Methanol (MeOH) by Asch

Query Query 1. Query

Results

Date

20863 substances in Reaxys

2016-05-10 04h:39m:14s (EST)

1 substances in Reaxys

2016-05-10 04h:39m:37s (EST)

Search as: As drawn 2. Query

(1. Query) AND itemno in (1)

1/42

2016-05-10 05:50:17

Reaxys ID 1098229 View in Reaxys

1/1 CAS Registry Number: 67-56-1 Chemical Name: methanol; methyl alcohol; MeOH Linear Structure Formula: HOCH3 Molecular Formula: CH4O Molecular Weight: 32.0422 Type of Substance: acyclic; Isotope or isotope containing compound InChI Key: OKKJLVBELUTLKV-UHFFFAOYSA-N Note:

Ecotoxicology (142) 1 of 142

Effect (Ecotoxicology)

embryotoxicity

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

orange-red strain medaka embryos (early blastodisc, stage 2) exposed to title comp. for 200.5 h at 25 deg C in sealed vials; transferred to clean vials; embryo mortalities, time to hatch and hatching failures determ.; EC50 for percent hatching success determ.

Further Details (Ecotoxi- control: embryos in rearing medium cology) Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

1.84 percent v/v

Results

increased hatching failure at >=1.5percent v/v dose; increased embryo mortality at 2.00percent v/v; no effect on time to hatch; figures

Gonzalez-Doncel, Miguel; Okihiro, Mark S.; Torija, Carlos F.; Tarazona, Jose V.; Hinton, David E.; Ecotoxicology and Environmental Safety; vol. 69; nb. 1; (2008); p. 95 - 103, View in Reaxys 2 of 142

Effect (Ecotoxicology)

embryotoxicity

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

orange-red strain medaka embryos (early blastodisc, stage 2) exposed to title comp. for 200.5 h at 25 deg C in sealed vials; transferred to clean vials; hatchlings collected daily; LOEC for percent hatching success determ.

Further Details (Ecotoxi- control: embryos in rearing medium cology) Type (Ecotoxicology)

LO(A)EC

Value of Type (Ecotoxicology)

0.50 percent v/v

Gonzalez-Doncel, Miguel; Okihiro, Mark S.; Torija, Carlos F.; Tarazona, Jose V.; Hinton, David E.; Ecotoxicology and Environmental Safety; vol. 69; nb. 1; (2008); p. 95 - 103, View in Reaxys 3 of 142

Effect (Ecotoxicology)

embryotoxicity

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

orange-red strain medaka embryos (early blastula, stage 10) exposed to title comp. for 206.5 h at 25 deg C in sealed vials; transferred to clean vials; embryo mortalities, time to hatch and hatching failures determ.; LOEC for percent hatching success determ.

Further Details (Ecotoxi- control: embryos in rearing medium cology) Type (Ecotoxicology)

LO(A)EC

2/42

2016-05-10 05:50:17

Value of Type (Ecotoxicology)

1.50 percent v/v

Results

increased hatching failure and delayed hatching at 2.00percent v/v title comp.; no effect on embryo mortalities; figures

Gonzalez-Doncel, Miguel; Okihiro, Mark S.; Torija, Carlos F.; Tarazona, Jose V.; Hinton, David E.; Ecotoxicology and Environmental Safety; vol. 69; nb. 1; (2008); p. 95 - 103, View in Reaxys 4 of 142

Effect (Ecotoxicology)

embryotoxicity

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

Further Details (Ecotoxi- control: embryos in rearing medium cology) Type (Ecotoxicology)

NO(A)EC

Value of Type (Ecotoxicology)

1.00 percent v/v

Gonzalez-Doncel, Miguel; Okihiro, Mark S.; Torija, Carlos F.; Tarazona, Jose V.; Hinton, David E.; Ecotoxicology and Environmental Safety; vol. 69; nb. 1; (2008); p. 95 - 103, View in Reaxys 5 of 142

Effect (Ecotoxicology)

embryotoxicity

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

orange-red strain medaka embryos (early blastula, stage 10) exposed to title comp. for 206.5 h at 25 deg C in sealed vials; transferred to clean vials; hatchlings collected daily; NOEC for percent hatching success determ.

Further Details (Ecotoxi- control: embryos in rearing medium cology) Type (Ecotoxicology)

NO(A)EC

Value of Type (Ecotoxicology)

2.00 percent v/v

Gonzalez-Doncel, Miguel; Okihiro, Mark S.; Torija, Carlos F.; Tarazona, Jose V.; Hinton, David E.; Ecotoxicology and Environmental Safety; vol. 69; nb. 1; (2008); p. 95 - 103, View in Reaxys 6 of 142

Effect (Ecotoxicology)

embryotoxicity

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

orange-red strain medaka embryos (early blastodisc, stage 2) exposed to title comp. for 200.5 h at 25 deg C; transferred to clean vials; developmental defects determ. at up to 72 h after emergence; larval swim bladder inflation EC50 determ.

Further Details (Ecotoxi- control: embryos in rearing medium; embryo abnormalities: hyperpigmentation, stunting cology) development, microcephalia, ocular dystrophy; larval abnormalities: weakness, spinal deformities, absence of swim bladder inflation Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

1.16 percent v/v

Results

embryo and larval abnormalities observed at >1.00percent v/v; no spinal deformities observed

3/42

2016-05-10 05:50:17

Gonzalez-Doncel, Miguel; Okihiro, Mark S.; Torija, Carlos F.; Tarazona, Jose V.; Hinton, David E.; Ecotoxicology and Environmental Safety; vol. 69; nb. 1; (2008); p. 95 - 103, View in Reaxys 7 of 142

Effect (Ecotoxicology)

embryotoxicity

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

orange-red strain medaka embryos (early blastula, stage 10) exposed to title comp. for 206.5 h, 25 deg C in sealed vials; transferred to clean vials; developmental defects determ. at up to 72 h after emergence; larval swim bladder inflation EC50 determ.

EC50

Value of Type (Ecotoxicology)

1.30 percent v/v

Results

embryo and larval abnormalities observed at >1.00percent v/v; no spinal deformities observed

Gonzalez-Doncel, Miguel; Okihiro, Mark S.; Torija, Carlos F.; Tarazona, Jose V.; Hinton, David E.; Ecotoxicology and Environmental Safety; vol. 69; nb. 1; (2008); p. 95 - 103, View in Reaxys 8 of 142

Effect (Ecotoxicology)

embryotoxicity

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

orange-red strain medaka embryos (early blastodisc, stage 2) exposed to title comp. for 200.5 h at 25 deg C in sealed vials; transferred to clean vials; absence of larval swim bladder inflation determ. for up to 72 h after emergence

Further Details (Ecotoxi- control: embryos in rearing medium cology) Type (Ecotoxicology)

LO(A)EC

Value of Type (Ecotoxicology)

1.00 percent v/v

Gonzalez-Doncel, Miguel; Okihiro, Mark S.; Torija, Carlos F.; Tarazona, Jose V.; Hinton, David E.; Ecotoxicology and Environmental Safety; vol. 69; nb. 1; (2008); p. 95 - 103, View in Reaxys 9 of 142

Effect (Ecotoxicology)

embryotoxicity

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

orange-red strain medaka embryos (early blastula, stage 10) exposed to title comp. for 206.5 h at 25 deg C in sealed vials; transferred to clean vials; absence of larval swim bladder inflation determ. for up to 72 h after emergence

Further Details (Ecotoxi- control: embryos in rearing medium cology) Type (Ecotoxicology)

LO(A)EC

Value of Type (Ecotoxicology)

1.00 percent v/v

Gonzalez-Doncel, Miguel; Okihiro, Mark S.; Torija, Carlos F.; Tarazona, Jose V.; Hinton, David E.; Ecotoxicology and Environmental Safety; vol. 69; nb. 1; (2008); p. 95 - 103, View in Reaxys 10 of 142

Effect (Ecotoxicology)

embryotoxicity

4/42

2016-05-10 05:50:17

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

Further Details (Ecotoxi- control: embryos in rearing medium cology) Type (Ecotoxicology)

NO(A)EC

Value of Type (Ecotoxicology)

1.50 percent v/v

Effect (Ecotoxicology)

embryotoxicity

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

Further Details (Ecotoxi- control: embryos in rearing medium cology) Type (Ecotoxicology)

NO(A)EC

Value of Type (Ecotoxicology)

1.50 percent v/v

Effect (Ecotoxicology)

embryotoxicity

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

Further Details (Ecotoxi- control: embryos in rearing medium; MATC: maximum allowable toxic concentration cology) Type (Ecotoxicology)

MATC

Value of Type (Ecotoxicology)

1.22 percent v/v

Effect (Ecotoxicology)

embryotoxicity

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

orange-red strain medaka embryos (early blastodisc, stage 10) exposed to title comp. for 206.5 h at 25 deg C in sealed vials; transferred to clean vials; absence of larval swim bladder inflation determ. for up to 72 h after emergence

5/42

2016-05-10 05:50:17

Further Details (Ecotoxi- control: embryos in rearing medium; MATC: maximum allowable toxic concentration cology) Type (Ecotoxicology)

MATC

Value of Type (Ecotoxicology)

1.22 percent v/v

Effect (Ecotoxicology)

embryotoxicity

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

Further Details (Ecotoxi- control: embryos in rearing medium; MATC: maximum allowable toxicant concentration cology) Type (Ecotoxicology)

MATC

Value of Type (Ecotoxicology)

0.71 percent v/v

Effect (Ecotoxicology)

embryotoxicity

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

Further Details (Ecotoxi- control: embryos in rearing medium; MATC: maximum allowable toxicant concentration cology) Type (Ecotoxicology)

MATC

Value of Type (Ecotoxicology)

1.73 percent v/v

Effect (Ecotoxicology)

embryotoxicity

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

Further Details (Ecotoxi- control: embryos in rearing medium cology) Type (Ecotoxicology)

LO(A)EC

Value of Type (Ecotoxicology)

1.50 percent v/v

Gonzalez-Doncel, Miguel; Okihiro, Mark S.; Torija, Carlos F.; Tarazona, Jose V.; Hinton, David E.; Ecotoxicology and Environmental Safety; vol. 69; nb. 1; (2008); p. 95 - 103, View in Reaxys

6/42

2016-05-10 05:50:17

17 of 142

Effect (Ecotoxicology)

embryotoxicity

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

Further Details (Ecotoxi- control: embryos in rearing medium cology) Type (Ecotoxicology)

NO(A)EC

Value of Type (Ecotoxicology)

2.00 percent v/v

Effect (Ecotoxicology)

embryotoxicity

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

Further Details (Ecotoxi- control: embryos in rearing medium; MATC: maximum allowable toxicant concentration cology) Type (Ecotoxicology)

MATC

Value of Type (Ecotoxicology)

1.73 percent v/v

Effect (Ecotoxicology)

embryotoxicity

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

Further Details (Ecotoxi- control: embryos in rearing medium; MATC: maximum allowable toxicant concentration cology) Type (Ecotoxicology)

MATC

Value of Type (Ecotoxicology)

1.73 percent v/v

Effect (Ecotoxicology)

embryotoxicity

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium

7/42

2016-05-10 05:50:17

Method (Ecotoxicology)

Further Details (Ecotoxi- control: embryos in rearing medium cology) Type (Ecotoxicology)

LO(A)EC

Value of Type (Ecotoxicology)

1.50 percent v/v

Effect (Ecotoxicology)

embryotoxicity

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

Further Details (Ecotoxi- control: embryos in rearing medium cology) Type (Ecotoxicology)

NO(A)EC

Value of Type (Ecotoxicology)

2.00 percent v/v

Effect (Ecotoxicology)

hatching delay; induction of

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

orange-red strain medaka embryos (early blastodisc, stage 10) exposed to title comp. for 206.5 h at 25 deg C in sealed vials; transferred to clean vials; time to hatch observed

Further Details (Ecotoxi- control: embryos in rearing medium; MATC: maximum allowable toxic concentration cology) Results

title comp. induced delayed hatch at 2.00percent v/v; fig.

Effect (Ecotoxicology)

mortality rate; effect on

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

orange-red strain medaka embryos (stages 2 and 10) exposed to title comp. for 200.5-206.5 h at 25 deg C in sealed vials; transferred to clean vials; embryo mortalities observed

Further Details (Ecotoxi- control: embryos in rearing medium; mortality characterized by absence of heartbeat and cology) blood stagnation Results

incidence of embryo mortality observed in the stage-2 group and at the highest title comp. conc.; fig.

Effect (Ecotoxicology)

spinal development; induction of

8/42

2016-05-10 05:50:17

Species or Test-System (Ecotoxicology)

embryo of Oryzias latipes, Japanese medaka

Kind of Dosing (Ecotoxi- title comp. solution (0.06, 0.13, 0.25, 0.50, 1.00, 1.50 and 2.00percent v/v) prepared in cology) rearing medium Method (Ecotoxicology)

orange-red strain medaka embryos (stage 2 and 10) exposed to title comp. for 200.5-206.5 h at 25 deg C in sealed vials; transferred to clean vials; spinal development 72 h after emergence observed for deformities

Further Details (Ecotoxi- control: embryos in rearing medium cology) Results

stage-specific response observed; earlier exposure time (stage-2 group) found more sensitive than later exposure time (stage-10) group at >=0.05percent v/v title comp.; fig.

Effect (Ecotoxicology)

enzyme activity; inhibition of

Species or Test-System (Ecotoxicology)

laccase of Marasmius quercophilus 19, white-rot fungus

Kind of Dosing (Ecotoxi- title comp. admin. at final conc. of 5, 10, 15, 20, 30, 50, 70 and 80percent v/v in the reaccology) tion mixture Method (Ecotoxicology)

purified enzyme in acetate buffer, pH 4, with ABTS as substrate and title comp.; reacted for 2 min; enzyme activity determ.

Further Details (Ecotoxi- control: reaction mixture without title comp.; IC50: inhibiting conc. where 50percent laccology) case activity remains Type (Ecotoxicology)

IC50

Value of Type (Ecotoxicology)

40 percent v/v

Results

decreased in enzyme activity started at 25percent v/v title comp. conc.; figure

Farnet; Gil; Ferre; Chemosphere; vol. 70; nb. 5; (2008); p. 895 - 900, View in Reaxys 26 of 142

Effect (Ecotoxicology)

enzyme activity; effect on

Species or Test-System (Ecotoxicology)

laccase of Marasmius quercophilus 19, white-rot fungus

Kind of Dosing (Ecotoxi- title comp. admin. at final conc. of 5, 10, 15, 20, 30, 50, 70 and 80percent v/v in the reaccology) tion mixture Method (Ecotoxicology)

purified enzyme in acetate buffer, pH 4, with syringaldazine as substrate and title comp.; reacted for 2 min; enzyme activity determ.

Further Details (Ecotoxi- control: reaction mixture without title comp.; IC50: inhibiting conc. where 50percent laccology) case activity remains Type (Ecotoxicology)

IC50

Value of Type (Ecotoxicology)

60 percent v/v

Results

increased in enzyme activity observed up to 40percent v/v title comp. and decreased >=50percent v/v conc.; figure

Farnet; Gil; Ferre; Chemosphere; vol. 70; nb. 5; (2008); p. 895 - 900, View in Reaxys 27 of 142

Effect (Ecotoxicology)

photosynthetic activity; inhibition of

Species or Test-System (Ecotoxicology)

Selenastrum capricornutum ATCC-22662, freshwater green alga

Kind of Dosing (Ecotoxi- title comp. dissolved in deionized water cology) Method (Ecotoxicology)

acute toxicity test; microalgal suspension along with title comp. injected into reaction vessel; homogenized; light beam supplied with 150-W quartz halogen lamp at 1000 μE m-2 s-1; log10EC50 for photosynthetic activity determined

9/42

2016-05-10 05:50:17

Further Details (Ecotoxi- control: deionized water cology) Results

log10EC50: ca. 6.3 μM; figure

Pham, Thi Phuong Thuy; Cho, Chul-Woong; Vijayaraghavan, Kuppusamy; Min, Jiho; Yun, Yeoung-Sang; Environmental Toxicology and Chemistry; vol. 27; nb. 7; (2008); p. 1583 - 1589, View in Reaxys 28 of 142

Effect (Ecotoxicology)

growth; inhibition of

Species or Test-System (Ecotoxicology)

Selenastrum capricornutum ATCC-22662, freshwater green alga

Kind of Dosing (Ecotoxi- title comp. dissolved in deionized water cology) Method (Ecotoxicology)

chronic toxicity test according to USEPA and OECD guidelines; 7-d algal cells inoculated into flask containing title comp.; incub. for 96 h; OD of biomass measured by spectrophotometer at 438 nm; log10EC50 for average specific growth rate determined

Further Details (Ecotoxi- control: deionized water; OD: optical density cology) Results

log10EC50: ca. 5.88 μM; figure

Effect (Ecotoxicology)

phospholipid biosynthesis; inhibition of

Species or Test-System (Ecotoxicology)

Gossypium hirsutum L., cotton

Concentration (Ecotoxicology)

10000 ppm

Method (Ecotoxicology)

under laboratory conditions; seeds of cotton variety 108-F germinated in water containing title comp.; phospholipid composition of 1 to 8-day sprouts determined by two-dimensional micro-TLC

Further Details (Ecotoxi- control: no title comp. cology) Results

title comp. showed time-dependent decrease in content of phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidic acid and total phospholipids as compared to respective control; tab.; fig.

Abdullaeva; Chemistry of Natural Compounds; vol. 44; nb. 2; (2008); p. 155 - 157, View in Reaxys 30 of 142

Effect (Ecotoxicology)

biotransformation

Species or Test-System (Ecotoxicology)

Gossypium hirsutum L., cotton

Concentration (Ecotoxicology)

10000 ppm

Method (Ecotoxicology)

under laboratory conditions; seeds of cotton variety 108-F germinated in water containing title comp.; phospholipid composition of 1 to 5-day sprouts determined by two-dimensional micro-TLC

Further Details (Ecotoxi- control: no title comp. cology) Results

formation of phosphatidylmethanol detected; its content reached maximum on day 3 of growth; tab.

Abdullaeva; Chemistry of Natural Compounds; vol. 44; nb. 2; (2008); p. 155 - 157, View in Reaxys 31 of 142

Effect (Ecotoxicology)

growth; inhibition of

Species or Test-System (Ecotoxicology)

Gossypium hirsutum L., cotton

Concentration (Ecotoxicology)

10000 ppm

Method (Ecotoxicology)

under laboratory conditions; seeds of cotton variety 108-F germinated in water containing title comp.

10/42

2016-05-10 05:50:17

Further Details (Ecotoxi- control: no title comp. cology) Results

title comp. caused decrease in length of 5-day rootlets, decrease in biomass accumulation and complete inhibition of development in subsequent days

Abdullaeva; Chemistry of Natural Compounds; vol. 44; nb. 2; (2008); p. 155 - 157, View in Reaxys 32 of 142

Effect (Ecotoxicology)

enzyme activity; inhibition of

Species or Test-System (Ecotoxicology)

Gossypium hirsutum L., cotton

Concentration (Ecotoxicology)

10000 ppm

Method (Ecotoxicology)

under laboratory conditions; seeds of cotton variety 108-F germinated in water containing title comp.; phytase activity of cotton seeds and 1 to 9-day sprouts determined

Further Details (Ecotoxi- control: no title comp. cology) Results

title comp. prevented activation of phytase and almost completely inhibited its activity; fig.

Abdullaeva; Chemistry of Natural Compounds; vol. 44; nb. 2; (2008); p. 155 - 157, View in Reaxys 33 of 142

Effect (Ecotoxicology)

enzyme activity; effect on

Species or Test-System (Ecotoxicology)

Gossypium hirsutum L., cotton

Concentration (Ecotoxicology)

10000 ppm

Method (Ecotoxicology)

under laboratory conditions; seeds of cotton variety 108-F germinated in water containing title comp.; hydrolytic activity of phospholipase D up to day 9 determined from amount of choline released by hydrolysis of phospholipids

Further Details (Ecotoxi- control: no title comp. cology) Comment (Ecotoxicology)

No effect

Abdullaeva; Chemistry of Natural Compounds; vol. 44; nb. 2; (2008); p. 155 - 157, View in Reaxys 34 of 142

Effect (Ecotoxicology)

enzyme activity; inhibition of

Species or Test-System (Ecotoxicology)

Gossypium hirsutum L., cotton

Concentration (Ecotoxicology)

10000 ppm

Method (Ecotoxicology)

under laboratory conditions; seeds of cotton variety 108-F germinated in water containing title comp.; transferase activity of phospholipase D determined from rate of transalkylation of phosphatidylcholine in presence of alcohol substrates

Further Details (Ecotoxi- control: no title comp. cology) Results

title comp. inhibited transferase activity of phospholipase D

Abdullaeva; Chemistry of Natural Compounds; vol. 44; nb. 2; (2008); p. 155 - 157, View in Reaxys 35 of 142

Effect (Ecotoxicology)

growth; inhibition of

Species or Test-System (Ecotoxicology)

Selenastrum capricornutum ATCC-22662, green microalga

Concentration (Ecotoxicology)

1.26 - 100000 μmol/l

Kind of Dosing (Ecotoxi- title comp. dissolved in water cology) Method (Ecotoxicology)

toxicity test acc. to EPA (EPA, 1996) and OECD guidelines (OECD, 2002); 7-d algae exposed to title comp.; incub. for 48, 72, 96 h at 25 deg C; biomass OD measured by spectrophotometer at 438 nm; average specific growth rate determ.; log10EC50 calcul.

11/42

2016-05-10 05:50:17

Further Details (Ecotoxi- control: without title comp. cology) Results

log10EC50/exposure time (h): 5.85/96; table

Cho, Chul-Woong; Jeon, You-Chul; Pham, Thi Phuong Thuy; Vijayaraghavan; Yun, Yeoung-Sang; Ecotoxicology and Environmental Safety; vol. 71; nb. 1; (2008); p. 166 - 171, View in Reaxys 36 of 142

Effect (Ecotoxicology)

enzyme activity; effect on

Species or Test-System (Ecotoxicology)

acetylcholinesterase from eel electrophorus electricus

Concentration (Ecotoxicology)

0.14 - 0.8 μmol/l

Method (Ecotoxicology)

enzyme were incubated with title comp. for 1h at 37 deg C; effect of ASP on AChE was measured spectrophotometrically by increase in absorbance at 412 nm

Further Details (Ecotoxi- AChE: acetylcholinesterase; control: without title comp. cology) Results

title comp. had not statistically significant effect on eel electrophorus electricus AChE at 0.14 mM and statistically significant at 0.60 to 0.80 mM

Simintzi, Irene; Schulpis, Kleopatra H.; Angelogianni, Panagoula; Liapi, Charis; Tsakiris, Stylianos; Food and Chemical Toxicology; vol. 45; nb. 12; (2007); p. 2397 - 2401, View in Reaxys 37 of 142

Effect (Ecotoxicology)

growth; inhibition of

Species or Test-System (Ecotoxicology)

Chlorella pyrenoidosa, green alga

Method (Ecotoxicology)

HB-4 medium contained cells treated with title comp.; incubation time: 96 h; 25 deg C; shaken (100 rpm); under continuous light intensity of 5000 lx; culture growth monitored spectrophotometrically at 680 nm

Further Details (Ecotoxi- EC50: title comp. concentration required to cause 50percent reduction in growth cology) Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

0.80 mg/l

Results

percent inhibition increased with log of title comp. conc.; equation

Ma, Jianyi; Chen, Jianmeng; Environmental Pollution; vol. 136; nb. 2; (2005); p. 267 - 273, View in Reaxys 38 of 142

Effect (Ecotoxicology)

biotransformation

Species or Test-System (Ecotoxicology)

Populus deltoides x nigra DN-34

Concentration (Ecotoxicology)

5 mg/l

Exposure Period (Ecotoxicology)

16 d

Method (Ecotoxicology)

tissue cultures from young leaves and stems cultivated in Murashige and Skoog medium; with 14C-labelled title comp.; in dark and exposed to light (16 h/8 h light/dark photoperiod); 60 rpm; HPLC analysis and liquid scintillation counting

Further Details (Ecotoxi- light intensity: 150 μmol/(s m2) cology) Results

12 percent and 13 percent of title comp. mineralised in dark and exposed to light, respectively; mineralisation rate in dark and exposed to light (μg/(g of biomass day)): 2.0 and 2.1, respectively; radioactivity mass balance presented; table

Metabolite (Ecotoxicology)

carbon dioxide

Van Aken, Benoit; Yoon, Jong M.; Just, Craig L.; Schnoor, Jerald L.; Environmental Science and Technology; vol. 38; nb. 17; (2004); p. 4572 - 4579, View in Reaxys 39 of 142

Effect (Ecotoxicology)

biotransformation

12/42

2016-05-10 05:50:17

Species or Test-System (Ecotoxicology)

Streptomyces coelicolor A3(2) α-keto ester reductase

Method (Ecotoxicology)

test enzyme incubated with title comp. in presence of NAD(+) as coenzyme; products analysed with chromatography

Comment (Ecotoxicology)

No effect

Ishihara, Kohji; Yamaguchi, Hitomi; Omori, Taketo; Uemura, Tadashi; Nakajima, Nobuyoshi; Esaki, Nobuyoshi; Bioscience, Biotechnology and Biochemistry; vol. 68; nb. 10; (2004); p. 2120 - 2127, View in Reaxys 40 of 142

Effect (Ecotoxicology)

growth; inhibition of

Species or Test-System (Ecotoxicology)

Scenedesmus vacuolatus (Shih. et Krauss) 211-15, green alga

Kind of Dosing (Ecotoxi- title comp. dissolved in DMSO cology) Method (Ecotoxicology)

7.5E4 cells/ml incub. with title comp. for 24 h at pH 6.9 under FL (13-18 W/m and 350 μeinstein s-1 m-2 PAR); mean cell number analyzed and ICR determined taking ICR after one generation as effect parameter; title comp. conc. analyzed with HPLC

Further Details (Ecotoxi- FL: fluorescent light; PAR: photosynthetic active radiation; ICR: inhibition of cell reproduccology) tion expressed as percent of cell number increase in control cultures; controls: untreated culture and solvent control Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

0.77 μmol/l

Altenburger, Rolf; Walter, Helge; Grote, Matthias; Environmental Science and Technology; vol. 38; nb. 23; (2004); p. 6353 - 6362, View in Reaxys 41 of 142

Effect (Ecotoxicology)

antifungal

Species or Test-System (Ecotoxicology)

Colletotrichum gloeosporioides

Kind of Dosing (Ecotoxi- as solution in acetone cology) Method (Ecotoxicology)

effect on mycelial growth on potato-dextrose-agar medium assessed using poisoned food technique

Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

24687 mg/l

Results

pEC50 (mol/l): 0.11

Nidiry, Eugene Sebastian J.; Journal of Agricultural and Food Chemistry; vol. 51; nb. 18; (2003); p. 5337 - 5343, View in Reaxys 42 of 142

Effect (Ecotoxicology)

antifungal

Species or Test-System (Ecotoxicology)

Colletotrichum gloeosporioides

Kind of Dosing (Ecotoxi- as solution in acetone cology) Method (Ecotoxicology)

effect on mycelial growth on potato-dextrose-agar medium assessed using poisoned food technique

Type (Ecotoxicology)

LO(A)EC

Value of Type (Ecotoxicology)

7999 mg/l

Results

pLOEC (mol/l): 0.60

Nidiry, Eugene Sebastian J.; Journal of Agricultural and Food Chemistry; vol. 51; nb. 18; (2003); p. 5337 - 5343, View in Reaxys 43 of 142

Effect (Ecotoxicology)

growth stimulant

13/42

2016-05-10 05:50:17

Species or Test-System (Ecotoxicology)

Lemna gibba

Concentration (Ecotoxicology)

0.1 - 1 percent v/v

Exposure Period (Ecotoxicology)

24 - 48 h

Method (Ecotoxicology)

triple-fronded L. gibba plants in the exponential growth phase were placed in petri dishes with growth medium containing title comp.; fluorescence measurements

Further Details (Ecotoxi- growth rate expressed in percentage of biomass compared control (untreated plant) - 100 cology) percent Results

title comp. induced stimulatory effect on growth of biomass at concentrations 0.1-0.2 percent during 24 h exposure; when the treatment was longer than 24 h, the stimulatory effect was less evident

Dewez, David; Dautremepuits, Claire; Jeandet, Philippe; Vernet, Guy; Popovic, Radovan; Photochemistry and Photobiology; vol. 78; nb. 4; (2003); p. 420 - 424, View in Reaxys 44 of 142

Effect (Ecotoxicology)

growth; inhibition of

Species or Test-System (Ecotoxicology)

Lemna gibba

Concentration (Ecotoxicology)

0.1 - 1 percent v/v

Exposure Period (Ecotoxicology)

24 - 48 h

Method (Ecotoxicology)

triple-fronded L. gibba plants in the exponential growth phase were placed in petri dishes with growth medium containing title comp.; fluorescence measurements

Further Details (Ecotoxi- growth rate expressed in percentage of biomass compared control (untreated plant) - 100 cology) percent Results

when the concentration of title comp. was 0.5 percent or higher, inhibitory effect on photosynthesis and growth was evident especially when plant cells were exposed for a long period (48 h)

Dewez, David; Dautremepuits, Claire; Jeandet, Philippe; Vernet, Guy; Popovic, Radovan; Photochemistry and Photobiology; vol. 78; nb. 4; (2003); p. 420 - 424, View in Reaxys 45 of 142

Effect (Ecotoxicology)

toxicity to bacteria

Species or Test-System (Ecotoxicology)

Shk1 cells

Kind of Dosing (Ecotoxi- assay solutions made by making serial dilutions of stock solutions; test solutions admin. at cology) a 1:3 volume ratio (Shk1 cell sol. : test solution) Method (Ecotoxicology)

continuous-stirred tank reactor; dilution rate of 0.52 h-1; pH 7; 22 deg C; bioluminescence measured after exposure for 5 min

Further Details (Ecotoxi- Shk1 is genetically modified luminescent bacterium whose original strain Pseudomonad, cology) isolated from the activated sludge; control = buffer (pH: 7) Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

39899 mg/l

Frymier; Ren; Water Research; vol. 36; nb. 17; (2002); p. 4406 - 4414, View in Reaxys 46 of 142

Effect (Ecotoxicology)

enzyme; inhibition of

Endpoint of Effect (Ecotoxicology)

β-galactosidase activity

Species or Test-System (Ecotoxicology)

β-galactosidase from eukaryote yeast Kluyveromyces lactis

Kind of Dosing (Ecotoxi- assay performed with seven concentrations of title comp. cology)

14/42

2016-05-10 05:50:17

Method (Ecotoxicology)

enzyme with title comp. incubated in phosphate buffer (pH 6.6) at 37 deg C for 5, 15, 30, or 60 min; then o-nitrophenyl-β-D-galactopyranoside substrate added for colour development; mixture incubated at 37 deg C for 5 min; absorbance measured at 405 nm

Further Details (Ecotoxi- negative control cology) Type (Ecotoxicology)

IC50

Value of Type (Ecotoxicology)

2818 - 5164 mg/l

Results

time-dependent inhibition

Apartin, Carina; Ronco, Alicia; Environmental Toxicology; vol. 16; nb. 2; (2001); p. 117 - 120, View in Reaxys 47 of 142

Effect (Ecotoxicology)

phytotoxicity

Endpoint of Effect (Ecotoxicology)

discoloration and wilting of leaves

Species or Test-System (Ecotoxicology)

Pinus thunbergii, Japanese black pine

Concentration (Ecotoxicology)

1 ml

Method (Ecotoxicology)

pot-grown 4-year-old trees, 40 cm in hight, 1.6 cm in basal diameter, kept in greenhouse for 4 months prior to study; injection into the hole (3*10 mm); observation for 1 month

Results

no enjurious effect excerpt discoloration of the cambiun around the injection hole

Takai, Kazuya; Soejima, Tomoyuki; Suzuki, Toshio; Kawazu, Kazuyoshi; Pest Management Science; vol. 57; nb. 5; (2001); p. 463 - 466, View in Reaxys 48 of 142

Effect (Ecotoxicology)

phytotoxicity

Species or Test-System (Ecotoxicology)

Tetraselmis tetrathele

Concentration (Ecotoxicology)

17 - 53000 ppm

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

algae were cultured at temp. 20 deg C, under illumination of 3500-4500 lux and 14:10 light:dark cycle; growth of algae monitored daily by in vivo fluorescence

Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

Ca. 28000 ppm

Okumura; Koyama; Takaku; Satoh; Archives of Environmental Contamination and Toxicology; vol. 41; nb. 2; (2001); p. 123 - 128, View in Reaxys 49 of 142

Effect (Ecotoxicology)

phytotoxicity

Species or Test-System (Ecotoxicology)

Dunaliella tertiolecta

Concentration (Ecotoxicology)

17 - 53000 ppm

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

algae were cultured at temp. 20 deg C, under illumination of 3500-4500 lux and 14:10 light:dark cycle; growth of algae monitored daily by in vivo fluorescence

Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

Ca. 24000 ppm

Okumura; Koyama; Takaku; Satoh; Archives of Environmental Contamination and Toxicology; vol. 41; nb. 2; (2001); p. 123 - 128, View in Reaxys 50 of 142

Effect (Ecotoxicology)

phytotoxicity

15/42

2016-05-10 05:50:17

Species or Test-System (Ecotoxicology)

Isochrysis galbana

Concentration (Ecotoxicology)

17 - 53000 ppm

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

algae were cultured at temp. 20 deg C, under illumination of 3500-4500 lux and 14:10 light:dark cycle; growth of algae monitored daily by in vivo fluorescence

Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

Ca. 22000 ppm

Okumura; Koyama; Takaku; Satoh; Archives of Environmental Contamination and Toxicology; vol. 41; nb. 2; (2001); p. 123 - 128, View in Reaxys 51 of 142

Effect (Ecotoxicology)

phytotoxicity

Species or Test-System (Ecotoxicology)

Pavlova lutheri

Concentration (Ecotoxicology)

17 - 53000 ppm

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

algae were cultured at temp. 20 deg C, under illumination of 3500-4500 lux and 14:10 light:dark cycle; growth of algae monitored daily by in vivo fluorescence

Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

Ca. 20000 ppm

Okumura; Koyama; Takaku; Satoh; Archives of Environmental Contamination and Toxicology; vol. 41; nb. 2; (2001); p. 123 - 128, View in Reaxys 52 of 142

Effect (Ecotoxicology)

phytotoxicity

Species or Test-System (Ecotoxicology)

Chaetoceros calcitrans

Concentration (Ecotoxicology)

17 - 53000 ppm

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

algae were cultured at temp. 20 deg C, under illumination of 3500-4500 lux and 14:10 light:dark cycle; growth of algae monitored daily by in vivo fluorescence

Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

Ca. 17000 ppm

Okumura; Koyama; Takaku; Satoh; Archives of Environmental Contamination and Toxicology; vol. 41; nb. 2; (2001); p. 123 - 128, View in Reaxys 53 of 142

Effect (Ecotoxicology)

phytotoxicity

Species or Test-System (Ecotoxicology)

Skeletonema costatum

Concentration (Ecotoxicology)

17 - 53000 ppm

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

algae were cultured at temp. 20 deg C, under illumination of 3500-4500 lux and 14:10 light:dark cycle; growth of algae monitored daily by in vivo fluorescence

Type (Ecotoxicology)

EC50

16/42

2016-05-10 05:50:17

Value of Type (Ecotoxicology)

Ca. 8000 ppm

Okumura; Koyama; Takaku; Satoh; Archives of Environmental Contamination and Toxicology; vol. 41; nb. 2; (2001); p. 123 - 128, View in Reaxys 54 of 142

Effect (Ecotoxicology)

phytotoxicity

Species or Test-System (Ecotoxicology)

Prorocentrum minimum

Concentration (Ecotoxicology)

17 - 53000 ppm

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

algae were cultured at temp. 20 deg C, under illumination of 3500-4500 lux and 14:10 light:dark cycle; growth of algae monitored daily by in vivo fluorescence

Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

Ca. 4000 ppm

Okumura; Koyama; Takaku; Satoh; Archives of Environmental Contamination and Toxicology; vol. 41; nb. 2; (2001); p. 123 - 128, View in Reaxys 55 of 142

Effect (Ecotoxicology)

phytotoxicity

Species or Test-System (Ecotoxicology)

Eutreptiella sp.

Concentration (Ecotoxicology)

17 - 53000 ppm

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

algae were cultured at temp. 20 deg C, under illumination of 3500-4500 lux and 14:10 light:dark cycle; growth of algae monitored daily by in vivo fluorescence

Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

Ca. 140 ppm

Okumura; Koyama; Takaku; Satoh; Archives of Environmental Contamination and Toxicology; vol. 41; nb. 2; (2001); p. 123 - 128, View in Reaxys 56 of 142

Effect (Ecotoxicology)

phytotoxicity

Species or Test-System (Ecotoxicology)

Heterosigma akashiwo

Concentration (Ecotoxicology)

17 - 53000 ppm

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

algae were cultured at temp. 20 deg C, under illumination of 3500-4500 lux and 14:10 light:dark cycle; growth of algae monitored daily by in vivo fluorescence

Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

Ca. 500 ppm

Okumura; Koyama; Takaku; Satoh; Archives of Environmental Contamination and Toxicology; vol. 41; nb. 2; (2001); p. 123 - 128, View in Reaxys 57 of 142

Effect (Ecotoxicology)

phytotoxicity

Species or Test-System (Ecotoxicology)

Tetraselmis tetrathele

Concentration (Ecotoxicology)

17 - 53000 ppm

17/42

2016-05-10 05:50:17

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

algae were cultured at temp. 20 deg C, under illumination of 3500-4500 lux and 14:10 light:dark cycle; growth of algae monitored daily by in vivo fluorescence

Type (Ecotoxicology)

NO(A)EC

Value of Type (Ecotoxicology)

Ca. 14000 ppm

Okumura; Koyama; Takaku; Satoh; Archives of Environmental Contamination and Toxicology; vol. 41; nb. 2; (2001); p. 123 - 128, View in Reaxys 58 of 142

Effect (Ecotoxicology)

phytotoxicity

Species or Test-System (Ecotoxicology)

Dunaliella tertiolecta

Concentration (Ecotoxicology)

17 - 53000 ppm

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

algae were cultured at temp. 20 deg C, under illumination of 3500-4500 lux and 14:10 light:dark cycle; growth of algae monitored daily by in vivo fluorescence

Type (Ecotoxicology)

NO(A)EC

Value of Type (Ecotoxicology)

Ca. 10000 ppm

Okumura; Koyama; Takaku; Satoh; Archives of Environmental Contamination and Toxicology; vol. 41; nb. 2; (2001); p. 123 - 128, View in Reaxys 59 of 142

Effect (Ecotoxicology)

phytotoxicity

Species or Test-System (Ecotoxicology)

Isochrysis galbana

Concentration (Ecotoxicology)

17 - 53000 ppm

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

algae were cultured at temp. 20 deg C, under illumination of 3500-4500 lux and 14:10 light:dark cycle; growth of algae monitored daily by in vivo fluorescence

Type (Ecotoxicology)

NO(A)EC

Value of Type (Ecotoxicology)

Ca. 8100 ppm

Okumura; Koyama; Takaku; Satoh; Archives of Environmental Contamination and Toxicology; vol. 41; nb. 2; (2001); p. 123 - 128, View in Reaxys 60 of 142

Effect (Ecotoxicology)

phytotoxicity

Species or Test-System (Ecotoxicology)

Pavlova lutheri

Concentration (Ecotoxicology)

17 - 53000 ppm

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

algae were cultured at temp. 20 deg C, under illumination of 3500-4500 lux and 14:10 light:dark cycle; growth of algae monitored daily by in vivo fluorescence

Type (Ecotoxicology)

NO(A)EC

Value of Type (Ecotoxicology)

Ca. 5700 ppm

Okumura; Koyama; Takaku; Satoh; Archives of Environmental Contamination and Toxicology; vol. 41; nb. 2; (2001); p. 123 - 128, View in Reaxys

18/42

2016-05-10 05:50:17

61 of 142

Effect (Ecotoxicology)

phytotoxicity

Species or Test-System (Ecotoxicology)

Chaetoceros calcitrans

Concentration (Ecotoxicology)

17 - 53000 ppm

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

algae were cultured at temp. 20 deg C, under illumination of 3500-4500 lux and 14:10 light:dark cycle; growth of algae monitored daily by in vivo fluorescence

Type (Ecotoxicology)

NO(A)EC

Value of Type (Ecotoxicology)

Ca. 5600 ppm

Okumura; Koyama; Takaku; Satoh; Archives of Environmental Contamination and Toxicology; vol. 41; nb. 2; (2001); p. 123 - 128, View in Reaxys 62 of 142

Effect (Ecotoxicology)

phytotoxicity

Species or Test-System (Ecotoxicology)

Skeletonema costatum

Concentration (Ecotoxicology)

17 - 53000 ppm

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

algae were cultured at temp. 20 deg C, under illumination of 3500-4500 lux and 14:10 light:dark cycle; growth of algae monitored daily by in vivo fluorescence

Type (Ecotoxicology)

NO(A)EC

Value of Type (Ecotoxicology)

Ca. 1400 ppm

Okumura; Koyama; Takaku; Satoh; Archives of Environmental Contamination and Toxicology; vol. 41; nb. 2; (2001); p. 123 - 128, View in Reaxys 63 of 142

Effect (Ecotoxicology)

phytotoxicity

Species or Test-System (Ecotoxicology)

Prorocentrum minimum

Concentration (Ecotoxicology)

17 - 53000 ppm

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

algae were cultured at temp. 20 deg C, under illumination of 3500-4500 lux and 14:10 light:dark cycle; growth of algae monitored daily by in vivo fluorescence

Type (Ecotoxicology)

NO(A)EC

Value of Type (Ecotoxicology)

Ca. 410 ppm

Okumura; Koyama; Takaku; Satoh; Archives of Environmental Contamination and Toxicology; vol. 41; nb. 2; (2001); p. 123 - 128, View in Reaxys 64 of 142

Effect (Ecotoxicology)

phytotoxicity

Species or Test-System (Ecotoxicology)

Eutreptiella sp.

Concentration (Ecotoxicology)

17 - 53000 ppm

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

algae were cultured at temp. 20 deg C, under illumination of 3500-4500 lux and 14:10 light:dark cycle; growth of algae monitored daily by in vivo fluorescence

19/42

2016-05-10 05:50:17

Type (Ecotoxicology)

NO(A)EC

Value of Type (Ecotoxicology)

Ca. 24 ppm

Okumura; Koyama; Takaku; Satoh; Archives of Environmental Contamination and Toxicology; vol. 41; nb. 2; (2001); p. 123 - 128, View in Reaxys 65 of 142

Effect (Ecotoxicology)

phytotoxicity

Species or Test-System (Ecotoxicology)

Heterosigma akashiwo

Concentration (Ecotoxicology)

17 - 53000 ppm

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

algae were cultured at temp. 20 deg C, under illumination of 3500-4500 lux and 14:10 light:dark cycle; growth of algae monitored daily by in vivo fluorescence

Type (Ecotoxicology)

NO(A)EC

Value of Type (Ecotoxicology)

Ca. 71 ppm

Okumura; Koyama; Takaku; Satoh; Archives of Environmental Contamination and Toxicology; vol. 41; nb. 2; (2001); p. 123 - 128, View in Reaxys 66 of 142

Effect (Ecotoxicology)

toxicity to bacteria

Species or Test-System (Ecotoxicology)

Vibrio fischere, bioluminescent bacterium

Exposure Period (Ecotoxicology)

5 min

Method (Ecotoxicology)

15 deg C; pH 7.0; 3 assay; in series 8 conc. using double dilution; also EC20 and EC80 determ.; inhibishion determined with ToxAlert 10, Microtox and LUMIStox

Further Details (Ecotoxi- zinc sulphate as standart cology) Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

44400 - 88500 ppm

Results

comparisons of EC20, EC50 and EC80 in ToxAlert 10, Microtox and LUMIStox (figure)

Jennings, Victor L. K.; Rayner-Brandes, Michael H.; Bird, David J.; Water Research; vol. 35; nb. 14; (2001); p. 3448 - 3456, View in Reaxys 67 of 142

Effect (Ecotoxicology)

toxicity to bacteria

Species or Test-System (Ecotoxicology)

Vibrio fischeri, marine bacterium

Kind of Dosing (Ecotoxi- title comp. osmotically adjusted; serial dilution with initial conc. of 45 percent (v/v) precology) pared using Microtox diluent Method (Ecotoxicology)

in vitro; Microtox assay; lyophilized bacterial reagent reconstituted; stabilised at 15 deg C for 15 min; bacterial luminescence meas. before title comp. addition (0 min) then 5 and 15 min after title comp. addition

Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

6.561 - 6.958 percent v/v

Cassells; Lane; Depala; Saeed; Craston; Chemosphere; vol. 40; nb. 6; (2000); p. 609 - 618, View in Reaxys 68 of 142

Effect (Ecotoxicology)

toxicity to bacteria

Endpoint of Effect (Ecotoxicology)

growth inhibition

Species or Test-System (Ecotoxicology)

Vibrio fischeri DSMZ 7151/NRRLB-11177

20/42

2016-05-10 05:50:17

Kind of Dosing (Ecotoxi- title comp. dissolved in distilled water; adjusted to pH 7 and salinity of 2 percent NaCl cology) Method (Ecotoxicology)

chronic toxicity tests; bacterial cultures incub. for 6 h at 20 deg C; on microplates in iEMS incubator; continuously agitated at 1150 rpm; cell conc. determ. by photometrically determining turbidity

Type (Ecotoxicology)

LO(A)EC

Value of Type (Ecotoxicology)

3990 mg/l

Gellert, Georg; Ecotoxicology and Environmental Safety; vol. 45; nb. 1; (2000); p. 87 - 91, View in Reaxys 69 of 142

Effect (Ecotoxicology)

toxicity to bacteria

Endpoint of Effect (Ecotoxicology)

growth inhibition

Species or Test-System (Ecotoxicology)

Vibrio fischeri DSMZ 7151/NRRLB-11177

Kind of Dosing (Ecotoxi- title comp. dissolved in distilled water; adjusted to pH 7 and salinity of 2 percent NaCl cology) Method (Ecotoxicology)

chronic toxicity tests; bacterial cultures incub. for 6 h at 20 deg C; on microplates in iEMS incubator; continuously agitated at 1150 rpm; cell conc. determ. by photometrically determining turbidity

Type (Ecotoxicology)

EC20

Value of Type (Ecotoxicology)

8820 μg/l

Gellert, Georg; Ecotoxicology and Environmental Safety; vol. 45; nb. 1; (2000); p. 87 - 91, View in Reaxys 70 of 142

Effect (Ecotoxicology)

toxicity to aquatic invertebrates (acute)

Endpoint of Effect (Ecotoxicology)

lethality

Species or Test-System (Ecotoxicology)

Daphnia magna

Kind of Dosing (Ecotoxi- title comp. dissolved in nanopure water; diluted with ASTM hard water cology) Exposure Period (Ecotoxicology)

24 - 48 h

Method (Ecotoxicology)

3rd-5th brood neonates (<24 h old); ASTM hard water (ASTM, 1980); 20 deg C; 16:8 h light:dark cycle; no feeding during test

Further Details (Ecotoxi- clone A animals used; measured effect was death recognized as immobilization for 15 s cology) after stimulation by bright light Type (Ecotoxicology)

LC50

Value of Type (Ecotoxicology)

3289 - 4816 mg/l

Guilhermino, Lucia; Diamantino, Teresa; Carolina Silva; Soares; Ecotoxicology and Environmental Safety; vol. 46; nb. 3; (2000); p. 357 - 362, View in Reaxys 71 of 142

Effect (Ecotoxicology)

toxicity to bacteria

Species or Test-System (Ecotoxicology)

Aspergillus niger WU-2223L

Concentration (Ecotoxicology)

2 percent v/v

Method (Ecotoxicology)

in vitro; synthetic medium amended with glucose; after 5-9 d incub. mycelia harvest.; mycelial growth assessed; respiration rate, duroquinol oxidase activity and citric acid production rate determ.

Further Details (Ecotoxi- SHAM = salicylhydroxamic acid cology)

21/42

2016-05-10 05:50:17

Results

SHAM sensitivity in respiration drastically increased; 2-fold increase in duroquinol oxidase activity; no repression of mycelial growth; citric acid production and productivity signif. increased

Kirimura, Kohtaro; Yoda, Masashi; Shimizu, Hideki; Sugano, Shuji; Mizuno, Makoto; Kino, Kuniki; Usami, Shoji; Bioscience, Biotechnology and Biochemistry; vol. 64; nb. 10; (2000); p. 2034 - 2039, View in Reaxys 72 of 142

Effect (Ecotoxicology)

metabolic

Endpoint of Effect (Ecotoxicology)

title comp. utilization; growth of bacteria

Species or Test-System (Ecotoxicology)

waste sludge

Kind of Dosing (Ecotoxi- title comp. in composition of synthetic condensate (mg/l): title comp., 500; dimethyl sulcology) phide, 37; dimethyl disulphide, 25 Method (Ecotoxicology)

title comp. was incub. with waste sludge in high temperature membrane bioreactor (MBR) at 55, 60, 65, or 70 deg C for up to 170 min at pH 6.0-6.5; cumulative mass of organisms and title comp. conc. were measured

Further Details (Ecotoxi- activated waste sludge was obtained from Western pulp mill; specific utilization coefficient cology) (SUC); specific growth coefficient (SGC) Results

diagrams of SUC and CGS dependence on temp. have been pres.; maximum SUC and SGC (0.81 1/day and 0.13 1/day) were obs. at 60 deg C and declined sharply at higher temperatures

Berube; Hall; Water Research; vol. 34; nb. 18; (2000); p. 4359 - 4366, View in Reaxys 73 of 142

Effect (Ecotoxicology)

toxicity to invertebrates

Species or Test-System (Ecotoxicology)

Spirostomum ambiguum, protozoa

Concentration (Ecotoxicology)

1 - 10 percent

Exposure Period (Ecotoxicology)

24 - 48 h

Method (Ecotoxicology)

Spirotox test, polystyrene microplates, pH 7.4, hardness 2.8 mg CaCO3/l, incubation in the darkness 25 deg C

Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

549 - 733 mmol/l

Results

test comp. caused different deformations of cells

Nalecz-Jawecki, Grzegorz; Sawicki, Jozef; Chemosphere; vol. 38; nb. 14; (1999); p. 3211 - 3218, View in Reaxys 74 of 142

Effect (Ecotoxicology)

toxicity to invertebrates

Species or Test-System (Ecotoxicology)

Spirostomum ambiguum, protozoa

Concentration (Ecotoxicology)

1 - 10 percent

Exposure Period (Ecotoxicology)

24 - 48 h

Method (Ecotoxicology)

Spirotox test, polystyrene microplates, pH 7.4, hardness 2.8 mg CaCO3/l, incubation in the darkness 25 deg C

Type (Ecotoxicology)

LC50

Value of Type (Ecotoxicology)

1149 - 1167 mmol/l

Nalecz-Jawecki, Grzegorz; Sawicki, Jozef; Chemosphere; vol. 38; nb. 14; (1999); p. 3211 - 3218, View in Reaxys 75 of 142

Effect (Ecotoxicology)

genotoxicity

Species or Test-System (Ecotoxicology)

Methylobacterium sp. DM4-2cr (GSTT1)

22/42

2016-05-10 05:50:17

Concentration (Ecotoxicology)

40 mmol/l

Exposure Period (Ecotoxicology)

50 - 110 h

Method (Ecotoxicology)

growth in gas-tight flasks

Further Details (Ecotoxi- 30 deg C; cology) Results

growth rate: 0.112 h-1

Gisi, Daniel; Leisinger, Thomas; Vuilleumier, Stephane; Archives of Toxicology; vol. 73; nb. 2; (1999); p. 71 - 79, View in Reaxys 76 of 142

Effect (Ecotoxicology)

genotoxicity

Species or Test-System (Ecotoxicology)

Methylobacterium sp. DM4-2cr (DM11)

Concentration (Ecotoxicology)

40 mmol/l

Exposure Period (Ecotoxicology)

50 - 110 h

Method (Ecotoxicology)

growth in gas-tight flasks

Further Details (Ecotoxi- 30 deg C; cology) Results

growth rate: 0.124 h-1

Gisi, Daniel; Leisinger, Thomas; Vuilleumier, Stephane; Archives of Toxicology; vol. 73; nb. 2; (1999); p. 71 - 79, View in Reaxys 77 of 142

Effect (Ecotoxicology)

cytotoxicity

Species or Test-System (Ecotoxicology)

rainbow trout gill epithelial cells

Exposure Period (Ecotoxicology)

6-8d

Method (Ecotoxicology)

in vitro; primary cultures; cells were isolated from rainbow trout (mean weight of about 60 g); brought to suspension after 6-8 days in primary culture

Further Details (Ecotoxi- 18 deg C; incubation open to the air; fluorescent viability probe calcein-AM cology) Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

4570 - 4967 mM

Results

no significant difference in sensitivity of gill epithelial cells in suspension, primary cultures or resuspended cells

Sandbacka; Paert; Isomaa; Aquatic Toxicology; vol. 46; nb. 1; (1999); p. 23 - 32, View in Reaxys 78 of 142

Effect (Ecotoxicology)

toxicity to bacteria

Endpoint of Effect (Ecotoxicology)

bioluminescence

Species or Test-System (Ecotoxicology)

Stenotrophomonas 3664

Exposure Period (Ecotoxicology)

5 - 15 min

Method (Ecotoxicology)

Microtox test; vehicle water, 25 deg C

Results

log(IC50)-1 -3.09-3.07 mM

Layton; Gregory; Schultz; Sayler; Ecotoxicology and Environmental Safety; vol. 43; nb. 2; (1999); p. 222 - 228, View in Reaxys 79 of 142

Effect (Ecotoxicology)

toxicity to bacteria

23/42

2016-05-10 05:50:17

Endpoint of Effect (Ecotoxicology)

bioluminescence

Species or Test-System (Ecotoxicology)

Alcaligenes eutropus 2050

Exposure Period (Ecotoxicology)

5 - 15 min

Method (Ecotoxicology)

Microtox test; vehicle water, 25 deg C

Results

log(IC50)-1 -3.38 mM

Layton; Gregory; Schultz; Sayler; Ecotoxicology and Environmental Safety; vol. 43; nb. 2; (1999); p. 222 - 228, View in Reaxys 80 of 142

Effect (Ecotoxicology)

toxicity to bacteria

Endpoint of Effect (Ecotoxicology)

bioluminescence

Species or Test-System (Ecotoxicology)

Vibrio fischeri

Exposure Period (Ecotoxicology)

5 - 15 min

Method (Ecotoxicology)

Microtox test; vehicle saline, 25 deg C

Results

log (IC50)-1 -3.29-3.27 mM

Layton; Gregory; Schultz; Sayler; Ecotoxicology and Environmental Safety; vol. 43; nb. 2; (1999); p. 222 - 228, View in Reaxys 81 of 142

Effect (Ecotoxicology)

toxicity to invertebrates

Endpoint of Effect (Ecotoxicology)

mortality

Species or Test-System (Ecotoxicology)

Calliphora vomitoria, flesh bluebottle

Route of Application

inhalation

Method (Ecotoxicology)

groups of 30 larvae in two developmental stages (larva-pupa and pupa-hatching) exposed to vapor of title comp. in airtight glass vessel at 20 deg C; atmosphere renewed every 5 days; exp. time = time of 100 percent pupation/hatching (5-8/20-30 days) in controls

Further Details (Ecotoxi- LC50 calculated using Spearman-Karber method cology) Type (Ecotoxicology)

LC50

Value of Type (Ecotoxicology)

3.465 - 10.028 mg/l

Lello; Nieri; Bulletin of Environmental Contamination and Toxicology; vol. 63; nb. 5; (1999); p. 660 - 664, View in Reaxys 82 of 142

Effect (Ecotoxicology)

toxicity to bacteria

Species or Test-System (Ecotoxicology)

Vibrio fischeri

Exposure Period (Ecotoxicology)

15 min

Method (Ecotoxicology)

in vitro; Microtox bioassay, pH 7.3

Type (Ecotoxicology)

log(1/EC50)

Value of Type (Ecotoxicology)

3.26 mmol/l

Gustavson, Karl E.; Svenson, Anders; Harkin, John M.; Environmental Toxicology and Chemistry; vol. 17; nb. 10; (1998); p. 1917 - 1921, View in Reaxys 83 of 142

Effect (Ecotoxicology)

toxicity to other terrestrial species (non-mammalian)

24/42

2016-05-10 05:50:17

Species or Test-System (Ecotoxicology)

vesicular-arbuscular mycorrhizae

Concentration (Ecotoxicology)

1000 - 50000 ppm

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

mycorrhizae in Ri t-DNA-transformed Daucus carota L. carrot roots by Glomus intraradices, colonization determination

Results

reduced colonization of carrot roots at 50000 ppm

Wan, Michael T.; Rahe, James E.; Environmental Toxicology and Chemistry; vol. 17; nb. 10; (1998); p. 2041 2050, View in Reaxys 84 of 142

Effect (Ecotoxicology)

plant growth

Species or Test-System (Ecotoxicology)

Daucus carota L.

Concentration (Ecotoxicology)

2500 - 50000 ppm

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

growth of Ri t-DNA-transformed carrot roots observation

Results

root growth inhibited at 50000 ppm

Wan, Michael T.; Rahe, James E.; Environmental Toxicology and Chemistry; vol. 17; nb. 10; (1998); p. 2041 2050, View in Reaxys 85 of 142

Effect (Ecotoxicology)

toxicity to other terrestrial species (non-mammalian)

Endpoint of Effect (Ecotoxicology)

extraradical mycelial growth

Species or Test-System (Ecotoxicology)

Glomus intraradices

Exposure Period (Ecotoxicology)

14 - 30 d

Method (Ecotoxicology)

sublethal test; incubated on test comp.-treated minimal medium aged for 0 and 30 d, 27 deg C

Type (Ecotoxicology)

IC50

Value of Type (Ecotoxicology)

10000 - 14800 ppm

Wan, Michael T.; Rahe, James E.; Environmental Toxicology and Chemistry; vol. 17; nb. 10; (1998); p. 2041 2050, View in Reaxys 86 of 142

Effect (Ecotoxicology)

toxicity to other terrestrial species (non-mammalian)

Endpoint of Effect (Ecotoxicology)

extraradical mycelial growth

Species or Test-System (Ecotoxicology)

Glomus intraradices

Exposure Period (Ecotoxicology)

14 - 30 d

Method (Ecotoxicology)

sublethal test; incubated on test comp.-treated minimal medium aged for 0 and 30 d, 27 deg C

Type (Ecotoxicology)

IC50

Value of Type (Ecotoxicology)

16000 ppm

Wan, Michael T.; Rahe, James E.; Environmental Toxicology and Chemistry; vol. 17; nb. 10; (1998); p. 2041 2050, View in Reaxys 87 of 142

Effect (Ecotoxicology)

embryotoxicity

25/42

2016-05-10 05:50:17

Endpoint of Effect (Ecotoxicology)

mortality

Species or Test-System (Ecotoxicology)

Artemia salina

Concentration (Ecotoxicology)

0.5 mol/l

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

cysts, 27 deg C, twelve-well multiwell plates

Type (Ecotoxicology)

LC50

Value of Type (Ecotoxicology)

1.50 mol/l

Vismara, Claudio; Chemosphere; vol. 37; nb. 14-15; (1998); p. 3027 - 3034, View in Reaxys 88 of 142

Effect (Ecotoxicology)

embryotoxicity

Endpoint of Effect (Ecotoxicology)

mortality

Species or Test-System (Ecotoxicology)

Artemia salina

Concentration (Ecotoxicology)

0.5 mol/l

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

cysts, 27 deg C, twelve-well multiwell plates

Type (Ecotoxicology)

LC5

Value of Type (Ecotoxicology)

0.68 mol/l

Vismara, Claudio; Chemosphere; vol. 37; nb. 14-15; (1998); p. 3027 - 3034, View in Reaxys 89 of 142

Effect (Ecotoxicology)

embryotoxicity

Endpoint of Effect (Ecotoxicology)

mortality

Species or Test-System (Ecotoxicology)

Artemia salina

Concentration (Ecotoxicology)

0.5 mol/l

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

cysts, 27 deg C, twelve-well multiwell plates

Type (Ecotoxicology)

LC1

Value of Type (Ecotoxicology)

0.56 mol/l

Vismara, Claudio; Chemosphere; vol. 37; nb. 14-15; (1998); p. 3027 - 3034, View in Reaxys 90 of 142

Effect (Ecotoxicology)

embryotoxicity

Endpoint of Effect (Ecotoxicology)

growth inhibition

Species or Test-System (Ecotoxicology)

Artemia salina

Concentration (Ecotoxicology)

0.5 mol/l

Exposure Period (Ecotoxicology)

26/42

2016-05-10 05:50:17

Method (Ecotoxicology)

cysts, 27 deg C, twelve-well multiwell plates

Type (Ecotoxicology)

GI1

Value of Type (Ecotoxicology)

0.21 mol/l

Vismara, Claudio; Chemosphere; vol. 37; nb. 14-15; (1998); p. 3027 - 3034, View in Reaxys 91 of 142

Effect (Ecotoxicology)

embryotoxicity

Endpoint of Effect (Ecotoxicology)

growth inhibition

Species or Test-System (Ecotoxicology)

Artemia salina

Concentration (Ecotoxicology)

0.5 mol/l

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

cysts, 27 deg C, twelve-well multiwell plates

Type (Ecotoxicology)

GI5

Value of Type (Ecotoxicology)

0.37 mol/l

Vismara, Claudio; Chemosphere; vol. 37; nb. 14-15; (1998); p. 3027 - 3034, View in Reaxys 92 of 142

Effect (Ecotoxicology)

embryotoxicity

Endpoint of Effect (Ecotoxicology)

growth inhibition

Species or Test-System (Ecotoxicology)

Artemia salina

Concentration (Ecotoxicology)

0.5 mol/l

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

cysts, 27 deg C, twelve-well multiwell plates

Type (Ecotoxicology)

GI50

Value of Type (Ecotoxicology)

1.46 mol/l

Vismara, Claudio; Chemosphere; vol. 37; nb. 14-15; (1998); p. 3027 - 3034, View in Reaxys 93 of 142

Effect (Ecotoxicology)

toxicity to terrestrial plants

Species or Test-System (Ecotoxicology)

Daucus carota, carrot

Concentration (Ecotoxicology)

1200 - 50000 ppm

Exposure Period (Ecotoxicology)

28 d

Method (Ecotoxicology)

DNA (Ri T-DNA)-transformed carrot roots; M-medium; inoculated with VAM fungus Glomus intraradices; in dark; 27 deg C; root growth; biomass and VAM colonization ( percent)

Results

no effect on Ri T-DNA-transformed roots and root biomass below 50000 ppm of test comp.; root elongation suppress. and root dry weight signif. reduc. at 50000 ppm; VAM development severely reduced at 50000 ppm

Wan, Michael T.; Rahe, James E.; Watts, Ronald G.; Environmental Toxicology and Chemistry; vol. 17; nb. 7; (1998); p. 1421 - 1428, View in Reaxys 94 of 142

Effect (Ecotoxicology)

antifungal

Species or Test-System (Ecotoxicology)

Glomus intraradices, fungus

27/42

2016-05-10 05:50:17

Exposure Period (Ecotoxicology)

14 d

Method (Ecotoxicology)

static nonrenewable test; M-medium system; pH 5.8; 100x15 cm petri dishes; in dark; 27 deg Cextraradical mycelial growth (EMG); EC50 of extraradical mycelial sporulation (EMS) also, nonlinear regression and linear interpolation values

Type (Ecotoxicology)

IC50

Value of Type (Ecotoxicology)

14200 - 14800 ppm

Results

EMS IC50: 1900-3400 ppm

Wan, Michael T.; Rahe, James E.; Watts, Ronald G.; Environmental Toxicology and Chemistry; vol. 17; nb. 7; (1998); p. 1421 - 1428, View in Reaxys 95 of 142

Effect (Ecotoxicology)

toxicity to terrestrial plants

Species or Test-System (Ecotoxicology)

maize

Concentration (Ecotoxicology)

0.01 - 1000 μmol/l

Kind of Dosing (Ecotoxi- test comp. dissolv. in water cology) Exposure Period (Ecotoxicology)

12 h

Method (Ecotoxicology)

growth exper.; 72-96-h old maize seedlings; sized accord. to length of primary root; incub. on circles of filter paper moisten. with 3 ml of solution; contain. in petri dishes

Results

root growth stimulated at 1E-8 M and inhibited and higher conc.

Morre; Human and Experimental Toxicology; vol. 17; nb. 5; (1998); p. 272 - 277, View in Reaxys 96 of 142

Effect (Ecotoxicology)

metamorphosis, inhibition of

Species or Test-System (Ecotoxicology)

Hydractinia echinata, larvae

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

larvae exposed to seawater containing 2.5 mM Mg(2+)

Further Details (Ecotoxi- MRC50 - concentration reduced the metamorphosis induction by 50 percent cology) Type (Ecotoxicology)

log MRC50

Value of Type (Ecotoxicology)

0.20 not given

Chicu; Berking; Chemosphere; vol. 34; nb. 8; (1997); p. 1851 - 1866, View in Reaxys 97 of 142

Effect (Ecotoxicology)

metamorphosis, inhibition of

Species or Test-System (Ecotoxicology)

Hydractinia echinata, larvae

Concentration (Ecotoxicology)

3 - 100 μl/ml

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

larvae exposed to seawater containing 20 mM CsCl

Further Details (Ecotoxi- MRC50 - concentration reduced the metamorphosis induction by 50 percent cology) Type (Ecotoxicology)

log MRC50

Value of Type (Ecotoxicology)

0.22 not given

Chicu; Berking; Chemosphere; vol. 34; nb. 8; (1997); p. 1851 - 1866, View in Reaxys

28/42

2016-05-10 05:50:17

98 of 142

Effect (Ecotoxicology)

toxicity to invertebrates

Species or Test-System (Ecotoxicology)

Drosophila melanogaster strain ORR-flr3/TM3, fruitfly

Sex

male and female

Route of Application

inhalation

Concentration (Ecotoxicology)

1000 - 124000 ppm

Method (Ecotoxicology)

overall metabolism determined; CO2 production measurements during narcosis; correlation of body activities and CO2 production during recovery phase analysis; title compound incubated for 10-15 min

Further Details (Ecotoxi- T: 22.5 deg C; usually 16 flies used (8 males and 8 females); applied to the filter paper; cology) also under saturating conditions Results

length of narcosis correlated well with octanol-water coefficient; title comp. did not promote narcosis; no signs of hyperactivity; dose-dependent CO2 emission diagrams

Wasserkort, Reinhold; Koller, Theodor; Journal of Applied Toxicology; vol. 17; nb. 2; (1997); p. 119 - 125, View in Reaxys 99 of 142

Effect (Ecotoxicology)

current; inhibition of

Species or Test-System (Ecotoxicology)

Lymnaea stagnalis neuron

Concentration (Ecotoxicology)

< 10 mol/l

Method (Ecotoxicology)

neurons treated with title comp.; Iaf examined using microscopic recording techniques (step depolarization were -20 mV)

Further Details (Ecotoxi- Kd: title comp. conc. produced 50 percent current inhibition; Iaf: fast-inactivating potassium cology) A-current Type (Ecotoxicology)

Value of Type (Ecotoxicology)

2970 mmol/l

Results

title comp. produced reversible blockade of current and selectively affected inactivation mechanism; steady-state inactivation, voltage dependence of inactivation and activation kinetics of Iaf were largely unaffected by title comp.

Alekseev; Ziskin; Journal of Pharmacology and Experimental Therapeutics; vol. 281; nb. 1; (1997); p. 84 - 92, View in Reaxys 100 of 142 Effect (Ecotoxicology)

toxicity to aquatic plants

Endpoint of Effect (Ecotoxicology)

growth

Species or Test-System (Ecotoxicology)

Chlorella vulgaris, alga

Exposure Period (Ecotoxicology)

13 d

Method (Ecotoxicology)

culture in Bold's Basal Medium (BBM);exposure by adding 1 ml of 1 g l-1 HCB solution in methanol per 1 l of culture medium; initial cell density: 2.37E6 cells ml-1; cell number count in counting chamber

Further Details (Ecotoxi- at 25+/-1 deg C; 16h light:8 h dark photoperiod cology) Comment (Ecotoxicology)

No effect

Munoz, Maria J.; Ramos, Carmen; Tarazona, Jose V.; Aquatic Toxicology; vol. 35; nb. 3-4; (1996); p. 211 - 220, View in Reaxys 101 of 142 Effect (Ecotoxicology) Endpoint of Effect (Ecotoxicology)

toxicity to aquatic invertebrates (acute) immobility

29/42

2016-05-10 05:50:17

Species or Test-System (Ecotoxicology)

Daphnia obtusa, cladoceran

Exposure Period (Ecotoxicology)

24 h

Method (Ecotoxicology)

static acute toxicity test; 10 neonates (less than 24 h old) in 20 mL of test solution (dilution water with added toxicant); measuring immobility after the exposure period; estimation of EC50 by means of the best-fit dose-response curve

Further Details (Ecotoxi- the organisms were obtained from 1 single animals; culture medium: synthetic fresh wacology) ter; pH 7.8+/-0.2; hardness 250 mg/L of CaCO3; at 20+/-2 deg C; light intensity of 1000 lux; 16:8 light:darkness period Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

23500 mg/l

Bulus Rossini, Gustave D.; Environmental Toxicology and Water Quality; vol. 11; nb. 3; (1996); p. 255 - 258, View in Reaxys 102 of 142 Effect (Ecotoxicology)

toxicity to aquatic invertebrates (acute)

Endpoint of Effect (Ecotoxicology)

immobility

Species or Test-System (Ecotoxicology)

Daphnia obtusa, cladoceran

Exposure Period (Ecotoxicology)

48 h

Method (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

22200 mg/l

Bulus Rossini, Gustave D.; Environmental Toxicology and Water Quality; vol. 11; nb. 3; (1996); p. 255 - 258, View in Reaxys 103 of 142 Effect (Ecotoxicology)

toxicity to bacteria

Species or Test-System (Ecotoxicology)

Photobacterium phosphoreum, bacterium

Exposure Period (Ecotoxicology)

15 min

Method (Ecotoxicology)

Microtox testing according to Microbics Corporation recommendations

Further Details (Ecotoxi- determination of EC50 value and dose-response relationships as a slope of the curve cology) Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

48800 mg/l

Chung-Yuan, Chen; Ch'i-Feng, Huang; Environmental Toxicology and Chemistry; vol. 15; nb. 9; (1996); p. 1464 1469, View in Reaxys 104 of 142 Effect (Ecotoxicology)

toxicity to aquatic plants

Endpoint of Effect (Ecotoxicology)

growth

Species or Test-System (Ecotoxicology)

natural phytoplankton

30/42

2016-05-10 05:50:17

Concentration (Ecotoxicology)

0.05 percent

Exposure Period (Ecotoxicology)

100 h

Method (Ecotoxicology)

phytoplankton collected from the light-saturated layer of the Lake Geneva, France-Switzerland; Sep. and Oct 1994 (exp. 1 and 2, resp.); phytoplankton taxa; community composition diversity parameter (H'); Shannon-Weaver equation

Further Details (Ecotoxi- temp. 20 deg C; constant illumination; light intensity 1.2E16 quanta cm-2 s-1 cology) Results

no effect on total growth; diversity index (conc. 0.05 percent; bits/cell) in exp. 1: 2.40 (control 2.49), exp. 2: 3.78 (control 3.85)

Berard; Bulletin of Environmental Contamination and Toxicology; vol. 57; nb. 2; (1996); p. 183 - 190, View in Reaxys 105 of 142 Effect (Ecotoxicology)

toxicity to aquatic plants

Endpoint of Effect (Ecotoxicology)

growth inhibition

Species or Test-System (Ecotoxicology)

Chlorella vulgaris, green algae

Concentration (Ecotoxicology)

0.05 - 1 percent

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

chlorophyll (a) content

Further Details (Ecotoxi- temp. 21 deg C; continuous illumination, 100 μE*m-2*sec-1; aerated water; growth curve cology) Results

33-83 percent inhibition at conc. 0.2-1 percent on day 4

El Jay; Bulletin of Environmental Contamination and Toxicology; vol. 57; nb. 2; (1996); p. 191 - 198, View in Reaxys 106 of 142 Effect (Ecotoxicology)

toxicity to aquatic plants

Endpoint of Effect (Ecotoxicology)

growth inhibition

Species or Test-System (Ecotoxicology)

Selenastrum capricornutum (Printz), green algae

Concentration (Ecotoxicology)

0.05 - 1 percent

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

chlorophyll (a) content

Further Details (Ecotoxi- temp. 21 deg C; continuous illumination, 100 μE*m-2*sec-1; aerated water; growth curve cology) Results

21-42 percent inhibition at conc. 0.2-1 percent on day 4

El Jay; Bulletin of Environmental Contamination and Toxicology; vol. 57; nb. 2; (1996); p. 191 - 198, View in Reaxys 107 of 142 Effect (Ecotoxicology)

toxicity to aquatic invertebrates (acute)

Species or Test-System (Ecotoxicology)

Mytilus edulis, blue mussel

Concentration (Ecotoxicology)

1 - 10 percent v/v

Exposure Period (Ecotoxicology)

96 h

Method (Ecotoxicology)

mussels collected from Narragansett Bay in early January 1993; fed a unicellular algae Isochrysis galbana T-Iso; Narragansett Gay seawater (DO 7.0-7.3 mg/l, pH 7.6-8.2, salinity 29-31 g/kg); temp. 15 deg C

31/42

2016-05-10 05:50:17

Further Details (Ecotoxi- statistical methods: Trimmed Spearman-Karber method (TSK) and Inhibiton Concentration cology) Percentage method (ICp) Type (Ecotoxicology)

LC50

Value of Type (Ecotoxicology)

15900 mg/l

Results

TSK method: LC50 = 1.92 percent, equivalent to 15200 mg/l; ICp method: LC50 = 2.10 percent, equivalent to 16700 mg/l; sublethal effects (e.g., narcosis) were observed for exposure conc. of 2-3 percent MeOH

Helmstetter; Gamerdinger; Pruell; Bulletin of Environmental Contamination and Toxicology; vol. 57; nb. 4; (1996); p. 675 - 681, View in Reaxys 108 of 142 Effect (Ecotoxicology)

toxicity to aquatic invertebrates (acute)

Species or Test-System (Ecotoxicology)

Mytilus edulis, blue mussel

Concentration (Ecotoxicology)

1 - 10 percent v/v

Exposure Period (Ecotoxicology)

96 h

Method (Ecotoxicology)

Further Details (Ecotoxi- statistical methods: Trimmed Spearman-Karber method (TSK) and Inhibiton Concentration cology) Percentage method (ICp) Type (Ecotoxicology)

NO(A)EC

Value of Type (Ecotoxicology)

7960 mg/l

Helmstetter; Gamerdinger; Pruell; Bulletin of Environmental Contamination and Toxicology; vol. 57; nb. 4; (1996); p. 675 - 681, View in Reaxys 109 of 142 Effect (Ecotoxicology)

toxicity to aquatic invertebrates (acute)

Endpoint of Effect (Ecotoxicology)

mortality

Species or Test-System (Ecotoxicology)

Mytilus edulis, blue mussel

Concentration (Ecotoxicology)

1 - 10 percent v/v

Exposure Period (Ecotoxicology)

13.5 - 96 h

Method (Ecotoxicology)

Results

100 percent mortality at 5 and 10 percent after 13.5 h, and at 3 percent after 89 h; 8 of the 18 mussels in the 2 percent treatment were dead after 96 h; no effect at 1 percent

Helmstetter; Gamerdinger; Pruell; Bulletin of Environmental Contamination and Toxicology; vol. 57; nb. 4; (1996); p. 675 - 681, View in Reaxys 110 of 142

Effect (Ecotoxicology)

behavioral symtoms

Endpoint of Effect (Ecotoxicology)

attraction

Species or Test-System (Ecotoxicology)

Diabrotica virgifera virgifera, western corn rootworm

Concentration (Ecotoxicology)

0.5 - 4.0 mg

Exposure Period (Ecotoxicology)

30 min

32/42

2016-05-10 05:50:17

Method (Ecotoxicology)

second-instar larvae (5-7 days old, 4-7 mm long); two-choice bioassay; 23-27 deg C

Comment (Ecotoxicology)

No effect

Jewett; Bjostad; Journal of Chemical Ecology; vol. 22; nb. 7; (1996); p. 1331 - 1344, View in Reaxys 111 of 142

Effect (Ecotoxicology)

toxicity to aquatic invertebrates (acute)

Endpoint of Effect (Ecotoxicology)

bioluminescence

Species or Test-System (Ecotoxicology)

Vibrio harveyi

Exposure Period (Ecotoxicology)

24 h

Method (Ecotoxicology)

direct toxicity assay; mixture 3 g soil, 600 or 60 μl title comp. stock solution, 5.4 or 5.9 ml water; soil without pretreatment 0.2 N HCl; incubated 24 h at 20-25 deg C; measured reduce bioluminescence

Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

10000 ppm

Thomulka; Lange; Ecotoxicology and Environmental Safety; vol. 32; nb. 2; (1995); p. 201 - 204, View in Reaxys 112 of 142

Effect (Ecotoxicology)

toxicity to aquatic invertebrates (acute)

Endpoint of Effect (Ecotoxicology)

bioluminescence

Species or Test-System (Ecotoxicology)

Vibrio harveyi

Exposure Period (Ecotoxicology)

24 h

Method (Ecotoxicology)

direct toxicity assay; mixture 3 g soil, 600 or 60 μl title comp. stock solution, 5.4 or 5.9 ml water; soil with pretreatment 0.2 N HCl; incubated 24 h at 20-25 deg C; measured reduce bioluminescence

Type (Ecotoxicology)

EC20

Value of Type (Ecotoxicology)

10000 ppm

Thomulka; Lange; Ecotoxicology and Environmental Safety; vol. 32; nb. 2; (1995); p. 201 - 204, View in Reaxys 113 of 142

Effect (Ecotoxicology)

microorganisms

Species or Test-System (Ecotoxicology)

heterotrophic anaerobic microorganisms

Concentration (Ecotoxicology)

10 - 30 mg/l

Exposure Period (Ecotoxicology)

0 - 60 d

Method (Ecotoxicology)

direct epifluorescence counting technique, the DAPI method; bacterial cell numbers determination; microscopic study of morphology

Further Details (Ecotoxi- culture from the anaerobic digester of the Taiwan Sugar Co. wastewater treatment facility cology) (Hsinchu, Taiwan) Results

a 2- to 4-folds increase of bacterial cell numbers in 30 days with 10 mg/L of chemicals; a 3- to 5-folds increase with 30 mg/L of chemicals; decrease of microbial activities on day 60; different morphologies of bacteria were present

Doong, Ruey-an; Wu, Shian-chee; Chemosphere; vol. 30; nb. 8; (1995); p. 1499 - 1512, View in Reaxys 114 of 142

Effect (Ecotoxicology)

toxicity to aquatic invertebrates

Endpoint of Effect (Ecotoxicology)

immobilization

33/42

2016-05-10 05:50:17

Species or Test-System (Ecotoxicology)

Daphnia pulex

Exposure Period (Ecotoxicology)

24 h

Method (Ecotoxicology)

toxicity test in standard reference water (SRW) according to the OECD standard protocol; different concentrations of test chemical (50 ml liquid in vessel); immobilization was determined visually

Further Details (Ecotoxi- < 24 h neonates; SRW: 2.4 mM NaHCO3, 0.15 mM K2SO4, 2.0 mM CaCl2, 0.01 mM cology) KH2PO4, pH 7.6 Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

857.3 mmol/l

Lilius, Henrik; Haestbacka, Tom; Isomaa, Boris; Environmental Toxicology and Chemistry; vol. 14; nb. 12; (1995); p. 2085 - 2088, View in Reaxys 115 of 142

Effect (Ecotoxicology)

toxicity to aquatic invertebrates

Endpoint of Effect (Ecotoxicology)

immobilization

Species or Test-System (Ecotoxicology)

Daphnia magna

Exposure Period (Ecotoxicology)

24 h

Method (Ecotoxicology)

toxicity test in standard reference water (SRW) according to the OECD standard protocol; different concentrations of test chemical (50 ml liquid in vessel); immobilization was determined visually

Further Details (Ecotoxi- < 24 h neonates; SRW: 2.4 mM NaHCO3, 0.15 mM K2SO4, 2.0 mM CaCl2, 0.01 mM cology) KH2PO4, pH 7.6 Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

649.3 mmol/l

Lilius, Henrik; Haestbacka, Tom; Isomaa, Boris; Environmental Toxicology and Chemistry; vol. 14; nb. 12; (1995); p. 2085 - 2088, View in Reaxys 116 of 142

Effect (Ecotoxicology)

toxicity to fish

Species or Test-System (Ecotoxicology)

Oncorhynchus mykiss, rainbow trout

Concentration (Ecotoxicology)

4000 μg/l

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

BioSensor cell, model 6008A; electronic biomonitoring unit; measurement variety of stress responses: ventilation rates (frequency and amplitude), swimming patterns and general activity; visually observed presence or absence of response

Results

values of frequency and amplitude of ventilation rate; absence of brief and sustained responses

Kaiser, Klaus L. E.; McKinnon, Mark B.; Stendahl, Douglas H.; Pett, W. Brian; Environmental Toxicology and Chemistry; vol. 14; nb. 12; (1995); p. 2107 - 2114, View in Reaxys 117 of 142

Effect (Ecotoxicology)

toxicity to bacteria

Species or Test-System (Ecotoxicology)

Microtox test

Exposure Period (Ecotoxicology)

15 min

Method (Ecotoxicology)

Microtox test; standard procedure recommended by the Microbics Corporation; Probit Model

34/42

2016-05-10 05:50:17

Further Details (Ecotoxi- Microtox model M500 analyzer; 6 different concentrations; mean EC50 (n=1) cology) Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

48269.0 mg/l

Chen; Chiou; Environmental Toxicology and Water Quality; vol. 10; nb. 2; (1995); p. 97 - 106, View in Reaxys 118 of 142

Effect (Ecotoxicology)

toxicity to bacteria

Species or Test-System (Ecotoxicology)

Microtox test

Exposure Period (Ecotoxicology)

15 min

Method (Ecotoxicology)

Microtox test; standard procedure recommended by the Microbics Corporation; Weibull Model

Further Details (Ecotoxi- Microtox model M500 analyzer; 6 different concentrations; mean EC50 (n=1) cology) Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

51211.0 mg/l

Chen; Chiou; Environmental Toxicology and Water Quality; vol. 10; nb. 2; (1995); p. 97 - 106, View in Reaxys 119 of 142

Effect (Ecotoxicology)

toxicity to bacteria

Species or Test-System (Ecotoxicology)

Pseudomonas putida S12

Method (Ecotoxicology)

strain cult. in mineral medium with glucose; cells grown in 100 ml shake cultures in horizont. shaking water bath at 30 deg C; growth in fresh med.; after 4 h title comp. added; growth meas. by monitor. turbidity of cell susp. used spectrophotometer

Further Details (Ecotoxi- growth inh. measured by comp. differences in growth rates between toxicated cultures cology) with control; LD 50 - 50 percent growth inh. Type (Ecotoxicology)

LD50

Value of Type (Ecotoxicology)

1480.0 mmol/l

Results

direct relationship between changes in trans/cis ratios of membrane lipids and growth inhibition shown

Heipieper, Hermann J.; Loffeld, Burkhard; Keweloh, Heribert; Bont, Jan A. M. de; Chemosphere; vol. 30; nb. 6; (1995); p. 1041 - 1052, View in Reaxys 120 of 142 Effect (Ecotoxicology)

microorganisms

Species or Test-System (Ecotoxicology)

Pseudomonas putida S12

Method (Ecotoxicology)

strain cult. in mineral medium with glucose; cells grown in 100 ml shake cultures in horizont. shaking water bath at 30 deg C; resting cells prepared; lipid extraction and transesterification of trans/cis fatty acids; GC analysis

Further Details (Ecotoxi- isomerization of cis to trans unsat. fatty acids tested as indicator for toxicity of title comp. cology) Results

conc. which caused increase in trans/cis ratio of unsatur. fatty acids to 50 percent of max. trans/cis level reached at satur. conc. of toxin: 1700.0 mM

Heipieper, Hermann J.; Loffeld, Burkhard; Keweloh, Heribert; Bont, Jan A. M. de; Chemosphere; vol. 30; nb. 6; (1995); p. 1041 - 1052, View in Reaxys 121 of 142 Effect (Ecotoxicology)

toxicity to aquatic invertebrates

Species or Test-System (Ecotoxicology)

Mytilus edulis, blue mussel

Concentration (Ecotoxicology)

5000 mg/l

35/42

2016-05-10 05:50:17

Kind of Dosing (Ecotoxi- test chem. added from stock solutions at a constant rate; 96 h exposure to test chem. with cology) a subsequent 96 h recovery period in unpolluted seawater Exposure Period (Ecotoxicology)

192 h

Method (Ecotoxicology)

mussels obtained from a mussel farm on the coast of Troendelag, Norway; shell length 40-50 mm; kept in continuous flow of sea water; not fed; expos. carried out in flow-through exposure system; each individ. in separate chamber;10 deg C; constant light

Further Details (Ecotoxi- sodium gradient across cell membranes (posterior adductor muscle) cology) Comment (Ecotoxicology)

No effect

Borseth, Jan Fredrik; Aunaas, Tore; Denstad, John-Peder; Nordtug, Trond; Olsen, Anders Johny; Schmid, Rudolf; Skjaervo, Gine; Zachariassen, Karl Erik; Aquatic Toxicology; vol. 31; nb. 3; (1995); p. 263 - 276, View in Reaxys 122 of 142 Effect (Ecotoxicology)

enzyme; examination of

Species or Test-System (Ecotoxicology)

free urease

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

free urease toxicity assay; T: 35 deg C; 96-well microplate; absorbance at 575 nm measured; urease from Jack beans (Sigma, EC 3.5.1.5)

Type (Ecotoxicology)

IC50

Value of Type (Ecotoxicology)

> 100000 mg/l

Jung, K.; Bitton, G.; Koopman, B.; Water Research; vol. 29; nb. 8; (1995); p. 1929 - 1933, View in Reaxys 123 of 142 Effect (Ecotoxicology)

enzyme; examination of

Endpoint of Effect (Ecotoxicology)

dichloromethane dehalogenase activity

Species or Test-System (Ecotoxicology)

Hyphomicrobium sp. DM2

Method (Ecotoxicology)

aerobic (O2) and anaerobic (denitrification condition, NO3(-)) growth conditions; enzyme activity based on measuring the rate of formaldehyde formation

Results

specific activity: 0.07, 0.14 mkat/kg protein; specific growth rate μ: 0.08, 0.04 1/h; yield coefficients YP/C: 7.9, 6.2 g protein/mol C (aerobic, denitrification conditions, respectively)

Kohler-Staub; Frank; Leisinger; Biodegradation; vol. 6; nb. 3; (1995); p. 229 - 235, View in Reaxys 124 of 142 Effect (Ecotoxicology)

toxicity to plant cell culture

Species or Test-System (Ecotoxicology)

Nicotiana tabacum L. cv. Bel B, tobacco

Exposure Period (Ecotoxicology)

15 h

Method (Ecotoxicology)

measurements of ion leakage

Further Details (Ecotoxi- 7-d old culture; electrical conductivity-medium; measurements at 120 rpm and 25 deg C; cology) conc.: 1 percent (v/v) Results

no increase in medium conductivity

Koch, U.; Glatzle, D.; Ringenbach, F.; Dunz, T.; Steger-Hartmann, T.; Wagner, E.; Bulletin of Environmental Contamination and Toxicology; vol. 54; nb. 4; (1995); p. 606 - 613, View in Reaxys 125 of 142 Effect (Ecotoxicology)

behavioral symtoms

Species or Test-System (Ecotoxicology)

Chironomus riparius larvae

Concentration (Ecotoxicology)

62 - 1130 mmol/l

36/42

2016-05-10 05:50:17

Exposure Period (Ecotoxicology)

96 - 98 h

Method (Ecotoxicology)

semistatic substrate-water system; water renewed every 24 h; 5 toxicant concentrations; 1-h activity patterns registration by impedance conversion technique

Further Details (Ecotoxi- midges acclimatization for 24 h at 19 deg C in filtered water from Lake Maarsseveen cology) (Utrecht, Netherlands, hardness 150 mg/l as CaCO3, pH 8) at 16-h light/8-h dark regime; ventilation; feeding and tube maintainance activities; inactive behaviour Results

significant increase in ventilation at relatively high concns.; exposure conc. after 0 h and 24 h

Zandt, Peter T. J. van der; Heinis, Floor; Kikkert, Arjen; Aquatic Toxicology; vol. 28; nb. 3,4; (1994); p. 209 - 222, View in Reaxys 126 of 142 Species or Test-System (Ecotoxicology)

Chironomus riparius larvae

Exposure Period (Ecotoxicology)

96 - 98 h

Method (Ecotoxicology)

semistatic substrate-water system; 5 toxicant concentrations; 1-h activity patterns registration by impedance conversion technique

Further Details (Ecotoxi- midges: laboratory culture established 5 years ago; acclimatized for 24 h at 19 deg C in cology) filtered water from Lake Maarsseveen (Utrecht, Netherlands, hardness 150 mg/l as CaCO3, pH 8) at 16-h light/8-h dark regime Type (Ecotoxicology)

NO(A)EC

Value of Type (Ecotoxicology)

320 mmol/l

Zandt, Peter T. J. van der; Heinis, Floor; Kikkert, Arjen; Aquatic Toxicology; vol. 28; nb. 3,4; (1994); p. 209 - 222, View in Reaxys 127 of 142 Effect (Ecotoxicology)

toxicity to aquatic invertebrates (acute)

Endpoint of Effect (Ecotoxicology)

immobility

Species or Test-System (Ecotoxicology)

Daphnia magna

Exposure Period (Ecotoxicology)

24 h

Method (Ecotoxicology)

acute toxicity test according to OECD standard protocol (1980); visual determination of immobility

Further Details (Ecotoxi- Standard Reference Water: NaHCO3 2.4 mM, K2SO4 0.15 mM, CaCl2 2.0 mM, KH2PO4 cology) 0.01 mM, pH 7.6; 21 deg C; >24 h old neonates; no feeding and no aeration Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

649.3 mmol/l

Lilius, Henrik; Isomaa, Boris; Holmstroem, Tim; Aquatic Toxicology; vol. 30; nb. 1; (1994); p. 47 - 60, View in Reaxys 128 of 142 Effect (Ecotoxicology)

toxicity to fish (acute)

Endpoint of Effect (Ecotoxicology)

(86)Rb-leakage

Species or Test-System (Ecotoxicology)

Oncorhynchus mykiss, rainbow trout; hepatocyte

Exposure Period (Ecotoxicology)

Method (Ecotoxicology)

cells incubation with (86)Rb(1+); cells incubation with test chemical; determination of supernatant radioactivity

Further Details (Ecotoxi- hepatocytes isolation by two-step collagenase perfusion; incubation buffer: 68 mM NaCl, cology) 5.4 mM KCl, 1.2 mM CaCl2, 0.6 mM MgCl2, 1.1 mM KH2PO4, 0.7 mM Na2SO4, 30 mM

37/42

2016-05-10 05:50:17

HEPES, 30 mM TES, 36 mM Tricine, pH 7.6, 1 percent BSA and 10 mM glucose; 2E6 cells per ml Type (Ecotoxicology)

EC50

Value of Type (Ecotoxicology)

5364 mmol/l

Lilius, Henrik; Isomaa, Boris; Holmstroem, Tim; Aquatic Toxicology; vol. 30; nb. 1; (1994); p. 47 - 60, View in Reaxys 129 of 142 Effect (Ecotoxicology)

toxicity

Endpoint of Effect (Ecotoxicology)

immobilization

Species or Test-System (Ecotoxicology)

Tetrahymena pyriformis, ciliate

Exposure Period (Ecotoxicology)

30 s

Method (Ecotoxicology)

Motility Assay; cells exposure to test chemical; cell-tracking parameters automated monitoring

Further Details (Ecotoxi- ciliate from American Tissue Type Collection, MD, USA; cell density between 1E2 and cology) 1E4 cells/mL; yeast media Type (Ecotoxicology)

average tolerated dose

Value of Type (Ecotoxicology)

39900 dilution factor

Results

average tolerated dose as the reciprocal sum of the high (90 percent motile) and low (10 percent motile) dose

Noever; Matsos; Cronise; Looger; Relwani; Johnson; Chemosphere; vol. 29; nb. 6; (1994); p. 1373 - 1384, View in Reaxys 130 of 142 Effect (Ecotoxicology)

toxicity to aquatic invertebrates (acute)

Species or Test-System (Ecotoxicology)

Brachionus calyciflorus

Exposure Period (Ecotoxicology)

24 h

Method (Ecotoxicology)

LC50s of test comp. determined by Standard Operational Procedures for Rotoxkit F test; principial component analysis (PCA) and cluster analysis used for evaluation of all toxicity data

Further Details (Ecotoxi- test comp. belongs to chemicals of Multicentre Evaluation of In Vitro Cytotoxicity (MEIC) cology) programme Type (Ecotoxicology)

LC50

Value of Type (Ecotoxicology)

1120000 μmol/l

Results

comparison with data of further tests: Artoxkit M, Streptoxkit F, test with Daphnia magna and Microtox test

Calleja; Persoone; Geladi; Archives of Environmental Contamination and Toxicology; vol. 26; nb. 1; (1994); p. 69 78, View in Reaxys 131 of 142 Effect (Ecotoxicology)

toxicity to aquatic invertebrates (acute)

Species or Test-System (Ecotoxicology)

Daphnia magna

Exposure Period (Ecotoxicology)

24 h

Method (Ecotoxicology)

immobility test performed according to OECD guidelines (OECD 1984); principial component analysis (PCA) and cluster analysis used for evaluation of all toxicity data

Further Details (Ecotoxi- test comp. belongs to chemicals of Multicentre Evaluation of In Vitro Cytotoxicity (MEIC) cology) programme Type (Ecotoxicology)

EC50

38/42

2016-05-10 05:50:17

Value of Type (Ecotoxicology)

668000 μmol/l

Results

comparison with data of further tests: Artoxkit M, Rotoxkit F, Streptoxkit F and Microtox test

Calleja; Persoone; Geladi; Archives of Environmental Contamination and Toxicology; vol. 26; nb. 1; (1994); p. 69 78, View in Reaxys 132 of 142 Effect (Ecotoxicology)

toxicity to aquatic invertebrates (acute)

Species or Test-System (Ecotoxicology)

Streptocephalus proboscideus

Exposure Period (Ecotoxicology)

24 h

Method (Ecotoxicology)

LC50s of test comp. determined by Standard Operational Procedures for Streptoxkit F test; principial component analysis (PCA) and cluster analysis used for evaluation of all toxicity data

Further Details (Ecotoxi- test comp. belongs to chemicals of Multicentre Evaluation of In Vitro Cytotoxicity (MEIC) cology) programme Type (Ecotoxicology)

LC50

Value of Type (Ecotoxicology)

1020000 μmol/l

Results

comparison with data of further tests: Artoxkit M, Rotoxkit F, test with Daphnia magna and Microtox test

Calleja; Persoone; Geladi; Archives of Environmental Contamination and Toxicology; vol. 26; nb. 1; (1994); p. 69 78, View in Reaxys 133 of 142 Effect (Ecotoxicology)

toxicity to aquatic invertebrates (acute)

Species or Test-System (Ecotoxicology)

Artemia salina

Exposure Period (Ecotoxicology)

24 h

Method (Ecotoxicology)

LC50s of test comp. determined by Standard Operational Procedures for Artoxkit M test; principial component analysis (PCA) and cluster analysis used for evaluation of all toxicity data

Further Details (Ecotoxi- test comp. belongs to chemicals of Multicentre Evaluation of In Vitro Cytotoxicity (MEIC) cology) programme Type (Ecotoxicology)

LC50

Value of Type (Ecotoxicology)

1360000 μmol/l

Results

comparison with data of further tests: Streptoxkit F, Rotoxkit F, test with Daphnia magna and Microtox test

Calleja; Persoone; Geladi; Archives of Environmental Contamination and Toxicology; vol. 26; nb. 1; (1994); p. 69 78, View in Reaxys 134 of 142 Effect (Ecotoxicology)

toxicity to bacteria

Species or Test-System (Ecotoxicology)

Photobacterium phosphoreum

Exposure Period (Ecotoxicology)

5 - 15 min

Method (Ecotoxicology)

Microtox test performed according to Microbics 1989; 15-min exposure used when stable and repeatable EC50s could not be calculated after 5-min exposure; principial component analysis (PCA) and cluster analysis used for evaluation of all toxicity data

Further Details (Ecotoxi- test comp. belongs to chemicals of Multicentre Evaluation of In Vitro Cytotoxicity (MEIC) cology) programme Type (Ecotoxicology)

EC50

39/42

2016-05-10 05:50:17

Value of Type (Ecotoxicology)

916000 μmol/l

Results

comparison with data of further tests: Artoxkit M, Streptoxkit F, Rotoxkit F and test with Daphnia magna

Calleja; Persoone; Geladi; Archives of Environmental Contamination and Toxicology; vol. 26; nb. 1; (1994); p. 69 78, View in Reaxys 135 of 142 Effect (Ecotoxicology)

cytotoxicity

Species or Test-System (Ecotoxicology)

Nicotiana sylvestris Speg. and Comes cv. SCR

Exposure Period (Ecotoxicology)

18 h

Method (Ecotoxicology)

pollen tube growth (PTG) assay; pollen of tobacco plants were collected during early stages of anthesis, suspended; incubated with increasing concentration of chemical at 27 deg C

Type (Ecotoxicology)

IC50

Value of Type (Ecotoxicology)

35.7 g/l

Barile; Dierickx; Kristen; Cell Biology and Toxicology; vol. 10; nb. 3; (1994); p. 155 - 162, View in Reaxys 136 of 142 Effect (Ecotoxicology)

microorganisms

Species or Test-System (Ecotoxicology)

Hyphomicrobium strain VS

Concentration (Ecotoxicology)

10 mmol/l

Method (Ecotoxicology)

respiration rates measured polarographically; growth measuring

Further Details (Ecotoxi- bacterium enrichment: 1) activated sewage sludge, 2) mineral salts medium (pH 6 to 8, cology) temp. 30 deg C); enzyme assay Results

growth activation

Pol; Op den Camp; Mees; Kersten; van der Drift; Biodegradation; vol. 5; nb. 2; (1994); p. 105 - 112, View in Reaxys 137 of 142 Effect (Ecotoxicology)

luminescence; inhibition of

Species or Test-System (Ecotoxicology)

Photobacterium phosphoreum

Exposure Period (Ecotoxicology)

5 min

Method (Ecotoxicology)

Photobacterium phosphoreum (Microtox) test

Further Details (Ecotoxi- human acute toxicity prediction by a battery of ecotoxicological tests and physicochemical cology) properties; best partial least squares (PLS) model; Multicentre Evaluation of In Vitro Cytotoxicity programme Results

mean logarithm of acute toxicity <L(E)C50>: 5.96

Calleja; Persoone; Geladi; Food and Chemical Toxicology; vol. 32; nb. 2; (1994); p. 173 - 187, View in Reaxys 138 of 142 Effect (Ecotoxicology)

toxicity to aquatic invertebrates (acute)

Endpoint of Effect (Ecotoxicology)

acute toxicity

Species or Test-System (Ecotoxicology)

Brachionus calyciflorus

Exposure Period (Ecotoxicology)

24 h

Method (Ecotoxicology)

Brachionus calyciflorus (Rotoxkit F) test

40/42

2016-05-10 05:50:17

Results

mean logarithm of acute toxicity <L(E)C50>: 6.05

Calleja; Persoone; Geladi; Food and Chemical Toxicology; vol. 32; nb. 2; (1994); p. 173 - 187, View in Reaxys 139 of 142 Effect (Ecotoxicology)

toxicity to aquatic invertebrates (acute)

Endpoint of Effect (Ecotoxicology)

acute toxicity

Species or Test-System (Ecotoxicology)

Daphnia magna

Exposure Period (Ecotoxicology)

24 h

Method (Ecotoxicology)

Daphnia magna test; OECD, 1984

mean logarithm acute toxicity <log L(E)C50>: 5.82

Calleja; Persoone; Geladi; Food and Chemical Toxicology; vol. 32; nb. 2; (1994); p. 173 - 187, View in Reaxys 140 of 142 Effect (Ecotoxicology)

toxicity to aquatic invertebrates (acute)

Endpoint of Effect (Ecotoxicology)

acute toxicity

Species or Test-System (Ecotoxicology)

Streptocephalus proboscideus

Exposure Period (Ecotoxicology)

24 h

Method (Ecotoxicology)

Streptocephalus proboscideus (Streptoxkit F) test

mean logarithm acute toxicity <log L(E)C50>: 6.01

Calleja; Persoone; Geladi; Food and Chemical Toxicology; vol. 32; nb. 2; (1994); p. 173 - 187, View in Reaxys 141 of 142 Effect (Ecotoxicology)

toxicity to aquatic invertebrates (acute)

Endpoint of Effect (Ecotoxicology)

acute toxicity

Species or Test-System (Ecotoxicology)

Artemia salina

Exposure Period (Ecotoxicology)

24 h

Method (Ecotoxicology)

Artemia salina (Artoxkit M) test

mean logarithm acute toxicity <log L(E)C50>: 6.13

Calleja; Persoone; Geladi; Food and Chemical Toxicology; vol. 32; nb. 2; (1994); p. 173 - 187, View in Reaxys 142 of 142 Effect (Ecotoxicology)

toxicity to aquatic invertebrates (acute)

Endpoint of Effect (Ecotoxicology)

mortality

Species or Test-System (Ecotoxicology)

Artemia salina

Exposure Period (Ecotoxicology)

24 h

Further Details (Ecotoxi- 10 nauplius larvae for each experiment; treated at 25 deg C in the dark; 10 sec observacology) tion; 24-, 48- and 72-hr old larvae

41/42

2016-05-10 05:50:17

Type (Ecotoxicology)

LC50

Value of Type (Ecotoxicology)

900.73 - 1578.84 mg/l

Results

results with 95 percent CL

Barahona-Gomariz, M. V.; Sanz-Barrera, F.; Sanchez-Fortun, S.; Bulletin of Environmental Contamination and Toxicology; vol. 52; nb. 5; (1994); p. 766 - 771, View in Reaxys

42/42

2016-05-10 05:50:17