1-phenethylpiperazine, Substances (5) Details

Query Query

Results

Date

5 substances in Reaxys

2016-05-23 22h:17m:51s (EST)

NH

1. Query

N

Search as: As drawn

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Reaxys ID 145893 View in Reaxys

1/5 CAS Registry Number: 5321-49-3 Chemical Name: 4-(phenethyl)piperazine; 1-phenethyl-piperazine Linear Structure Formula: C4H8N2HCH2C6H4CH3 Molecular Formula: C12H18N2 Molecular Weight: 190.288 Type of Substance: heterocyclic InChI Key: LKUAPSRIYZLAAO-UHFFFAOYSA-N Note:

N NH

Substance Label (18) Label References 15

Obreque-Balboa, Jos Esteban; Sun, Qiu; Bernhardt, Günther; König, Burkhard; Buschauer, Armin; European Journal of Medicinal Chemistry; vol. 109; (2016); p. 124 - 133, View in Reaxys

6g

Schinin, Barbara; Martorana, Andrea; Colabufo, Nicola Antonio; Contino, Marialessandra; Niso, Mauro; Perrone, Maria Grazia; De Guidi, Guido; Catalfo, Alfio; Rappazzo, Giancarlo; Zuccarello, Elisa; Prezzavento, Orazio; Amata, Emanuele; Rescifina, Antonio; Marrazzo, Agostino; RSC Advances; vol. 5; nb. 58; (2015); p. 47108 - 47113, View in Reaxys

3m

Jallapally, Anvesh; Addla, Dinesh; Yogeeswari, Perumal; Sriram, Dharmarajan; Kantevari, Srinivas; Bioorganic and Medicinal Chemistry Letters; vol. 24; nb. 23; (2014); p. 5520 - 5524, View in Reaxys

1-PEP

Montesano, Camilla; Sergi, Manuel; Moro, Mariaelena; Napoletano, Sabino; Romolo, Francesco Saverio; Carlo, Michele Del; Compagnone, Dario; Curini, Roberta; Journal of Mass Spectrometry; vol. 48; nb. 1; (2013); p. 49 - 59, View in Reaxys

8

Prezzavento; Arena; Parenti; Pasquinucci; Arico; Scoto; Grancara; Toninello; Ronsisvalle; Journal of Medicinal Chemistry; vol. 56; nb. 6; (2013); p. 2447 - 2455, View in Reaxys

14, R2=2-(phenyl)ethyl

Anandan, Sampath-Kumar; Ward, John S.; Brokx, Richard D.; Denny, Trisha; Bray, Mark R.; Patel, Dinesh V.; Xiao, Xiao-Yi; Bioorganic and Medicinal Chemistry Letters; vol. 17; nb. 21; (2007); p. 5995 - 5999, View in Reaxys

8e

Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Taylor, David A.; Australian Journal of Chemistry; vol. 60; nb. 12; (2007); p. 928 - 933, View in Reaxys

27b

Moehrle, Hans; Azodi, Katja; Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences; vol. 61; nb. 8; (2006); p. 1021 - 1034, View in Reaxys

PEP

Bohnert, Juergen A.; Kern, Winfried V.; Antimicrobial Agents and Chemotherapy; vol. 49; nb. 2; (2005); p. 849 - 852, View in Reaxys

14e

Patent; Anandan, Sampath K.; Xiao, Ziao-Yi; Patel, Dinesh V.; Ward, John S.; US2005/234033; (2005); (A1) English, View in Reaxys

7, t.3, entry 5

Kumar, Kamal; Zapf, Alexander; Michalik, Dirk; Tillack, Annegret; Heinrich, Timo; Boettcher, Henning; Arlt, Michael; Beller, Matthias; Organic Letters; vol. 6; nb. 1; (2004); p. 7 - 10, View in Reaxys

fig.3, 10

Moloney, Gerard P.; Garavelas, Agatha; Martin, Graeme R.; Maxwell, Miles; Glen, Robert C.; European Journal of Medicinal Chemistry; vol. 39; nb. 4; (2004); p. 305 - 321, View in Reaxys

9a

Kumar, Kamal; Michalik, Dirk; Castro, Ivette Garcia; Tillack, Annegret; Zapf, Alexander; Arlt, Michael; Heinrich, Timo; Boettcher, Henning; Beller, Matthias; Chemistry - A European Journal; vol. 10; nb. 3; (2004); p. 746 - 757, View in Reaxys

Starting, Table 3, (R=H)

Michalik, Dirk; Kumar, Kamal; Zapf, Alexander; Tillack, Annegret; Arlt, Michael; Heinrich, Timo; Beller, Matthias; Tetrahedron Letters; vol. 45; nb. 10; (2004); p. 2057 - 2061, View in Reaxys

6

Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Podloucka, Anna; Taylor, David A.; Australian Journal of Chemistry; vol. 56; nb. 9; (2003); p. 875 - 886, View in Reaxys

Am3

Liegeois, Jean-Francois; Eyrolles, Laurence; Ellenbroek, Bart A.; Lejeune, Christel; Carato, Pascal; Bruhwyler, Jacques; Geczy, Joseph; Damas, Jacques; Delarge, Jacques; Journal of Medicinal Chemistry; vol. 45; nb. 23; (2002); p. 5136 - 5149, View in Reaxys

IVa

Kanojia, Ramesh M.; Salata, Joseph J.; Kauffman, Jack; Bioorganic and Medicinal Chemistry Letters; vol. 10; nb. 24; (2000); p. 2819 - 2823, View in Reaxys

13e

Walczynski, Krzysztof; Guryn, Roman; Zuiderveld, Obbe P.; Timmerman, Henk; Farmaco; vol. 54; nb. 10; (1999); p. 684 - 694, View in Reaxys

Patent-Specific Data (4) Location in Patent References

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Patent; LEK PHARMACEUTICALS D.D.; WO2007/73935; (2007); (A1) English, View in Reaxys Patent; Pfizer Inc.; US6362195; (2002); (B1) English, View in Reaxys Patent; Solvay Pharmaceuticals GmbH; EP1176144; (2002); (A1) German, View in Reaxys Claim

Patent; Bayer Aktiengesellschaft; US4818748; (1989); (A1) English, View in Reaxys

Derivative (5) Comment (Derivative)

References

Maleat: F: 173-175grad

Jilek et al.; Collection of Czechoslovak Chemical Communications; vol. 40; (1975); p. 3386,3391, View in Reaxys

Dihydrochlorid: F: 263-265grad

Zikolova; Konstantinova; Farmatsiya (Sofia, Bulgaria); vol. 25; nb. 3; (1975); p. 1,5; ; (1966); Chem.Abstr.; vol. 84; nb. 59388v; (1976), View in Reaxys

Dioxalat: F: 220-221grad (Zers.)

Zikolova; Konstantinova; Farmatsiya (Sofia, Bulgaria); vol. 25; nb. 3; (1975); p. 1,5; ; (1966); Chem.Abstr.; vol. 84; nb. 59388v; (1976), View in Reaxys

Dihydrochlorid: F: 250-252.5grad (aus A., unkorr., Zers.)

Ikeda; Yakugaku Zasshi; vol. 89; (1969); p. 677,685; Chem.Abstr.; vol. 71; nb. 61339; (1969), View in Reaxys

Dihydrochlorid: F: 260-262grad (unkorr., Zers.)

Sacha; Acta Poloniae Pharmaceutica; vol. 21; (1964); p. 369,373,376, View in Reaxys

Melting Point (1) 1 of 1

Melting Point [°C]

156

Kumar, Kamal; Michalik, Dirk; Castro, Ivette Garcia; Tillack, Annegret; Zapf, Alexander; Arlt, Michael; Heinrich, Timo; Boettcher, Henning; Beller, Matthias; Chemistry - A European Journal; vol. 10; nb. 3; (2004); p. 746 757, View in Reaxys Boiling Point (14) Boiling Point [°C] Pressure (Boiling Point) [Torr]

References

110 - 111

0.5

Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Podloucka, Anna; Taylor, David A.; Australian Journal of Chemistry; vol. 56; nb. 9; (2003); p. 875 - 886, View in Reaxys

164 - 165

10

Zikolova; Konstantinova; Farmatsiya (Sofia, Bulgaria); vol. 25; nb. 3; (1975); p. 1,5; ; (1966); Chem.Abstr.; vol. 84; nb. 59388v; (1976), View in Reaxys

170 - 173

30

Jilek et al.; Collection of Czechoslovak Chemical Communications; vol. 40; (1975); p. 3386,3391, View in Reaxys

123 - 125

1

Pesson et al.; European Journal of Medicinal Chemistry; vol. 10; (1975); p. 567,570, View in Reaxys

114 - 123

3

Rylski et al.; Acta Poloniae Pharmaceutica; vol. 28; (1971); p. 267,268, View in Reaxys

94 - 96

0.2

Nardi et al.; Journal of Medicinal Chemistry; vol. 14; (1971); p. 635,637, View in Reaxys

114 - 122

3

Rylski et al.; Acta Poloniae Pharmaceutica; vol. 27; (1970); p. 357,359, View in Reaxys

108

0.03

Patent; Soc. Lab. Robert et. Carriere; FRM7644; (1970); Chem.Abstr.; vol. 76; nb. 140165; (1972), View in Reaxys

128 - 130

1.5

Ikeda; Yakugaku Zasshi; vol. 89; (1969); p. 677,685; Chem.Abstr.; vol. 71; nb. 61339; (1969), View in Reaxys

144 - 145

6

Mndzhoyan et al.; Armyanskii Khimicheskii Zhurnal; vol. 20; nb. 4; (1967); p. 289,290-295; Chem.Abstr.; vol. 68; nb. 29674n; (1968), View in Reaxys

160 - 190

10

Sacha; Acta Poloniae Pharmaceutica; vol. 21; (1964); p. 369,373,376, View in Reaxys

92 - 96

0.1

Patent; U. S. Vit. Pharm.; BE617599; (1962); Chem.Abstr.; vol. 59; nb. 646; (1963), View in Reaxys

110 - 114

0.2

Patent; Brit. Drug Houses Ltd.; GB840358; (1957), View in Reaxys

150 - 152

8

Baltzly et al.; Journal of the American Chemical Society; vol. 66; (1944); p. 263,265, View in Reaxys

Refractive Index (1)

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Refractive Index

Wavelength (Refractive Index) [nm]

Temperature (Refractive Index) [°C]

References

1.543

589

20

Sacha; Acta Poloniae Pharmaceutica; vol. 21; (1964); p. 369,373,376, View in Reaxys

Chromatographic Data (1) Chromatographic References data HPLC (High performance liquid chromatography)

Montesano, Camilla; Sergi, Manuel; Moro, Mariaelena; Napoletano, Sabino; Romolo, Francesco Saverio; Carlo, Michele Del; Compagnone, Dario; Curini, Roberta; Journal of Mass Spectrometry; vol. 48; nb. 1; (2013); p. 49 - 59, View in Reaxys

NMR Spectroscopy (8) 1 of 8

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

1H

Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]

400

Abe, Tsukasa; Morimoto, Yuma; Tano, Tetsuro; Mieda, Kaoru; Sugimoto, Hideki; Fujieda, Nobutaka; Ogura, Takashi; Itoh, Shinobu; Inorganic Chemistry; vol. 53; nb. 16; (2014); p. 8786 - 8794, View in Reaxys 2 of 8

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

13C

Solvents (NMR Spectro- CDCl3 scopy) Temperature (NMR Spectroscopy) [°C]

25

Frequency (NMR Spectroscopy) [MHz]

100

Kumar, Kamal; Michalik, Dirk; Castro, Ivette Garcia; Tillack, Annegret; Zapf, Alexander; Arlt, Michael; Heinrich, Timo; Boettcher, Henning; Beller, Matthias; Chemistry - A European Journal; vol. 10; nb. 3; (2004); p. 746 757, View in Reaxys 3 of 8

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

1H

Solvents (NMR Spectro- CDCl3 scopy) Temperature (NMR Spectroscopy) [°C]

25

Frequency (NMR Spectroscopy) [MHz]

400

Kumar, Kamal; Michalik, Dirk; Castro, Ivette Garcia; Tillack, Annegret; Zapf, Alexander; Arlt, Michael; Heinrich, Timo; Boettcher, Henning; Beller, Matthias; Chemistry - A European Journal; vol. 10; nb. 3; (2004); p. 746 757, View in Reaxys 4 of 8

Nucleus (NMR Spectroscopy)

1H

Coupling Nuclei

1H

Solvents (NMR Spectro- CDCl3 scopy) Temperature (NMR Spectroscopy) [°C]

25

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Frequency (NMR Spectroscopy) [MHz]

400

Kumar, Kamal; Michalik, Dirk; Castro, Ivette Garcia; Tillack, Annegret; Zapf, Alexander; Arlt, Michael; Heinrich, Timo; Boettcher, Henning; Beller, Matthias; Chemistry - A European Journal; vol. 10; nb. 3; (2004); p. 746 757, View in Reaxys 5 of 8

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

1H

Solvents (NMR Spectro- CDCl3 scopy) Frequency (NMR Spectroscopy) [MHz]

300

Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Podloucka, Anna; Taylor, David A.; Australian Journal of Chemistry; vol. 56; nb. 9; (2003); p. 875 - 886, View in Reaxys 6 of 8

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

13C

Solvents (NMR Spectro- CDCl3 scopy) Frequency (NMR Spectroscopy) [MHz]

75.4

Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Podloucka, Anna; Taylor, David A.; Australian Journal of Chemistry; vol. 56; nb. 9; (2003); p. 875 - 886, View in Reaxys 7 of 8

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

1H

Solvents (NMR Spectro- CDCl3 scopy) Caliendo, G.; Carlo, R. Di; Meli, R.; Perissutti, E.; Santagada, V.; et al.; European Journal of Medicinal Chemistry; vol. 28; nb. 12; (1993); p. 969 - 974, View in Reaxys 8 of 8

Description (NMR Spec- Spin-spin coupling constants troscopy) Solvents (NMR Spectro- CDCl3 scopy) Comment (NMR Spectroscopy)

1H-1H

Caliendo, G.; Carlo, R. Di; Meli, R.; Perissutti, E.; Santagada, V.; et al.; European Journal of Medicinal Chemistry; vol. 28; nb. 12; (1993); p. 969 - 974, View in Reaxys IR Spectroscopy (1) 1 of 1

Description (IR Spectroscopy)

Bands

Solvent (IR Spectroscopy)

nujol

Kumar, Kamal; Michalik, Dirk; Castro, Ivette Garcia; Tillack, Annegret; Zapf, Alexander; Arlt, Michael; Heinrich, Timo; Boettcher, Henning; Beller, Matthias; Chemistry - A European Journal; vol. 10; nb. 3; (2004); p. 746 757, View in Reaxys Mass Spectrometry (3) Description (Mass References Spectrometry) high resolution mass spectrome-

Abe, Tsukasa; Morimoto, Yuma; Tano, Tetsuro; Mieda, Kaoru; Sugimoto, Hideki; Fujieda, Nobutaka; Ogura, Takashi; Itoh, Shinobu; Inorganic Chemistry; vol. 53; nb. 16; (2014); p. 8786 - 8794, View in Reaxys

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try (HRMS); fast atom bombardment (FAB); spectrum liquid chromatog- Montesano, Camilla; Sergi, Manuel; Moro, Mariaelena; Napoletano, Sabino; Romolo, Francesco Saverraphy mass spec- io; Carlo, Michele Del; Compagnone, Dario; Curini, Roberta; Journal of Mass Spectrometry; vol. 48; nb. trometry (LCMS); 1; (2013); p. 49 - 59, View in Reaxys tandem mass spectrometry; spectrum spectrum; electron impact (EI)

Kumar, Kamal; Michalik, Dirk; Castro, Ivette Garcia; Tillack, Annegret; Zapf, Alexander; Arlt, Michael; Heinrich, Timo; Boettcher, Henning; Beller, Matthias; Chemistry - A European Journal; vol. 10; nb. 3; (2004); p. 746 - 757, View in Reaxys

Pharmacological Data (2) 1 of 2

Comment (Pharmacological Data)

Bioactivities present

Patent; Pfizer Inc.; US6362195; (2002); (B1) English, View in Reaxys; Patent; Takeda Chemical Industries, Ltd.; US6172085; (2001); (B2) English, View in Reaxys; Patent; Ciba-Geigy Corporation; US5286728; (1994); (A1) English, View in Reaxys; Patent; Ciba-Geigy Corporation; US4804661; (1989); (A1) English, View in Reaxys; Patent; Boehringer Ingelheim Ltd.; US4725597; (1988); (A1) English, View in Reaxys; Patent; Lowe III, John Adams; US2001/49379; (2001); (A1) English, View in Reaxys; Patent; Karl Thomae GmbH; US5006522; (1991); (A1) English, View in Reaxys; Patent; Lavielle; Gilbert; Muller; Olivier; Vayssettes-Courchay; Christine; Descombes; Jean-Jacques; Verbeuren; Tony; US6020336; (2000); (A1) English, View in Reaxys; Patent; Lowe III, John Adams; US2002/22642; (2002); (A1) English, View in Reaxys; Patent; LOWE III, JOHN A.; US2002/151572; (2002); (A1) English, View in Reaxys; Patent; Merck and Co., Inc.; US5215989; (1993); (A1) English, View in Reaxys; Patent; Hoffmann-La Roche Inc.; US5688798; (1997); (A1) English, View in Reaxys; Patent; Takeda Chemical Industries, Ltd.; EP232089; (1991); (B1) English, View in Reaxys; Patent; Uesaka, Noriaki; Imma, Hironori; Kashima, Hajime; Kurokawa, Masako; Nonaka, Hiromi; Kanda, Tomoyuki; Kuwana, Yoshihisa; Toki, Shinichiro; Shimada, Junichi; US2004/110826; (2004); (A1) English, View in Reaxys; Patent; Miikana Therapeutics Corporation; US2005/250784; (2005); (A1) English, View in Reaxys; Patent; LEK PHARMACEUTICALS D.D.; WO2007/73935; (2007); (A1) English, View in Reaxys; Patent; NICHOLAS PIRAMAL INDIA LIMITED; WO2008/26125; (2008); (A2) English, View in Reaxys; Patent; JANSSEN PHARMACEUTICA NV; WO2008/43775; (2008); (A1) English, View in Reaxys; Patent; Brit. Drug Houses Ltd.; GB840358; (1957), View in Reaxys; Baltzly et al.; Journal of the American Chemical Society; vol. 66; (1944); p. 263,265, View in Reaxys; Morren et al.; Bulletin des Societes Chimiques Belges; vol. 60; (1951); p. 282,288, View in Reaxys; Irikura; Masuzawa; Nishino; Kitagawa; Uchida; Ichinoseki; Ito; Journal of medicinal chemistry; vol. 11; nb. 4; (1968); p. 801 - 804, View in Reaxys; Pesson et al.; European Journal of Medicinal Chemistry; vol. 10; (1975); p. 567,570, View in Reaxys; Rylski et al.; Acta Poloniae Pharmaceutica; vol. 28; (1971); p. 267,268, View in Reaxys; Rylski et al.; Acta Poloniae Pharmaceutica; vol. 27; (1970); p. 357,359, View in Reaxys; Sacha; Acta Poloniae Pharmaceutica; vol. 21; (1964); p. 369,373,376, View in Reaxys; Ikeda; Yakugaku Zasshi; vol. 89; (1969); p. 677,685; Chem.Abstr.; vol. 71; nb. 61339; (1969), View in Reaxys; Patent; Soc. Lab. Robert et. Carriere; FRM7644; (1970); Chem.Abstr.; vol. 76; nb. 140165; (1972), View in Reaxys; Patent; U. S. Vit. Pharm.; BE617599; (1962); Chem.Abstr.; vol. 59; nb. 646; (1963), View in Reaxys; Jilek et al.; Collection of Czechoslovak Chemical Communications; vol. 40; (1975); p. 3386,3391, View in Reaxys; Nardi et al.; Journal of Medicinal Chemistry; vol. 14; (1971); p. 635,637, View in Reaxys; Zikolova; Konstantinova; Farmatsiya (Sofia, Bulgaria); vol. 25; nb. 3; (1975); p. 1,5; ; (1966); Chem.Abstr.; vol. 84; nb. 59388v; (1976), View in Reaxys; Mndzhoyan et al.; Armyanskii Khimicheskii Zhurnal; vol. 20; nb. 4; (1967); p. 289,290-295; Chem.Abstr.; vol. 68; nb. 29674n; (1968), View in Reaxys; Kurokawa, Mikio; Sato, Fuminori; Hatano, Naonobu; Honda, Yayoi; Uno, Hitoshi; Journal of Medicinal Chemistry; vol. 34; nb. 2; (1991); p. 593 - 599, View in Reaxys; Kurokawa, Mikio; Sato, Fuminori; Fujiwara, Iwao; Hatano, Naonobu; Honda, Yayoi; et al.; Journal of Medicinal Chemistry; vol. 34; nb. 3; (1991); p. 927 - 934, View in Reaxys; Valenta, Vladimir; Holubek, Jiri; Svatek, Emil; Protiva, Miroslav; Collection of Czechoslovak Chemical Communications; vol. 52; nb. 12; (1987); p. 3013 - 3023, View in Reaxys; Murti; Bhandari; Ram; Prabhakar; Saxena; Jain; Gulati; Srimal; Dhawan; Nityanand; Anand; Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry; vol. 28; nb. 11; (1989); p. 934 - 942, View in Reaxys; Saxena, Anil K.; Arunamurthy, V.; Patnaik, G. 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ssutti, E.; Santagada, V.; et al.; European Journal of Medicinal Chemistry; vol. 28; nb. 12; (1993); p. 969 - 974, View in Reaxys; Meanwell, Nicholas A.; Hewawasam, Piyasena A.; Thomas, Jeanine; Wright, J. J. Kim; Russell, John W.; et al.; Journal of Medicinal Chemistry; vol. 36; nb. 22; (1993); p. 3251 - 3264, View in Reaxys; Dauzonne; Gillardin; Lepage; Pointet; Risse; Lamotte; Demerseman; European Journal of Medicinal Chemistry; vol. 30; nb. 1; (1995); p. 53 - 59, View in Reaxys; Caliendo, G.; Carlo, R. Di; Greco, G.; Meli, R.; Novellino, E.; et al.; European Journal of Medicinal Chemistry; vol. 30; nb. 1; (1995); p. 77 - 84, View in Reaxys; Caliendo; Greco; Grieco; Novellino; Perissutti; Santagada; Barbarulo; Esposito; De Blasi; European Journal of Medicinal Chemistry; vol. 31; nb. 3; (1996); p. 207 - 213, View in Reaxys; Rowley, Michael; Collins, Ian; Broughton, Howard B.; Davey, William B.; Baker, Raymond; Emms, Frances; Marwood, Rosemarie; Patel, Shil; Patel, Smita; Ragan, C. 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Effect (Pharmacological Data)

bacterial resistance; inhibition of

Species or Test-System (Pharmacological Data)

Escherichia coli 3-AG100MKX

Method (Pharmacological Data)

cells incubated with levofloxacin in presence of title comp.; levofloxacin MIC determined by spectrofotometric assay

Further Details (Pharmacological Data)

3-AG100MKX: AcrAB-overexpressing gyrA mutant derived from AG100MKX (AG100 marA::Kmr); AcrAB: efflux pump; reference comp.: Phe-Arg-β-naphtylamide

Results

title comp. conc. to reduce levofloxacin MIC by 4-fold was > 200 μg/ml

Bohnert, Juergen A.; Kern, Winfried V.; Antimicrobial Agents and Chemotherapy; vol. 49; nb. 2; (2005); p. 849 852, View in Reaxys

Reaxys ID 3715739 View in Reaxys

2/5 CAS Registry Number: 5321-62-0 Chemical Name: 1-phenethyl-piperazine; dihydrochloride; 1Phenaethyl-piperazin; Dihydrochlorid; 1-(2-phenylethyl)piperazine dihydrochloride Linear Structure Formula: C12H18N2*2ClH Molecular Formula: C12H18N2*2ClH Molecular Weight: 263.21 Type of Substance: heterocyclic InChI Key: BSHOYJJVRWCKSJ-UHFFFAOYSA-N Note:

Cl 2 H

N NH

Melting Point (2) 1 of 2

Melting Point [°C]

280 - 282

Comment (Melting Point)

Decomp.

Patent; Brit. Drug Houses Ltd.; GB840358; (1957), View in Reaxys 2 of 2

Melting Point [°C]

252

Solvent (Melting Point)

ethanol

Baltzly et al.; Journal of the American Chemical Society; vol. 66; (1944); p. 263,265, View in Reaxys

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Reaxys ID 28264292 View in Reaxys

3/5 Chemical Name: 1-phenethylpiperazine hydrochloride Linear Structure Formula: xClH*C12H18N2 Molecular Formula: C12H18N2*(x)ClH InChI Key: BSHOYJJVRWCKSJ-UHFFFAOYSA-N Note:

-1 HCl

N NH

Reaxys ID 8026462 View in Reaxys

4/5

HO

Chemical Name: phenethylpiperazine trifluoroacetate Linear Structure Formula: C12H18N2*C2HF3O2 Molecular Formula: C2HF3O2*C12H18N2 Molecular Weight: 304.312 Type of Substance: heterocyclic InChI Key: ALOJUPNMVIWNOT-UHFFFAOYSA-N Note:

F F

N NH

F

O

Reaxys ID 28191277 View in Reaxys

5/5 Chemical Name: 1-phenethylpiperazine hydrochloride Linear Structure Formula: ClH*C12H18N2 Molecular Formula: C12H18N2*ClH Molecular Weight: 226.749 InChI Key: BSHOYJJVRWCKSJ-UHFFFAOYSA-N Note:

HCl

N NH

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