Query Query
H HO
Results
Date
1 substances in Reaxys
2017-11-08 16h:56m:24s (EST)
NH 2 H
1. Query
Search as: As drawn, No salts, No mixtures, No isotopes, No charges, No radicals
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Reaxys ID 2802895 View in Reaxys
H 2N H
1/1 CAS Registry Number: 492-39-7 Chemical Name: (1S,2S)-2-amino-1-phenylpropanol Linear Structure Formula: H2NCH(CH3)CH(OH)C6H5 Molecular Formula: C9H13NO Molecular Weight: 151.208 Type of Substance: isocyclic InChI Key: DLNKOYKMWOXYQA-IONNQARKSA-N Note:
H OH
Substance Label (16) Label References 20
Martins, Bruna S.; Moro, Angélica V.; Lüdtke, Diogo S.; Journal of Organic Chemistry; vol. 82; nb. 6; (2017); p. 3334 - 3340, View in Reaxys
1
Balachandran; Chennakesava Rao; Arun; Emi; Yamamoto; Inaguma; Okamoto; Easwaramoorthi; Perumal; RSC Advances; vol. 6; nb. 99; (2016); p. 96946 - 96962, View in Reaxys
5
Parrott II, Raleigh W.; Hitchcock, Shawn R.; Tetrahedron Asymmetry; vol. 19; nb. 1; (2008); p. 19 - 26, View in Reaxys
H
Ma, Guoyi; Bavadekar, Supriya A.; Davis, Yolande M.; Lalchandani, Shilpa G.; Nagmani, Rangaswamy; Schaneberg, Brian T.; Khan, Ikhlas A.; Feller, Dennis R.; Journal of Pharmacology and Experimental Therapeutics; vol. 322; nb. 1; (2007); p. 214 - 221, View in Reaxys
1a-(S,S)
Groeper, Jonathan A.; Hitchcock, Shawn R.; Ferrence, Gregory M.; Tetrahedron Asymmetry; vol. 17; nb. 20; (2006); p. 2884 - 2889, View in Reaxys
3b-(1S,2S), (syn)
Purkarthofer, Thomas; Gruber, Karl; Gruber-Khadjawi, Mandana; Waich, Kerstin; Skranc, Wolfgang; Mink, Daniel; Griengl, Herfried; Angewandte Chemie - International Edition; vol. 45; nb. 21; (2006); p. 3454 - 3456, View in Reaxys
16
Frelek, Jadwiga; Gorecki, Marcin; Jazwinski, Jaroslaw; Masnyk, Marek; Ruskowska, Patrycja; Szmigielski, Rafal; Tetrahedron Asymmetry; vol. 16; nb. 19; (2005); p. 3188 - 3197, View in Reaxys
11
Tanimori, Shinji; Naka, Toshihito; Kirihata, Mitsunori; Synthetic Communications; vol. 34; nb. 22; (2004); p. 4043 - 4048, View in Reaxys
from trans-4S,5S
Meririnne, Esa; Ellermaa, Satu; Kankaanpaeae, Aino; Bardy, Ali; Seppaelae, Timo; Journal of Pharmacology and Experimental Therapeutics; vol. 309; nb. 3; (2004); p. 1198 - 1205, View in Reaxys
19
Frelek, Jadwiga; Klimek, Agata; Rukowska, Patrycja; Tetrahedron Asymmetry; vol. 13; nb. 22; (2002); p. 2461 - 2469, View in Reaxys
ent-17
Nishimura, Masaaki; Minakata, Satoshi; Takahashi, Toru; Oderaotoshi, Yoji; Komatsu, Mitsuo; Journal of Organic Chemistry; vol. 67; nb. 7; (2002); p. 2101 - 2110, View in Reaxys
8
Brandes; Jacobsen; Synlett; nb. SPEC. ISS; (2001); p. 1013 - 1015, View in Reaxys
1b
Wu, Yangjie; Yun, Hongying; Wu, Yusheng; Ding, Kuiling; Zhou, Ying; Tetrahedron Asymmetry; vol. 11; nb. 17; (2000); p. 3543 - 3552, View in Reaxys
alcohol to 13
Neuville, Luc; Chastanet, Jaqueline; Zhu, Jieping; Tetrahedron Letters; vol. 40; nb. 39; (1999); p. 7087 7090, View in Reaxys
4
Grue-Sorensen; Spenser; Canadian Journal of Chemistry; vol. 67; nb. 6; (1989); p. 998 - 1009, View in Reaxys
21
Brunner, Henri; Miehling, Wolfgang; Monatshefte fuer Chemie; vol. 115; (1984); p. 1237 - 1254, View in Reaxys
Patent-Specific Data (1) Prophetic ComReferences pound prophetic product
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys
Druglikeness (1) 1 of 1
LogP
0.998
H Bond Donors
2
H Bond Acceptors
2
Rotatable Bonds
2
TPSA
46.25
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Lipinski Number
4
Veber Number
2
Highest Clinical Phase (1) Highest Clinical Phase Marketed Related Structure (1) Related Structure References Zur Konfiguration der nachstehend beschriebenen Stereoisomeren vgl. die Angaben ueber die Konfiguration von Ephedrin und Pseudoephedrin. Derivative (4) Comment (Derivative) HCl (19): C9H13NO*HCl: CD
Beilstein Handbook, View in Reaxys
References Dornhege; Snatzke; Tetrahedron; vol. 26; (1970); p. 3059,3060,3064, View in Reaxys
D-mandelate (mp: Jarowski; Hartung; Journal of Organic Chemistry; vol. 8; (1943); p. 564,566, View in Reaxys 170 degree ; <alpha>=-45.3 degree ); Further Data see Handbook (Solubility) Dg-hydrogentartrate (mp: 202 degree ); Further Data see Handbook (Preparation, Mutarotation)
Kanao; Yakugaku Zasshi; vol. 48; (1928); p. 122; Chem. Zentralbl.; vol. 100; nb. I; (1929); p. 240, View in Reaxys; Kanao; Chem. Zentralbl.; vol. 100; nb. II; (1929); p. 2553, View in Reaxys; Nagai; Kanao; Justus Liebigs Annalen der Chemie; vol. 470; (1929); p. 174; Chem. Zentralbl.; vol. 99; nb. II; (1928); p. 2553, View in Reaxys
Lg-hydrogentartrate (mp: 149-151 degree , needles); Further Data see Handbook (Mutarotation)
Gibson; Levin; Journal of the Chemical Society; (1929); p. 2757, View in Reaxys; Smith; Journal of the Chemical Society; (1928); p. 51,52, View in Reaxys
Purification (2) Purification (method) LEC, column: C20-Proline phase, 50 deg C
References Gelber, Loren R.; Karger, Barry L.; Neumeyer, John L.; Feibush, Binyamin; Journal of the American Chemical Society; vol. 106; nb. 25; (1984); p. 7729 - 7734, View in Reaxys
partition with 1.0 Prelog, Vladimir; Mutak, Stjepan; Kovacevic, Krunoslav; Helvetica Chimica Acta; vol. 66; nb. 7; (1983); p. M di(5-nonyl es2279 - 2284, View in Reaxys ter) of (R,R)-tartaric acid/(ClCH2)2 (aq. phase: 0.5 M NaPF6, 0.05 M amin*HCl), 4 deg C Melting Point (7) 1 of 7
Melting Point [°C]
70 - 72
Martins, Bruna S.; Moro, Angélica V.; Lüdtke, Diogo S.; Journal of Organic Chemistry; vol. 82; nb. 6; (2017); p. 3334 - 3340, View in Reaxys 2 of 7
Melting Point [°C]
70 - 72
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Lee, Hyeon-Kyu; Kang, Soyeong; Choi, Eun Bok; Journal of Organic Chemistry; vol. 77; nb. 12; (2012); p. 5454 5460, View in Reaxys 3 of 7
Melting Point [°C]
72 - 74
Groeper, Jonathan A.; Hitchcock, Shawn R.; Ferrence, Gregory M.; Tetrahedron Asymmetry; vol. 17; nb. 20; (2006); p. 2884 - 2889, View in Reaxys 4 of 7
Melting Point [°C]
78 - 79
McKenzie; Luis; Mitchell; Chemische Berichte; vol. 65; (1932); p. 798,803, View in Reaxys 5 of 7
Melting Point [°C]
77.5 - 78
Solvent (Melting Point)
benzene
Kanao; Chem. Zentralbl.; vol. 100; nb. I; (1929); p. 241, View in Reaxys; Nagai; Kanao; Justus Liebigs Annalen der Chemie; vol. 470; (1929); p. 174; Chem. Zentralbl.; vol. 99; nb. II; (1928); p. 2553, View in Reaxys 6 of 7
Melting Point [°C]
77
Gibson; Levin; Journal of the Chemical Society; (1929); p. 2757, View in Reaxys 7 of 7
Melting Point [°C]
77 - 78
Smith; Journal of the Chemical Society; (1928); p. 51,52, View in Reaxys Association (MCS) (2) 1 of 2
Description (Association Further physical properties of the complex (MCS)) Solvent (Association (MCS))
ethanol
Comment (Association (MCS))
ambient temperature
Partner (Association (MCS))
rhodium(II) acetate
Frelek, Jadwiga; Gorecki, Marcin; Jazwinski, Jaroslaw; Masnyk, Marek; Ruskowska, Patrycja; Szmigielski, Rafal; Tetrahedron Asymmetry; vol. 16; nb. 19; (2005); p. 3188 - 3197, View in Reaxys 2 of 2
Description (Association Further physical properties of the complex (MCS)) Solvent (Association (MCS))
dimethylsulfoxide
Partner (Association (MCS))
Mo2(OAc)4
Frelek, Jadwiga; Klimek, Agata; Rukowska, Patrycja; Tetrahedron Asymmetry; vol. 13; nb. 22; (2002); p. 2461 2469, View in Reaxys Chromatographic Data (5) Chromatographic Location data
References
HPLC (High performance liquid chromatography)
Paíga, Paula; Rodrigues, Manuela J.E.; Correia, Manuela; Amaral, Joana S.; Oliveira, M. Beatriz P.P.; Delerue-Matos, Cristina; European Journal of Pharmaceutical Sciences; vol. 99; (2017); p. 219 - 227, View in Reaxys
GC (Gas chromatography)
Robayo, Diego A. Sánchez; Mendez, William F. Garzón; Ocampo, Gonzalo Taborda; Moreano, Milton Rosero; Journal of the Brazilian Chemical Society; vol. 27; nb. 6; (2016); p. 992 - 997, View in Reaxys; Ademiluyi, Adedayo O.; Ogunsuyi, Opeyemi B.; Oboh, Ganiyu; NeuroToxicology; vol. 56; (2016); p. 107 - 117, View in Reaxys
LC (Liquid chromatography)
Jeong, Eun Sook; Kim, So-Hee; Cha, Eun-Ju; Lee, Kang Mi; Kim, Ho Jun; Lee, Sang-Won; Kwon, Oh-Seung; Lee, Jaeick; Rapid Communications in Mass Spectrometry; vol. 29; nb. 4; (2015); p. 367 - 384, View in Reaxys; Jeong, Eun Sook; Kim, SoHee; Cha, Eun-Ju; Lee, Kang Mi; Kim, Ho Jun; Lee, Sang-Won; Kwon, Oh-Seung; Lee, Jaeick; Rapid Communications in Mass Spectrometry; vol. 29; nb. 4; (2015); p. 367 - 384, View in Reaxys
HPLC (High performance liquid chromatography)
supporting information
Sehl, Torsten; Hailes, Helen C.; Ward, John M.; Menyes, Ulf; Pohl, Martina; Rother, Doerte; Green Chemistry; vol. 16; nb. 6; (2014); p. 3341 - 3348, View in Reaxys
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GC (Gas chroma- supporting infortography) mation
Sehl, Torsten; Hailes, Helen C.; Ward, John M.; Wardenga, Rainer; Von Lieres, Eric; Offermann, Heike; Westphal, Robert; Pohl, Martina; Rother, Doerte; Angewandte Chemie - International Edition; vol. 52; nb. 26; (2013); p. 6772 - 6775; Angew. Chem.; vol. 125; nb. 26; (2013); p. 6904 - 6908,5, View in Reaxys
Crystal Phase (1) Description (Crys- Temperature tal Phase) (Crystal Phase) [°C]
References
Crystal structure determination
Groeper, Jonathan A.; Hitchcock, Shawn R.; Ferrence, Gregory M.; Tetrahedron Asymmetry; vol. 17; nb. 20; (2006); p. 2884 - 2889, View in Reaxys
-100.15
Crystal Property Description (3) Colour & Other References Properties white
Martins, Bruna S.; Moro, Angélica V.; Lüdtke, Diogo S.; Journal of Organic Chemistry; vol. 82; nb. 6; (2017); p. 3334 - 3340, View in Reaxys
white
Lee, Hyeon-Kyu; Kang, Soyeong; Choi, Eun Bok; Journal of Organic Chemistry; vol. 77; nb. 12; (2012); p. 5454 - 5460, View in Reaxys
Prismen oder Tafeln
Kanao; Chem. Zentralbl.; vol. 100; nb. I; (1929); p. 241, View in Reaxys; Nagai; Kanao; Justus Liebigs Annalen der Chemie; vol. 470; (1929); p. 174; Chem. Zentralbl.; vol. 99; nb. II; (1928); p. 2553, View in Reaxys
Crystal System (1) Crystal System References monoclinic
Groeper, Jonathan A.; Hitchcock, Shawn R.; Ferrence, Gregory M.; Tetrahedron Asymmetry; vol. 17; nb. 20; (2006); p. 2884 - 2889, View in Reaxys
Further Information (1) Description (Fur- References ther Information) Further information
Dornhege; Snatzke; Tetrahedron; vol. 26; (1970); p. 3059,3060,3064, View in Reaxys
Mutarotation (6) 1 of 6
Type (Mutarotation)
[M]
Comment (Mutarotation) Loesungen in Aceton zeigen Mutarotation. Lesslie; Turner; Winton; Journal of the Chemical Society; (1941); p. 257, View in Reaxys 2 of 6
Type (Mutarotation)
[alpha]
Concentration (Mutarotation)
p=4.8
Solvent (Mutarotation)
ethanol
Mutarotation [deg]
33.1
Wavelength (Mutarotation) [nm]
589
Temperature (Mutarotation) [°C]
20
Nagai; Kanao; Justus Liebigs Annalen der Chemie; vol. 470; (1929); p. 104, View in Reaxys 3 of 6
Type (Mutarotation)
[alpha]
Concentration (Mutarotation)
c=0.7
Solvent (Mutarotation)
methanol
Mutarotation [deg]
37.5
Wavelength (Mutarotation) [nm]
546.1
Temperature (Mutarotation) [°C]
20
Gibson; Levin; Journal of the Chemical Society; (1929); p. 2757, View in Reaxys
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4 of 6
Type (Mutarotation)
[alpha]
Concentration (Mutarotation)
c=1.2
Solvent (Mutarotation)
H2O
Mutarotation [deg]
24.7
Wavelength (Mutarotation) [nm]
546.1
Temperature (Mutarotation) [°C]
20
Gibson; Levin; Journal of the Chemical Society; (1929); p. 2757, View in Reaxys 5 of 6
Type (Mutarotation)
[alpha]
Concentration (Mutarotation)
c=3
Solvent (Mutarotation)
methanol
Mutarotation [deg]
32.2
Wavelength (Mutarotation) [nm]
579
Temperature (Mutarotation) [°C]
20
Gibson; Levin; Journal of the Chemical Society; (1929); p. 2757, View in Reaxys; Smith; Journal of the Chemical Society; (1928); p. 51,52, View in Reaxys 6 of 6
Type (Mutarotation)
[alpha]
Concentration (Mutarotation)
c=3
Solvent (Mutarotation)
methanol
Mutarotation [deg]
37.9
Wavelength (Mutarotation) [nm]
546.1
Temperature (Mutarotation) [°C]
20
Gibson; Levin; Journal of the Chemical Society; (1929); p. 2757, View in Reaxys; Smith; Journal of the Chemical Society; (1928); p. 51,52, View in Reaxys Optical Rotatory Power (7) 1 of 7
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
0.065 g/100ml
Solvent (Optical Rotatory Power)
ethanol
Optical Rotatory Power [deg]
47.6
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
20
Martins, Bruna S.; Moro, Angélica V.; Lüdtke, Diogo S.; Journal of Organic Chemistry; vol. 82; nb. 6; (2017); p. 3334 - 3340, View in Reaxys 2 of 7
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
3.49 g/100ml
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Enantiomeric excess [%ee]
99
Solvent (Optical Rotatory Power)
ethanol
Optical Rotatory Power [deg]
31.8
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
22
Lee, Hyeon-Kyu; Kang, Soyeong; Choi, Eun Bok; Journal of Organic Chemistry; vol. 77; nb. 12; (2012); p. 5454 5460, View in Reaxys 3 of 7
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
3.49 g/100ml
Length of Path [cm]
10
Solvent (Optical Rotatory Power)
ethanol
Optical Rotatory Power [deg]
31.8
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
28
Groeper, Jonathan A.; Hitchcock, Shawn R.; Ferrence, Gregory M.; Tetrahedron Asymmetry; vol. 17; nb. 20; (2006); p. 2884 - 2889, View in Reaxys 4 of 7
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
1.0 g/100ml
Solvent (Optical Rotatory Power)
ethanol
Optical Rotatory Power [deg]
31.2
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
21
Ishida, Keishi; Matsuda, Hisashi; Okita, Yuji; Murakami, Masahiro; Tetrahedron; vol. 58; nb. 38; (2002); p. 7645 - 7652, View in Reaxys 5 of 7
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
0.5 g/100ml
Solvent (Optical Rotatory Power)
ethanol
Optical Rotatory Power [deg]
15.5
Wavelength (Optical Ro- 546 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
-15.3
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Dopke; Schwertner; Pharmazie; vol. 45; nb. 11; (1990); p. 867 - 867, View in Reaxys 6 of 7
Type (Optical Rotatory Power)
[alpha]
Optical Rotatory Power [deg]
-31
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
20
Patent; Deutsche Gold- und Silber-Scheideanstalt; CH592617; (1977); DE2304055; Chem.Abstr.; vol. 81; nb. 136526, View in Reaxys 7 of 7
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
c=0.7
Solvent (Optical Rotatory Power)
methanol
Optical Rotatory Power [deg]
38.1
Wavelength (Optical Ro- 546 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
18
McKenzie; Luis; Mitchell; Chemische Berichte; vol. 65; (1932); p. 798,803, View in Reaxys Space Group (1) Space Group 4
References Groeper, Jonathan A.; Hitchcock, Shawn R.; Ferrence, Gregory M.; Tetrahedron Asymmetry; vol. 17; nb. 20; (2006); p. 2884 - 2889, View in Reaxys
NMR Spectroscopy (19) 1 of 19
Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]
400
Location
supporting information
Martins, Bruna S.; Moro, Angélica V.; Lüdtke, Diogo S.; Journal of Organic Chemistry; vol. 82; nb. 6; (2017); p. 3334 - 3340, View in Reaxys 2 of 19
Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)
13C
Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]
100
Location
supporting information
Martins, Bruna S.; Moro, Angélica V.; Lüdtke, Diogo S.; Journal of Organic Chemistry; vol. 82; nb. 6; (2017); p. 3334 - 3340, View in Reaxys
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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3 of 19
Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]
600
Location
supporting information
Sehl, Torsten; Hailes, Helen C.; Ward, John M.; Wardenga, Rainer; Von Lieres, Eric; Offermann, Heike; Westphal, Robert; Pohl, Martina; Rother, Doerte; Angewandte Chemie - International Edition; vol. 52; nb. 26; (2013); p. 6772 - 6775; Angew. Chem.; vol. 125; nb. 26; (2013); p. 6904 - 6908,5, View in Reaxys 4 of 19
Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)
13C
Solvents (NMR Spectro- chloroform-d1 scopy) Location
supporting information
Sehl, Torsten; Hailes, Helen C.; Ward, John M.; Wardenga, Rainer; Von Lieres, Eric; Offermann, Heike; Westphal, Robert; Pohl, Martina; Rother, Doerte; Angewandte Chemie - International Edition; vol. 52; nb. 26; (2013); p. 6772 - 6775; Angew. Chem.; vol. 125; nb. 26; (2013); p. 6904 - 6908,5, View in Reaxys 5 of 19
Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]
300
Location
supporting information
Lee, Hyeon-Kyu; Kang, Soyeong; Choi, Eun Bok; Journal of Organic Chemistry; vol. 77; nb. 12; (2012); p. 5454 5460, View in Reaxys 6 of 19
Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)
13C
Solvents (NMR Spectro- chloroform-d1 scopy) Temperature (NMR Spectroscopy) [°C]
23.44
Frequency (NMR Spectroscopy) [MHz]
125
Location
supporting information
Lee, Hyeon-Kyu; Kang, Soyeong; Choi, Eun Bok; Journal of Organic Chemistry; vol. 77; nb. 12; (2012); p. 5454 5460, View in Reaxys 7 of 19
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
13C
Solvents (NMR Spectro- CDCl3 scopy)
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Frequency (NMR Spectroscopy) [MHz]
100
Groeper, Jonathan A.; Hitchcock, Shawn R.; Ferrence, Gregory M.; Tetrahedron Asymmetry; vol. 17; nb. 20; (2006); p. 2884 - 2889, View in Reaxys 8 of 19
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- CDCl3 scopy) Frequency (NMR Spectroscopy) [MHz]
400
Groeper, Jonathan A.; Hitchcock, Shawn R.; Ferrence, Gregory M.; Tetrahedron Asymmetry; vol. 17; nb. 20; (2006); p. 2884 - 2889, View in Reaxys 9 of 19
Nucleus (NMR Spectroscopy)
1H
Coupling Nuclei
1H
Solvents (NMR Spectro- CDCl3 scopy) Frequency (NMR Spectroscopy) [MHz]
400
Groeper, Jonathan A.; Hitchcock, Shawn R.; Ferrence, Gregory M.; Tetrahedron Asymmetry; vol. 17; nb. 20; (2006); p. 2884 - 2889, View in Reaxys 10 of 19
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
13C
Solvents (NMR Spectro- CDCl3 scopy) Frequency (NMR Spectroscopy) [MHz]
125
Purkarthofer, Thomas; Gruber, Karl; Gruber-Khadjawi, Mandana; Waich, Kerstin; Skranc, Wolfgang; Mink, Daniel; Griengl, Herfried; Angewandte Chemie - International Edition; vol. 45; nb. 21; (2006); p. 3454 - 3456, View in Reaxys 11 of 19
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- CDCl3 scopy) Frequency (NMR Spectroscopy) [MHz]
500
Purkarthofer, Thomas; Gruber, Karl; Gruber-Khadjawi, Mandana; Waich, Kerstin; Skranc, Wolfgang; Mink, Daniel; Griengl, Herfried; Angewandte Chemie - International Edition; vol. 45; nb. 21; (2006); p. 3454 - 3456, View in Reaxys 12 of 19
Nucleus (NMR Spectroscopy)
1H
Coupling Nuclei
1H
Solvents (NMR Spectro- CDCl3 scopy) Frequency (NMR Spectroscopy) [MHz]
500
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Purkarthofer, Thomas; Gruber, Karl; Gruber-Khadjawi, Mandana; Waich, Kerstin; Skranc, Wolfgang; Mink, Daniel; Griengl, Herfried; Angewandte Chemie - International Edition; vol. 45; nb. 21; (2006); p. 3454 - 3456, View in Reaxys 13 of 19
Nucleus (NMR Spectroscopy)
1H
Coupling Nuclei
1H
Solvents (NMR Spectro- dimethylsulfoxide-d6 scopy) Temperature (NMR Spectroscopy) [°C]
26.85
Frequency (NMR Spectroscopy) [MHz]
600
Ishida, Keishi; Matsuda, Hisashi; Okita, Yuji; Murakami, Masahiro; Tetrahedron; vol. 58; nb. 38; (2002); p. 7645 - 7652, View in Reaxys 14 of 19
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- dimethylsulfoxide-d6 scopy) Temperature (NMR Spectroscopy) [°C]
26.85
Frequency (NMR Spectroscopy) [MHz]
600
Ishida, Keishi; Matsuda, Hisashi; Okita, Yuji; Murakami, Masahiro; Tetrahedron; vol. 58; nb. 38; (2002); p. 7645 - 7652, View in Reaxys 15 of 19
Description (NMR Spec- Spectrum troscopy) Nucleus (NMR Spectroscopy)
13C
Solvents (NMR Spectro- D2O scopy) Grue-Sorensen; Spenser; Journal of the American Chemical Society; vol. 115; nb. 5; (1993); p. 2052 - 2054, View in Reaxys 16 of 19
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
1H
Jackson, W. Roy; Jacobs, Howard A.; Jayatilake, Gamini S.; Matthews, Barry R.; Watson, Keith G.; Australian Journal of Chemistry; vol. 43; nb. 12; (1990); p. 2045 - 2062, View in Reaxys 17 of 19
Description (NMR Spec- Spin-spin coupling constants troscopy) Comment (NMR Spectroscopy)
1H-1H
Jackson, W. Roy; Jacobs, Howard A.; Jayatilake, Gamini S.; Matthews, Barry R.; Watson, Keith G.; Australian Journal of Chemistry; vol. 43; nb. 12; (1990); p. 2045 - 2062, View in Reaxys 18 of 19
Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- CDCl3 scopy) Lamant; Guignard; Helvetica Chimica Acta; vol. 70; nb. 5; (1987); p. 1279 - 1285, View in Reaxys
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19 of 19
Description (NMR Spec- Spin-spin coupling constants troscopy) Solvents (NMR Spectro- CDCl3 scopy) Comment (NMR Spectroscopy)
1H-1H
Lamant; Guignard; Helvetica Chimica Acta; vol. 70; nb. 5; (1987); p. 1279 - 1285, View in Reaxys IR Spectroscopy (3) 1 of 3
Description (IR Spectroscopy)
ATR (attenuated total reflectance); Bands
Martins, Bruna S.; Moro, Angélica V.; Lüdtke, Diogo S.; Journal of Organic Chemistry; vol. 82; nb. 6; (2017); p. 3334 - 3340, View in Reaxys 2 of 3
Description (IR Spectroscopy)
Bands
Solvent (IR Spectroscopy)
nujol
Groeper, Jonathan A.; Hitchcock, Shawn R.; Ferrence, Gregory M.; Tetrahedron Asymmetry; vol. 17; nb. 20; (2006); p. 2884 - 2889, View in Reaxys 3 of 3
Description (IR Spectroscopy)
Bands
Solvent (IR Spectroscopy)
CCl4
Comment (IR Spectroscopy)
3500 - 1550 cm**(-1)
Lamant; Guignard; Helvetica Chimica Acta; vol. 70; nb. 5; (1987); p. 1279 - 1285, View in Reaxys Mass Spectrometry (6) Description (Mass Comment (Mass Spectrometry) Spectrometry)
References
electrospray ionisation (ESI); spectrum
Jeong, Eun Sook; Kim, So-Hee; Cha, Eun-Ju; Lee, Kang Mi; Kim, Ho Jun; Lee, Sang-Won; Kwon, Oh-Seung; Lee, Jaeick; Rapid Communications in Mass Spectrometry; vol. 29; nb. 4; (2015); p. 367 - 384, View in Reaxys; Paíga, Paula; Rodrigues, Manuela J.E.; Correia, Manuela; Amaral, Joana S.; Oliveira, M. Beatriz P.P.; Delerue-Matos, Cristina; European Journal of Pharmaceutical Sciences; vol. 99; (2017); p. 219 227, View in Reaxys
high resolution mass spectrometry (HRMS); electrospray ionisation (ESI); timeof-flight mass spectra (TOFMS); spectrum
Martins, Bruna S.; Moro, Angélica V.; Lüdtke, Diogo S.; Journal of Organic Chemistry; vol. 82; nb. 6; (2017); p. 3334 - 3340, View in Reaxys
liquid chromatography mass spectrometry (LCMS); electrospray ionisation (ESI); spectrum
Jeong, Eun Sook; Kim, So-Hee; Cha, Eun-Ju; Lee, Kang Mi; Kim, Ho Jun; Lee, Sang-Won; Kwon, Oh-Seung; Lee, Jaeick; Rapid Communications in Mass Spectrometry; vol. 29; nb. 4; (2015); p. 367 - 384, View in Reaxys
HRMS (High resolution mass spectrometry); EI (Electron impact); Spectrum
Lee, Hyeon-Kyu; Kang, Soyeong; Choi, Eun Bok; Journal of Organic Chemistry; vol. 77; nb. 12; (2012); p. 5454 - 5460, View in Reaxys
LCMS (Liquid chromatography mass spectrometry); ESI (Electrospray ionisation);
mol peak
Thoerngren, John-Olof; Oestervall, Fredrik; Garle, Mats; Journal of Mass Spectrometry; vol. 43; nb. 7; (2008); p. 980 - 992, View in Reaxys
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Tandem mass spectrometry; Spectrum spectrum Use (5) Use Pattern
Lamant; Guignard; Helvetica Chimica Acta; vol. 70; nb. 5; (1987); p. 1279 - 1285, View in Reaxys References
pharmaceutical dosage forms with impeded extractability
Patent; BASF AKTIENGESELLSCHAFT; US2006/62847; (2006); (A1) English, View in Reaxys
sympathomimetic
Patent; BASF AKTIENGESELLSCHAFT; US2006/62847; (2006); (A1) English, View in Reaxys
α-adrenoreceptor antagonist
Patent; DOV PHARMACEUTICAL, INC.; WO2006/102029; (2006); (A2) English, View in Reaxys
anti-incontinence agent
Patent; DOV PHARMACEUTICAL, INC.; WO2006/102029; (2006); (A2) English, View in Reaxys
Additional therapeutical agent in pharmaceutical compositions
Patent; MERCK PATENT GMBH; WO2004/54970; (2004); (A1) German, View in Reaxys
Isolation from Natural Product (15) Isolation from References Natural Product leaves of Khat Atlabachew, Minaleshewa; Combrinck, Sandra; Viljoen, Alvaro M.; Hamman, Josias H.; Gouws, Chris(Catha edulis na; Journal of Ethnopharmacology; vol. 194; (2016); p. 307 - 315, View in Reaxys Vahl. Endl.), collected from ZegiePeninsula(N11° 43′, E 37° 20′), Bahirdar,Ethiopia dried leaves of Atlabachew, Minaleshewa; Chandravanshi, Bhagwan Singh; Redi-Abshiro, Mesfin; Torto, Nelson; ChiCatha edulis gome, Samuel; Pule, Bellah Oreeditse; Bulletin of the Chemical Society of Ethiopia; vol. 27; nb. 3; (2013); Forsk (Khat); col- p. 347 - 358, View in Reaxys lected from Zenzelima, the Bahir Dar area, Ethiopia twigs and fresh Atlabachew, Minaleshewa; Chandravanshi, Bhagwan Singh; Redi-Abshiro, Mesfin; Torto, Nelson; Chitender leaves of gome, Samuel; Pule, Bellah Oreeditse; Bulletin of the Chemical Society of Ethiopia; vol. 27; nb. 3; (2013); Catha edulis p. 347 - 358, View in Reaxys Forsk (Khat); collected from Sebeta, Ethiopia Ephedra gerardiana sikkimensis
Grue-Sorensen; Spenser; Canadian Journal of Chemistry; vol. 67; nb. 6; (1989); p. 998 - 1009, View in Reaxys
Aus Catha edulis
Ruecker et al.; Planta Medica; vol. 24; (1973); p. 61,62, View in Reaxys
ueber die Stammpflanze dieser Droge, auf die sich auch die ersten Angaben ueber das Vorkommen von Ephedrin beziehen
Kanao; Chemische Berichte; vol. 63; (1930); p. 97, View in Reaxys
besteht eine gewisse Unsicherheit
Wehmer,C.; Die Pflanzenstoffe, 2.Aufl.Bd.I <Jena 1929>,S.58,59, View in Reaxys; Hagers; Handbuch der pharmazeutischen Praxis <Berlin 1925>,S.1205, View in Reaxys; Chen; Schmidt; Medicine; vol. 9; (1930); p. 8, View in Reaxys; Merck,E.; E. Merck's Jahresberichte; vol. 30; (1916); p. 49, View in Reaxys
nach einer neue- Gilg; Schuerhoff; Archiv der Pharmazie (Weinheim, Germany); (1930); p. 233,236,239, View in Reaxys ren Untersuchung
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besteht Ma Chen; Journal of the American Pharmaceutical Association (1912-1977); vol. 14; (1925); p. 190, Huang aus den View in Reaxys; Gilg; Schuerhoff; Archiv der Pharmazie (Weinheim, Germany); (1930); p. 233,236,239, jungen Stengeltei- View in Reaxys len von Ephedra sinica Stapf. oder (in der Literatur faelschlich als E.equisetina Bunge bezeichneter) E.shennungiana Tang n. sp. und ist gelegentlich mit anderen Ephedra-Arten verfaelscht. Morphologische Unterscheidung einiger EphedraArten
Chen; Journal of the American Pharmaceutical Association (1912-1977); vol. 14; (1925); p. 190, View in Reaxys; Gilg; Schuerhoff; Archiv der Pharmazie (Weinheim, Germany); (1930); p. 233,236,239, View in Reaxys
ist als (+)-Norpseudoephedrin erkannt worden
Wolfes; Archiv der Pharmazie (Weinheim, Germany); (1930); p. 82, View in Reaxys
Isolierung aus Blaettern von Catha edulis
Wolfes; Archiv der Pharmazie (Weinheim, Germany); (1930); p. 82, View in Reaxys
In der chinesischen Droge Ma Huang
Nagai; Kanao; Yakugaku Zasshi; vol. 48; (1928); p. 101; Chem. Zentralbl.; vol. 99; nb. II; (1928); p. 2553, View in Reaxys; Smith; Journal of the Chemical Society; (1928); p. 51,52, View in Reaxys
Isolierung aus Rueckstaenden der EphedrinFabrikation
Nagai; Kanao; Yakugaku Zasshi; vol. 48; (1928); p. 101; Chem. Zentralbl.; vol. 99; nb. II; (1928); p. 2553, View in Reaxys; Smith; Journal of the Chemical Society; (1928); p. 51,52, View in Reaxys
Das aus den Blaettern von Catha edulis Forsk. (arabisch Kat) isolierte Katin (Cathin)
Stockman; Pharmaceutical Journal; vol. <4>35; p. 676; Chem. Zentralbl.; vol. 84; nb. I; (1913); p. 178, View in Reaxys; Chevalier; Bulletin des Sciences Pharmacologiques; vol. 18; p. 270; Chem. Zentralbl.; vol. 83; nb. I; (1912); p. 371, View in Reaxys; Beitter; Archiv der Pharmazie (Weinheim, Germany); vol. 239; (1901); p. 24, View in Reaxys
Medchem (148) 1 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
In Vitro (others)
Bioassay Details
Effect : |agonist Target : human embryonic kidney 293 cells expressing human α1A-ARBioassay : control: untreated cells; reference compound: L-phenylephrine (EC50: 2.01 μM); AR: adrenergic receptors; TRE-LUC: phorbol ester-response element-luciferase gene cells transfected with TRE-LUC; treated with title comp. (20 h); cells lysed; luciferase activity detd. using TopCount Microplate Scintillation and luminescence counter; data normalized relative to luciferase changes of 3E-4 M L-phenylephrine
Substance RN
2802895View in Reaxys
Substance Name
1466720
Substance Dose
0.300000 mM
Qualitative Results
title comp. at 0.3 mM had little effect on human α1A-AR; title comp. gave response that was <12% of L-phenylephrine maximum; fig.
Measurement Parameter
Qualitative
Ma, Guoyi; Bavadekar, Supriya A.; Davis, Yolande M.; Lalchandani, Shilpa G.; Nagmani, Rangaswamy; Schaneberg, Brian T.; Khan, Ikhlas A.; Feller, Dennis R.; Journal of Pharmacology and Experimental Therapeutics; vol. 322; nb. 1; (2007); p. 214 - 221, View in Reaxys 2 of 148
Bioassay Category
In Vitro (Efficacy)
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Bioassay Name
In Vitro (others)
Bioassay Details
Effect : |agonist Target : Chinese hamster ovary cells expressing human α2A-ARBioassay : reference compound: medetomidine (EC50: 79.8 nM); AR: adrenergic receptors; CRE-LUC: cAMP-response element-luciferase; data normalized relative to luciferase changes of 3E-6 M forskolin cells transfected with 6 CRE-LUC; treated with title comp. and forskolin for 4 h; cells lysed; luciferase activity measured using Luclite assay kit; conc.-dependent reversal of forskolin-induced luciferase changes detd. to assess agonist activity
Substance RN
2802895View in Reaxys
Substance Name
1466720
Substance Dose
300 µM
Measurement Parameter
Qualitative
Qualitative value
NA
Measurement pX
1
Ma, Guoyi; Bavadekar, Supriya A.; Davis, Yolande M.; Lalchandani, Shilpa G.; Nagmani, Rangaswamy; Schaneberg, Brian T.; Khan, Ikhlas A.; Feller, Dennis R.; Journal of Pharmacology and Experimental Therapeutics; vol. 322; nb. 1; (2007); p. 214 - 221, View in Reaxys 3 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
In Vitro (others)
Bioassay Details
Effect : |agonist Target : Chinese hamster ovary cells expressing human α2C-ARBioassay : reference compound: medetomidine (EC50: 78.3 nM); AR: adrenergic receptors; CRE-LUC: cAMP-response element-luciferase; data normalized relative to luciferase changes of 3E-6 M forskolin cells transfected with 6 CRE-LUC; treated with title comp. and forskolin for 4 h; cells lysed; luciferase activity measured using Luclite assay kit; conc.-dependent reversal of forskolin-induced luciferase changes detd. to assess agonist activity
Substance RN
2802895View in Reaxys
Substance Name
1466720
Substance Dose
300 µM
Measurement Parameter
Qualitative
Qualitative value
NA
Measurement pX
1
Ma, Guoyi; Bavadekar, Supriya A.; Davis, Yolande M.; Lalchandani, Shilpa G.; Nagmani, Rangaswamy; Schaneberg, Brian T.; Khan, Ikhlas A.; Feller, Dennis R.; Journal of Pharmacology and Experimental Therapeutics; vol. 322; nb. 1; (2007); p. 214 - 221, View in Reaxys 4 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
In Vitro (others)
Bioassay Details
Effect : |antagonist Target : human embryonic kidney 293 cells expressing human α1AARBioassay : control: untreated cells; AR: adrenergic receptors; TRE-LUC: phorbol esterresponse element-luciferase gene; TMS: TopCount Microplate Scintillation and luminescence counter cells transfected with TRE-LUC; title comp. added to cells; 15 min later, Lphenylephrine added; incubated for 20 h; cells lysed; luciferase activity detd. using TMS; data normalized relative to luciferase changes of 3E-4 M L-phenylephrine
Substance RN
2802895View in Reaxys
Substance Name
1466720
Measurement Parameter
Kb
Unit
µM
Quantitative value
16.9
Measurement pX
4.77
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Ma, Guoyi; Bavadekar, Supriya A.; Davis, Yolande M.; Lalchandani, Shilpa G.; Nagmani, Rangaswamy; Schaneberg, Brian T.; Khan, Ikhlas A.; Feller, Dennis R.; Journal of Pharmacology and Experimental Therapeutics; vol. 322; nb. 1; (2007); p. 214 - 221, View in Reaxys 5 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
In Vitro (others)
Bioassay Details
Effect : |receptor; binding activity Target : Chinese hamster ovary cells expressing human α2A-ARBioassay : AR: adrenergic receptors; reference compound: medetomidine (pKi: 6.15) cells incubated with title comp. and <3H>rauwolscine for 1 h at 37 deg C in Tris-EDTA buffer; filtered; radioactivity on filter discs measured using liquid scintillation analyzer; nonspecific binding detd. in presence of 10 μM phentolamine; Ki detd.
Substance RN
2802895View in Reaxys
Substance Name
1466720
Substance Dose
1.00000E-11 M
Measurement Parameter
pKi
Quantitative value
4.32
Measurement pX
4.32
Ma, Guoyi; Bavadekar, Supriya A.; Davis, Yolande M.; Lalchandani, Shilpa G.; Nagmani, Rangaswamy; Schaneberg, Brian T.; Khan, Ikhlas A.; Feller, Dennis R.; Journal of Pharmacology and Experimental Therapeutics; vol. 322; nb. 1; (2007); p. 214 - 221, View in Reaxys 6 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
In Vitro (others)
Bioassay Details
Effect : |receptor; binding activity Target : Chinese hamster ovary cells expressing human α2C-ARBioassay : AR: adrenergic receptors; reference compound: medetomidine (pKi: 7.65) cells incubated with title comp. and <3H>rauwolscine for 1 h at 37 deg C in Tris-EDTA buffer; filtered; radioactivity on filter discs measured using liquid scintillation analyzer; nonspecific binding detd. in presence of 10 μM phentolamine; Ki detd.
Substance RN
2802895View in Reaxys
Substance Name
1466720
Substance Dose
1.00000E-11 M
Measurement Parameter
pKi
Quantitative value
4.5
Measurement pX
4.5
Ma, Guoyi; Bavadekar, Supriya A.; Davis, Yolande M.; Lalchandani, Shilpa G.; Nagmani, Rangaswamy; Schaneberg, Brian T.; Khan, Ikhlas A.; Feller, Dennis R.; Journal of Pharmacology and Experimental Therapeutics; vol. 322; nb. 1; (2007); p. 214 - 221, View in Reaxys 7 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
In Vitro (others)
Bioassay Details
Effect : |receptor; binding activity Target : human embryonic kidney 293 cells expressing human α1A-ARBioassay : AR: adrenergic receptors; reference compounds: L-phenylephrine (pKi: 6.32) and oxymetazoline (pKi: 8.11) cells incubated with title comp. and <3H>prazosin for 1 h at 37 deg C in Tris-EDTA buffer; filtered; radioactivity on filter discs measured using liquid scintillation analyzer; nonspecific binding determined in presence of 10 μM phentolamine; Ki detd.
Substance RN
2802895View in Reaxys
Substance Name
1466720
Substance Dose
1.00000E-11 M
Measurement Parameter
pKi
Quantitative value
4.57
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Measurement pX
4.57
Ma, Guoyi; Bavadekar, Supriya A.; Davis, Yolande M.; Lalchandani, Shilpa G.; Nagmani, Rangaswamy; Schaneberg, Brian T.; Khan, Ikhlas A.; Feller, Dennis R.; Journal of Pharmacology and Experimental Therapeutics; vol. 322; nb. 1; (2007); p. 214 - 221, View in Reaxys 8 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
In Vitro (others)
Bioassay Details
Effect : |antagonist Target : Chinese hamster ovary cells expressing human α2A-ARBioassay : control: untreated cells; AR: adrenergic receptors; data normalized relative to luciferase changes of 3E-6 M forskolin; IC50: effective conc. of title comp. that reversed the inhibitory effect of medetomidine on maximum cAMP response of forskolin cells transfected with cAMP-response element-luciferase; title comp. added to cells; medetomidine added; 15 min later, forskolin added and incubated for 4 h; cells lysed; luciferase activity detd. using Luclite assay kit
Substance RN
2802895View in Reaxys
Substance Name
1466720
Substance Dose
1 µM
Measurement Parameter
IC50
Unit
µM
Quantitative value
7.9
Measurement pX
5.1
Ma, Guoyi; Bavadekar, Supriya A.; Davis, Yolande M.; Lalchandani, Shilpa G.; Nagmani, Rangaswamy; Schaneberg, Brian T.; Khan, Ikhlas A.; Feller, Dennis R.; Journal of Pharmacology and Experimental Therapeutics; vol. 322; nb. 1; (2007); p. 214 - 221, View in Reaxys 9 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
In Vitro (others)
Bioassay Details
Effect : |antagonist Target : Chinese hamster ovary cells expressing human α2C-ARBioassay : control: untreated cells; AR: adrenergic receptors; data normalized relative to luciferase changes of 3E-6 M forskolin; IC50: effective conc. of title comp. that reversed the inhibitory effect of medetomidine on maximum cAMP response of forskolin cells transfected with cAMP-response element-luciferase; title comp. added to cells; medetomidine added; 15 min later, forskolin added and incubated for 4 h; cells lysed; luciferase activity detd. using Luclite assay kit
Substance RN
2802895View in Reaxys
Substance Name
1466720
Substance Dose
1 µM
Measurement Parameter
IC50
Unit
µM
Quantitative value
17.4
Measurement pX
4.76
Ma, Guoyi; Bavadekar, Supriya A.; Davis, Yolande M.; Lalchandani, Shilpa G.; Nagmani, Rangaswamy; Schaneberg, Brian T.; Khan, Ikhlas A.; Feller, Dennis R.; Journal of Pharmacology and Experimental Therapeutics; vol. 322; nb. 1; (2007); p. 214 - 221, View in Reaxys 10 of 148
Target Name
Solute carrier family 22 member 5 [human]
Target Synonyms
high-affinity sodium-dependent carnitine cotransporter; octn2; organic cation/carnitine transporter 2; slc22a5; solute carrier family 22 member 5
Target Uniprot ID
o76082
Target, Subunit, Species Solute carrier family 22 member 5 [human] Target Mutant/Chimera Details
Solute carrier family 22 member 5 [human]:Wild
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11 of 148
Target Species (Bioactivity)
human
Target Transfection
Non Transfected
Substance Action on Target
Inhibitor
Bioassay Category
Metabolism/Transport
Bioassay Name
Flux uptake
Cells/Cell Lines
BeWo
Substance RN
2802895View in Reaxys
Substance Name
(+)-Nor-Epi-Ephedrine
Measurement Parameter
IC50
Unit
mM
Quantitative value
9.2
Deviation
3.90000
Measurement pX
2.04
Concomitants: Compound RN
5357404
Concomitants: Compound name
[3H]-L-Carnitine Hydrochloride
Concomitants: Compound role
SUB
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
In Vitro (others)
Substance RN
2802895View in Reaxys
Substance Name
1466720
Qualitative Results
has a weak dopamine release effect on rat striatal tissue in vitro
Measurement Parameter
Qualitative
Kalix; Geisshusler; Brenneisen; Journal of Pharmacy and Pharmacology; vol. 39; nb. 2; (1987); p. 135 - 137, View in Reaxys 12 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
In Vitro (others)
Substance RN
2802895View in Reaxys
Substance Name
1466720
Qualitative Results
effect on cardiovascular system of anesthetized rats
Measurement Parameter
Qualitative
Moya-Huff; Kiritsy; Maher; Journal of Pharmaceutical Sciences; vol. 76; nb. 2; (1987); p. 114 - 116, View in Reaxys 13 of 148
Target Name
Alpha 1 adrenergic receptor [dog]
Target Synonyms
alpha 1 adrenergic receptor
Target, Subunit, Species Alpha 1 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 1 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Target Transfection
Non Transfected
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
18/69
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Bioassay Category
In Vitro (Efficacy)
Bioassay Name
Binding
Biological Species/NCBI mongrel dog ID Organs/Tissues
lung
Cell Fraction
Membrane
Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Measurement Parameter
Ki
Unit
µM
Quantitative value
138
Measurement pX
3.86
Concomitants: Compound RN
272944; 8728926
Concomitants: Compound name
Phentolamine; [3H]-Prazosin
Concomitants: Compound role
NSB; RAD
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 14 of 148
Target Name
Alpha 1 adrenergic receptor [dog]
Target Synonyms
alpha 1 adrenergic receptor
Target, Subunit, Species Alpha 1 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 1 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Target Transfection
Non Transfected
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
Binding
Biological Species/NCBI mongrel dog ID Organs/Tissues
lung
Cell Fraction
Membrane
Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Measurement Parameter
IC50
Unit
µM
Quantitative value
351
Measurement pX
3.45
Concomitants: Compound RN
272944; 8728926
Concomitants: Compound name
Phentolamine; [3H]-Prazosin
Concomitants: Compound role
NSB; RAD
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
19/69
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Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 15 of 148
Target Name
Alpha 2 adrenergic receptor [dog]
Target Synonyms
alpha 2 adrenergic receptor
Target, Subunit, Species Alpha 2 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Target Transfection
Non Transfected
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
Binding
Biological Species/NCBI mongrel dog ID Organs/Tissues
frontal cortex
Cell Fraction
Membrane
Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Measurement Parameter
Ki
Unit
µM
Quantitative value
4
Measurement pX
5.4
Concomitants: Compound RN
272944; 5963165
Concomitants: Compound name
Phentolamine; [125I]-Clonidine
Concomitants: Compound role
NSB; RAD
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 16 of 148
Target Name
Alpha 2 adrenergic receptor [dog]
Target Synonyms
alpha 2 adrenergic receptor
Target, Subunit, Species Alpha 2 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Target Transfection
Non Transfected
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
Binding
Biological Species/NCBI mongrel dog ID Organs/Tissues
frontal cortex
Cell Fraction
Membrane
Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Measurement Parameter
IC50
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Unit
µM
Quantitative value
5
Measurement pX
5.3
Concomitants: Compound RN
272944; 5963165
Concomitants: Compound name
Phentolamine; [125I]-Clonidine
Concomitants: Compound role
NSB; RAD
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 17 of 148
Target Name
Beta-2 adrenergic receptor [dog]
Target Synonyms
adrb2; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor
Target Uniprot ID
p54833
Target, Subunit, Species Beta-2 adrenergic receptor [dog] Target Mutant/Chimera Details
Beta-2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Target Transfection
Non Transfected
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
Binding
Biological Species/NCBI mongrel dog ID Organs/Tissues
lung
Cell Fraction
Membrane
Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Measurement Parameter
Ki
Unit
µM
Quantitative value
87
Measurement pX
4.06
Concomitants: Compound RN
987417; 424938
Concomitants: Compound name
Propranolol; [125I]-Cyanopindolol
Concomitants: Compound role
NSB; RAD
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 18 of 148
Target Name
Beta-2 adrenergic receptor [dog]
Target Synonyms
adrb2; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor
Target Uniprot ID
p54833
Target, Subunit, Species Beta-2 adrenergic receptor [dog] Target Mutant/Chimera Details
Beta-2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
21/69
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Target Transfection
Non Transfected
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
Binding
Biological Species/NCBI mongrel dog ID Organs/Tissues
lung
Cell Fraction
Membrane
Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Measurement Parameter
IC50
Unit
µM
Quantitative value
325
Measurement pX
3.49
Concomitants: Compound RN
987417; 424938
Concomitants: Compound name
Propranolol; [125I]-Cyanopindolol
Concomitants: Compound role
NSB; RAD
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 19 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Intraocular pressure
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
2%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Pressure
Unit
mmHg
Quantitative value
22
Concomitants: Compound RN
3754950
Concomitants: Compound name
Proparacaine HCL
Concomitants: Compound role
ANA
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 20 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Intraocular pressure
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
22/69
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Substance Name
(+)-norpseudoephedrine
Substance Dose
1%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Pressure
Unit
mmHg
Quantitative value
24
Concomitants: Compound RN
3754950
Concomitants: Compound name
Proparacaine HCL
Concomitants: Compound role
ANA
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 21 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Intraocular pressure
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
1%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Pressure
Unit
mmHg
Quantitative value
19
Concomitants: Compound RN
3754950
Concomitants: Compound name
Proparacaine HCL
Concomitants: Compound role
ANA
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 22 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Intraocular pressure
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
2%
Substance Route of Adm.
topical administration
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
23/69
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Substance Dosing Regi- Single men Measurement Parameter
Pressure
Unit
mmHg
Quantitative value
23
Concomitants: Compound RN
3754950
Concomitants: Compound name
Proparacaine HCL
Concomitants: Compound role
ANA
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 23 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Intraocular pressure
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
1%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Pressure
Unit
mmHg
Quantitative value
18
Concomitants: Compound RN
3754950
Concomitants: Compound name
Proparacaine HCL
Concomitants: Compound role
ANA
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 24 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Intraocular pressure
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
2%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Pressure
Unit
mmHg
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
24/69
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Quantitative value
22
Concomitants: Compound RN
3754950
Concomitants: Compound name
Proparacaine HCL
Concomitants: Compound role
ANA
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 25 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Intraocular pressure
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
1%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Pressure
Unit
mmHg
Quantitative value
24
Concomitants: Compound RN
3754950
Concomitants: Compound name
Proparacaine HCL
Concomitants: Compound role
ANA
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 26 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Intraocular pressure
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
2%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Pressure
Unit
mmHg
Quantitative value
24
Concomitants: Compound RN
3754950
Concomitants: Compound name
Proparacaine HCL
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Concomitants: Compound role
ANA
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 27 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Mydriasis
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
1%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Length
Unit
mm
Measurement Object
Diameter
Quantitative value
8
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 28 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Mydriasis
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
2%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Length
Unit
mm
Measurement Object
Diameter
Quantitative value
9
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 29 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Mydriasis
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
1%
Substance Route of Adm.
topical administration
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
26/69
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Substance Dosing Regi- Single men Measurement Parameter
Length
Unit
mm
Measurement Object
Diameter
Quantitative value
8
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 30 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Mydriasis
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
2%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Length
Unit
mm
Measurement Object
Diameter
Quantitative value
9
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 31 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Mydriasis
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
1%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Length
Unit
mm
Measurement Object
Diameter
Quantitative value
8
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 32 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Mydriasis
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
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Substance Name
(+)-norpseudoephedrine
Substance Dose
2%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Length
Unit
mm
Measurement Object
Diameter
Quantitative value
9
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 33 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Mydriasis
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
1%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Length
Unit
mm
Measurement Object
Diameter
Quantitative value
8
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 34 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Mydriasis
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
2%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Length
Unit
mm
Measurement Object
Diameter
Quantitative value
9
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 35 of 148
Bioassay Category
In Vivo (Animal models)
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Bioassay Name
Spontaneous activity
Biological Species/NCBI Swiss Webster mouse ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
5 mg/kg
Substance Route of Adm.
intraperitoneal administration
Substance Dosing Regi- Single men Measurement Parameter
Time
Unit
minute
Measurement Object
Maximal stimulant effect (Horizontal activity)
Quantitative value
30
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 36 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Spontaneous activity
Biological Species/NCBI Swiss Webster mouse ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
5 mg/kg
Substance Route of Adm.
intraperitoneal administration
Substance Dosing Regi- Single men Measurement Parameter
% Max
Unit
%
Measurement Object
Depression (Horizontal activity)
Quantitative value
26
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 37 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Spontaneous activity
Biological Species/NCBI Swiss Webster mouse ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
5 mg/kg
Substance Route of Adm.
intraperitoneal administration
Substance Dosing Regi- Single men Measurement Parameter
Time
Unit
minute
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Measurement Object
Maximal depressor effect (Horizontal activity)
Quantitative value
10
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 38 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Spontaneous activity
Biological Species/NCBI Swiss Webster mouse ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
5 mg/kg
Substance Route of Adm.
intraperitoneal administration
Substance Dosing Regi- Single men Measurement Parameter
% Max
Unit
%
Measurement Object
Stimulation (Horizontal activity)
Quantitative value
123
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 39 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Spontaneous activity
Biological Species/NCBI Swiss Webster mouse ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
5 mg/kg
Substance Route of Adm.
intraperitoneal administration
Substance Dosing Regi- Single men Measurement Parameter
ED50
Unit
mg/kg
Measurement Object
Horizontal activity
Quantitative value
12.2
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 40 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Intraocular pressure
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
1%
Substance Route of Adm.
topical administration
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
30/69
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Substance Dosing Regi- Single men Measurement Parameter
Pressure
Unit
mmHg
Quantitative value
19
Deviation
2.40000
Concomitants: Compound RN
3754950
Concomitants: Compound name
Proparacaine HCL
Concomitants: Compound role
ANA
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 41 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Intraocular pressure
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
2%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Pressure
Unit
mmHg
Quantitative value
18
Deviation
2.50000
Concomitants: Compound RN
3754950
Concomitants: Compound name
Proparacaine HCL
Concomitants: Compound role
ANA
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 42 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Intraocular pressure
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
1%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Measurement Parameter
Pressure
Unit
mmHg
Quantitative value
18
Deviation
1.80000
Concomitants: Compound RN
3754950
Concomitants: Compound name
Proparacaine HCL
Concomitants: Compound role
ANA
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 43 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Intraocular pressure
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
2%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Pressure
Unit
mmHg
Quantitative value
20
Deviation
2.30000
Concomitants: Compound RN
3754950
Concomitants: Compound name
Proparacaine HCL
Concomitants: Compound role
ANA
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 44 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Intraocular pressure
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
1%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Pressure
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Unit
mmHg
Quantitative value
18
Deviation
2
Concomitants: Compound RN
3754950
Concomitants: Compound name
Proparacaine HCL
Concomitants: Compound role
ANA
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 45 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Intraocular pressure
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
2%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Pressure
Unit
mmHg
Quantitative value
20
Deviation
2
Concomitants: Compound RN
3754950
Concomitants: Compound name
Proparacaine HCL
Concomitants: Compound role
ANA
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 46 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Intraocular pressure
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
1%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Pressure
Unit
mmHg
Quantitative value
19
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Deviation
2.40000
Concomitants: Compound RN
3754950
Concomitants: Compound name
Proparacaine HCL
Concomitants: Compound role
ANA
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 47 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Intraocular pressure
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
2%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Pressure
Unit
mmHg
Quantitative value
21
Deviation
2.80000
Concomitants: Compound RN
3754950
Concomitants: Compound name
Proparacaine HCL
Concomitants: Compound role
ANA
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 48 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Mydriasis
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
1%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Length
Unit
mm
Measurement Object
Diameter
Quantitative value
8
Deviation
0.200000
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
34/69
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Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 49 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Mydriasis
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
2%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Length
Unit
mm
Measurement Object
Diameter
Quantitative value
9
Deviation
0.200000
Statistical sgnificance (p-value)
0.05
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 50 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Mydriasis
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
1%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Length
Unit
mm
Measurement Object
Diameter
Quantitative value
8
Deviation
0.200000
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 51 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Mydriasis
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
2%
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
35/69
2017-11-08 16:58:19
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Length
Unit
mm
Measurement Object
Diameter
Quantitative value
9
Deviation
0.200000
Statistical sgnificance (p-value)
0.05
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 52 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Mydriasis
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
1%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Length
Unit
mm
Measurement Object
Diameter
Quantitative value
8
Deviation
0.200000
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 53 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Mydriasis
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
2%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Length
Unit
mm
Measurement Object
Diameter
Quantitative value
9
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Deviation
0.200000
Statistical sgnificance (p-value)
0.05
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 54 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Mydriasis
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
1%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Length
Unit
mm
Measurement Object
Diameter
Quantitative value
8
Deviation
0.200000
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 55 of 148
Bioassay Category
In Vivo (Animal models)
Bioassay Name
Mydriasis
Biological Species/NCBI New Zealand White (rabbit) ID Substance RN
2802895View in Reaxys
Substance Name
(+)-norpseudoephedrine
Substance Dose
2%
Substance Route of Adm.
topical administration
Substance Dosing Regi- Single men Measurement Parameter
Length
Unit
mm
Measurement Object
Diameter
Quantitative value
9
Deviation
0.200000
Statistical sgnificance (p-value)
0.05
Patent; Booth, Anthony; Caffrey, James L.; US2003/105332; (2003); (A1) English, View in Reaxys 56 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
In Vitro (others)
Bioassay Details
Effect : |receptor; binding activity Target : Sprague-Dawley rat brain synaptosomesBioassay : caudate was used for synaptosomal preparation; DA: dopamine; positive control: methylphenidate <3H>DA uptake assay; synaptosomes incubated with <3H>DA and title
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comp. for 15 min at 25 deg C in the presence of blocker; rapid filtration; radioactivity determined in beta counter Substance RN
2802895View in Reaxys
Substance Name
1466720
Substance Dose
1 nM
Qualitative Results
title comp. did not inhibit <3H>DA uptake
Measurement Parameter
Qualitative
Rothman, Richard B.; Vu, Nga; Partilla, John S.; Roth, Bryan L.; Hufeisen, Sandra J.; Compton-Toth, Beth A.; Birkes, Jon; Young, Richard; Glennon, Richard A.; Journal of Pharmacology and Experimental Therapeutics; vol. 307; nb. 1; (2003); p. 138 - 145, View in Reaxys 57 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
In Vitro (others)
Bioassay Details
Effect : |receptor; binding activity Target : Sprague-Dawley rat brain synaptosomesBioassay : whole brain minus cerebellum and caudate was used for synaptosomal preparation; NE: norepinephrine; blocker: RTI-229; positive control: methylphenidate <3H>NE uptake assay; synaptosomes incubated with <3H>NE and title comp. for 10 min at 25 deg C in the presence of blocker; rapid filtration; radioactivity determined in beta counter
Substance RN
2802895View in Reaxys
Substance Name
1466720
Substance Dose
1 nM
Qualitative Results
title comp. did not inhibit <3H>NE uptake
Measurement Parameter
Qualitative
Rothman, Richard B.; Vu, Nga; Partilla, John S.; Roth, Bryan L.; Hufeisen, Sandra J.; Compton-Toth, Beth A.; Birkes, Jon; Young, Richard; Glennon, Richard A.; Journal of Pharmacology and Experimental Therapeutics; vol. 307; nb. 1; (2003); p. 138 - 145, View in Reaxys 58 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
In Vitro (others)
Bioassay Details
Effect : |receptor; binding activity Target : Sprague-Dawley rat brain synaptosomesBioassay : whole brain minus cerebellum and caudate was used for synaptosomal preparation; 5-HT: 5-hydroxytryptamine; blockers: nomifensine, GBR12935 <3H>5-HT uptake assay; synaptosomes incubated with <3H>5-HT and title comp. for 30 min at 25 deg C in the presence of blocker; rapid filtration; radioactivity determined in beta counter
Substance RN
2802895View in Reaxys
Substance Name
1466720
Substance Dose
1 nM
Qualitative Results
title comp. did not inhibit <3H>5-HT uptake
Measurement Parameter
Qualitative
Rothman, Richard B.; Vu, Nga; Partilla, John S.; Roth, Bryan L.; Hufeisen, Sandra J.; Compton-Toth, Beth A.; Birkes, Jon; Young, Richard; Glennon, Richard A.; Journal of Pharmacology and Experimental Therapeutics; vol. 307; nb. 1; (2003); p. 138 - 145, View in Reaxys 59 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
In Vitro (others)
Bioassay Details
Effect : |transmitter releasing Target : Sprague-Dawley rat brain synaptosomesBioassay : caudate was used for synaptosomal preparation; DA: dopamine; MPP(+): 1-methyl-4-phenylpyridinium; GBR12909: DA transporter blocker substrate reversal experiment for DA release assay; synaptosomes incubated with <3H>MPP(+) with or without GBR12909 and title comp.; rapid filtration; radioactivity determined by liquid scintillation counter
Substance RN
2802895View in Reaxys
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Substance Name
1466720
Substance Dose
140 nM
Qualitative Results
significant reversal of DA releasing effect of title comp. was observed, proving that title comp. acted as substrate at DA transporter (diagram)
Measurement Parameter
Qualitative
Rothman, Richard B.; Vu, Nga; Partilla, John S.; Roth, Bryan L.; Hufeisen, Sandra J.; Compton-Toth, Beth A.; Birkes, Jon; Young, Richard; Glennon, Richard A.; Journal of Pharmacology and Experimental Therapeutics; vol. 307; nb. 1; (2003); p. 138 - 145, View in Reaxys 60 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
In Vitro (others)
Bioassay Details
Effect : |transmitter releasing Target : Sprague-Dawley rat brain synaptosomesBioassay : whole brain minus cerebellum and caudate was used for synaptosomal preparation; 5-HT: 5-hydroxytryptamine; blockers: GBR12935, nomifensine 5-HT release assay; synaptosomes incubated with 5 nmol/l <3H>5-HT for 60 min with stirring at 25 deg C with blockers; title comp. added and further incubated for 5 min; rapid filtration; radioactivity determined by liquid scintillation counter
Substance RN
2802895View in Reaxys
Substance Name
1466720
Measurement Parameter
Qualitative
Qualitative value
NA
Measurement pX
1
Rothman, Richard B.; Vu, Nga; Partilla, John S.; Roth, Bryan L.; Hufeisen, Sandra J.; Compton-Toth, Beth A.; Birkes, Jon; Young, Richard; Glennon, Richard A.; Journal of Pharmacology and Experimental Therapeutics; vol. 307; nb. 1; (2003); p. 138 - 145, View in Reaxys 61 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
In Vitro (others)
Bioassay Details
Effect : |transmitter releasing Target : Sprague-Dawley rat brain synaptosomesBioassay : caudate was used for synaptosomal preparation; DA: dopamine; MPP(+): 1-methyl-4-phenylpyridinium; blockers: desipramine, citalopram DA release assay; synaptosomes incubated with 5 nmol/l <3H>MPP(+) for 60 min with stirring at 25 deg C with blockers; title comp. added and further incubated for 30 min; rapid filtration; radioactivity determined by liquid scintillation counter
Substance RN
2802895View in Reaxys
Substance Name
1466720
Measurement Parameter
EC50
Unit
nM
Quantitative value
68.3
Measurement pX
7.17
Rothman, Richard B.; Vu, Nga; Partilla, John S.; Roth, Bryan L.; Hufeisen, Sandra J.; Compton-Toth, Beth A.; Birkes, Jon; Young, Richard; Glennon, Richard A.; Journal of Pharmacology and Experimental Therapeutics; vol. 307; nb. 1; (2003); p. 138 - 145, View in Reaxys 62 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Name
In Vitro (others)
Bioassay Details
Effect : |transmitter releasing Target : Sprague-Dawley rat brain synaptosomesBioassay : whole brain minus cerebellum and caudate was used for synaptosomal preparation; NE: norepinephrine; MPP(+): 1-methyl-4-phenylpyridinium; blockers: GBR12935, citalopram NE release assay; synaptosomes incubated with 5 nmol/l <3H>MPP(+) for 60 min with stirring at 25 deg C with blockers; title comp. added and further incubated for 30 min; rapid filtration; radioactivity determined by liquid scintillation counter
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Substance RN
2802895View in Reaxys
Substance Name
1466720
Measurement Parameter
EC50
Unit
nM
Quantitative value
15
Measurement pX
7.82
Rothman, Richard B.; Vu, Nga; Partilla, John S.; Roth, Bryan L.; Hufeisen, Sandra J.; Compton-Toth, Beth A.; Birkes, Jon; Young, Richard; Glennon, Richard A.; Journal of Pharmacology and Experimental Therapeutics; vol. 307; nb. 1; (2003); p. 138 - 145, View in Reaxys 63 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Effective dose for stimulus generalization in (-)ephedrine-trained rats
Biological Species/NCBI Rattus norvegicus ID Substance RN
2802895View in Reaxys
Measurement Parameter
ED50
Unit
mg/kg
Qualitative value
=
Quantitative value
4.87
Young, Richard; Bondarev, Mikhail; Glennon, Richard A.; Drug and Alcohol Dependence; vol. 57; nb. 1; (1999); p. 1 - 6, View in Reaxys 64 of 148
Target Name
Amine oxidase [taurine cattle]
Target Synonyms
amine oxidase
Target, Subunit, Species Amine oxidase [taurine cattle] Target Mutant/Chimera Details
Amine oxidase [taurine cattle]:Wild
Target Species (Bioactivity)
taurine cattle
Substance Action on Target
Inhibitor
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
In vitro inhibition of beef plasma benzylamine upon incubation with compound was determined
Biological Species/NCBI taurine cattle ID
65 of 148
Substance RN
2802895View in Reaxys
Measurement Parameter
Ki
Unit
nM
Qualitative value
=
Quantitative value
10
Measurement pX
8
Bioassay Category
Toxicity/Safety Pharmacology
Bioassay Details
Lethal dose of the compound in mice following subcutaneous administration
Biological Species/NCBI Mus musculus ID Substance RN
2802895View in Reaxys
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Qualitative Results
450.0000
Measurement Parameter
LD50
Unit
mg/kg
Quantitative value
450
HOFMANN; OPITZ; SCHNELLE; Arzneimittel-Forschung; vol. 5; nb. 7; (1955); p. 367 - 370, View in Reaxys 66 of 148
Bioassay Category
Pharmacokinetic
Bioassay Details
Time taken to reach peak plasma concentration following oral administration (n=6)
Biological Species/NCBI Human ID Substance RN
2802895View in Reaxys
Qualitative Results
1.3
Measurement Parameter
Tmax
Unit
hour
Quantitative value
1.3
Frosch; Arzneimittel-Forschung; vol. 27; nb. 3; (1977); p. 665 - 668, View in Reaxys 67 of 148
Bioassay Category
Pharmacokinetic
Bioassay Details
Mean peak plasma concentration evaluated after oral administration (n=6)
Biological Species/NCBI Human ID Substance RN
2802895View in Reaxys
Qualitative Results
0.2
Measurement Parameter
Cmax
Unit
µg/mL
Quantitative value
0.2
Frosch; Arzneimittel-Forschung; vol. 27; nb. 3; (1977); p. 665 - 668, View in Reaxys 68 of 148
Bioassay Category
Toxicity/Safety Pharmacology
Bioassay Details
Dose given intraperitonially causes marked potentiation of the hepatic necrosis induced by acetaminophen in the rat
Biological Species/NCBI Rattus norvegicus ID Substance RN
2802895View in Reaxys
Measurement Parameter
TD
Unit
mg/kg
Qualitative value
=
Quantitative value
200
Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th edition; (1996); p. 1059 - 1104, View in Reaxys 69 of 148
Bioassay Category
Pharmacokinetic
Bioassay Details
Mean peak plasma concentration evaluated after oral administration (n=6)
Biological Species/NCBI Human ID Substance RN
2802895View in Reaxys
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Qualitative Results
0.2
Measurement Parameter
Cmax
Unit
µg/mL
Quantitative value
0.2
Clarke's Analysis of Drugs and Poisons, View in Reaxys 70 of 148
Bioassay Category
Metabolism/Transport
Bioassay Details
Plasma half life of the drug
Biological Species/NCBI Human ID Substance RN
2802895View in Reaxys
Qualitative Results
3
Measurement Parameter
t1/2 el
Unit
hour
Measurement Object
Half Life
Quantitative value
3
Clarke's Analysis of Drugs and Poisons, View in Reaxys 71 of 148
Bioassay Category
Pharmacokinetic
Bioassay Details
Percentage of ingested dose excreted unchanged in the urine in 6 h
Biological Species/NCBI Human ID Substance RN
2802895View in Reaxys
Qualitative Results
40
Measurement Parameter
Ue (%)
Unit
%
Quantitative value
40
Clarke's Analysis of Drugs and Poisons, View in Reaxys 72 of 148
Bioassay Category
Pharmacokinetic
Bioassay Details
Time taken to reach peak plasma concentration following oral administration (n=6)
Biological Species/NCBI Human ID Substance RN
2802895View in Reaxys
Qualitative Results
1.3
Measurement Parameter
Tmax
Unit
hour
Quantitative value
1.3
Clarke's Analysis of Drugs and Poisons, View in Reaxys 73 of 148
Target Name
Phenylethanolamine N-methyltransferase [taurine cattle]
Target Synonyms
noradrenaline n-methyltransferase; phenylethanolamine n-methyltransferase; pnmt; pnmtase
Target Uniprot ID
p10938
Target, Subunit, Species Phenylethanolamine N-methyltransferase [taurine cattle]
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Target Mutant/Chimera Details
Phenylethanolamine N-methyltransferase [taurine cattle]:Wild
Target Species (Bioactivity)
taurine cattle
Substance Action on Target
Radioligand (/ligand)
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
In vitro binding affinity of compound towards adrenal Phenylethanolamine N-Methyltransferase of bovine
Biological Species/NCBI taurine cattle ID
74 of 148
Substance RN
2802895View in Reaxys
Measurement Parameter
Ki
Unit
µM
Measurement Object
Binding affinity of compound towards adrenal Phenylethanolamine N-Methyltransferase of bovine
Qualitative value
=
Quantitative value
3700
Deviation
280
Measurement pX
2.43
Target Name
sodium-dependent dopamine transporter [rattus norvegicus]
Target Synonyms
da transporter; dat; slc6a3; sodium-dependent dopamine transporter; solute carrier family 6 member 3
Target Uniprot ID
p23977
Target, Subunit, Species sodium-dependent dopamine transporter [rattus norvegicus] Target Mutant/Chimera Details
sodium-dependent dopamine transporter [rattus norvegicus]:Wild
Target Species (Bioactivity)
Rattus norvegicus
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Effective concentration of the compound required for release of Norepinephrine transporter from rat brain synaptosomes using [3H]MPP+ as radioligand
Biological Species/NCBI Rattus norvegicus ID Substance RN
2802895View in Reaxys
Measurement Parameter
EC50
Unit
nM
Measurement Object
Release of Norepinephrine transporter from rat brain synaptosomes
Qualitative value
=
Quantitative value
15
Deviation
4.7
Measurement pX
7.82
Concomitants: Compound name
[3H]MPP
Concomitants: Compound role
RAD
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75 of 148
Target Name
Sodium-dependent dopamine transporter [Rattus norvegicus]
Target Synonyms
da transporter; dat; slc6a3; sodium-dependent dopamine transporter; solute carrier family 6 member 3
Target Uniprot ID
p23977
Target, Subunit, Species Sodium-dependent dopamine transporter [Rattus norvegicus] Target Mutant/Chimera Details
Sodium-dependent dopamine transporter [Rattus norvegicus]:Wild
Target Species (Bioactivity)
Rattus norvegicus
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Effective concentration of the compound required for release of Dopamine transporter from rat brain synaptosomes using [3H]MPP+ as radioligand
Biological Species/NCBI Rattus norvegicus ID
76 of 148
Substance RN
2802895View in Reaxys
Measurement Parameter
EC50
Unit
nM
Measurement Object
Eelease of Dopamine transporter from rat brain synaptosomes
Qualitative value
=
Quantitative value
68.3
Deviation
2.4
Measurement pX
7.17
Concomitants: Compound name
[3H]MPP
Concomitants: Compound role
RAD
Target Name
Sodium-dependent serotonin transporter [Rattus norvegicus]
Target Synonyms
5ht transporter; 5htt; slc6a4; sodium-dependent serotonin transporter; solute carrier family 6 member 4
Target Uniprot ID
p31652
Target, Subunit, Species Sodium-dependent serotonin transporter [Rattus norvegicus] Target Mutant/Chimera Details
Sodium-dependent serotonin transporter [Rattus norvegicus]:Wild
Target Species (Bioactivity)
Rattus norvegicus
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Effective concentration of the compound required for release of Serotonin transporter from rat brain synaptosomes; Inactive
Biological Species/NCBI Rattus norvegicus ID Substance RN
2802895View in Reaxys
Qualitative Results
Inactive
Measurement Parameter
EC50
Measurement Object
Effective concentration
Qualitative value
NA
Measurement pX
1
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77 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Lag time until appearance of compound in the central compartment (tlag 1) of volunteers (n = 4) upon ingestion at a dose of 32.4 +/- 8.9 mg in the form of kath leaves
Biological Species/NCBI Human ID Substance RN
2802895View in Reaxys
Measurement Parameter
Activity
Unit
hour
Measurement Object
Tlag 1
Qualitative value
=
Quantitative value
0.21
Deviation
0.22
Toennes, Stefan W.; Harder, Sebastian; Schramm, Markus; Niess, Constanze; Kauert, Gerold F.; British Journal of Clinical Pharmacology; vol. 56; nb. 1; (2003); p. 125 - 130, View in Reaxys 78 of 148
Bioassay Category
Pharmacokinetic
Bioassay Details
Time taken to reach maximum plasma concentration of compound in volunteers (n = 4) upon ingestion at a dose of 32.4 +/- 8.9 mg in the form of kath leaves
Biological Species/NCBI Human ID Substance RN
2802895View in Reaxys
Measurement Parameter
Tmax
Unit
hour
Measurement Object
Time taken to reach maximum plasma concentration
Qualitative value
=
Quantitative value
2.62
Deviation
0.77
Toennes, Stefan W.; Harder, Sebastian; Schramm, Markus; Niess, Constanze; Kauert, Gerold F.; British Journal of Clinical Pharmacology; vol. 56; nb. 1; (2003); p. 125 - 130, View in Reaxys 79 of 148
Bioassay Category
Pharmacokinetic
Bioassay Details
Mean maximum plasma concentration of compound in volunteers (n = 4) upon ingestion at a dose of 32.4 +/- 8.9 mg in the form of cath leaves
Biological Species/NCBI Human ID Substance RN
2802895View in Reaxys
Measurement Parameter
Cmax
Unit
µg/L
Measurement Object
Maximum plasma concentration
Qualitative value
=
Quantitative value
71.2
Deviation
13.9
Toennes, Stefan W.; Harder, Sebastian; Schramm, Markus; Niess, Constanze; Kauert, Gerold F.; British Journal of Clinical Pharmacology; vol. 56; nb. 1; (2003); p. 125 - 130, View in Reaxys 80 of 148
Bioassay Category
Metabolism/Transport
Bioassay Details
Apparent total body clearance of compound in volunteers (n = 4) upon ingestion at a dose of 32.4 +/- 8.9 mg in the form of kath leaves
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Biological Species/NCBI Human ID Substance RN
2802895View in Reaxys
Measurement Parameter
Cl
Unit
mL/min/kg
Measurement Object
Apparent total body clearance
Qualitative value
=
Quantitative value
791
Deviation
316
Toennes, Stefan W.; Harder, Sebastian; Schramm, Markus; Niess, Constanze; Kauert, Gerold F.; British Journal of Clinical Pharmacology; vol. 56; nb. 1; (2003); p. 125 - 130, View in Reaxys 81 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Lag time for the second segment (tlag 2) appearance of compound in the central compartment of volunteers (n = 4) upon ingestion at a dose of 32.4 +/- 8.9 mg in the form of kath leaves
Biological Species/NCBI Human ID Substance RN
2802895View in Reaxys
Measurement Parameter
Activity
Unit
hour
Measurement Object
Tlag 2
Qualitative value
=
Quantitative value
1.46
Deviation
0.59
Toennes, Stefan W.; Harder, Sebastian; Schramm, Markus; Niess, Constanze; Kauert, Gerold F.; British Journal of Clinical Pharmacology; vol. 56; nb. 1; (2003); p. 125 - 130, View in Reaxys 82 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Mean residence time of compound in volunteers (n = 4) upon ingestion at a dose of 32.4 +/- 8.9 mg in the form of kath leaves
Biological Species/NCBI Human ID Substance RN
2802895View in Reaxys
Measurement Parameter
MRT
Unit
hour
Measurement Object
Mean residence time
Qualitative value
=
Quantitative value
10.21
Deviation
2.55
Toennes, Stefan W.; Harder, Sebastian; Schramm, Markus; Niess, Constanze; Kauert, Gerold F.; British Journal of Clinical Pharmacology; vol. 56; nb. 1; (2003); p. 125 - 130, View in Reaxys 83 of 148
Bioassay Category
Pharmacokinetic
Bioassay Details
Area under the concentration-time curve of compound in volunteers (n = 4) upon ingestion at a dose of 32.4 +/- 8.9 mg in the form of kath leaves
Biological Species/NCBI Human ID
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Substance RN
2802895View in Reaxys
Measurement Parameter
AUC
Unit
µg.min/L
Measurement Object
Area under plasma concentration time curve
Qualitative value
=
Quantitative value
713
Deviation
131
Toennes, Stefan W.; Harder, Sebastian; Schramm, Markus; Niess, Constanze; Kauert, Gerold F.; British Journal of Clinical Pharmacology; vol. 56; nb. 1; (2003); p. 125 - 130, View in Reaxys 84 of 148
Bioassay Category
Metabolism/Transport
Bioassay Details
Absorbed proportion (Fabs 1) of compound in volunteers (n = 4) upon ingestion at a dose of 32.4 +/- 8.9 mg in the form of kath leaves
Biological Species/NCBI Human ID Substance RN
2802895View in Reaxys
Qualitative Results
84 +/- 6
Measurement Parameter
Absorption
Unit
%
Measurement Object
Absorbed proportion
Qualitative value
=
Quantitative value
84
Toennes, Stefan W.; Harder, Sebastian; Schramm, Markus; Niess, Constanze; Kauert, Gerold F.; British Journal of Clinical Pharmacology; vol. 56; nb. 1; (2003); p. 125 - 130, View in Reaxys 85 of 148
Bioassay Category
Metabolism/Transport
Bioassay Details
Distribution half-life of compound in volunteers (n = 4) upon ingestion at a dose of 32.4 +/8.9 mg in the form of kath leaves
Biological Species/NCBI Human ID Substance RN
2802895View in Reaxys
Measurement Parameter
t1/2
Unit
hour
Measurement Object
Half Life
Qualitative value
=
Quantitative value
0.24
Deviation
0.17
Toennes, Stefan W.; Harder, Sebastian; Schramm, Markus; Niess, Constanze; Kauert, Gerold F.; British Journal of Clinical Pharmacology; vol. 56; nb. 1; (2003); p. 125 - 130, View in Reaxys 86 of 148
Bioassay Category
Metabolism/Transport
Bioassay Details
Absorbed proportion (Fabs 2) of compound in volunteers (n = 4) upon ingestion at a dose of 32.4 +/- 8.9 mg in the form of kath leaves
Biological Species/NCBI Human ID Substance RN
2802895View in Reaxys
Qualitative Results
16 +/- 6
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Measurement Parameter
Absorption
Unit
%
Measurement Object
Absorbed proportion
Qualitative value
=
Quantitative value
16
Toennes, Stefan W.; Harder, Sebastian; Schramm, Markus; Niess, Constanze; Kauert, Gerold F.; British Journal of Clinical Pharmacology; vol. 56; nb. 1; (2003); p. 125 - 130, View in Reaxys 87 of 148
Bioassay Category
Pharmacokinetic
Bioassay Details
Maximum blood concentration of compound in volunteers (n = 4) upon ingestion at a dose of 32.4 +/- 8.9 mg in the form of kath leaves
Biological Species/NCBI Human ID Substance RN
2802895View in Reaxys
Measurement Parameter
Concentration
Unit
µg/L
Qualitative value
=
Quantitative value
87.6
Toennes, Stefan W.; Harder, Sebastian; Schramm, Markus; Niess, Constanze; Kauert, Gerold F.; British Journal of Clinical Pharmacology; vol. 56; nb. 1; (2003); p. 125 - 130, View in Reaxys 88 of 148
Bioassay Category
Metabolism/Transport
Bioassay Details
Terminal elimination half-life of compound in volunteers (n = 4) upon ingestion at a dose of 32.4 +/- 8.9 mg in the form of kath leaves
Biological Species/NCBI Human ID Substance RN
2802895View in Reaxys
Measurement Parameter
t1/2 el
Unit
hour
Measurement Object
Terminal elimination half-life
Qualitative value
=
Quantitative value
5.22
Deviation
3.36
Toennes, Stefan W.; Harder, Sebastian; Schramm, Markus; Niess, Constanze; Kauert, Gerold F.; British Journal of Clinical Pharmacology; vol. 56; nb. 1; (2003); p. 125 - 130, View in Reaxys 89 of 148
Bioassay Category
Metabolism/Transport
Bioassay Details
Apparent volume of compound in central compartment of volunteers (n = 4) upon ingestion at a dose of 32.4 +/- 8.9 mg in the form of kath leaves
Biological Species/NCBI Human ID Substance RN
2802895View in Reaxys
Unit
L/kg
Measurement Object
Apparent volume
Qualitative value
=
Quantitative value
0.74
Deviation
0.35
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Toennes, Stefan W.; Harder, Sebastian; Schramm, Markus; Niess, Constanze; Kauert, Gerold F.; British Journal of Clinical Pharmacology; vol. 56; nb. 1; (2003); p. 125 - 130, View in Reaxys 90 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Pupil diameter of rabbit eye 3 hours after treatment of compound at a dose of 2; untreated eye = 9 mm
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Activity
Unit
mM
Measurement Object
Pupil diameter
Qualitative value
=
Quantitative value
9
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 91 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Pupil diameter of rabbit eye 5 hours after treatment of compound at a dose of 2; untreated eye = 9 mm
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Activity
Unit
mM
Measurement Object
Pupil diameter
Qualitative value
=
Quantitative value
9
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 92 of 148
Target Name
Alpha 2 adrenergic receptor [dog]
Target Synonyms
alpha 2 adrenergic receptor
Target, Subunit, Species Alpha 2 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Apparent equilibrium dissociation constant (low affinity) of the compound towards dog alpha-2 adrenergic receptor using p-125iodoclonidine as radioligand incubated for 120 min at 25 degree C determined by Scatchard analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Kd
Unit
nM
Qualitative value
=
Quantitative value
0.87
Measurement pX
9.06
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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93 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Pupil diameter of rabbit eye 1 hour after treatment of compound at a dose of 2; untreated eye = 9 mm
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Activity
Unit
mM
Measurement Object
Pupil diameter
Qualitative value
=
Quantitative value
9
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 94 of 148
Target Name
Alpha 2 adrenergic receptor [dog]
Target Synonyms
alpha 2 adrenergic receptor
Target, Subunit, Species Alpha 2 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Number of high affinity binding sites of dog alpha-2 adrenergic receptor determined by Scatchard analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Qualitative
Measurement Object
BMAX1
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 95 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Intraocular pressure in rabbit eye 3 hours after treatment of compound at a dose of 2; untreated eye = 22 mmHg
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Pressure
Unit
mmHg
Measurement Object
Intraocular pressure
Qualitative value
=
Quantitative value
18
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 96 of 148
Target Name
Alpha 2 adrenergic receptor [dog]
Target Synonyms
alpha 2 adrenergic receptor
Target, Subunit, Species Alpha 2 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 2 adrenergic receptor [dog]:Wild
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Number of low affinity binding sites of dog alpha-2 adrenergic receptor determined by saturation analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Qualitative
Measurement Object
BMAX2
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 97 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Intraocular pressure in rabbit eye half hour before treatment of compound at a dose of 2; untreated eye = 17 mmHg
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Pressure
Unit
mmHg
Measurement Object
Intraocular pressure
Qualitative value
=
Quantitative value
15
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 98 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Pupil diameter of rabbit eye half hour before treatment of compound at a dose of 1; untreated eye = 5 mm
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Activity
Unit
mM
Measurement Object
Pupil diameter
Qualitative value
=
Quantitative value
5
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 99 of 148
Target Name
Alpha 2 adrenergic receptor [dog]
Target Synonyms
alpha 2 adrenergic receptor
Target, Subunit, Species Alpha 2 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Number of high affinity binding sites of dog alpha-2 adrenergic receptor determined by saturation analysis
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Substance RN
2802895View in Reaxys
Measurement Parameter
Qualitative
Measurement Object
BMAX1
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 100 of 148 Bioassay Category Bioassay Details
In Vitro (Efficacy) Pupil diameter of rabbit eye 1 hour before treatment of compound at a dose of 1; untreated eye = 5 mm
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Activity
Unit
mM
Measurement Object
Pupil diameter
Qualitative value
=
Quantitative value
5
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 101 of 148 Target Name Target Synonyms
Alpha 2 adrenergic receptor [dog] alpha 2 adrenergic receptor
Target, Subunit, Species Alpha 2 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Apparent equilibrium dissociation constant (low affinity) of the compound towards dog alpha-2 adrenergic receptor using p-iodoclonidine as radioligand incubated for 120 min at 25 degree C determined by saturation analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Kd
Unit
nM
Qualitative value
=
Quantitative value
3.01
Measurement pX
8.52
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 102 of 148 Bioassay Category Bioassay Details
In Vitro (Efficacy) Mydriatic response in rabbit eye after treatment of compound at a dose of 2; Range = 2-4 mm change, untreated eye = 2-4 mm change
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Activity
Unit
mM
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Measurement Object
Mydriatic response in rabbit eye
Qualitative value
=
Quantitative value
4
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 103 of 148 Target Name Target Synonyms
Alpha 2 adrenergic receptor [dog] alpha 2 adrenergic receptor
Target, Subunit, Species Alpha 2 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Substance Action on Target
Inhibitor
Substance Effect
inhibitory activity
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Inhibitory concentration of the compound against dog alpha-2 adrenergic receptor using 44-45 pM p-125iodoclonidine as radioligand incubated for 120 min at 25 degree C
Substance RN
2802895View in Reaxys
Measurement Parameter
IC50
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 104 of 148 Bioassay Category Bioassay Details
In Vitro (Efficacy) Intraocular pressure in rabbit eye 5 hours after treatment of compound at a dose of 1; untreated eye = 23 mmHg
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Pressure
Unit
mmHg
Measurement Object
Intraocular pressure
Qualitative value
=
Quantitative value
18
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 105 of 148 Target Name Target Synonyms
Alpha 2 adrenergic receptor [dog] alpha 2 adrenergic receptor
Target, Subunit, Species Alpha 2 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Substance Action on Target
Radioligand (/ligand)
Substance Effect
binding activity
Bioassay Category
In Vitro (Efficacy)
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Bioassay Details
Apparent equilibrium dissociation constant (high affinity) of the compound towards dog alpha-2 adrenergic receptor using p-125iodoclonidine as radioligand incubated for 120 min at 25 degree C determined by saturation analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Kd
Unit
nM
Qualitative value
=
Quantitative value
0.15
Measurement pX
9.82
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 106 of 148 Bioassay Category Bioassay Details
In Vitro (Efficacy) Intraocular pressure in rabbit eye 5 hours after treatment of compound at a dose of 2; untreated eye = 21 mmHg
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Pressure
Unit
mmHg
Measurement Object
Intraocular pressure
Qualitative value
=
Quantitative value
18
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 107 of 148 Bioassay Category Bioassay Details
In Vitro (Efficacy) Mydriatic response in rabbit eye after treatment of compound at a dose of 1; Range = 0-2 mm change untreated eye = 0-2 mm change
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Activity
Unit
mM
Measurement Object
Mydriatic response in rabbit eye
Qualitative value
=
Quantitative value
2
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 108 of 148 Bioassay Category Bioassay Details
In Vitro (Efficacy) Intraocular pressure in rabbit eye half hour after treatment of compound at a dose of 2; untreated eye = 16 mmHg
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Pressure
Unit
mmHg
Measurement Object
Intraocular pressure
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Qualitative value
=
Quantitative value
15
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 109 of 148 Bioassay Category Bioassay Details
In Vitro (Efficacy) Intraocular pressure in rabbit eye 1 hour before treatment of compound at a dose of 2; untreated eye = 16 mmHg
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Pressure
Unit
mmHg
Measurement Object
Intraocular pressure
Qualitative value
=
Quantitative value
16
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 110 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Intraocular pressure in rabbit eye 1 hour after treatment of compound at a dose of 1; untreated eye = 18 mmHg
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Pressure
Unit
mmHg
Measurement Object
Intraocular pressure
Qualitative value
=
Quantitative value
17
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 111 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Intraocular pressure in rabbit eye 1 hour before treatment of compound at a dose of 1; untreated eye = 17 mmHg
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Pressure
Unit
mmHg
Measurement Object
Intraocular pressure
Qualitative value
=
Quantitative value
17
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 112 of 148
Target Name
Alpha 2 adrenergic receptor [dog]
Target Synonyms
alpha 2 adrenergic receptor
Target, Subunit, Species Alpha 2 adrenergic receptor [dog]
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Target Mutant/Chimera Details
Alpha 2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Number of low affinity binding sites of dog alpha-2 adrenergic receptor determined by Scatchard analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Qualitative
Measurement Object
BMAX2
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 113 of 148
Target Name
Alpha 2 adrenergic receptor [dog]
Target Synonyms
alpha 2 adrenergic receptor
Target, Subunit, Species Alpha 2 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Apparent equilibrium dissociation constant (high affinity) of the compound towards dog alpha-2 adrenergic receptor using p-125iodoclonidine as radioligand incubated for 120 min at 25 degree C determined by Scatchard analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Kd
Unit
nM
Qualitative value
=
Quantitative value
0.15
Measurement pX
9.82
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 114 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Pupil diameter of rabbit eye 3 hours after treatment of compound at a dose of 1; untreated eye = 6 mm
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Activity
Unit
mM
Measurement Object
Pupil diameter
Qualitative value
=
Quantitative value
6
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 115 of 148
Target Name
Alpha 1 adrenergic receptor [dog]
Target Synonyms
alpha 1 adrenergic receptor
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Target, Subunit, Species Alpha 1 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 1 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Substance Action on Target
Inhibitor
Substance Effect
inhibitory activity
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Inhibitory concentration of the compound against dog alpha-1 adrenergic receptor using 77.9 Ci/mmol [3H]Prazosin as radioligand incubated in 50 mM TRIS-HCl for 60 min at 25 degree C
Substance RN
2802895View in Reaxys
Measurement Parameter
IC50
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 116 of 148
Target Name
Alpha 1 adrenergic receptor [dog]
Target Synonyms
alpha 1 adrenergic receptor
Target, Subunit, Species Alpha 1 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 1 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Substance Action on Target
Radioligand (/ligand)
Substance Effect
binding activity
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Ratio of Binding affinity towards alpha-1 adrenergic receptor to that of beta-2 adrenergic receptor
Substance RN
2802895View in Reaxys
Measurement Parameter
Qualitative
Measurement Object
Ki ratio
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 117 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Pupil diameter of rabbit eye 1 hour before treatment of compound at a dose of 2; untreated eye = 6 mm
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Activity
Unit
mM
Measurement Object
Pupil diameter
Qualitative value
=
Quantitative value
6
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 118 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Pupil diameter of rabbit eye half hour before treatment of compound at a dose of 2; untreated eye = 6 mm
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Activity
Unit
mM
Measurement Object
Pupil diameter
Qualitative value
=
Quantitative value
6
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 119 of 148
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Intraocular pressure in rabbit eye 3 hours after treatment of compound at a dose of 1; untreated eye = 20 mmHg
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Pressure
Unit
mmHg
Measurement Object
Intraocular pressure
Qualitative value
=
Quantitative value
21
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 120 of 148 Target Name Target Synonyms
Alpha 1 adrenergic receptor [dog] alpha 1 adrenergic receptor
Target, Subunit, Species Alpha 1 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 1 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Ratio of Binding affinity towards alpha-1 adrenergic receptor to that of alpha-2 adrenergic receptor
Substance RN
2802895View in Reaxys
Measurement Parameter
Qualitative
Measurement Object
Ki ratio
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 121 of 148 Bioassay Category Bioassay Details
In Vitro (Efficacy) Pupil diameter of rabbit eye half hour after treatment of compound at a dose of 1; untreated eye = 6 mm
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Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Activity
Unit
mM
Measurement Object
Pupil diameter
Qualitative value
=
Quantitative value
6
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 122 of 148 Bioassay Category Bioassay Details
In Vitro (Efficacy) Pupil diameter of rabbit eye 1 hour after treatment of compound at a dose of 1; untreated eye = 6 mm
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Activity
Unit
mM
Measurement Object
Pupil diameter
Qualitative value
=
Quantitative value
6
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 123 of 148 Bioassay Category Bioassay Details
In Vitro (Efficacy) Pupil diameter of rabbit eye 5 hours after treatment of compound at a dose of 1; untreated eye = 6 mm
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Activity
Unit
mM
Measurement Object
Pupil diameter
Qualitative value
=
Quantitative value
6
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 124 of 148 Target Name
Beta-2 adrenergic receptor [dog]
Target Synonyms
adrb2; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor
Target Uniprot ID
p54833
Target, Subunit, Species Beta-2 adrenergic receptor [dog] Target Mutant/Chimera Details
Beta-2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Substance Action on Target
Radioligand (/ligand)
Substance Effect
binding activity
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Ratio of Binding affinity towards beta-2 adrenergic receptor to that of alpha-2 adrenergic receptor
Substance RN
2802895View in Reaxys
Measurement Parameter
Qualitative
Measurement Object
Ki ratio
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 125 of 148 Target Name
Beta-2 adrenergic receptor [dog]
Target Synonyms
adrb2; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor
Target Uniprot ID
p54833
Target, Subunit, Species Beta-2 adrenergic receptor [dog] Target Mutant/Chimera Details
Beta-2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Substance Action on Target
Radioligand (/ligand)
Substance Effect
binding activity
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Binding affinity of the compound against dog beta-2 adrenergic receptor using 2200Ci/ mmol [125I]CYP as radioligand incubated for 110 min at 30 degree C
Substance RN
2802895View in Reaxys
Measurement Parameter
Qualitative
Measurement Object
Ki
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 126 of 148 Target Name
Beta-2 adrenergic receptor [dog]
Target Synonyms
adrb2; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor
Target Uniprot ID
p54833
Target, Subunit, Species Beta-2 adrenergic receptor [dog] Target Mutant/Chimera Details
Beta-2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Number of binding sites (summary) of dog beta-2 adrenergic receptor determined by saturation analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Qualitative
Measurement Object
Bmax
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 127 of 148 Target Name
Beta-2 adrenergic receptor [dog]
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Target Synonyms
adrb2; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor
Target Uniprot ID
p54833
Target, Subunit, Species Beta-2 adrenergic receptor [dog] Target Mutant/Chimera Details
Beta-2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Number of binding sites (summary) of dog beta-2 adrenergic receptor determined by Scatchard analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Qualitative
Measurement Object
Bmax
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 128 of 148 Target Name Target Synonyms
Alpha 1 adrenergic receptor [dog] alpha 1 adrenergic receptor
Target, Subunit, Species Alpha 1 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 1 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Substance Action on Target
Radioligand (/ligand)
Substance Effect
binding activity
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Binding affinity of the compound against dog alpha-1 adrenergic receptor using 77.9 Ci/ mmol [3H]Prazosin as radioligand incubated in 50 mM TRIS-HCl for 60 min at 25 degree C
Substance RN
2802895View in Reaxys
Measurement Parameter
Qualitative
Measurement Object
Ki
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 129 of 148 Target Name
Beta-2 adrenergic receptor [dog]
Target Synonyms
adrb2; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor
Target Uniprot ID
p54833
Target, Subunit, Species Beta-2 adrenergic receptor [dog] Target Mutant/Chimera Details
Beta-2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Number of binding sites (run 1) of dog beta-2 adrenergic receptor determined by saturation analysis
Substance RN
2802895View in Reaxys
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Measurement Parameter
Qualitative
Measurement Object
Bmax
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 130 of 148 Target Name
Beta-2 adrenergic receptor [dog]
Target Synonyms
adrb2; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor
Target Uniprot ID
p54833
Target, Subunit, Species Beta-2 adrenergic receptor [dog] Target Mutant/Chimera Details
Beta-2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Number of binding sites (run 1) of dog beta-2 adrenergic receptor determined by Scatchard analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Qualitative
Measurement Object
Bmax
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 131 of 148 Target Name
Beta-2 adrenergic receptor [dog]
Target Synonyms
adrb2; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor
Target Uniprot ID
p54833
Target, Subunit, Species Beta-2 adrenergic receptor [dog] Target Mutant/Chimera Details
Beta-2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Apparent equilibrium dissociation constant (run 2) of the compound towards dog beta-2 adrenergic receptor using 125ICYP as radioligand incubated for 110 min at 30 degree C determined by saturation analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Kd
Unit
pM
Qualitative value
=
Quantitative value
9.3
Measurement pX
11
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 132 of 148 Target Name
Beta-2 adrenergic receptor [dog]
Target Synonyms
adrb2; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor
Target Uniprot ID
p54833
Target, Subunit, Species Beta-2 adrenergic receptor [dog]
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Target Mutant/Chimera Details
Beta-2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Apparent equilibrium dissociation constant (summary) of the compound towards dog beta-2 adrenergic receptor using 125ICYP as radioligand incubated for 110 min at 30 degree C determined by saturation analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Kd
Unit
pM
Qualitative value
=
Quantitative value
9.5
Measurement pX
11
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 133 of 148 Target Name
Beta-2 adrenergic receptor [dog]
Target Synonyms
adrb2; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor
Target Uniprot ID
p54833
Target, Subunit, Species Beta-2 adrenergic receptor [dog] Target Mutant/Chimera Details
Beta-2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Apparent equilibrium dissociation constant (summary) of the compound towards dog beta-2 adrenergic receptor using 125ICYP as radioligand incubated for 110 min at 30 degree C determined by Scatchard analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Kd
Unit
pM
Qualitative value
=
Quantitative value
8.9
Measurement pX
11.1
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 134 of 148 Target Name
Beta-2 adrenergic receptor [dog]
Target Synonyms
adrb2; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor
Target Uniprot ID
p54833
Target, Subunit, Species Beta-2 adrenergic receptor [dog] Target Mutant/Chimera Details
Beta-2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Apparent equilibrium dissociation constant (run 1) of the compound towards dog beta-2 adrenergic receptor using 125ICYP as radioligand incubated for 110 min at 30 degree C determined by Scatchard analysis
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Substance RN
2802895View in Reaxys
Measurement Parameter
Kd
Unit
pM
Qualitative value
=
Quantitative value
9.9
Measurement pX
11
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 135 of 148 Target Name
Beta-2 adrenergic receptor [dog]
Target Synonyms
adrb2; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor
Target Uniprot ID
p54833
Target, Subunit, Species Beta-2 adrenergic receptor [dog] Target Mutant/Chimera Details
Beta-2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Number of binding sites (run 2) of dog beta-2 adrenergic receptor determined by Scatchard analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Qualitative
Measurement Object
Bmax
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 136 of 148 Target Name
Beta-2 adrenergic receptor [dog]
Target Synonyms
adrb2; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor
Target Uniprot ID
p54833
Target, Subunit, Species Beta-2 adrenergic receptor [dog] Target Mutant/Chimera Details
Beta-2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Number of binding sites (run 2) of dog beta-2 adrenergic receptor determined by saturation analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Qualitative
Measurement Object
Bmax
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 137 of 148 Target Name
Beta-2 adrenergic receptor [dog]
Target Synonyms
adrb2; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor
Target Uniprot ID
p54833
Target, Subunit, Species Beta-2 adrenergic receptor [dog]
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Target Mutant/Chimera Details
Beta-2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Substance Action on Target
Inhibitor
Substance Effect
inhibitory activity
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Inhibitory concentration of the compound against dog beta-2 adrenergic receptor using 2200Ci/mmol 125ICYP as radioligand incubated for 110 min at 30 degree C
Substance RN
2802895View in Reaxys
Measurement Parameter
IC50
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 138 of 148 Target Name
Beta-2 adrenergic receptor [dog]
Target Synonyms
adrb2; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor
Target Uniprot ID
p54833
Target, Subunit, Species Beta-2 adrenergic receptor [dog] Target Mutant/Chimera Details
Beta-2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Apparent equilibrium dissociation constant (run 1) of the compound towards dog beta-2 adrenergic receptor using 125ICYPas radioligand incubated for 110 min at 30 degree C determined by saturation analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Kd
Unit
pM
Qualitative value
=
Quantitative value
9.6
Measurement pX
11
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 139 of 148 Target Name Target Synonyms
Alpha 1 adrenergic receptor [dog] alpha 1 adrenergic receptor
Target, Subunit, Species Alpha 1 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 1 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Number of binding sites of dog alpha-1 adrenergic receptor determined by saturation analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Qualitative
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
65/69
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Measurement Object
Bmax
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 140 of 148 Target Name
Beta-2 adrenergic receptor [dog]
Target Synonyms
adrb2; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor
Target Uniprot ID
p54833
Target, Subunit, Species Beta-2 adrenergic receptor [dog] Target Mutant/Chimera Details
Beta-2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Substance Action on Target
Radioligand (/ligand)
Substance Effect
binding activity
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Apparent equilibrium dissociation constant (run 2) of the compound towards dog beta-2 adrenergic receptor using 125ICYP as radioligand incubated for 110 min at 30 degree C determined by scatchard analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Kd
Unit
pM
Qualitative value
=
Quantitative value
7.8
Measurement pX
11.1
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 141 of 148 Bioassay Category Bioassay Details
In Vitro (Efficacy) Intraocular pressure in rabbit eye half hour after treatment of compound at a dose of 1; untreated eye = 21 mmHg
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Pressure
Unit
mmHg
Measurement Object
Intraocular pressure
Qualitative value
=
Quantitative value
17
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 142 of 148 Bioassay Category Bioassay Details
In Vitro (Efficacy) Intraocular pressure in rabbit eye half hour before treatment of compound at a dose of 1; untreated eye = 20 mmHg
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Pressure
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Unit
mmHg
Measurement Object
Intraocular pressure
Qualitative value
=
Quantitative value
18
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 143 of 148 Target Name Target Synonyms
Alpha 1 adrenergic receptor [dog] alpha 1 adrenergic receptor
Target, Subunit, Species Alpha 1 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 1 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Number of binding sites of dog alpha-1 adrenergic receptor determined by Scatchard analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Qualitative
Measurement Object
Bmax
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 144 of 148 Target Name Target Synonyms
Alpha 1 adrenergic receptor [dog] alpha 1 adrenergic receptor
Target, Subunit, Species Alpha 1 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 1 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Apparent equilibrium dissociation constant of the compound towards dog alpha-1 adrenergic receptor using 3H-Prazocin as radioligand incubated for 60 min at 25 degree C determined by saturation analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Kd
Unit
nM
Qualitative value
=
Quantitative value
0.73
Measurement pX
9.14
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 145 of 148 Target Name Target Synonyms
Alpha 1 adrenergic receptor [dog] alpha 1 adrenergic receptor
Target, Subunit, Species Alpha 1 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 1 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
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Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Apparent equilibrium dissociation constant of the compound towards dog alpha-1 adrenergic receptor using 3H-Prazocin as radioligand incubated for 60 min at 25 degree C determined by Scatchard analysis
Substance RN
2802895View in Reaxys
Measurement Parameter
Kd
Unit
nM
Qualitative value
=
Quantitative value
0.84
Measurement pX
9.08
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 146 of 148 Bioassay Category Bioassay Details
In Vitro (Efficacy) Intraocular pressure in rabbit eye 1 hour after treatment of compound at a dose of 2; untreated eye = 19 mmHg
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Pressure
Unit
mmHg
Measurement Object
Intraocular pressure
Qualitative value
=
Quantitative value
18
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 147 of 148 Bioassay Category Bioassay Details
In Vitro (Efficacy) Pupil diameter of rabbit eye half hour after treatment of compound at a dose of 2; untreated eye = 9 mm
Biological Species/NCBI rabbit ID Substance RN
2802895View in Reaxys
Measurement Parameter
Activity
Unit
mM
Measurement Object
Pupil diameter
Qualitative value
=
Quantitative value
9
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys 148 of 148 Target Name Target Synonyms
Alpha 2 adrenergic receptor [dog] alpha 2 adrenergic receptor
Target, Subunit, Species Alpha 2 adrenergic receptor [dog] Target Mutant/Chimera Details
Alpha 2 adrenergic receptor [dog]:Wild
Target Species (Bioactivity)
dog
Substance Action on Target
Radioligand (/ligand)
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Substance Effect
binding activity
Bioassay Category
In Vitro (Efficacy)
Bioassay Details
Binding affinity of the compound against dog alpha-2 adrenergic receptor using 44-45 pM p-125iodoclonidine as radioligand incubated for 120 min at 25 degree C
Substance RN
2802895View in Reaxys
Measurement Parameter
Qualitative
Measurement Object
Ki
Qualitative value
Not Published
Patent; BOOTH Anthony; CAFFREY James L; US2004/73043; (A1); (2004), View in Reaxys
Copyright © 2017 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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