Query Query
Results
Date
9 substances in Reaxys
2016-06-08 10h:29m:55s (EST)
H N
1. Query
NH 2
Search as: As drawn
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2016-06-08 10:32:18
Reaxys ID 742937 View in Reaxys
1/9
H N
CAS Registry Number: 55-52-7 Chemical Name: pheniprazine; Pheniprazine; (1-methyl-2-phenylethyl)hydrazine; (1-methyl-2-phenyl-ethyl)-hydrazine; (+-)-(1methyl-2-phenyl-ethyl)-hydrazine; (+-)-(1-Methyl-2-phenyl-aethyl)-hydrazin; (1-methyl-2-phenyl-ethyl)hydrazine Linear Structure Formula: C9H14N2 Molecular Formula: C9H14N2 Molecular Weight: 150.224 Type of Substance: isocyclic InChI Key: VXTWEDPZMSVFEF-UHFFFAOYSA-N Note:
NH 2
Substance Label (7) Label References 10;R1=Me,R2=H, E=CH2Ph
Baldwin, Jack E.; Adlington, Robert M.; Newington, Ian M.; Journal of the Chemical Society, Chemical Communications; nb. 2; (1986); p. 176 - 178, View in Reaxys
V
Kauffmann,T. et al.; Chemische Berichte; vol. 98; (1965); p. 904 - 911, View in Reaxys
Tab.II
Anderson,F.E. et al.; Journal of Medicinal and Pharmaceutical Chemistry; vol. 5; nb. 2; (1962); p. 221 - 230, View in Reaxys
5
Patent; Lakeside Labor.; US3000903; (1959); Chem.Abstr.; vol. 56; nb. 1393; (1962), View in Reaxys
6
Patent; Hoffmann-LaRoche; DE1132142; (1959); GB867985; Chem.Abstr.; nb. 25722; (1961), View in Reaxys; Patent; Lakeside Labor.; US3000903; (1959); Chem.Abstr.; vol. 56; nb. 1393; (1962), View in Reaxys
3
Patent; Hoffmann-LaRoche; DE1132142; (1959); GB867985; Chem.Abstr.; nb. 25722; (1961), View in Reaxys
1
Patent; Lakeside Labor.; US2978461; (1958); Chem.Abstr.; nb. 25861; (1961), View in Reaxys
Derivative (6) Comment (Derivative)
References
*HCl:F: 122-123grad
Franguesa-Graner; Galenica Acta; vol. 14; nb. 2; (1961); p. 81,82-89; Chem.Abstr.; nb. 27166; (1961), View in Reaxys
*HCl:Coulometr.Bestimmung
Olson; Analytical Chemistry; vol. 32; (1960); p. 1545, View in Reaxys
*HCl: 115-116grad(aus Propan-2-ol + Diethylether)
Patent; Lakeside Labor.; US3000903; (1959); Chem.Abstr.; vol. 56; nb. 1393; (1962), View in Reaxys
HCl-Salz: F: 115-116grad
Patent; Colgate; US3359316; (1958); Chem.Abstr.; vol. 69; nb. 10210g; (1968), View in Reaxys
*HCl:aus den Komponenten in Isopropylalkohol +Diisopropylether(1:10);F: 124-125grad(aus Acetonitril)
Patent; Lakeside Labor.; US2978461; (1958); Chem.Abstr.; nb. 25861; (1961), View in Reaxys
Hydrochlorid: F: 115-116grad
Patent; Lakeside Labs., Inc.; GB863158; (1957); US; (1956); Chem.Abstr.; vol. 56; nb. 14168f; (1962), View in Reaxys; Patent; Colgate-Palmolive; US3334017; (1956); Chem.Abstr.; vol. 68; nb. 12676s; (1968), View in Reaxys
Boiling Point (8) Boiling Point [°C]
Pressure (Boiling Point) [Torr]
References
80 - 82
0.1
Kauffmann,T. et al.; Chemische Berichte; vol. 98; (1965); p. 904 - 911, View in Reaxys
126 - 130
12
Iffland et al.; Journal of the American Chemical Society; vol. 83; (1961); p. 747,748, View in Reaxys
135 - 138
10
Patent; Chugai Pharm.; JP13972; (1960); Chem.Abstr.; vol. 59; nb. 9802f; (1963), View in Reaxys
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70
0.02
Patent; Lakeside Labor.; US3000903; (1959); Chem.Abstr.; vol. 56; nb. 1393; (1962), View in Reaxys; Patent; Lakeside Labs., Inc.; GB863158; (1957); US; (1956); Chem.Abstr.; vol. 56; nb. 14168f; (1962), View in Reaxys; Patent; Colgate-Palmolive; US3334017; (1956); Chem.Abstr.; vol. 68; nb. 12676s; (1968), View in Reaxys; Patent; Colgate; US3359316; (1958); Chem.Abstr.; vol. 69; nb. 10210g; (1968), View in Reaxys
82 - 84
0.6
Biel et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 2805,2810, 2813, View in Reaxys
75
0.3
Biel et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 2805,2810, 2813, View in Reaxys
80
0.3
Biel et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 2805,2810, 2813, View in Reaxys
85
0.3
Patent; Lakeside Labor.; US2978461; (1958); Chem.Abstr.; nb. 25861; (1961), View in Reaxys
Refractive Index (5) Refractive Index Wavelength (Refractive Index) [nm]
Temperature (Refractive Index) [°C]
References
1.5395
589
20
Iffland et al.; Journal of the American Chemical Society; vol. 83; (1961); p. 747,748, View in Reaxys
1.5373
589
20
Patent; Lakeside Labor.; US3000903; (1959); Chem.Abstr.; vol. 56; nb. 1393; (1962), View in Reaxys; Patent; Lakeside Labs., Inc.; GB863158; (1957); US; (1956); Chem.Abstr.; vol. 56; nb. 14168f; (1962), View in Reaxys; Patent; Colgate-Palmolive; US3334017; (1956); Chem.Abstr.; vol. 68; nb. 12676s; (1968), View in Reaxys
1.5338 - 1.5375
589
20
Biel et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 2805,2810, 2813, View in Reaxys
1.5373
589
25
Patent; Colgate; US3359316; (1958); Chem.Abstr.; vol. 69; nb. 10210g; (1968), View in Reaxys
1.5375
589
20
Patent; Lakeside Labor.; US2978461; (1958); Chem.Abstr.; nb. 25861; (1961), View in Reaxys
Density (1) 1 of 1
Density [g·cm-3]
0.995
Reference Temperature [°C]
4
Measurement Temperature [°C]
20
Iffland et al.; Journal of the American Chemical Society; vol. 83; (1961); p. 747,748, View in Reaxys Crystal Property Description (1) Colour & Other Location Properties yellow
supporting information
References Radi, Marco; Dreassi, Elena; Brullo, Chiara; Crespan, Emmanuele; Tintori, Cristina; Bernardo, Vincenzo; Valoti, Massimo; Zamperini, Claudio; Daigl, Henry; Musumeci, Francesca; Carraro, Fabio; Naldini, Antonella; Filippi, Irene; Maga, Giovanni; Schenone, Silvia; Botta, Maurizio; Journal of Medicinal Chemistry; vol. 54; nb. 8; (2011); p. 2610 - 2626, View in Reaxys
Dissociation Exponent (1) 1 of 1
Comment (Dissociation Exponent)
(pk')pKa':7,14 (titrimetr.Best.)
Eberson; Persson; Journal of Medicinal and Pharmaceutical Chemistry; vol. 5; (1962); p. 738,746, View in Reaxys Further Information (3) Description (Fur- References ther Information) Further information
Olson; Analytical Chemistry; vol. 32; (1960); p. 1545, View in Reaxys
Further information
Patent; Lakeside Labor.; US3000903; (1959); Chem.Abstr.; vol. 56; nb. 1393; (1962), View in Reaxys
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Further information
Patent; Lakeside Labor.; US2978461; (1958); Chem.Abstr.; nb. 25861; (1961), View in Reaxys
Pharmacological Data (2) 1 of 2
Comment (Pharmacological Data)
Bioactivities present
Kauffmann,T. et al.; Chemische Berichte; vol. 98; (1965); p. 904 - 911, View in Reaxys; Drain,D.J. et al.; J. Med. Chem.; vol. 6; (1963); p. 63 - 69, View in Reaxys; Rooney,C.S. et al.; Journal of Medicinal and Pharmaceutical Chemistry; vol. 5; (1962); p. 155 - 167, View in Reaxys; Anderson,F.E. et al.; Journal of Medicinal and Pharmaceutical Chemistry; vol. 5; nb. 2; (1962); p. 221 - 230, View in Reaxys; Gardner,T.S. et al.; Journal of Medicinal and Pharmaceutical Chemistry; vol. 5; (1962); p. 503 - 513, View in Reaxys; Bracci Torsi,C.; Vuat,M.; Gazzetta Chimica Italiana; vol. 91; (1961); p. 1461 - 1474, View in Reaxys; Yashunskii,V.G.; Vasil'eva,V.G.; J. Gen. Chem. USSR (Engl. Transl.); vol. 30; (1960); p. 2754 - 2756,2736 - 2738, View in Reaxys; Patent; SHELDON, Leslie James; WO2005/53703; (2005); (A1) English, View in Reaxys; Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys; Biel et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 2805,2810, 2813, View in Reaxys; Eberson; Persson; Journal of Medicinal and Pharmaceutical Chemistry; vol. 5; (1962); p. 738,746, View in Reaxys; Patent; Hoffmann-LaRoche; DE1132142; (1959); GB867985; Chem.Abstr.; nb. 25722; (1961), View in Reaxys; Kauffmann et al.; Chemische Berichte; vol. 99; (1966); p. 3148, View in Reaxys; Patent; Lakeside Labor.; US3000903; (1959); Chem.Abstr.; vol. 56; nb. 1393; (1962), View in Reaxys; Franguesa-Graner; Galenica Acta; vol. 14; nb. 2; (1961); p. 81,82-89; Chem.Abstr.; nb. 27166; (1961), View in Reaxys; Olson; Analytical Chemistry; vol. 32; (1960); p. 1545, View in Reaxys; Patent; Lakeside Labor.; US2978461; (1958); Chem.Abstr.; nb. 25861; (1961), View in Reaxys; Patent; Chugai Pharm.; JP13972; (1960); Chem.Abstr.; vol. 59; nb. 9802f; (1963), View in Reaxys; Iffland et al.; Journal of the American Chemical Society; vol. 83; (1961); p. 747,748, View in Reaxys; Patent; Lakeside Labs., Inc.; GB863158; (1957); US; (1956); Chem.Abstr.; vol. 56; nb. 14168f; (1962), View in Reaxys; Lindstroem et al.; European Journal of Biochemistry; vol. 42; (1974); p. 177,180, View in Reaxys; Patent; Colgate-Palmolive; US3334017; (1956); Chem.Abstr.; vol. 68; nb. 12676s; (1968), View in Reaxys; Patent; Colgate; US3359316; (1958); Chem.Abstr.; vol. 69; nb. 10210g; (1968), View in Reaxys; Kauffmann et al.; Chemische Berichte; vol. 98; (1965); p. 912,914,920, View in Reaxys; Riley; Brier; Journal of medicinal chemistry; vol. 15; nb. 11; (1972); p. 1187 - 1188, View in Reaxys; Wolff, Hans Peter; Kuehnle, Hans F.; Journal of Medicinal Chemistry; vol. 28; nb. 10; (1985); p. 1436 - 1440, View in Reaxys; Baldwin, Jack E.; Adlington, Robert M.; Newington, Ian M.; Journal of the Chemical Society, Chemical Communications; nb. 2; (1986); p. 176 - 178, View in Reaxys; Kane, John M.; Dudley, Mark W.; Sorensen, Stephen M.; Miller, Francis P.; Journal of Medicinal Chemistry; vol. 31; nb. 6; (1988); p. 1253 - 1258, View in Reaxys; Radi, Marco; Dreassi, Elena; Brullo, Chiara; Crespan, Emmanuele; Tintori, Cristina; Bernardo, Vincenzo; Valoti, Massimo; Zamperini, Claudio; Daigl, Henry; Musumeci, Francesca; Carraro, Fabio; Naldini, Antonella; Filippi, Irene; Maga, Giovanni; Schenone, Silvia; Botta, Maurizio; Journal of Medicinal Chemistry; vol. 54; nb. 8; (2011); p. 2610 - 2626, View in Reaxys; Ramadan, Zakia Ben; Wrang, Maria L.; Tipton, Keith F.; Neurochemical Research; vol. 32; nb. 10; (2007); p. 1783 - 1790, View in Reaxys; Patent; UNIVERSITA' DEGLI STUDI DI PADOVA, (UNIVERSITY OF PADUA); US2012/329800; (2012); (A1) English, View in Reaxys; Burger; Nara; Journal of medicinal chemistry; vol. 8; nb. 6; (1965); p. 859 - 862, View in Reaxys; Creveling; Daly; Witkop; Journal of medicinal chemistry; vol. 9; nb. 3; (1966); p. 284 - 286, View in Reaxys; Valzelli; Giacalone; Garattini; European journal of pharmacology; vol. 2; nb. 2; (1967); p. 144 - 146, View in Reaxys; Mills; Kattau; Slater; Fuller; Journal of medicinal chemistry; vol. 11; nb. 1; (1968); p. 95 - 97, View in Reaxys; Hsu; Huang; Waters; Journal of Medicinal Chemistry; vol. 18; nb. 1; (1975); p. 20 - 23, View in Reaxys; Florvall; Ask; Ogren; Ross; Journal of medicinal chemistry; vol. 21; nb. 1; (1978); p. 56 - 63, View in Reaxys; Ziance; Moxley; Mullis; Gray; Archives Internationales de Pharmacodynamie et de Therapie; vol. 228; nb. 1; (1977); p. 30 - 38, View in Reaxys; Colpaert; Niemegeers; Janssen; Pharmacology Biochemistry and Behavior; vol. 13; nb. 4; (1980); p. 513 - 517, View in Reaxys; Kane; Dudley; Sorensen; Miller; Journal of Medicinal Chemistry; vol. 31; nb. 6; (1988); p. 1253 - 1258, View in Reaxys; Fujita; Journal of Medicinal Chemistry; vol. 16; nb. 8; (1973); p. 923 - 930, View in Reaxys; Lahti; Platz; McAllister; Journal of medicinal chemistry; vol. 13; nb. 4; (1970); p. 681 - 683, View in Reaxys; JACOB FINKELSTEIN; JOHN A.ROMANO; ELLIOT CHIANG; JOHN LEE; Journal of medicinal chemistry; vol. 6; nb. 2; (1963); p. 153 - 155, View in Reaxys; DONALD L. 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2 of 2
Comment (Pharmacological Data)
antidepressant activity, LD 50, mg/kg = 100-200, antagonism of RO 4-1284-induced hypothermia, ED 50, mg/kg, = 1.10, antagonism of reserpine-induced ptosis, Ed 50, mg/kg, = 1.61 (mice)
Kane, John M.; Dudley, Mark W.; Sorensen, Stephen M.; Miller, Francis P.; Journal of Medicinal Chemistry; vol. 31; nb. 6; (1988); p. 1253 - 1258, View in Reaxys Use (126) Use Pattern
Location
References
inhibiting the production of reactive oxygen species in a muscle cell overproducing reactive oxygen species
Page/Page column title page; 13-17
Patent; UNIVERSITA' DEGLI STUDI DI PADOVA, (UNIVERSITY OF PADUA); US2012/329800; (2012); (A1) English, View in Reaxys
monoamine oxidase inhibitor
Page/Page column title page; 13-17
Patent; UNIVERSITA' DEGLI STUDI DI PADOVA, (UNIVERSITY OF PADUA); US2012/329800; (2012); (A1) English, View in Reaxys
muscle dystrophy (MD)
Page/Page column title page; 13-17
Patent; UNIVERSITA' DEGLI STUDI DI PADOVA, (UNIVERSITY OF PADUA); US2012/329800; (2012); (A1) English, View in Reaxys
Cardiovascular disorder
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Coronary artery disease
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Congestive heart failure
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Angina
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Atherosclerosis
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Hyperlipidemia
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Diabetes
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Neurodegenerative disorder
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
chronic heart failure
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
myocardial infarction
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
cardiogenic shock
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
systemic hypertension
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
pulmonary hypertension
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
ischemia- reperfusion injury
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
coronary vasospastic disorders
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
systemic vasospastic disorders
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
cerebral vasospasm
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
subarachnoid hemorrhage
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
hyperglycemia
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
metabolic disorders
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
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renal disorders
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
neurodegenerative disorders
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Hypertension
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Cardiovascular associated disorder
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
ischemia-reperfusion injury
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
ischaemic heart disease
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
stroke
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
transient ischaemic attack
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
aneurysm
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
angina pectoris
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
angioneurotic edema
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
aortic valve stenosis
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
arrhythmia
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
arrhvthmogenic right ventricular dysplasia
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
arteriosclerosis
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
arteriovenous malformations
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
atrial fibrillation
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Behcet syndrome
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
bradycardia
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
cardiac tamponade
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
cardiomegaly
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
cardiomyopathy
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
dilated cardiomyopathy
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
hypertrophic cardiomyopathy
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
restrictive cardiovascular diseases
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
carotid stenosis
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
cerebral hemorrhage
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Churg-Strauss syndrome
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Ebstein's anomaly
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Eisenmenger complex
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
embolism
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
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endocarditis
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
bacterial fibromuscular dysplasia
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
heart block
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
congenital heart diseases
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
heart valve diseases
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
hematoma
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
ubdural HippelLindau disease
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
hyperemia
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
hypertrophy
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
hypoplastic syndrome
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
intermittent claudication
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Klippel-Trenaunay- Weber syndrome
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
lateral medullary syndrome
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
long QT syndrome
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
microvascular angina
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
mitral valve prolapse
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
moyamoya disease
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
mucocutaneous lymph node syndrome
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
myocardial ischemia
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
myocarditis
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
peripheral vascular diseases
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Phlebitis
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
polyarteritis
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
nodosa
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
pulmonary atresia
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Raynaud disease
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Sneddon syndrome
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
superior vena cava syndrome
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
tachycardia
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Takayasu's arteritis
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
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telangiectasia
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
hereditary hemorrhagic
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
temporal arteritis
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
tetralogy of fallot
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
thromboangiitis obliterans
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
thrombosis
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
tricuspid atresia
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
varicose veins
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
vascular diseases
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Vasculitis
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
vasospasm
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
intracranial
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
ventricular fibrillation
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Williams syndrome
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Wolff-ParkinsonWhite syndrome
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Parkinson's disease
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Alzheimer's disease
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Multiple sclerosis
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Neuropathies
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Huntington's disease
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Amyotrophic lateral sclerosis (ALS)
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Metabolic disorder
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
Renal disorder
Patent; PANACEA BIOTEC LTD; WO2007/54975; (2007); (A1) English, View in Reaxys
non-selective MAO inhibitor; inhibit or affect the activity of monoamine oxidase in the brain
Patent; SHELDON, Leslie James; WO2005/53703; (2005); (A1) English, View in Reaxys
psychiatric disorders
Patent; SHELDON, Leslie James; WO2005/53703; (2005); (A1) English, View in Reaxys
neurodegenerative disorder
Patent; SHELDON, Leslie James; WO2005/53703; (2005); (A1) English, View in Reaxys
dementia
Patent; SHELDON, Leslie James; WO2005/53703; (2005); (A1) English, View in Reaxys
cortical dementia
Patent; SHELDON, Leslie James; WO2005/53703; (2005); (A1) English, View in Reaxys
fronto-temporal dementia
Patent; SHELDON, Leslie James; WO2005/53703; (2005); (A1) English, View in Reaxys
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Alzheimer's dementia
Patent; SHELDON, Leslie James; WO2005/53703; (2005); (A1) English, View in Reaxys
lewy body dementia
Patent; SHELDON, Leslie James; WO2005/53703; (2005); (A1) English, View in Reaxys
progressive dementia
Patent; SHELDON, Leslie James; WO2005/53703; (2005); (A1) English, View in Reaxys
vascular dementia
Patent; SHELDON, Leslie James; WO2005/53703; (2005); (A1) English, View in Reaxys
multi-infarct dementia
Patent; SHELDON, Leslie James; WO2005/53703; (2005); (A1) English, View in Reaxys
drug-or alcoholrelated dementia
Patent; SHELDON, Leslie James; WO2005/53703; (2005); (A1) English, View in Reaxys
Parkinson's-related dementia
Patent; SHELDON, Leslie James; WO2005/53703; (2005); (A1) English, View in Reaxys
depressive disorders
Patent; SHELDON, Leslie James; WO2005/53703; (2005); (A1) English, View in Reaxys
unipolar or major depression
Patent; SHELDON, Leslie James; WO2005/53703; (2005); (A1) English, View in Reaxys
dysthymia
Patent; SHELDON, Leslie James; WO2005/53703; (2005); (A1) English, View in Reaxys
bipolar disorder
Patent; SHELDON, Leslie James; WO2005/53703; (2005); (A1) English, View in Reaxys
behavioral disorder
Patent; SHELDON, Leslie James; WO2005/53703; (2005); (A1) English, View in Reaxys
apathy
Patent; SHELDON, Leslie James; WO2005/53703; (2005); (A1) English, View in Reaxys
Reaxys ID 3914576 View in Reaxys
HN H
2/9 CAS Registry Number: 66-05-7 Chemical Name: Pheniprazine hydrochloride; (+-)-(1-methyl-2phenyl-ethyl)-hydrazine; hydrochloride; (+-)-(1-Methyl-2-phenylaethyl)-hydrazin; Hydrochlorid; pheniprazine Linear Structure Formula: C9H14N2*ClH Molecular Formula: C9H14N2*ClH Molecular Weight: 186.684 Type of Substance: isocyclic InChI Key: HXCTUSBYMZQLKB-UHFFFAOYSA-N Note:
NH 2 Cl
H
Substance Label (2) Label References 2j
Zhang, Jinzhu; Yin, Zhiwei; Leonard, Patrick; Wu, Jing; Sioson, Kate; Liu, Che; Lapo, Robert; Zheng, Shengping; Angewandte Chemie - International Edition; vol. 52; nb. 6; (2013); p. 1753 - 1757; Angew. Chem.; vol. 125; nb. 6; (2013); p. 1797 - 1801,5, View in Reaxys
Tab.II
Anderson,F.E. et al.; Journal of Medicinal and Pharmaceutical Chemistry; vol. 5; nb. 2; (1962); p. 221 - 230, View in Reaxys
Patent-Specific Data (1) Location in Patent References Claim
Patent; Tam, Peter; Gesundheit, Neil; Wilson, Leland F.; US2002/161016; (2002); (A1) English, View in Reaxys
Melting Point (4) 1 of 4
Melting Point [°C]
122 - 124
Kauffmann,T. et al.; Chemische Berichte; vol. 98; (1965); p. 904 - 911, View in Reaxys
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2 of 4
Melting Point [°C]
116 - 118
Solvent (Melting Point)
propan-2-ol
Anderson,F.E. et al.; Journal of Medicinal and Pharmaceutical Chemistry; vol. 5; nb. 2; (1962); p. 221 - 230, View in Reaxys 3 of 4
Melting Point [°C]
118.5 - 119
Yashunskii,V.G.; Vasil'eva,V.G.; J. Gen. Chem. USSR (Engl. Transl.); vol. 30; (1960); p. 2754 - 2756,2736 - 2738, View in Reaxys 4 of 4
Melting Point [°C]
124 - 125
Solvent (Melting Point)
acetonitrile
Biel et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 2805,2810, 2813, View in Reaxys Pharmacological Data (1) 1 of 1
Comment (Pharmacological Data)
Bioactivities present
Kauffmann,T. et al.; Chemische Berichte; vol. 98; (1965); p. 904 - 911, View in Reaxys; Anderson,F.E. et al.; Journal of Medicinal and Pharmaceutical Chemistry; vol. 5; nb. 2; (1962); p. 221 - 230, View in Reaxys; Patent; Tam, Peter; Gesundheit, Neil; Wilson, Leland F.; US2002/161016; (2002); (A1) English, View in Reaxys; Yashunskii,V.G.; Vasil'eva,V.G.; J. Gen. Chem. USSR (Engl. Transl.); vol. 30; (1960); p. 2754 - 2756,2736 - 2738, View in Reaxys; Biel et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 2805,2810, 2813, View in Reaxys; Zhang, Jinzhu; Yin, Zhiwei; Leonard, Patrick; Wu, Jing; Sioson, Kate; Liu, Che; Lapo, Robert; Zheng, Shengping; Angewandte Chemie - International Edition; vol. 52; nb. 6; (2013); p. 1753 - 1757; Angew. Chem.; vol. 125; nb. 6; (2013); p. 1797 - 1801,5, View in Reaxys; Niemegeers; Lenaerts; Artois; Janssen; Archives Internationales de Pharmacodynamie et de Therapie; vol. 227; nb. 2; (1977); p. 238 - 253, View in Reaxys; Hsu; Huang; Waters; Journal of medicinal chemistry; vol. 16; nb. 5; (1973); p. 450 - 452, View in Reaxys; ; (2012); Type: Review, Lab: EFF_071212, Owner: EFFECT, Number: 000, Revision: 07.12.2012 00:00:00, View in Reaxys
Reaxys ID 3197503 View in Reaxys
HN
3/9 CAS Registry Number: 55-52-7; 52031-11-5 Chemical Name: ((S)-1-methyl-2-phenyl-ethyl)-hydrazine; ((S)-1-Methyl-2-phenyl-aethyl)-hydrazin Linear Structure Formula: C9H14N2 Molecular Formula: C9H14N2 Molecular Weight: 150.224 Type of Substance: isocyclic InChI Key: VXTWEDPZMSVFEF-QMMMGPOBSA-N Note:
NH 2
H
Boiling Point (1) Boiling Point [°C] 135 - 138
Pressure (Boiling Point) [Torr]
References
10
Biel et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 4995, View in Reaxys
Refractive Index (1) Refractive Index Wavelength (Refractive Index) [nm]
Temperature (Refractive Index) [°C]
References
1.5385
20
Biel et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 4995, View in Reaxys
589
Optical Rotatory Power (1) 1 of 1
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
c=5
Solvent (Optical Rotatory Power)
methanol
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Optical Rotatory Power [deg]
4.5
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
25
Biel et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 4995, View in Reaxys Mass Spectrometry (1) Location References Page/Page column 11
Patent; BASF SE; US2012/123155; (2012); (A1) English, View in Reaxys
Reaxys ID 3197504 View in Reaxys
HN
4/9 CAS Registry Number: 55-52-7; 52031-11-5 Chemical Name: ((R)-1-methyl-2-phenyl-ethyl)-hydrazine; ((R)-1-Methyl-2-phenyl-aethyl)-hydrazin Linear Structure Formula: C9H14N2 Molecular Formula: C9H14N2 Molecular Weight: 150.224 Type of Substance: isocyclic InChI Key: VXTWEDPZMSVFEF-MRVPVSSYSA-N Note:
NH 2
H
Boiling Point (1) Boiling Point [°C] 135 - 138
Pressure (Boiling Point) [Torr]
References
10
Biel et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 4995, View in Reaxys
Refractive Index (1) Refractive Index Wavelength (Refractive Index) [nm]
Temperature (Refractive Index) [°C]
References
1.5385
20
Biel et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 4995, View in Reaxys
589
Optical Rotatory Power (1) 1 of 1
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
c=5
Solvent (Optical Rotatory Power)
methanol
Optical Rotatory Power [deg]
-4.5
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
25
Biel et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 4995, View in Reaxys
Reaxys ID 3914574 View in Reaxys
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HN
CAS Registry Number: 66-05-7; 15573-15-6; 54779-57-6 Chemical Name: ((S)-1-methyl-2-phenyl-ethyl)-hydrazine; hydrochloride; ((S)-1-Methyl-2-phenyl-aethyl)-hydrazin; Hydrochlorid Linear Structure Formula: C9H14N2*ClH Molecular Formula: C9H14N2*ClH Molecular Weight: 186.684 Type of Substance: isocyclic InChI Key: HXCTUSBYMZQLKB-QRPNPIFTSA-N Note:
NH 2
H
Cl
H
Melting Point (3) 1 of 3
Melting Point [°C]
152 - 154
Solvent (Melting Point)
propan-2-ol
Biel et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 4995, View in Reaxys 2 of 3
Melting Point [°C]
152 - 154
Solvent (Melting Point)
acetonitrile
Biel et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 4995, View in Reaxys 3 of 3
Melting Point [°C]
148 - 149
Bernstein et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 4433, View in Reaxys Optical Rotatory Power (2) 1 of 2
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
c=1
Solvent (Optical Rotatory Power)
H2O
Optical Rotatory Power [deg]
13.8
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
25
Bernstein et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 4433, View in Reaxys 2 of 2
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
c=5
Solvent (Optical Rotatory Power)
H2O
Optical Rotatory Power [deg]
12.8
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
25
Biel et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 4995, View in Reaxys
Reaxys ID 3914575 View in Reaxys
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HN
CAS Registry Number: 66-05-7; 15573-15-6; 54779-57-6 Chemical Name: ((R)-1-methyl-2-phenyl-ethyl)-hydrazine; hydrochloride; ((R)-1-Methyl-2-phenyl-aethyl)-hydrazin; Hydrochlorid Linear Structure Formula: C9H14N2*ClH Molecular Formula: C9H14N2*ClH Molecular Weight: 186.684 Type of Substance: isocyclic InChI Key: HXCTUSBYMZQLKB-DDWIOCJRSA-N Note:
NH 2
H
Cl
H
Melting Point (3) 1 of 3
Melting Point [°C]
152 - 154
Solvent (Melting Point)
propan-2-ol
Biel et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 4995, View in Reaxys 2 of 3
Melting Point [°C]
152 - 154
Solvent (Melting Point)
acetonitrile
Biel et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 4995, View in Reaxys 3 of 3
Melting Point [°C]
148 - 149
Bernstein et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 4433, View in Reaxys Optical Rotatory Power (2) 1 of 2
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
c=1
Solvent (Optical Rotatory Power)
H2O
Optical Rotatory Power [deg]
-14
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
25
Bernstein et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 4433, View in Reaxys 2 of 2
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
c=5
Solvent (Optical Rotatory Power)
H2O
Optical Rotatory Power [deg]
-12.5
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
25
Biel et al.; Journal of the American Chemical Society; vol. 81; (1959); p. 4995, View in Reaxys
Reaxys ID 642974 View in Reaxys
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14CH
Derivative (1) Comment (Derivative) *HCl:F: 113-116grad(aus Acetonitril)
H N
Chemical Name: 2-Phenyl-isopropylhydrazin-1-14C Linear Structure Formula: C8 (14)CH14N2 Molecular Formula: C9H14N2 Molecular Weight: 152.213 Type of Substance: isocyclic InChI Key: VXTWEDPZMSVFEF-PPJXEINESA-N Note:
NH 2
References Eberson; Acta Chemica Scandinavica (1947-1973); vol. 17; (1963); p. 2349, View in Reaxys
Reaxys ID 6787300 View in Reaxys H N
NH 2
8/9
HO
Linear Structure Formula: C9H14N2*C2H2O4 Molecular Formula: C2H2O4*C9H14N2 Molecular Weight: 240.259 Type of Substance: isocyclic InChI Key: OZQVYCAIYOMQBM-UHFFFAOYSA-N Note:
O
O
OH
Melting Point (1) 1 of 1
Melting Point [°C]
172
Solvent (Melting Point)
ethanol
Kauffmann,T. et al.; Chemische Berichte; vol. 98; (1965); p. 904 - 911, View in Reaxys
Reaxys ID 25091446 View in Reaxys H N
9/9 Linear Structure Formula: C9H14N2*C10H12N2 Molecular Formula: C9H14N2*C10H12N2 Molecular Weight: 310.442 InChI Key: QTEJWXOAPILVRM-UHFFFAOYSA-N Note:
H 2N NH 2
HN
Pharmacological Data (1) 1 of 1
Comment (Pharmacological Data)
Bioactivities present
Lahti; Platz; McAllister; Journal of medicinal chemistry; vol. 13; nb. 4; (1970); p. 681 - 683, View in Reaxys
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