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6 reactions in Reaxys
2018-05-13 18h:50m:23s (UTC)
O
1. Query
Cl
Search as: Product, As drawn, No mixtures ))
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
1/3
2018-05-13 18:51:24
H Cl
O Cl Cl
O
Rx-ID: 749694 View in Reaxys 1/6 Yield
Conditions & References
77 %
With aluminum (III) chloride in dichloromethane, Time= 2h, T= 0 °C Mayer; Wimmer; Dillon-Carter; Partilla; Burchardt; Mihovilovic; Baumann; Sitte; British Journal of Pharmacology; (2016); p. 2657 - 2668 View in Reaxys With carbon disulfide, aluminium trichloride Dhami et al.; Journal of Scientific and Industrial Research; vol. 18B; (1959); p. 393 View in Reaxys With aluminium trichloride Sonawane, Harikisan; Bellur, Nanjundiah S.; Kulkarni, Dilip G.; Ayyangar, Nagaraj R.; Tetrahedron; vol. 50; nb. 4; (1994); p. 1243 - 1260 View in Reaxys
Cl
Cl
O
Rx-ID: 41668272 View in Reaxys 2/6 Yield
Conditions & References
90 %
With [hydroxy(tosyloxy)iodo]benzene, water, toluene-4-sulfonic acid in acetonitrile, Time= 17h, T= 20 °C Jobin-Des Lauriers, Antoine; Legault, Claude Y.; Organic Letters; vol. 18; nb. 1; (2016); p. 108 - 111 View in Reaxys
Cl
NH 2 Cl
O O
Rx-ID: 43792756 View in Reaxys 3/6 Yield 91 %
Conditions & References 3 : Example 3 Equipped with a stirrer, thermometer, reflux condenser, dropping funnel in the reaction container, adding stannous chloride 2.43mol, toluene 1.2L, reducing the temperature of the solution to 5 °C, dropwise 2-chloroprop amide 2.1mol were added. The dropping time was controlled at 3 h and the stirring speed was maintained at 180 rpm for 9 h, then mixture was poured into the 2L the mass fraction of 25percent sodium chloride solution, the temperature of the solution is reduced to 4 °C, separating the organic layer, the water layer is extracted with toluene 6 time, combined with the organic layer, used for quality score for sequentially 40percent solution of sodium carbonate, sodium sulfate solution, 1.8kPa vacuum distillation, to obtain oil solvent is recovered, reducing the temperature of the solution to 12 - - 15°C, precipitated solid, by adding the mass fraction is 98percent cyclohexane solution, maintaining the stirring speed 230rpm, filtering, active alumina dehydration, get white solid 1-P-tolyl-2chloro-1-propanone 349.71g, yield 91percent. With tin(ll) chloride, Time= 14h, T= 5 °C , Reflux, Temperature, Concentration Patent; Chengdu East Power Technology Co., Ltd. Al; Chu, donghong; (5 pag.); CN105481665; (2016); (A) Chinese View in Reaxys
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
2/3
2018-05-13 18:51:24
O
Cl
O
Rx-ID: 10119768 View in Reaxys 4/6 Yield
Conditions & References
94 %
With Aluminum(III) chloride hexahydrate, urea-hydrogen peroxide, 1-butyl-3-methylimidazolium Tetrafluoroborate, Time= 6h, T= 60 °C Jong, Chan Lee; Hyun, Jung Park; Synthetic Communications; vol. 36; nb. 6; (2006); p. 777 - 780 View in Reaxys
70 %
With N-chloro-succinimide, urea-hydrogen peroxide, 1-butyl-3-methylimidazolium Tetrafluoroborate, T= 60 °C Lee, Jong Chan; Park, Hyun Jung; Synthetic Communications; vol. 37; nb. 1; (2007); p. 87 - 90 View in Reaxys
H Cl
Cl Cl O
O
Rx-ID: 3537433 View in Reaxys 5/6 Yield
Conditions & References With aluminium trichloride Sonawane, Harikisan; Bellur, Nanjundiah S.; Kulkarni, Dilip G.; Ayyangar, Nagaraj R.; Tetrahedron; vol. 50; nb. 4; (1994); p. 1243 - 1260 View in Reaxys
HO
Cl
O
Rx-ID: 2084912 View in Reaxys 6/6 Yield 94 %
Conditions & References With N,N-dichloro-p-toluenesulfonamide in acetonitrile, Time= 1h, T= 30 °C Kim, Yong Hae; Lee, In Sang; Lim, Sang Chul; Chemistry Letters; nb. 7; (1990); p. 1125 - 1128 View in Reaxys
Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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2018-05-13 18:51:24