Query Query H
Results
Date
3 substances in Reaxys
2016-06-10 04h:59m:53s (EST)
1 substances in Reaxys
2016-06-10 05h:00m:14s (EST)
NH 2
1. Query
O
O
Search as: As drawn 2. Query
(1. Query) AND itemno in (2)
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2016-06-10 05:01:24
Reaxys ID 2429766 View in Reaxys
H
1/1 CAS Registry Number: 63038-26-6 Chemical Name: (S)-2-amino-3,3-dimethyl-butyric acid methyl ester; H-Tle-OMe; (S)-tert-butylglycine methyl ester; (S)-ter-leucine methyl ester; L-tert-leucine methyl ester; methyl L-tert-leucinate; methyl tert-leucinate Linear Structure Formula: C4H9CHNH2CO2CH3 Molecular Formula: C7H15NO2 Molecular Weight: 145.202 Type of Substance: acyclic InChI Key: WCYLIGGIKNKWQX-RXMQYKEDSA-N Note:
NH 2 O O
Substance Label (9) Label References 9c
Vasilakaki, Sofia; Barbayianni, Efrosini; Leonis, Georgios; Papadopoulos, Manthos G.; Mavromoustakos, Thomas; Gelb, Michael H.; Kokotos, George; Bioorganic and Medicinal Chemistry; vol. 24; nb. 8; (2016); p. 1683 - 1695, View in Reaxys
III
Patent; DIPHARMA FRANCIS S.R.L.; MANTEGAZZA, Simone; ATTOLINO, Emanuele; ALLEGRINI, Pietro; WO2013/131978; (2013); (A1) English, View in Reaxys
32
Bondada, Lavanya; Rondla, Ramu; Pradere, Ugo; Liu, Peng; Li, Chengwei; Bobeck, Drew; McBrayer, Tamara; Tharnish, Philip; Courcambeck, Jerome; Halfon, Philippe; Whitaker, Tony; Amblard, Franck; Coats, Steven J.; Schinazi, Raymond F.; Bioorganic and Medicinal Chemistry Letters; vol. 23; nb. 23; (2013); p. 6325 - 6330, View in Reaxys
3E-2
Patent; INTERMUNE, INC.; BUCKMAN, Brad; NICHOLAS, John, B.; SEREBRYANY, Vladimir; SEIWERT, Scott, D.; WO2012/40242; (2012); (A1) English, View in Reaxys
7q
Fujiwara, Tomoya; Segawa, Masaru; Fujisawa, Hidehito; Murai, Taiki; Takahashi, Tamiko; Omata, Kenji; Kabuto, Kuninobu; Lodwig, Siegfried N.; Unkefer, Clifford J.; Takeuchi, Yoshio; Tetrahedron Asymmetry; vol. 19; nb. 7; (2008); p. 847 - 856, View in Reaxys
126
Patent; Anadys Pharmaceuticals, Inc.; US2008/292588; (2008); (A1) English, View in Reaxys
5e
Bringmann, Gerhard; Scharl, Heiko; Maksimenka, Katja; Radacki, Krzysztof; Braunschweig, Holger; Wich, Peter; Schmuck, Carsten; European Journal of Organic Chemistry; nb. 19; (2006); p. 4349 - 4361, View in Reaxys
11a
Davies, Stephen J.; Ayscough, Andrew P.; Beckett, R. Paul; Clements, John M.; Doel, Sheila; Pratt, Lisa M.; Spavold, Zoe M.; Thomas, S. Wayne; Whittaker, Mark; Bioorganic and Medicinal Chemistry Letters; vol. 13; nb. 16; (2003); p. 2715 - 2718, View in Reaxys
L-1d
Knoelker, Hans-Joachim; Herzberg, Daniela; Tetrahedron Letters; vol. 40; nb. 18; (1999); p. 3547 - 3548, View in Reaxys
Patent-Specific Data (1) References Patent; DIPHARMA FRANCIS S.R.L.; MANTEGAZZA, Simone; ATTOLINO, Emanuele; ALLEGRINI, Pietro; WO2013/131978; (2013); (A1) English, View in Reaxys Boiling Point (2) Boiling Point [°C]
Pressure (Boiling Point) [Torr]
References
68
20
Pospisek,J.; Blaha,K.; Collection of Czechoslovak Chemical Communications; vol. 42; (1977); p. 1069 - 1076, View in Reaxys
69
16
Pracejus,H.; Winter,S.; Chemische Berichte; vol. 97; (1964); p. 3173 - 3182, View in Reaxys
Optical Rotatory Power (3) 1 of 3
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
0.82 g/100ml
Solvent (Optical Rotatory Power)
CHCl3
Optical Rotatory Power [deg]
62.9
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Wavelength (Optical Ro- 589 tatory Power) [nm] Speelman, Johanna C.; Talma, Auke G.; Kellogg, Richard M.; Meetsma, A.; Boer, J. L. de; et al.; Journal of Organic Chemistry; vol. 54; nb. 5; (1989); p. 1055 - 1062, View in Reaxys 2 of 3
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
0.82 g/100ml
Solvent (Optical Rotatory Power)
CHCl3
Optical Rotatory Power [deg]
65.7 - 232
Wavelength (Optical Ro- 365 - 578 tatory Power) [nm] Speelman, Johanna C.; Talma, Auke G.; Kellogg, Richard M.; Meetsma, A.; Boer, J. L. de; et al.; Journal of Organic Chemistry; vol. 54; nb. 5; (1989); p. 1055 - 1062, View in Reaxys 3 of 3
Type (Optical Rotatory Power)
[alpha]
Concentration (Optical Rotatory Power)
1 g/100ml
Solvent (Optical Rotatory Power)
ethanol
Optical Rotatory Power [deg]
64.5
Wavelength (Optical Ro- 589 tatory Power) [nm] Temperature (Optical Rotatory Power) [°C]
23
Pracejus,H.; Winter,S.; Chemische Berichte; vol. 97; (1964); p. 3173 - 3182, View in Reaxys NMR Spectroscopy (1) 1 of 1
Nucleus (NMR Spectroscopy)
1H
Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]
400
Original Text (NMR Spectroscopy)
1H
Location
Page/Page column 256
Comment (NMR Spectroscopy)
Signals given
NMR (400 MHz, CDC13): δ 3.68 (s, 3H), 3.14 (s, 1H), 0.94 (s, 9H).
Patent; INTERMUNE, INC.; BUCKMAN, Brad; NICHOLAS, John, B.; SEREBRYANY, Vladimir; SEIWERT, Scott, D.; WO2012/40242; (2012); (A1) English, View in Reaxys
Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.
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