N-ethyl-1-phenylcyclohexan-1-amine (Eticyclidine) [CAS 2201-15-2; InChIKey IFYLVUHLOOCYBG-UHF

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NH

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6 reactions in Reaxys

2016-03-25 07h:12m:24s (EST)

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O

hydrogen

HN

Rx-ID: 19033188 View in Reaxys 1/6 Yield

Conditions & References Reaction Steps: 2 1: concd. HCl / H2O 2: benzene / 0.5 h / Heating With hydrogenchloride in water, benzene Kalir; Teomy; Amir; Fuchs; Lee; Holsztynska; Rocki; Domino; Journal of Medicinal Chemistry; vol. 27; nb. 10; (1984); p. 1267 - 1271 View in Reaxys

HN

Li

HN N

Rx-ID: 1244417 View in Reaxys 2/6 Yield

Conditions & References in diethyl ether, Heating Kalir; Edery; Pelah; Balderman; Porath; Journal of medicinal chemistry; vol. 12; nb. 3; (1969); p. 473 - 477 View in Reaxys in benzene, Time= 0.5h, Heating Kalir; Teomy; Amir; Fuchs; Lee; Holsztynska; Rocki; Domino; Journal of Medicinal Chemistry; vol. 27; nb. 10; (1984); p. 1267 - 1271 View in Reaxys

O

polymethylhydrosiloxane

HN

Rx-ID: 22665754 View in Reaxys 3/6 Yield

Conditions & References Reaction Steps: 2 1: (i) aq. HCl, (ii) /BRN= 4652394/ 2: diethyl ether / Heating in diethyl ether Kalir; Edery; Pelah; Balderman; Porath; Journal of medicinal chemistry; vol. 12; nb. 3; (1969); p. 473 - 477 View in Reaxys

HN

HN O

Rx-ID: 322305 View in Reaxys 4/6 Yield

Conditions & References With lithium aluminium tetrahydride, diethyl ether, benzene Chiavarelli et al.; Gazzetta Chimica Italiana; vol. 83; (1953); p. 347,354 View in Reaxys

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HN HO

Rx-ID: 22034529 View in Reaxys 5/6 Yield

Conditions & References Reaction Steps: 2 1: H2SO4; acetic acid 2: LiAlH4; benzene; diethyl ether With lithium aluminium tetrahydride, diethyl ether, sulfuric acid, acetic acid, benzene Chiavarelli et al.; Gazzetta Chimica Italiana; vol. 83; (1953); p. 347,354 View in Reaxys

HN

Rx-ID: 7716471 View in Reaxys 6/6 Yield

Conditions & References N-Cyclohexyliden-aethylamin, Phenyl-Li, Et2O <Δ> Maddox,V.H. et al.; J. Med. Chem.; vol. 8; (1965); p. 230 - 235 View in Reaxys 1-Phenylcyclohexylamin, 1) Ac2O, 2) LiAlH4 Bailey; Journal of Pharmaceutical Sciences; vol. 67; nb. 6; (1978); p. 885 - 886 View in Reaxys N-Ethyl-cyclohexancarbonitril, Phenyl-Li Bailey; Journal of Pharmaceutical Sciences; vol. 67; nb. 6; (1978); p. 885 - 886 View in Reaxys LiAlH4-Reduktion des entspr. Amids Patent; Tanabe; JP1908767; (1960); ; vol. 69; nb. 10195f; (1968) View in Reaxys Phenyllithium, Cyclohexyliden-aethyl-amin, Ae. Patent; Parke, Davis u.Co.; US3097136; (1960); ; vol. 59; nb. 13881; (1963) View in Reaxys N-Aethyl-cyclohexylidenamin, Phenyl-Li Patent; Godefroi, Parcell (Parke, Davis Co.); US3145229; (1960); ; vol. 61; nb. 9434a; (1964) View in Reaxys 1-Aethylamino-cyclohexancarbonitril, Phenyl-Li Patent; Godefroi, Parcell (Parke, Davis Co.); US3145229; (1960); ; vol. 61; nb. 9434a; (1964) View in Reaxys 1-Phenyl-cyclohexylamin II, Eg., Red. an Raney-Ni Patent; Tanabe Seiyaku Co.Ltd.; JP652662; (1959); ; vol. 58; nb. 13842; (1963) View in Reaxys nach bek.Methode Brine; Williams; Boldt; Carroll; Journal of Heterocyclic Chemistry; vol. 16; nb. 7; (1979); p. 1425 - 1429

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View in Reaxys entspr. Literaturzitat 7 Kalir et al.; European Journal of Medicinal Chemistry; vol. 13; (1978); p. 17,18 View in Reaxys N-Ethylphenylcyclohexylamin, Tritium, PdO2 Kalir et al.; European Journal of Medicinal Chemistry; vol. 13; (1978); p. 17,18 View in Reaxys Aethyl-cyclohexyliden-amin, Phenyl-Li, Et2O Patent; Parke; Davis and Co.; GB861350; (1958); ; vol. 55; nb. 17583; (1961) View in Reaxys Aethyl-benzyl-(1-phenyl-cyclohexyl)-amin-formiat, H2 <Pd/C>, MeOH Patent; Parke; Davis and Co.; GB861350; (1958); ; vol. 55; nb. 17583; (1961) View in Reaxys Essigsaeure-(1-phenyl-cyclohexyl)-amid, LiAlH4, Et2O Patent; Parke; Davis and Co.; GB861350; (1958); ; vol. 55; nb. 17583; (1961) View in Reaxys 1,5-Dibrom-pentan, 1) Li, Et2O, 2) Aethyl-(α-chlor-benzyliden)-amin Patent; Parke; Davis and Co.; GB861350; (1958); ; vol. 55; nb. 17583; (1961) View in Reaxys 1-Aethylamino-cyclohexan-1-carbonsaeurenitril, Phenyl-Li, Et2O Patent; Parke; Davis and Co.; GB861350; (1958); ; vol. 55; nb. 17583; (1961) View in Reaxys

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