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3 reactions in Reaxys
2016-06-11 19h:42m:41s (EST)
Cl
1. Query NH
Search as: As drawn
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2016-06-11 19:52:48
HN
Cl NH HN
S O
O
N Z
O
NH O S HN
Cl
Cl
Rx-ID: 25189646 View in Reaxys 1/3 Yield
Conditions & References 23.a : (a) (a) 3-(2-Chloroethyl)-N-methyl-1H-indole-5-methanesulphonamide A solution of the product of example 6(a) (0.25 g) in chloroform (3 ml) was added to a solution of polyphosphate ester (2.5 g) in chloroform (2 ml) and the solution was heated under reflux with stirring for 5 min. The solution became dark yellow. It was then cooled and poured onto ice (20 g) and chloroform (5 ml) and stirred. The aqueous phase was brought to pH 8 by the addition of sodium bicarbonate and the organic layer was collected. The aqueous layer was extracted with chloroform (4*20 ml) and the extracts dried (Na2 SO4). Removal of the solvent in vacuo gave the crude 3-chloroethyl indole as a light brown viscous oil (0.677 g) which was used in the next experiment without further purification. With polyphosphate ester in chloroform Patent; Glaxo Group Limited; US4816470; (1989); (A1) English View in Reaxys
NH
2-(3-indolyl)ethylbis(dimethylglyoximato)pyridinecobalt(III) Cl
Rx-ID: 5671830 View in Reaxys 2/3 Yield
Conditions & References With trichloroacetonitrile in dichloromethane, Time= 2h, T= 50 - 60 °C , in a sealed tube Ashcroft, Martyn R.; Bougeard, Peter; Bury, Adrian; Cooksey, Christopher J.; Johnson, Michael D.; Journal of Organometallic Chemistry; vol. 289; (1985); p. 403 - 416 View in Reaxys
NH
NH
OH
Cl
Rx-ID: 113011 View in Reaxys 3/3 Yield
Conditions & References With pyridine, thionyl chloride Kotake et al.; ; vol. 1; nb. 1; (1950); p. 7,9 View in Reaxys
Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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2016-06-11 19:52:48