

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Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 402 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

21.6

Deviation

2.60000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 403 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

18.2

Deviation

2.20000

Concomitants: Compound RN

24141036

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

235/493

2018-04-14 18:48:42


Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 404 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

23.2

Deviation

2.40000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 405 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep for rats placed on sawdust

Quantitative value

24.8

Deviation

1.50000

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

236/493

2018-04-14 18:48:42


Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 406 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep in rats placed on a grid suspended over water

Quantitative value

23.3

Deviation

1.50000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 407 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep in rats placed on a grid suspended over water

Quantitative value

28.8

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Deviation

1.50000

Statistical sgnificance (pvalue)

0.01

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 408 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep in rats placed on a grid suspended over water

Quantitative value

29.8

Deviation

1.60000

Statistical sgnificance (pvalue)

0.01

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 409 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

238/493

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Measurement Parameter

Time

Unit

minute

Measurement Object

non-REM sleep in rats placed on a grid suspended over water

Quantitative value

31.1

Deviation

2.50000

Statistical sgnificance (pvalue)

0.01

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 410 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

second

Measurement Object

non-REM sleep episode duration in rats placed on sandwust

Quantitative value

43.3

Deviation

4.70000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 411 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

239/493

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Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

second

Measurement Object

non-REM sleep episode duration in rats placed on sandwust

Quantitative value

46.9

Deviation

2.70000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 412 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

second

Measurement Object

non-REM sleep episode duration in rats placed on sandwust

Quantitative value

44.4

Deviation

4.90000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 413 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

240/493

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Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

second

Measurement Object

non-REM sleep episode duration in rats placed on sandwust

Quantitative value

43.5

Deviation

3.40000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 414 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

second

Measurement Object

non-REM sleep episode duration in rats placed on a grid suspended over water

Quantitative value

30.1

Deviation

1.10000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 415 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

241/493

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Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

second

Measurement Object

non-REM sleep episode duration in rats placed on a grid suspended over water

Quantitative value

29.5

Deviation

0.800000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 416 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

second

Measurement Object

non-REM sleep episode duration in rats placed on a grid suspended over water

Quantitative value

32.3

Deviation

1.60000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 417 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

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242/493

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Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

second

Measurement Object

non-REM sleep episode duration in rats placed on a grid suspended over water

Quantitative value

29.9

Deviation

1.30000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 418 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

non-REM sleep episode duration in rats placed on sandwust

Quantitative value

304.3

Deviation

21.9000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 419 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

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243/493

2018-04-14 18:48:42


Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

non-REM sleep episode duration in rats placed on sandwust

Quantitative value

282.8

Deviation

13.9000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 420 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

non-REM sleep episode duration in rats placed on sandwust

Quantitative value

311.1

Deviation

20.8000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 421 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

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244/493

2018-04-14 18:48:42


Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

non-REM sleep episode duration in rats placed on sandwust

Quantitative value

321.5

Deviation

19.1000

Statistical sgnificance (pvalue)

0.05

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 422 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

non-REM sleep episode duration in rats placed on a grid suspended over water

Quantitative value

273.5

Deviation

7.80000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 423 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

245/493

2018-04-14 18:48:42


Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

non-REM sleep episode duration in rats placed on a grid suspended over water

Quantitative value

300.1

Deviation

13.9000

Statistical sgnificance (pvalue)

0.01

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 424 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

non-REM sleep episode duration in rats placed on a grid suspended over water

Quantitative value

296.3

Deviation

8

Statistical sgnificance (pvalue)

0.01

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 425 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

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Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

non-REM sleep episode duration in rats placed on a grid suspended over water

Quantitative value

335.1

Deviation

4.10000

Statistical sgnificance (pvalue)

0.01

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 426 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

second

Measurement Object

REM sleep episode duration in rats placed on sandwust

Quantitative value

14.4

Deviation

1

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 427 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

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Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

second

Measurement Object

REM sleep episode duration in rats placed on sandwust

Quantitative value

14.4

Deviation

0.900000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 428 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

second

Measurement Object

REM sleep episode duration in rats placed on sandwust

Quantitative value

13

Deviation

0.700000

Statistical sgnificance (pvalue)

0.01

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys

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429 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

second

Measurement Object

REM sleep episode duration in rats placed on sandwust

Quantitative value

12.1

Deviation

0.500000

Statistical sgnificance (pvalue)

0.01

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 430 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

second

Measurement Object

REM sleep episode duration in rats placed on a grid suspended over water

Quantitative value

17.3

Deviation

1.30000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

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Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 431 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

second

Measurement Object

REM sleep episode duration in rats placed on a grid suspended over water

Quantitative value

17.9

Deviation

1.50000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 432 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

second

Measurement Object

REM sleep episode duration in rats placed on a grid suspended over water

Quantitative value

15.6

Deviation

1.20000

Concomitants: Compound RN

24141036

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Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 433 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Time

Unit

second

Measurement Object

REM sleep episode duration in rats placed on a grid suspended over water

Quantitative value

14.5

Deviation

1.10000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 434 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

REM sleep episode duration in rats placed on sandwust

Quantitative value

115

Deviation

10

Concomitants: Compound RN

24141036

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Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 435 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

REM sleep episode duration in rats placed on sandwust

Quantitative value

126.8

Deviation

6.90000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 436 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

REM sleep episode duration in rats placed on sandwust

Quantitative value

112.9

Deviation

7.90000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

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Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 437 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

REM sleep episode duration in rats placed on sandwust

Quantitative value

91.1

Deviation

10.3000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 438 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

REM sleep episode duration in rats placed on a grid suspended over water

Quantitative value

49.5

Deviation

6.50000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

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Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 439 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

REM sleep episode duration in rats placed on a grid suspended over water

Quantitative value

57.3

Deviation

8

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 440 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

REM sleep episode duration in rats placed on a grid suspended over water

Quantitative value

42.8

Deviation

2.90000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

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Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 441 of 976

Substance Effect

Hypnotic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Sedation

Biological Species/NCBI ID

Wistar rat

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

5 mg/kg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Number

Measurement Object

REM sleep episode duration in rats placed on a grid suspended over water

Quantitative value

65.4

Deviation

10.2000

Concomitants: Compound RN

24141036

Concomitants: Compound name

Pentobarbital sodium

Concomitants: Compound role

ANA

Shinomiya, Kazuaki; Shigemoto, Yuki; Omichi, Junji; Utsu, Yoshiaki; Mio, Mitsunobu; Kamei, Chiaki; Psychopharmacology; vol. 173; nb. 1-2; (2004); p. 203 - 209, View in Reaxys 442 of 976

Substance Effect

Behavioural Symptoms

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Target : Long-Evans ratBioassay : GHB: α-hydroxybutyrate title comp. was administered 1 week before, during (1000 mg/kg i.p. for 1 week) and 2 weeks after GHB treatment; motor performance (latency to fall) was recorded at both low (8 rpm) and high (32 rpm) speeds; rotorod assay

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.0100000 mg/kg

Substance Route of Adm.

intraperitoneal administration

Qualitative Results

title comp. dose-dependently decreased motor performance at both speeds, but was 4.6-15 fold more potent at high speed; GHB treatment did not alter potency of title comp.

Measurement Parameter

Qualitative

Smith, Mark A.; Gergans, Samantha R.; Lyle, Megan A.; European Journal of Pharmacology; vol. 552; nb. 1-3; (2006); p. 83 - 89, View in Reaxys 443 of 976

Target Name

UDP-glucuronosyltransferase [human]

Target Synonyms

udp-glucuronosyltransferase 1a9; udp-glucuronosyltransferase; udp-glucuronosyltransferase variant; ugt1a1; ugt1a10; ugt1a3; ugt1a4; ugt1a6; ugt1a7; ugt1a9; ugt1g; ugt1j; ugt2a1; ugt2b7; ugt3a1

Target Uniprot ID

a0a024rdc9; a3kme6; b4ddy2; b4dzz5; b5mct4; b7z3n0; b7z8q8; d6rfw5; d6rh08; e9pd17; i6u9t8; i6ujg0; i6v2c0; i6vbt8; i6vbu3; i6vbu7; i6ve22; i6ve27; q0vaj1; q13406; q13407; q4r0z5; q4r0z7; q53e75; q53gq9; q53gu2; q5dsz7; q5dsz8; q5dsz9; q5dt01; q5dt02; q5dt03; q5k632; q5k672; q5k673; q5k674; q5qte0; q5qte1; q5qte2; q5qte4; q75xt5; q8wuq4; q8wx86; q8wx88; q8wx89; q8wx90; q9h3f9; q9h3g0; q9h3g1; q9h3g2

Target, Subunit, Species

UDP-glucuronosyltransferase [human]

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444 of 976

Target Mutant/Chimera Details

UDP-glucuronosyltransferase [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0 mM

Measurement Parameter

Ki

Unit

mM

Quantitative value

0.19

Deviation

0.0300000

Measurement pX

3.72

Metabolite RN

7452311

Metabolite name

Zidovudine glucuronide

Concomitants: Compound RN

3595791; 78881

Concomitants: Compound name

Zidovudine; Uridine 5'-diphosphoglucuronic acid

Concomitants: Compound role

SUB; COM

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : gaba-A, Benzodiazepine (Central) receptor bindingTarget : Receptor source - bovine cortical membranesBioassay : [00100] Experiment 6-Bioactivity of Infused Agents-Pharmacology Activity Test [00101] It was demonstrated that introduced drugs and drug-like agents can maintain their pharmacological activity during their residence in the biological materials. The following procedures were employed and the following

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

Flunitrazepam, a hypnotic, demonstrated specific binding in the benzodiazepine central assay

Measurement Parameter

Qualitative

Patent; American Moxie LLC; US6660310; (2003); (B2) English, View in Reaxys 445 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Bioassay Details

Effect : |receptor; binding activity Target : embryos from 14-day-old C57B1/6CR mouseBioassay : non specific binding was detn. in presence of 10 μM Ro15-1788 coverslips contg. cortical cultured neurons pretreated with pentobarbital (200 μM, 5-days), or not (control) removed from the tissue culture medium rinsed at room temp. in HEPES-buffered saline, incubated with (3H)title comp. for 30 min at 24 deg C

Substance RN

702691View in Reaxys

Substance Name

31870

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Substance Dose

1 nM

Qualitative Results

specific binding: control 141 fmol/mg protein; in cells pretreated with 200 μM pentobarbital for 5 days 154 fmol/mg protein; chronic pretreatment with pentobarbital did not change basal title comp. binding to intact cortical neurons

Measurement Parameter

Qualitative

Yu; Ticku; Journal of Pharmacology and Experimental Therapeutics; vol. 275; nb. 3; (1995); p. 1442 - 1446, View in Reaxys 446 of 976

Substance Effect

Anticonvulsant

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Effect : seizure stageBioassay : AD: afterdischarge bipolar electrodes implanted into right amygdala of rats; stimulation: 60 Hz, 1 ms and 1 s duration at intensity sufficient to induce AD; stimulation performed 1 h after title comp. administration; amygdaloid kindling classified by Racine method

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.500000 mg/kg

Substance Route of Adm.

oral administration

Measurement Parameter

ED50

Unit

mg/kg

Quantitative value

0.89

Fukinaga, Masafumi; Ishizawa, Keisuke; Kamei, Chiaki; Pharmacology; vol. 57; nb. 5; (1998); p. 233 - 241, View in Reaxys 447 of 976

Target Name

Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p14867

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

cells

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.2

Measurement pX

8.66

Concomitants: Compound RN

702691; 4763661

Concomitants: Compound name

Flunitrazepam; [3H]-Ro 15-1788

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Concomitants: Compound role

NSB; RAD

Atack, John R.; Smith, Alison J.; Emms, Frances; McKernan, Ruth M.; Neuropsychopharmacology; vol. 20; nb. 3; (1999); p. 255 - 262, View in Reaxys 448 of 976

Target Name

Gamma-aminobutyric acid receptor subunit alpha-2 [human]

Target Synonyms

gaba(a) receptor subunit alpha-2; gabra2; gamma-aminobutyric acid receptor subunit alpha-2

Target Uniprot ID

p47869

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-2 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

cells

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.5

Measurement pX

8.6

Concomitants: Compound RN

702691; 4763661

Concomitants: Compound name

Flunitrazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Atack, John R.; Smith, Alison J.; Emms, Frances; McKernan, Ruth M.; Neuropsychopharmacology; vol. 20; nb. 3; (1999); p. 255 - 262, View in Reaxys 449 of 976

Target Name

Gamma-aminobutyric acid receptor subunit alpha-3 [human]

Target Synonyms

gaba(a) receptor subunit alpha-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p34903

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-3 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-3 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

cells

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Measurement Parameter

Ki

Unit

nM

Quantitative value

4.5

Measurement pX

8.35

Concomitants: Compound RN

702691; 4763661

Concomitants: Compound name

Flunitrazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Atack, John R.; Smith, Alison J.; Emms, Frances; McKernan, Ruth M.; Neuropsychopharmacology; vol. 20; nb. 3; (1999); p. 255 - 262, View in Reaxys 450 of 976

Target Name

Gamma-aminobutyric acid receptor subunit alpha-5 [human]

Target Synonyms

gaba(a) receptor subunit alpha-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5

Target Uniprot ID

p31644

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-5 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-5 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

cells

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.1

Measurement pX

8.68

Concomitants: Compound RN

702691; 4763661

Concomitants: Compound name

Flunitrazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Atack, John R.; Smith, Alison J.; Emms, Frances; McKernan, Ruth M.; Neuropsychopharmacology; vol. 20; nb. 3; (1999); p. 255 - 262, View in Reaxys 451 of 976

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In Vivo: Binding

Biological Species/NCBI ID

Swiss Webster mouse

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Route of Adm.

intraperitoneal administration

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Substance Dosing Regimen

Single

Measurement Parameter

ID50

Unit

mg/kg

Quantitative value

0.2 - 0.3

Concomitants: Compound RN

4763661

Concomitants: Compound name

[3H]-Ro 15-1788

Concomitants: Compound role

OCV

Atack, John R.; Smith, Alison J.; Emms, Frances; McKernan, Ruth M.; Neuropsychopharmacology; vol. 20; nb. 3; (1999); p. 255 - 262, View in Reaxys 452 of 976

453 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

brain

Cells/Cell Lines

cells

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0.300000 nM

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.3

Deviation

0.500000

Measurement pX

8.64

Concomitants: Compound RN

702691; 702691

Concomitants: Compound name

Flunitrazepam; [3H]-Flunitrazepam

Concomitants: Compound role

NSB; RAD

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Mus musculus

Organs/Tissues

brain

Cells/Cell Lines

cells

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0.300000 nM

Measurement Parameter

Ki

Unit

nM

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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454 of 976

455 of 976

Quantitative value

2.3

Deviation

0.500000

Measurement pX

8.64

Concomitants: Compound RN

702691; 702691

Concomitants: Compound name

Flunitrazepam; [3H]-Flunitrazepam

Concomitants: Compound role

NSB; RAD

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In Vivo: Binding

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0.300000 nM

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

ID50

Unit

µmol/kg

Quantitative value

1.69

Deviation

0.970000

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

OCV

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Brain biochemistry : Others

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0.320000 µmol/kg

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

Concentration

Unit

µmol/kg

Measurement Object

of [3H]-flunitrazepam

Quantitative value

0.13

Deviation

0.0200000

Concomitants: Compound RN

702691

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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456 of 976

457 of 976

458 of 976

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

OCV

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Brain biochemistry : Others

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

3.20000 µmol/kg

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

Concentration

Unit

µmol/kg

Measurement Object

of [3H]-flunitrazepam

Quantitative value

1.4

Deviation

1

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

OCV

Bioassay Category

In Vivo (Animal models)

Bioassay Name

Brain biochemistry : Others

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

32 µmol/kg

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

Concentration

Unit

µmol/kg

Measurement Object

of [3H]-flunitrazepam

Quantitative value

6.3

Deviation

4

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

OCV

Bioassay Category

In Vivo (Animal models)

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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459 of 976

460 of 976

Bioassay Name

In Vivo: Binding

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0.0318000 µmol/kg

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

7

Deviation

7

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

OCV

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In Vivo: Binding

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0.318000 µmol/kg

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

12

Deviation

8

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

OCV

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In Vivo: Binding

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

3.18000 µmol/kg

Substance Route of Adm.

intraperitoneal administration

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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461 of 976

462 of 976

Substance Dosing Regimen

Single

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

78

Deviation

8

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

OCV

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In Vivo: Binding

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

9.55000 µmol/kg

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

85

Deviation

1

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

OCV

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In Vivo: Binding

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

31.8000 µmol/kg

Substance Route of Adm.

intraperitoneal administration

Substance Dosing Regimen

Single

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

92

Deviation

4

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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463 of 976

464 of 976

Concomitants: Compound RN

702691

Concomitants: Compound name

[3H]-Flunitrazepam

Concomitants: Compound role

OCV

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit beta-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18507 + p47870 + p14867

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

3

Deviation

0.800000

Measurement pX

8.52

Concomitants: Compound RN

4763661; 4763661

Concomitants: Compound name

Flumazenil; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Synonyms

gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2

Target Uniprot ID

p47870 + p14867

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Mutated:Substitution,1,Phenylalanine,116,Tyrosine

Target Species (Bioactivity)

human

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465 of 976

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

502

Deviation

2

Measurement pX

6.3

Concomitants: Compound RN

4763661; 4763661

Concomitants: Compound name

Flumazenil; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Synonyms

gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2

Target Uniprot ID

p47870 + p14867

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Mutated:Substitution,1,Phenylalanine,116,Leucine

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

7.2

Deviation

3.20000

Measurement pX

8.14

Concomitants: Compound RN

4763661; 4763661

Concomitants: Compound name

Flumazenil; [3H]-Ro 15-1788

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466 of 976

467 of 976

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Synonyms

gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2

Target Uniprot ID

p47870 + p14867

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Mutated:Substitution,1,Phenylalanine,116,Isoleucine

Target Species (Bioactivity)

human

Target Transfection

Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flunitrazepam

Measurement Parameter

Kd

Unit

nM

Quantitative value

4.5

Deviation

0.700000

Measurement pX

8.35

Concomitants: Compound RN

702691

Concomitants: Compound name

Flunitrazepam

Concomitants: Compound role

NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Synonyms

gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2

Target Uniprot ID

p47870 + p14867

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Mutated:Substitution,1,Phenylalanine,116,Tryptophan

Target Species (Bioactivity)

human

Target Transfection

Transfected

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468 of 976

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flunitrazepam

Measurement Parameter

Kd

Unit

nM

Quantitative value

18

Deviation

4.30000

Measurement pX

7.74

Concomitants: Compound RN

702691

Concomitants: Compound name

Flunitrazepam

Concomitants: Compound role

NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Synonyms

gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2

Target Uniprot ID

p47870 + p14867

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Mutated:Substitution,1,Phenylalanine,116,Tryptophan

Target Species (Bioactivity)

human

Target Transfection

Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flunitrazepam

Measurement Parameter

nH

Quantitative value

1

Concomitants: Compound RN

702691

Concomitants: Compound name

Flunitrazepam

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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469 of 976

470 of 976

Concomitants: Compound role

NSB

Target Name

GABA-A receptor (Gamma 1) [human];+Gamma-aminobutyric acid receptor subunit beta-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba-a receptor (gamma 1) + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p47870 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 1) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 1) [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

3H-Flunitrazepam

Measurement Parameter

Kd

Unit

µM

Quantitative value

37.74

Deviation

5.07000

Measurement pX

4.42

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18508 + p63138 + p62813

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Substance RN

702691View in Reaxys

Substance Name

2

Measurement Parameter

Ki

Unit

nM

Quantitative value

3

Measurement pX

8.52

Concomitants: Compound RN

4763661; 4763661

Concomitants: Compound name

Flumazenil; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Sigel, Erwin; Schaerer, Martin T.; Buhr, Andreas; Baur, Roland; Molecular Pharmacology; vol. 54; nb. 6; (1998); p. 1097 1105, View in Reaxys 471 of 976

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p63138 + p62813

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Mutated:Substitution,1,Phenylalanine,115,Tyrosine + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

2

Measurement Parameter

Ki

Unit

nM

Quantitative value

500

Measurement pX

6.3

Concomitants: Compound RN

4763661; 4763661

Concomitants: Compound name

Flumazenil; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Sigel, Erwin; Schaerer, Martin T.; Buhr, Andreas; Baur, Roland; Molecular Pharmacology; vol. 54; nb. 6; (1998); p. 1097 1105, View in Reaxys

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472 of 976

Target Name

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p18508 + p63138

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Mutated:Substitution,1,Threonine,233,Valine + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

2

Measurement Parameter

Ki

Unit

nM

Quantitative value

36

Measurement pX

7.44

Concomitants: Compound RN

4763661; 4763661

Concomitants: Compound name

Flumazenil; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Sigel, Erwin; Schaerer, Martin T.; Buhr, Andreas; Baur, Roland; Molecular Pharmacology; vol. 54; nb. 6; (1998); p. 1097 1105, View in Reaxys 473 of 976

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p63138 + p62813

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Mutated:Substitution,1,Methionine,168,Leucine + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

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Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

2

Measurement Parameter

Ki

Unit

nM

Quantitative value

8

Measurement pX

8.1

Concomitants: Compound RN

4763661; 4763661

Concomitants: Compound name

Flumazenil; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Sigel, Erwin; Schaerer, Martin T.; Buhr, Andreas; Baur, Roland; Molecular Pharmacology; vol. 54; nb. 6; (1998); p. 1097 1105, View in Reaxys 474 of 976

Target Name

Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus];+GABA-A receptor (Gamma 2S) [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba-a receptor (gamma 2s)

Target Uniprot ID

p63138 + p62813

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Wild + GABA-A receptor (Gamma 2S) [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flunitrazepam

Measurement Parameter

Kd

Unit

nM

Quantitative value

9.9

Deviation

0.800000

Measurement pX

8

Concomitants: Compound RN

767925

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475 of 976

476 of 976

Concomitants: Compound name

Flurazepam

Concomitants: Compound role

NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus];+GABA-A receptor (Gamma 2S) [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba-a receptor (gamma 2s)

Target Uniprot ID

p63138 + p62813

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Wild + GABA-A receptor (Gamma 2S) [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flunitrazepam

Measurement Parameter

Bmax

Unit

pmol/mg

Quantitative value

0.65

Deviation

0.0700000

Concomitants: Compound RN

767925

Concomitants: Compound name

Flurazepam

Concomitants: Compound role

NSB

Target Name

GABA-A receptor [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Synonyms

gaba-a receptor + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p63138

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Chimera + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Substance Action on Target

Radioligand (/ligand)

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477 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flunitrazepam

Measurement Parameter

Kd

Unit

nM

Quantitative value

11.3

Deviation

1.70000

Measurement pX

7.95

Concomitants: Compound RN

767925

Concomitants: Compound name

Flurazepam

Concomitants: Compound role

NSB

Target Name

GABA-A receptor [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Synonyms

gaba-a receptor + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p63138

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Chimera + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flunitrazepam

Measurement Parameter

Bmax

Unit

pmol/mg

Quantitative value

0.34

Deviation

0.0300000

Concomitants: Compound RN

767925

Concomitants: Compound name

Flurazepam

Concomitants: Compound role

NSB

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478 of 976

479 of 976

Target Name

GABA-A receptor [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Synonyms

gaba-a receptor + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p63138

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Chimera + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flunitrazepam

Measurement Parameter

Kd

Unit

nM

Quantitative value

13.3

Deviation

3.50000

Measurement pX

7.88

Concomitants: Compound RN

767925

Concomitants: Compound name

Flurazepam

Concomitants: Compound role

NSB

Target Name

GABA-A receptor [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Synonyms

gaba-a receptor + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p63138

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Chimera + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

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480 of 976

481 of 976

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flunitrazepam

Measurement Parameter

Bmax

Unit

pmol/mg

Quantitative value

0.57

Deviation

0.170000

Concomitants: Compound RN

767925

Concomitants: Compound name

Flurazepam

Concomitants: Compound role

NSB

Target Name

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p18508 + p63138

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Mutated:Substitution,1,Tyrosine,236,Alanine + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Qualitative value

ND

Concomitants: Compound RN

4763661; 4763661

Concomitants: Compound name

Flumazenil; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit

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gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

482 of 976

Target Uniprot ID

p18508 + p63138

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Mutated:Substitution,1,Tyrosine,236,Glutamine + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Qualitative value

>

Quantitative value

100

Measurement pX

7

Concomitants: Compound RN

606417; 774694

Concomitants: Compound name

Muscimol; [3H]-Muscimol

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p18508 + p63138

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Mutated:Substitution,1,Tyrosine,236,Phenylalanine + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

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483 of 976

484 of 976

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Qualitative value

ND

Concomitants: Compound RN

4763661; 4763661

Concomitants: Compound name

Flumazenil; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p18508 + p63138

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Mutated:Substitution,1,Threonine,233,Alanine + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Qualitative value

ND

Concomitants: Compound RN

4763661; 4763661

Concomitants: Compound name

Flumazenil; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18505 + p18507 + p14867

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485 of 976

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flunitrazepam

Measurement Parameter

Kd

Unit

nM

Quantitative value

9.3

Deviation

1.40000

Measurement pX

8.03

Concomitants: Compound RN

6182319

Concomitants: Compound name

Ro 15-4513

Concomitants: Compound role

NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p28472 + p18507 + p14867

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

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486 of 976

487 of 976

Substance Name

[3H]-Flunitrazepam

Measurement Parameter

Kd

Unit

nM

Quantitative value

15.3

Deviation

2.30000

Measurement pX

7.82

Concomitants: Compound RN

6182319

Concomitants: Compound name

Ro 15-4513

Concomitants: Compound role

NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit alpha-6 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-6; gabra6; gamma-aminobutyric acid receptor subunit alpha-6 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2

Target Uniprot ID

p28472 + q16445 + p18507

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-6 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-6 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flunitrazepam

Measurement Parameter

Kd

Qualitative value

ND

Concomitants: Compound RN

6182319

Concomitants: Compound name

Ro 15-4513

Concomitants: Compound role

NSB

Target Name

GABA-A receptor [taurine cattle]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [taurine cattle]

Target Mutant/Chimera Details

GABA-A receptor [taurine cattle]:Wild

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488 of 976

Target Species (Bioactivity)

taurine cattle

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

taurine cattle

Organs/Tissues

brain cortex

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

fluni

Substance Dose

10 µM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

100

Deviation

5.20000

Measurement pX

6.28

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

GABA-A receptor [taurine cattle]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [taurine cattle]

Target Mutant/Chimera Details

GABA-A receptor [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

taurine cattle

Organs/Tissues

brain cortex

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

fluni

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.17

Deviation

0.200000

Measurement pX

8.66

Concomitants: Compound RN

754371; 4763661

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489 of 976

490 of 976

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p18508 + p63138

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Mutated:Substitution,1,Tyrosine,236,Glutamine + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flunitrazepam

Measurement Parameter

Kd

Unit

nM

Quantitative value

43

Deviation

6

Measurement pX

7.37

Concomitants: Compound RN

702691

Concomitants: Compound name

Flunitrazepam

Concomitants: Compound role

NSB

Target Name

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p18508 + p63138

Target PDB ID

2pr9

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491 of 976

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Mutated:Substitution,1,Tyrosine,236,Glutamine + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flunitrazepam

Measurement Parameter

Bmax

Unit

fmol/mg protein

Qualitative value

#

Quantitative value

400

Concomitants: Compound RN

702691

Concomitants: Compound name

Flunitrazepam

Concomitants: Compound role

NSB

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Bioassay : oocytes expressing human α3, α1 and α2L GABAA receptor subunits; effect of title comp. on pentobarbitone-, 5α-pregnan-3α-ol-20-one-, and propofolevoked currents mediated by the recombinant receptors in vitro; oocytes voltage-clamped at -60 mV; two-electrode voltage-clamp mode; continuously superfused (7-10 ml/min) with frog Ringer soln.; title comp., pentobarbitone, 5α-pregnan-3α-ol-20-one, and propofol applied by the superfusion system

Biological Species/NCBI ID

Xenopus laevis

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.300000 µM

Qualitative Results

title comp. enhanced responses to pentobarbitone, propofol, and 5α-pregnan-3α-ol-20-one

Measurement Parameter

Qualitative

Belelli, Delia; Callachan, Helen; Hill-Venning, Claire; Peters, John A.; Lambert, Jeremy J.; British Journal of Pharmacology; vol. 118; nb. 3; (1996); p. 563 - 576, View in Reaxys 492 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : cell membranes expressing human α1α3α2 GABAA receptorBioassay : membranes preincubated with 50 nmol/l des-methyl flunitrazepam for 30 min at 4 deg C and exposed to UV light (365 nm, 50-60 Hz, 200-220 V) for 1 h at 4 deg C; GABA: α-amino-

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butyric acid; BZ: benzodiazepine binding of <3H>title comp. to BZ binding site of GABAA receptor after photoincorporation of des-methyl flunitrazepam studied by saturation assay; incubation for 30 min at 20 deg C; radioactivity measured by scintillation counting Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.100000 nM

Qualitative Results

Bmax = 22.1 percent, Kd not detected (table)

Measurement Parameter

Qualitative

McKernan, Ruth M.; Farrar, Sophie; Collins, Ian; Emms, Frances; Asuni, Ayodeji; Quirk, Kathleen; Broughton, Howard; Molecular Pharmacology; vol. 54; nb. 1; (1998); p. 33 - 43, View in Reaxys 493 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : cell membranes expressing human α1α3α2 GABAA receptorBioassay : membranes preincubated with 50 nmol/l Ro 15-4513 (partial inverse agonist) for 30 min at 4 deg C and exposed to UV light (365 nm, 50-60 Hz, 200-220 V) for 1 h at 4 deg C; GABA: α-aminobutyric acid; BZ: benzodiazepine binding of <3H>title comp. to BZ binding site of GABAA receptor before and after photoincorporation of Ro 15-4513 studied by saturation assay; incubation for 30 min at 20 deg C; radioactivity measured by scintillation

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.100000 nM

Qualitative Results

binding of <3H>title comp. was reduced after photoincorporation of Ro 15-4513 by > 68 percent (Kd: 5.33 and 2.93 nmol/l, Bmax: 95.1 and 12.9 percent before and after photoincorporation, resp.) (figure, table)

Measurement Parameter

Qualitative

McKernan, Ruth M.; Farrar, Sophie; Collins, Ian; Emms, Frances; Asuni, Ayodeji; Quirk, Kathleen; Broughton, Howard; Molecular Pharmacology; vol. 54; nb. 1; (1998); p. 33 - 43, View in Reaxys 494 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : cell membranes expressing human α1α3α2 GABAA receptorBioassay : membranes preincubated with 50 nmol/l title comp. for 30 min at 4 deg C and exposed to UV light (365 nm, 50-60 Hz, 200-220 V) for 1 h at 4 deg C; GABA: α-aminobutyric acid; BZ: benzodiazepine affinity of title comp. to BZ binding site of GABAA receptor before and after photoincorporation of title comp. studied by competition assay using <3H>Ro 15-1788 as radioligand

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.300000 nM

Qualitative Results

Ki: 4.2 and 230.0 nmol/l before and after title comp. photoincorporation, resp. (table)

Measurement Parameter

Qualitative

McKernan, Ruth M.; Farrar, Sophie; Collins, Ian; Emms, Frances; Asuni, Ayodeji; Quirk, Kathleen; Broughton, Howard; Molecular Pharmacology; vol. 54; nb. 1; (1998); p. 33 - 43, View in Reaxys 495 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : cell membranes expressing human α1α3α2 GABAA receptorBioassay : membranes preincubated with 50 nmol/l title comp. for 30 min at 4 deg C and exposed to UV light (365 nm, 50-60 Hz, 200-220 V) for 1 h at 4 deg C; GABA: α-aminobutyric acid; BZ: benzodiazepine binding of <3H>title comp. to BZ binding site of GABAA receptor before and after photoincorporation of title comp. studied in presence of GABA (1 mmol/l)

Substance RN

702691View in Reaxys

Substance Name

31870

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Substance Dose

3 nM

Qualitative Results

binding of <3H>title comp. in presence of GABA: 156.3 percent before and no binding after title comp. photoincorporation resp. (table)

Measurement Parameter

Qualitative

McKernan, Ruth M.; Farrar, Sophie; Collins, Ian; Emms, Frances; Asuni, Ayodeji; Quirk, Kathleen; Broughton, Howard; Molecular Pharmacology; vol. 54; nb. 1; (1998); p. 33 - 43, View in Reaxys 496 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : cell membranes expressing human α1α3α2 GABAA receptorBioassay : membranes preincubated with 50 nmol/l title comp. (full agonist) for 30 min at 4 deg C and exposed to UV light (365 nm, 50-60 Hz, 200-220 V) for 1 h at 4 deg C; GABA: α-aminobutyric acid; BZ: benzodiazepine binding of <3H>title comp. to BZ binding site of GABAA receptor before and after photoincorporation of title comp. studied by saturation assay; incubation for 30 min at 20 deg C; radioactivity measured by scintillation counting

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.100000 nM

Qualitative Results

binding of <3H>title comp. was reduced after photoincorporation of title comp. by 84.1 percent (Kd: 5.33 and 6.06 nmol/l, Bmax: 95.1 and 9.4 percent before and after photoincorporation, resp.) (figure, table)

Measurement Parameter

Qualitative

McKernan, Ruth M.; Farrar, Sophie; Collins, Ian; Emms, Frances; Asuni, Ayodeji; Quirk, Kathleen; Broughton, Howard; Molecular Pharmacology; vol. 54; nb. 1; (1998); p. 33 - 43, View in Reaxys 497 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : cell membranes expressing human α1α3α2 GABAA receptorBioassay : GABA: α-aminobutyric acid; BZ: benzodiazepine affinity of title comp. for BZ binding site of GABAA receptor studied using radioligand <3H>title comp.

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.6

Measurement pX

8.59

McKernan, Ruth M.; Farrar, Sophie; Collins, Ian; Emms, Frances; Asuni, Ayodeji; Quirk, Kathleen; Broughton, Howard; Molecular Pharmacology; vol. 54; nb. 1; (1998); p. 33 - 43, View in Reaxys 498 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : cell membranes expressing human α1α3α2 GABAA receptorBioassay : GABA: α-aminobutyric acid; BZ:benzodiazepine affinity of title comp. for BZ binding site of GABAA receptor studied using radioligand <3H>CGS 8216

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

Ki

Unit

nM

Quantitative value

4.7

Measurement pX

8.33

McKernan, Ruth M.; Farrar, Sophie; Collins, Ian; Emms, Frances; Asuni, Ayodeji; Quirk, Kathleen; Broughton, Howard; Molecular Pharmacology; vol. 54; nb. 1; (1998); p. 33 - 43, View in Reaxys

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499 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : cell membranes expressing human α1α3α2 GABAA receptorBioassay : GABA: α-aminobutyric acid; BZ:benzodiazepine affinity of title comp. for BZ binding site of GABAA receptor studied using radioligand <3H>Ro 15-1788

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

Ki

Unit

nM

Quantitative value

5.9

Measurement pX

8.23

McKernan, Ruth M.; Farrar, Sophie; Collins, Ian; Emms, Frances; Asuni, Ayodeji; Quirk, Kathleen; Broughton, Howard; Molecular Pharmacology; vol. 54; nb. 1; (1998); p. 33 - 43, View in Reaxys 500 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : cell membranes expressing human α1α3α2 GABAA receptorBioassay : GABA: α-aminobutyric acid; BZ:benzodiazepine affinity of title comp. for BZ binding site of GABAA receptor studied using radioligand <3H>Ro 15-4513

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

Ki

Unit

nM

Quantitative value

3.2

Measurement pX

8.49

McKernan, Ruth M.; Farrar, Sophie; Collins, Ian; Emms, Frances; Asuni, Ayodeji; Quirk, Kathleen; Broughton, Howard; Molecular Pharmacology; vol. 54; nb. 1; (1998); p. 33 - 43, View in Reaxys 501 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : cell membranes expressing human α1α3α2 GABAA receptorBioassay : membranes preincubated with des-methyl, des-nitro flunitrazepam for 30 min at 4 deg C and exposed to UV light (365 nm, 50-60 Hz, 200-220 V) for 1 h at 4 deg C; GABA: α-aminobutyric acid; BZ: benzodiazepine binding of <3H>title comp. to BZ binding site of GABAA receptor after photoincorporation of des-methyl, des-nitro flunitrazepam studied by saturation assay; incubation for 30 min at 20 deg C; radioactivity measured by scintillation

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.100000 nM

Measurement Parameter

Kd

Unit

nM

Quantitative value

3.4

Measurement pX

8.47

McKernan, Ruth M.; Farrar, Sophie; Collins, Ian; Emms, Frances; Asuni, Ayodeji; Quirk, Kathleen; Broughton, Howard; Molecular Pharmacology; vol. 54; nb. 1; (1998); p. 33 - 43, View in Reaxys 502 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : cell membranes expressing human α1α3α2 GABAA receptorBioassay : membranes preincubated with 500 nmol/l chlordiazepoxide for 30 min at 4 deg C and exposed to UV light (365 nm, 50-60 Hz, 200-220 V) for 1 h at 4 deg C; GABA: α-aminobutyric acid; BZ: benzodiazepine binding of <3H>title comp. to BZ binding site of GABAA receptor after

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photoincorporation of chlordiazepoxide studied by saturation assay; incubation for 30 min at 20 deg C; radioactivity measured by scintillation counting Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.100000 nM

Measurement Parameter

Kd

Unit

nM

Quantitative value

4.3

Measurement pX

8.37

McKernan, Ruth M.; Farrar, Sophie; Collins, Ian; Emms, Frances; Asuni, Ayodeji; Quirk, Kathleen; Broughton, Howard; Molecular Pharmacology; vol. 54; nb. 1; (1998); p. 33 - 43, View in Reaxys 503 of 976

504 of 976

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

CD rat

Organs/Tissues

brain

Cells/Cell Lines

cells

Cell Fraction

Synaptosome: membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

360 nM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

100

Measurement pX

7.72

Concomitants: Compound RN

754371; 759557

Concomitants: Compound name

[3H]-Diazepam; Clonazepam

Concomitants: Compound role

RAD; NSB

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

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505 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

CD rat

Organs/Tissues

brain

Cells/Cell Lines

cells

Cell Fraction

Synaptosome: membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.0360000 nM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

21.7

Measurement pX

1

Concomitants: Compound RN

754371; 759557

Concomitants: Compound name

[3H]-Diazepam; Clonazepam

Concomitants: Compound role

RAD; NSB

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

CD rat

Organs/Tissues

brain

Cells/Cell Lines

cells

Cell Fraction

Synaptosome: membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.360000 nM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

45.9

Measurement pX

9.37

Concomitants: Compound RN

754371; 759557

Concomitants: Compound name

[3H]-Diazepam; Clonazepam

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506 of 976

507 of 976

Concomitants: Compound role

RAD; NSB

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

CD rat

Organs/Tissues

brain

Cells/Cell Lines

cells

Cell Fraction

Synaptosome: membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

3.60000 nM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

86.3

Measurement pX

9.24

Concomitants: Compound RN

754371; 759557

Concomitants: Compound name

[3H]-Diazepam; Clonazepam

Concomitants: Compound role

RAD; NSB

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

CD rat

Organs/Tissues

brain

Cells/Cell Lines

cells

Cell Fraction

Synaptosome: membrane

Substance RN

702691View in Reaxys

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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508 of 976

509 of 976

Substance Name

Flunitrazepam

Substance Dose

36 nM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

98.8

Measurement pX

8.72

Concomitants: Compound RN

754371; 759557

Concomitants: Compound name

[3H]-Diazepam; Clonazepam

Concomitants: Compound role

RAD; NSB

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

CD rat

Organs/Tissues

brain

Cells/Cell Lines

cells

Cell Fraction

Synaptosome: membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

IC50

Unit

nM

Quantitative value

0.688

Measurement pX

9.16

Concomitants: Compound RN

754371; 759557

Concomitants: Compound name

[3H]-Diazepam; Clonazepam

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p28472 + p18507 + p14867

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

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510 of 976

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1.00000E-09 M

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.2

Measurement pX

8.66

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-2 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-2; gabra2; gamma-aminobutyric acid receptor subunit alpha-2

Target Uniprot ID

p28472 + p18507 + p47869

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-2 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-2 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1.00000E-09 M

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.5

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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511 of 976

512 of 976

Measurement pX

8.6

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-3 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p28472 + p18507 + p34903

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-3 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1.00000E-09 M

Measurement Parameter

Ki

Unit

nM

Quantitative value

4.5

Measurement pX

8.35

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-5 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5

Target Uniprot ID

p28472 + p18507 + p31644

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-5 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

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513 of 976

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-5 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1.00000E-09 M

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.1

Measurement pX

8.68

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-6 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-6; gabra6; gamma-aminobutyric acid receptor subunit alpha-6

Target Uniprot ID

p28472 + p18507 + q16445

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-6 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-6 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1.00000E-09 M

Measurement Parameter

Ki

Unit

nM

Qualitative value

>

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514 of 976

515 of 976

Quantitative value

2000

Measurement pX

5.7

Concomitants: Compound RN

754371; 6182319

Concomitants: Compound name

Diazepam; [3H]-Ro 15-4513

Concomitants: Compound role

NSB; RAD

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Sprague Dawley rat

Organs/Tissues

brain cortex

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

IC50

Unit

nM

Quantitative value

3

Measurement pX

8.52

Concomitants: Compound RN

702691; 702691

Concomitants: Compound name

Flunitrazepam; [3H]-Flunitrazepam

Concomitants: Compound role

NSB; RAD

Bioassay Category

Metabolism/Transport

Bioassay Name

Binding

Biological Species/NCBI ID

human

Organs/Tissues

plasma

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

fu

Quantitative value

0.21

Votano, Joseph R.; Parham, Marc; Hall, L. Mark; Hall, Lowell H.; Kier, Lemont B.; Oloff, Scott; Tropsha, Alexander; Journal of Medicinal Chemistry; vol. 49; nb. 24; (2006); p. 7169 - 7181, View in Reaxys 516 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor blocking agent Target : Xenopus laevis oocyte, transfectedBioassay : oocyte expressed GABAA receptors composed of α1, α2, α1 subunits; GABA conc. (3-8 μmol/l) corresponded to conc. eliciting 5-10 percent of maximal current amplitude (EC5-10); control: sol. contained GABA without title comp. chamber with oocyte perfused with sol. contained GABA (3-8 μmol/l or 1 mmol/l) and title comp. by fast perfusion system; GABA-induced chloride currents (IGABA) measured by two-electrode voltage-clamp

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1 µM

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Qualitative Results

title comp. inhibited IGABA (11 percent at 1 μmol/l); at GABA conc. 1 mmol/l title comp. did not affect IGABA

Measurement Parameter

Qualitative

Khom; Baburin; Timin; Hohaus; Sieghart; Hering; Molecular Pharmacology; vol. 69; nb. 2; (2006); p. 640 - 649, View in Reaxys 517 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor blocking agent Target : Xenopus laevis oocyte, transfectedBioassay : oocyte expressed GABAA receptors composed of α1, α2 subunits; GABA conc. (3-8 μmol/l) corresponded to conc. eliciting 5-10 percent of maximal current amplitude (EC5-10); control: sol. contained GABA without title comp. chamber with oocyte perfused with sol. contained GABA (3-8 μmol/l) and title comp. by fast perfusion system; GABA-induced chloride currents (IGABA) measured by two-electrode voltage-clamp method at holding potential

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1 µM

Qualitative Results

title comp. did not inhibit IGABA statistically significant (9 percent)

Measurement Parameter

Qualitative

Khom; Baburin; Timin; Hohaus; Sieghart; Hering; Molecular Pharmacology; vol. 69; nb. 2; (2006); p. 640 - 649, View in Reaxys 518 of 976

519 of 976

Target Name

UDP-glucuronosyltransferase 2B7*2 [human]

Target Synonyms

udp-glucuronosyltransferase 2b7*2

Target, Subunit, Species

UDP-glucuronosyltransferase 2B7*2 [human]

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 2B7*2 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

µM

Quantitative value

52

Measurement pX

4.28

Metabolite RN

24366853

Metabolite name

4-Hydroxyestrone 4-O-glucuronide

Concomitants: Compound RN

2221832; 78881; 85594; 8188580; 506008

Concomitants: Compound name

4-Hydroxy-Estrone; Uridine 5'-diphosphoglucuronic acid; Saccharo-1,4-lactone; Phosphatidylcholine; DMSO

Concomitants: Compound role

SUB; COM; COM; COM; SLV

Target Name

UDP-glucuronosyltransferase 2B7*2 [human]

Target Synonyms

udp-glucuronosyltransferase 2b7*2

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520 of 976

Target, Subunit, Species

UDP-glucuronosyltransferase 2B7*2 [human]

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 2B7*2 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

µM

Quantitative value

61

Measurement pX

4.21

Metabolite RN

24400694

Metabolite name

4-Hydroxyestradiol 4-O-glucuronide

Concomitants: Compound RN

2219366; 78881; 85594; 8188580; 506008

Concomitants: Compound name

4-Hydroxyestradiol; Uridine 5'-diphosphoglucuronic acid; Saccharo-1,4-lactone; Phosphatidylcholine; DMSO

Concomitants: Compound role

SUB; COM; COM; COM; SLV

Target Name

UDP-glucuronosyltransferase 2B7*2 [human]

Target Synonyms

udp-glucuronosyltransferase 2b7*2

Target, Subunit, Species

UDP-glucuronosyltransferase 2B7*2 [human]

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 2B7*2 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

µM

Quantitative value

47

Measurement pX

4.33

Metabolite RN

4944536

Metabolite name

Nalorphine glucuronide

Concomitants: Compound RN

78881; 85594; 8188580; 506008; 50597

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521 of 976

522 of 976

Concomitants: Compound name

Uridine 5'-diphosphoglucuronic acid; Saccharo-1,4-lactone; Phosphatidylcholine; DMSO; Nalorphine

Concomitants: Compound role

COM; COM; COM; SLV; SUB

Target Name

UDP-glucuronosyltransferase 2B7*2 [human]

Target Synonyms

udp-glucuronosyltransferase 2b7*2

Target, Subunit, Species

UDP-glucuronosyltransferase 2B7*2 [human]

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 2B7*2 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

µM

Quantitative value

93

Measurement pX

4.03

Metabolite RN

10411102

Metabolite name

Buprenorphine 3-O-glucuronide

Concomitants: Compound RN

78881; 85594; 8188580; 6182863; 506008

Concomitants: Compound name

Uridine 5'-diphosphoglucuronic acid; Saccharo-1,4-lactone; Phosphatidylcholine; Buprenorphine; DMSO

Concomitants: Compound role

COM; COM; COM; SUB; SLV

Target Name

UDP-glucuronosyltransferase 1-1 [human]

Target Synonyms

bilirubin-specific udpgt isozyme 1; gnt1; hug-br1; udp-glucuronosyltransferase 1-1; udp-glucuronosyltransferase 1-a; udp-glucuronosyltransferase 1a1; udpgt 1-1; ugt-1a; ugt1; ugt1*1; ugt1-01; ugt1.1; ugt1a; ugt1a1

Target Uniprot ID

p22309

Target, Subunit, Species

UDP-glucuronosyltransferase 1-1 [human]

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 1-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

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523 of 976

524 of 976

Measurement Parameter

Ki

Unit

µM

Quantitative value

206

Measurement pX

3.69

Metabolite RN

10411102

Metabolite name

Buprenorphine 3-O-glucuronide

Concomitants: Compound RN

78881; 85594; 8188580; 6182863; 506008

Concomitants: Compound name

Uridine 5'-diphosphoglucuronic acid; Saccharo-1,4-lactone; Phosphatidylcholine; Buprenorphine; DMSO

Concomitants: Compound role

COM; COM; COM; SUB; SLV

Target Name

UDP-glucuronosyltransferase 1-1 [human]

Target Synonyms

bilirubin-specific udpgt isozyme 1; gnt1; hug-br1; udp-glucuronosyltransferase 1-1; udp-glucuronosyltransferase 1-a; udp-glucuronosyltransferase 1a1; udpgt 1-1; ugt-1a; ugt1; ugt1*1; ugt1-01; ugt1.1; ugt1a; ugt1a1

Target Uniprot ID

p22309

Target, Subunit, Species

UDP-glucuronosyltransferase 1-1 [human]

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 1-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

µM

Quantitative value

808

Measurement pX

3.09

Metabolite RN

11305843

Metabolite name

2-Hydroxyestrone 2-O-glucuronide

Concomitants: Compound RN

2221833; 78881; 85594; 8188580; 506008

Concomitants: Compound name

2-Hydroxy-Estrone; Uridine 5'-diphosphoglucuronic acid; Saccharo-1,4-lactone; Phosphatidylcholine; DMSO

Concomitants: Compound role

SUB; COM; COM; COM; SLV

Target Name

UDP-glucuronosyltransferase 1-1 [human]

Target Synonyms

bilirubin-specific udpgt isozyme 1; gnt1; hug-br1; udp-glucuronosyltransferase 1-1; udp-glucuronosyltransferase 1-a; udp-glucuronosyltransferase 1a1; udpgt 1-1; ugt-1a; ugt1; ugt1*1; ugt1-01; ugt1.1; ugt1a; ugt1a1

Target Uniprot ID

p22309

Target, Subunit, Species

UDP-glucuronosyltransferase 1-1 [human]

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525 of 976

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 1-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

µM

Quantitative value

402

Measurement pX

3.4

Metabolite RN

11305843

Metabolite name

2-Hydroxyestrone 2-O-glucuronide

Concomitants: Compound RN

2219367; 78881; 85594; 8188580; 506008

Concomitants: Compound name

2-Hydroxyestradiol; Uridine 5'-diphosphoglucuronic acid; Saccharo-1,4-lactone; Phosphatidylcholine; DMSO

Concomitants: Compound role

SUB; COM; COM; COM; SLV

Target Name

UDP-glucuronosyltransferase 1-3 [human]

Target Synonyms

gnt1; udp-glucuronosyltransferase 1-3; udp-glucuronosyltransferase 1-c; udp-glucuronosyltransferase 1a3; udpgt 1-3; ugt-1c; ugt1; ugt1*3; ugt1-03; ugt1.3; ugt1a3; ugt1c

Target Uniprot ID

p35503

Target, Subunit, Species

UDP-glucuronosyltransferase 1-3 [human]

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 1-3 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Homogenate

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Qualitative value

NA

Measurement pX

1

Metabolite RN

10411102

Metabolite name

Buprenorphine 3-O-glucuronide

Concomitants: Compound RN

78881; 85594; 8188580; 6182863; 506008

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526 of 976

527 of 976

Concomitants: Compound name

Uridine 5'-diphosphoglucuronic acid; Saccharo-1,4-lactone; Phosphatidylcholine; Buprenorphine; DMSO

Concomitants: Compound role

COM; COM; COM; SUB; SLV

Target Name

UDP-glucuronosyltransferase 1-3 [human]

Target Synonyms

gnt1; udp-glucuronosyltransferase 1-3; udp-glucuronosyltransferase 1-c; udp-glucuronosyltransferase 1a3; udpgt 1-3; ugt-1c; ugt1; ugt1*3; ugt1-03; ugt1.3; ugt1a3; ugt1c

Target Uniprot ID

p35503

Target, Subunit, Species

UDP-glucuronosyltransferase 1-3 [human]

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 1-3 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Homogenate

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

µM

Quantitative value

22

Measurement pX

4.66

Metabolite RN

11305843

Metabolite name

2-Hydroxyestrone 2-O-glucuronide

Concomitants: Compound RN

2221833; 78881; 85594; 8188580; 506008

Concomitants: Compound name

2-Hydroxy-Estrone; Uridine 5'-diphosphoglucuronic acid; Saccharo-1,4-lactone; Phosphatidylcholine; DMSO

Concomitants: Compound role

SUB; COM; COM; COM; SLV

Target Name

UDP-glucuronosyltransferase 1-3 [human]

Target Synonyms

gnt1; udp-glucuronosyltransferase 1-3; udp-glucuronosyltransferase 1-c; udp-glucuronosyltransferase 1a3; udpgt 1-3; ugt-1c; ugt1; ugt1*3; ugt1-03; ugt1.3; ugt1a3; ugt1c

Target Uniprot ID

p35503

Target, Subunit, Species

UDP-glucuronosyltransferase 1-3 [human]

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 1-3 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Homogenate

Substance RN

702691View in Reaxys

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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528 of 976

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

µM

Quantitative value

30

Measurement pX

4.52

Metabolite RN

11305843

Metabolite name

2-Hydroxyestrone 2-O-glucuronide

Concomitants: Compound RN

2219367; 78881; 85594; 8188580; 506008

Concomitants: Compound name

2-Hydroxyestradiol; Uridine 5'-diphosphoglucuronic acid; Saccharo-1,4-lactone; Phosphatidylcholine; DMSO

Concomitants: Compound role

SUB; COM; COM; COM; SLV

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |drug dependence Bioassay : simple experimental epidemiologic survey of prescription forgeries in community pharmacies (1253 pharmacies) in the Midi-Pyrenees area (southwest France)

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

17 percent of the all forged prescription was made to obtain title compound

Measurement Parameter

Qualitative

Lapeyre-Mestre; Damase-Michel; Adams; Michaud; Montastruc; European Journal of Clinical Pharmacology; vol. 52; nb. 1; (1997); p. 37 - 39, View in Reaxys 529 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : receptor binding affinityTarget : astrocytoma A172 cell membranesBioassay : membrane fragments immobilized on IAM chromatographic phase

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

molecular target: α-aminobutyric acid receptor

Measurement Parameter

Qualitative

Kitabatake; Moaddel; Cole; Gandhari; Frazier; Hartenstein; Rosenberg; Bernier; Wainer; Analytical Chemistry; vol. 80; nb. 22; (2008); p. 8673 - 8680, View in Reaxys 530 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : receptor binding affinityTarget : astrocytoma 1321N1 cell membranes of humanBioassay : membrane fragments immobilized on IAM chromatographic phase

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

molecular target: α-aminobutyric acid receptor

Measurement Parameter

Qualitative

Kitabatake; Moaddel; Cole; Gandhari; Frazier; Hartenstein; Rosenberg; Bernier; Wainer; Analytical Chemistry; vol. 80; nb. 22; (2008); p. 8673 - 8680, View in Reaxys 531 of 976

Bioassay Category

In Vitro (Efficacy)

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Bioassay Name

In Vitro (others)

Bioassay Details

Effect : receptor binding affinityTarget : astrocytoma A172 cell membranesBioassay : membrane fragments immobilized on IAM chromatographic phase; dissociation constant (Kd)

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

Kd

Unit

nM

Quantitative value

0.81

Measurement pX

9.09

Kitabatake; Moaddel; Cole; Gandhari; Frazier; Hartenstein; Rosenberg; Bernier; Wainer; Analytical Chemistry; vol. 80; nb. 22; (2008); p. 8673 - 8680, View in Reaxys 532 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : receptor binding affinityTarget : astrocytoma 1321N1 cell membranes of humanBioassay : membrane fragments immobilized on IAM chromatographic phase; dissociation constant (Kd)

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

Kd

Unit

nM

Quantitative value

1.05

Measurement pX

8.98

Kitabatake; Moaddel; Cole; Gandhari; Frazier; Hartenstein; Rosenberg; Bernier; Wainer; Analytical Chemistry; vol. 80; nb. 22; (2008); p. 8673 - 8680, View in Reaxys 533 of 976

Target Name

Ionotropic gamma aminobutyric acid receptor [Rattus norvegicus]

Target Synonyms

ionotropic gamma aminobutyric acid receptor

Target, Subunit, Species

Ionotropic gamma aminobutyric acid receptor [Rattus norvegicus]

Target Mutant/Chimera Details

Ionotropic gamma aminobutyric acid receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Sprague Dawley rat

Organs/Tissues

brain cortex

Cells/Cell Lines

cells

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flunitrazepam

Measurement Parameter

Kd

Unit

nM

Quantitative value

1.3

Deviation

0.200000

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Measurement pX

8.89

Concomitants: Compound RN

759557

Concomitants: Compound name

Clonazepam

Concomitants: Compound role

NSB

Target Name

Ionotropic gamma aminobutyric acid receptor [Rattus norvegicus]

Target Synonyms

ionotropic gamma aminobutyric acid receptor

Target, Subunit, Species

Ionotropic gamma aminobutyric acid receptor [Rattus norvegicus]

Target Mutant/Chimera Details

Ionotropic gamma aminobutyric acid receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Sprague Dawley rat

Organs/Tissues

brain cortex

Cells/Cell Lines

cells

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]-Flunitrazepam

Measurement Parameter

Bmax

Unit

pmol/mg protein

Quantitative value

0.84

Deviation

0.0500000

Concomitants: Compound RN

759557

Concomitants: Compound name

Clonazepam

Concomitants: Compound role

NSB

Target Name

Gamma hydroxybutyric acid receptor [Rattus norvegicus]

Target Synonyms

gamma hydroxybutyric acid receptor

Target, Subunit, Species

Gamma hydroxybutyric acid receptor [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma hydroxybutyric acid receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Sprague Dawley rat

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536 of 976

537 of 976

Organs/Tissues

brain cortex

Cells/Cell Lines

cells

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

10 µM

Measurement Parameter

% Inhibition

Qualitative value

NA

Measurement pX

1

Concomitants: Compound RN

24175947; 24175947

Concomitants: Compound name

NCS-382; [3H]-NCS-382

Concomitants: Compound role

NSB; RAD

Target Name

Gamma hydroxybutyric acid receptor [Rattus norvegicus]

Target Synonyms

gamma hydroxybutyric acid receptor

Target, Subunit, Species

Gamma hydroxybutyric acid receptor [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma hydroxybutyric acid receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Sprague Dawley rat

Organs/Tissues

brain cortex

Cells/Cell Lines

cells

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

10 µM

Measurement Parameter

%

Measurement Object

stimulated binding

Qualitative value

NA

Measurement pX

1

Concomitants: Compound RN

24175947; 24175947

Concomitants: Compound name

NCS-382; [3H]-NCS-382

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit alpha-6 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

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Target Synonyms

gaba(a) receptor subunit alpha-6; gabra-6; gabra6; gamma-aminobutyric acid receptor subunit alpha-6 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2

Target Uniprot ID

p30191 + p18508 + p63138

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-6 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-6 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Qualitative value

>

Quantitative value

10000

Measurement pX

1

Concomitants: Compound RN

6182319

Concomitants: Compound name

[3H]-Ro 15-4513

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit alpha-4 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit delta [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit alpha-4; gabra4; gamma-aminobutyric acid receptor subunit alpha-4 + gaba(a) receptor subunit beta-3; gabrb-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta

Target Uniprot ID

p28471 + p63079 + p18506

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-4 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit delta [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-4 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit delta [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

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Cells/Cell Lines

HEK293T cell line

Substance RN

702691View in Reaxys

Substance Name

FLUNITRAZEPAM

Measurement Parameter

Ki

Unit

nM

Qualitative value

>>

Quantitative value

1000

Measurement pX

6

Concomitants: Compound RN

6182319

Concomitants: Compound name

[3H]-Ro 15-4513

Concomitants: Compound role

RAD

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : formula Ia metabolite formation; effect onTarget : liver cytosol of humanBioassay : Inhibition Studies with AKR Competitors Inhibition studies were also conducted using some of the AKR competitors listed in Table 2.; Note that AKR1C2/3 inhibitor 5beta-cholanic acid 3alpha, 7-alphadiol, a bile acid displayed IC50s of 0.21 um and 74.4 uM for AKR1C2 and AKR1C3, respectively, using tibolone

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

title compound at 60µM inhibited metabolism of 14C-radiolabelled compound of Formula Ia by 51%

Measurement Parameter

Qualitative

Patent; Ghosal, Anima; Kishnani, Narendra S.; Alton, Kevin B.; White, Ronald E.; US2006/276404; (2006); (A1) English, View in Reaxys 540 of 976

Target Name

UDP-glucuronosyltransferase 2B7 [human]

Target Synonyms

3,4-catechol estrogen-specific udpgt; udp-glucuronosyltransferase 2b7; udp-glucuronosyltransferase 2b9; udpgt 2b7; udpgt 2b9; udpgth-2; ugt2b7; ugtb2b9

Target Uniprot ID

p16662

Target PDB ID

2o6l

Target, Subunit, Species

UDP-glucuronosyltransferase 2B7 [human]

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 2B7 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

µM

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541 of 976

542 of 976

Measurement Object

ALL

Quantitative value

25

Measurement pX

4.6

Concomitants: Compound RN

78881; 85594; 93704

Concomitants: Compound name

[14C]-Uridine 5'-diphosphoglucuronic acid; Saccharo-1,4-lactone; Morphine

Concomitants: Compound role

MAR; COM; SUB

Target Name

UDP-glucuronosyltransferase 2B7 [human]

Target Synonyms

3,4-catechol estrogen-specific udpgt; udp-glucuronosyltransferase 2b7; udp-glucuronosyltransferase 2b9; udpgt 2b7; udpgt 2b9; udpgth-2; ugt2b7; ugtb2b9

Target Uniprot ID

p16662

Target PDB ID

2o6l

Target, Subunit, Species

UDP-glucuronosyltransferase 2B7 [human]

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 2B7 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

µM

Measurement Object

ALL

Quantitative value

31

Measurement pX

4.51

Concomitants: Compound RN

3595791; 78881; 85594

Concomitants: Compound name

[14C]-Zidovudine; Uridine 5'-diphosphoglucuronic acid; Saccharo-1,4-lactone

Concomitants: Compound role

SUB; COM; COM

Target Name

Serum albumin [human]

Target Synonyms

alb; serum albumin

Target Uniprot ID

p02768

Target PDB ID

1ao6; 1bj5; 1bke; 1bm0; 1e78; 1e7a; 1e7b; 1e7c; 1e7e; 1e7f; 1e7g; 1e7h; 1e7i; 1gni; 1gnj; 1h9z; 1ha2; 1hk1; 1hk2; 1hk3; 1hk4; 1hk5; 1n5u; 1o9x; 1tf0; 1uor; 1ysx; 2bx8; 2bxa; 2bxb; 2bxc; 2bxd; 2bxe; 2bxf; 2bxg; 2bxh; 2bxi; 2bxk; 2bxl; 2bxm; 2bxn; 2bxo; 2bxp; 2bxq; 2esg; 2i2z; 2i30; 2n0x; 2vdb; 2vue; 2vuf; 2xsi; 2xvq; 2xvu; 2xvv; 2xvw; 2xw0; 2xw1; 2ydf; 3a73; 3b9l; 3b9m; 3cx9; 3jqz; 3jry; 3lu6; 3lu7; 3lu8; 3sqj; 3tdl; 3uiv; 4bke; 4e99; 4emx; 4g03; 4g04; 4hgk; 4hgm; 4iw1; 4iw2; 4k2c; 4k71; 4l8u; 4l9k; 4l9q; 4la0; 4lb2; 4lb9; 4n0f; 4n0u; 4s1y; 4z69; 5fuo; 5id7; 5ifo; 5ijf; 5ujb; 5x52

Target, Subunit, Species

Serum albumin [human]

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Target Mutant/Chimera Details

Serum albumin [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : human serum albumin; binding ofBioassay : TRANSIL® technology

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

LogHSA -3.046 no_unit

Measurement Parameter

Qualitative

Quantitative value

-3.046

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

inhibitory influence on respiration in anesthetized cats (chloralose/urethane and pentobarbital anesthesia), 0.005-3.325 mg/kg i.v. administration

Measurement Parameter

Qualitative

Danneberg; Arzneimittel-Forschung/Drug Research; vol. 36; nb. 3 A; (1986); p. 610 - 615, View in Reaxys 544 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

in vitro central nervous system receptors binding affinities: <3H>flunitrazepam (benzodiazepine receptor) pIC50= 8.30 in male rat cerebral cortices

Measurement Parameter

Qualitative

Nicholls, Ian A.; Alewood, Paul F.; Brinkworth, Ross I.; Morrison, Stuart F.; Andrews, Peter R.; Journal of Chemical Research, Miniprint; nb. 10; (1993); p. 2811 - 2826, View in Reaxys 545 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

effect of cumulative concentrations on peripheral neuromuscular function (in-vitro rat phrenic nerve-hemidiaphragm preparation)

Measurement Parameter

Qualitative

Driessen; Vree; Booij; et al.; Journal of Pharmacy and Pharmacology; vol. 36; nb. 4; (1984); p. 244 - 247, View in Reaxys 546 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

inhibition of specific 3H-flunitrazepam binding in in vitro preparations of rat cerebral cortex memranes at O deg C; IC50 3.0 nM

Measurement Parameter

Qualitative

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Dodd, Robert H.; Doisy, Xavier; Potier, Pierre; Potier, Marie-Claude; Rossier, Jean; Heterocycles; vol. 28; nb. 2; (1989); p. 1101 - 1113, View in Reaxys 547 of 976

Substance Effect

Psychotropic

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Bioassay Details

Effect : (3)H-flunitrazepam bindingTarget : Wistar rat synaptosomesBioassay : amount of (3)H-flunitrazepam receptors (Bmax); dissociation constant (Kd) of ligand-receptor complex synaptosomes isol. from brain of male Wistar rats weighing 150-200 g; label. test comp.; in the pres. and abs. of TMD; 22 deg C; radioact. meas. on a Beat-1 liquid. scint. counter

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

Bmax: 30.0-31.5 fM/mg protein in the pres. and abs. of TMD; Kd: 2.27-7.14 pM/mg protein in the pres. and abs. of TMD; IC50 of (3)H-imipramine in the pres. of TMD 0.53 mM

Measurement Parameter

Qualitative

Stradomskii; Klimontova; Ryabukhin; Pharmaceutical Chemistry Journal; vol. 31; nb. 1; (1997); p. 7 - 8, View in Reaxys 548 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |agonist Target : Xenopus laevis oocytes expressing human GABAA receptorBioassay : GABA: α-aminobutyric acid; 5α3α: 5α-pregnan-3α-ol-20-one electrical recordings made from oocytes expressing human α1α1α2L GABAA receptors; oocytes voltage-clamped at -60 mV in two-electrode voltage clamp mode; current induced by propofol, sodium pentobarbitone, 5α3α and trichloroethanol

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.300000 µM

Qualitative Results

title comp. potentiated propofol-, pentobarbitone- and 5α3α-induced inward currents

Measurement Parameter

Qualitative

Pistis, Marco; Belelli, Delia; Peters, John A.; Lambert, Jeremy J.; British Journal of Pharmacology; vol. 122; nb. 8; (1997); p. 1707 - 1719, View in Reaxys 549 of 976

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Effect : exposureBioassay : accordance between data sources, reliability 1136 subjects age >65 years: 318 cases (hip fractures), 818 control; 276 men (mean age 79 years), 860 women (81); data sources: patient questionnaire, medical records, plasma samples (HPLC)

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Route of Adm.

oral administration

Qualitative Results

concordance between questionnaires or medical records and plasma samples (table)

Measurement Parameter

Qualitative

Moore; Pierfitte; Pehourcq; Lagnaoui; Begaud; Clinical Pharmacology and Therapeutics; vol. 69; nb. 6; (2001); p. 445 - 450, View in Reaxys 550 of 976

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p28472 + p18507 + p14867

Target PDB ID

4cof

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551 of 976

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Substance RN

702691View in Reaxys

Substance Name

146

Substance Dose

1.00000E-09 M

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.2

Measurement pX

8.66

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-2 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-2; gabra2; gamma-aminobutyric acid receptor subunit alpha-2

Target Uniprot ID

p28472 + p18507 + p47869

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-2 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-2 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Substance RN

702691View in Reaxys

Substance Name

146

Substance Dose

1.00000E-09 M

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.5

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553 of 976

Measurement pX

8.6

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-3 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit alpha-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p28472 + p18507 + p34903

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-3 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Substance RN

702691View in Reaxys

Substance Name

146

Substance Dose

1.00000E-09 M

Measurement Parameter

Ki

Unit

nM

Quantitative value

4.5

Measurement pX

8.35

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit alpha-5 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2

Target Uniprot ID

p28472 + p31644 + p18507

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-5 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-5 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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554 of 976

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Substance RN

702691View in Reaxys

Substance Name

146

Substance Dose

1.00000E-09 M

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.1

Measurement pX

8.68

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit alpha-6 [human];+Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-6; gabra6; gamma-aminobutyric acid receptor subunit alpha-6 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2

Target Uniprot ID

p28472 + q16445 + p18507

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-6 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-6 [human]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Substance RN

702691View in Reaxys

Substance Name

146

Substance Dose

1.00000E-09 M

Measurement Parameter

Ki

Unit

nM

Qualitative value

>

Quantitative value

2000

Measurement pX

5.7

Concomitants: Compound RN

754371; 6182319

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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555 of 976

Concomitants: Compound name

Diazepam; [3H]-Ro 15-4513

Concomitants: Compound role

NSB; RAD

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

Human Caucasian

Population State

Healthy

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

t1/2 abs

Unit

hour

Quantitative value

0.144

Boxenbaum; Posmanter; Macasieb; Geitner; Weinfeld; Moore; Darragh; O'Kelly; Weissman; Kaplan; Journal of Pharmacokinetics and Biopharmaceutics; vol. 6; nb. 4; (1978); p. 283 - 293, View in Reaxys 556 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

Human Caucasian

Population State

Healthy

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Tlag

Unit

hour

Quantitative value

0.266

Boxenbaum; Posmanter; Macasieb; Geitner; Weinfeld; Moore; Darragh; O'Kelly; Weissman; Kaplan; Journal of Pharmacokinetics and Biopharmaceutics; vol. 6; nb. 4; (1978); p. 283 - 293, View in Reaxys 557 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

Human Caucasian

Population State

Healthy

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg

Substance Route of Adm.

oral administration

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Substance Dosing Regimen

Single

Measurement Parameter

t1/2 [lambda1]

Unit

hour

Quantitative value

2.07

Boxenbaum; Posmanter; Macasieb; Geitner; Weinfeld; Moore; Darragh; O'Kelly; Weissman; Kaplan; Journal of Pharmacokinetics and Biopharmaceutics; vol. 6; nb. 4; (1978); p. 283 - 293, View in Reaxys 558 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

Human Caucasian

Population State

Healthy

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

t1/2 el

Unit

hour

Quantitative value

13.5

Boxenbaum; Posmanter; Macasieb; Geitner; Weinfeld; Moore; Darragh; O'Kelly; Weissman; Kaplan; Journal of Pharmacokinetics and Biopharmaceutics; vol. 6; nb. 4; (1978); p. 283 - 293, View in Reaxys 559 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

Human Caucasian

Population State

Healthy

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Cl/F

Unit

L/h/kg

Quantitative value

0.278

Boxenbaum; Posmanter; Macasieb; Geitner; Weinfeld; Moore; Darragh; O'Kelly; Weissman; Kaplan; Journal of Pharmacokinetics and Biopharmaceutics; vol. 6; nb. 4; (1978); p. 283 - 293, View in Reaxys 560 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

Human Caucasian

Population State

Healthy

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

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Substance Dose

2 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Vd ss/F

Unit

L/kg

Quantitative value

4.44

Boxenbaum; Posmanter; Macasieb; Geitner; Weinfeld; Moore; Darragh; O'Kelly; Weissman; Kaplan; Journal of Pharmacokinetics and Biopharmaceutics; vol. 6; nb. 4; (1978); p. 283 - 293, View in Reaxys 561 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

Human Caucasian

Population State

Healthy

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Blood/Serum ratio

Quantitative value

0.75

Boxenbaum; Posmanter; Macasieb; Geitner; Weinfeld; Moore; Darragh; O'Kelly; Weissman; Kaplan; Journal of Pharmacokinetics and Biopharmaceutics; vol. 6; nb. 4; (1978); p. 283 - 293, View in Reaxys 562 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

Human Caucasian

Population State

Healthy

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Repeated

Measurement Parameter

t1/2 abs

Unit

hour

Quantitative value

1.47

Boxenbaum; Posmanter; Macasieb; Geitner; Weinfeld; Moore; Darragh; O'Kelly; Weissman; Kaplan; Journal of Pharmacokinetics and Biopharmaceutics; vol. 6; nb. 4; (1978); p. 283 - 293, View in Reaxys 563 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

Human Caucasian

Population State

Healthy

Substance RN

702691View in Reaxys

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Substance Name

Flunitrazepam

Substance Dose

2 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Repeated

Measurement Parameter

t1/2 [lambda1]

Unit

hour

Quantitative value

1.9

Boxenbaum; Posmanter; Macasieb; Geitner; Weinfeld; Moore; Darragh; O'Kelly; Weissman; Kaplan; Journal of Pharmacokinetics and Biopharmaceutics; vol. 6; nb. 4; (1978); p. 283 - 293, View in Reaxys 564 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

Human Caucasian

Population State

Healthy

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Repeated

Measurement Parameter

t1/2 el

Unit

hour

Quantitative value

19.2

Boxenbaum; Posmanter; Macasieb; Geitner; Weinfeld; Moore; Darragh; O'Kelly; Weissman; Kaplan; Journal of Pharmacokinetics and Biopharmaceutics; vol. 6; nb. 4; (1978); p. 283 - 293, View in Reaxys 565 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

Human Caucasian

Population State

Healthy

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Repeated

Measurement Parameter

Cl/F

Unit

L/h/kg

Quantitative value

0.278

Boxenbaum; Posmanter; Macasieb; Geitner; Weinfeld; Moore; Darragh; O'Kelly; Weissman; Kaplan; Journal of Pharmacokinetics and Biopharmaceutics; vol. 6; nb. 4; (1978); p. 283 - 293, View in Reaxys 566 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

Human Caucasian

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Population State

Healthy

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Repeated

Measurement Parameter

Vd/F

Unit

L/kg

Quantitative value

5.63

Boxenbaum; Posmanter; Macasieb; Geitner; Weinfeld; Moore; Darragh; O'Kelly; Weissman; Kaplan; Journal of Pharmacokinetics and Biopharmaceutics; vol. 6; nb. 4; (1978); p. 283 - 293, View in Reaxys 567 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

Human Caucasian

Population State

Healthy

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

ClH

Unit

L/h/kg

Quantitative value

0.235

Boxenbaum; Posmanter; Macasieb; Geitner; Weinfeld; Moore; Darragh; O'Kelly; Weissman; Kaplan; Journal of Pharmacokinetics and Biopharmaceutics; vol. 6; nb. 4; (1978); p. 283 - 293, View in Reaxys 568 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

Human Caucasian

Population State

Healthy

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

ER

Quantitative value

0.154

Boxenbaum; Posmanter; Macasieb; Geitner; Weinfeld; Moore; Darragh; O'Kelly; Weissman; Kaplan; Journal of Pharmacokinetics and Biopharmaceutics; vol. 6; nb. 4; (1978); p. 283 - 293, View in Reaxys 569 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

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Biological Species/NCBI ID

Human Caucasian

Population State

Healthy

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

Vd ss

Unit

L/kg

Quantitative value

3.76

Boxenbaum; Posmanter; Macasieb; Geitner; Weinfeld; Moore; Darragh; O'Kelly; Weissman; Kaplan; Journal of Pharmacokinetics and Biopharmaceutics; vol. 6; nb. 4; (1978); p. 283 - 293, View in Reaxys 570 of 976

571 of 976

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Wistar rat

Organs/Tissues

forebrain

Substance RN

702691View in Reaxys

Substance Name

Flunizatrepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.8

Measurement pX

8.55

Concomitants: Compound RN

754371; 754371

Concomitants: Compound name

Diazepam; [3H]-Diazepam

Concomitants: Compound role

NSB; RAD

Target Name

ionotropic gamma aminobutyric acid a receptor [human]

Target Synonyms

ionotropic gamma aminobutyric acid a receptor

Target, Subunit, Species

ionotropic gamma aminobutyric acid a receptor [human]

Target Mutant/Chimera Details

ionotropic gamma aminobutyric acid a receptor [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

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572 of 976

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

human

Population State

hypertension

Organs/Tissues

brain cortex

Cell Fraction

Homogenate/Centrifugation/Pellet

Substance RN

702691View in Reaxys

Substance Name

[3H]Flunitrazepam

Substance Dose

0.350000 nM

Measurement Parameter

kon

Unit

nM-1.min-1

Quantitative value

0.25

Deviation

0.0500000

Concomitants: Compound RN

759557

Concomitants: Compound name

Clonazepam

Concomitants: Compound role

NSB

Target Name

ionotropic gamma aminobutyric acid a receptor [human]

Target Synonyms

ionotropic gamma aminobutyric acid a receptor

Target, Subunit, Species

ionotropic gamma aminobutyric acid a receptor [human]

Target Mutant/Chimera Details

ionotropic gamma aminobutyric acid a receptor [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

human

Population State

hypertension

Organs/Tissues

brain cortex

Cell Fraction

Homogenate/Centrifugation/Pellet

Substance RN

702691View in Reaxys

Substance Name

[3H]Flunitrazepam

Substance Dose

0.350000 nM

Measurement Parameter

koff

Unit

min-1

Quantitative value

0.045

Deviation

0.00200000

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573 of 976

574 of 976

Concomitants: Compound RN

759557

Concomitants: Compound name

Clonazepam

Concomitants: Compound role

NSB

Target Name

ionotropic gamma aminobutyric acid a receptor [human]

Target Synonyms

ionotropic gamma aminobutyric acid a receptor

Target, Subunit, Species

ionotropic gamma aminobutyric acid a receptor [human]

Target Mutant/Chimera Details

ionotropic gamma aminobutyric acid a receptor [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

human

Population State

hypertension

Organs/Tissues

brain cortex

Cell Fraction

Homogenate/Centrifugation/Pellet

Substance RN

702691View in Reaxys

Substance Name

[3H]Flunitrazepam

Substance Dose

0.350000 nM

Measurement Parameter

Kd

Unit

nM

Quantitative value

0.18

Measurement pX

9.74

Concomitants: Compound RN

759557

Concomitants: Compound name

Clonazepam

Concomitants: Compound role

NSB

Target Name

ionotropic gamma aminobutyric acid a receptor [human]

Target Synonyms

ionotropic gamma aminobutyric acid a receptor

Target, Subunit, Species

ionotropic gamma aminobutyric acid a receptor [human]

Target Mutant/Chimera Details

ionotropic gamma aminobutyric acid a receptor [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

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Biological Species/NCBI ID

575 of 976

576 of 976

human

Population State

hypertension

Organs/Tissues

brain cortex

Cell Fraction

Homogenate/Centrifugation/Pellet

Substance RN

702691View in Reaxys

Substance Name

[3H]Flunitrazepam

Substance Dose

0.350000 nM

Measurement Parameter

t1/2 off

Unit

minute

Quantitative value

4.6

Concomitants: Compound RN

759557

Concomitants: Compound name

Clonazepam

Concomitants: Compound role

NSB

Target Name

ionotropic gamma aminobutyric acid a receptor [human]

Target Synonyms

ionotropic gamma aminobutyric acid a receptor

Target, Subunit, Species

ionotropic gamma aminobutyric acid a receptor [human]

Target Mutant/Chimera Details

ionotropic gamma aminobutyric acid a receptor [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

human

Population State

hypertension

Organs/Tissues

brain cortex

Cell Fraction

Homogenate/Centrifugation/Pellet

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

1.66

Deviation

0.0100000

Measurement pX

8.78

Concomitants: Compound RN

702691; 759557

Concomitants: Compound name

[3H]-Flunitrazepam; Clonazepam

Concomitants: Compound role

RAD; NSB

Target Name

ionotropic gamma aminobutyric acid a receptor [human]

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Target Synonyms

ionotropic gamma aminobutyric acid a receptor

Target, Subunit, Species

ionotropic gamma aminobutyric acid a receptor [human]

Target Mutant/Chimera Details

ionotropic gamma aminobutyric acid a receptor [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

human

Population State

hypertension

Organs/Tissues

brain cortex

Cell Fraction

Homogenate/Centrifugation/Pellet

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

6.2

Deviation

0.200000

Measurement pX

8.21

Concomitants: Compound RN

702691; 759557

Concomitants: Compound name

[3H]-Flunitrazepam; Clonazepam

Concomitants: Compound role

RAD; NSB

Target Name

ionotropic gamma aminobutyric acid a receptor [human]

Target Synonyms

ionotropic gamma aminobutyric acid a receptor

Target, Subunit, Species

ionotropic gamma aminobutyric acid a receptor [human]

Target Mutant/Chimera Details

ionotropic gamma aminobutyric acid a receptor [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

human

Population State

hypertension

Organs/Tissues

brain cortex

Cell Fraction

Homogenate/Centrifugation/Pellet

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

nH

Quantitative value

0.89

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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578 of 976

579 of 976

Deviation

0.0300000

Concomitants: Compound RN

702691; 759557

Concomitants: Compound name

[3H]-Flunitrazepam; Clonazepam

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-5; gabra-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2

Target Uniprot ID

p63079 + p19969 + p18508

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]flunitrazepam

Substance Dose

0 nM

Measurement Parameter

Kd

Unit

nM

Quantitative value

1.3

Deviation

0.180000

Measurement pX

8.89

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Substance Action on Target

Radioligand (/ligand)

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580 of 976

581 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Sprague Dawley rat

Organs/Tissues

hippocampus

Cells/Cell Lines

nerve cell

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]flunitrazepam

Substance Dose

0 nM

Measurement Parameter

Kd

Unit

nM

Quantitative value

1.5

Deviation

0.120000

Measurement pX

8.82

Target Name

Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-5; gabra-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5 + gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2

Target Uniprot ID

p63079 + p19969 + p18508

Target PDB ID

2pr9

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit gamma-2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]flunitrazepam

Substance Dose

0 nM

Measurement Parameter

Bmax

Unit

fmol/mg protein

Quantitative value

190

Deviation

12

Target Name

GABA-A receptor [Rattus norvegicus]

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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582 of 976

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Sprague Dawley rat

Organs/Tissues

hippocampus

Cells/Cell Lines

nerve cell

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]flunitrazepam

Substance Dose

0 nM

Measurement Parameter

Bmax

Unit

fmol/mg protein

Quantitative value

1712

Deviation

156

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Sprague Dawley rat

Organs/Tissues

brain cortex

Cells/Cell Lines

nerve cell

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]flunitrazepam

Substance Dose

0 nM

Measurement Parameter

Kd

Unit

nM

Quantitative value

1.5

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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583 of 976

584 of 976

Measurement pX

8.82

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Sprague Dawley rat

Organs/Tissues

brain cortex

Cells/Cell Lines

nerve cell

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

[3H]flunitrazepam

Substance Dose

0 nM

Measurement Parameter

Bmax

Unit

fmol/mg protein

Quantitative value

1160

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Wistar rat

Organs/Tissues

parotid gland

Cells/Cell Lines

cells

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

1.00000E-10 M

Measurement Parameter

Ki

Unit

nM

Quantitative value

3136

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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585 of 976

586 of 976

Deviation

700

Measurement pX

5.5

Concomitants: Compound RN

4763661; 4763661

Concomitants: Compound name

Flumazenil; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

GABA-A receptor [Rattus norvegicus]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Rattus norvegicus]

Target Mutant/Chimera Details

GABA-A receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Wistar rat

Organs/Tissues

submandibular gland

Cells/Cell Lines

cells

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

1.00000E-10 M

Measurement Parameter

Ki

Unit

nM

Quantitative value

3450

Deviation

480

Measurement pX

5.46

Concomitants: Compound RN

4763661; 4763661

Concomitants: Compound name

Flumazenil; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Wistar rat

Organs/Tissues

parotid gland

Cells/Cell Lines

cells

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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587 of 976

588 of 976

Substance Dose

1.00000E-10 M

Measurement Parameter

Ki

Unit

nM

Quantitative value

14.9

Deviation

2.60000

Measurement pX

7.83

Concomitants: Compound RN

4264456; 4264456

Concomitants: Compound name

PK 11195; [3H]-PK 11195

Concomitants: Compound role

NSB; RAD

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Wistar rat

Organs/Tissues

submandibular gland

Cells/Cell Lines

cells

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

1.00000E-10 M

Measurement Parameter

Ki

Unit

nM

Quantitative value

40.4

Deviation

4.10000

Measurement pX

7.39

Concomitants: Compound RN

4264456; 4264456

Concomitants: Compound name

PK 11195; [3H]-PK 11195

Concomitants: Compound role

NSB; RAD

Target Name

GABA-A receptor (Gamma 2L) [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p08220 + p08219

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [taurine cattle]; Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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589 of 976

Bioassay Name

Binding

Cells/Cell Lines

LTK-

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

8.9

Deviation

2.54000

Measurement pX

8.05

Concomitants: Compound RN

4763661

Concomitants: Compound name

[3H]-Ro 15-1788

Concomitants: Compound role

RAD

Target Name

GABA-A receptor (Gamma 2L) [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p08220 + p08219

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [taurine cattle]; Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Target Transfection

Transfected

Substance Action on Target

Agonist

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Cells/Cell Lines

LTK-

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

100 nM

Measurement Parameter

%

Unit

%

Measurement Object

of potentiation

Quantitative value

184

Deviation

43

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

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590 of 976

Concomitants: Compound role

COM

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Effect : |pharmacokinetics Bioassay : clearance ranged (CL), volume of distribution at steady-state (Vdss) and free fraction in plasma (fu) were calculated title comp. was infused into right jugular vein of rats (173-200 g) for 1 min; blood samples (100 μl) were collecteed from a small incision in the tail; title comp. conc. in blood were determined by HPLC-UV

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

10 mg/kg

Substance Route of Adm.

intravenous administration

Qualitative Results

CL 75.1 +/- 4.6 ml/min*kg; Vdss 5.3 +/- 0.6 l/kg; fu 11.1 +/- 0.2 percent (table)

Measurement Parameter

Qualitative

Hoogerkamp; Arends; Bomers; Mandema; Voskuyl; Danhof; Journal of Pharmacology and Experimental Therapeutics; vol. 279; nb. 2; (1996); p. 803 - 812, View in Reaxys 591 of 976

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Effect : |receptor; binding activity Bioassay : specific binding was assessed by subtracting the nonspecific binding (obtained in the presence of 10 mg/l flumazenil) from the total binding; binding characteristic was determined by applying an in vitro filtration assay receptor binding was determined in triplicate by displacement of <3H>-flumazenil at 37 deg C in a GABA-enriched invironment using various conc. of title comp.

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

10 mg/kg

Substance Route of Adm.

intravenous administration

Measurement Parameter

Ki

Unit

nM

Quantitative value

29

Measurement pX

7.54

Hoogerkamp; Arends; Bomers; Mandema; Voskuyl; Danhof; Journal of Pharmacology and Experimental Therapeutics; vol. 279; nb. 2; (1996); p. 803 - 812, View in Reaxys 592 of 976

Substance Effect

Anticonvulsant

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Bioassay : TLS: threshold for localized seizure activity; EC250 value was defined as the concentration needed to increase the TLS by 250 μA for the total plasma conc. (EC250) and the free conc. (EC250,u) direct cortical stimulation model; title comp. was infused into right jugular vein for 1 min; anticonvulsant effect was expressed as elevation over the averadge base-line TLS and determined during the 30-min period preceding title comp. administration

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

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Substance Dose

10 mg/kg

Substance Route of Adm.

intravenous administration

Qualitative Results

title comp. rapidly increased TLS by 300 to 500 μA immediately after administration; the effect slowly declined back to base-line in parallel with the decrease in blood concentration; EC250 = 1.2 +/- 0.3 mg/l; EC250,u = 0.21

Measurement Parameter

Qualitative

Hoogerkamp; Arends; Bomers; Mandema; Voskuyl; Danhof; Journal of Pharmacology and Experimental Therapeutics; vol. 279; nb. 2; (1996); p. 803 - 812, View in Reaxys 593 of 976

Bioassay Category

Metabolism/Transport

Bioassay Name

Binding

Biological Species/NCBI ID

human

Organs/Tissues

blood

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Blood/Plasma ratio

Quantitative value

0.78

Brown, Hayley S.; Griffin, Michael; Houston, J. Brian; Drug Metabolism and Disposition; vol. 35; nb. 2; (2007); p. 293 301, View in Reaxys 594 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

effect on human plasma protein binding of digoxin at 1 and 3 μg ml-1 (in-vitro)

Measurement Parameter

Qualitative

Castillo Ferrando; Carrasco Prieto; De La Torre Brasas; Journal of Pharmacy and Pharmacology; vol. 35; nb. 7; (1983); p. 462 - 463, View in Reaxys 595 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : Ltk- cells expressing human GABAA α6α3α2 receptorBioassay : affinity measured by competition for <3H>Ro15-1788, incubation at 4 deg C in phosphate buffer (pH=7.4), radioactivity detected by liquid scintillation counting

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1.00000E-09 M

Qualitative Results

not active up to a concentration of 1 μM

Measurement Parameter

Qualitative

Huang, Qi; Zhang, Weijiang; Liu, Ruiyan; McKernan, Ruth M.; Cook, James M.; Medicinal Chemistry Research; vol. 6; nb. 6; (1996); p. 384 - 391, View in Reaxys 596 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : Ltk- cells expressing human GABAA α1α3α2 receptorBioassay : affinity measured by competition for <3H>Ro15-1788, incubation at 4 deg C in phosphate buffer (pH=7.4), radioactivity detected by liquid scintillation counting

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1.00000E-09 M

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Measurement Parameter

Ki

Unit

nM

Quantitative value

2.2

Measurement pX

8.66

Huang, Qi; Zhang, Weijiang; Liu, Ruiyan; McKernan, Ruth M.; Cook, James M.; Medicinal Chemistry Research; vol. 6; nb. 6; (1996); p. 384 - 391, View in Reaxys 597 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : Ltk- cells expressing human GABAA α2α3α2 receptorBioassay : affinity measured by competition for <3H>Ro15-1788, incubation at 4 deg C in phosphate buffer (pH=7.4), radioactivity detected by liquid scintillation counting

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1.00000E-09 M

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.5

Measurement pX

8.6

Huang, Qi; Zhang, Weijiang; Liu, Ruiyan; McKernan, Ruth M.; Cook, James M.; Medicinal Chemistry Research; vol. 6; nb. 6; (1996); p. 384 - 391, View in Reaxys 598 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : Ltk- cells expressing human GABAA α3α3α2 receptorBioassay : affinity measured by competition for <3H>Ro15-1788, incubation at 4 deg C in phosphate buffer (pH=7.4), radioactivity detected by liquid scintillation counting

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1.00000E-09 M

Measurement Parameter

Ki

Unit

nM

Quantitative value

4.5

Measurement pX

8.35

Huang, Qi; Zhang, Weijiang; Liu, Ruiyan; McKernan, Ruth M.; Cook, James M.; Medicinal Chemistry Research; vol. 6; nb. 6; (1996); p. 384 - 391, View in Reaxys 599 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : Ltk- cells expressing human GABAA α5α3α2 receptorBioassay : affinity measured by competition for <3H>Ro15-1788, incubation at 4 deg C in phosphate buffer (pH=7.4), radioactivity detected by liquid scintillation counting

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1.00000E-09 M

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.1

Measurement pX

8.68

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

332/493

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Huang, Qi; Zhang, Weijiang; Liu, Ruiyan; McKernan, Ruth M.; Cook, James M.; Medicinal Chemistry Research; vol. 6; nb. 6; (1996); p. 384 - 391, View in Reaxys 600 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

parameters of binding to serum proteins at pH 7.4, obtained from the fluorescence method

Measurement Parameter

Qualitative

Maruyama; Furuie; Hibino; Otagiri; Journal of Pharmaceutical Sciences; vol. 81; nb. 1; (1992); p. 16 - 20, View in Reaxys 601 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : human α5α3α2 GABAA receptor expr. in mouse L(tk-) cellsBioassay : membranes prep. from cell monolayers incubated with 0.5 nM <3H>Ro15-1788 in pres. of title comp. at 4 degC, 90 min; filtrated; displacement of radioligand detd. from filter-retained radioactivity by liquid scintillation counting

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.11

Measurement pX

8.68

Hadingham; Wafford; Thompson; Palmer; Whiting; European Journal of Pharmacology - Molecular Pharmacology Section; vol. 291; nb. 3; (1995); p. 301 - 309, View in Reaxys 602 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : human α5α3α3 GABAA receptor expr. in mouse L(tk-) cellsBioassay : membranes prep. from cell monolayers incubated with 0.5 nM <3H>Ro15-1788 in pres. of title comp. at 4 degC, 90 min; filtrated; displacement of radioligand detd. from filter-retained radioactivity by liquid scintillation counting

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

Ki

Unit

nM

Quantitative value

11

Measurement pX

7.96

Hadingham; Wafford; Thompson; Palmer; Whiting; European Journal of Pharmacology - Molecular Pharmacology Section; vol. 291; nb. 3; (1995); p. 301 - 309, View in Reaxys 603 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : human α1α2α2 GABAA receptor expr. in Xenopus oocytesBioassay : EC50 = conc. of title comp. eliciting half maximal response cells impaled with two 1-3 MOhm electrodes cont. 2M KCl, voltage clamped between -40 - -70 mV; perfused with saline; title comp. added to perfusate 30 sec prior to addition of GABA; current response recorded ca. 30 sec

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

EC50

Unit

nM

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Quantitative value

6.9

Measurement pX

8.16

Hadingham; Wafford; Thompson; Palmer; Whiting; European Journal of Pharmacology - Molecular Pharmacology Section; vol. 291; nb. 3; (1995); p. 301 - 309, View in Reaxys 604 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : human α1α2α3 GABAA receptor expr. in Xenopus oocytesBioassay : EC50 = conc. of title comp. eliciting half maximal response cells impaled with two 1-3 MOhm electrodes cont. 2M KCl, voltage clamped between -40 - -70 mV; perfused with saline; title comp. added to perfusate 30 sec prior to addition of GABA; current response recorded ca. 30 sec

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

EC50

Unit

nM

Quantitative value

110.7

Measurement pX

6.95

Hadingham; Wafford; Thompson; Palmer; Whiting; European Journal of Pharmacology - Molecular Pharmacology Section; vol. 291; nb. 3; (1995); p. 301 - 309, View in Reaxys 605 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Bioassay : binding parameters (KD, nM; Bmax, fmol/mg protein) determined by Scatchard analysis membranes from cerebellum of adult rats incub. in buffer (pH 7.4; 90 min; 4 deg C) with <3H>labeled title comp. +/- 10 μM diazepam; binding determined with liquid scintillation

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

2 nM

Qualitative Results

KD: 2.8; Bmax: 1332

Measurement Parameter

Qualitative

Slany; Zezula; Fuchs; Sieghart; European Journal of Pharmacology - Molecular Pharmacology Section; vol. 291; nb. 2; (1995); p. 99 - 105, View in Reaxys 606 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Bioassay : binding parameters (KD, nM; Bmax, fmol/mg protein) determined by Scatchard analysis HEK cells, native or transfected with cDNAs for rat GABAA receptor α1α3α2- or α1α2-subunits incub. in buffer (pH 7.4; 90 min; 4 deg C) with <3H>labeled title comp. +/- 10 μM diazepam; binding determined with liquid scintillation

Biological Species/NCBI ID

human

Cells/Cell Lines

HEK293 cell line

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

2 nM

Qualitative Results

increased binding in transfected cells (fmol/mg protein, native: 20; α1α2: 46, KD: 10.9; Bmax: 240; α1α3α2: 246, KD: 3.53; Bmax: 705)

Measurement Parameter

Qualitative

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Slany; Zezula; Fuchs; Sieghart; European Journal of Pharmacology - Molecular Pharmacology Section; vol. 291; nb. 2; (1995); p. 99 - 105, View in Reaxys 607 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : PA3 cellsBioassay : effect on (GABA)A receptor function; Kd, Bmax, GABA shift cells cultured in Dulbecco's modified Eagle's medium; induction with 1 μM dexamethasone; after 2 d 10 μM title comp. and 50 μM GABA

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

Kd = 5.72 nM, Bmax = 141 percent of control, GABA shift: 1.35

Measurement Parameter

Qualitative

Klein; Mascia; Harkness; Hadingham; Whiting; Harris; Journal of Pharmacology and Experimental Therapeutics; vol. 274; nb. 3; (1995); p. 1484 - 1492, View in Reaxys 608 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : PA3 cellsBioassay : effect on (GABA)A receptor subunit α1, α1 protein cells cultured in Dulbecco's modified Eagle's medium; induction with 1 μM dexamethasone; after 2 d 100 μM title comp. and 50 μM GABA; Western blot analysis

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

Qualitative

Qualitative value

NA

Measurement pX

1

Klein; Mascia; Harkness; Hadingham; Whiting; Harris; Journal of Pharmacology and Experimental Therapeutics; vol. 274; nb. 3; (1995); p. 1484 - 1492, View in Reaxys 609 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : PA3 cellsBioassay : effect on (GABA)A receptor subunit mRNAs: α1, α1, α2L cells cultured in Dulbecco's modified Eagle's medium; induction with 1 μM dexamethasone; after 2 d 100 μM title comp. and 50 μM GABA; Northern blot analysis

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

Qualitative

Qualitative value

NA

Measurement pX

1

Klein; Mascia; Harkness; Hadingham; Whiting; Harris; Journal of Pharmacology and Experimental Therapeutics; vol. 274; nb. 3; (1995); p. 1484 - 1492, View in Reaxys 610 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Bioassay : elution front and plateau obtained binding on multiple-receptor stationary phase (MR-SP) studied; MR-SP prepared from homogenized brains and IAM-PC packing material; filled into chromatographic coloumn; mobile phase: Tris*HCl pH 7.4 containing title comp.

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.0500000 nM

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Qualitative Results

dissociation constant on GABAA receptor determined by frontal chromatography: 1.3 nmol/l

Measurement Parameter

Qualitative

Moaddel; Cloix; Ertem; Wainer; Pharmaceutical Research; vol. 19; nb. 1; (2002); p. 104 - 107, View in Reaxys 611 of 976

612 of 976

613 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

human

Organs/Tissues

brain cortex

Cell Fraction

Cytoplasmic membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.72

Measurement pX

8.57

Concomitants: Compound RN

702691; 702691

Concomitants: Compound name

Flunitrazepam; [3H]-Flunitrazepam

Concomitants: Compound role

NSB; RAD

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

human

Organs/Tissues

brain cortex

Cell Fraction

Cytoplasmic membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

nH

Quantitative value

1.095

Deviation

0.131000

Concomitants: Compound RN

702691; 702691

Concomitants: Compound name

Flunitrazepam; [3H]-Flunitrazepam

Concomitants: Compound role

NSB; RAD

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

human

Organs/Tissues

frontal cortex

Cell Fraction

Homogenate

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

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614 of 976

615 of 976

616 of 976

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.2

Deviation

0.500000

Measurement pX

8.66

Concomitants: Compound RN

754371; 754371

Concomitants: Compound name

Diazepam; [3H]-Diazepam

Concomitants: Compound role

NSB; RAD

Substance Effect

Anticonvulsant

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

ED50

Unit

µmol/kg

Quantitative value

0.32

Concomitants: Compound RN

135492

Concomitants: Compound name

Pentetrazole

Concomitants: Compound role

IAV

Substance Effect

Anxiolytic

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

ED50

Unit

µmol/kg

Quantitative value

2.5

Target Name

Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit alpha-5; gabra-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5

Target Uniprot ID

p19969

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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617 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

hippocampus

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

6.51

Deviation

1.23000

Measurement pX

8.19

Concomitants: Compound RN

8080906; 702691

Concomitants: Compound name

[3H]-L-655,708; Flunitrazepam

Concomitants: Compound role

RAD; NSB

Target Name

Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit alpha-5; gabra-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5

Target Uniprot ID

p19969

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

hippocampus

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

nH

Quantitative value

0.94

Deviation

0.120000

Concomitants: Compound RN

8080906; 702691

Concomitants: Compound name

[3H]-L-655,708; Flunitrazepam

Concomitants: Compound role

RAD; NSB

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618 of 976

619 of 976

Target Name

Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus];+GABA-A receptor (Gamma 2S) [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-3 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-3; gabra-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p63138 + p20236

Target PDB ID

4tk1; 4tk2; 4tk3; 4tk4; 4u90

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit alpha-3 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild + GABA-A receptor (Gamma 2S) [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Substance Action on Target

Agonist

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Cells/Cell Lines

HEK293 cell line

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.00100000 µM

Measurement Parameter

EC50

Unit

nM

Quantitative value

31

Deviation

16

Measurement pX

7.51

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus];+GABA-A receptor (Gamma 2S) [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit alpha-5; gabra-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba-a receptor (gamma 2s)

Target Uniprot ID

p19969 + p63138

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild + GABA-A receptor (Gamma 2S) [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

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620 of 976

Substance Action on Target

Agonist

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Cells/Cell Lines

HEK293 cell line

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

0.00100000 µM

Measurement Parameter

EC50

Unit

nM

Quantitative value

2

Deviation

1

Measurement pX

8.7

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus];+GABA-A receptor (Gamma 2S) [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-3 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-3; gabra-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p63138 + p20236

Target PDB ID

4tk1; 4tk2; 4tk3; 4tk4; 4u90

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit alpha-3 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild + GABA-A receptor (Gamma 2S) [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Substance Action on Target

Agonist

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Cells/Cell Lines

HEK293 cell line

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

% Stimulation

Unit

%

Quantitative value

128

Deviation

22

Measurement pX

7.28

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621 of 976

622 of 976

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus];+GABA-A receptor (Gamma 2S) [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit alpha-5; gabra-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5 + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba-a receptor (gamma 2s)

Target Uniprot ID

p19969 + p63138

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-5 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild + GABA-A receptor (Gamma 2S) [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Transfected

Substance Action on Target

Agonist

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Cells/Cell Lines

HEK293 cell line

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

100 nM

Measurement Parameter

% Stimulation

Unit

%

Quantitative value

155

Deviation

32

Measurement pX

8.28

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

free fraction (percent unbound = 22.5) of normal human plasma is concentration independent at conc. of the drug ranging from 10 to 10000 ng ml-1 (dialysis for 20 h at 37 deg C and pH 7.4)

Measurement Parameter

Qualitative

Moschitto; Greenblatt; Journal of Pharmacy and Pharmacology; vol. 35; nb. 3; (1983); p. 179 - 180, View in Reaxys 623 of 976

Bioassay Category

In Vitro (Efficacy)

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Bioassay Name

Binding

Bioassay Details

Effect : |receptor; binding activity Target : human GABAA receptors expressed in mouse L(tk-) fibroblastBioassay : Ki=IC50/(1+<radioligand>/Kd), Kd=mean value for radioligand/receptor α1α3α2S receptors stably expressed in fibroblast cells; binding affinities (as Ki) determined in competition assay with 0.75 nM <3H>Ro 15-1788; liquid scintillation

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

Ki

Unit

nM

Quantitative value

5.2

Measurement pX

8.28

Hadingham, Karen L.; Garrett, Elizabeth M.; Wafford, Keith A.; Bain, Corinna; Heavens, Robert P.; Sirinathsinghji, Dalip J. S.; Whiting, Paul J.; Molecular Pharmacology; vol. 49; nb. 2; (1996); p. 253 - 259, View in Reaxys 624 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Bioassay Details

Effect : |receptor; binding activity Target : human GABAA receptors expressed in mouse L(tk-) fibroblastBioassay : Ki=IC50/(1+<radioligand>/Kd), Kd=mean value for radioligand/receptor α6α3α2S receptors stably expressed in fibroblast cells; binding affinities (as Ki) determined in competition assay with 5 nM <3H>Ro 15-4513; liquid scintillation

Substance RN

702691View in Reaxys

Substance Name

31870

Measurement Parameter

Ki

Unit

nM

Quantitative value

1000

Measurement pX

6

Hadingham, Karen L.; Garrett, Elizabeth M.; Wafford, Keith A.; Bain, Corinna; Heavens, Robert P.; Sirinathsinghji, Dalip J. S.; Whiting, Paul J.; Molecular Pharmacology; vol. 49; nb. 2; (1996); p. 253 - 259, View in Reaxys 625 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : drug interactionTarget : human GABAA receptors expressed in Xenopus oocytesBioassay : oocytes placed in bath with modified Barth's medium and impaled with two 1-3 Mα containing 2M KCl; voltage-clamp; title comp. preapplied 30 s before GABA; concetration-response curves α6α2α2S and α1α2α2S receptors (α6 and α1); effect of title comp. on α-aminobutyric acid (GABA) currents in oocytes

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1 µM

Qualitative Results

title comp. potentiated effect of GABA in α1; no effect in α6

Measurement Parameter

Qualitative

Hadingham, Karen L.; Garrett, Elizabeth M.; Wafford, Keith A.; Bain, Corinna; Heavens, Robert P.; Sirinathsinghji, Dalip J. S.; Whiting, Paul J.; Molecular Pharmacology; vol. 49; nb. 2; (1996); p. 253 - 259, View in Reaxys 626 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : human GABAA receptors in human embryonic kidney 293 cellsBioassay : cells transiently transfected with α6α1α2S receptors; affinities of title comp. determined by inhibition of <3H>Ro 15-4513 binding in membranes

Substance RN

702691View in Reaxys

Substance Name

31870

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Substance Dose

1.00000E-07 M

Qualitative Results

had a biphasic curve with low (IC50=380 nM) and high affinity (IC50=14 nM)

Measurement Parameter

Qualitative

Hadingham, Karen L.; Garrett, Elizabeth M.; Wafford, Keith A.; Bain, Corinna; Heavens, Robert P.; Sirinathsinghji, Dalip J. S.; Whiting, Paul J.; Molecular Pharmacology; vol. 49; nb. 2; (1996); p. 253 - 259, View in Reaxys 627 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : human GABAA receptors in human embryonic kidney 293 cellsBioassay : cells transiently transfected with α1α1α2S receptors; affinities of title comp. determined by inhibition of <3H>Ro 15-4513 binding in membranes

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1.00000E-10 M

Measurement Parameter

IC50

Unit

nM

Quantitative value

14

Measurement pX

7.85

Hadingham, Karen L.; Garrett, Elizabeth M.; Wafford, Keith A.; Bain, Corinna; Heavens, Robert P.; Sirinathsinghji, Dalip J. S.; Whiting, Paul J.; Molecular Pharmacology; vol. 49; nb. 2; (1996); p. 253 - 259, View in Reaxys 628 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : human GABAA receptors in human embryonic kidney 293 cellsBioassay : cells transiently transfected with α6α1α2S receptors; affinities of title comp. determined by inhibition of <3H>Ro 15-4513 binding in membranes

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1.00000E-10 M

Measurement Parameter

IC50

Unit

nM

Quantitative value

210

Measurement pX

6.68

Hadingham, Karen L.; Garrett, Elizabeth M.; Wafford, Keith A.; Bain, Corinna; Heavens, Robert P.; Sirinathsinghji, Dalip J. S.; Whiting, Paul J.; Molecular Pharmacology; vol. 49; nb. 2; (1996); p. 253 - 259, View in Reaxys 629 of 976

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human];+GABA-A receptor (Gamma 2S) [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1 + gaba-a receptor (gamma 2s)

Target Uniprot ID

p18505 + p14867

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

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630 of 976

631 of 976

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

11.5

Deviation

1.60000

Measurement pX

7.94

Concomitants: Compound RN

702691; 4763661

Concomitants: Compound name

Flunitrazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+Gamma-aminobutyric acid receptor subunit alpha-2 [human];+GABA-A receptor (Gamma 2S) [human]

Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba(a) receptor subunit alpha-2; gabra2; gamma-aminobutyric acid receptor subunit alpha-2 + gaba-a receptor (gamma 2s)

Target Uniprot ID

p18505 + p47869

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-2 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-2 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

5.2

Deviation

0.400000

Measurement pX

8.28

Concomitants: Compound RN

702691; 4763661

Concomitants: Compound name

Flunitrazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human];+Gamma-aminobutyric acid receptor subunit alpha-3 [human]

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Target Synonyms

gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s) + gaba(a) receptor subunit alpha-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p18505 + p34903

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-3 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

15.7

Deviation

3.60000

Measurement pX

7.8

Concomitants: Compound RN

702691; 4763661

Concomitants: Compound name

Flunitrazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

Gamma-aminobutyric acid receptor subunit alpha-5 [human];+Gamma-aminobutyric acid receptor subunit beta-1 [human];+GABA-A receptor (Gamma 2S) [human]

Target Synonyms

gaba(a) receptor subunit alpha-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5 + gaba(a) receptor subunit beta-1; gabrb1; gamma-aminobutyric acid receptor subunit beta-1 + gaba-a receptor (gamma 2s)

Target Uniprot ID

p31644 + p18505

Target, Subunit, Species

GABA-A receptor (Gamma 2S) [human]; Gamma-aminobutyric acid receptor subunit alpha-5 [human]; Gamma-aminobutyric acid receptor subunit beta-1 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit alpha-5 [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-1 [human]:Wild + GABA-A receptor (Gamma 2S) [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Cells/Cell Lines

HEK293 cell line

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

Ki

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Unit

nM

Quantitative value

5.5

Deviation

0.400000

Measurement pX

8.26

Concomitants: Compound RN

702691; 4763661

Concomitants: Compound name

Flunitrazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : neural network activity; reduction ofTarget : hippocampal neuron culture of Sprague-Dawley ratBioassay : 00235] Example 6 : Mg++ and GABAB Agonists Increase Synaptic Plasticiy on a Long Term Basis ; Various Other Agents that Reduce Ca++ Flux Increase Synaptic Plasticity on a Short Term Basis. [00236] We sought to assess the ability of various treatments to increase synaptic plasticity. In functional neural

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

pre-treatment with title compound at 5 µmol/l for 48 hours inhibited global neuronal network activity; but no effect on synaptic plasticity was observed (figures are given)

Measurement Parameter

Qualitative

Patent; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; WO2005/37215; (2005); (A2) English, View in Reaxys 634 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : plasticity of presynaptic terminals; enhancing ofTarget : hippocampal neuron culture of Sprague-Dawley ratBioassay : 00235] Example 6 : Mg++ and GABAB Agonists Increase Synaptic Plasticiy on a Long Term Basis ; Various Other Agents that Reduce Ca++ Flux Increase Synaptic Plasticity on a Short Term Basis. [00236] We sought to assess the ability of various treatments to increase synaptic plasticity. In functional neural

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

pre-treatment with title compound at 5 µmol/l for 4-6 hours led to enhancing of inhibitory synaptic transmission and corresponding reduction in overall activity of neural network, resulting in formation of a highly plastic network (increase in

Measurement Parameter

Qualitative

Patent; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; WO2005/37215; (2005); (A2) English, View in Reaxys 635 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

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Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Vmax

Unit

pmol/min/pmol target

Quantitative value

0.2

Deviation

0.0100000

Metabolite RN

1226636; 568966; 576896; 1169840; 688458; 713494; 751823; 759300

Metabolite name

4-Hydroxyalprazolam; alpha-Hydroxyalprazolam; alpha-Hydroxytriazolam; 4-Hydroxytriazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Vmax

Unit

pmol/min/pmol target

Quantitative value

1.29

Deviation

0.0500000

Metabolite RN

1226636; 568966; 576896; 1169840; 688458; 713494; 751823; 759300

Metabolite name

4-Hydroxyalprazolam; alpha-Hydroxyalprazolam; alpha-Hydroxytriazolam; 4-Hydroxytriazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

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638 of 976

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

S50

Unit

mM

Quantitative value

694

Deviation

104

Metabolite RN

568966; 1169840; 688458; 713494; 751823; 759300

Metabolite name

alpha-Hydroxyalprazolam; 4-Hydroxytriazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

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Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

S50

Unit

mM

Quantitative value

224

Deviation

44

Metabolite RN

568966; 1169840; 688458; 713494; 751823; 759300

Metabolite name

alpha-Hydroxyalprazolam; 4-Hydroxytriazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Clmax

Unit

mL/min/nmol target

Quantitative value

0.9

Metabolite RN

568966; 1169840; 688458; 713494; 751823; 759300

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640 of 976

641 of 976

Metabolite name

alpha-Hydroxyalprazolam; 4-Hydroxytriazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Clmax

Unit

mL/min/nmol target

Quantitative value

5.7

Metabolite RN

568966; 1169840; 688458; 713494; 751823; 759300

Metabolite name

alpha-Hydroxyalprazolam; 4-Hydroxytriazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

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Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Alpha

Quantitative value

0.03

Deviation

0.0100000

Metabolite RN

568966; 1169840; 688458; 713494; 751823; 759300

Metabolite name

alpha-Hydroxyalprazolam; 4-Hydroxytriazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Alpha

Quantitative value

0.36

Deviation

0.190000

Metabolite RN

568966; 1169840; 688458; 713494; 751823; 759300

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643 of 976

644 of 976

Metabolite name

alpha-Hydroxyalprazolam; 4-Hydroxytriazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

Cytochrome P450 3A5 [human]

Target Synonyms

cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 hlp2; cytochrome p450-pcn3

Target Uniprot ID

p20815

Target, Subunit, Species

Cytochrome P450 3A5 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A5 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Vmax

Unit

pmol/min/pmol target

Quantitative value

0.14

Deviation

0.0100000

Metabolite RN

1226636; 568966; 576896; 1169840; 688458; 713494; 751823; 759300

Metabolite name

4-Hydroxyalprazolam; alpha-Hydroxyalprazolam; alpha-Hydroxytriazolam; 4-Hydroxytriazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

Cytochrome P450 3A5 [human]

Target Synonyms

cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 hlp2; cytochrome p450-pcn3

Target Uniprot ID

p20815

Target, Subunit, Species

Cytochrome P450 3A5 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A5 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

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645 of 976

646 of 976

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Vmax

Unit

pmol/min/pmol target

Quantitative value

2.38

Deviation

0.0500000

Metabolite RN

1226636; 568966; 576896; 1169840; 688458; 713494; 751823; 759300

Metabolite name

4-Hydroxyalprazolam; alpha-Hydroxyalprazolam; alpha-Hydroxytriazolam; 4-Hydroxytriazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

Cytochrome P450 3A5 [human]

Target Synonyms

cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 hlp2; cytochrome p450-pcn3

Target Uniprot ID

p20815

Target, Subunit, Species

Cytochrome P450 3A5 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A5 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

S50

Unit

mM

Quantitative value

337

Deviation

32

Metabolite RN

1226636; 568966; 1169840; 713494; 751823; 759300

Metabolite name

4-Hydroxyalprazolam; alpha-Hydroxyalprazolam; 4-Hydroxytriazolam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

Cytochrome P450 3A5 [human]

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647 of 976

Target Synonyms

cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 hlp2; cytochrome p450-pcn3

Target Uniprot ID

p20815

Target, Subunit, Species

Cytochrome P450 3A5 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A5 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Clmax

Unit

mL/min/nmol target

Quantitative value

13.4

Metabolite RN

1226636; 568966; 1169840; 713494; 751823; 759300

Metabolite name

4-Hydroxyalprazolam; alpha-Hydroxyalprazolam; 4-Hydroxytriazolam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

Cytochrome P450 3A5 [human]

Target Synonyms

cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 hlp2; cytochrome p450-pcn3

Target Uniprot ID

p20815

Target, Subunit, Species

Cytochrome P450 3A5 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A5 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Km

Unit

mM

Quantitative value

128

Deviation

21

Metabolite RN

576896; 688458

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649 of 976

Metabolite name

alpha-Hydroxytriazolam; Desmethylflunitrazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

Cytochrome P450 3A5 [human]

Target Synonyms

cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 hlp2; cytochrome p450-pcn3

Target Uniprot ID

p20815

Target, Subunit, Species

Cytochrome P450 3A5 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A5 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Clint

Unit

mL/min/nmol target

Quantitative value

1.09

Metabolite RN

576896; 688458

Metabolite name

alpha-Hydroxytriazolam; Desmethylflunitrazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

Cytochrome P450 3A5 [human]

Target Synonyms

cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 hlp2; cytochrome p450-pcn3

Target Uniprot ID

p20815

Target, Subunit, Species

Cytochrome P450 3A5 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A5 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

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650 of 976

651 of 976

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Alpha

Quantitative value

0.07

Deviation

0.0200000

Metabolite RN

568966; 1169840; 713494; 751823; 759300

Metabolite name

alpha-Hydroxyalprazolam; 4-Hydroxytriazolam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

Cytochrome P450 2C19 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase

Target Uniprot ID

p33261

Target PDB ID

4gqs

Target, Subunit, Species

Cytochrome P450 2C19 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Vmax

Unit

pmol/min/pmol target

Quantitative value

0.064

Deviation

0.00300000

Metabolite RN

688458; 713494; 751823; 759300

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

Cytochrome P450 2C19 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase

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652 of 976

Target Uniprot ID

p33261

Target PDB ID

4gqs

Target, Subunit, Species

Cytochrome P450 2C19 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Vmax

Unit

pmol/min/pmol target

Quantitative value

0.5

Deviation

0.0700000

Metabolite RN

688458; 713494; 751823; 759300

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

Cytochrome P450 2C19 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase

Target Uniprot ID

p33261

Target PDB ID

4gqs

Target, Subunit, Species

Cytochrome P450 2C19 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Clint

Unit

mL/min/nmol target

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653 of 976

654 of 976

Quantitative value

0.72

Metabolite RN

688458; 713494; 751823; 759300

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

Cytochrome P450 2C19 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase

Target Uniprot ID

p33261

Target PDB ID

4gqs

Target, Subunit, Species

Cytochrome P450 2C19 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Clint

Unit

mL/min/nmol target

Quantitative value

1.7

Metabolite RN

688458; 713494; 751823; 759300

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

Cytochrome P450 2C19 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase

Target Uniprot ID

p33261

Target PDB ID

4gqs

Target, Subunit, Species

Cytochrome P450 2C19 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild

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655 of 976

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Beta

Quantitative value

0.28

Deviation

0.100000

Metabolite RN

688458; 751823; 759300

Metabolite name

Desmethylflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

Cytochrome P450 2C19 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cyp2c19; cypiic17; cypiic19; cytochrome p450 2c19; cytochrome p450-11a; cytochrome p450-254c; mephenytoin 4-hydroxylase

Target Uniprot ID

p33261

Target PDB ID

4gqs

Target, Subunit, Species

Cytochrome P450 2C19 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C19 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Cells/Cell Lines

BTI-Tn-5B1-4 cell line

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Km

Unit

mM

Quantitative value

89

Deviation

13

Measurement pX

1.05

Metabolite RN

713494

Metabolite name

3-Hydroxyflunitrazepam

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657 of 976

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Target Name

GABA-A receptor (Gamma 2L) [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p0c2w5 + p08219

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [taurine cattle]; Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Target Transfection

Transfected

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Mus musculus

Cells/Cell Lines

fibroblast

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

EC50

Unit

nM

Quantitative value

23.1

Deviation

9.10000

Measurement pX

7.64

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

GABA-A receptor (Gamma 2L) [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]

Target Synonyms

gaba-a receptor (gamma 2l) + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p0c2w5 + p08219

Target, Subunit, Species

GABA-A receptor (Gamma 2L) [taurine cattle]; Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle]

Target Mutant/Chimera Details

GABA-A receptor (Gamma 2L) [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]:Wild

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658 of 976

Target Species (Bioactivity)

taurine cattle

Target Transfection

Transfected

Substance Action on Target

Allosteric Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Electrophysiology

Biological Species/NCBI ID

Mus musculus

Cells/Cell Lines

fibroblast

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Emax(%)

Unit

%

Measurement Object

maximum of GABA reponse

Quantitative value

208

Deviation

27

Concomitants: Compound RN

906818

Concomitants: Compound name

GABA

Concomitants: Compound role

AGO

Target Name

UDP-glucuronosyltransferase 1-3 [human]; UDP-glucuronosyltransferase 2B15 [human]; UDPglucuronosyltransferase 1-1 [human]

Target Synonyms

gnt1; udp-glucuronosyltransferase 1-3; udp-glucuronosyltransferase 1-c; udp-glucuronosyltransferase 1a3; udpgt 1-3; ugt-1c; ugt1; ugt1*3; ugt1-03; ugt1.3; ugt1a3; ugt1c + hlug4; udp-glucuronosyltransferase 2b15; udp-glucuronosyltransferase 2b8; udpgt 2b15; udpgt 2b8; udpgth-3; ugt2b15; ugt2b8 + bilirubin-specific udpgt isozyme 1; gnt1; hug-br1; udp-glucuronosyltransferase 1-1; udpglucuronosyltransferase 1-a; udp-glucuronosyltransferase 1a1; udpgt 1-1; ugt-1a; ugt1; ugt1*1; ugt1-01; ugt1.1; ugt1a; ugt1a1

Target Uniprot ID

p35503 + p54855 + p22309

Target, Subunit, Species

UDP-glucuronosyltransferase 1-3 [human]; UDP-glucuronosyltransferase 2B15 [human]; UDPglucuronosyltransferase 1-1 [human]

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 1-3 [human]:Wild; UDP-glucuronosyltransferase 2B15 [human]:Wild; UDP-glucuronosyltransferase 1-1 [human]:Wild

Target Species (Bioactivity)

human; human; human

Target Transfection

Non Transfected; Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

100 µM

Measurement Parameter

% Inhibition

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659 of 976

Unit

%

Quantitative value

62.6

Measurement pX

4.22

Metabolite RN

7962987

Metabolite name

SCH 60663

Concomitants: Compound RN

78881; 85594; 24143771; 1098229; 7981967

Concomitants: Compound name

Uridine 5'-diphosphoglucuronic acid; Saccharo-1,4-lactone; Alamethicin; Methanol; [14C]-Ezetimibe

Concomitants: Compound role

COM; COM; COM; SLV; SUB

Target Name

UDP-glucuronosyltransferase 1-3 [human]; UDP-glucuronosyltransferase 2B15 [human]; UDPglucuronosyltransferase 1-1 [human]

Target Synonyms

gnt1; udp-glucuronosyltransferase 1-3; udp-glucuronosyltransferase 1-c; udp-glucuronosyltransferase 1a3; udpgt 1-3; ugt-1c; ugt1; ugt1*3; ugt1-03; ugt1.3; ugt1a3; ugt1c + hlug4; udp-glucuronosyltransferase 2b15; udp-glucuronosyltransferase 2b8; udpgt 2b15; udpgt 2b8; udpgth-3; ugt2b15; ugt2b8 + bilirubin-specific udpgt isozyme 1; gnt1; hug-br1; udp-glucuronosyltransferase 1-1; udpglucuronosyltransferase 1-a; udp-glucuronosyltransferase 1a1; udpgt 1-1; ugt-1a; ugt1; ugt1*1; ugt1-01; ugt1.1; ugt1a; ugt1a1

Target Uniprot ID

p35503 + p54855 + p22309

Target, Subunit, Species

UDP-glucuronosyltransferase 1-3 [human]; UDP-glucuronosyltransferase 2B15 [human]; UDPglucuronosyltransferase 1-1 [human]

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 1-3 [human]:Wild; UDP-glucuronosyltransferase 2B15 [human]:Wild; UDP-glucuronosyltransferase 1-1 [human]:Wild

Target Species (Bioactivity)

human; human; human

Target Transfection

Non Transfected; Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

200 µM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

86.1

Measurement pX

4.49

Metabolite RN

7962987

Metabolite name

SCH 60663

Concomitants: Compound RN

78881; 85594; 24143771; 1098229; 7981967

Concomitants: Compound name

Uridine 5'-diphosphoglucuronic acid; Saccharo-1,4-lactone; Alamethicin; Methanol; [14C]-Ezetimibe

Concomitants: Compound role

COM; COM; COM; SLV; SUB

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660 of 976

661 of 976

Target Name

UDP-glucuronosyltransferase 1-3 [human]; UDP-glucuronosyltransferase 2B15 [human]; UDPglucuronosyltransferase 1-1 [human]

Target Synonyms

gnt1; udp-glucuronosyltransferase 1-3; udp-glucuronosyltransferase 1-c; udp-glucuronosyltransferase 1a3; udpgt 1-3; ugt-1c; ugt1; ugt1*3; ugt1-03; ugt1.3; ugt1a3; ugt1c + hlug4; udp-glucuronosyltransferase 2b15; udp-glucuronosyltransferase 2b8; udpgt 2b15; udpgt 2b8; udpgth-3; ugt2b15; ugt2b8 + bilirubin-specific udpgt isozyme 1; gnt1; hug-br1; udp-glucuronosyltransferase 1-1; udpglucuronosyltransferase 1-a; udp-glucuronosyltransferase 1a1; udpgt 1-1; ugt-1a; ugt1; ugt1*1; ugt1-01; ugt1.1; ugt1a; ugt1a1

Target Uniprot ID

p35503 + p54855 + p22309

Target, Subunit, Species

UDP-glucuronosyltransferase 1-3 [human]; UDP-glucuronosyltransferase 2B15 [human]; UDPglucuronosyltransferase 1-1 [human]

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 1-3 [human]:Wild; UDP-glucuronosyltransferase 2B15 [human]:Wild; UDP-glucuronosyltransferase 1-1 [human]:Wild

Target Species (Bioactivity)

human; human; human

Target Transfection

Non Transfected; Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI ID

human

Organs/Tissues

jejunum

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

100 µM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

35.7

Measurement pX

3.74

Metabolite RN

7962987

Metabolite name

SCH 60663

Concomitants: Compound RN

78881; 85594; 24143771; 1098229; 7981967

Concomitants: Compound name

Uridine 5'-diphosphoglucuronic acid; Saccharo-1,4-lactone; Alamethicin; Methanol; [14C]-Ezetimibe

Concomitants: Compound role

COM; COM; COM; SLV; SUB

Target Name

UDP-glucuronosyltransferase 1-3 [human]; UDP-glucuronosyltransferase 2B15 [human]; UDPglucuronosyltransferase 1-1 [human]

Target Synonyms

gnt1; udp-glucuronosyltransferase 1-3; udp-glucuronosyltransferase 1-c; udp-glucuronosyltransferase 1a3; udpgt 1-3; ugt-1c; ugt1; ugt1*3; ugt1-03; ugt1.3; ugt1a3; ugt1c + hlug4; udp-glucuronosyltransferase 2b15; udp-glucuronosyltransferase 2b8; udpgt 2b15; udpgt 2b8; udpgth-3; ugt2b15; ugt2b8 + bilirubin-specific udpgt isozyme 1; gnt1; hug-br1; udp-glucuronosyltransferase 1-1; udpglucuronosyltransferase 1-a; udp-glucuronosyltransferase 1a1; udpgt 1-1; ugt-1a; ugt1; ugt1*1; ugt1-01; ugt1.1; ugt1a; ugt1a1

Target Uniprot ID

p35503 + p54855 + p22309

Target, Subunit, Species

UDP-glucuronosyltransferase 1-3 [human]; UDP-glucuronosyltransferase 2B15 [human]; UDPglucuronosyltransferase 1-1 [human]

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 1-3 [human]:Wild; UDP-glucuronosyltransferase 2B15 [human]:Wild; UDP-glucuronosyltransferase 1-1 [human]:Wild

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662 of 976

Target Species (Bioactivity)

human; human; human

Target Transfection

Non Transfected; Non Transfected; Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI ID

human

Organs/Tissues

jejunum

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

200 µM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

52.6

Measurement pX

3.74

Metabolite RN

7962987

Metabolite name

SCH 60663

Concomitants: Compound RN

78881; 85594; 24143771; 1098229; 7981967

Concomitants: Compound name

Uridine 5'-diphosphoglucuronic acid; Saccharo-1,4-lactone; Alamethicin; Methanol; [14C]-Ezetimibe

Concomitants: Compound role

COM; COM; COM; SLV; SUB

Target Name

UDP-glucuronosyltransferase 2B7 [human]

Target Synonyms

3,4-catechol estrogen-specific udpgt; udp-glucuronosyltransferase 2b7; udp-glucuronosyltransferase 2b9; udpgt 2b7; udpgt 2b9; udpgth-2; ugt2b7; ugtb2b9

Target Uniprot ID

p16662

Target PDB ID

2o6l

Target, Subunit, Species

UDP-glucuronosyltransferase 2B7 [human]

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 2B7 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI ID

human

Organs/Tissues

jejunum

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

100 µM

Measurement Parameter

% Inhibition

Unit

%

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663 of 976

664 of 976

Quantitative value

21.3

Measurement pX

1

Metabolite RN

24459560

Metabolite name

SCH 488128

Concomitants: Compound RN

78881; 85594; 24143771; 1098229; 7981967

Concomitants: Compound name

Uridine 5'-diphosphoglucuronic acid; Saccharo-1,4-lactone; Alamethicin; Methanol; [14C]-Ezetimibe

Concomitants: Compound role

COM; COM; COM; SLV; SUB

Target Name

UDP-glucuronosyltransferase 2B7 [human]

Target Synonyms

3,4-catechol estrogen-specific udpgt; udp-glucuronosyltransferase 2b7; udp-glucuronosyltransferase 2b9; udpgt 2b7; udpgt 2b9; udpgth-2; ugt2b7; ugtb2b9

Target Uniprot ID

p16662

Target PDB ID

2o6l

Target, Subunit, Species

UDP-glucuronosyltransferase 2B7 [human]

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 2B7 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI ID

human

Organs/Tissues

jejunum

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

200 µM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

44.2

Measurement pX

3.6

Metabolite RN

24459560

Metabolite name

SCH 488128

Concomitants: Compound RN

78881; 85594; 24143771; 1098229; 7981967

Concomitants: Compound name

Uridine 5'-diphosphoglucuronic acid; Saccharo-1,4-lactone; Alamethicin; Methanol; [14C]-Ezetimibe

Concomitants: Compound role

COM; COM; COM; SLV; SUB

Target Name

UDP-glucuronosyltransferase 2B7 [human]

Target Synonyms

3,4-catechol estrogen-specific udpgt; udp-glucuronosyltransferase 2b7; udp-glucuronosyltransferase 2b9; udpgt 2b7; udpgt 2b9; udpgth-2; ugt2b7; ugtb2b9

Target Uniprot ID

p16662

Target PDB ID

2o6l

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665 of 976

Target, Subunit, Species

UDP-glucuronosyltransferase 2B7 [human]

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 2B7 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Cells/Cell Lines

cells

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

200 µM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

82.8

Measurement pX

4.38

Metabolite RN

24459560

Metabolite name

SCH 488128

Concomitants: Compound RN

78881; 85594; 24143771; 7981967

Concomitants: Compound name

Uridine 5'-diphosphoglucuronic acid; Saccharo-1,4-lactone; Alamethicin; [14C]-Ezetimibe

Concomitants: Compound role

COM; COM; COM; SUB

Target Name

UDP-glucuronosyltransferase 2B15 [human]

Target Synonyms

hlug4; udp-glucuronosyltransferase 2b15; udp-glucuronosyltransferase 2b8; udpgt 2b15; udpgt 2b8; udpgth-3; ugt2b15; ugt2b8

Target Uniprot ID

p54855

Target, Subunit, Species

UDP-glucuronosyltransferase 2B15 [human]

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 2B15 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Cells/Cell Lines

cells

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

200 µM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

96.9

Measurement pX

4.98

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666 of 976

667 of 976

Metabolite RN

7962987

Metabolite name

SCH 60663

Concomitants: Compound RN

78881; 85594; 24143771; 7981967

Concomitants: Compound name

Uridine 5'-diphosphoglucuronic acid; Saccharo-1,4-lactone; Alamethicin; [14C]-Ezetimibe

Concomitants: Compound role

COM; COM; COM; SUB

Target Name

Aldehyde oxidase [human]

Target Synonyms

aldehyde oxidase 1; aldehyde oxidase; ao; aox1; azaheterocycle hydroxylase

Target Uniprot ID

q06278

Target PDB ID

4uhw; 4uhx; 5epg

Target, Subunit, Species

Aldehyde oxidase [human]

Target Mutant/Chimera Details

Aldehyde oxidase [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Cytosol

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

50 µM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

49

Measurement pX

4.28

Metabolite RN

3654

Metabolite name

1-Phthalazinone

Concomitants: Compound RN

109240; 506008; 1716295

Concomitants: Compound name

Phthlazine; DMSO; EDTA

Concomitants: Compound role

SUB; SLV; COM

Substance Effect

Behavioural Symptoms

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Effect : discriminative stimulus effectsBioassay : DR: drug responding ( percent responding on flumazenil lever); control response rate represents average of five saline sessions immediately preceding a test; flumazenil 0.32 mg/kg for three monkeys or 0.1 mg/kg for two monkeys diazepam-treated flumazenil discriminating monkeys (training cycles) injected with title comp. during first minute of first test cycle followed by cumulative doses of flumazenil during subsequent cycles; percent DR and response rate ( percent of control) calculated

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Biological Species/NCBI ID

rhesus monkey

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.320000 mg/kg

Substance Route of Adm.

subcutaneous administration

Qualitative Results

title comp. occasioned primarily vehicle-lever responding and attenuated the flumazenil discriminative stimulus, shifted flumazenil dose-effect curve to right, and did not substantially modify response rate

Measurement Parameter

Qualitative

McMahon, Lance R.; France, Charles P.; Journal of Pharmacology and Experimental Therapeutics; vol. 304; nb. 1; (2003); p. 109 - 120, View in Reaxys 668 of 976

Substance Effect

Behavioural Symptoms

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Effect : discriminative stimulus effectsBioassay : DR: drug responding ( percent responding on midazolam lever); control response rate represents average of five saline sessions immediately preceding a test; substitution for midazolam was defined as >= 80 percent responding on midazolamappropriate lever midazolam discriminating monkeys (midazolam training cycles) injected with title comp. during first minute of first test cycle followed by saline or sham injection on subsequent cycles; percent DR and response rate ( percent of control) calculated

Biological Species/NCBI ID

rhesus monkey

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.0100000 mg/kg

Substance Route of Adm.

subcutaneous administration

Qualitative Results

single dose of title comp. (0.032 and 0.1 mg/kg) increased midazolam-lever responding across cycles in a time-related manner (substitution for midazolam was observed within 30 min) and did not substantially modify response rate

Measurement Parameter

Qualitative

McMahon, Lance R.; France, Charles P.; Journal of Pharmacology and Experimental Therapeutics; vol. 304; nb. 1; (2003); p. 109 - 120, View in Reaxys 669 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology stimulation

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Biological Species/NCBI ID

670 of 976

671 of 976

Escherichia coli Topp3

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

100 µM

Measurement Parameter

Fold-increase

Quantitative value

1.41

Metabolite RN

210932

Metabolite name

7-Hydroxy-4-(trifluoromethyl)coumarin

Concomitants: Compound RN

8706346; 77911

Concomitants: Compound name

7-Benzyloxy-4-trifluoromethylcoumarin; NADPH

Concomitants: Compound role

SUB; COE

Target Name

Cytochrome P450 3A4 [chimpanzee]

Target Synonyms

cytochrome p450 3a4

Target, Subunit, Species

Cytochrome P450 3A4 [chimpanzee]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [chimpanzee]:Wild

Target Species (Bioactivity)

chimpanzee

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology stimulation

Biological Species/NCBI ID

Escherichia coli Topp3

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

100 µM

Measurement Parameter

Fold-increase

Quantitative value

1.55

Metabolite RN

210932

Metabolite name

7-Hydroxy-4-(trifluoromethyl)coumarin

Concomitants: Compound RN

8706346; 77911

Concomitants: Compound name

7-Benzyloxy-4-trifluoromethylcoumarin; NADPH

Concomitants: Compound role

SUB; COE

Target Name

GABA-A receptor [taurine cattle]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [taurine cattle]

Target Mutant/Chimera Details

GABA-A receptor [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

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672 of 976

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

taurine cattle

Organs/Tissues

brain cortex

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

5.17

Deviation

0.200000

Measurement pX

8.29

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

Concomitants: Compound role

NSB; RAD

Target Name

ionotropic gamma aminobutyric acid a receptor [human]

Target Synonyms

ionotropic gamma aminobutyric acid a receptor

Target, Subunit, Species

ionotropic gamma aminobutyric acid a receptor [human]

Target Mutant/Chimera Details

ionotropic gamma aminobutyric acid a receptor [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

human

Organs/Tissues

brain cortex

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

6.5

Deviation

0.500000

Measurement pX

8.19

Concomitants: Compound RN

754371; 4763661

Concomitants: Compound name

Diazepam; [3H]-Ro 15-1788

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673 of 976

Concomitants: Compound role

NSB; RAD

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

no effect on the response to GABA (field-stimulated guinea-pig vas deferens preparation; dose: 1E-5 M)

Measurement Parameter

Qualitative

Doble; Turnbull; Journal of Pharmacy and Pharmacology; vol. 33; nb. 4; (1981); p. 267 - 268, View in Reaxys 674 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : drug interactionBioassay : determination of I/Ic ( GABA-induced peak current in the presence of the drug/ control GABA-induced peak current); I/Imax (Imax: maximal current) in vitro; cells from 6-d-old Wistar rats; electrophysiological recording α-aminobutyric acid (GABA)-induced membrane currents; add. of α-aminobutyric acid (GABA, 3 μM) and bicuculline (BIC,100 μM)

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1 µM

Qualitative Results

title comp. potentiated GABA-induced currents

Measurement Parameter

Qualitative

Feigenspan; Bormann; European Journal of Pharmacology - Molecular Pharmacology Section; vol. 288; nb. 1; (1994); p. 97 104, View in Reaxys 675 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : different brain regions of Harlan Sprague-Dawley ratBioassay : region sepcific changes in benzodiazepine binding site labeled by <3H>-title compound in discrete brain regions of rats made tolerant and dependent upon pentobarbital the brain sections of rats (rendered tolerant by intracerebroventricular infusion with pentobarbital (300 μg/10μl/h for 6 d)) incubated with 1 nM <3H>-labeled title compound for 90 min at 4 deg C, pH 7.1; autoradiograms generated

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

in tolerant rats: significant increase in <3H>-title compound binding sites in frontal cortex and olfactory bulb; in dependent rats: increase in frontal cortex, caudate-putamen, olfactory tubercle, olfactory bulb, globus pallidus and ventral pallidum

Measurement Parameter

Qualitative

Suzuki; Ito; Wellman; Ho Ing Kang; Life Sciences; vol. 57; nb. 5; (1995); p. 63 - 69, View in Reaxys 676 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |pharmacokinetics Bioassay : drugs were administered into femoral vein, blood samples taken from the carotid artery of the womb; pharmacokinetic parameters of the transplacental passage were determined

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

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Substance Dose

5 mg/kg

Qualitative Results

half-life of elimination phase: t1/2α2=83.49 min; foetomaternal conc ratio at equilibrium: FMCReq=0.324; time to reach equilibrium: teq=37.67 min

Measurement Parameter

Qualitative

Staud; Fendrich; Kopecka; Palicka; Laznicek; Pharmaceutical Sciences; vol. 2; nb. 4; (1996); p. 195 - 198, View in Reaxys 677 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Bioassay : Wistar rats, membranes prepared from the cerebral cortex, cerebellum and spinal cord, enriched with cholesterol, incubated with phosphatidylcholine liposomes, experiments were performed to determine the binding effects in the presence of pregnanolone

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

the potency of pregnanolone was reduced by a factor of 3.2 in cerebral cortex while increased by a factor of 8.4 in spinal cord by title comp. following cholesterol enrichment, little overall change in cerebellum in pregnanolon potency by title comp.

Measurement Parameter

Qualitative

Bennett; Simmonds; British Journal of Pharmacology; vol. 117; nb. 1; (1996); p. 87 - 92, View in Reaxys 678 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Bioassay : Wistar rats, membranes prepared from the whole brain, enriched with cholesterol, incubated with phosphatidylcholine liposomes, experiments were performed to determine the binding effects in the presence of pregnanolone, propofol, muscimol

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

cholesterol enrichment did not affected the binding of title comp., however, the enhancement of binding by pregnanolone was affected; that of by propofol was reduced in cholesterol-enriched membranes, muscimol was a potentiator of title comp. binding

Measurement Parameter

Qualitative

Bennett; Simmonds; British Journal of Pharmacology; vol. 117; nb. 1; (1996); p. 87 - 92, View in Reaxys 679 of 976

Target Name

Cholecystokinin receptor type A [Rattus norvegicus]

Target Synonyms

cck-a receptor; cck-ar; cck1-r; cckar; cholecystokinin receptor type a; cholecystokinin-1 receptor

Target Uniprot ID

p30551

Target, Subunit, Species

Cholecystokinin receptor type A [Rattus norvegicus]

Target Mutant/Chimera Details

Cholecystokinin receptor type A [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Sprague Dawley rat

Organs/Tissues

pancreas

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680 of 976

681 of 976

Substance RN

702691View in Reaxys

Substance Name

flunirazepam

Measurement Parameter

IC50

Unit

µM

Qualitative value

>

Quantitative value

100

Measurement pX

1

Concomitants: Compound RN

1719757

Concomitants: Compound name

Dithiothreitol

Concomitants: Compound role

COM

Target Name

Gastrin/cholecystokinin type B receptor [guinea pig]

Target Synonyms

gastrin/cholecystokinin type b receptor

Target, Subunit, Species

Gastrin/cholecystokinin type B receptor [guinea pig]

Target Mutant/Chimera Details

Gastrin/cholecystokinin type B receptor [guinea pig]:Wild

Target Species (Bioactivity)

guinea pig

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

guinea pig

Organs/Tissues

brain cortex

Substance RN

702691View in Reaxys

Substance Name

flunirazepam

Measurement Parameter

IC50

Unit

µM

Qualitative value

>

Quantitative value

100

Measurement pX

1

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

brain

Substance RN

702691View in Reaxys

Substance Name

flunirazepam

Measurement Parameter

IC50

Unit

µM

Quantitative value

0.0017

Measurement pX

8.77

Concomitants: Compound RN

754371

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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682 of 976

Concomitants: Compound name

[3H]-Diazepam

Concomitants: Compound role

RAD

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Organs/Tissues

brain

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

2.4

Measurement pX

8.62

Concomitants: Compound RN

702691; 702691

Concomitants: Compound name

Flunitrazepam; [3H]-Flunitrazepam

Concomitants: Compound role

NSB; RAD

Dorow; Seidler; Schneider; British Journal of Clinical Pharmacology; vol. 13; nb. 4; (1982); p. 561 - 565, View in Reaxys 683 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Healthy

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg

Substance Route of Adm.

oral administration

Substance Dosing Regimen

Single

Measurement Parameter

kel

Unit

h-1

Quantitative value

0.031

Deviation

0.00800000

Dorow; Seidler; Schneider; British Journal of Clinical Pharmacology; vol. 13; nb. 4; (1982); p. 561 - 565, View in Reaxys 684 of 976

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI ID

human

Population State

Healthy

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

2 mg

Substance Route of Adm.

oral administration

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Substance Dosing Regimen

Single

Measurement Parameter

t1/2 el

Unit

hour

Quantitative value

23

Dorow; Seidler; Schneider; British Journal of Clinical Pharmacology; vol. 13; nb. 4; (1982); p. 561 - 565, View in Reaxys 685 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

Vmax

Unit

nmol/min/mg protein

Quantitative value

0.4

Deviation

0.0300000

Metabolite RN

1226636; 568966; 688458; 713494

Metabolite name

4-Hydroxyalprazolam; alpha-Hydroxyalprazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Galetin, Aleksandra; Houston, J. Brian; Journal of Pharmacology and Experimental Therapeutics; vol. 318; nb. 3; (2006); p. 1220 - 1229, View in Reaxys 686 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

375/493

2018-04-14 18:48:42


Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

Vmax

Unit

nmol/min/mg protein

Quantitative value

7.1

Deviation

0.300000

Metabolite RN

1226636; 568966; 688458; 713494

Metabolite name

4-Hydroxyalprazolam; alpha-Hydroxyalprazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Galetin, Aleksandra; Houston, J. Brian; Journal of Pharmacology and Experimental Therapeutics; vol. 318; nb. 3; (2006); p. 1220 - 1229, View in Reaxys 687 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

376/493

2018-04-14 18:48:42


Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

S50

Unit

µM

Quantitative value

300

Deviation

24

Metabolite RN

1226636; 568966; 688458; 713494

Metabolite name

4-Hydroxyalprazolam; alpha-Hydroxyalprazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Galetin, Aleksandra; Houston, J. Brian; Journal of Pharmacology and Experimental Therapeutics; vol. 318; nb. 3; (2006); p. 1220 - 1229, View in Reaxys 688 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

S50

Unit

µM

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

377/493

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Quantitative value

174

Deviation

29

Metabolite RN

1226636; 568966; 688458; 713494

Metabolite name

4-Hydroxyalprazolam; alpha-Hydroxyalprazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Galetin, Aleksandra; Houston, J. Brian; Journal of Pharmacology and Experimental Therapeutics; vol. 318; nb. 3; (2006); p. 1220 - 1229, View in Reaxys 689 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

Clmax

Unit

µL/min/mg protein

Quantitative value

1.4

Metabolite RN

1226636; 568966; 688458; 713494

Metabolite name

4-Hydroxyalprazolam; alpha-Hydroxyalprazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

378/493

2018-04-14 18:48:42


Galetin, Aleksandra; Houston, J. Brian; Journal of Pharmacology and Experimental Therapeutics; vol. 318; nb. 3; (2006); p. 1220 - 1229, View in Reaxys 690 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

Clmax

Unit

µL/min/mg protein

Quantitative value

12

Metabolite RN

1226636; 568966; 688458; 713494

Metabolite name

4-Hydroxyalprazolam; alpha-Hydroxyalprazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Galetin, Aleksandra; Houston, J. Brian; Journal of Pharmacology and Experimental Therapeutics; vol. 318; nb. 3; (2006); p. 1220 - 1229, View in Reaxys 691 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

379/493

2018-04-14 18:48:42


Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

Clmax

Unit

µL/min/pmol target

Quantitative value

0.08

Metabolite RN

1226636; 568966; 713494

Metabolite name

4-Hydroxyalprazolam; alpha-Hydroxyalprazolam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Galetin, Aleksandra; Houston, J. Brian; Journal of Pharmacology and Experimental Therapeutics; vol. 318; nb. 3; (2006); p. 1220 - 1229, View in Reaxys 692 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

380/493

2018-04-14 18:48:42


Measurement Parameter

Clmax

Unit

µL/min/nmol target

Quantitative value

0.1

Metabolite RN

688458

Metabolite name

Desmethylflunitrazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Galetin, Aleksandra; Houston, J. Brian; Journal of Pharmacology and Experimental Therapeutics; vol. 318; nb. 3; (2006); p. 1220 - 1229, View in Reaxys 693 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

intestine

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

Vmax

Unit

nmol/min/mg protein

Quantitative value

0.007

Deviation

0.00100000

Metabolite RN

24193057; 576896; 1169840; 497190; 688458; 713494

Metabolite name

(3S)-Hydroxyquinine; alpha-Hydroxytriazolam; 4-Hydroxytriazolam; Oxidized Nifedipine; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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2018-04-14 18:48:42


Concomitants: Compound role

SLV; SLV; COM; COE

Galetin, Aleksandra; Houston, J. Brian; Journal of Pharmacology and Experimental Therapeutics; vol. 318; nb. 3; (2006); p. 1220 - 1229, View in Reaxys 694 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

intestine

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

Vmax

Unit

nmol/min/mg protein

Quantitative value

0.17

Deviation

0.0200000

Metabolite RN

24193057; 576896; 1169840; 497190; 688458; 713494

Metabolite name

(3S)-Hydroxyquinine; alpha-Hydroxytriazolam; 4-Hydroxytriazolam; Oxidized Nifedipine; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Galetin, Aleksandra; Houston, J. Brian; Journal of Pharmacology and Experimental Therapeutics; vol. 318; nb. 3; (2006); p. 1220 - 1229, View in Reaxys 695 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

382/493

2018-04-14 18:48:42


Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

intestine

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

S50

Unit

µM

Quantitative value

458

Deviation

47

Metabolite RN

576896; 1169840; 688458; 713494

Metabolite name

alpha-Hydroxytriazolam; 4-Hydroxytriazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Galetin, Aleksandra; Houston, J. Brian; Journal of Pharmacology and Experimental Therapeutics; vol. 318; nb. 3; (2006); p. 1220 - 1229, View in Reaxys 696 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

intestine

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

S50

Unit

µM

Quantitative value

293

Deviation

60

Metabolite RN

576896; 1169840; 688458; 713494

Metabolite name

alpha-Hydroxytriazolam; 4-Hydroxytriazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Galetin, Aleksandra; Houston, J. Brian; Journal of Pharmacology and Experimental Therapeutics; vol. 318; nb. 3; (2006); p. 1220 - 1229, View in Reaxys 697 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

intestine

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

Clmax

Unit

µL/min/mg protein

Quantitative value

0.01

Metabolite RN

576896; 1169840; 688458; 713494

Metabolite name

alpha-Hydroxytriazolam; 4-Hydroxytriazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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2018-04-14 18:48:42


Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Galetin, Aleksandra; Houston, J. Brian; Journal of Pharmacology and Experimental Therapeutics; vol. 318; nb. 3; (2006); p. 1220 - 1229, View in Reaxys 698 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

intestine

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

Clmax

Unit

µL/min/mg protein

Quantitative value

0.19

Metabolite RN

576896; 1169840; 688458; 713494

Metabolite name

alpha-Hydroxytriazolam; 4-Hydroxytriazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Galetin, Aleksandra; Houston, J. Brian; Journal of Pharmacology and Experimental Therapeutics; vol. 318; nb. 3; (2006); p. 1220 - 1229, View in Reaxys 699 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

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Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

intestine

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

Clmax

Unit

µL/min/pmol target

Quantitative value

0.004

Metabolite RN

576896; 1169840; 688458; 713494

Metabolite name

alpha-Hydroxytriazolam; 4-Hydroxytriazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Galetin, Aleksandra; Houston, J. Brian; Journal of Pharmacology and Experimental Therapeutics; vol. 318; nb. 3; (2006); p. 1220 - 1229, View in Reaxys 700 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

386/493

2018-04-14 18:48:42


Organs/Tissues

intestine

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

Clmax

Unit

µL/min/pmol target

Quantitative value

0.012

Metabolite RN

576896; 1169840; 688458; 713494

Metabolite name

alpha-Hydroxytriazolam; 4-Hydroxytriazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

741857; 1098229; 1727945; 3885115

Concomitants: Compound name

Acetonitrile; Methanol; (+/-)-Isocitric acid; NADP

Concomitants: Compound role

SLV; SLV; COM; COE

Galetin, Aleksandra; Houston, J. Brian; Journal of Pharmacology and Experimental Therapeutics; vol. 318; nb. 3; (2006); p. 1220 - 1229, View in Reaxys 701 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cells/Cell Lines

liver cell

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

Vmax

Unit

pmol/min/1e6 cells

Quantitative value

64

Deviation

36

Metabolite RN

1226636; 568966; 688458; 713494; 751823; 759300

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

387/493

2018-04-14 18:48:42


702 of 976

703 of 976

Metabolite name

4-Hydroxyalprazolam; alpha-Hydroxyalprazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857

Concomitants: Compound name

Acetonitrile

Concomitants: Compound role

SLV

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cells/Cell Lines

liver cell

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

Vmax

Unit

pmol/min/1e6 cells

Quantitative value

11

Deviation

5

Metabolite RN

1226636; 568966; 688458; 713494; 751823; 759300

Metabolite name

4-Hydroxyalprazolam; alpha-Hydroxyalprazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857

Concomitants: Compound name

Acetonitrile

Concomitants: Compound role

SLV

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Target PDB ID

704 of 976

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cells/Cell Lines

liver cell

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

nH

Quantitative value

1.4

Metabolite RN

1226636; 568966; 688458; 713494; 751823; 759300

Metabolite name

4-Hydroxyalprazolam; alpha-Hydroxyalprazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857

Concomitants: Compound name

Acetonitrile

Concomitants: Compound role

SLV

Bioassay Category

Metabolism/Transport

Bioassay Name

Binding

Biological Species/NCBI ID

human

Organs/Tissues

intestine

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Measurement Parameter

fu

Quantitative value

0.94

Galetin, Aleksandra; Houston, J. Brian; Journal of Pharmacology and Experimental Therapeutics; vol. 318; nb. 3; (2006); p. 1220 - 1229, View in Reaxys 705 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

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706 of 976

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cells/Cell Lines

liver cell

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

nH

Quantitative value

1.7

Metabolite RN

1226636; 568966; 688458; 713494; 751823; 759300

Metabolite name

4-Hydroxyalprazolam; alpha-Hydroxyalprazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; N-Desmethyldiazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857

Concomitants: Compound name

Acetonitrile

Concomitants: Compound role

SLV

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cells/Cell Lines

liver cell

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

390/493

2018-04-14 18:48:42


707 of 976

Substance Dose

1 µM

Measurement Parameter

S50

Unit

µM

Quantitative value

76

Deviation

19

Metabolite RN

1226636; 568966; 688458; 713494; 759300

Metabolite name

4-Hydroxyalprazolam; alpha-Hydroxyalprazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857

Concomitants: Compound name

Acetonitrile

Concomitants: Compound role

SLV

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cells/Cell Lines

liver cell

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

S50

Unit

µM

Quantitative value

130

Deviation

86

Metabolite RN

1226636; 568966; 688458; 713494; 759300

Metabolite name

4-Hydroxyalprazolam; alpha-Hydroxyalprazolam; Desmethylflunitrazepam; 3-Hydroxyflunitrazepam; (+/-)-Temazepam

Concomitants: Compound RN

741857

Concomitants: Compound name

Acetonitrile

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

391/493

2018-04-14 18:48:42


Concomitants: Compound role 708 of 976

709 of 976

SLV

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cells/Cell Lines

liver cell

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

% Pathway

Unit

%

Qualitative value

>

Quantitative value

75

Metabolite RN

1226636; 713494

Metabolite name

4-Hydroxyalprazolam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

741857

Concomitants: Compound name

Acetonitrile

Concomitants: Compound role

SLV

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Vmax

Unit

nmol/min/mg protein

Quantitative value

0.29

Deviation

0.200000

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Rawden; Carlile; Tindall; Hallifax; Galetin; Ito; Houston; Xenobiotica; vol. 35; nb. 6; (2005); p. 603 - 625, View in Reaxys 710 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

393/493

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Substance Dose

10 µM

Measurement Parameter

Vmax

Unit

nmol/min/mg protein

Quantitative value

3.2

Deviation

2.20000

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Rawden; Carlile; Tindall; Hallifax; Galetin; Ito; Houston; Xenobiotica; vol. 35; nb. 6; (2005); p. 603 - 625, View in Reaxys 711 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Km

Unit

µM

Quantitative value

248

Deviation

78

Measurement pX

3.61

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

394/493

2018-04-14 18:48:42


Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Rawden; Carlile; Tindall; Hallifax; Galetin; Ito; Houston; Xenobiotica; vol. 35; nb. 6; (2005); p. 603 - 625, View in Reaxys 712 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Km

Unit

µM

Quantitative value

208

Deviation

87

Measurement pX

3.68

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Rawden; Carlile; Tindall; Hallifax; Galetin; Ito; Houston; Xenobiotica; vol. 35; nb. 6; (2005); p. 603 - 625, View in Reaxys 713 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

395/493

2018-04-14 18:48:42


Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

nH

Quantitative value

1.9

Deviation

0.300000

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Rawden; Carlile; Tindall; Hallifax; Galetin; Ito; Houston; Xenobiotica; vol. 35; nb. 6; (2005); p. 603 - 625, View in Reaxys 714 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

396/493

2018-04-14 18:48:42


Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

nH

Quantitative value

1.6

Deviation

0.400000

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Rawden; Carlile; Tindall; Hallifax; Galetin; Ito; Houston; Xenobiotica; vol. 35; nb. 6; (2005); p. 603 - 625, View in Reaxys 715 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Clmax

Unit

µL/min/mg protein

Quantitative value

0.71

Deviation

0.640000

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

397/493

2018-04-14 18:48:42


Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Rawden; Carlile; Tindall; Hallifax; Galetin; Ito; Houston; Xenobiotica; vol. 35; nb. 6; (2005); p. 603 - 625, View in Reaxys 716 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Clmax

Unit

µL/min/mg protein

Quantitative value

5.3

Deviation

4.20000

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Rawden; Carlile; Tindall; Hallifax; Galetin; Ito; Houston; Xenobiotica; vol. 35; nb. 6; (2005); p. 603 - 625, View in Reaxys 717 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Clint

Unit

µL/min/mg protein

Quantitative value

1.394

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Rawden; Carlile; Tindall; Hallifax; Galetin; Ito; Houston; Xenobiotica; vol. 35; nb. 6; (2005); p. 603 - 625, View in Reaxys 718 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology substrate

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

399/493

2018-04-14 18:48:42


Substance Name

Flunitrazepam

Substance Dose

10 µM

Measurement Parameter

Clint

Unit

µL/min/mg protein

Quantitative value

12.9

Metabolite RN

688458; 713494

Metabolite name

Desmethylflunitrazepam; 3-Hydroxyflunitrazepam

Concomitants: Compound RN

1727945; 3885115

Concomitants: Compound name

(+/-)-Isocitric acid; NADP

Concomitants: Compound role

COM; COE

Rawden; Carlile; Tindall; Hallifax; Galetin; Ito; Houston; Xenobiotica; vol. 35; nb. 6; (2005); p. 603 - 625, View in Reaxys 719 of 976

Bioassay Category

Metabolism/Transport

Bioassay Name

Binding

Biological Species/NCBI ID

human

Organs/Tissues

liver

Cell Fraction

Microsome

Substance RN

702691View in Reaxys

Substance Name

Flunitrazepam

Substance Dose

1 µM

Measurement Parameter

fu

Quantitative value

0.94

Rawden; Carlile; Tindall; Hallifax; Galetin; Ito; Houston; Xenobiotica; vol. 35; nb. 6; (2005); p. 603 - 625, View in Reaxys 720 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

significant deterioration of the individual optimal quotient in the driver-vehicle-road system and of steering ability, the increase of the number of errors in technical handling; 2 mg; male and female; orally

Measurement Parameter

Qualitative

Schmidt; Brendemuhl; Dellen; Meurer-Kruell; Helm; Arzneimittel-Forschung/Drug Research; vol. 35; nb. 8; (1985); p. 1336 - 1340, View in Reaxys 721 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

impairement of motor coordination - ED 50: 0.23 mg/kg p.o., induce of muscle relaxation - ED 50: 0.15 mg/kg p.o., 0.5 h, female mice; inhibition of in vitro tritiated flunitrazepam binding, Ki = 4.4 nmol/l, rats

Measurement Parameter

Qualitative

Chambon; Perio; Demarne; et al.; Arzneimittel-Forschung/Drug Research; vol. 35; nb. 10; (1985); p. 1572 - 1577, View in Reaxys

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

400/493

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722 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : potentiation of GABA-gated currentsBioassay : cells prepared from 8-d-old pups; wholecell recordings of inward currents obtained from granule neurons maintained for 8 d in vitro without flumazenil pretreatment then cells treated with 0.3 μM GABA and various concentrations of flumazenil

Biological Species/NCBI ID

Rattus norvegicus

Cells/Cell Lines

granule cell

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1 µM

Qualitative Results

in presence of title comp. + 0.3 μM GABA potentiation of GABA-gated currents were 112 percent, 111 percent, 50 percent and 24 percent without flumazenil, in presence of 20 nM, 1 μM and 10 μM flumazenil, resp.

Measurement Parameter

Qualitative

Zheng; Caruncho; Wei Jian Zhu; Vicini; Ikonomovic; Grayson; Costa; Journal of Pharmacology and Experimental Therapeutics; vol. 277; nb. 1; (1996); p. 525 - 533, View in Reaxys 723 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

loss of palpebral reflex (in 77 s), apnea onset (in 91 s), duration of apnea 114 s, percent of apnea onset 80, no changes in PaO2, increase of PaCO2 and pH, decrease of BE, fall in SAP, DAP, MAP (5 min), decrease of HR (human, 0.03 mg/kg)

Measurement Parameter

Qualitative

Morel; Forster; Gardaz; Suter; Gemperle; Arzneimittel-Forschung/Drug Research; vol. 31; nb. 12 a; (1981); p. 2264 - 2267, View in Reaxys 724 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

immediate fall and then slow increase of BP (hypertonic human, 0.015 mg/kg, i.v. + 1 mg/kg of ketamine)

Measurement Parameter

Qualitative

Langrehr; Erdmann; Arzneimittel-Forschung/Drug Research; vol. 31; nb. 12 a; (1981); p. 2269 - 2273, View in Reaxys 725 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Bioassay Details

Effect : |receptor; binding activity Bioassay : binding assay 5-day-old (newborn) rats decapitated, brains rapidly removed, cerebral cortex dissected; membrane susp. incubated 60 min, 4 deg C in Tris-HCl buffer containing 0.5 nmol/l <3H>flunitrazepam and title comp.

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1.00000E-09 M

Measurement Parameter

IC50

Unit

nM

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Quantitative value

1.52

Measurement pX

8.82

Giorgi; Lecca; Cancedda; Serra; Corda; European Journal of Pharmacology - Molecular Pharmacology Section; vol. 290; nb. 1; (1995); p. 37 - 47, View in Reaxys 726 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Bioassay Details

Effect : |receptor; binding activity Bioassay : binding assay 5-day-old (newborn) rats decapitated, brains removed, cerebral cortex dissected; membrane susp. incubated in Tris-citrate buffer cont. 1.5-3 nmol/l <3H>t-butylbicyclophosphorothionate (<3H>TBPS), 0.1 nmol/l-30 μmol/l <3H>flunitrazepam and title comp.

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1.00000E-10 M

Measurement Parameter

IC50

Unit

nM

Quantitative value

2.46

Measurement pX

8.61

Giorgi; Lecca; Cancedda; Serra; Corda; European Journal of Pharmacology - Molecular Pharmacology Section; vol. 290; nb. 1; (1995); p. 37 - 47, View in Reaxys 727 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Bioassay Details

Effect : |receptor; binding activity Bioassay : binding assay 90-day-old (adult) rats decapitated, brains rapidly removed, cerebral cortex dissected; membrane susp. incubated 60 min, 4 deg C in Tris-HCl buffer containing 0.5 nmol/l <3H>flunitrazepam and title comp.

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1.00000E-09 M

Measurement Parameter

IC50

Unit

nM

Quantitative value

1.37

Measurement pX

8.86

Giorgi; Lecca; Cancedda; Serra; Corda; European Journal of Pharmacology - Molecular Pharmacology Section; vol. 290; nb. 1; (1995); p. 37 - 47, View in Reaxys 728 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Bioassay Details

Effect : |receptor; binding activity Bioassay : binding assay 90-day-old (adult) rats decapitated, brains removed, cerebral cortex dissected; membrane susp. incubated in Tris-citrate buffer cont. 1.5-3 nmol/l <3H>t-butylbicyclophosphorothionate (<3H>TBPS), 0.1 nmol/l-30 μmol/l <3H>flunitrazepam and title comp.

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1.00000E-10 M

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Measurement Parameter

IC50

Unit

nM

Quantitative value

7.62

Measurement pX

8.12

Giorgi; Lecca; Cancedda; Serra; Corda; European Journal of Pharmacology - Molecular Pharmacology Section; vol. 290; nb. 1; (1995); p. 37 - 47, View in Reaxys 729 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : human embryonic kidney cell line 293 (HEK 293)Bioassay : membranes from HEK cells in Tris-citrate buffer (pH 7.4) incubated with various concns. of (3H)-title comp. for 90 min at 4 deg C in absence or presence of 100 μM diazepam; radioactivity measured after rapid filtration

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0 nM

Qualitative Results

binding of (3H)-title comp. increased with increasing concn.; Kd for specific binding above 100 nM; high values for non specific binding

Measurement Parameter

Qualitative

Fuchs; Zezula; Slany; Sieghart; European Journal of Pharmacology - Molecular Pharmacology Section; vol. 289; nb. 1; (1995); p. 87 - 95, View in Reaxys 730 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : transfected human embryonic kidney (HEK) cell line 293Bioassay : transfected cells, with various combinations of plasmids encoding for GABAA receptor subunits, incubated with (3H)-title comp. in presence or absence of 100 μM GABA for 120 min at 4 deg C; results expressed as percent of the experiments without GABA HEK cells transfected with cDNA encoding for rat brain α1-, α3- and α2-subunits of GABAA receptors; polymerase chain reaction (PCR) used for estimation of

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

2 nM

Qualitative Results

binding of (3)H-title comp. to cells transfected with α1,α3,α2 GABAA subunits in presence of GABA 191 percent; not detected in case of α1α3 and α3α2;

Measurement Parameter

Qualitative

Fuchs; Zezula; Slany; Sieghart; European Journal of Pharmacology - Molecular Pharmacology Section; vol. 289; nb. 1; (1995); p. 87 - 95, View in Reaxys 731 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : human embryonic kidney cell line 293 (HEK 293)Bioassay : membranes from HEK cells in Tris-citrate buffer (pH 7.4) incubated with 2 nM (3H)PK 11195 at 4 deg C in absence or presence of 100 μM PK 11195 or various concns. of title comp.

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1.00000E-09 M

Measurement Parameter

IC50

Unit

µM

Quantitative value

8.4

Measurement pX

5.08

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Fuchs; Zezula; Slany; Sieghart; European Journal of Pharmacology - Molecular Pharmacology Section; vol. 289; nb. 1; (1995); p. 87 - 95, View in Reaxys 732 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : human embryonic kidney cell line 293 (HEK 293)Bioassay : membranes from HEK cells in Tris-citrate buffer (pH 7.4) incubated with 2 nM (3H)-title comp. at 4 deg C in absence or presence of 100 μM diazepam or various concns. of title comp.

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1.00000E-09 M

Measurement Parameter

IC50

Unit

nM

Quantitative value

120

Measurement pX

6.92

Fuchs; Zezula; Slany; Sieghart; European Journal of Pharmacology - Molecular Pharmacology Section; vol. 289; nb. 1; (1995); p. 87 - 95, View in Reaxys 733 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : bindingTarget : brain of Sprague-Dawley ratBioassay : autoradiographic anal. of dried slices; ASO - antisense oligodeoxynuclide rats (250-300 g) cannulated, injection of vehicle or gamma-2 ASO (18 μg, every 12 h 3 days) into right i.c.v. space; 6 h after last i.c.v. injection rats killing, brain slices prepn.; preincubation (30 min); incubation with 3H-labeled title compd.

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

5 nM

Qualitative Results

specific binding in various brain tissue areas (dependence on gamma-2 ASO pretreatment) evaluated (diagram)

Measurement Parameter

Qualitative

Zhao, Tai-Jun; Li, Ming; Chiu, Ted H.; Rosenberg, Howard C.; Journal of Pharmacology and Experimental Therapeutics; vol. 287; nb. 2; (1998); p. 752 - 759, View in Reaxys 734 of 976

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Effect : |antagonist Bioassay : chronic treatment: inhalation of title compd. (120 mg/10 l air per min), pyrazole (1.0 mmol/kg/day, i.p.) and title compd. injections mice (30 g) chronically treated (inhalation) with ethanol and title compd. (8 days), withdrawal (8 h); mice decapitated, lysate from cerebral cortex anal. (Northern blot anal., radioimmunoassay)

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

10 mg/kg

Substance Route of Adm.

intraperitoneal administration

Qualitative Results

complete abolishment of increase of diazepam binding inhibitor mRNA level in ethanol treated/ withdrawn mice (diagram)

Measurement Parameter

Qualitative

Katsura; Ohkuma; Tsujimura; Kuriyama; Journal of Pharmacology and Experimental Therapeutics; vol. 273; nb. 3; (1995); p. 1529 - 1533, View in Reaxys 735 of 976

Bioassay Category

In Vitro (Efficacy)

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Bioassay Name

In Vitro (others)

Bioassay Details

Effect : expression of α1 subunit protein of GABAA receptorTarget : primary cerebellar granule cells from Sprague-Dawley ratsBioassay : Western blotting; optical density readings in vitro; cells isolated from post-natal day 8 Sprague-Dawley rats, culture density 6-7E6 cells per 25 cm2, treated with the title comp. at day 8 in vitro, 37 deg C, 2 days, enhanced chemiluminescence used to detect GABAA receptor subunit proteins

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1 nM

Qualitative Results

the level of GABAA receptor α1 subunit protein is significantly reduced (-25+/-4 percent , -58+/-18 percent, -41+/-3 percent for doses 1 nM, 10 nM, 1μM, respectively

Measurement Parameter

Qualitative

Brown, Maria J.; Bristow, David R.; British Journal of Pharmacology; vol. 118; nb. 5; (1996); p. 1103 - 1110, View in Reaxys 736 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : expression of the GABAA α6 subunit proteinTarget : cerebellar granule cells from SpragueDawley ratsBioassay : BME=basal modified Eagle`s medium, ECL=enhanced cheminiluminescence in vitro; 6-7E6 cells per 25 cm2, at day 8 media replaced with supplemented BME with 10 μM cytosine arabinoside and the title comp., 37 deg C, 12 days, cells harvested for protein, western blotting, ECL detection GABAA receptor subunit proteins

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1 µM

Qualitative Results

expression of GABAA receptor α6 subunit protein is not altered by exposure to 1 μM flunitrazepam treatment over a 12 day treatment period

Measurement Parameter

Qualitative

Brown, Maria J.; Bristow, David R.; British Journal of Pharmacology; vol. 118; nb. 5; (1996); p. 1103 - 1110, View in Reaxys 737 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Target : pancreas of pigBioassay : radioactivity counted after filtration; PK-11195: 1-(2-chlorophenyl-N-methyl-1-methyl-propyl)-3-isoquinolinecarboxamide (benzodiazepine receptor ligand) pure islets of Langerhans prepared from the market-age pigs; membrane prepared and 0.05 mg of proteins incubated at 0 deg C with <3H>PK-11195 (0.4 nmol/l) in the presence of 5 to 8 different concentrations of the title comp.

Substance RN

702691View in Reaxys

Substance Name

31870

Qualitative Results

title comp. displaced PK-11195; Ki = 3400 nmol/l (table)

Measurement Parameter

Qualitative

Marchetti, Piero; Trincavelli, Letizia; Giannarelli, Rosa; Giusti, Laura; Coppelli, Alberto; Martini, Claudia; Navalesi, Renzo; Lucacchini, Antonio; Biochemical Pharmacology; vol. 51; nb. 11; (1996); p. 1437 - 1442, View in Reaxys 738 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Binding

Bioassay Details

Effect : |receptor; binding activity Target : P2 cortical membranesBioassay : CBR tested; nonspecific binding determined in the presence of clonazepam; CBR: central-type benzodiazepine receptor in vitro; saturation binding study; <3H>title comp. as radioligand; incubated at 4 deg C for 30 min under 760 μM O2; liquid scintillation counting

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

7 nM

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Qualitative Results

graphical representation

Measurement Parameter

Qualitative

Courtiere; Molard; Reybaud; Biochemical Pharmacology; vol. 50; nb. 11; (1995); p. 1815 - 1822, View in Reaxys 739 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |receptor; binding activity Bioassay : in vitro; saturation binding assay; brain membranes from normal or renal dysfunction rats; <3H>title comp. as radioligand; 50 mmol/l Tris-HCl buffer, pH 7.4; 37 deg C; incub. for 30 min; radioligand binding measured by scintillation counting

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.800000 nM

Measurement Parameter

Kd

Unit

nM

Quantitative value

10.52 - 11.69

Measurement pX

7.98

Srivastava, Kalpana; Hatanaka, Tomomi; Katayama, Kazunori; Koizumi, Tamotsu; Biological and Pharmaceutical Bulletin; vol. 22; nb. 3; (1999); p. 288 - 294, View in Reaxys 740 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : receptor subunit protein expression; inhibition ofTarget : rat primary cerebellar granule cellsBioassay : further investigations on mechanism of action using bisindolylmaleimide and H-89 cells incubated with title comp. at 37 deg C for 10 min or 1 h; cells lysed in denaturating buffer, GABAA receptor α1 and α2/3 subunit protein detected in whole cell extracts measuring protein immunoreactivity in grey-scale units by densitometry

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

1 µM

Qualitative Results

reduction of α1 and α2/3 subunit protein levels by 22 and 21 percent, respectively, via protein kinase C-dependent mechanism (diagram)

Measurement Parameter

Qualitative

Johnston, Jonathan D.; Price, Sally A.; Bristow, David R.; British Journal of Pharmacology; vol. 124; nb. 7; (1998); p. 1338 1340, View in Reaxys 741 of 976

Target Name

GABA-A receptor

Target Synonyms

gaba-a receptor; gaba-a receptor activity; ionotropic gaba receptor

Target, Subunit, Species

GABA-A receptor

Target Mutant/Chimera Details

GABA-A receptor:Wild

Target Transfection

Non Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : GABAA receptor; modulation ofBioassay : GABA: α-aminobutyric acid; GABA EC50 ratio: GABA EC50 in presence of title comp./GABA EC50 without title comp.; control: not CHL- or ECHL-enriched or CHL-depleted; CHL: cholesterol; ECHL: epicholesterol neurons enriched with CHL, ECHL or depleted, attached to patch electrode for whole-cell patch clamp recording; membrane current recorded from somata of neurons, voltage-clamped at -20 mV at ca. 20 deg C; GABA and title comp. added simultaneously

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742 of 976

Biological Species/NCBI ID

Rattus norvegicus

Cells/Cell Lines

nerve cell

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

10 µM

Qualitative Results

GABA EC50 ratio in CHL-depleted (56 percent control), CHL-enriched (182 percent control) and ECHL-incorporated neurons: 0.397, 0.276 and 0.297, resp. (control: 0.477)

Measurement Parameter

Qualitative

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Effect : |pharmacokinetics Bioassay : Cmax: maximum plasma conc.; AUC0-inf: area under conc.time curve from 0 to infinity; Vdα: volume of distribution; CL: plasma clearance title comp. given to 31 neonates and infants (0-438 days) as single 0.2-mg/kg dose (SD, n=28) or multiple doses (MD, 0.2 mg/kg followed by 2-6 doses 0.1 mg/kg, n=3); plasma title comp. conc. measured by GC-MS up to 72 h; pharmacokinetic analysis

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.100000 mg/kg

Substance Route of Adm.

intravenous administration

Qualitative Results

Cmax of title comp. after SD an MD 243 and 161 μg/l, AUC0-inf 2105 and 1454 μg*h/l, Vdα 4.6 and 2.1 l/kg, CL 0.15 and 0.17 l/h/kg, resp.; CL and Vdα sign. increased with postnatal age

Measurement Parameter

Qualitative

Pariente-Khayat, Ann; Treluyer, Jean-Marc; Rey, Elisabeth; Mokhtari, Mostafa; Werner, Evelyne; Jouvet, Philippe; D'Athis, Philippe; Wood, Chantal; Hubert, Philippe; Hotellier, Francoise; Olive, Georges; Pons, Gerard; Clinical Pharmacology and Therapeutics; vol. 66; nb. 2; (1999); p. 136 - 139, View in Reaxys 743 of 976

Substance Effect

Hypotensive

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Bioassay Details

Bioassay : plasma title comp. conc. measured by GC-MS title comp. given to neonates and infants (0-438 days) as single 0.2-mg/kg dose (n=28) or multiple doses (0.2 mg/kg followed by 2-6 doses 0.1 mg/kg, n=3); systolic and diastolic blood pressure (SBP and DBP) and heart rate (HR) recorded up to 72 h

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Substance Name

31870

Substance Dose

0.100000 mg/kg

Substance Route of Adm.

intravenous administration

Qualitative Results

DBP (not SBP and HR) was sign. decreased with increasing title comp. plasma conc.

Measurement Parameter

Qualitative

Pariente-Khayat, Ann; Treluyer, Jean-Marc; Rey, Elisabeth; Mokhtari, Mostafa; Werner, Evelyne; Jouvet, Philippe; D'Athis, Philippe; Wood, Chantal; Hubert, Philippe; Hotellier, Francoise; Olive, Georges; Pons, Gerard; Clinical Pharmacology and Therapeutics; vol. 66; nb. 2; (1999); p. 136 - 139, View in Reaxys 744 of 976

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1

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745 of 976

746 of 976

Target Synonyms

bzrap1; kiaa0612; pbr-ip; peripheral benzodiazepine receptor-interacting protein; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimbp1; rims-binding protein 1; tspo-associated protein 1; tspoap1

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1:Wild

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity of the compound towards benzodiazepine/GABA A receptor

Substance RN

702691View in Reaxys

Measurement Parameter

pIC50

Quantitative value

-0.58

Target Name

Gamma-aminobutyric acid receptor subunit delta;+Gamma-aminobutyric acid receptor subunit beta-2;+Gamma-aminobutyric acid receptor subunit alpha-1

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1; Gamma-aminobutyric acid receptor subunit beta-2; Gamma-aminobutyric acid receptor subunit delta

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta:Wild + Gamma-aminobutyric acid receptor subunit beta-2:Wild + Gamma-aminobutyric acid receptor subunit alpha-1:Wild

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity of the compound towards Gamma-aminobutyric acid A receptor

Substance RN

702691View in Reaxys

Measurement Parameter

pIC50

Quantitative value

-0.58

Target Name

Gamma-aminobutyric acid receptor subunit delta [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]

Target Synonyms

gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gammaaminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p0c2w5 + p08219

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle]; Gamma-aminobutyric acid receptor subunit delta [taurine cattle]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Substance Action on Target

Antagonist

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Ratio of binding affinity of the compound towards cow Central benzodiazepine receptor from cortical membrane without GABA to that of with 50 uM GABA

Biological Species/NCBI ID

taurine cattle

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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747 of 976

748 of 976

Substance RN

702691View in Reaxys

Measurement Parameter

Qualitative

Qualitative value

Not Published

Target Name

Gamma-aminobutyric acid receptor subunit delta [human];+Gamma-aminobutyric acid receptor subunit beta-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

o14764 + p47870 + p14867

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]; Gamma-aminobutyric acid receptor subunit delta [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Antagonist

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Ratio of binding affinity of the compound towards human Central benzodiazepine receptor from cortical membrane without GABA to that of with 50 uM GABA

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Measurement Parameter

Qualitative

Qualitative value

Not Published

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Toxic activity of compound in mice upon oral administration was determined

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Substance Route of Adm.

oral administration

Measurement Parameter

LD50

Unit

mg/kg

Qualitative value

=

Quantitative value

870

Esteki, Mahnaz; Khayamian, Taghi; Chemical Biology and Drug Design; vol. 72; nb. 5; (2008); p. 409 - 435, View in Reaxys 749 of 976

Target Name

Gamma-aminobutyric acid receptor subunit delta [human];+Gamma-aminobutyric acid receptor subunit beta-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

o14764 + p47870 + p14867

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]; Gamma-aminobutyric acid receptor subunit delta [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

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750 of 976

751 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Efficacy of the compound (1 uM) on percent modulation of human GABAA receptor alpha1beta1epsilon EC20 currents expressed in xenopus oocytes

Biological Species/NCBI ID

human

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Measurement Parameter

%

Unit

%

Measurement Object

Modulation

Qualitative value

=

Quantitative value

0

Deviation

0

Target Name

Gamma-aminobutyric acid receptor subunit delta [human];+Gamma-aminobutyric acid receptor subunit beta-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

o14764 + p47870 + p14867

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]; Gamma-aminobutyric acid receptor subunit delta [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity of compound towards human GABAA receptor alpha2beta3gamma2s expressed in xenopus oocytes

Biological Species/NCBI ID

human

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Measurement Parameter

Ki

Unit

nM

Qualitative value

=

Quantitative value

2.2

Measurement pX

8.66

Target Name

Gamma-aminobutyric acid receptor subunit delta [human];+Gamma-aminobutyric acid receptor subunit beta-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

o14764 + p47870 + p14867

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]; Gamma-aminobutyric acid receptor subunit delta [human]

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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752 of 976

753 of 976

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Efficacy of the compound (100 x Ki) on percent modulation of human GABAA receptor alpha2beta3gamma2s EC20 currents expressed in xenopus oocytes

Biological Species/NCBI ID

human

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Measurement Parameter

%

Unit

%

Measurement Object

Modulation

Qualitative value

=

Quantitative value

121

Deviation

9.3

Target Name

Cytochrome P450 2B2 [Rattus norvegicus]

Target Synonyms

cyp2b-2; cyp2b2; cypiib2; cytochrome p450 2b2; cytochrome p450 pb4; cytochrome p450e

Target Uniprot ID

p04167

Target, Subunit, Species

Cytochrome P450 2B2 [Rattus norvegicus]

Target Mutant/Chimera Details

Cytochrome P450 2B2 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Bioassay Category

Metabolism/Transport

Bioassay Details

Half maximal activation of PBRU-dependent transcription of a luc expression vector under control of 2.5kb of the CYP2B2 5'-flank, transfected in primary rat hepatocytes upon 48 hr treatment in serum free medium by measuring luciferase activity using Promega dual luciferase kit

Biological Species/NCBI ID

Rattus norvegicus

Cells/Cell Lines

liver cell

Substance RN

702691View in Reaxys

Measurement Parameter

EC50

Unit

µM

Measurement Object

Half maximal activation

Qualitative value

=

Quantitative value

5.7

Deviation

0.5

Measurement pX

5.24

Target Name

Gamma-aminobutyric acid receptor subunit delta;+Gamma-aminobutyric acid receptor subunit beta-2;+Gamma-aminobutyric acid receptor subunit alpha-1

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1; Gamma-aminobutyric acid receptor subunit beta-2; Gamma-aminobutyric acid receptor subunit delta

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Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta:Wild + Gamma-aminobutyric acid receptor subunit beta-2:Wild + Gamma-aminobutyric acid receptor subunit alpha-1:Wild

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Inhibition constant of the compound against GABAA receptor in C57BL/6J brain membrane in mouse upon incubation for 90 min at 4 degree C using 50 mM Tris/citrate buffer (pH 7.1) and 5 nM [3H]flunitrazepam radioligand

Substance RN

702691View in Reaxys

Measurement Parameter

Ki

Unit

nM

Qualitative value

=

Quantitative value

7.2

Deviation

0.8

Measurement pX

8.14

Concomitants: Compound name

[3H]Flunitrazepam

Concomitants: Compound role

RAD

Ogris, Waltraud; Poeltl, Angelika; Hauer, Birgit; Ernst, Margot; Oberto, Alessandra; Wulff, Peer; Hoeger, Harald; Wisden, William; Sieghart, Werner; Biochemical Pharmacology; vol. 68; nb. 8; (2004); p. 1621 - 1629, View in Reaxys 754 of 976

Target Name

Gamma-aminobutyric acid receptor subunit delta;+Gamma-aminobutyric acid receptor subunit beta-2;+Gamma-aminobutyric acid receptor subunit alpha-1

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1; Gamma-aminobutyric acid receptor subunit beta-2; Gamma-aminobutyric acid receptor subunit delta

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta:Wild + Gamma-aminobutyric acid receptor subunit beta-2:Wild + Gamma-aminobutyric acid receptor subunit alpha-1:Wild

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Dissociation constant of the compound radiolabeled compound with [3H]for GABAA receptor in C57BL/6J brain membrane in mouse

Substance RN

702691View in Reaxys

Measurement Parameter

Kd

Unit

nM

Measurement Object

Dissociation constant

Qualitative value

=

Quantitative value

7.9

Deviation

0.2

Measurement pX

8.1

Ogris, Waltraud; Poeltl, Angelika; Hauer, Birgit; Ernst, Margot; Oberto, Alessandra; Wulff, Peer; Hoeger, Harald; Wisden, William; Sieghart, Werner; Biochemical Pharmacology; vol. 68; nb. 8; (2004); p. 1621 - 1629, View in Reaxys 755 of 976

Target Name

Gamma-aminobutyric acid receptor subunit delta;+Gamma-aminobutyric acid receptor subunit beta-2;+Gamma-aminobutyric acid receptor subunit alpha-1

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1; Gamma-aminobutyric acid receptor subunit beta-2; Gamma-aminobutyric acid receptor subunit delta

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta:Wild + Gamma-aminobutyric acid receptor subunit beta-2:Wild + Gamma-aminobutyric acid receptor subunit alpha-1:Wild

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Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding maximum of the [3H] radiolabeled compound towards GABAA receptor in gamma2F77I brain membrane in mouse

Substance RN

702691View in Reaxys

Qualitative Results

Binding maximum (Bmax)

Measurement Object

Binding maximum

Ogris, Waltraud; Poeltl, Angelika; Hauer, Birgit; Ernst, Margot; Oberto, Alessandra; Wulff, Peer; Hoeger, Harald; Wisden, William; Sieghart, Werner; Biochemical Pharmacology; vol. 68; nb. 8; (2004); p. 1621 - 1629, View in Reaxys 756 of 976

Target Name

Gamma-aminobutyric acid receptor subunit delta;+Gamma-aminobutyric acid receptor subunit beta-2;+Gamma-aminobutyric acid receptor subunit alpha-1

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1; Gamma-aminobutyric acid receptor subunit beta-2; Gamma-aminobutyric acid receptor subunit delta

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta:Wild + Gamma-aminobutyric acid receptor subunit beta-2:Wild + Gamma-aminobutyric acid receptor subunit alpha-1:Wild

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding maximum of the [3H] radiolabeled compound towards GABAA receptor in C57BL/6J brain membrane in mouse

Substance RN

702691View in Reaxys

Qualitative Results

Binding maximum (Bmax)

Measurement Object

Binding maximum of the [3H] radiolabeled compound towards GABAA receptor

Ogris, Waltraud; Poeltl, Angelika; Hauer, Birgit; Ernst, Margot; Oberto, Alessandra; Wulff, Peer; Hoeger, Harald; Wisden, William; Sieghart, Werner; Biochemical Pharmacology; vol. 68; nb. 8; (2004); p. 1621 - 1629, View in Reaxys 757 of 976

Target Name

Gamma-aminobutyric acid receptor subunit delta;+Gamma-aminobutyric acid receptor subunit beta-2;+Gamma-aminobutyric acid receptor subunit alpha-1

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1; Gamma-aminobutyric acid receptor subunit beta-2; Gamma-aminobutyric acid receptor subunit delta

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta:Wild + Gamma-aminobutyric acid receptor subunit beta-2:Wild + Gamma-aminobutyric acid receptor subunit alpha-1:Wild

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Dissociation constant of radiolabbled compound radiolabeled with [3H] towards GABAA receptor in C57BL/6J brain membrane in mouse

Substance RN

702691View in Reaxys

Measurement Parameter

Kd

Unit

nM

Measurement Object

Dissociation constant

Qualitative value

=

Quantitative value

3.8

Deviation

0.4

Measurement pX

8.42

Ogris, Waltraud; Poeltl, Angelika; Hauer, Birgit; Ernst, Margot; Oberto, Alessandra; Wulff, Peer; Hoeger, Harald; Wisden, William; Sieghart, Werner; Biochemical Pharmacology; vol. 68; nb. 8; (2004); p. 1621 - 1629, View in Reaxys

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758 of 976

Target Name

Gamma-aminobutyric acid receptor subunit delta;+Gamma-aminobutyric acid receptor subunit beta-2;+Gamma-aminobutyric acid receptor subunit alpha-1

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1; Gamma-aminobutyric acid receptor subunit beta-2; Gamma-aminobutyric acid receptor subunit delta

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta:Wild + Gamma-aminobutyric acid receptor subunit beta-2:Wild + Gamma-aminobutyric acid receptor subunit alpha-1:Wild

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Ratio of inhibition constant against GABAA receptor in C57BL/6J to that of gamma2F77I in mouse brain membrane upon incubation for 90 min at 4 degree C using 50 mM Tris/citrate buffer (pH 7.1) and 5 nM [3H]flunitrazepam radioligand

Substance RN

702691View in Reaxys

Measurement Parameter

Qualitative

Measurement Object

Ratio of inhibition constant

Qualitative value

Not Published

Concomitants: Compound name

[3H]Flunitrazepam

Concomitants: Compound role

RAD

Ogris, Waltraud; Poeltl, Angelika; Hauer, Birgit; Ernst, Margot; Oberto, Alessandra; Wulff, Peer; Hoeger, Harald; Wisden, William; Sieghart, Werner; Biochemical Pharmacology; vol. 68; nb. 8; (2004); p. 1621 - 1629, View in Reaxys 759 of 976

Target Name

Gamma-aminobutyric acid receptor subunit delta;+Gamma-aminobutyric acid receptor subunit beta-2;+Gamma-aminobutyric acid receptor subunit alpha-1

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1; Gamma-aminobutyric acid receptor subunit beta-2; Gamma-aminobutyric acid receptor subunit delta

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta:Wild + Gamma-aminobutyric acid receptor subunit beta-2:Wild + Gamma-aminobutyric acid receptor subunit alpha-1:Wild

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Inhibition constant of the compound against GABAA receptor in gamma2F77I brain membrane in mouse upon incubation for 90 min at 4 degree C using 50 mM Tris/citrate buffer (pH 7.1) and 5 nM [3H]flunitrazepam radioligand

Substance RN

702691View in Reaxys

Measurement Parameter

Ki

Unit

nM

Qualitative value

=

Quantitative value

18

Deviation

0.4

Measurement pX

7.74

Concomitants: Compound name

[3H]Flunitrazepam

Concomitants: Compound role

RAD

Ogris, Waltraud; Poeltl, Angelika; Hauer, Birgit; Ernst, Margot; Oberto, Alessandra; Wulff, Peer; Hoeger, Harald; Wisden, William; Sieghart, Werner; Biochemical Pharmacology; vol. 68; nb. 8; (2004); p. 1621 - 1629, View in Reaxys

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760 of 976

761 of 976

762 of 976

763 of 976

Target Name

Cytochrome P450 3A5

Target Synonyms

6-beta-testosterone hydroxylase; cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 fa; cytochrome p450 hlp2; cytochrome p450-pcn3

Target, Subunit, Species

Cytochrome P450 3A5

Target Mutant/Chimera Details

Cytochrome P450 3A5:Wild

Bioassay Category

Metabolism/Transport

Bioassay Details

Ratio of maximal velocity of the compound for 3-Hydroxylation reaction mediated by Cytochrome P450 3A5 to that of Cytochrome P450 3A4 from Baculovirus-infected insect cells

Substance RN

702691View in Reaxys

Measurement Parameter

Ratio

Quantitative value

1.8

Target Name

Cytochrome P450 3A5

Target Synonyms

6-beta-testosterone hydroxylase; cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 fa; cytochrome p450 hlp2; cytochrome p450-pcn3

Target, Subunit, Species

Cytochrome P450 3A5

Target Mutant/Chimera Details

Cytochrome P450 3A5:Wild

Bioassay Category

Metabolism/Transport

Bioassay Details

Maximal velocity of the compound for N-Demethylation reaction mediated by Cytochrome P450 3A5 from Baculovirus-infected insect cells

Substance RN

702691View in Reaxys

Qualitative Results

Vmax not calculated

Measurement Parameter

Qualitative

Measurement Object

Vmax

Target Name

Cytochrome P450 3A4

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target, Subunit, Species

Cytochrome P450 3A4

Target Mutant/Chimera Details

Cytochrome P450 3A4:Wild

Bioassay Category

Metabolism/Transport

Bioassay Details

Intrinsic clearance of the compound for N-Demethylation reaction mediated by Cytochrome P450 3A4 from Baculovirus-infected insect cells

Substance RN

702691View in Reaxys

Measurement Parameter

Clint

Unit

µL/min/nmol P450 all

Quantitative value

0.9

Bioassay Category

Metabolism/Transport

Bioassay Details

Unbound fraction of the compound in cat plasma

Biological Species/NCBI ID

domestic cat

Substance RN

702691View in Reaxys

Measurement Parameter

Activity

Quantitative value

0.32

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

415/493

2018-04-14 18:48:42


Lin, Jiunn H.; Current Drug Metabolism; vol. 9; nb. 1; (2008); p. 46 - 59, View in Reaxys 764 of 976

765 of 976

766 of 976

Target Name

Cytochrome P450 3A4

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target, Subunit, Species

Cytochrome P450 3A4

Target Mutant/Chimera Details

Cytochrome P450 3A4:Wild

Bioassay Category

Metabolism/Transport

Bioassay Details

Intrinsic clearance of the compound for 3-Hydroxylation reaction mediated by Cytochrome P450 3A4 from Baculovirus-infected insect cells

Substance RN

702691View in Reaxys

Measurement Parameter

Clint

Unit

µL/min/nmol P450 all

Quantitative value

5.7

Target Name

Cytochrome P450 3A5

Target Synonyms

6-beta-testosterone hydroxylase; cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 fa; cytochrome p450 hlp2; cytochrome p450-pcn3

Target, Subunit, Species

Cytochrome P450 3A5

Target Mutant/Chimera Details

Cytochrome P450 3A5:Wild

Bioassay Category

Metabolism/Transport

Bioassay Details

Michaelis-Menten constant of the compound for 3-Hydroxylation mediated by Cytochrome P450 3A5 from Baculovirus-infected insect cells

Substance RN

702691View in Reaxys

Measurement Parameter

Km

Unit

µM

Qualitative value

=

Quantitative value

337

Measurement pX

3.47

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Synonyms

bzrap1; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimsbinding protein 1; tspo-associated protein 1; tspoap1

Target Uniprot ID

q9jir0

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Inhibitory concentration against rat spinal cord benzodiazepine receptor by displacing [3H]RoI5-1788 (0.5 nM) with the compound upon incubation for 90 min

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

spinal cord

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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767 of 976

768 of 976

769 of 976

Substance RN

702691View in Reaxys

Measurement Parameter

IC50

Unit

nM

Qualitative value

=

Quantitative value

24

Measurement pX

7.62

Concomitants: Compound name

[3H]Ro 15-1788

Concomitants: Compound role

RAD

Target Name

Cytochrome P450 3A5

Target Synonyms

6-beta-testosterone hydroxylase; cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 fa; cytochrome p450 hlp2; cytochrome p450-pcn3

Target, Subunit, Species

Cytochrome P450 3A5

Target Mutant/Chimera Details

Cytochrome P450 3A5:Wild

Bioassay Category

Metabolism/Transport

Bioassay Details

Intrinsic clearance of the compound for N-Demethylation reaction mediated by Cytochrome P450 3A5 from Baculovirus-infected insect cells

Substance RN

702691View in Reaxys

Measurement Parameter

Clint

Unit

µL/min/nmol P450 all

Quantitative value

1.09

Target Name

Cytochrome P450 3A5

Target Synonyms

6-beta-testosterone hydroxylase; cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 fa; cytochrome p450 hlp2; cytochrome p450-pcn3

Target, Subunit, Species

Cytochrome P450 3A5

Target Mutant/Chimera Details

Cytochrome P450 3A5:Wild

Bioassay Category

Metabolism/Transport

Bioassay Details

Ratio of maximal velocity of the compound for N-Demethylation reaction mediated by Cytochrome P450 3A5 to that of Cytochrome P450 3A4 from Baculovirus-infected insect cells

Substance RN

702691View in Reaxys

Measurement Parameter

Ratio

Quantitative value

0.7

Target Name

Cytochrome P450 3A4

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target, Subunit, Species

Cytochrome P450 3A4

Target Mutant/Chimera Details

Cytochrome P450 3A4:Wild

Bioassay Category

Metabolism/Transport

Bioassay Details

Maximal velocity of the compound for N-Demethylation reaction mediated by Cytochrome P450 3A4 from Baculovirus-infected insect cells

Substance RN

702691View in Reaxys

Qualitative Results

Vmax not calculated

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770 of 976

771 of 976

772 of 976

Measurement Parameter

Qualitative

Measurement Object

Vmax

Target Name

Cytochrome P450 3A5

Target Synonyms

6-beta-testosterone hydroxylase; cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 fa; cytochrome p450 hlp2; cytochrome p450-pcn3

Target, Subunit, Species

Cytochrome P450 3A5

Target Mutant/Chimera Details

Cytochrome P450 3A5:Wild

Bioassay Category

Metabolism/Transport

Bioassay Details

Ratio of intrinsic clearance of the compound for N-Demethylation reaction mediated by Cytochrome P450 3A5 to that of Cytochrome P450 3A4 from Baculovirus-infected insect cells

Substance RN

702691View in Reaxys

Measurement Parameter

Ratio

Quantitative value

1.2

Target Name

Cytochrome P450 3A5

Target Synonyms

6-beta-testosterone hydroxylase; cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 fa; cytochrome p450 hlp2; cytochrome p450-pcn3

Target, Subunit, Species

Cytochrome P450 3A5

Target Mutant/Chimera Details

Cytochrome P450 3A5:Wild

Bioassay Category

Metabolism/Transport

Bioassay Details

Intrinsic clearance of the compound for 3-Hydroxylation reaction mediated by Cytochrome P450 3A5 from Baculovirus-infected insect cells

Substance RN

702691View in Reaxys

Measurement Parameter

Clint

Unit

µL/min/nmol P450 all

Quantitative value

13.4

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Synonyms

bzrap1; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimsbinding protein 1; tspo-associated protein 1; tspoap1

Target Uniprot ID

q9jir0

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity of the compound towards Benzodiazepine receptor type I (BDZR type I) in rat cerebellum was determined

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Measurement Parameter

Ki

Unit

nM

Qualitative value

=

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

418/493

2018-04-14 18:48:42


773 of 976

774 of 976

775 of 976

Quantitative value

1.5

Measurement pX

8.82

Target Name

Cytochrome P450 3A5

Target Synonyms

6-beta-testosterone hydroxylase; cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 fa; cytochrome p450 hlp2; cytochrome p450-pcn3

Target, Subunit, Species

Cytochrome P450 3A5

Target Mutant/Chimera Details

Cytochrome P450 3A5:Wild

Bioassay Category

Metabolism/Transport

Bioassay Details

Michaelis-Menten constant of the compound for N-Demethylation mediated by Cytochrome P450 3A5 from Baculovirus-infected insect cells

Substance RN

702691View in Reaxys

Measurement Parameter

Km

Unit

µM

Qualitative value

=

Quantitative value

128

Measurement pX

3.89

Target Name

Cytochrome P450 3A4

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target, Subunit, Species

Cytochrome P450 3A4

Target Mutant/Chimera Details

Cytochrome P450 3A4:Wild

Bioassay Category

Metabolism/Transport

Bioassay Details

Michaelis-Menten constant of the compound for N-Demethylation mediated by Cytochrome P450 3A4 from Baculovirus-infected insect cells

Substance RN

702691View in Reaxys

Measurement Parameter

Km

Unit

µM

Qualitative value

=

Quantitative value

224

Measurement pX

3.65

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Synonyms

bzrap1; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimsbinding protein 1; tspo-associated protein 1; tspoap1

Target Uniprot ID

q9jir0

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Concentration required to displace 0.5 nM (3H)Ro15-1788 from composite binding sites of benzodiazepine receptor in rat spinal cord upon incubation for 90 min

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776 of 976

777 of 976

778 of 976

Biological Species/NCBI ID

Rattus norvegicus

Organs/Tissues

spinal cord

Substance RN

702691View in Reaxys

Measurement Parameter

IC50

Unit

nM

Qualitative value

=

Quantitative value

24

Measurement pX

7.62

Concomitants: Compound name

[3H]Ro 15-1788

Concomitants: Compound role

RAD

Target Name

Cytochrome P450 3A5

Target Synonyms

6-beta-testosterone hydroxylase; cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 fa; cytochrome p450 hlp2; cytochrome p450-pcn3

Target, Subunit, Species

Cytochrome P450 3A5

Target Mutant/Chimera Details

Cytochrome P450 3A5:Wild

Bioassay Category

Metabolism/Transport

Bioassay Details

Maximal velocity of the compound for 3-Hydroxylation reaction mediated by Cytochrome P450 3A5 from Baculovirus-infected insect cells

Substance RN

702691View in Reaxys

Qualitative Results

Vmax not calculated

Measurement Parameter

Qualitative

Measurement Object

Vmax

Target Name

Cytochrome P450 3A5

Target Synonyms

6-beta-testosterone hydroxylase; cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 fa; cytochrome p450 hlp2; cytochrome p450-pcn3

Target, Subunit, Species

Cytochrome P450 3A5

Target Mutant/Chimera Details

Cytochrome P450 3A5:Wild

Bioassay Category

Metabolism/Transport

Bioassay Details

Ratio of Michaelis-Menten constant of the compound for N-Demethylation reaction mediated by Cytochrome P450 3A5 to that of Cytochrome P450 3A4 from Baculovirus-infected insect cells

Substance RN

702691View in Reaxys

Measurement Parameter

Ratio

Quantitative value

0.57

Target Name

Cytochrome P450 3A4

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target, Subunit, Species

Cytochrome P450 3A4

Target Mutant/Chimera Details

Cytochrome P450 3A4:Wild

Bioassay Category

Metabolism/Transport

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Bioassay Details

779 of 976

780 of 976

781 of 976

Maximal velocity of the compound for 3-Hydroxylation reaction mediated by Cytochrome P450 3A4 from Baculovirus-infected insect cells

Substance RN

702691View in Reaxys

Qualitative Results

Vmax not calculated

Measurement Parameter

Qualitative

Measurement Object

Vmax

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Synonyms

bzrap1; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimsbinding protein 1; tspo-associated protein 1; tspoap1

Target Uniprot ID

q9jir0

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity of the compound towards rat cerebellum benzodiazepine receptor was determined

Biological Species/NCBI ID

Rattus norvegicus

Cells/Cell Lines

cerebellum cell

Substance RN

702691View in Reaxys

Measurement Parameter

Ki

Unit

nM

Qualitative value

=

Quantitative value

1.5

Measurement pX

8.82

Target Name

Cytochrome P450 3A5

Target Synonyms

6-beta-testosterone hydroxylase; cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 fa; cytochrome p450 hlp2; cytochrome p450-pcn3

Target, Subunit, Species

Cytochrome P450 3A5

Target Mutant/Chimera Details

Cytochrome P450 3A5:Wild

Bioassay Category

Metabolism/Transport

Bioassay Details

Ratio of Michaelis-Menten constant of the compound for 3-Hydroxylation reaction mediated by Cytochrome P450 3A5 to that of Cytochrome P450 3A4 from Baculovirus-infected insect cells

Substance RN

702691View in Reaxys

Measurement Parameter

Ratio

Quantitative value

0.49

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Synonyms

bzrap1; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimsbinding protein 1; tspo-associated protein 1; tspoap1

Target Uniprot ID

q9jir0

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]:Wild

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782 of 976

783 of 976

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Agonist

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Agonistic activity of the compound against benzodiazepine receptor was determined in rat cerebellar membrane

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Measurement Parameter

ED50

Unit

nM

Qualitative value

=

Quantitative value

0.007

Measurement pX

11.2

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Synonyms

bzrap1; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimsbinding protein 1; tspo-associated protein 1; tspoap1

Target Uniprot ID

q9jir0

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity of the compound towards benzodiazepine receptor in rat cerebellar membrane at 0 degree C was determined

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Measurement Parameter

Ki

Unit

nM

Qualitative value

=

Quantitative value

1.49

Deviation

0.09

Measurement pX

8.83

Bioassay Category

Pharmacokinetic

Bioassay Details

Cerebrospinal fluid to plasma concentration ratio of the compound in cat after intravenous dosage

Biological Species/NCBI ID

domestic cat

Substance RN

702691View in Reaxys

Substance Route of Adm.

intravenous administration

Measurement Parameter

CSF/Plasma ratio

Quantitative value

0.34

Lin, Jiunn H.; Current Drug Metabolism; vol. 9; nb. 1; (2008); p. 46 - 59, View in Reaxys

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784 of 976

Bioassay Category

Pharmacokinetic

Bioassay Details

Time taken to reach maximum plasma concentration in cat after intravenous dosage

Biological Species/NCBI ID

domestic cat

Substance RN

702691View in Reaxys

Substance Route of Adm.

intravenous administration

Measurement Parameter

Tmax

Unit

minute

Qualitative value

=

Quantitative value

8.3

Lin, Jiunn H.; Current Drug Metabolism; vol. 9; nb. 1; (2008); p. 46 - 59, View in Reaxys 785 of 976

786 of 976

787 of 976

Target Name

Cytochrome P450 3A5

Target Synonyms

6-beta-testosterone hydroxylase; cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 fa; cytochrome p450 hlp2; cytochrome p450-pcn3

Target, Subunit, Species

Cytochrome P450 3A5

Target Mutant/Chimera Details

Cytochrome P450 3A5:Wild

Bioassay Category

Metabolism/Transport

Bioassay Details

Ratio of intrinsic clearance of the compound for 3-Hydroxylation reaction mediated by Cytochrome P450 3A5 to that of Cytochrome P450 3A4 from Baculovirus-infected insect cells

Substance RN

702691View in Reaxys

Measurement Parameter

Ratio

Quantitative value

2.4

Target Name

Cytochrome P450 3A4

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target, Subunit, Species

Cytochrome P450 3A4

Target Mutant/Chimera Details

Cytochrome P450 3A4:Wild

Bioassay Category

Metabolism/Transport

Bioassay Details

Michaelis-Menten constant of the compound for 3-Hydroxylation mediated by Cytochrome P450 3A4 from Baculovirus-infected insect cells

Substance RN

702691View in Reaxys

Measurement Parameter

Km

Unit

µM

Qualitative value

=

Quantitative value

694

Measurement pX

3.16

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Synonyms

bzrap1; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimsbinding protein 1; tspo-associated protein 1; tspoap1

Target Uniprot ID

q9jir0

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]:Wild

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788 of 976

789 of 976

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity of the compound against Benzodiazepine receptor in rat cerebellar membrane at 0 degree C was determined

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Measurement Parameter

Ki

Unit

nM

Qualitative value

=

Quantitative value

1.49

Measurement pX

8.83

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1

Target Synonyms

bzrap1; kiaa0612; pbr-ip; peripheral benzodiazepine receptor-interacting protein; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimbp1; rims-binding protein 1; tspo-associated protein 1; tspoap1

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1:Wild

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity of the compound towards benzodiazepine receptor

Substance RN

702691View in Reaxys

Measurement Parameter

Qualitative

Qualitative value

Not Published

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

In vitro inhibitory concentration of the compound against growth of isolated Schistosoma mansoni BH from infected mouse portal vein or mesenteric vein upon incubation for 120 h at 37 degree C

Biological Species/NCBI ID

Schistosoma mansoni BH

Substance RN

702691View in Reaxys

Measurement Parameter

IC50

Unit

µM

Measurement Object

PARASITE GROWTH

Qualitative value

>

Quantitative value

50

Measurement pX

1

Menezes, Carla M.S.; Rivera, Gildardo; Alves, Marina A.; Do Amaral, Daniel N.; Thibaut, Jean Pierre B.; Noel, Francois; Barreiro, Eliezer J.; Lima, Lidia M.; Chemical Biology and Drug Design; vol. 79; nb. 6; (2012); p. 943 - 949, View in Reaxys 790 of 976

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1

Target Synonyms

bzrap1; kiaa0612; pbr-ip; peripheral benzodiazepine receptor-interacting protein; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimbp1; rims-binding protein 1; tspo-associated protein 1; tspoap1

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791 of 976

792 of 976

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1:Wild

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity of compound towards benzodiazepine receptor in a competition assay

Substance RN

702691View in Reaxys

Measurement Parameter

pIC50

Quantitative value

-0.58

Target Name

Gamma-aminobutyric acid receptor subunit delta;+Gamma-aminobutyric acid receptor subunit beta-2;+Gamma-aminobutyric acid receptor subunit alpha-1

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1; Gamma-aminobutyric acid receptor subunit beta-2; Gamma-aminobutyric acid receptor subunit delta

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta:Wild + Gamma-aminobutyric acid receptor subunit beta-2:Wild + Gamma-aminobutyric acid receptor subunit alpha-1:Wild

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity of compound against gamma-aminobutyric acid A-benzodiazepine receptor was determined using competition assay against diazepam

Substance RN

702691View in Reaxys

Measurement Parameter

pIC50

Quantitative value

-0.58

Target Name

Gamma-aminobutyric acid receptor subunit delta [human];+Gamma-aminobutyric acid receptor subunit beta-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

o14764 + p47870 + p14867

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]; Gamma-aminobutyric acid receptor subunit delta [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Percent modulation of human GABAA receptor alpha4beta3delta expressed in mouse L (TK) cells upon incubation with compound at a concentration of 3 uM in 10 mM HEPES, pH 7.3 using 5 mM Mg-ATP measured as maximum current amplitude

Biological Species/NCBI ID

human

Cells/Cell Lines

L-M(TK-) cell line

Substance RN

702691View in Reaxys

Measurement Parameter

%

Unit

%

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793 of 976

794 of 976

Measurement Object

Modulation

Qualitative value

=

Quantitative value

0.75

Deviation

2.8

Concomitants: Compound name

Mg-ATP

Concomitants: Compound role

COM

Target Name

Gamma-aminobutyric acid receptor subunit delta [human];+Gamma-aminobutyric acid receptor subunit beta-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

o14764 + p47870 + p14867

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]; Gamma-aminobutyric acid receptor subunit delta [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Percent modulation of human GABA A receptor alpha 4 beta 3 gamma 2 expressed in mouse L (TK) cells upon incubation with compound at a concentration of 3 uM in 10 mM HEPES, pH 7.3 using 5 mM Mg-ATP measured as maximum current amplitude

Biological Species/NCBI ID

human

Cells/Cell Lines

L-M(TK-) cell line

Substance RN

702691View in Reaxys

Measurement Parameter

%

Unit

%

Measurement Object

Modulation

Qualitative value

=

Quantitative value

-3.1

Deviation

5.7

Concomitants: Compound name

Mg-ATP

Concomitants: Compound role

COM

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lowest toxic dose of the compound in child upon p.o. administration

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Substance Route of Adm.

oral administration

Qualitative Results

3.478

Measurement Parameter

TDLo

Unit

mg/kg

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Measurement Object

Lowest toxic dose

Quantitative value

3.478

Roald; Dahl; Critical Care Medicine; vol. 17; nb. 12; (1989); p. 1355 - 1356, View in Reaxys 795 of 976

Bioassay Category

Pharmacokinetic

Bioassay Details

Percent excretion of unchanged compound in urine of human upon oral administration of 1.0 dose

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Substance Route of Adm.

oral administration

Measurement Parameter

Ue (%)

Unit

%

Measurement Object

AMOUNT OF UNCHANGED DRUG EXCRETED

Qualitative value

=

Quantitative value

0.5

Benet, Leslie Z.; Broccatelli, Fabio; Oprea, Tudor I.; AAPS Journal; vol. 13; nb. 4; (2011); p. 519 - 547, View in Reaxys 796 of 976

797 of 976

Target Name

Gamma-aminobutyric acid receptor subunit delta;+Gamma-aminobutyric acid receptor subunit beta-2;+Gamma-aminobutyric acid receptor subunit alpha-1

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1; Gamma-aminobutyric acid receptor subunit beta-2; Gamma-aminobutyric acid receptor subunit delta

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta:Wild + Gamma-aminobutyric acid receptor subunit beta-2:Wild + Gamma-aminobutyric acid receptor subunit alpha-1:Wild

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Affinity of the compound towards GABAA receptor alpha1beta3gamma2 was determined

Substance RN

702691View in Reaxys

Measurement Parameter

Activity

Unit

nM

Measurement Object

affinity

Qualitative value

=

Quantitative value

3

Bioassay Category

Metabolism/Transport

Bioassay Details

Distribution coefficient of the compound at PH 7.4 (LOG D7.4)

Substance RN

702691View in Reaxys

Measurement Parameter

Qualitative

Qualitative value

Not Published

Benet, Leslie Z.; Broccatelli, Fabio; Oprea, Tudor I.; AAPS Journal; vol. 13; nb. 4; (2011); p. 519 - 547, View in Reaxys 798 of 976

Target Name

Aldo-keto reductase family 1 member C1 [human]

Target Synonyms

20-alpha-hsd; 20-alpha-hydroxysteroid dehydrogenase; akr1c1; aldo-keto reductase family 1 member c1; chlordecone reductase homolog hakrc; dd1/dd2; ddh; ddh1; dihydrodiol dehydrogenase 1/2; hbab; high-affinity hepatic bile acid-binding protein; indanol dehydrogenase; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

Target Uniprot ID

q04828

Target PDB ID

1mrq; 3c3u; 3gug; 3nty; 4yvp

Target, Subunit, Species

Aldo-keto reductase family 1 member C1 [human]

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799 of 976

800 of 976

Target Mutant/Chimera Details

Aldo-keto reductase family 1 member C1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Inhibitory concentration of the compound against human AKR1C1 isoenzyme upon incubation in 0.1 M Potassium phosphate buffer, pH 7.4 at 25 degree C

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Measurement Parameter

IC50

Unit

µM

Qualitative value

=

Quantitative value

15

Measurement pX

4.82

Target Name

Aldo-keto reductase family 1 member C2 [human]

Target Synonyms

3-alpha-hsd3; akr1c2; aldo-keto reductase family 1 member c2; chlordecone reductase homolog hakrd; dd-2; dd/babp; dd2; ddh2; dihydrodiol dehydrogenase 2; dihydrodiol dehydrogenase/bile acid-binding protein; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type iii 3-alpha-hydroxysteroid dehydrogenase

Target Uniprot ID

p52895

Target PDB ID

1ihi; 1j96; 1xjb; 2hdj; 2ipj; 4jq1; 4jq2; 4jq3; 4jq4; 4jqa; 4jtq; 4jtr; 4l1w; 4l1x; 4xo6; 4xo7

Target, Subunit, Species

Aldo-keto reductase family 1 member C2 [human]

Target Mutant/Chimera Details

Aldo-keto reductase family 1 member C2 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Inhibitory concentration of the compound against human AKR1C2 isoenzyme upon incubation in 0.1 M Potassium phosphate buffer, pH 7.4 at 25 degree C

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Measurement Parameter

IC50

Unit

µM

Qualitative value

=

Quantitative value

13

Measurement pX

4.89

Target Name

Aldo-keto reductase family 1 member C4 [human]

Target Synonyms

3-alpha-hsd1; 3-alpha-hydroxysteroid dehydrogenase type i; akr1c4; aldo-keto reductase family 1 member c4; cdr; chdr; chlordecone reductase; dd-4; dd4; dihydrodiol dehydrogenase 4; hakra

Target Uniprot ID

p17516

Target PDB ID

2fvl

Target, Subunit, Species

Aldo-keto reductase family 1 member C4 [human]

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801 of 976

802 of 976

Target Mutant/Chimera Details

Aldo-keto reductase family 1 member C4 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Inhibitory concentration of the compound against human AKR1C4 isoenzyme upon incubation in 0.1 M Potassium phosphate buffer, pH 7.4 at 25 degree C

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Measurement Parameter

IC50

Unit

µM

Qualitative value

=

Quantitative value

32

Measurement pX

4.49

Target Name

Aldo-keto reductase family 1 member C3 [human]

Target Synonyms

17-beta-hsd 5; 17-beta-hydroxysteroid dehydrogenase type 5; 3-alpha-hsd type 2; 3-alpha-hsd type ii, brain; 3-alpha-hydroxysteroid dehydrogenase type 2; akr1c3; aldo-keto reductase family 1 member c3; chlordecone reductase homolog hakrb; dd-3; dd3; ddh1; dihydrodiol dehydrogenase 3; dihydrodiol dehydrogenase type i; ha1753; hsd17b5; indanol dehydrogenase; kiaa0119; pgfs; prostaglandin f synthase; testosterone 17-beta-dehydrogenase 5; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

Target Uniprot ID

p42330

Target PDB ID

1ry0; 1ry8; 1s1p; 1s1r; 1s2a; 1s2c; 1xf0; 1zq5; 2f38; 2fgb; 3r43; 3r58; 3r6i; 3r7m; 3r8g; 3r8h; 3r94; 3ufy; 3ug8; 3ugr; 3uwe; 4dbs; 4dbu; 4dbw; 4dz5; 4fa3; 4fal; 4fam; 4h7c; 4hmn; 4wdt; 4wdu; 4wdw; 4wdx; 4wrh; 4xvd; 4xve; 4yvv; 4yvx; 4zfc; 5hnt; 5hnu; 5jm5

Target, Subunit, Species

Aldo-keto reductase family 1 member C3 [human]

Target Mutant/Chimera Details

Aldo-keto reductase family 1 member C3 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Inhibitory concentration of the compound against human AKR1C3 isoenzyme upon incubation in 0.1 M Potassium phosphate buffer, pH 7.4 at 25 degree C

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Measurement Parameter

IC50

Unit

µM

Qualitative value

=

Quantitative value

58

Measurement pX

4.24

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1

Target Synonyms

bzrap1; kiaa0612; pbr-ip; peripheral benzodiazepine receptor-interacting protein; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimbp1; rims-binding protein 1; tspo-associated protein 1; tspoap1

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803 of 976

804 of 976

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1:Wild

Substance Action on Target

Agonist

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Agonist effect of the compound against anxiolytic response of Benzodiazepine receptor

Substance RN

702691View in Reaxys

Measurement Parameter

MED

Unit

µM/kg

Qualitative value

=

Quantitative value

1.5

Target Name

Gamma-aminobutyric acid receptor subunit delta [human];+Gamma-aminobutyric acid receptor subunit beta-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

o14764 + p47870 + p14867

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]; Gamma-aminobutyric acid receptor subunit delta [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Inhibition of [3H]Ro 15-1788 binding in membranes from cells expressing human GABAA receptor alpha(1-5)beta3gamma2; 2.1-4.5 nM

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Measurement Parameter

Ki

Unit

nM

Qualitative value

=

Quantitative value

4.5

Measurement pX

8.35

Concomitants: Compound name

[3H]Ro 15-1788

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit delta;+Gamma-aminobutyric acid receptor subunit beta-2;+Gamma-aminobutyric acid receptor subunit alpha-1

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1; Gamma-aminobutyric acid receptor subunit beta-2; Gamma-aminobutyric acid receptor subunit delta

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta:Wild + Gamma-aminobutyric acid receptor subunit beta-2:Wild + Gamma-aminobutyric acid receptor subunit alpha-1:Wild

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805 of 976

806 of 976

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Inhibition of [3H]Ro 15-4513 binding in membranes from cells expressing gamma-aminobutyricacid A receptor alpha6beta3gamma2

Substance RN

702691View in Reaxys

Measurement Parameter

Ki

Unit

nM

Qualitative value

>

Quantitative value

2000

Measurement pX

5.7

Concomitants: Compound name

[3H]Ro 15-4513

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit delta;+Gamma-aminobutyric acid receptor subunit beta-2;+Gamma-aminobutyric acid receptor subunit alpha-1

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1; Gamma-aminobutyric acid receptor subunit beta-2; Gamma-aminobutyric acid receptor subunit delta

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta:Wild + Gamma-aminobutyric acid receptor subunit beta-2:Wild + Gamma-aminobutyric acid receptor subunit alpha-1:Wild

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Inhibition of [3H]Ro 15-1788 binding in cells expressing gamma-aminobutyric-acid A receptor alpha(1-5)beta3gamma2; range is 2.1-4.5 nM

Substance RN

702691View in Reaxys

Measurement Parameter

Ki

Unit

nM

Qualitative value

=

Quantitative value

4.5

Measurement pX

8.35

Concomitants: Compound name

[3H]Ro 15-1788

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit delta [human];+Gamma-aminobutyric acid receptor subunit beta-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

o14764 + p47870 + p14867

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]; Gamma-aminobutyric acid receptor subunit delta [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

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807 of 976

Target Species (Bioactivity)

human

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Inhibition of [3H]Ro 15-4513 in membranes from cells expressing alpha6beta3gamma2 receptor subtype

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Measurement Parameter

Ki

Unit

µM

Qualitative value

>

Quantitative value

2

Measurement pX

5.7

Bioassay Category

Pharmacokinetic

Bioassay Details

Percent of compound reaching the systemic circulation after oral administration in humans

Substance RN

702691View in Reaxys

Substance Route of Adm.

oral administration

Measurement Parameter

F(%)

Unit

%

Qualitative value

>

Quantitative value

80

Yoshida, Fumitaka; Topliss, John G.; Journal of Medicinal Chemistry; vol. 43; nb. 13; (2000); p. 2575 - 2585, View in Reaxys 808 of 976

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Oral lethal dose in rat

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Route of Adm.

oral administration

Qualitative Results

2.76

Measurement Parameter

LD50

Unit

mg/kg

Quantitative value

2.76

Kiso to Rinsho Clinical Report, 1985, 19, 1277; vol. 19; (1985); p. 1277, View in Reaxys 809 of 976

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lowest toxic dose of the compound in infant upon p.o. administration causing dyspnea

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Substance Route of Adm.

oral administration

Qualitative Results

0.222

Measurement Parameter

TDLo

Unit

mg/kg

Measurement Object

Lowest toxic dose

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Quantitative value

0.222

Gekkan Yakuji. Pharmaceuticals Monthly.,1996, 38, 2597.; vol. 38; (1996); p. 2597, View in Reaxys 810 of 976

811 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Details

Maximum velocity for CYP3A4 catalyzed 3-hydroxyflunitrazepam formation in human liver microsomes

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Qualitative Results

19.3

Measurement Parameter

Qualitative

Measurement Object

Vmax

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Synonyms

bzrap1; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimsbinding protein 1; tspo-associated protein 1; tspoap1

Target Uniprot ID

q9jir0

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

In vitro inhibitory concentration of the compound to displace ~1 nM [3H]flunitrazepam from benzodiazepine receptor in rat upon incubation at 0-4 degree C for 60 min

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Measurement Parameter

IC50

Unit

nM

Qualitative value

=

Quantitative value

3.8

Measurement pX

8.42

Concomitants: Compound name

[3H]Flunitrazepam

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Concomitants: Compound role 812 of 976

813 of 976

814 of 976

RAD

Target Name

Cytochrome P450 3A5 [human]

Target Synonyms

cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 hlp2; cytochrome p450-pcn3

Target Uniprot ID

p20815

Target, Subunit, Species

Cytochrome P450 3A5 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A5 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Details

Maximum velocity for CYP3A5 catalyzed 3-hydroxyflunitrazepam formation in human liver microsomes

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Qualitative Results

3.85

Measurement Parameter

Qualitative

Measurement Object

Vmax

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Details

Maximum velocity for CYP3A4 catalyzed N-desmethylflunitrazepam formation in human liver microsomes

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Qualitative Results

0.550

Measurement Parameter

Qualitative

Measurement Object

Vmax

Target Name

Cytochrome P450 3A5 [human]

Target Synonyms

cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 hlp2; cytochrome p450-pcn3

Target Uniprot ID

p20815

Target, Subunit, Species

Cytochrome P450 3A5 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A5 [human]:Wild

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815 of 976

816 of 976

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Details

Michaelis-Menton constant for for CYP3A5 catalyzed N-desmethylflunitrazepam formation in human liver microsomes

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Qualitative Results

43.8

Measurement Parameter

Km

Unit

µM

Measurement Object

Michaelis Menten constant

Quantitative value

43.8

Measurement pX

4.36

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Details

Michaelis-Menton constant for for CYP3A4 catalyzed N-desmethylflunitrazepam formation in human liver microsomes

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Qualitative Results

35.6

Measurement Parameter

Km

Unit

µM

Measurement Object

Michaelis Menten constant

Quantitative value

35.6

Measurement pX

4.45

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

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817 of 976

818 of 976

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Details

Michaelis-Menton constant for CYP3A4 catalyzed 3-hydroxyflunitrazepam formation in human liver microsomes

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Qualitative Results

106

Measurement Parameter

Km

Unit

µM

Measurement Object

Michaelis Menten constant

Quantitative value

106

Measurement pX

3.97

Target Name

Cytochrome P450 3A5 [human]

Target Synonyms

cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 hlp2; cytochrome p450-pcn3

Target Uniprot ID

p20815

Target, Subunit, Species

Cytochrome P450 3A5 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A5 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Details

Michaelis-Menton constant for CYP3A5 catalyzed 3-hydroxyflunitrazepam formation in human liver microsomes

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Qualitative Results

49.3

Measurement Parameter

Km

Unit

µM

Measurement Object

Michaelis Menten constant

Quantitative value

49.3

Measurement pX

4.31

Target Name

Cytochrome P450 3A5 [human]

Target Synonyms

cyp3a5; cypiiia5; cytochrome p450 3a5; cytochrome p450 hlp2; cytochrome p450-pcn3

Target Uniprot ID

p20815

Target, Subunit, Species

Cytochrome P450 3A5 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A5 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Details

Maximum velocity for CYP3A5 catalyzed N-desmethylflunitrazepam formation in human liver microsomes

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Biological Species/NCBI ID

819 of 976

human

Substance RN

702691View in Reaxys

Qualitative Results

0.217

Measurement Parameter

Qualitative

Measurement Object

Vmax

Bioassay Category

In Vivo (Animal models)

Bioassay Details

Anticonvulsant activity expressed as the dose which prevented convulsions in 50 of the mice tested after subcutaneous administration of 125 mg/kg was measured by metrazole test

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Substance Route of Adm.

subcutaneous administration

Measurement Parameter

ED50

Unit

mg/kg

Qualitative value

=

Quantitative value

2.41

Blair; Webb; Journal of Medicinal Chemistry; vol. 20; nb. 9; (1977); p. 1206 - 1210, View in Reaxys 820 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Sedation and muscle relaxation effect expressed as dose required to produce relaxation of the body and hind legs when the cats were suspended by the scruff of the neck

Biological Species/NCBI ID

domestic cat

Substance RN

702691View in Reaxys

Measurement Parameter

MED

Unit

mg/kg

Measurement Object

Sedation and muscle relaxation effect

Qualitative value

=

Quantitative value

4.19

Blair; Webb; Journal of Medicinal Chemistry; vol. 20; nb. 9; (1977); p. 1206 - 1210, View in Reaxys 821 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Sedative and muscle relaxant effect expressed as dose which caused three out of six mice to slide off a 70 degree inclined screen

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Measurement Parameter

ED50

Unit

mg/kg

Measurement Object

Sedative and muscle relaxant effect

Qualitative value

=

Quantitative value

2.49

Blair; Webb; Journal of Medicinal Chemistry; vol. 20; nb. 9; (1977); p. 1206 - 1210, View in Reaxys 822 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Taming activity expressed as dose required to tame pairs of fighting mice, their aggression being stimulated by an electrical current applied to their feet using footshock or fighting mice test

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Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Measurement Parameter

MED

Unit

mg/kg

Qualitative value

=

Quantitative value

2.59

Blair; Webb; Journal of Medicinal Chemistry; vol. 20; nb. 9; (1977); p. 1206 - 1210, View in Reaxys 823 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Taming activity expressed as dose required to tame pairs of fighting mice their aggression being stimulated by an electrical current applied to their feet using footshock or fighting mice test

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Measurement Parameter

MED

Unit

mg/kg

Qualitative value

=

Quantitative value

2.59

Blair; Webb; Journal of Medicinal Chemistry; vol. 20; nb. 9; (1977); p. 1206 - 1210, View in Reaxys 824 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

Partition Coefficient of the compound was determined

Substance RN

702691View in Reaxys

Measurement Parameter

Qualitative

Measurement Object

Partition coefficient

Qualitative value

Not Published

Alelyunas, Yun W.; Empfield, James R.; McCarthy, Dennis; Spreen, Russell C.; Bui, Khanh; Pelosi-Kilby, Luciana; Shen, Cindy; Bioorganic and Medicinal Chemistry Letters; vol. 20; nb. 24; (2010); p. 7312 - 7316, View in Reaxys 825 of 976

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lethal dose of the compound in rat upon intramuscular administration

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Qualitative Results

> 2000

Measurement Parameter

LD50

Unit

mg/kg

Quantitative value

2000

Kiso to Rinsho. Clinical Report.,1985, 19, 1277.; vol. 19; (1985); p. 1277, View in Reaxys 826 of 976

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lethal dose of the compound in rat upon intraperitoneal administration

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Qualitative Results

1060

Measurement Parameter

LD50

Unit

mg/kg

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Quantitative value

1060

Kiso to Rinsho. Clinical Report.,1985, 19, 1277.; vol. 19; (1985); p. 1277, View in Reaxys 827 of 976

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lethal dose of the compound in rat upon subcutaneous administration

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Qualitative Results

> 4000

Measurement Parameter

LD50

Unit

mg/kg

Quantitative value

4000

Kiso to Rinsho. Clinical Report.,1985, 19, 1277.; vol. 19; (1985); p. 1277, View in Reaxys 828 of 976

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lethal dose of the compound in mouse upon intramuscular administration

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Qualitative Results

> 2000

Measurement Parameter

LD50

Unit

mg/kg

Quantitative value

2000

Kiso to Rinsho. Clinical Report.,1985, 19, 1277.; vol. 19; (1985); p. 1277, View in Reaxys 829 of 976

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lethal dose of the compound in mouse upon p.o. administration

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Substance Route of Adm.

oral administration

Qualitative Results

1200

Measurement Parameter

LD50

Unit

mg/kg

Measurement Object

Lethal dose

Quantitative value

1200

Kiso to Rinsho. Clinical Report.,1985, 19, 1277.; vol. 19; (1985); p. 1277, View in Reaxys 830 of 976

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lethal dose of the compound in mouse upon intraperitoneal administration

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Substance Route of Adm.

intraperitoneal administration

Qualitative Results

1050

Measurement Parameter

LD50

Unit

mg/kg

Quantitative value

1050

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Kiso to Rinsho. Clinical Report.,1985, 19, 1277.; vol. 19; (1985); p. 1277, View in Reaxys 831 of 976

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lethal dose of the compound in rat upon p.o. administration

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Route of Adm.

oral administration

Qualitative Results

415

Measurement Parameter

LD50

Unit

mg/kg

Measurement Object

Lethal dose

Quantitative value

415

Kiso to Rinsho. Clinical Report.,1985, 19, 1277.; vol. 19; (1985); p. 1277, View in Reaxys 832 of 976

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lethal dose of the compound in mouse upon subcutaneous administration

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Qualitative Results

> 4000

Measurement Parameter

LD50

Unit

mg/kg

Quantitative value

4000

Kiso to Rinsho. Clinical Report.,1985, 19, 1277.; vol. 19; (1985); p. 1277, View in Reaxys 833 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

Plasma half life (elimination)

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Qualitative Results

16-35

Measurement Parameter

t1/2 el

Unit

hour

Quantitative value

25.5

Clarke's Analysis of Drugs and Poisons, View in Reaxys 834 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

Plasma binding of the compound

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Qualitative Results

77-80

Measurement Parameter

Protein binding (%)

Unit

%

Measurement Object

Plasma binding

Quantitative value

78.5

Clarke's Analysis of Drugs and Poisons, View in Reaxys

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

440/493

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835 of 976

Bioassay Category

Pharmacokinetic

Bioassay Details

Mean peak plasma concentration after a oral dose daily for 28 days

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Qualitative Results

0.0015

Measurement Parameter

Concentration

Unit

µg/mL

Quantitative value

0.0015

Clarke's Analysis of Drugs and Poisons, View in Reaxys 836 of 976

Bioassay Category

Pharmacokinetic

Bioassay Details

Mean peak plasma concentration after a single oral dose

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Qualitative Results

0.0020

Measurement Parameter

Concentration

Unit

µg/mL

Quantitative value

0.002

Clarke's Analysis of Drugs and Poisons, View in Reaxys 837 of 976

Bioassay Category

Pharmacokinetic

Bioassay Details

Mean peak plasma concentration after a single oral dose

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Qualitative Results

0.0025

Measurement Parameter

Concentration

Unit

µg/mL

Quantitative value

0.0025

Clarke's Analysis of Drugs and Poisons, View in Reaxys 838 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

Plasma half life (distribution)

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Qualitative Results

3

Measurement Parameter

t1/2 el

Unit

hour

Quantitative value

3

Clarke's Analysis of Drugs and Poisons, View in Reaxys 839 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

Bioavailability of the compound

Biological Species/NCBI ID

human

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

441/493

2018-04-14 18:48:42


Substance RN

702691View in Reaxys

Qualitative Results

80 - 90

Measurement Parameter

F(%)

Measurement Object

Bioavailability

Qualitative value

@

Clarke's Analysis of Drugs and Poisons, View in Reaxys 840 of 976

Bioassay Category

Pharmacokinetic

Bioassay Details

Time to peak plasma concentration after a single oral dose

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Substance Route of Adm.

oral administration

Qualitative Results

1

Measurement Parameter

Tmax

Unit

hour

Quantitative value

1

Clarke's Analysis of Drugs and Poisons, View in Reaxys 841 of 976

Bioassay Category

Pharmacokinetic

Bioassay Details

Clearance of the compound

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Substance Route of Adm.

oral administration

Qualitative Results

2

Measurement Parameter

Cl

Unit

mL/min/kg

Quantitative value

2

Clarke's Analysis of Drugs and Poisons, View in Reaxys 842 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

Volume of distribution of the compound

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Qualitative Results

3.5 - 5.5

Measurement Parameter

Vd

Unit

L/kg

Measurement Object

Volume of distribution

Quantitative value

4.5

Clarke's Analysis of Drugs and Poisons, View in Reaxys 843 of 976

Bioassay Category

Pharmacokinetic

Bioassay Details

Fecal excretion of the compound in humans

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

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442/493

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Qualitative Results

10

Measurement Parameter

Ue (%)

Unit

%

Measurement Object

Excretion

Quantitative value

10

Clarke's Analysis of Drugs and Poisons, View in Reaxys 844 of 976

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Oral lethal dose in rat

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Substance Route of Adm.

oral administration

Measurement Parameter

LD50

Unit

mg/kg

Qualitative value

=

Quantitative value

415

Kiso to Rinsho, 1985, 19, 1277; vol. 19; (1985); p. 1277, View in Reaxys 845 of 976

Target Name

Platelet-activating factor receptor

Target Synonyms

paf receptor; paf-r; pafr; platelet activating factor receptor; platelet activating factor receptor activity; platelet-activating factor receptor; ptafr

Target, Subunit, Species

Platelet-activating factor receptor

Target Mutant/Chimera Details

Platelet-activating factor receptor:Wild

Substance Action on Target

Antagonist

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Antagonistic activity towards platelet activating factor receptor

Substance RN

702691View in Reaxys

Measurement Parameter

Qualitative

Qualitative value

Not Published

Patent; Casals-Stenzel, Jorge, Dr.; Weber, Karl-Heinz, Dr.; Walther, Gerhard, Dr.; Harreus, Albrecht, Dr; Muacevic, Gojki, Dr.; EP176928; (A2); (1986), View in Reaxys 846 of 976

Substance Action on Target

Inhibitor

Bioassay Category

In Vivo (Animal models)

Bioassay Details

Inhibitory concentration against PAF-induced bronchoconstriction in guinea pig upon treatment at 1 to ~50 mg/kg (p.o.) or 0.1 - 1.0 mg/kg (i.v.) after 1 hour of intravenous infusion with PAF

Biological Species/NCBI ID

guinea pig

Substance RN

702691View in Reaxys

Measurement Parameter

IC50

Unit

µM

Measurement Object

Inhibition of PAF-induced bronchoconstriction in guinea pig

Qualitative value

=

Quantitative value

46

Measurement pX

4.34

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

443/493

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Patent; Casals-Stenzel, Jorge, Dr.; Weber, Karl-Heinz, Dr.; Walther, Gerhard, Dr.; Harreus, Albrecht, Dr; Muacevic, Gojki, Dr.; EP176928; (A2); (1986), View in Reaxys 847 of 976

848 of 976

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1

Target Synonyms

bzrap1; kiaa0612; pbr-ip; peripheral benzodiazepine receptor-interacting protein; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimbp1; rims-binding protein 1; tspo-associated protein 1; tspoap1

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1:Wild

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Activity of the compound against Benzodiazepine receptor

Substance RN

702691View in Reaxys

Measurement Parameter

Qualitative

Qualitative value

Not Published

Bioassay Category

Metabolism/Transport

Bioassay Details

In vivo clearance of the compound in human liver microsomes was determined

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Measurement Parameter

Cl

Unit

mL/min/kg

Measurement Object

Clearance

Qualitative value

=

Quantitative value

7.18

Lee, Soyoung; Kim, Dongsup; Archives of Pharmacal Research; vol. 30; nb. 2; (2007); p. 182 - 190, View in Reaxys 849 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

In vivo clearance of the compound in rat liver microsomes was determined

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Measurement Parameter

Cl

Unit

mL/min/kg

Measurement Object

Clearance

Qualitative value

=

Quantitative value

79.17

Lee, Soyoung; Kim, Dongsup; Archives of Pharmacal Research; vol. 30; nb. 2; (2007); p. 182 - 190, View in Reaxys 850 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

In vitro clearance of the compound in rat liver microsomes was determined

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Measurement Parameter

Cl

Unit

mL/min/kg

Measurement Object

Clearance

Qualitative value

=

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2018-04-14 18:48:42


Quantitative value

70.59

Lee, Soyoung; Kim, Dongsup; Archives of Pharmacal Research; vol. 30; nb. 2; (2007); p. 182 - 190, View in Reaxys 851 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

In vitro clearance of the compound in human liver microsomes was determined

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Measurement Parameter

Cl

Unit

mL/min/kg

Measurement Object

Clearance

Qualitative value

=

Quantitative value

4.03

Lee, Soyoung; Kim, Dongsup; Archives of Pharmacal Research; vol. 30; nb. 2; (2007); p. 182 - 190, View in Reaxys 852 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

In vivo unbound intrinsic clearance of compound in human hepatocytes

Biological Species/NCBI ID

human

Cells/Cell Lines

liver cell

Substance RN

702691View in Reaxys

Measurement Parameter

Clint

Unit

mL/min/kg

Qualitative value

=

Quantitative value

12.7

Hallifax, David; Turlizzi, Elisa; Zanelli, Ugo; Houston, J. Brian; European Journal of Pharmaceutical Sciences; vol. 45; nb. 5; (2012); p. 570 - 574, View in Reaxys 853 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

Permeability of the compound was calculated

Substance RN

702691View in Reaxys

Measurement Parameter

Papp (transport)

Unit

cm/s

Qualitative value

=

Quantitative value

8.55E-06

Hallifax, David; Turlizzi, Elisa; Zanelli, Ugo; Houston, J. Brian; European Journal of Pharmaceutical Sciences; vol. 45; nb. 5; (2012); p. 570 - 574, View in Reaxys 854 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

In vitro unbound intrinsic clearance of compound in human hepatocytes

Biological Species/NCBI ID

human

Cells/Cell Lines

liver cell

Substance RN

702691View in Reaxys

Measurement Parameter

Clint

Unit

mL/min/kg

Qualitative value

=

Quantitative value

4.5

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

445/493

2018-04-14 18:48:42


Hallifax, David; Turlizzi, Elisa; Zanelli, Ugo; Houston, J. Brian; European Journal of Pharmaceutical Sciences; vol. 45; nb. 5; (2012); p. 570 - 574, View in Reaxys 855 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

Partition Coefficient of the compound was determined

Substance RN

702691View in Reaxys

Measurement Parameter

Qualitative

Measurement Object

Partition coefficient

Qualitative value

Not Published

Dimitra Hadjipavlou-Litina; Corwin Hansch; Chemical reviews; vol. 94; nb. 6; (1994); p. 1483 - 1505, View in Reaxys 856 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

Partition Coefficient of the compound was determined

Substance RN

702691View in Reaxys

Measurement Parameter

Qualitative

Measurement Object

Partition coefficient

Qualitative value

Not Published

Dimitra Hadjipavlou-Litina; Corwin Hansch; Chemical reviews; vol. 94; nb. 6; (1994); p. 1483 - 1505, View in Reaxys 857 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Anticonvulsant activity of compound was evaluated using anti-pentylenetetrazole test

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Measurement Parameter

pIC50

Quantitative value

2.42

Measurement pX

2.42

Dimitra Hadjipavlou-Litina; Corwin Hansch; Chemical reviews; vol. 94; nb. 6; (1994); p. 1483 - 1505, View in Reaxys 858 of 976

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1 [taurine cattle]

Target Synonyms

peripheral-type benzodiazepine receptor-associated protein 1

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1 [taurine cattle]

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1 [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Inhibition of specific [3H]RO15-1788 binding to benzodiazepine receptor from bovine brain membranes at 10 uM concentration

Biological Species/NCBI ID

taurine cattle

Substance RN

702691View in Reaxys

Measurement Parameter

pKi

Quantitative value

8.664

Measurement pX

8.66

Concomitants: Compound name

[3H]Ro 15-1788

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859 of 976

Concomitants: Compound role

RAD

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Anticonvulsant activity of compound was evaluated using anti-pentylenetetrazole test mouse

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Measurement Parameter

pIC50

Quantitative value

2.42

Measurement pX

2.42

Dimitra Hadjipavlou-Litina; Corwin Hansch; Chemical reviews; vol. 94; nb. 6; (1994); p. 1483 - 1505, View in Reaxys 860 of 976

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Synonyms

bzrap1; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimsbinding protein 1; tspo-associated protein 1; tspoap1

Target Uniprot ID

q9jir0

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Inhibition of the binding of [3H]diazepam to Benzodiazepine receptor in homogenates of rat brain cell membranes

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Measurement Parameter

pIC50

Quantitative value

8.42

Measurement pX

8.42

Concomitants: Compound name

[3H]Diazepam

Concomitants: Compound role

RAD

Dimitra Hadjipavlou-Litina; Corwin Hansch; Chemical reviews; vol. 94; nb. 6; (1994); p. 1483 - 1505, View in Reaxys 861 of 976

Target Name

chloride channel

Target Synonyms

chloride channel; chloride channel activity

Target, Subunit, Species

chloride channel

Target Mutant/Chimera Details

chloride channel:Wild

Substance Action on Target

Agonist

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Agonistic activity of compound towards chloride channel receptor

Substance RN

702691View in Reaxys

Measurement Parameter

Qualitative

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862 of 976

Qualitative value

Not Published

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Synonyms

bzrap1; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimsbinding protein 1; tspo-associated protein 1; tspoap1

Target Uniprot ID

q9jir0

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Compound was tested for 50 inhibition of the binding of [3H]diazepam to Benzodiazepine receptor in homogenates of rat brain cell membranes

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Measurement Parameter

pIC50

Quantitative value

8.42

Measurement pX

8.42

Concomitants: Compound name

[3H]Diazepam

Concomitants: Compound role

RAD

Dimitra Hadjipavlou-Litina; Corwin Hansch; Chemical reviews; vol. 94; nb. 6; (1994); p. 1483 - 1505, View in Reaxys 863 of 976

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lowest toxic dose of the compound in women upon p.o. administration

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Substance Route of Adm.

oral administration

Qualitative Results

0.127

Measurement Parameter

TDLo

Unit

mg/kg

Measurement Object

Lowest toxic dose

Quantitative value

0.127

Hofer; Scollo-Lavizzari; Archives of Internal Medicine; vol. 145; nb. 4; (1985); p. 663 - 664, View in Reaxys 864 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

Bound in plasma; 77-79

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Qualitative Results

77-79

Measurement Parameter

Protein binding (%)

Unit

%

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448/493

2018-04-14 18:48:42


Quantitative value

78

Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th ed., 1996; (1996), View in Reaxys 865 of 976

Bioassay Category

Pharmacokinetic

Bioassay Details

Time to peak plasma concentration in human administered 1 mg orally

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Substance Route of Adm.

oral administration

Qualitative Results

1.2 +/- 0.8

Measurement Parameter

Tmax

Unit

hour

Quantitative value

1.2

Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th ed., 1996; (1996), View in Reaxys 866 of 976

Bioassay Category

Pharmacokinetic

Bioassay Details

Volume of distribution

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Substance Route of Adm.

intravenous administration

Qualitative Results

3.3 +/- 0.6

Measurement Parameter

Vd

Unit

L/kg

Quantitative value

3.3

Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th ed., 1996; (1996), View in Reaxys 867 of 976

Bioassay Category

Pharmacokinetic

Bioassay Details

Oral bioavailability

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Substance Route of Adm.

oral administration

Qualitative Results

~85

Measurement Parameter

F(%)

Unit

%

Quantitative value

85

Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th ed., 1996; (1996), View in Reaxys 868 of 976

Bioassay Category

Pharmacokinetic

Bioassay Details

Urinary Excretion

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Qualitative Results

<1

Measurement Parameter

Qualitative

Measurement Object

Urinary excretion

Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th ed., 1996; (1996), View in Reaxys

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869 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

Half life in human

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Qualitative Results

15 +/- 5

Measurement Parameter

t1/2 el

Unit

hour

Measurement Object

Half Life

Quantitative value

15

Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th ed., 1996; (1996), View in Reaxys 870 of 976

Bioassay Category

Pharmacokinetic

Bioassay Details

Clearance of the compound

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Substance Route of Adm.

oral administration

Qualitative Results

3.5 +/- 0.4

Measurement Parameter

Cl

Unit

mL/min/kg

Quantitative value

3.5

Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th ed., 1996; (1996), View in Reaxys 871 of 976

872 of 976

Target Name

Cytochrome P450 2C9 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cholesterol 25-hydroxylase; cyp2c10; cyp2c9; cypiic9; cytochrome p-450mp; cytochrome p450 2c9; cytochrome p450 mp-4; cytochrome p450 mp-8; cytochrome p450 pb-1; s-mephenytoin 4-hydroxylase

Target Uniprot ID

p11712

Target PDB ID

1og2; 1og5; 1r9o; 4nz2; 5a5i; 5a5j

Target, Subunit, Species

Cytochrome P450 2C9 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C9 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

Metabolism/Transport

Bioassay Details

Percent relative contribution of human CYTOCHROME P450 2C9 to the overall clearance of compound

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Qualitative Results

Range = 10 % to 15 %

Measurement Parameter

%

Unit

%

Measurement Object

RELATIVE CONTRIBUTION TO OVERALL CLEARANCE

Quantitative value

10 - 15

Bioassay Category

In Vitro (Efficacy)

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450/493

2018-04-14 18:48:42


Bioassay Details

Logarithm of effective dose of the compound evaluated using the foot-shock test in mice

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Unit

mM/kg

Qualitative value

=

Quantitative value

2.59

Lukovits; Journal of Medicinal Chemistry; vol. 26; nb. 8; (1983); p. 1104 - 1109, View in Reaxys 873 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Logarithm of effective dose of the compound determined using foot-shock test in mice

Biological Species/NCBI ID

Mus musculus

Substance RN

702691View in Reaxys

Unit

mM/kg

Measurement Object

Logarithm of effective dose

Qualitative value

=

Quantitative value

2.59

Lukovits; Journal of Medicinal Chemistry; vol. 26; nb. 8; (1983); p. 1104 - 1109, View in Reaxys 874 of 976

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Synonyms

bzrap1; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimsbinding protein 1; tspo-associated protein 1; tspoap1

Target Uniprot ID

q9jir0

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

In vitro inhibitory activity of the compound (40 uM) against rat brain benzodiazepine receptor using [3H]diazepam (2.6 nM) as radioligand incubated for 90 min at 0 degree C in Tris-HCL cold buffer (50 nM)

Biological Species/NCBI ID

Rattus norvegicus

Cells/Cell Lines

brain cell

Substance RN

702691View in Reaxys

Substance Dose

= 40 µm

Measurement Parameter

IC50

Unit

µM

Qualitative value

=

Quantitative value

0.005

Deviation

0.0015

Measurement pX

8.3

Concomitants: Compound name

[3H]Diazepam

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Concomitants: Compound role 875 of 976

876 of 976

RAD

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Synonyms

bzrap1; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimsbinding protein 1; tspo-associated protein 1; tspoap1

Target Uniprot ID

q9jir0

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity against benzodiazepine receptor in rat brain membranes using [3H]diazepam as radioligand

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Measurement Parameter

IC50

Unit

nM

Qualitative value

=

Quantitative value

5

Measurement pX

8.3

Concomitants: Compound name

[3H]Diazepam

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit delta [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus];+Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18506 + p63138 + p62813

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]; Gamma-aminobutyric acid receptor subunit delta [Rattus norvegicus]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [Rattus norvegicus]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

GABA ratio was calculated between IC50 without GABA and IC50 with GABA

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Measurement Parameter

Ratio

Quantitative value

1.41

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877 of 976

878 of 976

879 of 976

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Synonyms

bzrap1; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimsbinding protein 1; tspo-associated protein 1; tspoap1

Target Uniprot ID

q9jir0

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Ratio of inhibitory concentration determined without GABA to that of with GABA

Biological Species/NCBI ID

Rattus norvegicus

Cells/Cell Lines

brain cell

Substance RN

702691View in Reaxys

Measurement Parameter

Ratio

Quantitative value

1.41

Target Name

Glucocorticoid receptor

Target Synonyms

glucocorticoid receptor; glucocorticoid receptor activity; gr; grl; grl1; nr3c1; nuclear receptor subfamily 3 group c member 1

Target, Subunit, Species

Glucocorticoid receptor

Target Mutant/Chimera Details

Glucocorticoid receptor:Wild

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity of compound towards Glucocorticoid receptor relative with dexamethasone (Formal charge = neutral)

Substance RN

702691View in Reaxys

Qualitative Results

RBA>1.0 indicates a more active

Measurement Parameter

Binding Score

Qualitative value

@

Bioassay Category

Metabolism/Transport

Bioassay Details

Clearance of the compound was determined

Substance RN

702691View in Reaxys

Measurement Parameter

Cl

Unit

mL/min/g

Measurement Object

Clearance

Qualitative value

=

Quantitative value

3.5

Quinones-Torrelo; Martin-Biosca; Martinez-Pla; Sagrado; Villanueva-Camanas; Medina-Hernandez; Mini reviews in medicinal chemistry; vol. 2; nb. 2; (2002); p. 145 - 161, View in Reaxys 880 of 976

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Synonyms

bzrap1; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimsbinding protein 1; tspo-associated protein 1; tspoap1

Target Uniprot ID

q9jir0

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881 of 976

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

In vitro ability of the compound to displace ~ 1 nM [3H]flunitrazepam from benzodiazepine receptor in rat

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Measurement Parameter

IC50

Unit

nM

Qualitative value

=

Quantitative value

3.8

Measurement pX

8.42

Concomitants: Compound name

[3H]Flunitrazepam

Concomitants: Compound role

RAD

Bioassay Category

Metabolism/Transport

Bioassay Details

Volume of distribution of the compound was determined

Substance RN

702691View in Reaxys

Measurement Parameter

Vd

Unit

L/kg

Measurement Object

Volume of distribution

Qualitative value

=

Quantitative value

3.3

Quinones-Torrelo; Martin-Biosca; Martinez-Pla; Sagrado; Villanueva-Camanas; Medina-Hernandez; Mini reviews in medicinal chemistry; vol. 2; nb. 2; (2002); p. 145 - 161, View in Reaxys 882 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

Renal elimination of the compound was determined

Substance RN

702691View in Reaxys

Measurement Parameter

%

Unit

%

Measurement Object

Renal elimination

Qualitative value

=

Quantitative value

0

Quinones-Torrelo; Martin-Biosca; Martinez-Pla; Sagrado; Villanueva-Camanas; Medina-Hernandez; Mini reviews in medicinal chemistry; vol. 2; nb. 2; (2002); p. 145 - 161, View in Reaxys 883 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

Blood-brain distribution measured by LFER model was determined and expressed as log BB (conc. in brain / conc. in blood)

Substance RN

702691View in Reaxys

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Measurement Parameter

Log BB

Measurement Object

Blood-brain distribution

Quantitative value

0.06

Platts, James A.; Abraham, Michael H.; Zhao, Yuan H.; Hersey, Anne; Ijaz, Luke; Butina, Darko; European Journal of Medicinal Chemistry; vol. 36; nb. 9; (2001); p. 719 - 730, View in Reaxys 884 of 976

Bioassay Category

Pharmacokinetic

Bioassay Details

Bioavailability of the compound was determined after oral administration

Substance RN

702691View in Reaxys

Substance Route of Adm.

oral administration

Measurement Parameter

F(%)

Unit

%

Measurement Object

Bioavailability

Qualitative value

=

Quantitative value

85

Fecik, Robert A.; Frank, Kristine E.; Gentry, Elmer J.; Menon, Sanjay R.; Mitscher, Lester A.; Telikepalli, Hanumaiah; Medicinal Research Reviews; vol. 18; nb. 3; (1998); p. 149 - 185, View in Reaxys 885 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

In vivo plasma clearance of compound in rat

Biological Species/NCBI ID

Rattus norvegicus

Cells/Cell Lines

plasma cell

Substance RN

702691View in Reaxys

Measurement Parameter

Cl

Unit

mL/min/kg

Qualitative value

=

Quantitative value

47.04

Wan, Hong; Bold, Peter; Larsson, Lars-Olof; Ulander, Johan; Peters, Sheila; Loefberg, Boel; Ungell, Anna-Lena; Nagard, Mats; Llinas, Antonio; Current Drug Metabolism; vol. 11; nb. 7; (2010); p. 583 - 594, View in Reaxys 886 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

Bound fraction of compound to rat liver microsomes

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Measurement Parameter

Activity

Measurement Object

Bound fraction

Quantitative value

1

Wan, Hong; Bold, Peter; Larsson, Lars-Olof; Ulander, Johan; Peters, Sheila; Loefberg, Boel; Ungell, Anna-Lena; Nagard, Mats; Llinas, Antonio; Current Drug Metabolism; vol. 11; nb. 7; (2010); p. 583 - 594, View in Reaxys 887 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

In vivo intrinsic clearance of compound in rat liver microsomes

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Measurement Parameter

Clint

Unit

mL/min/kg

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Qualitative value

=

Quantitative value

240

Wan, Hong; Bold, Peter; Larsson, Lars-Olof; Ulander, Johan; Peters, Sheila; Loefberg, Boel; Ungell, Anna-Lena; Nagard, Mats; Llinas, Antonio; Current Drug Metabolism; vol. 11; nb. 7; (2010); p. 583 - 594, View in Reaxys 888 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

Unbound fraction of compound to rat liver microsomes

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Measurement Parameter

fu

Quantitative value

0.25

Wan, Hong; Bold, Peter; Larsson, Lars-Olof; Ulander, Johan; Peters, Sheila; Loefberg, Boel; Ungell, Anna-Lena; Nagard, Mats; Llinas, Antonio; Current Drug Metabolism; vol. 11; nb. 7; (2010); p. 583 - 594, View in Reaxys 889 of 976

890 of 976

Target Name

Gamma-aminobutyric acid receptor subunit delta;+Gamma-aminobutyric acid receptor subunit beta-2;+Gamma-aminobutyric acid receptor subunit alpha-1

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1; Gamma-aminobutyric acid receptor subunit beta-2; Gamma-aminobutyric acid receptor subunit delta

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta:Wild + Gamma-aminobutyric acid receptor subunit beta-2:Wild + Gamma-aminobutyric acid receptor subunit alpha-1:Wild

Substance Action on Target

Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Percent change in recombinant GABA A alpha2beta3gamma2s receptor induced GABA currents (Coapplied with EC5¿10 GABA) in xenopus oocytes upon incubation with 1 uM compound

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Qualitative Results

numbers of oocytes tested = 8

Measurement Parameter

%

Unit

%

Measurement Object

Change in response

Qualitative value

=

Quantitative value

234

Deviation

22

Bioassay Category

Metabolism/Transport

Bioassay Details

Tested for blood to plasma ratio of compound in rat

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Measurement Parameter

BB ratio

Quantitative value

1.2

Wan, Hong; Bold, Peter; Larsson, Lars-Olof; Ulander, Johan; Peters, Sheila; Loefberg, Boel; Ungell, Anna-Lena; Nagard, Mats; Llinas, Antonio; Current Drug Metabolism; vol. 11; nb. 7; (2010); p. 583 - 594, View in Reaxys 891 of 976

Target Name

Gamma-aminobutyric acid receptor subunit delta;+Gamma-aminobutyric acid receptor subunit beta-2;+Gamma-aminobutyric acid receptor subunit alpha-1

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892 of 976

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1; Gamma-aminobutyric acid receptor subunit beta-2; Gamma-aminobutyric acid receptor subunit delta

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta:Wild + Gamma-aminobutyric acid receptor subunit beta-2:Wild + Gamma-aminobutyric acid receptor subunit alpha-1:Wild

Substance Action on Target

Modulator

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Percent change in recombinant mutant GABA A alpha2beta3gamma2s receptor (SHLA) induced GABA currents (Coapplied with EC5-10 GABA) in xenopus oocytes upon incubation with 1 uM compound

Cells/Cell Lines

oocyte

Substance RN

702691View in Reaxys

Qualitative Results

numbers of oocytes tested = 7

Measurement Parameter

%

Unit

%

Measurement Object

Change in response

Qualitative value

=

Quantitative value

200

Deviation

42

Bioassay Category

Metabolism/Transport

Bioassay Details

Ratio of drug concentration in breast milk to that of maternal plasma was determined

Cells/Cell Lines

plasma cell

Substance RN

702691View in Reaxys

Measurement Parameter

Ratio

Quantitative value

0.54

Fatemi, Mohammad H.; Ghorbanzad'E, Mehdi; European Journal of Medicinal Chemistry; vol. 45; nb. 11; (2010); p. 5051 5055, View in Reaxys 893 of 976

Target Name

Cytochrome P450 3A4 [human]

Target Synonyms

1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole sulfoxidase; cholesterol 25-hydroxylase; cyp3a3; cyp3a4; cypiiia3; cypiiia4; cytochrome p450 3a3; cytochrome p450 3a4; cytochrome p450 hlp; cytochrome p450 nf-25; cytochrome p450-pcn1; nifedipine oxidase; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase

Target Uniprot ID

p08684

Target PDB ID

1tqn; 1w0e; 1w0f; 1w0g; 2j0d; 2v0m; 3nxu; 3tjs; 3ua1; 4d6z; 4d75; 4d78; 4d7d; 4i3q; 4i4g; 4i4h; 4k9t; 4k9u; 4k9v; 4k9w; 4k9x; 4ny4; 5a1p; 5a1r; 5te8

Target, Subunit, Species

Cytochrome P450 3A4 [human]

Target Mutant/Chimera Details

Cytochrome P450 3A4 [human]:Wild

Target Species (Bioactivity)

human

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Michaelis-Menten constant of the comopund against human liver microsome cytochrome P450 3A4

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

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894 of 976

Measurement Parameter

pKm

Quantitative value

-2.1892

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Oral lowest lethal dose in human

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Qualitative Results

0.007

Measurement Parameter

LDLo

Unit

mg/kg

Quantitative value

0.007

Heyndrickx; Journal of Analytical Toxicology; vol. 11; nb. 6; (1987); p. 278 - 278, View in Reaxys 895 of 976

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Oral lowest lethal dose in human

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Unit

µg/kg

Qualitative value

=

Quantitative value

430

Heyndrickx; Journal of Analytical Toxicology; vol. 11; nb. 6; (1987); p. 278 - 278, View in Reaxys 896 of 976

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lowest lethal dose of the compound in human upon p.o. administration

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Substance Route of Adm.

oral administration

Qualitative Results

0.43

Measurement Parameter

LDLo

Unit

mg/kg

Measurement Object

Lowest lethal dose

Quantitative value

0.43

Heyndrickx; Journal of Analytical Toxicology; vol. 11; nb. 6; (1987); p. 278 - 278, View in Reaxys 897 of 976

Substance Effect

Toxic

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lowest toxic dose of the compound in human upon p.o. administration

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Substance Route of Adm.

oral administration

Qualitative Results

0.184

Measurement Parameter

TDLo

Unit

mg/kg

Measurement Object

Toxic dose

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Quantitative value

0.184

Heyndrickx; Journal of Analytical Toxicology; vol. 11; nb. 6; (1987); p. 278 - 278, View in Reaxys 898 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Compound was evaluated for the Anti-pentylenetetrazole effect

Substance RN

702691View in Reaxys

Measurement Parameter

Activity

Measurement Object

Antipent effect

Quantitative value

6.5

Aoyama; Suzuki; Ichikawa; Journal of Medicinal Chemistry; vol. 33; nb. 9; (1990); p. 2583 - 2590, View in Reaxys 899 of 976

900 of 976

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Synonyms

bzrap1; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimsbinding protein 1; tspo-associated protein 1; tspoap1

Target Uniprot ID

q9jir0

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

In vitro ability to displace [3H]diazepam from Benzodiazepine receptor in rat cerebral cortex synaptosomal membranes

Biological Species/NCBI ID

Rattus norvegicus

Substance RN

702691View in Reaxys

Measurement Parameter

IC50

Unit

nM

Qualitative value

=

Quantitative value

1.5

Measurement pX

8.82

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Synonyms

bzrap1; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimsbinding protein 1; tspo-associated protein 1; tspoap1

Target Uniprot ID

q9jir0

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1 [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity was evaluated by testing it for displacement of [3H] diazepam from Benzodiazepine receptor of rat forebrain

Biological Species/NCBI ID

Rattus norvegicus

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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901 of 976

Organs/Tissues

brain

Substance RN

702691View in Reaxys

Measurement Parameter

IC50

Unit

nM

Qualitative value

=

Quantitative value

1.5

Measurement pX

8.82

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Compound was evaluated for the Anti-fighting behaviour

Substance RN

702691View in Reaxys

Measurement Parameter

Activity

Measurement Object

Antifighting behaviour

Quantitative value

5.8

Aoyama; Suzuki; Ichikawa; Journal of Medicinal Chemistry; vol. 33; nb. 9; (1990); p. 2583 - 2590, View in Reaxys 902 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Compound was evaluated for the Clined screen test

Substance RN

702691View in Reaxys

Measurement Parameter

Activity

Measurement Object

Clined screen test

Quantitative value

5.5

Aoyama; Suzuki; Ichikawa; Journal of Medicinal Chemistry; vol. 33; nb. 9; (1990); p. 2583 - 2590, View in Reaxys 903 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Activity of the compound was determined by using Clined screen test

Substance RN

702691View in Reaxys

Measurement Parameter

Activity

Quantitative value

5.5

Aoyama; Suzuki; Ichikawa; Journal of Medicinal Chemistry; vol. 33; nb. 9; (1990); p. 2583 - 2590, View in Reaxys 904 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Anti-pentylenetetrazole effect of the compound was determined

Substance RN

702691View in Reaxys

Measurement Parameter

Activity

Quantitative value

6.5

Aoyama; Suzuki; Ichikawa; Journal of Medicinal Chemistry; vol. 33; nb. 9; (1990); p. 2583 - 2590, View in Reaxys 905 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Anti-fighting behaviour of the compound was determined

Substance RN

702691View in Reaxys

Measurement Parameter

Activity

Quantitative value

5.8

Aoyama; Suzuki; Ichikawa; Journal of Medicinal Chemistry; vol. 33; nb. 9; (1990); p. 2583 - 2590, View in Reaxys 906 of 976

Target Name

Cytochrome P450 2C9 [human]

Target Synonyms

(r)-limonene 6-monooxygenase; (s)-limonene 6-monooxygenase; (s)-limonene 7-monooxygenase; cholesterol 25-hydroxylase; cyp2c10; cyp2c9; cypiic9; cytochrome p-450mp; cytochrome p450 2c9; cytochrome p450 mp-4; cytochrome p450 mp-8; cytochrome p450 pb-1; s-mephenytoin 4-hydroxylase

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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2018-04-14 18:48:42


907 of 976

Target Uniprot ID

p11712

Target PDB ID

1og2; 1og5; 1r9o; 4nz2; 5a5i; 5a5j

Target, Subunit, Species

Cytochrome P450 2C9 [human]

Target Mutant/Chimera Details

Cytochrome P450 2C9 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Inhibitor

Bioassay Category

Metabolism/Transport

Bioassay Details

In vitro percent inhibition of human liver microsomes Cytochrome P450 2C9 mediated clearance of compound was determined

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Qualitative Results

Range = 10 - 15 %

Measurement Parameter

% Inhibition

Unit

%

Measurement Object

Cytochrome P450 2C9-mediated metabolism

Quantitative value

10 - 15

Bioassay Category

Pharmacokinetic

Bioassay Details

Half life of the compound in human

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Substance Route of Adm.

intravenous administration

Qualitative Results

Range: 18-26 h

Measurement Parameter

t1/2 el

Unit

hour

Qualitative value

=

Quantitative value

26

Mandrioli, Roberto; Mercolini, Laura; Raggi, Maria Augusta; Current drug metabolism; vol. 9; nb. 8; (2008); p. 827 - 844, View in Reaxys 908 of 976

Bioassay Category

Metabolism/Transport

Bioassay Details

Volume of distribution of compound was determined in human

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Measurement Parameter

Vd

Unit

L/kg

Measurement Object

Volume of distribution

Qualitative value

=

Quantitative value

4.58

Sui, Xiaofan; Sun, Jin; Wu, Xin; Li, Haiyan; Liu, Jianfang; He, Zhonggui; Current Drug Metabolism; vol. 9; nb. 6; (2008); p. 574 - 580, View in Reaxys 909 of 976

Bioassay Category

Metabolism/Transport

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Bioassay Details

Volume of distribution of compound was determined in dog

Biological Species/NCBI ID

dog

Substance RN

702691View in Reaxys

Measurement Parameter

Vd

Unit

L/kg

Measurement Object

Volume of distribution

Qualitative value

=

Quantitative value

13

Sui, Xiaofan; Sun, Jin; Wu, Xin; Li, Haiyan; Liu, Jianfang; He, Zhonggui; Current Drug Metabolism; vol. 9; nb. 6; (2008); p. 574 - 580, View in Reaxys 910 of 976

911 of 976

Target Name

Dihydropteridine reductase [Escherichia coli]

Target Synonyms

dihydropteridine reductase; dihydropteridine reductase, nad(p)h-dependent, oxygen-insensitive; nad(p)h nitroreductase; nad(p)h-dependent oxidoreductase; nfnb; oxygen-insensitive nad(p)h nitroreductase

Target Uniprot ID

a0a024l6h0; a0a094vlp5; a0a0b1jr41; a0a0d8w9r9; a0a0l1cbp1; a0a0l7agg6; a0a0t5xnz1; a0a0u4kvs8; c3tkb7; e2qhd8

Target, Subunit, Species

Dihydropteridine reductase [Escherichia coli]

Target Mutant/Chimera Details

Dihydropteridine reductase [Escherichia coli]:Wild

Target Species (Bioactivity)

Escherichia coli

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Ratio of catalytic activity to that of michaelis-menten constant towards recombinant escherichia coli nitroreductase NfsB in the presence of NADPH (2 mM) incubated for 2 h under anaerobic conditions using nitroreductase assay

Biological Species/NCBI ID

Escherichia coli

Substance RN

702691View in Reaxys

Qualitative Results

kcat/Km not calculated

Measurement Parameter

Qualitative

Measurement Object

kcat/Km

Concomitants: Compound name

NADPH (2 mM)

Concomitants: Compound role

COM

Target Name

Dihydropteridine reductase [Escherichia coli]

Target Synonyms

dihydropteridine reductase; dihydropteridine reductase, nad(p)h-dependent, oxygen-insensitive; nad(p)h nitroreductase; nad(p)h-dependent oxidoreductase; nfnb; oxygen-insensitive nad(p)h nitroreductase

Target Uniprot ID

a0a024l6h0; a0a094vlp5; a0a0b1jr41; a0a0d8w9r9; a0a0l1cbp1; a0a0l7agg6; a0a0t5xnz1; a0a0u4kvs8; c3tkb7; e2qhd8

Target, Subunit, Species

Dihydropteridine reductase [Escherichia coli]

Target Mutant/Chimera Details

Dihydropteridine reductase [Escherichia coli]:Wild

Target Species (Bioactivity)

Escherichia coli

Bioassay Category

In Vitro (Efficacy)

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912 of 976

913 of 976

Bioassay Details

Catalytic activity of compound towards recombinant escherichia coli nitroreductase NfsB in the presence of NADPH (2 mM) incubated for 2 h under anaerobic conditions using nitroreductase assay

Biological Species/NCBI ID

Escherichia coli

Substance RN

702691View in Reaxys

Measurement Parameter

kcat

Unit

min-1

Measurement Object

catalytic activity

Qualitative value

=

Quantitative value

7150

Deviation

30

Concomitants: Compound name

NADPH (2 mM)

Concomitants: Compound role

COM

Target Name

Dihydropteridine reductase [Escherichia coli]

Target Synonyms

dihydropteridine reductase; dihydropteridine reductase, nad(p)h-dependent, oxygen-insensitive; nad(p)h nitroreductase; nad(p)h-dependent oxidoreductase; nfnb; oxygen-insensitive nad(p)h nitroreductase

Target Uniprot ID

a0a024l6h0; a0a094vlp5; a0a0b1jr41; a0a0d8w9r9; a0a0l1cbp1; a0a0l7agg6; a0a0t5xnz1; a0a0u4kvs8; c3tkb7; e2qhd8

Target, Subunit, Species

Dihydropteridine reductase [Escherichia coli]

Target Mutant/Chimera Details

Dihydropteridine reductase [Escherichia coli]:Wild

Target Species (Bioactivity)

Escherichia coli

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Activity of compound (64 uM) towards Escherichia coli DH5 nitroreductase NfsB under anaerobic conditions in presence of NADPH (2 mM) using nitroreductase assay

Biological Species/NCBI ID

Escherichia coli DH5

Substance RN

702691View in Reaxys

Qualitative Results

Activity not calculated

Measurement Parameter

Qualitative

Measurement Object

Activity

Concomitants: Compound name

NADPH (2 mM)

Concomitants: Compound role

COM

Target Name

Dihydropteridine reductase [Salmonella enterica serovar Typhimurium]

Target Synonyms

dihydropteridine reductase

Target Uniprot ID

a0a0d6h528

Target, Subunit, Species

Dihydropteridine reductase [Salmonella enterica serovar Typhimurium]

Target Mutant/Chimera Details

Dihydropteridine reductase [Salmonella enterica serovar Typhimurium]:Wild

Target Species (Bioactivity)

Salmonella enterica serovar Typhimurium

Bioassay Category

In Vitro (Efficacy)

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914 of 976

915 of 976

Bioassay Details

Activity of compound (64 uM) towards Salmonella typhimurium TA1537 nitroreductase NfsB under anaerobic conditions in presence of NADPH (2 mM) using nitroreductase assay

Biological Species/NCBI ID

Salmonella enterica serovar Typhimurium TA 1537

Substance RN

702691View in Reaxys

Qualitative Results

Activity not calculated

Measurement Parameter

Qualitative

Measurement Object

Activity

Concomitants: Compound name

NADPH (2 mM)

Concomitants: Compound role

COM

Target Name

Dihydropteridine reductase [Escherichia coli]

Target Synonyms

dihydropteridine reductase; dihydropteridine reductase, nad(p)h-dependent, oxygen-insensitive; nad(p)h nitroreductase; nad(p)h-dependent oxidoreductase; nfnb; oxygen-insensitive nad(p)h nitroreductase

Target Uniprot ID

a0a024l6h0; a0a094vlp5; a0a0b1jr41; a0a0d8w9r9; a0a0l1cbp1; a0a0l7agg6; a0a0t5xnz1; a0a0u4kvs8; c3tkb7; e2qhd8

Target, Subunit, Species

Dihydropteridine reductase [Escherichia coli]

Target Mutant/Chimera Details

Dihydropteridine reductase [Escherichia coli]:Wild

Target Species (Bioactivity)

Escherichia coli

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Maximum velocity of compound towards recombinant escherichia coli nitroreductase NfsB in the presence of NADPH (2 mM) incubated for 2 h under anaerobic conditions using nitroreductase assay

Biological Species/NCBI ID

Escherichia coli

Substance RN

702691View in Reaxys

Measurement Parameter

Vmax

Unit

µM/min

Measurement Object

Maximum velocity

Qualitative value

=

Quantitative value

5960.01

Deviation

190

Concomitants: Compound name

NADPH (2 mM)

Concomitants: Compound role

COM

Target Name

Dihydropteridine reductase [Enterobacter cloacae]

Target Synonyms

dihydropteridine reductase; nad(p)h nitroreductase; nfnb; nitroreductase

Target Uniprot ID

a0a0j0gyz6; a0a0m3fa73; a0a161gis3

Target, Subunit, Species

Dihydropteridine reductase [Enterobacter cloacae]

Target Mutant/Chimera Details

Dihydropteridine reductase [Enterobacter cloacae]:Wild

Target Species (Bioactivity)

Enterobacter cloacae

Bioassay Category

In Vitro (Efficacy)

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916 of 976

917 of 976

Bioassay Details

Activity of compound (64 uM) towards Enterobacter cloacae nitroreductase NfsB under anaerobic conditions in presence of NADPH (2 mM) using nitroreductase assay

Biological Species/NCBI ID

Enterobacter cloacae

Substance RN

702691View in Reaxys

Qualitative Results

Activity not calculated

Measurement Parameter

Qualitative

Measurement Object

Activity

Concomitants: Compound name

NADPH (2 mM)

Concomitants: Compound role

COM

Target Name

Dihydropteridine reductase [Escherichia coli]

Target Synonyms

dihydropteridine reductase; dihydropteridine reductase, nad(p)h-dependent, oxygen-insensitive; nad(p)h nitroreductase; nad(p)h-dependent oxidoreductase; nfnb; oxygen-insensitive nad(p)h nitroreductase

Target Uniprot ID

a0a024l6h0; a0a094vlp5; a0a0b1jr41; a0a0d8w9r9; a0a0l1cbp1; a0a0l7agg6; a0a0t5xnz1; a0a0u4kvs8; c3tkb7; e2qhd8

Target, Subunit, Species

Dihydropteridine reductase [Escherichia coli]

Target Mutant/Chimera Details

Dihydropteridine reductase [Escherichia coli]:Wild

Target Species (Bioactivity)

Escherichia coli

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Michaelis-Menten constant of compound towards recombinant escherichia coli nitroreductase NfsB in the presence of NADPH (2mM) incubated for 2 h under anaerobic conditions using nitroreductase assay

Biological Species/NCBI ID

Escherichia coli

Substance RN

702691View in Reaxys

Measurement Parameter

Km

Unit

µM

Measurement Object

Michaelis-menten constant

Qualitative value

=

Quantitative value

23.17

Deviation

1.6

Measurement pX

4.63

Concomitants: Compound name

NADPH (2 mM)

Concomitants: Compound role

COM

Target Name

Gamma-aminobutyric acid receptor subunit delta;+Gamma-aminobutyric acid receptor subunit beta-2;+Gamma-aminobutyric acid receptor subunit alpha-1

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1; Gamma-aminobutyric acid receptor subunit beta-2; Gamma-aminobutyric acid receptor subunit delta

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta:Wild + Gamma-aminobutyric acid receptor subunit beta-2:Wild + Gamma-aminobutyric acid receptor subunit alpha-1:Wild

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918 of 976

919 of 976

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity towards GABAA receptor alpha 5 infected in Sf9 cells upon incubation in 50 mM Tris-HCl buffer, pH 7.7 for 90 min at 0 degree C using [3H]-Ro15-4513 (0.5 +/- 1.0 nM) as radioligand with the compound (40 pM to 10 uM) dissolved in 100 ethanol using competition binding assay

Cells/Cell Lines

Sf9

Substance RN

702691View in Reaxys

Substance Dose

= 10 µm

Measurement Parameter

Ki

Unit

nM

Qualitative value

=

Quantitative value

5.3

Measurement pX

8.28

Concomitants: Compound name

[3H]Ro 15-4513

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit delta [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]

Target Synonyms

gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gammaaminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p0c2w5 + p08219

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle]; Gamma-aminobutyric acid receptor subunit delta [taurine cattle]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Ratio of binding affinity towards Central benzodiazepine receptor in bovine cortical membranes in absence of GABA to that of in presence of 50 uM GABA

Biological Species/NCBI ID

taurine cattle

Substance RN

702691View in Reaxys

Measurement Parameter

Ratio

Quantitative value

1.68

Target Name

Gamma-aminobutyric acid receptor subunit delta [human];+Gamma-aminobutyric acid receptor subunit beta-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

o14764 + p47870 + p14867

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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920 of 976

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]; Gamma-aminobutyric acid receptor subunit delta [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity towards Central benzodiazepine receptor in human cortical membrane displacing 0.2 nM [3H]flumazil in 50 mM Tris-citrate buffer at pH 7.4 incubated at 0 degree C for 90 min

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Measurement Parameter

Ki

Unit

nM

Qualitative value

=

Quantitative value

6.5

Deviation

0.5

Measurement pX

8.19

Concomitants: Compound name

[3H]Flumazenil

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit delta [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]

Target Synonyms

gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gammaaminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p0c2w5 + p08219

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle]; Gamma-aminobutyric acid receptor subunit delta [taurine cattle]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity towards Central benzodiazepine receptor in bovine cortical membrane displacing 0.2 nM [3H]flumazil in 50 mM Tris-citrate buffer at pH 7.4 incubated at 0 degree C for 90 min

Biological Species/NCBI ID

taurine cattle

Substance RN

702691View in Reaxys

Measurement Parameter

Ki

Unit

nM

Qualitative value

=

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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921 of 976

922 of 976

923 of 976

Quantitative value

5.17

Deviation

0.2

Measurement pX

8.29

Concomitants: Compound name

[3H]Flumazenil

Concomitants: Compound role

RAD

Target Name

Gamma-aminobutyric acid receptor subunit delta [human];+Gamma-aminobutyric acid receptor subunit beta-2 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

o14764 + p47870 + p14867

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-2 [human]; Gamma-aminobutyric acid receptor subunit delta [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Ratio of binding affinity towards Central benzodiazepine receptor in human cortical membranes in absence of GABA to that of in presence of 50 uM GABA

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Measurement Parameter

Ratio

Quantitative value

1.6

Target Name

Gamma-aminobutyric acid receptor subunit delta;+Gamma-aminobutyric acid receptor subunit beta-2;+Gamma-aminobutyric acid receptor subunit alpha-1

Target Synonyms

gaba(a) receptor subunit delta; gabrd; gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1; Gamma-aminobutyric acid receptor subunit beta-2; Gamma-aminobutyric acid receptor subunit delta

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta:Wild + Gamma-aminobutyric acid receptor subunit beta-2:Wild + Gamma-aminobutyric acid receptor subunit alpha-1:Wild

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Dissociation constant of the compound towards GABAA receptor alpha 1 was determined

Substance RN

702691View in Reaxys

Measurement Parameter

Kd

Unit

nM

Qualitative value

=

Quantitative value

4.5

Measurement pX

8.35

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Dose required to induce sleep in sleep disorder or minor gynaecological surgery patients was determined

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Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Measurement Parameter

Dose

Unit

mg

Measurement Object

Induce sleep in sleep disorder or minor gynaecological surgery patients

Qualitative value

=

Quantitative value

2

William J. Houlihan; Gregory B. Bennett; Annual reports in medicinal chemistry; vol. 13; (1978); p. 21 - 30, View in Reaxys 924 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Dose of the compound required to produce hypnosis in psychiatric patients was determined

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Measurement Parameter

Dose

Unit

mg

Qualitative value

=

Quantitative value

2

Joel G. Berger; Louis C. Iorio; Annual reports in medicinal chemistry; vol. 14; nb. 19; (1979); p. 22 - 30, View in Reaxys 925 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Dose required to induce sleep in normal subjects was determined in patients

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Measurement Parameter

Dose

Unit

mg

Measurement Object

Induce sleep in normal subjects

Qualitative value

=

Quantitative value

1

William J. Houlihan; Gregory B. Bennett; Annual reports in medicinal chemistry; vol. 13; (1978); p. 21 - 30, View in Reaxys 926 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Compound was tested for EEG and behavioural effects in monkeys; Effective

Biological Species/NCBI ID

Cercopithecidae

Substance RN

702691View in Reaxys

Measurement Parameter

Activity

Measurement Object

EEG and behavioural effects in monkeys

Qualitative value

ND

Charles L. Zirkle; Carl Kaiser; Annual reports in medicinal chemistry; vol. 7; (1972); p. 6 - 17, View in Reaxys 927 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Effect of the compound was determined as antiphotoconvulsive effect; more effective than nitrazepam

Substance RN

702691View in Reaxys

Measurement Parameter

Activity

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Qualitative value

ND

R. Ian Fryer; Annual reports in medicinal chemistry; vol. 6; (1970); p. 1 - 14, View in Reaxys 928 of 976

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity of the compound towards benzodiazepine omega 1 receptor

Substance RN

702691View in Reaxys

Measurement Parameter

Activity

Measurement Object

affinity

Quantitative value

2.5

Leslie J. Browne; Kenneth J. Shaw; Annual reports in medicinal chemistry; vol. 26; (1991); p. 1 - 10, View in Reaxys 929 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Effect of the compound was determined as anti-epileptic effect; more effective than nitrazepam

Substance RN

702691View in Reaxys

Measurement Parameter

Activity

Qualitative value

ND

R. Ian Fryer; Annual reports in medicinal chemistry; vol. 6; (1970); p. 1 - 14, View in Reaxys 930 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Amount of the compound required to cause hypnosis in man was determined

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Measurement Parameter

Dose

Unit

mg

Qualitative value

=

Quantitative value

2.5

William J. Houlihan; Gregory B. Bennett; Annual reports in medicinal chemistry; vol. 12; (1977); p. 10 - 19, View in Reaxys 931 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Effect of the compound was determined as anti-epileptic effect; more effective than diazepam

Substance RN

702691View in Reaxys

Measurement Parameter

Activity

Qualitative value

ND

R. Ian Fryer; Annual reports in medicinal chemistry; vol. 6; (1970); p. 1 - 14, View in Reaxys 932 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Effect of the compound was determined as antiphotoconvulsive effect; more effective than diazepam

Substance RN

702691View in Reaxys

Measurement Parameter

Activity

Qualitative value

ND

R. Ian Fryer; Annual reports in medicinal chemistry; vol. 6; (1970); p. 1 - 14, View in Reaxys 933 of 976

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity of the compound towards benzodiazepine omega 2 receptor

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Substance RN

702691View in Reaxys

Measurement Parameter

Activity

Measurement Object

affinity

Quantitative value

1.4

Leslie J. Browne; Kenneth J. Shaw; Annual reports in medicinal chemistry; vol. 26; (1991); p. 1 - 10, View in Reaxys 934 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Amount of the compound required to produce hypnosis in psychiatric patients was determined

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Measurement Parameter

Dose

Unit

mg

Qualitative value

=

Quantitative value

2

Joel G. Berger; Louis C. Iorio; Annual reports in medicinal chemistry; vol. 14; nb. 19; (1979); p. 22 - 30, View in Reaxys 935 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Compound was tested for its hypnotic activity; potent

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Measurement Parameter

Activity

Measurement Object

Hypnotic activity

Qualitative value

ND

A.D. Rudzik; W. Friis; Annual reports in medicinal chemistry; vol. 7; (1972); p. 39 - 46, View in Reaxys 936 of 976

Target Name

Gamma-aminobutyric acid receptor subunit delta [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]

Target Synonyms

gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gammaaminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p0c2w5 + p08219

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle]; Gamma-aminobutyric acid receptor subunit delta [taurine cattle]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

In vitro binding affinity of the compound was evaluated against Gamma-aminobutyric acid A receptor isolated from bovine cerebral cortex by using 3[H] flunitrazepam radioligand; IA denotes inactive

Biological Species/NCBI ID

taurine cattle

Substance RN

702691View in Reaxys

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937 of 976

Measurement Parameter

Activity

Qualitative value

ND

Concomitants: Compound name

[3H]Flunitrazepam

Concomitants: Compound role

RAD

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Compound was tested for hypnotic activity at a dose of 1-3 mg; Effective

Substance RN

702691View in Reaxys

Measurement Parameter

Activity

Qualitative value

ND

Marvin Cohen; Annual reports in medicinal chemistry; vol. 11; (1976); p. 13 - 22, View in Reaxys 938 of 976

Target Name

Translocator protein

Target Synonyms

bzrp; ibp; isoquinoline-binding protein; mbr; mitochondrial benzodiazepine receptor; pbr; peripheral-type benzodiazepine receptor; pkbs; translocator protein; tspo

Target, Subunit, Species

Translocator protein

Target Mutant/Chimera Details

Translocator protein:Wild

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity of the compound towards benzodiazepine omega 3 receptor

Substance RN

702691View in Reaxys

Measurement Parameter

Activity

Measurement Object

affinity

Quantitative value

234

Leslie J. Browne; Kenneth J. Shaw; Annual reports in medicinal chemistry; vol. 26; (1991); p. 1 - 10, View in Reaxys 939 of 976

Target Name

Gamma-aminobutyric acid receptor subunit delta [taurine cattle];+Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle];+Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]

Target Synonyms

gamma-aminobutyric acid receptor subunit delta + gaba(a) receptor subunit beta-2; gabrb2; gamma-aminobutyric acid receptor subunit beta-2 + gaba(a) receptor subunit alpha-1; gabra1; gammaaminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p0c2w5 + p08219

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]; Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle]; Gamma-aminobutyric acid receptor subunit delta [taurine cattle]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit delta [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit beta-2 [taurine cattle]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

In vitro binding affinity of the compound was evaluated against GABA receptor isolated from bovine cerebral cortex by using 3[H] flunitrazepam radioligand; IA denotes inactive

Biological Species/NCBI ID

taurine cattle

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Substance RN

702691View in Reaxys

Qualitative Results

IA

Measurement Parameter

Activity

Qualitative value

NA

Measurement pX

1

Concomitants: Compound name

[3H]Flunitrazepam

Concomitants: Compound role

RAD

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Compound was tested for EEG and behavioral effects in monkeys; Effective

Biological Species/NCBI ID

Cercopithecidae

Substance RN

702691View in Reaxys

Measurement Parameter

Activity

Qualitative value

ND

Charles L. Zirkle; Carl Kaiser; Annual reports in medicinal chemistry; vol. 7; (1972); p. 6 - 17, View in Reaxys 941 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Compound was tested for its effect as an hypnotic agent; effective at a dose of 1-3 mg

Substance RN

702691View in Reaxys

Measurement Parameter

Activity

Qualitative value

ND

Marvin Cohen; Annual reports in medicinal chemistry; vol. 11; (1976); p. 13 - 22, View in Reaxys 942 of 976

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Dose required to induce sleep in normal subjects was determined

Biological Species/NCBI ID

human

Substance RN

702691View in Reaxys

Measurement Parameter

Dose

Unit

mg

Qualitative value

=

Quantitative value

1

William J. Houlihan; Gregory B. Bennett; Annual reports in medicinal chemistry; vol. 13; (1978); p. 21 - 30, View in Reaxys 943 of 976

Target Name

Peripheral-type benzodiazepine receptor-associated protein 1

Target Synonyms

bzrap1; kiaa0612; pbr-ip; peripheral benzodiazepine receptor-interacting protein; peripheral-type benzodiazepine receptor-associated protein 1; prax-1; rbp1; rim-bp1; rimbp1; rims-binding protein 1; tspo-associated protein 1; tspoap1

Target, Subunit, Species

Peripheral-type benzodiazepine receptor-associated protein 1

Target Mutant/Chimera Details

Peripheral-type benzodiazepine receptor-associated protein 1:Wild

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Tested for binding affinity of the compound against benzodiazepine receptor sites in Ligand/ [3H]FLU competition experiment in presence of GABA; Causes a moderate increase in affinity

Substance RN

702691View in Reaxys

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944 of 976

Qualitative Results

Increase in affinity

Measurement Parameter

Activity

Qualitative value

@

Concomitants: Compound name

GABA; [3H]FLU

Concomitants: Compound role

COM; RAD

Bioassay Category

In Vivo (Animal models)

Bioassay Name

In vivo Measurement

Biological Species/NCBI ID

rhesus monkey

Substance RN

702691View in Reaxys

Substance Name

figures 1; 4; 5, page 185, paragraphs 2+4; table 1 - compound: flunitrazepam

Substance Route of Adm.

subcutaneous administration

Substance Dosing Regimen

Single

Measurement Parameter

ED50

Unit

mg/kg

Quantitative value

0.11

Deviation

0.100000

Gerak, Lisa R.; France, Charles P.; Psychopharmacology; vol. 231; nb. 1; (2014); p. 181 - 190, View in Reaxys 945 of 976

946 of 976

Target Name

Carboxylesterase 1 [human]

Target Synonyms

carboxylesterase 1

Target, Subunit, Species

Carboxylesterase 1 [human]

Target Mutant/Chimera Details

Carboxylesterase 1 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Cells/Cell Lines

Sf21 cell line

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

100 µM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

48

Measurement pX

3.97

Concomitants: Compound RN

1281877

Concomitants: Compound name

4-Nitrophenyl acetate

Concomitants: Compound role

SUB

Target Name

Carboxylesterase 2 [human]

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Target Synonyms

carboxylesterase 2

Target, Subunit, Species

Carboxylesterase 2 [human]

Target Mutant/Chimera Details

Carboxylesterase 2 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Cells/Cell Lines

Sf21 cell line

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

100 µM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

42

Measurement pX

3.86

Concomitants: Compound RN

1281877

Concomitants: Compound name

4-Nitrophenyl acetate

Concomitants: Compound role

SUB

Target Name

Arylacetamide deacetylase [human]

Target Synonyms

aadac; arylacetamide deacetylase; dac

Target Uniprot ID

p22760

Target, Subunit, Species

Arylacetamide deacetylase [human]

Target Mutant/Chimera Details

Arylacetamide deacetylase [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Enzymology inhibition

Cells/Cell Lines

Sf21 cell line

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

100 µM

Measurement Parameter

% Inhibition

Qualitative value

NA

Measurement pX

1

Concomitants: Compound RN

1281877

Concomitants: Compound name

4-Nitrophenyl acetate

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Concomitants: Compound role

SUB

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

THP-1 cell line

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

10 μM

Measurement Parameter

% increase

Measurement Object

[3H]cholesterol efflux

Qualitative value

Active

Statistical sgnificance (Qualitative)

NS

Measurement pX

5

Patent; GLASGOW CALEDONIAN UNIVERSITY; GRAHAM, Annette; WO2015/25180; (2015); (A1) English, View in Reaxys 949 of 976

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

THP-1 cell line

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

10 μM

Measurement Parameter

% increase

Measurement Object

[3H]cholesterol efflux

Qualitative value

Active

Statistical sgnificance (Qualitative)

S

Measurement pX

5

Concomitants: Compound RN

10148999

Concomitants: Compound name

apolipoprotein A-I

Concomitants: Compound role

COM

Patent; GLASGOW CALEDONIAN UNIVERSITY; GRAHAM, Annette; WO2015/25180; (2015); (A1) English, View in Reaxys 950 of 976

Target Name

Solute carrier family 22 member 5 [human]

Target Synonyms

high-affinity sodium-dependent carnitine cotransporter; octn2; organic cation/carnitine transporter 2; slc22a5; solute carrier family 22 member 5

Target Uniprot ID

o76082

Target, Subunit, Species

Solute carrier family 22 member 5 [human]

Target Mutant/Chimera Details

Solute carrier family 22 member 5 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Substance Action on Target

Inhibitor

Bioassay Category

Metabolism/Transport

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951 of 976

952 of 976

Cells/Cell Lines

HEK293 cell line

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

200 μM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

92.9

Measurement pX

4.82

Concomitants: Compound RN

606492

Concomitants: Compound name

metformin

Concomitants: Compound role

SUB

Target Name

Solute carrier family 22 member 5 [human]

Target Synonyms

high-affinity sodium-dependent carnitine cotransporter; octn2; organic cation/carnitine transporter 2; slc22a5; solute carrier family 22 member 5

Target Uniprot ID

o76082

Target, Subunit, Species

Solute carrier family 22 member 5 [human]

Target Mutant/Chimera Details

Solute carrier family 22 member 5 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Substance Action on Target

Inhibitor

Bioassay Category

Metabolism/Transport

Cells/Cell Lines

HEK293 cell line

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

20 μM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

74.1

Statistical sgnificance (Qualitative)

S

Measurement pX

5.16

Concomitants: Compound RN

606492

Concomitants: Compound name

metformin

Concomitants: Compound role

SUB

Target Name

Solute carrier family 22 member 5 [human]

Target Synonyms

high-affinity sodium-dependent carnitine cotransporter; octn2; organic cation/carnitine transporter 2; slc22a5; solute carrier family 22 member 5

Target Uniprot ID

o76082

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Target, Subunit, Species

Solute carrier family 22 member 5 [human]

Target Mutant/Chimera Details

Solute carrier family 22 member 5 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HEK293 cell line

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

200 μM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

57.5

Measurement pX

3.83

Concomitants: Compound RN

1618932

Concomitants: Compound name

1-methyl-4-phenylpyridinium

Concomitants: Compound role

SUB

Target Name

Solute carrier family 22 member 5 [human]

Target Synonyms

high-affinity sodium-dependent carnitine cotransporter; octn2; organic cation/carnitine transporter 2; slc22a5; solute carrier family 22 member 5

Target Uniprot ID

o76082

Target, Subunit, Species

Solute carrier family 22 member 5 [human]

Target Mutant/Chimera Details

Solute carrier family 22 member 5 [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Transfected

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

HEK293 cell line

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

20 μM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

5.1

Measurement pX

1

Concomitants: Compound RN

1618932

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Concomitants: Compound name

1-methyl-4-phenylpyridinium

Concomitants: Compound role

SUB

Target Name

UDP-glucuronosyltransferase 1-8

Target Synonyms

a3; gnt1; udp-glucuronosyltransferase 1-8; udp-glucuronosyltransferase 1-h; udp-glucuronosyltransferase 1a8; udpgt 1-8; ugt-1h; ugt1; ugt1*8; ugt1-08; ugt1.8; ugt1a8; ugt1h

Target, Subunit, Species

UDP-glucuronosyltransferase 1-8

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 1-8:Wild

Target Transfection

Transfected

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

20 μM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

14

Measurement pX

1

Concomitants: Compound RN

4890356; 78881

Concomitants: Compound role

SUB; COM

Oda, Shingo; Fujiwara, Ryoichi; Kutsuno, Yuki; Fukami, Tatsuki; Itoh, Tomoo; Yokoi, Tsuyoshi; Nakajima, Miki; Drug Metabolism and Disposition; vol. 43; nb. 6; (2015); p. 812 - 818, View in Reaxys 955 of 976

Target Name

UDP-glucuronosyltransferase 1-8

Target Synonyms

a3; gnt1; udp-glucuronosyltransferase 1-8; udp-glucuronosyltransferase 1-h; udp-glucuronosyltransferase 1a8; udpgt 1-8; ugt-1h; ugt1; ugt1*8; ugt1-08; ugt1.8; ugt1a8; ugt1h

Target, Subunit, Species

UDP-glucuronosyltransferase 1-8

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 1-8:Wild

Target Transfection

Transfected

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

20 μM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

19

Measurement pX

1

Concomitants: Compound RN

4890356; 78881

Concomitants: Compound role

SUB; COM

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Oda, Shingo; Fujiwara, Ryoichi; Kutsuno, Yuki; Fukami, Tatsuki; Itoh, Tomoo; Yokoi, Tsuyoshi; Nakajima, Miki; Drug Metabolism and Disposition; vol. 43; nb. 6; (2015); p. 812 - 818, View in Reaxys 956 of 976

Target Name

UDP-glucuronosyltransferase 1-8

Target Synonyms

a3; gnt1; udp-glucuronosyltransferase 1-8; udp-glucuronosyltransferase 1-h; udp-glucuronosyltransferase 1a8; udpgt 1-8; ugt-1h; ugt1; ugt1*8; ugt1-08; ugt1.8; ugt1a8; ugt1h

Target, Subunit, Species

UDP-glucuronosyltransferase 1-8

Target Mutant/Chimera Details

UDP-glucuronosyltransferase 1-8:Wild

Target Transfection

Transfected

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

20 μM

Measurement Parameter

% Inhibition

Unit

%

Quantitative value

30

Measurement pX

4.33

Concomitants: Compound RN

4890356; 78881

Concomitants: Compound role

SUB; COM

Oda, Shingo; Fujiwara, Ryoichi; Kutsuno, Yuki; Fukami, Tatsuki; Itoh, Tomoo; Yokoi, Tsuyoshi; Nakajima, Miki; Drug Metabolism and Disposition; vol. 43; nb. 6; (2015); p. 812 - 818, View in Reaxys 957 of 976

958 of 976

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2;+Gamma-aminobutyric acid receptor subunit beta-3;+Gamma-aminobutyric acid receptor subunit alpha-2

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-3; gabrb-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-2; gabra-2; gabra2; gamma-aminobutyric acid receptor subunit alpha-2

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-2; Gamma-aminobutyric acid receptor subunit beta-3; Gamma-aminobutyric acid receptor subunit gamma-2

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2:Wild + Gamma-aminobutyric acid receptor subunit beta-3:Wild + Gamma-aminobutyric acid receptor subunit alpha-2:Wild

Substance Action on Target

Radioligand (/ligand)

Substance Effect

binding activity

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity of the compound towards GABA-A receptor alpha2beta3gamma2 using [3H]Ro 15-1788 as radioligand incubated in 10 mM Tris-Hcl for 1 h at RT with pH 7.4

Substance RN

702691View in Reaxys

Measurement Parameter

Ki

Unit

nM

Qualitative value

=

Quantitative value

2.5

Measurement pX

8.6

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2;+Gamma-aminobutyric acid receptor subunit beta-3;+Gamma-aminobutyric acid receptor subunit alpha-3

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960 of 976

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-3; gabrb-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-3; gabra-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-3; Gamma-aminobutyric acid receptor subunit beta-3; Gamma-aminobutyric acid receptor subunit gamma-2

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2:Wild + Gamma-aminobutyric acid receptor subunit beta-3:Wild + Gamma-aminobutyric acid receptor subunit alpha-3:Wild

Substance Action on Target

Radioligand (/ligand)

Substance Effect

binding activity

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity of the compound towards GABA-A receptor alpha3beta3gamma2 using [3H]Ro 15-1788 as radioligand incubated in 10 mM Tris-Hcl for 1 h at RT with pH 7.4

Substance RN

702691View in Reaxys

Measurement Parameter

Ki

Unit

nM

Qualitative value

=

Quantitative value

4.8

Measurement pX

8.32

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2;+Gamma-aminobutyric acid receptor subunit beta-3;+Gamma-aminobutyric acid receptor subunit alpha-1

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-3; gabrb-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-1; gabra-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1; Gamma-aminobutyric acid receptor subunit beta-3; Gamma-aminobutyric acid receptor subunit gamma-2

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2:Wild + Gamma-aminobutyric acid receptor subunit beta-3:Wild + Gamma-aminobutyric acid receptor subunit alpha-1:Wild

Substance Action on Target

Radioligand (/ligand)

Substance Effect

binding activity

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity of the compound towards GABA-A receptor alpha1beta3gamma2 using [3H]Ro 15-1788 as radioligand incubated in 10 mM Tris-Hcl for 1 h at RT with pH 7.4

Substance RN

702691View in Reaxys

Measurement Parameter

Ki

Unit

nM

Qualitative value

=

Quantitative value

5.2

Measurement pX

8.28

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2;+Gamma-aminobutyric acid receptor subunit beta-3;+Gamma-aminobutyric acid receptor subunit alpha-5

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-3; gabrb-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-5; gabra-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-5; Gamma-aminobutyric acid receptor subunit beta-3; Gamma-aminobutyric acid receptor subunit gamma-2

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961 of 976

962 of 976

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2:Wild + Gamma-aminobutyric acid receptor subunit beta-3:Wild + Gamma-aminobutyric acid receptor subunit alpha-5:Wild

Substance Action on Target

Radioligand (/ligand)

Substance Effect

binding activity

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity of the compound towards GABA-A receptor alpha5beta3gamma2 using [3H]Ro 15-1788 as radioligand incubated in 10 mM Tris-Hcl for 1 h at RT with pH 7.4

Substance RN

702691View in Reaxys

Measurement Parameter

Ki

Unit

nM

Qualitative value

=

Quantitative value

2.11

Measurement pX

8.68

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2;+Gamma-aminobutyric acid receptor subunit beta-3;+Gamma-aminobutyric acid receptor subunit alpha-6

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-3; gabrb-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-6; gabra-6; gabra6; gamma-aminobutyric acid receptor subunit alpha-6

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-6; Gamma-aminobutyric acid receptor subunit beta-3; Gamma-aminobutyric acid receptor subunit gamma-2

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2:Wild + Gamma-aminobutyric acid receptor subunit beta-3:Wild + Gamma-aminobutyric acid receptor subunit alpha-6:Wild

Substance Action on Target

Radioligand (/ligand)

Substance Effect

binding activity

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity of the compound towards GABA-A receptor alpha6beta3gamma2 using [3H]Ro 15-4513 as radioligand incubated in 10 mM Tris-Hcl for 1 h at RT with pH 7.4

Substance RN

702691View in Reaxys

Measurement Parameter

Ki

Unit

nM

Qualitative value

>

Quantitative value

10

Measurement pX

8

Target Name

GABA-A receptor

Target Synonyms

gaba-a receptor; gaba-a receptor activity; ionotropic gaba receptor

Target, Subunit, Species

GABA-A receptor

Target Mutant/Chimera Details

GABA-A receptor:Wild

Substance Action on Target

Agonist

Substance Effect

agonistic activity

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Agonistic activity of the compound towards GABAA receptor

Substance RN

702691View in Reaxys

Qualitative Results

Not Published

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963 of 976

964 of 976

Measurement Parameter

Qualitative

Qualitative value

Not Published

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit alpha-2 [human]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-2; gabra2; gamma-aminobutyric acid receptor subunit alpha-2

Target Uniprot ID

p18507 + p28472 + p47869

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-2 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-2 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Radioligand (/ligand)

Substance Effect

binding activity

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity towards gamma-aminobutyric acid (GABA) A receptor, alpha2beta3gamma2 with 10 mM Tris-HCl pH 7.4 using [3H]Ro15-1788 upon incubation for 1 h at RT

Substance RN

702691View in Reaxys

Measurement Parameter

Qualitative

Measurement Object

Ki

Qualitative value

Not Published

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit alpha-5 [human]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-5; gabra5; gamma-aminobutyric acid receptor subunit alpha-5

Target Uniprot ID

p18507 + p28472 + p31644

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-5 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-5 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Radioligand (/ligand)

Substance Effect

binding activity

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity towards gamma-aminobutyric acid (GABA) A receptor, alpha5beta3gamma2 with 10 mM Tris-HCl pH 7.4 using [3H]Ro15-1788 upon incubation for 1 h at RT

Substance RN

702691View in Reaxys

Measurement Parameter

Qualitative

Measurement Object

Ki

Qualitative value

Not Published

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965 of 976

966 of 976

967 of 976

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit alpha-3 [human]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-3; gabra3; gamma-aminobutyric acid receptor subunit alpha-3

Target Uniprot ID

p18507 + p28472 + p34903

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-3 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-3 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Radioligand (/ligand)

Substance Effect

binding activity

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity towards gamma-aminobutyric acid (GABA) A receptor, alpha3beta3gamma2 using with 10 mM Tris-HCl pH 7.4 [3H]Ro15-1788 upon incubation for 1 h at RT using Tris-HCl as radioligand AT pH 7.5

Substance RN

702691View in Reaxys

Measurement Parameter

Qualitative

Measurement Object

Ki

Qualitative value

Not Published

Target Name

Gamma-aminobutyric acid receptor subunit beta-3;+Gamma-aminobutyric acid receptor subunit alpha-6;+GABA-A receptor (Gamma 3)

Target Synonyms

gaba(a) receptor subunit beta-3; gabrb-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-6; gabra-6; gabra6; gamma-aminobutyric acid receptor subunit alpha-6 + gaba-a receptor (gamma 3)

Target, Subunit, Species

GABA-A receptor (Gamma 3); Gamma-aminobutyric acid receptor subunit alpha-6; Gamma-aminobutyric acid receptor subunit beta-3

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit beta-3:Wild + Gamma-aminobutyric acid receptor subunit alpha-6:Wild + GABA-A receptor (Gamma 3):Wild

Substance Action on Target

Radioligand (/ligand)

Substance Effect

binding activity

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity towards gamma-aminobutyric acid (GABA) A receptor, alpha6beta3gamma3 using with 10 mM Tris-HCl pH 7.4 [3H]Ro15-1788 upon incubation for 1 h at RT

Substance RN

702691View in Reaxys

Measurement Parameter

Qualitative

Measurement Object

Ki

Qualitative value

Not Published

Target Name

Gamma-aminobutyric acid receptor subunit gamma-2 [human];+Gamma-aminobutyric acid receptor subunit beta-3 [human];+Gamma-aminobutyric acid receptor subunit alpha-1 [human]

Target Synonyms

gaba(a) receptor subunit gamma-2; gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 + gaba(a) receptor subunit beta-3; gabrb3; gamma-aminobutyric acid receptor subunit beta-3 + gaba(a) receptor subunit alpha-1; gabra1; gamma-aminobutyric acid receptor subunit alpha-1

Target Uniprot ID

p18507 + p28472 + p14867

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968 of 976

969 of 976

Target PDB ID

4cof

Target, Subunit, Species

Gamma-aminobutyric acid receptor subunit alpha-1 [human]; Gamma-aminobutyric acid receptor subunit beta-3 [human]; Gamma-aminobutyric acid receptor subunit gamma-2 [human]

Target Mutant/Chimera Details

Gamma-aminobutyric acid receptor subunit gamma-2 [human]:Wild + Gamma-aminobutyric acid receptor subunit beta-3 [human]:Wild + Gamma-aminobutyric acid receptor subunit alpha-1 [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Radioligand (/ligand)

Substance Effect

binding activity

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Binding affinity towards gamma-aminobutyric acid (GABA) A receptor, alpha1beta3gamma2 with 10 mM Tris-HCl pH 7.4 using [3H]Ro15-1788 as radioligand upon incubation for 1 h at RT

Substance RN

702691View in Reaxys

Measurement Parameter

Qualitative

Measurement Object

Ki

Qualitative value

Not Published

Target Name

GABA-A receptor

Target Synonyms

gaba-a receptor; gaba-a receptor activity; ionotropic gaba receptor

Target, Subunit, Species

GABA-A receptor

Target Mutant/Chimera Details

GABA-A receptor:Wild

Substance Action on Target

Inhibitor

Substance Effect

inhibitory activity

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Inhibitory activity of the compound against GABAA receptor

Substance RN

702691View in Reaxys

Qualitative Results

Not Published

Measurement Parameter

Qualitative

Qualitative value

Not Published

Target Name

Protein kinase C epsilon type

Target Synonyms

protein kinase c epsilon type

Target, Subunit, Species

Protein kinase C epsilon type

Target Mutant/Chimera Details

Protein kinase C epsilon type:Wild

Substance Action on Target

Inhibitor

Substance Effect

inhibitory activity

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Effective concentration of compound required for modulation of GABA-stimulated currents in HEK 293 cell line expressing PROTEIN KINASE C EPSILON using ELISA method

Cells/Cell Lines

HEK293 cell line

Substance RN

702691View in Reaxys

Measurement Parameter

EC50

Unit

nM

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970 of 976

971 of 976

Measurement Object

Gaba-Stimulated Currents

Qualitative value

=

Quantitative value

150

Measurement pX

6.82

Target Name

Translocator protein

Target Synonyms

bzrp; ibp; isoquinoline-binding protein; mbr; mitochondrial benzodiazepine receptor; pbr; peripheral-type benzodiazepine receptor; pkbs; translocator protein; tspo

Target, Subunit, Species

Translocator protein

Target Mutant/Chimera Details

Translocator protein:Wild

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Cells/Cell Lines

C6

Cell Fraction

Lysate

Substance RN

702691View in Reaxys

Substance Name

3H-flunitrazepam

Measurement Parameter

Ki

Unit

nM

Qualitative value

>

Quantitative value

10000

Measurement pX

1

Concomitants: Compound RN

4264456

Concomitants: Compound name

%3&H-PK 11195

Concomitants: Compound role

RAD

Bioassay Category

In Vitro (Efficacy)

Biological Species/NCBI ID

Sprague Dawley rat

Organs/Tissues

cerebellum

Cells/Cell Lines

granule cell

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0.1 μM

Measurement Parameter

% Efficacy

Unit

%

Measurement Object

chloride channel conductance

Quantitative value

17

Concomitants: Compound RN

906818

Concomitants: Compound name

4-aminobutyric acid

Concomitants: Compound role

IND

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Gatta, Elena; Cupello, Aroldo; Di Braccio, Mario; Grossi, Giancarlo; Robello, Mauro; Scicchitano, Francesca; Russo, Emilio; De Sarro, Giovambattista; Journal of Molecular Neuroscience; vol. 60; nb. 4; (2016); p. 539 - 547, View in Reaxys 972 of 976

Substance Effect

Anticonvulsant

Bioassay Category

In Vivo (Animal models)

Biological Species/NCBI ID

DBA 2 mouse

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0.11 - 0.41 μmol/kg

Substance Route of Adm.

intraperitoneal administration

Measurement Parameter

ED50

Unit

μmol/kg

Measurement Object

ED 50 for clonic phase

Quantitative value

0.22

Gatta, Elena; Cupello, Aroldo; Di Braccio, Mario; Grossi, Giancarlo; Robello, Mauro; Scicchitano, Francesca; Russo, Emilio; De Sarro, Giovambattista; Journal of Molecular Neuroscience; vol. 60; nb. 4; (2016); p. 539 - 547, View in Reaxys 973 of 976

Substance Effect

Anticonvulsant

Bioassay Category

In Vivo (Animal models)

Biological Species/NCBI ID

DBA 2 mouse

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Substance Dose

0.09 - 0.36 μmol/kg

Substance Route of Adm.

intraperitoneal administration

Measurement Parameter

ED50

Unit

μmol/kg

Measurement Object

ED50 for Tonic phase

Quantitative value

0.18

Gatta, Elena; Cupello, Aroldo; Di Braccio, Mario; Grossi, Giancarlo; Robello, Mauro; Scicchitano, Francesca; Russo, Emilio; De Sarro, Giovambattista; Journal of Molecular Neuroscience; vol. 60; nb. 4; (2016); p. 539 - 547, View in Reaxys 974 of 976

Target Name

GABA-A receptor [Sprague Dawley rat]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [Sprague Dawley rat]

Target Mutant/Chimera Details

GABA-A receptor [Sprague Dawley rat]:Wild

Target Species (Bioactivity)

Sprague Dawley rat

Target Transfection

Non Transfected

Substance Action on Target

Agonist

Bioassay Category

In Vitro (Efficacy)

Biological Species/NCBI ID

Sprague Dawley rat

Organs/Tissues

brain

Cells/Cell Lines

Synaptosomal cell

Substance RN

702691View in Reaxys

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975 of 976

976 of 976

Substance Name

flunitrazepam

Measurement Parameter

% Increase

Measurement Object

chloride uptake

Qualitative value

Active

Target Name

GABA-A receptor [taurine cattle]

Target Synonyms

gaba-a receptor

Target, Subunit, Species

GABA-A receptor [taurine cattle]

Target Mutant/Chimera Details

GABA-A receptor [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Target Transfection

Non Transfected

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Biological Species/NCBI ID

taurine cattle

Organs/Tissues

brain cortex

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Substance Name

flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

5.2

Measurement pX

8.28

Concomitants: Compound RN

4763661

Concomitants: Compound name

flumazenil

Concomitants: Compound role

RAD

Target Name

GABA-A receptor [human]

Target Synonyms

ionotropic gamma aminobutyric acid a receptor

Target, Subunit, Species

GABA-A receptor [human]

Target Mutant/Chimera Details

GABA-A receptor [human]:Wild

Target Species (Bioactivity)

human

Target Transfection

Non Transfected

Substance Action on Target

Inhibitor

Bioassay Category

In Vitro (Efficacy)

Biological Species/NCBI ID

human

Organs/Tissues

brain cortex

Cell Fraction

Membrane

Substance RN

702691View in Reaxys

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Substance Name

flunitrazepam

Measurement Parameter

Ki

Unit

nM

Quantitative value

6.4

Measurement pX

8.19

Concomitants: Compound RN

4763661

Concomitants: Compound name

flumazenil

Concomitants: Compound role

COM

Reaxys ID 6441871 View in Reaxys

3/12 *H(1+)

Linear Structure Formula: C16H12FN3O3 Molecular Formula: C16H12FN3O3*H Molecular Weight: 314.296 Type of Substance: heterocyclic InChI Key: PPTYJKAXVCCBDU-UHFFFAOYSA-O Note:

O N O

N

N F

O

H+

Substance Label (1) Label References 50*H+

Seiler; Zimmermann; Arzneimittel-Forschung/Drug Research; vol. 33; nb. 11; (1983); p. 1519 - 1522, View in Reaxys

Druglikeness (1) 1 of 1

LogP

2.349

H Bond Donors

0

H Bond Acceptors

3

Rotatable Bonds

2

TPSA

78.49

Lipinski Number

4

Veber Number

2

Dissociation Exponent (1) 1 of 1

Dissociation Exponent (pK)

1.87

Dissociation Group

N(1+)-H

Temperature (Dissociation Exponent) [°C]

25

Solvent (Dissociation Exponent)

H2O; ethanol

Method (Dissociation Exponent)

spectrophotometric

Type (Dissociation Exponent)

a1/apparent

Comment (Dissociation Exponent)

Ratio of solvents: 98:2

Seiler; Zimmermann; Arzneimittel-Forschung/Drug Research; vol. 33; nb. 11; (1983); p. 1519 - 1522, View in Reaxys Electrochemical Behaviour (1)

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Description (Electrochemical Behaviour)

References

Electrolytic dissoci- Seiler; Zimmermann; Arzneimittel-Forschung/Drug Research; vol. 33; nb. 11; (1983); p. 1519 - 1522, View in Reaxys ation / protonation equilibrium

Reaxys ID 27883497 View in Reaxys

4/12

O N

3H

Chemical Name: [3H]-flunitrazepam Linear Structure Formula: C16H11 (3)HFN3O3 Molecular Formula: C16H12FN3O3 Molecular Weight: 315.28 InChI Key: PPTYJKAXVCCBDU-CNRUNOGKSA-N Note:

N

F N O

O

Druglikeness (1) 1 of 1

LogP

2.349

H Bond Donors

0

H Bond Acceptors

3

Rotatable Bonds

2

TPSA

78.49

Lipinski Number

4

Veber Number

2

Reaxys ID 32097874 View in Reaxys

5/12 Chemical Name: [3H]-flunitrazepam Linear Structure Formula: C16H11 (3)HFN3O3 Molecular Formula: C16H12FN3O3 Molecular Weight: 315.28 InChI Key: PPTYJKAXVCCBDU-FIRFLZKJSA-N Note:

O N 3H

O

N

N

O F

Druglikeness (1) 1 of 1

LogP

2.349

H Bond Donors

0

H Bond Acceptors

3

Rotatable Bonds

2

TPSA

78.49

Lipinski Number

4

Veber Number

2

Reaxys ID 9813319 View in Reaxys

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

6/12

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2H

2H

Chemical Name: flunitrazepam-d7 Linear Structure Formula: C16H5D7FN3O3 Molecular Formula: C16H12FN3O3 Molecular Weight: 320.232 Type of Substance: heterocyclic InChI Key: PPTYJKAXVCCBDU-AAYPNNLASA-N Note:

2H

O N

O

N

N F

2H

O

2H 2H

2H

Druglikeness (1) 1 of 1

LogP

2.349

H Bond Donors

0

H Bond Acceptors

3

Rotatable Bonds

2

TPSA

78.49

Lipinski Number

4

Veber Number

2

Mass Spectrometry (2) Description (Mass References Spectrometry) LCMS (Liquid chromatography mass spectrometry); Tandem mass spectrometry; QIT (quadrupole ion trap); Spectrum

Dresen, Sebastian; Kneisel, Stefan; Weinmann, Wolfgang; Zimmermann, Ralf; Auwarter, Volker; Journal of Mass Spectrometry; vol. 46; nb. 2; (2011); p. 163 - 171, View in Reaxys

spectrum; chemical ionization (CI)

Kratzsch, Carsten; Tenberken, Oliver; Peters, Frank T.; Weber, Armin A.; Kraemer, Thomas; Maurer, Hans H.; Journal of Mass Spectrometry; vol. 39; nb. 8; (2004); p. 856 - 872, View in Reaxys

Reaxys ID 32291059 View in Reaxys

7/12

O N

Chemical Name: benzodiazepine flunitrazepam Linear Structure Formula: C9H8N2*C16H12FN3O3 Molecular Formula: C9H8N2*C16H12FN3O3 Molecular Weight: 457.464 InChI Key: ZAXIUWFOWWOOLG-UHFFFAOYSA-N Note:

N N N H

F O

N O

Druglikeness (1) 1 of 1

H Bond Donors

1

H Bond Acceptors

5

Rotatable Bonds

2

TPSA

102.88

Lipinski Number

3

Veber Number

2

Reaxys ID 8389175 View in Reaxys

8/12 Chemical Name: flunitrazepam; poly(ethylene glycol) 200; mixture of Type of Substance: mixture (composition partially given)

No Structure

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Composition: Comp. Name: flunitrazepam; poly(ethylene glycol) 200 Composition: Comp. Conc.: 1 weight percent; 99 weight percent Medchem (1) 1 of 1

Bioassay Category

In Vivo (Animal models)

Bioassay Details

repeated dose toxicityNew Zealand/lop ear cross rabbit

Substance RN

8389175View in Reaxys

Substance Dose

30 μl

Substance Route of Adm.

intranasal administration

Qualitative Results

no adverse clinical signs of toxicity; no gross pathological findings related to treatment; no microscopic abnormalities in brain; flattening of olfactory epithelium

Measurement Parameter

Qualitative

Qualitative value

ND

Hjortkjaer, Rolf K.; Bechgaard, Erik; Gizurarson, Sveinbjoern; Suzdak, Carol; McDonald; Greenough; Journal of Pharmacy and Pharmacology; vol. 51; nb. 4; (1999); p. 377 - 383, View in Reaxys

Reaxys ID 8389177 View in Reaxys

9/12 Chemical Name: flunitrazepam; poly(ethylene glycol) 200; glycofurolum 75; mixture of Type of Substance: mixture (composition partially given) Composition: Comp. Name: flunitrazepam; poly(ethylene glycol) 200, 70 percent; glycofurolum 75, 30 percent; mixture of Composition: Comp. Conc.: 1 weight percent; 99 weight percent

No Structure

Medchem (1) 1 of 1

Bioassay Category

In Vivo (Animal models)

Bioassay Details

repeated dose toxicityNew Zealand/lop ear cross rabbit

Substance RN

8389177View in Reaxys

Substance Dose

30 μl

Substance Route of Adm.

intranasal administration

Qualitative Results

no adverse clinical signs of toxicity; no gross pathological findings related to treatment; no microscopic abnormalities in brain; inflammatory cells in middle part of nasal cavity; flattening and focal inflammation of olfactory epithelium

Measurement Parameter

Qualitative

Qualitative value

ND

Hjortkjaer, Rolf K.; Bechgaard, Erik; Gizurarson, Sveinbjoern; Suzdak, Carol; McDonald; Greenough; Journal of Pharmacy and Pharmacology; vol. 51; nb. 4; (1999); p. 377 - 383, View in Reaxys

Reaxys ID 8827787 View in Reaxys

10/12 Chemical Name: flunitrazepam; flumazenil; mixture of Type of Substance: mixture (composition partially given) Composition: Comp. Name: flunitrazepam; flumazenil

No Structure Medchem (1) 1 of 1

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

expression of α1 subunit protein of GABAA receptorprimary cerebellar granule cells from SpragueDawley ratsWestern blotting; optical density readings, ECL=enhanced chemiluminiscence

Substance RN

8827787View in Reaxys

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Substance Dose

1 μmol/l

Qualitative Results

no change in the expression of the GABAA receptor α1 subunit protein

Measurement Parameter

Qualitative

Qualitative value

ND

Brown, Maria J.; Bristow, David R.; British Journal of Pharmacology; vol. 118; nb. 5; (1996); p. 1103 - 1110, View in Reaxys

Reaxys ID 8827788 View in Reaxys

11/12 Chemical Name: flunitrazepam; α-aminobutyric acid; mixture of Type of Substance: mixture (composition partially given) Composition: Comp. Name: flunitrazepam; 4-amino-n-butyric acid

No Structure Medchem (1) 1 of 1

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

expression of α1 subunit protein of GABAA receptorprimary cerebellar granule cells from SpragueDawley ratsWestern blotting; optical density readings, ECL (enhanced chemiluminiscence) detection for GABAamp; receptor protein subunits

Substance RN

8827788View in Reaxys

Qualitative Results

decrease in the expression of the GABAA receptor α1 subunit protein, not significantly different from flunitrazepam (1 μM) alone, at a lower doses of flunitrazepam (1 and 10 nM) the downregulation also mirrored the effect of flunitrazepam alone

Measurement Parameter

Qualitative

Qualitative value

ND

Brown, Maria J.; Bristow, David R.; British Journal of Pharmacology; vol. 118; nb. 5; (1996); p. 1103 - 1110, View in Reaxys

Reaxys ID 8827790 View in Reaxys

12/12 Chemical Name: flunitrazepam; bicuculline; mixture of Type of Substance: mixture (composition partially given) Composition: Comp. Name: bicuculline; flunitrazepam

No Structure Medchem (1) 1 of 1

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

expression of α1 subunit protein of GABAA receptorprimary cerebellar granule cells from SpragueDawley ratsWestern blotting; optical density readings, ECL (enhanced chemiluminescence) used for detection of GABAA receptor subunits proteins

Substance RN

8827790View in Reaxys

Qualitative Results

decrease in the expression of the GABAA receptor α1 subunit protein, not significantly different from the effect of flunitrazepam alone

Measurement Parameter

Qualitative

Qualitative value

ND

Brown, Maria J.; Bristow, David R.; British Journal of Pharmacology; vol. 118; nb. 5; (1996); p. 1103 - 1110, View in Reaxys

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