[4] (1S,2R)-(+)-Norephedrine hydrochloride [C9H13NO·ClH] [CAS 40626-29-7; InChIKey DYWNLSQWJM by Asch

Query Query Cl

Results

Date

2 substances in Reaxys

2017-11-08 16h:36m:21s (EST)

1 substances in Reaxys

2017-11-08 16h:36m:45s (EST)

1. Query H 2N

Search as: As drawn, No salts, No mixtures, No isotopes, No charges, No radicals 2. Query

(1. Query) AND itemno in (1)

1/59

2017-11-08 16:39:50

Reaxys ID 4357479 View in Reaxys

1/1 CAS Registry Number: 40626-29-7 Chemical Name: Acutrim; (1S,2R)-1-hydroxy-1-phenylprop-2ylamine hydrochloride; Norephedrine hydrochloride; (1S,2R)(+)-1-phenyl-2-amino-1-propanol hydrochloride; (1S,2R)-1-phenylpropan-1-ol-2-amine hydrochloride; (1S,2R)-2-amino-1-phenylpropan-1-ol hydrochloride; (1S,2R)-(+)-norephedrine hydrochloride Linear Structure Formula: C9H13NO*HCl Molecular Formula: C9H13NO*ClH Molecular Weight: 187.669 Type of Substance: isocyclic InChI Key: DYWNLSQWJMTVGJ-PRCZDLBKSA-N Note:

HO H 2N

Substance Label (3) Label References 1

Chennakesava Rao; Easwaramoorthi; Arun; Balachandran; Muralidhara Rao; Govindhan; Emi, Nobuhiko; Prakasam; Perumal; Bioorganic and Medicinal Chemistry Letters; vol. 25; nb. 19; (2015); p. 4232 4238, View in Reaxys

1b-(e)

Cruz, Alejandro; Contreras, Rosalinda; Padilla-Martinez, Itzia I.; Juarez-Juarez, Minerva; Tetrahedron Asymmetry; vol. 17; nb. 10; (2006); p. 1499 - 1505, View in Reaxys

Wiles, Charlotte; Watts, Paul; Haswell, Stephen J.; Pombo-Villar, Esteban; Tetrahedron; vol. 61; nb. 45; (2005); p. 10757 - 10773, View in Reaxys

Druglikeness (1) 1 of 1

LogP

1.51

H Bond Donors

H Bond Acceptors

Rotatable Bonds

TPSA

46.25

Lipinski Number

Veber Number

Highest Clinical Phase (1) Highest Clinical Phase Withdrawn Derivative (1) Derivative (1S,2R)-norephedrine hydrothiocyanate

References Cruz, Alejandro; Contreras, Rosalinda; Padilla-Martinez, Itzia I.; Juarez-Juarez, Minerva; Tetrahedron Asymmetry; vol. 17; nb. 10; (2006); p. 1499 - 1505, View in Reaxys

Melting Point (3) 1 of 3

Melting Point [°C]

171 - 173

Location

Paragraph 048

Patent; EMBIO LIMITED; JOSHI, Sunil Vaman; BUTALA, Minal Madhukar; GOLLAPUDY, Subrahmanyam; WO2015/198108; (2015); (A1) English, View in Reaxys 2 of 3

Melting Point [°C]

173

Beyrich; Junghaenel; Mietz; Hauschke; Pharmazie; vol. 52; nb. 7; (1997); p. 512 - 516, View in Reaxys 3 of 3

Melting Point [°C]

171 - 172

Solvent (Melting Point)

ethanol

Kanao; Chemische Berichte; vol. 63; (1930); p. 97, View in Reaxys Association (MCS) (1) 1 of 1

Description (Association Stability constant of the complex with ... (MCS))

2/59

2017-11-08 16:39:50

Solvent (Association (MCS))

dimethylsulfoxide-d6; H2O

Temperature (Association (MCS)) [°C]

Partner (Association (MCS))

tetrabutylammonium m-xylene bis(methylphosphonate)

Schrader, Thomas; Angewandte Chemie; vol. 108; nb. 22; (1996); p. 2816 - 2818, View in Reaxys Crystal Property Description (1) Colour & Other References Properties hygroskopische Tafeln

Kanao; Chemische Berichte; vol. 63; (1930); p. 97, View in Reaxys

Enthalpy of Fusion (1) Enthalpy of FuReferences sion [Jmol-1] 14900

Beyrich; Junghaenel; Mietz; Hauschke; Pharmazie; vol. 52; nb. 7; (1997); p. 512 - 516, View in Reaxys

Liquid/Solid Systems (MCS) (1) 1 of 1

Description (Liquid/Solid Eutectic Systems (MCS)) Partner (Liquid/Solid Systems (MCS))

norephedrine hydrochloride

Beyrich; Junghaenel; Mietz; Hauschke; Pharmazie; vol. 52; nb. 7; (1997); p. 512 - 516, View in Reaxys Mutarotation (1) 1 of 1

Type (Mutarotation)

[alpha]

Concentration (Mutarotation)

p=6

Solvent (Mutarotation)

H2O

Mutarotation [deg]

33.4

Wavelength (Mutarotation) [nm]

589

Temperature (Mutarotation) [°C]

Kanao; Chemische Berichte; vol. 63; (1930); p. 97, View in Reaxys Optical Rotatory Power (4) 1 of 4

Type (Optical Rotatory Power)

[alpha]

Concentration (Optical Rotatory Power)

0.7 g/100ml

Solvent (Optical Rotatory Power)

H2O

Optical Rotatory Power [deg]

34.9

Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]

Effenberger, Franz; Gutterer, Beate; Ziegler, Thomas; Liebigs Annalen der Chemie; nb. 3; (1991); p. 269 - 273, View in Reaxys 2 of 4

Type (Optical Rotatory Power)

[alpha]

Concentration (Optical Rotatory Power)

1.2 g/100ml

3/59

2017-11-08 16:39:50

Solvent (Optical Rotatory Power)

H2O

Optical Rotatory Power [deg]

33.2

Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]

Noe, Christian R.; Knollmueller, Max; Goestl, Georg; Gaertner, Peter; Monatshefte fuer Chemie; vol. 122; nb. 4; (1991); p. 283 - 290, View in Reaxys 3 of 4

Type (Optical Rotatory Power)

[alpha]

Concentration (Optical Rotatory Power)

7.3 g/100ml

Solvent (Optical Rotatory Power)

H2O

Optical Rotatory Power [deg]

33.9

Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]

Grunewald; Ye; Journal of Medicinal Chemistry; vol. 31; nb. 10; (1988); p. 1984 - 1986, View in Reaxys 4 of 4

Type (Optical Rotatory Power)

[alpha]

Concentration (Optical Rotatory Power)

1 g/100ml

Solvent (Optical Rotatory Power)

H2O

Optical Rotatory Power [deg]

Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]

Berrang; Lewin; Carroll; Journal of Organic Chemistry; vol. 47; nb. 13; (1982); p. 2643 - 2647, View in Reaxys NMR Spectroscopy (2) 1 of 2

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

Solvents (NMR Spectro- dimethylsulfoxide-d6 scopy) Effenberger, Franz; Gutterer, Beate; Ziegler, Thomas; Liebigs Annalen der Chemie; nb. 3; (1991); p. 269 - 273, View in Reaxys 2 of 2

Description (NMR Spec- Spin-spin coupling constants troscopy) Solvents (NMR Spectro- dimethylsulfoxide-d6 scopy) Comment (NMR Spectroscopy)

1H-1H

Effenberger, Franz; Gutterer, Beate; Ziegler, Thomas; Liebigs Annalen der Chemie; nb. 3; (1991); p. 269 - 273, View in Reaxys

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Raman Spectroscopy (1) Description (Ram- Comment (Raman Spectroscopy) an Spectroscopy) Spectrum

H2O

References Yu, Gu-Sheng; Che, Diping; Freedman, Teresa B.; Nafie, Laurence A.; Tetrahedron: Asymmetry; vol. 4; nb. 3; (1993); p. 511 - 516, View in Reaxys

Medchem (143) 1 of 143

Target Name

Alpha adrenergic receptor [rabbit]

Target Synonyms

alpha adrenergic receptor

Target, Subunit, Species Alpha adrenergic receptor [rabbit] Target Mutant/Chimera Details

Alpha adrenergic receptor [rabbit]:Wild

Target Species (Bioactivity)

rabbit

Target Transfection

Non Transfected

Substance Action on Target

Agonist

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Organ contraction

Biological Species/NCBI rabbit ID

2 of 143

Organs/Tissues

Intestine: ileum

Substance RN

4357479View in Reaxys

Substance Name

phenylpropanolamine

Measurement Parameter

EC50

Unit

µM

Quantitative value

5.32

Measurement pX

5.27

Concomitants: Compound RN

272944

Concomitants: Compound name

Phentolamine

Concomitants: Compound role

COM

Target Name

Alpha adrenergic receptor [rabbit]

Target Synonyms

alpha adrenergic receptor

Target, Subunit, Species Alpha adrenergic receptor [rabbit] Target Mutant/Chimera Details

Alpha adrenergic receptor [rabbit]:Wild

Target Species (Bioactivity)

rabbit

Target Transfection

Non Transfected

Substance Action on Target

Agonist

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

Organ contraction

Biological Species/NCBI rabbit ID Organs/Tissues

Uterus

5/59

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3 of 143

Substance RN

4357479View in Reaxys

Substance Name

phenylpropanolamine

Measurement Parameter

EC50

Unit

µM

Quantitative value

5.8

Measurement pX

5.24

Concomitants: Compound RN

272944

Concomitants: Compound name

Phentolamine

Concomitants: Compound role

COM

Target Name

Amine oxidase [flavin-containing] A [Rattus norvegicus]

Target Synonyms

amine oxidase; mao-a; maoa; monoamine oxidase type a

Target Uniprot ID

p21396

Target PDB ID

1o5w

Target, Subunit, Species Amine oxidase [flavin-containing] A [Rattus norvegicus] Target Mutant/Chimera Details

Amine oxidase [flavin-containing] A [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI Sprague Dawley rat ID

4 of 143

Organs/Tissues

lung

Cell Fraction

Homogenate

Substance RN

4357479View in Reaxys

Substance Name

d,l-Norephedrine HCl

Measurement Parameter

Unit

µM

Quantitative value

243

Deviation

Measurement pX

3.61

Metabolite RN

1453495

Metabolite name

5-hydroxyindole-3-acetaldehyde

Concomitants: Compound RN

3886526

Concomitants: Compound name

[14C]-5-HT creatinine sulfate

Concomitants: Compound role

SUB

Target Name

Amine oxidase [flavin-containing] A [Rattus norvegicus]

Target Synonyms

amine oxidase; mao-a; maoa; monoamine oxidase type a

6/59

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Target Uniprot ID

p21396

Target PDB ID

1o5w

Target, Subunit, Species Amine oxidase [flavin-containing] A [Rattus norvegicus] Target Mutant/Chimera Details

Amine oxidase [flavin-containing] A [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI Sprague Dawley rat ID

5 of 143

Organs/Tissues

liver

Cell Fraction

Homogenate

Substance RN

4357479View in Reaxys

Substance Name

d,l-Norephedrine HCl

Measurement Parameter

Unit

µM

Quantitative value

267

Deviation

Measurement pX

3.57

Metabolite RN

1453495

Metabolite name

5-hydroxyindole-3-acetaldehyde

Concomitants: Compound RN

3886526

Concomitants: Compound name

[14C]-5-HT creatinine sulfate

Concomitants: Compound role

SUB

Target Name

Amine oxidase [flavin-containing] A [Rattus norvegicus]

Target Synonyms

amine oxidase; mao-a; maoa; monoamine oxidase type a

Target Uniprot ID

p21396

Target PDB ID

1o5w

Target, Subunit, Species Amine oxidase [flavin-containing] A [Rattus norvegicus] Target Mutant/Chimera Details

Amine oxidase [flavin-containing] A [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI Sprague Dawley rat ID Organs/Tissues

brain

Cell Fraction

Homogenate

7/59

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6 of 143

Substance RN

4357479View in Reaxys

Substance Name

d,l-Norephedrine HCl

Measurement Parameter

Unit

µM

Quantitative value

222

Deviation

Measurement pX

3.65

Metabolite RN

1453495

Metabolite name

5-hydroxyindole-3-acetaldehyde

Concomitants: Compound RN

3886526

Concomitants: Compound name

[14C]-5-HT creatinine sulfate

Concomitants: Compound role

SUB

Target Name

Amine oxidase [flavin-containing] A [Rattus norvegicus]

Target Synonyms

amine oxidase; mao-a; maoa; monoamine oxidase type a

Target Uniprot ID

p21396

Target PDB ID

1o5w

Target, Subunit, Species Amine oxidase [flavin-containing] A [Rattus norvegicus] Target Mutant/Chimera Details

Amine oxidase [flavin-containing] A [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI Sprague Dawley rat ID Organs/Tissues

lung

Cell Fraction

Homogenate

Substance RN

4357479View in Reaxys

Substance Name

d,l-Norephedrine HCl

Measurement Parameter

Unit

µM

Quantitative value

3400

Deviation

650

Measurement pX

2.47

Metabolite RN

505944

Metabolite name

Ethanolamine

Concomitants: Compound RN

3624163

Concomitants: Compound name

[14C]-beta-Phenylethylamine hydrochloride

8/59

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7 of 143

Concomitants: Compound role

SUB

Target Name

Amine oxidase [flavin-containing] A [Rattus norvegicus]

Target Synonyms

amine oxidase; mao-a; maoa; monoamine oxidase type a

Target Uniprot ID

p21396

Target PDB ID

1o5w

Target, Subunit, Species Amine oxidase [flavin-containing] A [Rattus norvegicus] Target Mutant/Chimera Details

Amine oxidase [flavin-containing] A [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI Sprague Dawley rat ID

8 of 143

Organs/Tissues

liver

Cell Fraction

Homogenate

Substance RN

4357479View in Reaxys

Substance Name

d,l-Norephedrine HCl

Measurement Parameter

Unit

µM

Quantitative value

3300

Deviation

850

Measurement pX

2.48

Metabolite RN

505944

Metabolite name

Ethanolamine

Concomitants: Compound RN

3624163

Concomitants: Compound name

[14C]-beta-Phenylethylamine hydrochloride

Concomitants: Compound role

SUB

Target Name

Amine oxidase [flavin-containing] A [Rattus norvegicus]

Target Synonyms

amine oxidase; mao-a; maoa; monoamine oxidase type a

Target Uniprot ID

p21396

Target PDB ID

1o5w

Target, Subunit, Species Amine oxidase [flavin-containing] A [Rattus norvegicus] Target Mutant/Chimera Details

Amine oxidase [flavin-containing] A [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

9/59

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Biological Species/NCBI Sprague Dawley rat ID

9 of 143

Organs/Tissues

brain

Cell Fraction

Homogenate

Substance RN

4357479View in Reaxys

Substance Name

d,l-Norephedrine HCl

Measurement Parameter

Unit

µM

Quantitative value

2600

Deviation

820

Measurement pX

2.59

Metabolite RN

505944

Metabolite name

Ethanolamine

Concomitants: Compound RN

3624163

Concomitants: Compound name

[14C]-beta-Phenylethylamine hydrochloride

Concomitants: Compound role

SUB

Target Name

Amine oxidase [flavin-containing] A [Rattus norvegicus]

Target Synonyms

amine oxidase; mao-a; maoa; monoamine oxidase type a

Target Uniprot ID

p21396

Target PDB ID

1o5w

Target, Subunit, Species Amine oxidase [flavin-containing] A [Rattus norvegicus] Target Mutant/Chimera Details

Amine oxidase [flavin-containing] A [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI Sprague Dawley rat ID Organs/Tissues

liver

Cell Fraction

Homogenate

Substance RN

4357479View in Reaxys

Substance Name

d,l-Norephedrine HCl

Substance Dose

0.250000 mM

Measurement Parameter

% Inhibition

Unit

Quantitative value

0.47

Measurement pX

Metabolite RN

1453495

Metabolite name

5-hydroxyindole-3-acetaldehyde

10/59

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10 of 143

Concomitants: Compound RN

3886526

Concomitants: Compound name

[14C]-5-HT creatinine sulfate

Concomitants: Compound role

SUB

Target Name

Amine oxidase [flavin-containing] A [Rattus norvegicus]

Target Synonyms

amine oxidase; mao-a; maoa; monoamine oxidase type a

Target Uniprot ID

p21396

Target PDB ID

1o5w

Target, Subunit, Species Amine oxidase [flavin-containing] A [Rattus norvegicus] Target Mutant/Chimera Details

Amine oxidase [flavin-containing] A [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Target Transfection

Non Transfected

Bioassay Category

Metabolism/Transport

Bioassay Name

Enzymology inhibition

Biological Species/NCBI Sprague Dawley rat ID

11 of 143

Organs/Tissues

liver

Cell Fraction

Homogenate

Substance RN

4357479View in Reaxys

Substance Name

d,l-Norephedrine HCl

Substance Dose

0.330000 mM

Measurement Parameter

% Inhibition

Unit

Quantitative value

0.77

Measurement pX

Metabolite RN

1453495

Metabolite name

5-hydroxyindole-3-acetaldehyde

Concomitants: Compound RN

3886526

Concomitants: Compound name

[14C]-5-HT creatinine sulfate

Concomitants: Compound role

SUB

Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Bioassay Details

Effect : |transport Bioassay : Ki,cl,NMeN=contraluminal apparent Ki against N1-methylnicotinamide (NMEN), Ki,l,choline=luminal apparent Ki against choline, Ki,l,MPP=luminal apparent Ki against MPP, 3H-NMeN and 14C-inulin (0.01 mM) used as volume and/or space in vitro; kidney capsules (proximal tubule) from rats (180-200 g); luminal stop flow tubular microperfusion method; 37 degC; title comp. and 3H-methyl-4-phenylpyridinium (MPP) (0.01 mM) or 3H-choline+ (0.01 mM) applied in HCO3- Ringer's

Biological Species/NCBI Rattus norvegicus ID Substance RN

4357479View in Reaxys

11/59

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Substance Name

1503645

Qualitative Results

Ki,cl,NmeN=1.4 mM; Ki,l,MPP=5.1 mM; Ki,l,choline=12.4 mM

Measurement Parameter

Qualitative

Somogyi, Andrew A.; Rumrich, Gerhard; Fritzsch, Guenter; Ullrich, Karl J.; Journal of Pharmacology and Experimental Therapeutics; vol. 278; nb. 1; (1996); p. 31 - 36, View in Reaxys 12 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Substance Name

phenylpropanolamine HCL

Substance Route of Adm.

oral administration

Measurement Parameter

Cmax i/Cmax

Qualitative value

Quantitative value

1.2

Metabolite RN

4298024; 4298023

Metabolite name

(-)-Warfarin; (+)-Warfarin

Concomitants: Compound RN

7496939

Concomitants: Compound name

Linezolid

Concomitants: Compound role

ICP

; (2000); Type: Clinical Pharmacology Biopharmaceutics Review, Lab: NDA021130-021131-021132, Owner: PHARMACIA AND UPJOHN, Number: 000, Revision: 18.04.2000 00:00:00, View in Reaxys 13 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Substance Name

phenylpropanolamine HCL

Substance Route of Adm.

oral administration

Measurement Parameter

AUC i/AUC

Qualitative value

Quantitative value

1.22

Concomitants: Compound RN

7496939

Concomitants: Compound name

Linezolid

Concomitants: Compound role

ICP

; (2000); Type: Clinical Pharmacology Biopharmaceutics Review, Lab: NDA021130-021131-021132, Owner: PHARMACIA AND UPJOHN, Number: 000, Revision: 18.04.2000 00:00:00, View in Reaxys 14 of 143

Substance Effect

Decongestant

12/59

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Bioassay Category

In Vitro (Efficacy)

Bioassay Name

In Vitro (others)

Substance RN

4357479View in Reaxys

Substance Name

Norephedrine hydrochloride

Measurement Parameter

Qualitative

Qualitative value

; (2012); Type: Review, Lab: EFF_071212, Owner: EFFECT, Number: 000, Revision: 07.12.2012 00:00:00, View in Reaxys 15 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Healthy

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine HCl

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Ue (%)

Unit

Quantitative value

Deviation

Chester, Neil; Mottram, David R.; Reilly, Thomas; Powell, Mark; British Journal of Clinical Pharmacology; vol. 57; nb. 1; (2004); p. 62 - 67, View in Reaxys 16 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Healthy

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine HCl

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Cmax

Unit

mg/L

Quantitative value

Deviation

Chester, Neil; Mottram, David R.; Reilly, Thomas; Powell, Mark; British Journal of Clinical Pharmacology; vol. 57; nb. 1; (2004); p. 62 - 67, View in Reaxys

13/59

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17 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Healthy

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine HCl

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Tmax

Unit

hour

Quantitative value

Chester, Neil; Mottram, David R.; Reilly, Thomas; Powell, Mark; British Journal of Clinical Pharmacology; vol. 57; nb. 1; (2004); p. 62 - 67, View in Reaxys 18 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Healthy

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine HCl

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Quantitative value

6.3

Deviation

0.300000

Chester, Neil; Mottram, David R.; Reilly, Thomas; Powell, Mark; British Journal of Clinical Pharmacology; vol. 57; nb. 1; (2004); p. 62 - 67, View in Reaxys 19 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

50 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men

14/59

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Measurement Parameter

Cmax

Unit

ng/mL

Quantitative value

182.28

Deviation

27.2200

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 20 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

Cmax

Unit

ng/mL

Quantitative value

113.12

Deviation

45.8600

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 21 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

100 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

Cmax

Unit

ng/mL

Quantitative value

396.82

Deviation

69.9400

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 22 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID

15/59

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Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

50 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

Tmax

Unit

hour

Quantitative value

Deviation

0.500000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 23 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

100 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

Tmax

Unit

hour

Quantitative value

1.7

Deviation

0.570000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 24 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

Tmax

Unit

hour

16/59

2017-11-08 16:39:50

Quantitative value

1.47

Deviation

0.950000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 25 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

AUC

Unit

ng.h/mL

Quantitative value

610.57

Deviation

103.240

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 26 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

50 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

AUC

Unit

ng.h/mL

Quantitative value

1170.98

Deviation

146.480

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 27 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

17/59

2017-11-08 16:39:50

Substance Dose

100 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

AUC

Unit

ng.h/mL

Quantitative value

2530.8

Deviation

563.870

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 28 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

kabs

Unit

h-1

Quantitative value

3.38

Deviation

2.55000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 29 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

100 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

kabs

Unit

h-1

Quantitative value

3.27

Deviation

2.89000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys

18/59

2017-11-08 16:39:50

30 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

50 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

kabs

Unit

h-1

Quantitative value

3.83

Deviation

3.52000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 31 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

kel

Unit

h-1

Quantitative value

0.16

Deviation

0.0100000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 32 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

100 mg

Substance Route of Adm.

oral administration

19/59

2017-11-08 16:39:50

Substance Dosing Regi- Single men Measurement Parameter

kel

Unit

h-1

Quantitative value

0.17

Deviation

0.0100000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 33 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

50 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

kel

Unit

h-1

Quantitative value

0.18

Deviation

0.0200000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 34 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

t1/2 el

Unit

hour

Quantitative value

4.39

Deviation

0.390000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 35 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

20/59

2017-11-08 16:39:50

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

50 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

t1/2 el

Unit

hour

Quantitative value

3.86

Deviation

0.400000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 36 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

100 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

t1/2 el

Unit

hour

Quantitative value

3.8

Deviation

0.830000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 37 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

50 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men

21/59

2017-11-08 16:39:50

Measurement Parameter

Vd/F

Unit

L/kg

Quantitative value

3.18

Deviation

0.700000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 38 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

Vd/F

Unit

L/kg

Quantitative value

3.26

Deviation

0.750000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 39 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

100 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

Vd/F

Unit

L/kg

Quantitative value

2.96

Deviation

0.860000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 40 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID

22/59

2017-11-08 16:39:50

Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

50 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

ClR

Unit

L/h/kg

Quantitative value

0.42

Deviation

0.0300000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 41 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

ClR

Unit

L/h/kg

Quantitative value

0.41

Deviation

0.0900000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 42 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

100 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

ClR

Unit

L/h/kg

23/59

2017-11-08 16:39:50

Quantitative value

0.44

Deviation

0.110000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 43 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

100 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

Cl/F

Unit

L/h/kg

Quantitative value

0.53

Deviation

0.0800000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 44 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

50 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

Cl/F

Unit

L/h/kg

Quantitative value

0.57

Deviation

0.120000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 45 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

24/59

2017-11-08 16:39:50

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

Cl/F

Unit

L/h/kg

Quantitative value

0.56

Deviation

0.150000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 46 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

Ue (%)

Unit

Quantitative value

64.02

Deviation

10.3500

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 47 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

100 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

Ue (%)

Unit

Quantitative value

73.26

Deviation

10.6600

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys

25/59

2017-11-08 16:39:50

48 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

50 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Single men Measurement Parameter

Ue (%)

Unit

Quantitative value

63.3

Deviation

8.50000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 49 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Cmax

Unit

ng/mL

Quantitative value

182.79

Deviation

11.1200

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 50 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

25 mg

Substance Route of Adm.

oral administration

26/59

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Substance Dosing Regi- Repeated men Measurement Parameter

Cmin

Unit

ng/mL

Quantitative value

112.79

Deviation

30.2800

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 51 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

AUC

Unit

ng.h/mL

Quantitative value

559.79

Deviation

63.9000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 52 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Concentration

Unit

ng/mL

Quantitative value

137.88

Deviation

26.9800

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 53 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

27/59

2017-11-08 16:39:50

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

kel

Unit

h-1

Quantitative value

0.15

Deviation

0.0100000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 54 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

t1/2 el

Unit

hour

Quantitative value

4.71

Deviation

0.370000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 55 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men

28/59

2017-11-08 16:39:50

Measurement Parameter

Vd/F

Unit

L/kg

Quantitative value

4.08

Deviation

0.910000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 56 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Cl/F

Unit

L/h/kg

Quantitative value

0.5

Deviation

0.0900000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 57 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Tmax

Unit

hour

Quantitative value

0.73

Deviation

0.250000

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 58 of 143

Bioassay Category

Pharmacokinetic

Bioassay Name

Pharmacokinetic

Biological Species/NCBI Human ID

29/59

2017-11-08 16:39:50

Population State

Non Smoker

Substance RN

4357479View in Reaxys

Substance Name

Phenylpropanolamine hydrochloride

Substance Dose

25 mg

Substance Route of Adm.

oral administration

Substance Dosing Regi- Repeated men Measurement Parameter

Cavg

Unit

ng/mL

Quantitative value

140

Scherzinger; Dowse; Kanfer; Journal of Clinical Pharmacology; vol. 30; nb. 4; (1990); p. 372 - 377, View in Reaxys 59 of 143

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lowest toxic dose of the compound in human after oral administration

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Substance Route of Adm.

oral administration

Qualitative Results

2.142

Measurement Parameter

TDLo

Unit

mg/kg

Measurement Object

Lowest toxic dose

Quantitative value

2.142

Lake; Zaloga; Clymer; Quirk; Chernow; American Journal of Medicine; vol. 85; nb. 3; (1988); p. 339 - 343, View in Reaxys 60 of 143

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Tested for inhibition of Norepinephrine uptake in isolated rat heart measured as the log of reciprocal of I50 concentration relative to phenethylamine = 100 (uptake1)

Biological Species/NCBI Rattus norvegicus ID Organs/Tissues

Heart

Substance RN

4357479View in Reaxys

Measurement Parameter

Qualitative

Measurement Object

log A

Ban; Fujita; Journal of medicinal chemistry; vol. 12; nb. 3; (1969); p. 353 - 356, View in Reaxys 61 of 143

Target Name

Phenylethanolamine N-methyltransferase [Cercopithecidae]

Target Synonyms

phenylethanolamine n-methyltransferase

Target, Subunit, Species Phenylethanolamine N-methyltransferase [Cercopithecidae] Target Mutant/Chimera Details

Phenylethanolamine N-methyltransferase [Cercopithecidae]:Wild

Target Species (Bioactivity)

Cercopithecidae

Bioassay Category

In Vitro (Efficacy)

30/59

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Bioassay Details

Effect of the compound towards Phenylethanolamine N-methyltransferase from monkey adrenal glands

Biological Species/NCBI Monkey ID

62 of 143

Organs/Tissues

Gland: adrenal

Substance RN

4357479View in Reaxys

Measurement Parameter

Qualitative

Measurement Object

log A

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lethal dose of the compound in rabbit after intramuscular administration

Biological Species/NCBI rabbit ID Substance RN

4357479View in Reaxys

Substance Route of Adm.

intramuscular administration

Qualitative Results

320

Measurement Parameter

LD50

Unit

mg/kg

Measurement Object

Lethal dose

Quantitative value

320

MARSHALL R. WARREN; HAROLD W. WERNER; The Journal of pharmacology and experimental therapeutics; vol. 86; (1946); p. 284, View in Reaxys 63 of 143

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lethal dose of the compound in mouse after intraperitoneal administration

Biological Species/NCBI Mus musculus ID Substance RN

4357479View in Reaxys

Substance Route of Adm.

intraperitoneal administration

Qualitative Results

428

Measurement Parameter

LD50

Unit

mg/kg

Quantitative value

428

SIEGMUND; NASH; GRANGER; The Journal of pharmacology and experimental therapeutics; vol. 92; nb. 3; (1948); p. 207 - 213, View in Reaxys 64 of 143

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lethal dose of the compound in rabbit after subcutaneous administration

Biological Species/NCBI rabbit ID Substance RN

4357479View in Reaxys

Qualitative Results

255

Measurement Parameter

LD50

Unit

mg/kg

Quantitative value

255

31/59

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MARSHALL R. WARREN; HAROLD W. WERNER; The Journal of pharmacology and experimental therapeutics; vol. 86; (1946); p. 284, View in Reaxys 65 of 143

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lethal dose of the compound in rat after intraperitoneal administration

Biological Species/NCBI Rattus norvegicus ID Substance RN

4357479View in Reaxys

Qualitative Results

160

Measurement Parameter

LD50

Unit

mg/kg

Quantitative value

160

MARSHALL R. WARREN; HAROLD W. WERNER; The Journal of pharmacology and experimental therapeutics; vol. 86; (1946); p. 284, View in Reaxys 66 of 143

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lowest lethal dose of the compound in guinea pig after subcutaneous administration

Biological Species/NCBI guinea pig ID Substance RN

4357479View in Reaxys

Substance Route of Adm.

subcutaneous administration

Qualitative Results

600

Measurement Parameter

LDLo

Unit

mg/kg

Measurement Object

Lowest lethal dose

Quantitative value

600

Journal of the American Chemical Society; vol. 52; (1930); p. 3317, View in Reaxys 67 of 143

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lethal dose of the compound in rabbit after intravenous administration

Biological Species/NCBI rabbit ID Substance RN

4357479View in Reaxys

Qualitative Results

Measurement Parameter

LD50

Unit

mg/kg

Quantitative value

MARSHALL R. WARREN; HAROLD W. WERNER; The Journal of pharmacology and experimental therapeutics; vol. 86; (1946); p. 284, View in Reaxys 68 of 143

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lowest lethal dose of the compound in rat after subcutaneous administration

Biological Species/NCBI Rattus norvegicus ID Substance RN

4357479View in Reaxys

Substance Route of Adm.

subcutaneous administration

32/59

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Qualitative Results

Measurement Parameter

LDLo

Unit

mg/kg

Measurement Object

Lowest lethal dose

Quantitative value

The Journal of pharmacology and experimental therapeutics; vol. 71; (1941); p. 62, View in Reaxys 69 of 143

Bioassay Category

Toxicity/Safety Pharmacology

Bioassay Details

Lethal dose of the compound in mouse after subcutaneous administration

Biological Species/NCBI Mus musculus ID Substance RN

4357479View in Reaxys

Substance Route of Adm.

subcutaneous administration

Measurement Parameter

LD50

Unit

mg/kg

Quantitative value

600

MARSHALL R. WARREN; HAROLD W. WERNER; The Journal of pharmacology and experimental therapeutics; vol. 86; (1946); p. 280, View in Reaxys 70 of 143

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Tested for intrinsic effect at the concentration of 3X10e-6M

Biological Species/NCBI Rattus norvegicus ID Substance RN

4357479View in Reaxys

Measurement Parameter

IA (%)

Unit

Qualitative value

Quantitative value

Miller; Hsu; Salman; Patil; Journal of Medicinal Chemistry; vol. 19; nb. 1; (1976); p. 180 - 184, View in Reaxys 71 of 143

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Ability to potentiate the action of (-)norepinephrine in rat vas deference at the dose of 3X10e-6 M

Biological Species/NCBI Rattus norvegicus ID Organs/Tissues

Vas deferens

Substance RN

4357479View in Reaxys

Measurement Parameter

IA (%)

Unit

Qualitative value

Quantitative value

Miller; Hsu; Salman; Patil; Journal of Medicinal Chemistry; vol. 19; nb. 1; (1976); p. 180 - 184, View in Reaxys 72 of 143

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

33/59

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Bioassay Details

Inhibition of binding of amphetamine-3H to Anti-methamphetamine serum

Substance RN

4357479View in Reaxys

Measurement Parameter

IC50

Unit

Qualitative value

Quantitative value

Concomitants: Compound name

[3H]Amphetamine

Concomitants: Compound role

RAD

Faraj; Israili; Kight; Smissman; Pazdernik; Journal of medicinal chemistry; vol. 19; nb. 1; (1976); p. 20 - 25, View in Reaxys 73 of 143

Bioassay Category

Pharmacokinetic

Bioassay Details

Peak plasma concentration of the compound in human upon oral administration

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

0.08

Measurement Parameter

Cmax

Unit

µg/mL

Quantitative value

0.08

Clarke's Analysis of Drugs and Poisons, View in Reaxys 74 of 143

Bioassay Category

Metabolism/Transport

Bioassay Details

Plasma half life of the compound

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

Measurement Parameter

t1/2 el

Unit

hour

Measurement Object

Half Life

Quantitative value

Clarke's Analysis of Drugs and Poisons, View in Reaxys 75 of 143

Bioassay Category

Pharmacokinetic

Bioassay Details

Urinary excretion of unchanged drug after 24 h of oral administration in human

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

Measurement Parameter

Ue (%)

Unit

Quantitative value

34/59

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Clarke's Analysis of Drugs and Poisons, View in Reaxys 76 of 143

Bioassay Category

Pharmacokinetic

Bioassay Details

Time to reach peak plasma concentration of the compound in human upon oral administration

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

Measurement Parameter

Tmax

Unit

hour

Quantitative value

Clarke's Analysis of Drugs and Poisons, View in Reaxys 77 of 143

Target Name

5-hydroxytryptamine receptor [Rattus norvegicus]

Target Synonyms

5-hydroxytryptamine receptor

Target, Subunit, Species 5-hydroxytryptamine receptor [Rattus norvegicus] Target Mutant/Chimera Details

5-hydroxytryptamine receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Affinity against 5-hydroxytryptamine receptor in rat fundus model; not determined

Biological Species/NCBI Rattus norvegicus ID

78 of 143

Substance RN

4357479View in Reaxys

Measurement Parameter

pA2

Qualitative value

Target Name

Alpha-2A adrenergic receptor [Rattus norvegicus]

Target Synonyms

adra2a; alpha-2a adrenergic receptor; alpha-2a adrenoceptor; alpha-2a adrenoreceptor; alpha-2aar; alpha-2d adrenergic receptor; ca2-47

Target Uniprot ID

p22909

Target, Subunit, Species Alpha-2A adrenergic receptor [Rattus norvegicus] Target Mutant/Chimera Details

Alpha-2A adrenergic receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Functional agonism of the compounds to constrict tissue containing the alpha-2A adrenoceptor in rat prostatic vas deferens

Biological Species/NCBI Rattus norvegicus ID Organs/Tissues

Vas deferens

Substance RN

4357479View in Reaxys

Measurement Parameter

35/59

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Quantitative value

5.17

Measurement pX

5.17

Altenbach, Robert J.; Khilevich, Albert; Kolasa, Teodozyj; Rohde, Jeffrey J.; Bhatia, Pramila A.; Patel, Meena V.; Searle, Xenia B.; Yang, Fan; Bunnelle, William H.; Tietje, Karin; Bayburt, Erol K.; Carroll, William A.; Meyer, Michael D.; Henry, Rodger; Buckner, Steven A.; Kuk, Jane; Daza, Anthony V.; Milicic, Ivan V.; Cain, John C.; Kang, Chae H.; Ireland, Lynne M.; Carr, Tracy L.; Miller, Thomas R.; Hancock, Arthur A.; Nakane, Masaki; Esbenshade, Timothy A.; Brune, Michael E.; O'Neill, Alyssa B.; Gauvin, Donna M.; Katwala, Sweta P.; Holladay, Mark W.; Brioni, Jorge D.; Sullivan, James P.; Journal of Medicinal Chemistry; vol. 47; nb. 12; (2004); p. 3220 - 3235, View in Reaxys 79 of 143

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Uroselectivity was determined by measuring effective dose required for 5 mmHg increase of intraurethral pressure (IUP) in vivo in dog

Biological Species/NCBI dog ID Substance RN

4357479View in Reaxys

Measurement Parameter

Activity

Unit

nM/kg

Measurement Object

Change in ED5

Qualitative value

Quantitative value

1100

Target Name

Alpha-1B adrenergic receptor [Rattus norvegicus]

Target Synonyms

adra1b; alpha-1b adrenergic receptor; alpha-1b adrenoceptor; alpha-1b adrenoreceptor

Target Uniprot ID

p15823

Target, Subunit, Species Alpha-1B adrenergic receptor [Rattus norvegicus] Target Mutant/Chimera Details

Alpha-1B adrenergic receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Functional agonism of the compounds to constrict tissue containing the alpha-1B adrenergic receptor in rat spleen

Biological Species/NCBI Rattus norvegicus ID Organs/Tissues

Spleen

Substance RN

4357479View in Reaxys

Measurement Parameter

Quantitative value

3.55

Measurement pX

3.55

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day, Mark W.; Brioni, Jorge D.; Sullivan, James P.; Journal of Medicinal Chemistry; vol. 47; nb. 12; (2004); p. 3220 - 3235, View in Reaxys 81 of 143

Target Name

Alpha-2B adrenergic receptor [Rattus norvegicus]

Target Synonyms

adra2b; alpha-2b adrenergic receptor; alpha-2b adrenoceptor; alpha-2b adrenoreceptor; alpha-2bar

Target Uniprot ID

p19328

Target, Subunit, Species Alpha-2B adrenergic receptor [Rattus norvegicus] Target Mutant/Chimera Details

Alpha-2B adrenergic receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Selectivity is ratio of pKi (binding affinity) of Alpha-2B adrenergic receptor to that of Alpha-1A adrenergic receptor

Biological Species/NCBI Rattus norvegicus ID Substance RN

4357479View in Reaxys

Measurement Parameter

Qualitative

Qualitative value

Not Published

Target Name

Alpha-1A adrenergic receptor [Rattus norvegicus]

Target Synonyms

adra1a (alpha-1a adrenergic receptor); adra1c; alpha-1a adrenergic receptor; alpha-1a adrenoceptor; alpha-1a adrenoreceptor; alpha-1c adrenergic receptor

Target Uniprot ID

p43140

Target, Subunit, Species Alpha-1A adrenergic receptor [Rattus norvegicus] Target Mutant/Chimera Details

Alpha-1A adrenergic receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

In vitro binding affinity of the compound towards rat submaxillary gland alpha-1A adrenergic receptor was measured by radioligand binding assay

Biological Species/NCBI Rattus norvegicus ID Organs/Tissues

Gland: submandibular

Substance RN

4357479View in Reaxys

Measurement Parameter

pKi

Quantitative value

5.01

Measurement pX

5.01

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Target Name

Alpha-2A adrenergic receptor [Rattus norvegicus]

Target Synonyms

adra2a; alpha-2a adrenergic receptor; alpha-2a adrenoceptor; alpha-2a adrenoreceptor; alpha-2aar; alpha-2d adrenergic receptor; ca2-47

Target Uniprot ID

p22909

Target, Subunit, Species Alpha-2A adrenergic receptor [Rattus norvegicus] Target Mutant/Chimera Details

Alpha-2A adrenergic receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Selectivity is ratio of efficacy of Alpha-2A adrenergic receptor to that of Alpha-1A adrenergic receptor

Biological Species/NCBI Rattus norvegicus ID Substance RN

4357479View in Reaxys

Measurement Parameter

Qualitative

Qualitative value

Not Published

Target Name

Alpha-1D adrenergic receptor [Rattus norvegicus]

Target Synonyms

adra1a (alpha-1d adrenergic receptor); adra1d; alpha-1a adrenergic receptor (alpha-1d adrenergic receptor); alpha-1d adrenergic receptor; alpha-1d adrenoceptor; alpha-1d adrenoreceptor; ra42

Target Uniprot ID

p23944

Target, Subunit, Species Alpha-1D adrenergic receptor [Rattus norvegicus] Target Mutant/Chimera Details

Alpha-1D adrenergic receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Functional agonism of the compounds to constrict tissue containing the alpha-1D adrenergic receptor in rat aorta

Biological Species/NCBI Rattus norvegicus ID Cells/Cell Lines

Aortic cell

Substance RN

4357479View in Reaxys

Measurement Parameter

38/59

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Quantitative value

4.12

Measurement pX

4.12

Target Name

Alpha-1B adrenergic receptor [hamster]

Target Synonyms

alpha-1b adrenergic receptor

Target, Subunit, Species Alpha-1B adrenergic receptor [hamster] Target Mutant/Chimera Details

Alpha-1B adrenergic receptor [hamster]:Wild

Target Species (Bioactivity)

hamster

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

In vitro binding affinity of the compound towards hamster clone alpha-1B adrenergic receptor was measured by radioligand binding assay

Biological Species/NCBI hamster ID Substance RN

4357479View in Reaxys

Measurement Parameter

pKi

Quantitative value

5.02

Measurement pX

5.02

Target Name

Alpha-1D adrenergic receptor [Rattus norvegicus]

Target Synonyms

adra1a (alpha-1d adrenergic receptor); adra1d; alpha-1a adrenergic receptor (alpha-1d adrenergic receptor); alpha-1d adrenergic receptor; alpha-1d adrenoceptor; alpha-1d adrenoreceptor; ra42

Target Uniprot ID

p23944

Target, Subunit, Species Alpha-1D adrenergic receptor [Rattus norvegicus] Target Mutant/Chimera Details

Alpha-1D adrenergic receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Selectivity is ratio of pKi (binding affinity) of Alpha-1D adrenergic receptor to that of Alpha-1A adrenergic receptor

Biological Species/NCBI Rattus norvegicus ID

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Substance RN

4357479View in Reaxys

Measurement Parameter

Qualitative

Qualitative value

Not Published

Target Name

Alpha-1B adrenergic receptor [Rattus norvegicus]

Target Synonyms

adra1b; alpha-1b adrenergic receptor; alpha-1b adrenoceptor; alpha-1b adrenoreceptor

Target Uniprot ID

p15823

Target, Subunit, Species Alpha-1B adrenergic receptor [Rattus norvegicus] Target Mutant/Chimera Details

Alpha-1B adrenergic receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Selectivity is ratio of efficacy of Alpha-1B adrenergic receptor to that of Alpha-1A adrenergic receptor

Biological Species/NCBI Rattus norvegicus ID Substance RN

4357479View in Reaxys

Measurement Parameter

Qualitative

Qualitative value

Not Published

Target Name

Alpha-1D adrenergic receptor [Rattus norvegicus]

Target Synonyms

adra1a (alpha-1d adrenergic receptor); adra1d; alpha-1a adrenergic receptor (alpha-1d adrenergic receptor); alpha-1d adrenergic receptor; alpha-1d adrenoceptor; alpha-1d adrenoreceptor; ra42

Target Uniprot ID

p23944

Target, Subunit, Species Alpha-1D adrenergic receptor [Rattus norvegicus] Target Mutant/Chimera Details

Alpha-1D adrenergic receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

In vitro binding affinity of the compound towards rat clone alpha-1D adrenergic receptor was measured by radioligand binding assay

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Biological Species/NCBI Rattus norvegicus ID Substance RN

4357479View in Reaxys

Measurement Parameter

pKi

Quantitative value

5.07

Measurement pX

5.07

Target Name

Alpha-2A adrenergic receptor [human]

Target Synonyms

adra2a; adra2r; adrar; alpha-2 adrenergic receptor subtype c10; alpha-2a adrenergic receptor; alpha-2a adrenoceptor; alpha-2a adrenoreceptor; alpha-2aar

Target Uniprot ID

p08913

Target, Subunit, Species Alpha-2A adrenergic receptor [human] Target Mutant/Chimera Details

Alpha-2A adrenergic receptor [human]:Wild

Target Species (Bioactivity)

human

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Measurement Parameter

pKi

Quantitative value

6.56

Measurement pX

6.56

Target Name

Alpha-2A adrenergic receptor [Rattus norvegicus]

Target Synonyms

adra2a; alpha-2a adrenergic receptor; alpha-2a adrenoceptor; alpha-2a adrenoreceptor; alpha-2aar; alpha-2d adrenergic receptor; ca2-47

Target Uniprot ID

p22909

Target, Subunit, Species Alpha-2A adrenergic receptor [Rattus norvegicus] Target Mutant/Chimera Details

Alpha-2A adrenergic receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Bioassay Category

In Vitro (Efficacy)

41/59

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Bioassay Details

Efficacy of the compound relative to phenylephrine (PE) to constrict tissue containing the alpha-2A adrenergic receptor in rat prostatic vas deferens

Biological Species/NCBI Rattus norvegicus ID Organs/Tissues

Vas deferens

Substance RN

4357479View in Reaxys

Measurement Parameter

Activity

Unit

Measurement Object

Efficacy

Qualitative value

Quantitative value

Target Name

Alpha-2A adrenergic receptor [Rattus norvegicus]

Target Synonyms

adra2a; alpha-2a adrenergic receptor; alpha-2a adrenoceptor; alpha-2a adrenoreceptor; alpha-2aar; alpha-2d adrenergic receptor; ca2-47

Target Uniprot ID

p22909

Target, Subunit, Species Alpha-2A adrenergic receptor [Rattus norvegicus] Target Mutant/Chimera Details

Alpha-2A adrenergic receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Selectivity is ratio of pKi (binding affinity) of Alpha-2A adrenergic receptor to that of Alpha-1A adrenergic receptor

Biological Species/NCBI Rattus norvegicus ID Substance RN

4357479View in Reaxys

Measurement Parameter

Qualitative

Qualitative value

Not Published

Target Name

Alpha-1A adrenergic receptor [rabbit]

Target Synonyms

alpha-1a adrenergic receptor

Target, Subunit, Species Alpha-1A adrenergic receptor [rabbit] Target Mutant/Chimera Details

Alpha-1A adrenergic receptor [rabbit]:Wild

42/59

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Target Species (Bioactivity)

rabbit

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Functional agonism of the compounds to constrict tissue containing the alpha-1A adrenergic receptor in rabbit urethra

Biological Species/NCBI rabbit ID Organs/Tissues

Urethra

Substance RN

4357479View in Reaxys

Measurement Parameter

Quantitative value

3.63

Measurement pX

3.63

Target Name

Alpha-1B adrenergic receptor [hamster]

Target Synonyms

alpha-1b adrenergic receptor

Target, Subunit, Species Alpha-1B adrenergic receptor [hamster] Target Mutant/Chimera Details

Alpha-1B adrenergic receptor [hamster]:Wild

Target Species (Bioactivity)

hamster

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Selectivity is ratio of pKi (binding affinity) of Alpha-1B adrenergic receptor to that of Alpha-1A adrenergic receptor

Biological Species/NCBI hamster ID Substance RN

4357479View in Reaxys

Measurement Parameter

Qualitative

Qualitative value

Not Published

Target Name

Alpha-1B adrenergic receptor [Rattus norvegicus]

Target Synonyms

adra1b; alpha-1b adrenergic receptor; alpha-1b adrenoceptor; alpha-1b adrenoreceptor

Target Uniprot ID

p15823

Target, Subunit, Species Alpha-1B adrenergic receptor [Rattus norvegicus] Target Mutant/Chimera Details

Alpha-1B adrenergic receptor [Rattus norvegicus]:Wild

43/59

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Target Species (Bioactivity)

Rattus norvegicus

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Efficacy of the compound relative to phenylephrine (PE) constrict tissue containing the alpha-1B adrenergic receptor in rat spleen

Biological Species/NCBI Rattus norvegicus ID Organs/Tissues

Spleen

Substance RN

4357479View in Reaxys

Measurement Parameter

Activity

Unit

Measurement Object

Efficacy

Qualitative value

Quantitative value

Target Name

Alpha-1D adrenergic receptor [Rattus norvegicus]

Target Synonyms

adra1a (alpha-1d adrenergic receptor); adra1d; alpha-1a adrenergic receptor (alpha-1d adrenergic receptor); alpha-1d adrenergic receptor; alpha-1d adrenoceptor; alpha-1d adrenoreceptor; ra42

Target Uniprot ID

p23944

Target, Subunit, Species Alpha-1D adrenergic receptor [Rattus norvegicus] Target Mutant/Chimera Details

Alpha-1D adrenergic receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Selectivity is ratio of efficacy of Alpha-1D adrenergic receptor to that of Alpha-1A adrenergic receptor

Biological Species/NCBI Rattus norvegicus ID Substance RN

4357479View in Reaxys

Measurement Parameter

Qualitative

Qualitative value

Not Published

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Ratio of IUP ED delta5 to that of MAP ED delta20

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Substance RN

4357479View in Reaxys

Measurement Parameter

Ratio

Quantitative value

0.4

Target Name

Alpha-1A adrenergic receptor [rabbit]

Target Synonyms

alpha-1a adrenergic receptor

Target, Subunit, Species Alpha-1A adrenergic receptor [rabbit] Target Mutant/Chimera Details

Alpha-1A adrenergic receptor [rabbit]:Wild

Target Species (Bioactivity)

rabbit

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Efficacy of the compound relative to phenylephrine (PE) to constrict tissue containing the alpha-1A adrenergic receptor in rabbit urethra

Biological Species/NCBI rabbit ID Organs/Tissues

Urethra

Substance RN

4357479View in Reaxys

Measurement Parameter

Activity

Unit

Measurement Object

Efficacy

Qualitative value

Quantitative value

Target Name

Alpha-2B adrenergic receptor [Rattus norvegicus]

Target Synonyms

adra2b; alpha-2b adrenergic receptor; alpha-2b adrenoceptor; alpha-2b adrenoreceptor; alpha-2bar

Target Uniprot ID

p19328

Target, Subunit, Species Alpha-2B adrenergic receptor [Rattus norvegicus] Target Mutant/Chimera Details

Alpha-2B adrenergic receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

45/59

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Bioassay Details

In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay

Biological Species/NCBI Rattus norvegicus ID Organs/Tissues

Lung

Substance RN

4357479View in Reaxys

Measurement Parameter

pKi

Quantitative value

6.58

Measurement pX

6.58

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Uroselectivity was determined by measuring effective dose required for 20 mmHg increase of mean arterial pressure (MAP) in vivo in dog

Biological Species/NCBI dog ID Substance RN

4357479View in Reaxys

Measurement Parameter

Activity

Unit

nM/kg

Measurement Object

Change in ED20

Qualitative value

Quantitative value

330

Alpha-1D adrenergic receptor [Rattus norvegicus]

Target Synonyms

adra1a (alpha-1d adrenergic receptor); adra1d; alpha-1a adrenergic receptor (alpha-1d adrenergic receptor); alpha-1d adrenergic receptor; alpha-1d adrenoceptor; alpha-1d adrenoreceptor; ra42

Target Uniprot ID

p23944

Target, Subunit, Species Alpha-1D adrenergic receptor [Rattus norvegicus] Target Mutant/Chimera Details

Alpha-1D adrenergic receptor [Rattus norvegicus]:Wild

Target Species (Bioactivity)

Rattus norvegicus

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Efficacy of the compound relative to phenylephrine (PE) constrict tissue containing the alpha-1D adrenergic receptor in rat aorta

Biological Species/NCBI Rattus norvegicus ID Cells/Cell Lines

Aortic cell

46/59

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Substance RN

4357479View in Reaxys

Measurement Parameter

Activity

Unit

Measurement Object

Efficacy

Qualitative value

Quantitative value

Toxicity/Safety Pharmacology Lethal dose of the compound in mouse after oral administration

Biological Species/NCBI Mus musculus ID Substance RN

4357479View in Reaxys

Substance Route of Adm.

oral administration

Qualitative Results

150

Measurement Parameter

LD50

Unit

mg/kg

Quantitative value

150

BOISSIER; SIMON; FICHELLE; HERVOUET; Thérapie; vol. 20; (1965); p. 297 - 309, View in Reaxys 102 of 143 Bioassay Category Bioassay Details

Toxicity/Safety Pharmacology Lowest lethal dose of the compound in mouse after intravenous administration

Biological Species/NCBI Mus musculus ID Substance RN

4357479View in Reaxys

Substance Route of Adm.

intravenous administration

Qualitative Results

275

Measurement Parameter

LDLo

Unit

mg/kg

Measurement Object

Lowest lethal dose

Quantitative value

275

Quarterly journal of pharmacy and pharmacology; vol. 9; (1936); p. 203, View in Reaxys 103 of 143 Bioassay Category Bioassay Details

Pharmacokinetic For oral doses

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

65 ± 10

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Measurement Parameter

Excretion

Unit

Quantitative value

Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th ed., 1996; (1996), View in Reaxys 104 of 143 Bioassay Category Bioassay Details

Metabolism/Transport CL/F,Varea/F and half-life for multiple dosing studies

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

4.1 ± 0.9

Measurement Parameter

Unit

L/kg

Quantitative value

4.1

Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th ed., 1996; (1996), View in Reaxys 105 of 143 Bioassay Category Bioassay Details

Toxicity/Safety Pharmacology Dose given intraperitonially causes marked potentiation of the hepatic necrosis induced by acetaminophen in the rat

Biological Species/NCBI Rattus norvegicus ID Substance RN

4357479View in Reaxys

Qualitative Results

200

Measurement Parameter

Unit

mg/kg

Quantitative value

200

Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th ed., 1996; (1996), View in Reaxys 106 of 143 Bioassay Category Bioassay Details

Metabolism/Transport CL/F,Varea/F and half-life for multiple dosing studies

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

4.7 ± 0.4

Measurement Parameter

t1/2 el

Unit

hour

Quantitative value

4.7

Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th ed., 1996; (1996), View in Reaxys 107 of 143 Bioassay Category Bioassay Details

Pharmacokinetic Oral availability

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Substance Route of Adm.

oral administration

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Qualitative Results

>70

Measurement Parameter

F(%)

Unit

Measurement Object

Bioavailability

Quantitative value

Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th ed., 1996; (1996), View in Reaxys 108 of 143 Bioassay Category Bioassay Details

Pharmacokinetic Peak plasma concentrations attained after administartion

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

1-2

Measurement Parameter

Tmax

Unit

hour

Quantitative value

1.5

Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th ed., 1996; (1996), View in Reaxys 109 of 143 Bioassay Category Bioassay Details

Metabolism/Transport CL/F,Varea/F and half-life for multiple dosing studies

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

10 ± 3

Measurement Parameter

Unit

mL/min/kg

Quantitative value

Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th ed., 1996; (1996), View in Reaxys 110 of 143

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Intrinsic activity calculated as ratio between the maximal response elicited by the compound and (-)norepinephrine

Biological Species/NCBI Rattus norvegicus ID Organs/Tissues

Vas deferens

Substance RN

4357479View in Reaxys

Measurement Parameter

IA (%)

Unit

Measurement Object

Maximal response

Quantitative value

0.2

Antonio DELGADO; David MAULEON; Gloria ROSELL; Ricardo GRANADOS; European journal of medicinal chemistry; vol. 23; (1988); p. 31 - 38, View in Reaxys 111 of 143

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Tested for beta1-blocking activity in isolated guinea pig left atria

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Biological Species/NCBI guinea pig ID Substance RN

4357479View in Reaxys

Measurement Parameter

pA2

Measurement Object

beta1-blocking activity

Quantitative value

6.56

Measurement pX

6.56

Antonio DELGADO; David MAULEON; Gloria ROSELL; Ricardo GRANADOS; European journal of medicinal chemistry; vol. 23; (1988); p. 31 - 38, View in Reaxys 112 of 143

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Tested for beta2-blocking activity in isolated guinea pig tracheal chains

Biological Species/NCBI guinea pig ID Substance RN

4357479View in Reaxys

Measurement Parameter

pA2

Measurement Object

beta2-blocking activity

Quantitative value

5.43

Measurement pX

5.43

Antonio DELGADO; David MAULEON; Gloria ROSELL; Ricardo GRANADOS; European journal of medicinal chemistry; vol. 23; (1988); p. 31 - 38, View in Reaxys 113 of 143

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Effective concentration required to show alpha-agonistic activity in isolated rat vas deferens

Biological Species/NCBI Rattus norvegicus ID Organs/Tissues

Vas deferens

Substance RN

4357479View in Reaxys

Measurement Parameter

EC50

Unit

Measurement Object

Alpha-agonistic activity

Qualitative value

Quantitative value

4.16E-05

Measurement pX

4.38

Antonio DELGADO; David MAULEON; Gloria ROSELL; Ricardo GRANADOS; European journal of medicinal chemistry; vol. 23; (1988); p. 31 - 38, View in Reaxys 114 of 143

Target Name

Phenylethanolamine N-methyltransferase [taurine cattle]

Target Synonyms

noradrenaline n-methyltransferase; phenylethanolamine n-methyltransferase; pnmt; pnmtase

Target Uniprot ID

p10938

Target, Subunit, Species Phenylethanolamine N-methyltransferase [taurine cattle] Target Mutant/Chimera Details

Phenylethanolamine N-methyltransferase [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

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Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

In vitro binding affinity of compound towards bovine adrenal Phenylethanolamine N-Methyltransferase

Biological Species/NCBI taurine cattle ID Substance RN

4357479View in Reaxys

Measurement Parameter

Unit

Qualitative value

Quantitative value

2440000

Measurement pX

2.61

Grunewald; Ye; Journal of Medicinal Chemistry; vol. 31; nb. 10; (1988); p. 1984 - 1986, View in Reaxys 115 of 143

Target Name

Phenylethanolamine N-methyltransferase [taurine cattle]

Target Synonyms

noradrenaline n-methyltransferase; phenylethanolamine n-methyltransferase; pnmt; pnmtase

Target Uniprot ID

p10938

Target, Subunit, Species Phenylethanolamine N-methyltransferase [taurine cattle] Target Mutant/Chimera Details

Phenylethanolamine N-methyltransferase [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

In vitro binding affinity of compound towards bovine adrenal Phenylethanolamine N-Methyltransferase

Biological Species/NCBI taurine cattle ID Substance RN

4357479View in Reaxys

Measurement Parameter

Unit

Qualitative value

Quantitative value

2980000

Measurement pX

2.53

Grunewald; Ye; Journal of Medicinal Chemistry; vol. 31; nb. 10; (1988); p. 1984 - 1986, View in Reaxys 116 of 143

Target Name

Phenylethanolamine N-methyltransferase [taurine cattle]

Target Synonyms

noradrenaline n-methyltransferase; phenylethanolamine n-methyltransferase; pnmt; pnmtase

Target Uniprot ID

p10938

Target, Subunit, Species Phenylethanolamine N-methyltransferase [taurine cattle] Target Mutant/Chimera Details

Phenylethanolamine N-methyltransferase [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

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Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

In vitro binding affinity of compound towards bovine adrenal Phenylethanolamine N-Methyltransferase

Biological Species/NCBI taurine cattle ID Substance RN

4357479View in Reaxys

Measurement Parameter

Unit

Qualitative value

Quantitative value

3700000

Measurement pX

2.43

Grunewald; Ye; Journal of Medicinal Chemistry; vol. 31; nb. 10; (1988); p. 1984 - 1986, View in Reaxys 117 of 143

Target Name

Phenylethanolamine N-methyltransferase [taurine cattle]

Target Synonyms

noradrenaline n-methyltransferase; phenylethanolamine n-methyltransferase; pnmt; pnmtase

Target Uniprot ID

p10938

Target, Subunit, Species Phenylethanolamine N-methyltransferase [taurine cattle] Target Mutant/Chimera Details

Phenylethanolamine N-methyltransferase [taurine cattle]:Wild

Target Species (Bioactivity)

taurine cattle

Substance Action on Target

Radioligand (/ligand)

Bioassay Category

In Vitro (Efficacy)

Bioassay Details

In vitro binding affinity of compound towards bovine adrenal Phenylethanolamine N-Methyltransferase

Biological Species/NCBI taurine cattle ID Substance RN

4357479View in Reaxys

Measurement Parameter

Unit

Qualitative value

Quantitative value

1310000

Measurement pX

2.88

Grunewald; Ye; Journal of Medicinal Chemistry; vol. 31; nb. 10; (1988); p. 1984 - 1986, View in Reaxys 118 of 143

Bioassay Category

In Vivo (Animal models)

Bioassay Details

Effect on blood pressure was determined in anaesthetized dog at 3x10e-7 moles/Kg administered intravenously; Increase in blood pressure

Biological Species/NCBI dog ID Substance RN

4357479View in Reaxys

Substance Route of Adm.

intravenous administration

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Measurement Parameter

Activity

Measurement Object

Blood Pressure

Qualitative value

ALLES; FAIRCHILD; JENSEN; Journal of medicinal and pharmaceutical chemistry; vol. 3; (1961); p. 323 - 352, View in Reaxys 119 of 143

Bioassay Category

In Vivo (Animal models)

Bioassay Details

Motor activity was evaluated in mice at a dose of 40 mg/Kg administered subcutaneously; Increased activity

Biological Species/NCBI Mus musculus ID Substance RN

4357479View in Reaxys

Substance Route of Adm.

subcutaneous administration

Measurement Parameter

Activity

Measurement Object

Motor activity

Qualitative value

ALLES; FAIRCHILD; JENSEN; Journal of medicinal and pharmaceutical chemistry; vol. 3; (1961); p. 323 - 352, View in Reaxys 120 of 143 Bioassay Category Bioassay Details

In Vivo (Animal models) Motor activity was evaluated in mice at a dose of 50mg/kg administered subcutaneously; Not active

Biological Species/NCBI Mus musculus ID Substance RN

4357479View in Reaxys

Substance Route of Adm.

subcutaneous administration

Measurement Parameter

Activity

Qualitative value

ALLES; FAIRCHILD; JENSEN; Journal of medicinal and pharmaceutical chemistry; vol. 3; (1961); p. 323 - 352, View in Reaxys 121 of 143 Bioassay Category Bioassay Details

In Vitro (Efficacy) Effect on respiration was determined in anaesthetized dog at 3x10e-7 moles/Kg administered intravenously; Increase in respiration

Biological Species/NCBI dog ID Substance RN

4357479View in Reaxys

Substance Route of Adm.

intravenous administration

Measurement Parameter

Activity

Measurement Object

Increase in respiration

Qualitative value

ALLES; FAIRCHILD; JENSEN; Journal of medicinal and pharmaceutical chemistry; vol. 3; (1961); p. 323 - 352, View in Reaxys 122 of 143 Bioassay Category Bioassay Details

In Vitro (Efficacy) Motor activity was evaluated in mice at a dose of 100mg/kg administered subcutaneously; Active

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Biological Species/NCBI Mus musculus ID Substance RN

4357479View in Reaxys

Substance Route of Adm.

subcutaneous administration

Measurement Parameter

Activity

Qualitative value

ALLES; FAIRCHILD; JENSEN; Journal of medicinal and pharmaceutical chemistry; vol. 3; (1961); p. 323 - 352, View in Reaxys 123 of 143 Bioassay Category Bioassay Details

In Vitro (Efficacy) Lag time in normal humans on day 1 upon single oral administration of Dexatrim controlled-release (CR) caplet

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Substance Route of Adm.

oral administration

Measurement Parameter

Tlag

Unit

hour

Measurement Object

Lag time

Qualitative value

Quantitative value

0.394

Shargel; Silverman; Cohen; Brisson; Dennis; Biopharmaceutics and Drug Disposition; vol. 11; nb. 7; (1990); p. 569 - 583, View in Reaxys 124 of 143 Bioassay Category Bioassay Details

Pharmacokinetic Time to reach Cmax in normal humans on day 1 upon single oral administration of Dexatrim controlled-release (CR) caplet

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

4.5 +/- 0.26

Measurement Parameter

Tmax

Unit

hour

Quantitative value

4.5

Shargel; Silverman; Cohen; Brisson; Dennis; Biopharmaceutics and Drug Disposition; vol. 11; nb. 7; (1990); p. 569 - 583, View in Reaxys 125 of 143 Bioassay Category Bioassay Details

Pharmacokinetic Mean area under concentration time curve in normal humans on day 1 upon oral administration of the solution 3 times a day

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

1.716 +/- 0.0903

Measurement Parameter

AUC

Unit

µg.h/mL

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Quantitative value

1.716

Shargel; Silverman; Cohen; Brisson; Dennis; Biopharmaceutics and Drug Disposition; vol. 11; nb. 7; (1990); p. 569 - 583, View in Reaxys 126 of 143 Bioassay Category Bioassay Details

Pharmacokinetic Maximum plasma concentration in normal humans on day 1 upon oral administration of the solution 3 times a day

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

0.126 +/- 0.0058

Measurement Parameter

Cmax

Unit

µg/mL

Quantitative value

0.126

Shargel; Silverman; Cohen; Brisson; Dennis; Biopharmaceutics and Drug Disposition; vol. 11; nb. 7; (1990); p. 569 - 583, View in Reaxys 127 of 143 Bioassay Category Bioassay Details

Pharmacokinetic Elimination half life in normal humans on day 1 upon oral administration of the solution 3 times a day

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Substance Route of Adm.

oral administration

Qualitative Results

3.73 +/- 1.21

Measurement Parameter

t1/2 el

Unit

hour

Quantitative value

3.73

Shargel; Silverman; Cohen; Brisson; Dennis; Biopharmaceutics and Drug Disposition; vol. 11; nb. 7; (1990); p. 569 - 583, View in Reaxys 128 of 143 Bioassay Category Bioassay Details

Pharmacokinetic Maximum plasma concentration in normal humans on day 1 upon single oral administration of Dexatrim controlled-release (CR) caplet

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

0.143 +/- 0.0135

Measurement Parameter

Cmax

Unit

µg/mL

Quantitative value

0.143

Shargel; Silverman; Cohen; Brisson; Dennis; Biopharmaceutics and Drug Disposition; vol. 11; nb. 7; (1990); p. 569 - 583, View in Reaxys 129 of 143 Bioassay Category Bioassay Details

Pharmacokinetic Maximum plasma concentration in normal humans on day 4 upon oral administration of the solution 3 times a day

Biological Species/NCBI Human ID

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Substance RN

4357479View in Reaxys

Qualitative Results

0.143 +/- 0.0087

Measurement Parameter

Cmax

Unit

µg/mL

Quantitative value

0.143

Shargel; Silverman; Cohen; Brisson; Dennis; Biopharmaceutics and Drug Disposition; vol. 11; nb. 7; (1990); p. 569 - 583, View in Reaxys 130 of 143 Bioassay Category Bioassay Details

Pharmacokinetic Mean area under concentration time curve at steady state in normal humans on day 4 upon single oral administration of Dexatrim controlled-release (CR) caplet

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

1.832 +/- 0.101

Measurement Parameter

AUC

Unit

µg.h/mL

Quantitative value

1.832

Shargel; Silverman; Cohen; Brisson; Dennis; Biopharmaceutics and Drug Disposition; vol. 11; nb. 7; (1990); p. 569 - 583, View in Reaxys 131 of 143 Bioassay Category Bioassay Details

Metabolism/Transport Absorption rate constant in normal humans on day 1 upon single oral administration of Dexatrim controlled-release (CR) caplet

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

0.488 +/- 0.182

Measurement Parameter

kabs

Unit

h-1

Quantitative value

0.488

Shargel; Silverman; Cohen; Brisson; Dennis; Biopharmaceutics and Drug Disposition; vol. 11; nb. 7; (1990); p. 569 - 583, View in Reaxys 132 of 143 Bioassay Category Bioassay Details

Metabolism/Transport Absorption rate constant in normal humans on day 1 upon oral administration of the solution 3 times a day

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

2.87 +/- 1.51

Measurement Parameter

kabs

Unit

h-1

Quantitative value

2.87

Shargel; Silverman; Cohen; Brisson; Dennis; Biopharmaceutics and Drug Disposition; vol. 11; nb. 7; (1990); p. 569 - 583, View in Reaxys 133 of 143 Bioassay Category

Pharmacokinetic

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Bioassay Details

Time to reach Cmax in normal humans on day 4 upon oral administration of the solution 3 times a day

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

1.33 +/- 0.09

Measurement Parameter

Tmax

Unit

hour

Quantitative value

1.33

Shargel; Silverman; Cohen; Brisson; Dennis; Biopharmaceutics and Drug Disposition; vol. 11; nb. 7; (1990); p. 569 - 583, View in Reaxys 134 of 143 Bioassay Category Bioassay Details

Pharmacokinetic Time to reach Cmax in normal humans on day 1 upon oral administration of the solution 3 times a day

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

1.25 +/- 0.08

Measurement Parameter

Tmax

Unit

hour

Quantitative value

1.25

Shargel; Silverman; Cohen; Brisson; Dennis; Biopharmaceutics and Drug Disposition; vol. 11; nb. 7; (1990); p. 569 - 583, View in Reaxys 135 of 143 Bioassay Category Bioassay Details

Pharmacokinetic Time to reach Cmax in normal humans on day 4 upon single oral administration of Dexatrim controlled-release (CR) caplet

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

4.17 +/- 0.17

Measurement Parameter

Tmax

Unit

hour

Quantitative value

4.17

Shargel; Silverman; Cohen; Brisson; Dennis; Biopharmaceutics and Drug Disposition; vol. 11; nb. 7; (1990); p. 569 - 583, View in Reaxys 136 of 143 Bioassay Category Bioassay Details

Pharmacokinetic Elimination half life in normal humans on day 1 upon single oral administration of Dexatrim controlled-release (CR) caplet

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Substance Route of Adm.

oral administration

Qualitative Results

5.84 +/- 1.66

Measurement Parameter

t1/2 el

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Unit

hour

Quantitative value

5.84

Shargel; Silverman; Cohen; Brisson; Dennis; Biopharmaceutics and Drug Disposition; vol. 11; nb. 7; (1990); p. 569 - 583, View in Reaxys 137 of 143 Bioassay Category Bioassay Details

In Vivo (Animal models) Lag time in normal humans on day 1 upon oral administration of the solution 3 times a day

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Substance Route of Adm.

oral administration

Measurement Parameter

Tlag

Unit

hour

Measurement Object

Lag time

Qualitative value

Quantitative value

0.325

Shargel; Silverman; Cohen; Brisson; Dennis; Biopharmaceutics and Drug Disposition; vol. 11; nb. 7; (1990); p. 569 - 583, View in Reaxys 138 of 143 Bioassay Category Bioassay Details

Pharmacokinetic Mean area under concentration time curve at steady state in normal humans on day 4 upon oral administration of the solution 3 times a day

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

2.014 +/- 0.116

Measurement Parameter

AUC

Unit

µg.h/mL

Quantitative value

2.014

Shargel; Silverman; Cohen; Brisson; Dennis; Biopharmaceutics and Drug Disposition; vol. 11; nb. 7; (1990); p. 569 - 583, View in Reaxys 139 of 143 Bioassay Category Bioassay Details

Pharmacokinetic Maximum plasma concentration in normal humans on day 4 upon single oral administration of Dexatrim controlled-release (CR) caplet

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

0.151 +/- 0.0065

Measurement Parameter

Cmax

Unit

µg/mL

Quantitative value

0.151

Shargel; Silverman; Cohen; Brisson; Dennis; Biopharmaceutics and Drug Disposition; vol. 11; nb. 7; (1990); p. 569 - 583, View in Reaxys 140 of 143 Bioassay Category Bioassay Details

Pharmacokinetic Mean area under concentration time curve in normal humans on day 1 upon single oral administration of Dexatrim controlled-release (CR) caplet

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Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

1.651 +/- 0.127

Measurement Parameter

AUC

Unit

µg.h/mL

Quantitative value

1.651

Shargel; Silverman; Cohen; Brisson; Dennis; Biopharmaceutics and Drug Disposition; vol. 11; nb. 7; (1990); p. 569 - 583, View in Reaxys 141 of 143 Bioassay Category Bioassay Details

In Vivo (Animal models) Chemorelease activity of compound was tested in mice heart by injecting norepinephrine-3H into tail vein of mice after sc administration of compound at 10 mg/kg

Biological Species/NCBI Mus musculus ID Substance RN

4357479View in Reaxys

Substance Route of Adm.

subcutaneous administration

Measurement Parameter

Unit

Measurement Object

Norepinephrine-3H release

Qualitative value

Quantitative value

Concomitants: Compound name

[3H]Norepinephrine

Concomitants: Compound role

RAD

Daly; Creveling; Witkop; Journal of medicinal chemistry; vol. 9; nb. 3; (1966); p. 273 - 280, View in Reaxys 142 of 143 Bioassay Category Bioassay Details

Pharmacokinetic Peak effect

Biological Species/NCBI Human ID Substance RN

4357479View in Reaxys

Qualitative Results

1-4

Measurement Parameter

Tmax

Unit

hour

Quantitative value

2.5

Daly; Creveling; Witkop; Journal of medicinal chemistry; vol. 9; nb. 3; (1966); p. 273 - 280, View in Reaxys 143 of 143 Bioassay Category

In Vitro (Efficacy)

Bioassay Details

Compound was tested for its ability to induce weight loss; weakly effective

Substance RN

4357479View in Reaxys

Measurement Parameter

Activity

Qualitative value

Donald R.Gehlert; David J. Goldstein; Philip A. Hipskind; Annual reports in medicinal chemistry; vol. 31; (1996); p. 201 - 210, View in Reaxys

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