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Date
6 reactions in Reaxys
2016-06-15 14h:28m:46s (EST)
O
1. Query
N
Search as: As drawn
Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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OH
H N
O
N
Rx-ID: 39395162 View in Reaxys 1/6 Yield
Conditions & References
66 %
Stage 1: With N-bromosuccinmide in 1,4-dioxane Stage 2: in 1,4-dioxane, Time= 24h, T= 20 °C Guha, Somraj; Rajeshkumar, Venkatachalam; Kotha, Surya Srinivas; Sekar, Govindasamy; Organic Letters; vol. 17; nb. 3; (2015); p. 406 - 409 View in Reaxys
O
O
N
Rx-ID: 39395141 View in Reaxys 2/6 Yield
Conditions & References Reaction Steps: 2 1.1: magnesium; iodine / tetrahydrofuran / 0.5 h / |Inert atmosphere 1.2: 0 °C / |Inert atmosphere 2.1: N-bromosuccinmide / 1,4-dioxane 2.2: 24 h / 20 °C With N-bromosuccinmide, iodine, magnesium in tetrahydrofuran, 1,4-dioxane, 1.1: |Grignard Reaction Guha, Somraj; Rajeshkumar, Venkatachalam; Kotha, Surya Srinivas; Sekar, Govindasamy; Organic Letters; vol. 17; nb. 3; (2015); p. 406 - 409 View in Reaxys
O Br
N
Rx-ID: 39395178 View in Reaxys 3/6 Yield
Conditions & References Reaction Steps: 2 1.1: magnesium; iodine / tetrahydrofuran / 0.5 h / |Inert atmosphere 1.2: 0 °C / |Inert atmosphere 2.1: N-bromosuccinmide / 1,4-dioxane 2.2: 24 h / 20 °C With N-bromosuccinmide, iodine, magnesium in tetrahydrofuran, 1,4-dioxane, 1.1: |Grignard Reaction Guha, Somraj; Rajeshkumar, Venkatachalam; Kotha, Surya Srinivas; Sekar, Govindasamy; Organic Letters; vol. 17; nb. 3; (2015); p. 406 - 409 View in Reaxys
O
O
N
Rx-ID: 12456453 View in Reaxys 4/6
Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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Yield
Conditions & References Reaction Steps: 2 1: AlCl3; bromine 2: diethyl ether / 22 °C With aluminium trichloride, bromine in diethyl ether Meltzer, Peter C.; Butler, David; Deschamps, Jeffrey R.; Madras, Bertha K.; Journal of Medicinal Chemistry; vol. 49; nb. 4; (2006); p. 1420 - 1432 View in Reaxys
O
H N
O Br
N
Rx-ID: 10159278 View in Reaxys 5/6 Yield
Conditions & References in diethyl ether, T= 22 °C Meltzer, Peter C.; Butler, David; Deschamps, Jeffrey R.; Madras, Bertha K.; Journal of Medicinal Chemistry; vol. 49; nb. 4; (2006); p. 1420 - 1432 View in Reaxys
O Cl
H
N
Rx-ID: 28001388 View in Reaxys 6/6 Yield 50 %
Conditions & References 35 Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; ORGANIX, INC.; WO2005/34878; (2005); (A2) English View in Reaxys
Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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