1,2,4,5,6,7-hexa'ACH'-1H-indole-3-carbaldehyde

Page 1

Query Query ACH

Results

Date

3247 reactions in Reaxys

2016-08-04 14h:44m:45s (EST)

O

ACH

1. Query

ACH N

ACH ACH

ACH

Search as: As drawn, No mixtures, No isotopes, No charges, No radicals

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

1/428

2016-08-04 14:49:45


OH (v1)

NH 2 Pol

NH O

O

N

Pol

N

(v1)

O

O

Rx-ID: 31918132 View in Reaxys 1/3247

Cl

NH

NH

Cl Cl

O

Rx-ID: 44254 View in Reaxys 2/3247

NH

NH

N

O O

Rx-ID: 44327 View in Reaxys 3/3247

NH

NH

O

Rx-ID: 44390 View in Reaxys 4/3247

NH

NH

N

O

Rx-ID: 137221 View in Reaxys 5/3247

NH NH

N O

Rx-ID: 316123 View in Reaxys 6/3247

NH

OH NH

O EN

O

Rx-ID: 340383 View in Reaxys 7/3247

NH

O N

NH

Z OH O

Rx-ID: 340474 View in Reaxys 8/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

2/428

2016-08-04 14:49:45


NH O–

NH

O S

O

O

N+

O

Rx-ID: 546336 View in Reaxys 9/3247

NH

N O O

Rx-ID: 760026 View in Reaxys 10/3247

NH NH

NH 2 O

OH

O

Rx-ID: 813209 View in Reaxys 11/3247

H N

NH

NH N

O

Rx-ID: 1511976 View in Reaxys 12/3247

NH NH

S

S O

Rx-ID: 1556711 View in Reaxys 13/3247 -1 F (v4)

NH

F

B FF

NH

O+ O

O

Rx-ID: 1560042 View in Reaxys 14/3247 2 Cl – N+

NH

O

N N

O

N+

NH

N O

Cl

Rx-ID: 1560310 View in Reaxys 15/3247

NH

NH

O

Rx-ID: 1636906 View in Reaxys 16/3247

NH

NH

OH

O

Rx-ID: 1704272 View in Reaxys 17/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

3/428

2016-08-04 14:49:45


NH

NH

O O

O

OH

Rx-ID: 1799426 View in Reaxys 18/3247

NH

NH NH HN

O

Rx-ID: 2209303 View in Reaxys 19/3247

NH NH

N

O

N

Rx-ID: 2545219 View in Reaxys 20/3247 Z O HN N H

NH

N

OH O

OH O

L-isomer

Rx-ID: 2616398 View in Reaxys 21/3247 -1 F (v4)

F

B FF

NH N+

O NH

Rx-ID: 3066054 View in Reaxys 22/3247 -1 F (v4)

F

B FF

NH N+

N H O

NH

Rx-ID: 3066055 View in Reaxys 23/3247

NH O NH

2 O

O O

O

Rx-ID: 3177182 View in Reaxys 24/3247

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4/428

2016-08-04 14:49:45


NH NH

O

N

N

O

O

Rx-ID: 3480431 View in Reaxys 25/3247

NH NH

N N O

N N

Rx-ID: 3633025 View in Reaxys 26/3247

Si

NH

N

O

O

Rx-ID: 3646853 View in Reaxys 27/3247

O H 2N

O NH

H

O

H 2N O O

HN

Rx-ID: 3830568 View in Reaxys 28/3247

NH

NH

NH O

O

OH

Rx-ID: 3951973 View in Reaxys 29/3247

NH

O

NH

OH H

O

Rx-ID: 4065738 View in Reaxys 30/3247

Br NH

O

N

O

O

Rx-ID: 4278727 View in Reaxys 31/3247

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5/428

2016-08-04 14:49:45


Br O

NH

N O

O

Rx-ID: 4278932 View in Reaxys 32/3247

O

NH

O

N HO

O O

Rx-ID: 4538605 View in Reaxys 33/3247

NH

Si N

O O

Rx-ID: 4795255 View in Reaxys 34/3247 O S

O

NH

N

O O

Rx-ID: 4953417 View in Reaxys 35/3247 O O

N NH

N O

O

Rx-ID: 4961438 View in Reaxys 36/3247

NH

NH

O O

OH

Rx-ID: 5089038 View in Reaxys 37/3247

NH

NH

N

O

Rx-ID: 5188819 View in Reaxys 38/3247

NH

NH

S

O

Rx-ID: 5189556 View in Reaxys 39/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

6/428

2016-08-04 14:49:45


NH

O

Rx-ID: 5416552 View in Reaxys 40/3247

NH

3-diethylaminoethyl-indole O

Rx-ID: 5416553 View in Reaxys 41/3247

NH

NH H

O

O

H

air O

OH

Rx-ID: 5416554 View in Reaxys 42/3247

NH

indol-3-ylmethyl-trimethyl-ammonium sulfate O

Rx-ID: 5416555 View in Reaxys 43/3247

NH

indolyl-(3)-glyoxylic acid O

Rx-ID: 5416556 View in Reaxys 44/3247

NH

indolyl magnesium iodide

formic acid esters O

Rx-ID: 5416557 View in Reaxys 45/3247

NH

indolyl potassium

carbon monoxide O

Rx-ID: 5416558 View in Reaxys 46/3247 O O

O

indolyl magnesium iodide

N

NH

O

Rx-ID: 5416560 View in Reaxys 47/3247

O O

NH

N

O O

Rx-ID: 8998190 View in Reaxys 48/3247

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7/428

2016-08-04 14:49:45


NH

NH –

I N+

O

Rx-ID: 9010637 View in Reaxys 49/3247

NH

NH

NH

N

O

OH

N

Rx-ID: 9156856 View in Reaxys 50/3247

NH

NH

N

O

N

Rx-ID: 9157154 View in Reaxys 51/3247 O O

S

NH

N

O

O

Rx-ID: 9513878 View in Reaxys 52/3247

O NH

N

O

O

Rx-ID: 9582695 View in Reaxys 53/3247 O NH

N

O

O

Rx-ID: 9746326 View in Reaxys 54/3247

NH

NH

N

O

OH

Rx-ID: 9901537 View in Reaxys 55/3247

NH

NH O

O

Rx-ID: 10273335 View in Reaxys 56/3247

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8/428

2016-08-04 14:49:45


Cl NH

N

O

O

Rx-ID: 15268538 View in Reaxys 57/3247 Cl

NH N

O O

Rx-ID: 15268543 View in Reaxys 58/3247 Cl NH

N

O

O

Rx-ID: 15272007 View in Reaxys 59/3247

NH

NH

polyindole/s(?) O

Rx-ID: 17154338 View in Reaxys 60/3247

Si

NH

N O

Rx-ID: 17166239 View in Reaxys 61/3247

Si

NH

N

O Br

Rx-ID: 17169478 View in Reaxys 62/3247

Si

NH

N

O Li

Rx-ID: 17178337 View in Reaxys 63/3247

NH

NH

/PBHBF037--995/ O

Rx-ID: 18510065 View in Reaxys 64/3247

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9/428

2016-08-04 14:49:45


Si

NH

N

O

Rx-ID: 18645291 View in Reaxys 65/3247

Si

NH

N

O

Br

Rx-ID: 18684224 View in Reaxys 66/3247

NH

NH

<(η-chlorobenzene)(ηCp)Fe><PF6>

O

Rx-ID: 19351775 View in Reaxys 67/3247

NH

NH

O

O

Rx-ID: 26009908 View in Reaxys 68/3247

NH

NH

NH

O

OH

N

Rx-ID: 28828086 View in Reaxys 69/3247

NH

NH NH

O

S

S

Rx-ID: 29442983 View in Reaxys 70/3247

2

H

NH

NH

S

S NH

O

Rx-ID: 30417244 View in Reaxys 71/3247

NH

S NH S

S

NH

NH 2 S

O

Rx-ID: 30417247 View in Reaxys 72/3247

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10/428

2016-08-04 14:49:45


NH

NH NH

O

O

O

Rx-ID: 30417250 View in Reaxys 73/3247

NH

NH HN

O

Rx-ID: 31402588 View in Reaxys 74/3247

NH NH

NH O

Rx-ID: 31402608 View in Reaxys 75/3247

NH

NH

N

O

Rx-ID: 33111785 View in Reaxys 76/3247

NH

NH

N

N

O

Rx-ID: 33439649 View in Reaxys 77/3247

N

NH

N

O

Rx-ID: 33598352 View in Reaxys 78/3247

N

NH N

NH

N N

O

Rx-ID: 34129333 View in Reaxys 79/3247

O N

NH

N

N

O

Rx-ID: 34138113 View in Reaxys 80/3247

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11/428

2016-08-04 14:49:45


NH

NH

OH

O

O

Rx-ID: 35471714 View in Reaxys 81/3247 I

O N

NH

Cl O

O

O

Rx-ID: 35804570 View in Reaxys 82/3247 O NH

N

O

O

Rx-ID: 35858027 View in Reaxys 83/3247

NH

S

NH

O

O

Rx-ID: 36422512 View in Reaxys 84/3247

NH S

NH

O

S

O

Rx-ID: 36422515 View in Reaxys 85/3247

NH

NH

Cl – N+

O

Rx-ID: 37371213 View in Reaxys 86/3247

NH

NH

NH O O

O

OH

Rx-ID: 28206899 View in Reaxys 87/3247

NH

O

O– Na +

O

NH

O

O

Rx-ID: 51223 View in Reaxys 88/3247

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12/428

2016-08-04 14:49:45


NH

NH N

O

Rx-ID: 51226 View in Reaxys 89/3247

Cl

NH

Cl

NH

O– Na +

Cl O

Rx-ID: 51230 View in Reaxys 90/3247

Cl

NH

NH

Cl Cl

O

Rx-ID: 51231 View in Reaxys 91/3247

NH

O

NH

O

O

Rx-ID: 51236 View in Reaxys 92/3247

NH

NH

N

O O

Rx-ID: 51338 View in Reaxys 93/3247

Cl

NH

Cl

NH

Cl O

Rx-ID: 71642 View in Reaxys 94/3247

NH

NH

N

O

O

Rx-ID: 71649 View in Reaxys 95/3247

NH

O

N

O S

O

O

O

O

Rx-ID: 77660 View in Reaxys 96/3247

NH

N

O

O

Rx-ID: 77668 View in Reaxys 97/3247

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13/428

2016-08-04 14:49:45


O N

H N

O

NH 2

NH

O

E O

O

Rx-ID: 91136 View in Reaxys 98/3247 O NH

N

O

Rx-ID: 91137 View in Reaxys 99/3247

NH

NH O

O

O

OH

Rx-ID: 162551 View in Reaxys 100/3247

Cl

Cl

NH

NH

Cl O

Rx-ID: 339523 View in Reaxys 101/3247

NH

NH

N

O O

Rx-ID: 339527 View in Reaxys 102/3247

NH

O

NH

OH H

O

Rx-ID: 1575224 View in Reaxys 103/3247

N

N

N

O

O

Rx-ID: 1635471 View in Reaxys 104/3247

NH

N

N

O O

O

O

Rx-ID: 1647381 View in Reaxys 105/3247

NH

N

I O

O

Rx-ID: 1647439 View in Reaxys 106/3247

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14/428

2016-08-04 14:49:45


NH

NH

O

Rx-ID: 1656564 View in Reaxys 107/3247

NH

NH

O

F

Sn

O

F

Tl

O

F

F

O F

NH

O

O

O

F

Rx-ID: 2315907 View in Reaxys 108/3247

NH

NH

O

F

Tl

O

F

NH

O

O

F

F

O

O

O

F

F

Rx-ID: 2524930 View in Reaxys 109/3247

N

O

O

N

O

O

Rx-ID: 2603557 View in Reaxys 110/3247

N+

N

I– N

O

Rx-ID: 2628398 View in Reaxys 111/3247 -1 F (v4)

F

B FF

NH

O CH +

O

N H

Rx-ID: 2633813 View in Reaxys 112/3247

NH

NH

N

N

O

O

O

Rx-ID: 3484185 View in Reaxys 113/3247

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15/428

2016-08-04 14:49:45


N

O

N

O S

Z

O

O

N

O

Rx-ID: 3548220 View in Reaxys 114/3247

NH

NH Br

Sn

O

O

Rx-ID: 3952253 View in Reaxys 115/3247

NH

O

5-methyl-indolyl-(1 or 3)-magnesium iodide

O

O

Rx-ID: 5420805 View in Reaxys 116/3247

NH

O

Rx-ID: 5423556 View in Reaxys 117/3247

NH

α-amino-β-<2-methyl-indolyl-(3)>-propionic acid O

Rx-ID: 5423557 View in Reaxys 118/3247

NH

NH

Cl

H

N

O

O

Rx-ID: 5423558 View in Reaxys 119/3247

Cl

NH

Cl

H

NH

Cl

N

Cl O

Rx-ID: 5423559 View in Reaxys 120/3247

NH

NH H

O

H

NH 2

O

ferric chloride O

OH

Rx-ID: 5423560 View in Reaxys 121/3247

NH

potassium-compound of 2-methyl-indole

carbon monoxide O

Rx-ID: 5423561 View in Reaxys 122/3247

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16/428

2016-08-04 14:49:45


NH

NH

zinc cyanide O

Rx-ID: 5423562 View in Reaxys 123/3247

HN H

O

NH

NH

H

N

O

Rx-ID: 5423563 View in Reaxys 124/3247 O O

O

<2-methyl-indolyl-(1 or 3)>-magnesium iodide

N

NH

O

Rx-ID: 5423564 View in Reaxys 125/3247

N

O

Rx-ID: 5423660 View in Reaxys 126/3247

NH

O

Rx-ID: 5424488 View in Reaxys 127/3247

NH

O

Rx-ID: 5590564 View in Reaxys 128/3247

NH

O

Rx-ID: 6653065 View in Reaxys 129/3247

N

NH

N

I

O

O

Rx-ID: 8930397 View in Reaxys 130/3247

NH

NH I– N+

O

Rx-ID: 9048554 View in Reaxys 131/3247

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17/428

2016-08-04 14:49:45


NH

NH

N

O O

Rx-ID: 9238227 View in Reaxys 132/3247

NH

NH

N

O O

Rx-ID: 9239461 View in Reaxys 133/3247

N I

N

EN

O

Rx-ID: 9272521 View in Reaxys 134/3247

NH

NH N+

Cl

Cl –

O

Rx-ID: 10022420 View in Reaxys 135/3247 O O

O

<2-methyl-indolyl-(1or3)>-magnesium iodide

NH

N

O

Rx-ID: 10600051 View in Reaxys 136/3247

N

NH

fluorobenzene*Cr(CO)3 complex O

Rx-ID: 11766964 View in Reaxys 137/3247

N

N O

O

H OH

O HOHO

O

Rx-ID: 14357291 View in Reaxys 138/3247

N

N

OH

O

O

Rx-ID: 14384220 View in Reaxys 139/3247

NH

NH

O

Rx-ID: 19063571 View in Reaxys 140/3247

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18/428

2016-08-04 14:49:45


NH

N

<(η-chlorobenzene)(ηCp)Fe><PF6>

O

Rx-ID: 19527034 View in Reaxys 141/3247

NH

N

O

Rx-ID: 19527340 View in Reaxys 142/3247

N

N

Z N

O

Rx-ID: 20159025 View in Reaxys 143/3247

N

NH

permanganate O

potassium permanganate O

OH

Rx-ID: 20168197 View in Reaxys 144/3247

NH

NH O

air

potassium permanganate

O

O

Rx-ID: 20176090 View in Reaxys 145/3247

NH

NH

O

Rx-ID: 24138536 View in Reaxys 146/3247

NH

O

N

O

1-methylindole-3-carboxalehyde

O O

O

Rx-ID: 24274903 View in Reaxys 147/3247

N

N-(3-methylene-1-methylindole)aniline O

Rx-ID: 25284791 View in Reaxys 148/3247

NH

NH

NH

Br

O

Sn O

O

Rx-ID: 28628838 View in Reaxys 149/3247

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19/428

2016-08-04 14:49:45


NH

NH

NH

NH 2 O

OH

O

O

Rx-ID: 31007025 View in Reaxys 150/3247

NH

NH HN

O

Rx-ID: 31402590 View in Reaxys 151/3247

NH

NH HN

O

Rx-ID: 31402592 View in Reaxys 152/3247

NH

NH HN

O

Rx-ID: 31402611 View in Reaxys 153/3247

N

N

N

N

O

O

N

Rx-ID: 31476338 View in Reaxys 154/3247

N

NH

O

Rx-ID: 32107569 View in Reaxys 155/3247

NH

O

N

O O

O

O

Rx-ID: 32107613 View in Reaxys 156/3247

N

N HN

O

Rx-ID: 33111787 View in Reaxys 157/3247

N

N

O

Rx-ID: 33199459 View in Reaxys 158/3247

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2016-08-04 14:49:45


N

S

N

O

O

Rx-ID: 33199465 View in Reaxys 159/3247

N

N

O

Rx-ID: 33199468 View in Reaxys 160/3247

N N

O

O

Rx-ID: 33199486 View in Reaxys 161/3247

N

N

O

NH 2

Rx-ID: 33199494 View in Reaxys 162/3247

NH

O N O

O

Rx-ID: 33420587 View in Reaxys 163/3247

N

N

N

N

O

Rx-ID: 33439653 View in Reaxys 164/3247

NH

N

methyl derivative O

O

Rx-ID: 34442114 View in Reaxys 165/3247

NH

N

methyl halide O

O

Rx-ID: 34567155 View in Reaxys 166/3247

NH

N

methyl halogenide O

O

Rx-ID: 35294517 View in Reaxys 167/3247

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21/428

2016-08-04 14:49:45


NH

NH

O

S

O

Rx-ID: 36422514 View in Reaxys 168/3247

NH

O

N

O O

O

O

Rx-ID: 36626967 View in Reaxys 169/3247

NH

N

S O

O

Rx-ID: 37094240 View in Reaxys 170/3247

NH

N

DM S O

O

Rx-ID: 37250111 View in Reaxys 171/3247

N+

N Cl –

N

O

Rx-ID: 37371215 View in Reaxys 172/3247

NH

NH Cl – N+

O

Rx-ID: 37371216 View in Reaxys 173/3247

N

N

O

Rx-ID: 37371225 View in Reaxys 174/3247

O

S

O

N

NE O

N

Rx-ID: 38436989 View in Reaxys 175/3247

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22/428

2016-08-04 14:49:45


O

N

S O

N

N N

O N

Rx-ID: 38436992 View in Reaxys 176/3247

N N

O

Rx-ID: 38437018 View in Reaxys 177/3247

N HN

O

Rx-ID: 38437073 View in Reaxys 178/3247

N

H 2N O

Rx-ID: 38437119 View in Reaxys 179/3247

NH

NH

N

N

O

Rx-ID: 38902993 View in Reaxys 180/3247

NH

NH

N

N

O

Rx-ID: 38903000 View in Reaxys 181/3247

N

N

N

O

Rx-ID: 40466735 View in Reaxys 182/3247

NH

NH

N

O

Rx-ID: 40466737 View in Reaxys 183/3247

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23/428

2016-08-04 14:49:45


N

N

N O O

Rx-ID: 41148972 View in Reaxys 184/3247

NH

NH

N

O H 2N

H 2N

O

Rx-ID: 1640615 View in Reaxys 185/3247

NH NH 2 O

Rx-ID: 5821616 View in Reaxys 186/3247

NH

NH N

O

HO

HO

O

Rx-ID: 1640631 View in Reaxys 187/3247

NH

I

NH

O

OH

O

Rx-ID: 1795875 View in Reaxys 188/3247

NH

F

NH

O

F

O

Tl

O

O

F

F

O F

OH

O

F

Rx-ID: 2524933 View in Reaxys 189/3247

NH

NH

O

OH

O

Rx-ID: 4718448 View in Reaxys 190/3247

Si

OH N

O N

O O

Rx-ID: 4743580 View in Reaxys 191/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

24/428

2016-08-04 14:49:45


OH N

O

Rx-ID: 6588933 View in Reaxys 192/3247

NH

NH

O

O

OH

O

Rx-ID: 9064348 View in Reaxys 193/3247 OH

O O

N

N

O O

O

Rx-ID: 9552098 View in Reaxys 194/3247 OH

OH

N

N O

O

Rx-ID: 17241110 View in Reaxys 195/3247

Si

OH N

O N

O

Rx-ID: 17263200 View in Reaxys 196/3247

Si

OH N

O N O

O

Rx-ID: 17263356 View in Reaxys 197/3247 OH

NH

N

O

Rx-ID: 21631145 View in Reaxys 198/3247 OH N

OH N

O

Rx-ID: 21631265 View in Reaxys 199/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

25/428

2016-08-04 14:49:45


NH

NH

N

O OH

OH

O

Rx-ID: 22830594 View in Reaxys 200/3247

NH

OH

O

Rx-ID: 25104809 View in Reaxys 201/3247

NH

NH

OH

OH

O

Rx-ID: 25402899 View in Reaxys 202/3247

N

N

N O

O

O

O

Rx-ID: 28206905 View in Reaxys 203/3247 OH

O NH

N

N

O

O

O

Rx-ID: 28628845 View in Reaxys 204/3247 OH

O

N

N

O

O

Rx-ID: 28628846 View in Reaxys 205/3247

HO

HO

NH N

NH

O

O

Rx-ID: 34515961 View in Reaxys 206/3247

HO

NH

O

Rx-ID: 36393339 View in Reaxys 207/3247

NH

NH

NH

OH

O

O

OH

Rx-ID: 38868250 View in Reaxys 208/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

26/428

2016-08-04 14:49:45


NH

NH

N

O F

F

O

Rx-ID: 1640647 View in Reaxys 209/3247

F

F

NH

N

NH

O O

Rx-ID: 4607434 View in Reaxys 210/3247

NH F O

Rx-ID: 6588054 View in Reaxys 211/3247

F

NH

O

Rx-ID: 6588154 View in Reaxys 212/3247

NH

F

O

Rx-ID: 6588931 View in Reaxys 213/3247 F

F

NH

NH

N

O

O

Rx-ID: 10023022 View in Reaxys 214/3247

NH

NH

N

O F

F

O

Rx-ID: 10491886 View in Reaxys 215/3247

F

O

N

NH

F O

O

Rx-ID: 17417887 View in Reaxys 216/3247 O O

N

N

NH F

E F

O

Rx-ID: 17418061 View in Reaxys 217/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

27/428

2016-08-04 14:49:45


O N

NH

F

O

F O

Rx-ID: 17418576 View in Reaxys 218/3247

F

N

F

NH

E

O

N

O

O

Rx-ID: 17424601 View in Reaxys 219/3247 F

F

NH

NH

O

Rx-ID: 23322831 View in Reaxys 220/3247

NH

NH HN

F

F

O

Rx-ID: 31402595 View in Reaxys 221/3247

N

NH N

NH

N

F

F

N

O

Rx-ID: 34129332 View in Reaxys 222/3247

NH

S

NH

O F

F

O

Rx-ID: 36422513 View in Reaxys 223/3247

NH

NH

N

N

F

F

O

Rx-ID: 38903001 View in Reaxys 224/3247

NH F

Cl

O

O

Cl

NH F O

Rx-ID: 40166087 View in Reaxys 225/3247

NH

NH

N

O F O

Rx-ID: 41493386 View in Reaxys 226/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

28/428

2016-08-04 14:49:45


NH

NH

NH

NH

NH

O

O

O O

OH

OH

OH

Rx-ID: 1789346 View in Reaxys 227/3247

NH

NH

NH

NH

O O

OH

O

OH

OH

Rx-ID: 5190214 View in Reaxys 228/3247

Cl

NH

NH

N

Cl

alcoholic KOH-solution

Cl

Cl

O

Rx-ID: 5416559 View in Reaxys 229/3247

NH NH

O O

Si

Rx-ID: 3993690 View in Reaxys 230/3247

NH

NH

I

O

O

Rx-ID: 11708846 View in Reaxys 231/3247

NH

NH

O

Br

Rx-ID: 12138502 View in Reaxys 232/3247

NH

NH

Br

O

O

Rx-ID: 12152292 View in Reaxys 233/3247 O

O

Si NH

NH

Rx-ID: 31850218 View in Reaxys 234/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

29/428

2016-08-04 14:49:45


O NH Br

NH O

Rx-ID: 31850220 View in Reaxys 235/3247

NH

NH

N O

O N

N

Rx-ID: 92370 View in Reaxys 236/3247

NH O

N N

O

N

Rx-ID: 1554542 View in Reaxys 237/3247 N

N

NH

NH

N

O O

Rx-ID: 1655840 View in Reaxys 238/3247

NH

NH

N

O N

N

O

Rx-ID: 1656727 View in Reaxys 239/3247 O

N

N

NH N

O

Rx-ID: 1746984 View in Reaxys 240/3247

NH

NH N

I

Cu

(v1)

O

O

N

Rx-ID: 1795871 View in Reaxys 241/3247 O

NH

N N

O

N

K

O

Rx-ID: 1796365 View in Reaxys 242/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

30/428

2016-08-04 14:49:45


NH

NH N

Cu

O

F

(v1)

Tl

O

F

O

O

F

O

F

O

N F

F

Rx-ID: 2258112 View in Reaxys 243/3247 N NH N

N

Br

O

O

Rx-ID: 4859930 View in Reaxys 244/3247

NH

N

O

Rx-ID: 5592573 View in Reaxys 245/3247

NH N

O

Rx-ID: 5593996 View in Reaxys 246/3247 N

N

NH

N

NH

O

O

Rx-ID: 10023828 View in Reaxys 247/3247 N

N

NH

NH

O

Rx-ID: 23513343 View in Reaxys 248/3247 N NH

O

Rx-ID: 23959631 View in Reaxys 249/3247

NH

NH

N

N

O

Rx-ID: 23994795 View in Reaxys 250/3247 N

N

NH

NH HN

O

Rx-ID: 31402601 View in Reaxys 251/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

31/428

2016-08-04 14:49:45


O

NH

N –C

N

N

K+

O

O

Rx-ID: 35858043 View in Reaxys 252/3247

NH

NH

N

O O N

N

Rx-ID: 36381425 View in Reaxys 253/3247

N+

N

NH

Cl – N

NH

O

Rx-ID: 36669261 View in Reaxys 254/3247

NH

NH

N

N

N

N

O

Rx-ID: 38903011 View in Reaxys 255/3247 O

O

NH

NH O

O

Rx-ID: 3347295 View in Reaxys 256/3247

NH

N

Br

Cl

O

O

Rx-ID: 9180860 View in Reaxys 257/3247

Br

NH

F

F B–

HN

K+

F

O

O

Rx-ID: 33590256 View in Reaxys 258/3247

OH

NH

O

NH

OH

O

Rx-ID: 1796347 View in Reaxys 259/3247

O

NH

O

Rx-ID: 6588731 View in Reaxys 260/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

32/428

2016-08-04 14:49:45


NH

NH

O

O O

Rx-ID: 24894740 View in Reaxys 261/3247 O NH

N

N

O

O NH

Rx-ID: 38903009 View in Reaxys 262/3247 O

O NH

N

O N H O

Rx-ID: 41759778 View in Reaxys 263/3247 O

O O N H

N O

O

Rx-ID: 41759791 View in Reaxys 264/3247 O O

O

N

O

N H

O

O

Rx-ID: 41759839 View in Reaxys 265/3247

N

N

N O O

Rx-ID: 82397 View in Reaxys 266/3247

NH

O

N

O S

O

O

O

O

Rx-ID: 104568 View in Reaxys 267/3247

NH

N –O

Na +

I

O

O

Rx-ID: 104570 View in Reaxys 268/3247

NH

NH

N

O O

Rx-ID: 1643528 View in Reaxys 269/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

33/428

2016-08-04 14:49:45


NH

NH

O

Rx-ID: 1643530 View in Reaxys 270/3247

NH

N

Br

O

O

Rx-ID: 1647204 View in Reaxys 271/3247

NH

NH

B

O

O

Rx-ID: 1647224 View in Reaxys 272/3247

NH

N

I

O

O

Rx-ID: 1647333 View in Reaxys 273/3247

N

N

N

O

O

Rx-ID: 1655415 View in Reaxys 274/3247

NH

N

I O

O

Rx-ID: 1703407 View in Reaxys 275/3247

N

N

I

O

O

Rx-ID: 1704193 View in Reaxys 276/3247 O NH

N

B

O

O

Rx-ID: 1796359 View in Reaxys 277/3247

N

N

O

O

Rx-ID: 3658842 View in Reaxys 278/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

34/428

2016-08-04 14:49:45


NH

NH

O

N

Rx-ID: 5205305 View in Reaxys 279/3247

N

O

Rx-ID: 5434771 View in Reaxys 280/3247

NH

O

Rx-ID: 6589709 View in Reaxys 281/3247

NH

O

Rx-ID: 6589799 View in Reaxys 282/3247

NH

O

Rx-ID: 6653817 View in Reaxys 283/3247

NH

O

Rx-ID: 6654275 View in Reaxys 284/3247

NH

N

ethyl halide O

O

Rx-ID: 8501367 View in Reaxys 285/3247

N

N Br

N

I

O

Br

O

Rx-ID: 9204783 View in Reaxys 286/3247

NH

NH

N

O

O

Rx-ID: 9937982 View in Reaxys 287/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

35/428

2016-08-04 14:49:45


O NH

I N O

Rx-ID: 10492413 View in Reaxys 288/3247 O NH

I N O

Rx-ID: 10552734 View in Reaxys 289/3247 O N

N

O N

Rx-ID: 11172154 View in Reaxys 290/3247 O NH

N

Rx-ID: 11767668 View in Reaxys 291/3247 O

NH

N

Rx-ID: 11774817 View in Reaxys 292/3247

N

NH

O

Rx-ID: 14204569 View in Reaxys 293/3247

NH

N

2,4-Cl2C6H3CH2X O

O

Rx-ID: 16167456 View in Reaxys 294/3247 Cl N

N

O

O

Rx-ID: 16201353 View in Reaxys 295/3247

NH

N

O

Rx-ID: 19527655 View in Reaxys 296/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

36/428

2016-08-04 14:49:45


NH

N

O

O

Rx-ID: 24003060 View in Reaxys 297/3247 NH O

Rx-ID: 24239940 View in Reaxys 298/3247

NH

N

CH3 I O O

Rx-ID: 24292568 View in Reaxys 299/3247

N O

Rx-ID: 25783223 View in Reaxys 300/3247

N

N

O

Rx-ID: 25842215 View in Reaxys 301/3247 O

N N

Rx-ID: 25843178 View in Reaxys 302/3247

N

NH

O

Rx-ID: 32449533 View in Reaxys 303/3247

N

N

N

O

O

Rx-ID: 32449535 View in Reaxys 304/3247

NH

O

O

N

S O

O

O

O

Rx-ID: 32682123 View in Reaxys 305/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

37/428

2016-08-04 14:49:45


NH

NH

HN

O

Rx-ID: 33111790 View in Reaxys 306/3247

N

S

N

O

O

Rx-ID: 33199466 View in Reaxys 307/3247 O

N

S

O

N

Rx-ID: 33199467 View in Reaxys 308/3247

N

N

N O

O

Rx-ID: 33199473 View in Reaxys 309/3247

NH

N

NH

O

O

Rx-ID: 33420527 View in Reaxys 310/3247

NH

O N O

O

Rx-ID: 33420585 View in Reaxys 311/3247

N

N

N

N

O

Rx-ID: 33439670 View in Reaxys 312/3247

Br

NH

NH O

O

Rx-ID: 33590317 View in Reaxys 313/3247

NH

HN O

O

Rx-ID: 33590430 View in Reaxys 314/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

38/428

2016-08-04 14:49:45


N

N

N

O

Rx-ID: 33598353 View in Reaxys 315/3247

N

N

N

N

N N

O

Rx-ID: 34129320 View in Reaxys 316/3247 O

N

N

N

N

Rx-ID: 34138114 View in Reaxys 317/3247

N

N

N

N

O

Rx-ID: 34138115 View in Reaxys 318/3247

N

N

N

N

O

Rx-ID: 34138116 View in Reaxys 319/3247

N

N

N

N

O

Rx-ID: 34138126 View in Reaxys 320/3247

N

S

N

O

O

Rx-ID: 36422517 View in Reaxys 321/3247

NH

N S O

O

Rx-ID: 37094242 View in Reaxys 322/3247

NH

N

DES O

O

Rx-ID: 37250110 View in Reaxys 323/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

39/428

2016-08-04 14:49:45


O N

N

N

N

Rx-ID: 38026963 View in Reaxys 324/3247

O

S

N

O

NE O N

Rx-ID: 38436986 View in Reaxys 325/3247

O S O

N

N

N N

O N

Rx-ID: 38437006 View in Reaxys 326/3247

N N

O

Rx-ID: 38437044 View in Reaxys 327/3247

N HN

O

Rx-ID: 38437074 View in Reaxys 328/3247

N

H 2N O

Rx-ID: 38437120 View in Reaxys 329/3247

NH

N

I O O

Rx-ID: 40491024 View in Reaxys 330/3247

N

NH

O

Rx-ID: 40491045 View in Reaxys 331/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

40/428

2016-08-04 14:49:45


N

N

N

O O

Rx-ID: 40834277 View in Reaxys 332/3247

N

N

N

O

O

Rx-ID: 40834278 View in Reaxys 333/3247

N

NH

O

Rx-ID: 40834416 View in Reaxys 334/3247

NH

NH

N

O O

Rx-ID: 42319521 View in Reaxys 335/3247 O

N Z

NH

NH

H N H

O

O

NH

Rx-ID: 1796384 View in Reaxys 336/3247 N N

N

N

N

NH 2 O

O

Rx-ID: 2773188 View in Reaxys 337/3247

NH

NH

N H

O I

NH

O

O

Rx-ID: 5085840 View in Reaxys 338/3247

NH

NH

2,4-Cl2C6H3CH2X NH

O

O

Rx-ID: 16513709 View in Reaxys 339/3247

N

N Cl

O

NH 2 O

Rx-ID: 20380830 View in Reaxys 340/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

41/428

2016-08-04 14:49:45


NH

NH

N

N

NH

O

O

O

Z O

O

O

Rx-ID: 4725 View in Reaxys 341/3247

O

O

NH

N

NH

O O

Rx-ID: 82565 View in Reaxys 342/3247

NH

NH N

HO

HO

O

Rx-ID: 82811 View in Reaxys 343/3247

NH

NH

N

O O

O

O

Rx-ID: 82995 View in Reaxys 344/3247

NH

NH

NH

OH

O

O O

OH

O

OH

Rx-ID: 208214 View in Reaxys 345/3247 OH

O

N

N

N

N O

O

Rx-ID: 1462113 View in Reaxys 346/3247

NH

NH –O

Na +

O

O

O

Rx-ID: 1647271 View in Reaxys 347/3247 O

O NH

N

NH

O

O

Rx-ID: 1706950 View in Reaxys 348/3247

NH

NH

N O

O

O

O

Rx-ID: 1707337 View in Reaxys 349/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

42/428

2016-08-04 14:49:45


O

NH

O

NH

O

O

O

O

Rx-ID: 1707339 View in Reaxys 350/3247

NH

NH –

Na +

O

I

O

O

O

Rx-ID: 1795872 View in Reaxys 351/3247

OH

NH

OH

NH

OH

O

Rx-ID: 1796348 View in Reaxys 352/3247 O NH

N –O

O

Na +

O

O

Rx-ID: 1796362 View in Reaxys 353/3247 O NH

N

O

O

O

Rx-ID: 1796369 View in Reaxys 354/3247

NH NH

O N

N

O

O

O

O

Rx-ID: 2977488 View in Reaxys 355/3247 O

O

N

N

N

O

O

Rx-ID: 3342471 View in Reaxys 356/3247

NH

N

I OH

O

OH

O

Rx-ID: 3902722 View in Reaxys 357/3247 +

NH

NH

NH

NH

(v2)

NH

N

O OH

O

O–

CH 2

OH

O

O OH

Rx-ID: 3951974 View in Reaxys 358/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

43/428

2016-08-04 14:49:45


NH O O

Rx-ID: 5433249 View in Reaxys 359/3247

O

NH

O

Rx-ID: 5433444 View in Reaxys 360/3247

NH H

O

N

H

aqueous isopropyl alcohol

H

OH

O

NH

NH

O O

OH

Rx-ID: 5441526 View in Reaxys 361/3247 O N

O

Rx-ID: 6591252 View in Reaxys 362/3247

Si O

O

NH

N

O

O

Rx-ID: 8714854 View in Reaxys 363/3247

Si

NH

N O

O

O

O

Rx-ID: 8714855 View in Reaxys 364/3247

NH

Si N

O O

O

O

Rx-ID: 8716743 View in Reaxys 365/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

44/428

2016-08-04 14:49:45


NH

NH –

O

I

O

N+

O

Rx-ID: 9048555 View in Reaxys 366/3247 O

NH N

O O

O

O

Rx-ID: 9617273 View in Reaxys 367/3247 O

O

N

N

O

N

Rx-ID: 9676756 View in Reaxys 368/3247

NH NH

O O

O

O

O

Rx-ID: 9746740 View in Reaxys 369/3247

NH

NH O

O

O

O

Rx-ID: 10277179 View in Reaxys 370/3247

O

NH

O

O

NH

OH

O

Rx-ID: 13380418 View in Reaxys 371/3247

NH

NH

OH

O

O

O

O

Rx-ID: 13380441 View in Reaxys 372/3247 O

O NH

O

NH

OH

O

Rx-ID: 13380815 View in Reaxys 373/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

45/428

2016-08-04 14:49:45


OH

NH

NH

O O

O

O

Rx-ID: 13380834 View in Reaxys 374/3247

NH

O

NH

O

O

O

O

Rx-ID: 13380988 View in Reaxys 375/3247 O

O

NH

O

NH

O

O

Rx-ID: 13383652 View in Reaxys 376/3247

O

NH

NH

O O

O

O

Rx-ID: 13383680 View in Reaxys 377/3247

O

O

O

NH

NH

O O

Rx-ID: 13389033 View in Reaxys 378/3247

O

O O

NH

O

Z N

N

N

O

Rx-ID: 13389858 View in Reaxys 379/3247

O

NH

α-hydrazino-phenylacetic acid

O O

O

Rx-ID: 13390307 View in Reaxys 380/3247 O

O

NH

Z

O N

N

O

N

O

Rx-ID: 13392306 View in Reaxys 381/3247

O

O

NH

(S)-(Fmoc-amino)-(4-fluoro-phenyl)-acetic acid on Wang resin

O O

Rx-ID: 13393174 View in Reaxys 382/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

46/428

2016-08-04 14:49:45


O O

O

NH

(S)-(Fmoc-amino)-(4-fluoro-phenyl)-acetic acid on Wang resin

O

Rx-ID: 13393175 View in Reaxys 383/3247

NH

(S)-(Fmoc-amino)-cyclohexyl-acetic acid on Wang resin O

O

O

O

Rx-ID: 13393314 View in Reaxys 384/3247 O

N

NH

O

Z

O

N

O O

N

Rx-ID: 13403186 View in Reaxys 385/3247 O

O O

Z

O N

N

NH

N

O

Rx-ID: 13403187 View in Reaxys 386/3247 N

O

N

O

O N

O O

O

Rx-ID: 13525338 View in Reaxys 387/3247 O

F

N

O N O

O

Rx-ID: 13526531 View in Reaxys 388/3247

O

O O

N

N

OH

O N

Rx-ID: 13539864 View in Reaxys 389/3247

O

O O

N

N

O

O N

Rx-ID: 13540850 View in Reaxys 390/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

47/428

2016-08-04 14:49:45


O

O

N

N

O O

O O N

O

O

Rx-ID: 13543018 View in Reaxys 391/3247 O O

O

N

N

O O

O

Rx-ID: 13837519 View in Reaxys 392/3247 O

NH

N

O

Rx-ID: 15540652 View in Reaxys 393/3247

O

O

NH

NH

O

Rx-ID: 15540867 View in Reaxys 394/3247

NH

NH

O

O

O

Rx-ID: 15540877 View in Reaxys 395/3247

NH

NH

O

O

O

Rx-ID: 15541179 View in Reaxys 396/3247

Si

NH

N O

O

O

Rx-ID: 15556603 View in Reaxys 397/3247

Si O

O

NH

N

O

Rx-ID: 15559329 View in Reaxys 398/3247

Si O

O

NH

N

Br

O

Rx-ID: 15559371 View in Reaxys 399/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

48/428

2016-08-04 14:49:45


Si

NH

N O

O

O

Br

Rx-ID: 15562172 View in Reaxys 400/3247

NH

Si N

O

O

O

Rx-ID: 15566350 View in Reaxys 401/3247

NH

Si N

O

O

Br

O

Rx-ID: 15568074 View in Reaxys 402/3247

O N

OH

O

NH

2-nitro-m-cresol; 6-nitro-m-cresol

O O

Rx-ID: 18009558 View in Reaxys 403/3247

O N

NH

O

O

O O

Rx-ID: 18012693 View in Reaxys 404/3247

NH

NH

O

I

O

Rx-ID: 19021699 View in Reaxys 405/3247

NH

I

N

O

OH

O

Rx-ID: 19838561 View in Reaxys 406/3247 OH N

O N

O

Rx-ID: 20166799 View in Reaxys 407/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

49/428

2016-08-04 14:49:45


O N

O

anhydroformaldehyde o-toluidine

N O

O

Rx-ID: 20171134 View in Reaxys 408/3247 O N

N

O

O N

E

O

Rx-ID: 20171477 View in Reaxys 409/3247

O

NH

ethyl magnesium halide

O O

O

Rx-ID: 20265518 View in Reaxys 410/3247

NH

NH

O

O

Rx-ID: 21631144 View in Reaxys 411/3247 OH NH

N

O

O

Rx-ID: 21631264 View in Reaxys 412/3247

NH

O N

O

O O

Rx-ID: 21649418 View in Reaxys 413/3247

O N

O N

O O

Rx-ID: 21649419 View in Reaxys 414/3247 O N

O N O

O

Rx-ID: 21759165 View in Reaxys 415/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

50/428

2016-08-04 14:49:45


NH

NH

O

O

O

Rx-ID: 22167985 View in Reaxys 416/3247 O

O

NH

NH

O

Rx-ID: 23336583 View in Reaxys 417/3247 O NH

O

Rx-ID: 24679419 View in Reaxys 418/3247 OH

NH

N

O O

O

Rx-ID: 24726577 View in Reaxys 419/3247 O OH

N O

N O

Rx-ID: 25593089 View in Reaxys 420/3247

N

N

O

O

OH

O

Rx-ID: 25612426 View in Reaxys 421/3247

NH

O

O

Rx-ID: 27791587 View in Reaxys 422/3247

NH

O

Cl

O

O

Cl

NH

O

O

Rx-ID: 29004396 View in Reaxys 423/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

51/428

2016-08-04 14:49:45


O

O

NH

NH

HN

O

Rx-ID: 31402600 View in Reaxys 424/3247

NH

NH HN

O

O

O

Rx-ID: 31402602 View in Reaxys 425/3247

NH

NH HN

O

O

O

Rx-ID: 31402605 View in Reaxys 426/3247

NH

NH HO

HO

O

Rx-ID: 33419520 View in Reaxys 427/3247

N

NH N

NH

N

O

O

N

O

Rx-ID: 34129331 View in Reaxys 428/3247

NH

NH

O

OH

O

Rx-ID: 34564157 View in Reaxys 429/3247

NH

NH

O

O

Rx-ID: 34994163 View in Reaxys 430/3247 O NH

N

O

HO

O

O

Rx-ID: 35858047 View in Reaxys 431/3247 O N

N

O

O N

O

Rx-ID: 37210222 View in Reaxys 432/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

52/428

2016-08-04 14:49:45


O

O

N

NH N

NH

N N

O

Rx-ID: 38126464 View in Reaxys 433/3247 O

O

N

NH

N

NH

N N

O

Rx-ID: 38126465 View in Reaxys 434/3247

NH

NH

N N

N N

O

O

O

Rx-ID: 38126469 View in Reaxys 435/3247

NH

NH

N

N

O

O

O

Rx-ID: 38902996 View in Reaxys 436/3247

NH O

Cl

O

O

Cl

NH O O

Rx-ID: 40166107 View in Reaxys 437/3247 O

O

N

N

N

O

Rx-ID: 40466736 View in Reaxys 438/3247

NH

NH

O

O

N

O

Rx-ID: 40466738 View in Reaxys 439/3247

NH

O O

N

N

NH

H N

O

O

O

N

O

OH

O

O N H

O

Rx-ID: 9156266 View in Reaxys 440/3247

NH F O

Rx-ID: 6591185 View in Reaxys 441/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

53/428

2016-08-04 14:49:45


F

F

NH

N

I O

O

Rx-ID: 9174330 View in Reaxys 442/3247

NH

N

I F

F O

O

Rx-ID: 10552730 View in Reaxys 443/3247

NH

N

I F

O

F

O

Rx-ID: 10552731 View in Reaxys 444/3247

N

NH

F

F

O

Rx-ID: 11767742 View in Reaxys 445/3247

NH

N

F

F

O

Rx-ID: 11767910 View in Reaxys 446/3247

F

F

NH

N

O

Rx-ID: 14686735 View in Reaxys 447/3247

NH

NH HN

F

H 2N

F

F

O

Rx-ID: 25272644 View in Reaxys 448/3247

N

F

O

Rx-ID: 25358786 View in Reaxys 449/3247

F N

N

F

O

Rx-ID: 25397343 View in Reaxys 450/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

54/428

2016-08-04 14:49:45


NH

NH

N

O F

F

O

Rx-ID: 28118701 View in Reaxys 451/3247

O

F NH

Rx-ID: 28908942 View in Reaxys 452/3247

F

N N

N

O

F

O

Rx-ID: 31479027 View in Reaxys 453/3247

N

N

N

O F

F

O

Rx-ID: 32612542 View in Reaxys 454/3247

N

N

N

N

F

F

O

Rx-ID: 34138118 View in Reaxys 455/3247

F N

N

N

N F

O

Rx-ID: 34138119 View in Reaxys 456/3247

N

S

N

O F

F

O

Rx-ID: 36422498 View in Reaxys 457/3247

S N

O

F

N

F

O

Rx-ID: 36422499 View in Reaxys 458/3247

NH

NH S

SH O

O

O

Rx-ID: 4873733 View in Reaxys 459/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

55/428

2016-08-04 14:49:45


NH

NH

S

SH

N

O

Rx-ID: 28766549 View in Reaxys 460/3247

NH

N

NH

Cl

O

Rx-ID: 71654 View in Reaxys 461/3247

NH

O

NH

O Cl

Cl

O

O

Rx-ID: 332570 View in Reaxys 462/3247

NH

NH N

O

Cl

Cl

O

Rx-ID: 379562 View in Reaxys 463/3247

NH

NH

O

Cl

O

Rx-ID: 1647446 View in Reaxys 464/3247

NH

NH

Cl

Cl

O

Rx-ID: 1650399 View in Reaxys 465/3247 O

O

NH

N

N

Cl

N O

O

O

Rx-ID: 1735238 View in Reaxys 466/3247

OH

O

N O

Si

NH

N

Cl

N

O

O

Rx-ID: 1926317 View in Reaxys 467/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

56/428

2016-08-04 14:49:45


OH

NH

N

Cl

O

N

O

N

O

O

O

Rx-ID: 1926318 View in Reaxys 468/3247

NH

N

O

O

N

S

Cl

O

O

O

Rx-ID: 1926319 View in Reaxys 469/3247

NH

NH

N

O

Cl

O

O

Rx-ID: 4607667 View in Reaxys 470/3247

NH

Cl

O

Rx-ID: 5430373 View in Reaxys 471/3247

NH Cl

O

Rx-ID: 6047872 View in Reaxys 472/3247

Cl

NH

O

Rx-ID: 6653309 View in Reaxys 473/3247 Cl NH

O

Rx-ID: 6653738 View in Reaxys 474/3247

Cl

Cl

NH N

NH

O

O

Rx-ID: 9239541 View in Reaxys 475/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

57/428

2016-08-04 14:49:45


NH

NH

N

O Cl

Cl

O

Rx-ID: 10491887 View in Reaxys 476/3247

NH

NH

O

O

Cl

O

Rx-ID: 20168342 View in Reaxys 477/3247

NH

Cl

NH

O

O

Cl

O

Rx-ID: 20199852 View in Reaxys 478/3247

NH

O

NH

Cl

OH

Cl

O

Rx-ID: 22215046 View in Reaxys 479/3247

NH

O

NH

O

Cl

Cl

O

Rx-ID: 22218163 View in Reaxys 480/3247 O

O

N

O

NH HO

Cl

O

O

Cl

Rx-ID: 22223909 View in Reaxys 481/3247

NH

POCl3

Cl

O N

O

Rx-ID: 22876636 View in Reaxys 482/3247 Cl

Cl

NH

NH

O

Rx-ID: 23315998 View in Reaxys 483/3247

Cl

NH

Cl

NH

O

Rx-ID: 23322120 View in Reaxys 484/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

58/428

2016-08-04 14:49:45


NH

NH

Cl

Cl

O

Rx-ID: 24131426 View in Reaxys 485/3247

NH Cl

O N

O

Rx-ID: 24590360 View in Reaxys 486/3247 Cl

Cl

NH

NH

N

O

O

Rx-ID: 25753402 View in Reaxys 487/3247

NH Cl O

Rx-ID: 27791588 View in Reaxys 488/3247

NH O

N

O

S

Cl

O

O

N

O

Rx-ID: 28628848 View in Reaxys 489/3247

NH

NH

Br

Cl O

O

Rx-ID: 30831796 View in Reaxys 490/3247

Cl

Cl

NH

NH

HN

O

Rx-ID: 31402593 View in Reaxys 491/3247

NH

NH HN

Cl

Cl

O

Rx-ID: 31402612 View in Reaxys 492/3247

Cl

Cl

NH N

NH

N

O

Rx-ID: 38903005 View in Reaxys 493/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

59/428

2016-08-04 14:49:45


Cl

O

O

Cl

NH

NH

Cl

Cl

O

Rx-ID: 40166089 View in Reaxys 494/3247 NH F

NH

F

O F

F

Rx-ID: 24133676 View in Reaxys 495/3247 NH F

O F

Rx-ID: 27739052 View in Reaxys 496/3247 NH F

N

NH

O

F

O F

F

Rx-ID: 27791356 View in Reaxys 497/3247

N

N

Br Z N

O

Rx-ID: 9408942 View in Reaxys 498/3247

N

N Si

O

O

Rx-ID: 10248513 View in Reaxys 499/3247

N

N Br

O

O

Rx-ID: 12378820 View in Reaxys 500/3247

NH

N

propargyl halide O

O

Rx-ID: 29851184 View in Reaxys 501/3247

NH Br

O

N

O

Rx-ID: 29955581 View in Reaxys 502/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

60/428

2016-08-04 14:49:45


N NH

NH

N

O

N

O

Rx-ID: 1704626 View in Reaxys 503/3247

N

N

N

N

N

O

O

Rx-ID: 2741544 View in Reaxys 504/3247 O

NH

N

I N

N

O

Rx-ID: 10520755 View in Reaxys 505/3247 O

NH

N N

N

Rx-ID: 11768024 View in Reaxys 506/3247

N

N

N

O

Rx-ID: 18423970 View in Reaxys 507/3247 O O

S

N

N

N N

O

Rx-ID: 18439304 View in Reaxys 508/3247

O

N

O

NH

N

O

N

Rx-ID: 20060462 View in Reaxys 509/3247

O

N

O

NH N

N

O

Rx-ID: 20060509 View in Reaxys 510/3247 O N

NH

N N

O HN

Rx-ID: 27900022 View in Reaxys 511/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

61/428

2016-08-04 14:49:45


N NH

N

I N

O O

Rx-ID: 29000186 View in Reaxys 512/3247 O

N

S

O

N N

N

Rx-ID: 36422509 View in Reaxys 513/3247 O

N

N

N

N N

N

Rx-ID: 38902989 View in Reaxys 514/3247

OH N

O

N

O

Rx-ID: 1612489 View in Reaxys 515/3247

NH

N

Br

O

O

Rx-ID: 1647364 View in Reaxys 516/3247

NH

N

allyl halide O

O

Rx-ID: 29851181 View in Reaxys 517/3247

NH

N

O

Rx-ID: 32945902 View in Reaxys 518/3247

N

N

N

N

O

Rx-ID: 34138112 View in Reaxys 519/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

62/428

2016-08-04 14:49:45


O NH

Br

N

O

Rx-ID: 36406798 View in Reaxys 520/3247 O

O

N

N

Rx-ID: 38895588 View in Reaxys 521/3247

NH

NH

N

E

O O

Rx-ID: 41867910 View in Reaxys 522/3247 O

N

N

O N

Rx-ID: 41867912 View in Reaxys 523/3247 O

N O

N

Rx-ID: 41867913 View in Reaxys 524/3247 O NH

N

O NH

Rx-ID: 41867918 View in Reaxys 525/3247 O O

O

S N NH

Rx-ID: 41867923 View in Reaxys 526/3247 O O

S

NH

E

N

O

Rx-ID: 41867924 View in Reaxys 527/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

63/428

2016-08-04 14:49:45


O

O S

O

N

OH

NH

Rx-ID: 41867933 View in Reaxys 528/3247

O S

NH

E

O

N

OH

O

Rx-ID: 41867936 View in Reaxys 529/3247

NH NH O

F

Tl

O

F

O

O

F

F

O

N

N

N

O

F

F

Rx-ID: 2524932 View in Reaxys 530/3247 O

N

NH

N

O NH

N

N

N

N

N

Rx-ID: 31808424 View in Reaxys 531/3247 N

N

N

N

NH

N

HN O

O

O

Rx-ID: 8905960 View in Reaxys 532/3247

O NH

O

O

O

N

O

O

Rx-ID: 1647286 View in Reaxys 533/3247

N

O

O

N

O O

O

Rx-ID: 2659959 View in Reaxys 534/3247 H N

O

NH

O O

O

Rx-ID: 2759032 View in Reaxys 535/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

64/428

2016-08-04 14:49:45


-1 F

O

(v4)

F

B FF

N

N

N+ N

O

O

Rx-ID: 3597776 View in Reaxys 536/3247

O NH

O

Cl

N

O

O

Rx-ID: 4510107 View in Reaxys 537/3247

O

NH

Cl N

O

O

NH

NH

NH

O

NH

O O

O

O

O

Rx-ID: 4923626 View in Reaxys 538/3247 O

O

NH

NH

Cl N

O

O

NH

NH

O O

O

O

Rx-ID: 4923628 View in Reaxys 539/3247

NH

NH

NH

O

N

OH

O

Rx-ID: 5212000 View in Reaxys 540/3247 O

O N

NH

NH

O

O

OH

N

Rx-ID: 5227436 View in Reaxys 541/3247

O N

O

Rx-ID: 5441630 View in Reaxys 542/3247

O

NH

O

Rx-ID: 6590037 View in Reaxys 543/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

65/428

2016-08-04 14:49:45


O

N

N

N

O

I I

O

Rx-ID: 8767604 View in Reaxys 544/3247

O

N

NH

MeX O

Rx-ID: 15497521 View in Reaxys 545/3247

O

N

NH I

O

Rx-ID: 15498305 View in Reaxys 546/3247

O

N

NH I I

O

Rx-ID: 15498530 View in Reaxys 547/3247

Cl

N

O

N

Cl O

O

Rx-ID: 21333067 View in Reaxys 548/3247 O N

N

N

O

O

N

Rx-ID: 34138123 View in Reaxys 549/3247

O

NH

N

O

Rx-ID: 34567101 View in Reaxys 550/3247

O NH

acetyl halide

N

O

O

Rx-ID: 34567154 View in Reaxys 551/3247

O N

O N

OH

O

Rx-ID: 35667444 View in Reaxys 552/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

66/428

2016-08-04 14:49:45


NH

NH

NH

O

Cl

NH

H 2N

H

O

O

Rx-ID: 3491015 View in Reaxys 553/3247 NH

N NH

NH

H 2N

O

Rx-ID: 19147032 View in Reaxys 554/3247 NH

N NH

NH

H 2N

O

O

Rx-ID: 19167001 View in Reaxys 555/3247

NH

NH

N

O O

Rx-ID: 1645167 View in Reaxys 556/3247

NH

NH

N

O O

Rx-ID: 1645198 View in Reaxys 557/3247

N

N

N

O

O

Rx-ID: 1664320 View in Reaxys 558/3247

N

NH

NH

O

O

Rx-ID: 3343643 View in Reaxys 559/3247

O

NH

NH

N

E

Si

O

HO

O

Rx-ID: 3857440 View in Reaxys 560/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

67/428

2016-08-04 14:49:45


NH

Cl

N

O

O

Rx-ID: 4067493 View in Reaxys 561/3247

NH

O

Rx-ID: 6590382 View in Reaxys 562/3247

NH

O

Rx-ID: 6654654 View in Reaxys 563/3247

N

O

Rx-ID: 6655901 View in Reaxys 564/3247

N

N

N

O

O

Rx-ID: 9333252 View in Reaxys 565/3247

N

NH

O

Rx-ID: 14213883 View in Reaxys 566/3247

O

NH 2

Cl

NH

O

Rx-ID: 21841436 View in Reaxys 567/3247

NH 2

NH

O

Rx-ID: 21854922 View in Reaxys 568/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

68/428

2016-08-04 14:49:45


N

O

Rx-ID: 23456241 View in Reaxys 569/3247 O

N

Rx-ID: 25026589 View in Reaxys 570/3247

N

N

O

O

N

Rx-ID: 28300613 View in Reaxys 571/3247

NH

N

I

O

O

Rx-ID: 29668033 View in Reaxys 572/3247

NH

N

O

Rx-ID: 32945901 View in Reaxys 573/3247

NH

N

O

Rx-ID: 32945904 View in Reaxys 574/3247

NH

N

isopropyl halide O

O

Rx-ID: 32945939 View in Reaxys 575/3247

NH

N

n-propyl halide O

O

Rx-ID: 32945941 View in Reaxys 576/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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2016-08-04 14:49:45


O NH N

Rx-ID: 33439651 View in Reaxys 577/3247 O

NH N

Rx-ID: 33439656 View in Reaxys 578/3247 O

NH

N

Rx-ID: 33439659 View in Reaxys 579/3247 O N

N

N

N

Rx-ID: 33439679 View in Reaxys 580/3247 O N

N

N

N

Rx-ID: 33439682 View in Reaxys 581/3247 O

N

N

N

N

Rx-ID: 33439685 View in Reaxys 582/3247

NH

N

propyl halide O

O

Rx-ID: 36255900 View in Reaxys 583/3247

NH

Br

N

O

O

Rx-ID: 36406796 View in Reaxys 584/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

70/428

2016-08-04 14:49:45


NH

I

N

O

O

Rx-ID: 37556761 View in Reaxys 585/3247

N

N

N

N

O

Rx-ID: 38026957 View in Reaxys 586/3247 O NH

N

O HN

Rx-ID: 42319522 View in Reaxys 587/3247 N

F

N

N

NH

O

NH F

O

Rx-ID: 29059261 View in Reaxys 588/3247 N F

N

NH

NH

O F

N

O

Rx-ID: 29059262 View in Reaxys 589/3247 F F

N

O

O

N

HN N

NH

Rx-ID: 29059263 View in Reaxys 590/3247 N

N

F

NH

N

F

O

NH

O

Rx-ID: 29059266 View in Reaxys 591/3247

NH NH

H 2N

O

NH I

O

O O

Rx-ID: 5104112 View in Reaxys 592/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

71/428

2016-08-04 14:49:45


O

NH NH

O

Rx-ID: 5596227 View in Reaxys 593/3247

NH NH

2,4-Cl2C6H3CH2X NH

O

O O

Rx-ID: 16513710 View in Reaxys 594/3247

N

N

N

NH 2

N N

O

O

Rx-ID: 4200336 View in Reaxys 595/3247

N

N NH 2

NH 2

S

O

Rx-ID: 4585620 View in Reaxys 596/3247

NH N O

Rx-ID: 5593375 View in Reaxys 597/3247

NH N

O

Rx-ID: 5594903 View in Reaxys 598/3247

O

NH

OH

NH

O

O O

O

Rx-ID: 293878 View in Reaxys 599/3247 O N

O

H N

NH

O

OH

O

O

OH

Rx-ID: 1797986 View in Reaxys 600/3247

N

NH N

HO

N

NH HO

N

O

O

O

Rx-ID: 4075273 View in Reaxys 601/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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NH

OH

NH

O

O

O O

Rx-ID: 17835541 View in Reaxys 602/3247

NH

OH

NH

O

O

OH O

Rx-ID: 22282908 View in Reaxys 603/3247 NH O O OH

Rx-ID: 25480956 View in Reaxys 604/3247 O O

NH

O

O OH NH

O

Rx-ID: 27874018 View in Reaxys 605/3247

NH

NH

N

HO

O

HO O

O

O

Rx-ID: 34464138 View in Reaxys 606/3247

N

NH

N

N

N

O

O

O

Z O

O

O

Rx-ID: 4726 View in Reaxys 607/3247

NH

N O

I

O

O

O

Rx-ID: 139388 View in Reaxys 608/3247

NH NH

O– Na +

O

O

O

Rx-ID: 1647273 View in Reaxys 609/3247

O

NH

N

O

Cl

O

O

Rx-ID: 1647334 View in Reaxys 610/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

73/428

2016-08-04 14:49:45


O

O

NH

N

NH

O O

Rx-ID: 1659853 View in Reaxys 611/3247

NH

NH

N

O O

O

O

Rx-ID: 1662309 View in Reaxys 612/3247

NH

O

N

O S

O

O

O

O

O

O

Rx-ID: 1751857 View in Reaxys 613/3247 O N

NH

O– Na +

O

O

O

Rx-ID: 1796364 View in Reaxys 614/3247

N

N

N

O O

O

O

Rx-ID: 3949827 View in Reaxys 615/3247

O

O N

N

N

O

O

Rx-ID: 4178917 View in Reaxys 616/3247

NH

NH

N

O O

O

O

Rx-ID: 4244036 View in Reaxys 617/3247

NH

N

I O

O O

O

Rx-ID: 4719861 View in Reaxys 618/3247

NH NH

O

O

O

Rx-ID: 5137000 View in Reaxys 619/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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2016-08-04 14:49:45


N HO O

Rx-ID: 5596311 View in Reaxys 620/3247

NH O O

Rx-ID: 6654445 View in Reaxys 621/3247

N O O

Rx-ID: 6655653 View in Reaxys 622/3247

NH O O

Rx-ID: 6655679 View in Reaxys 623/3247

NH

NH

Vilsmeier-reagent

O

O

O

Rx-ID: 6655680 View in Reaxys 624/3247 OH NH

N

Br

OH

O

O

Rx-ID: 8742268 View in Reaxys 625/3247 O

O

O

N

N

N

N

O O

O

Rx-ID: 8767555 View in Reaxys 626/3247

O

O

N

O

NH

NH

O

Rx-ID: 9263324 View in Reaxys 627/3247

O

O

N

N

N

O

O

Rx-ID: 10025220 View in Reaxys 628/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

75/428

2016-08-04 14:49:45


O O NH

I N O

O

Rx-ID: 10497267 View in Reaxys 629/3247

NH

NH

N

O

O

O

O

Rx-ID: 10534089 View in Reaxys 630/3247

NH

N

I O

O

O

O

Rx-ID: 10552821 View in Reaxys 631/3247

NH NH

O

O

OH

Rx-ID: 11767923 View in Reaxys 632/3247

N

NH

O

O

O

Rx-ID: 11768023 View in Reaxys 633/3247 O O NH

N O

Rx-ID: 11768496 View in Reaxys 634/3247

NH

O

N

O

O

Rx-ID: 11768498 View in Reaxys 635/3247

OH

O NH

NH

O

Rx-ID: 12909711 View in Reaxys 636/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

76/428

2016-08-04 14:49:45


O N

NH

OH

2-nitro-m-cresol; 6-nitro-m-cresol

O

O O

Rx-ID: 18009565 View in Reaxys 637/3247

NH

O N

O

O

O

O

Rx-ID: 18012541 View in Reaxys 638/3247 O O

N

O

NH

O O

O

Rx-ID: 19497649 View in Reaxys 639/3247 N+

N

O

N

O

O– O

HO

NH

S OO O

O

Rx-ID: 19518621 View in Reaxys 640/3247

H 2N O

O

N

NH

O O

O

Rx-ID: 19525787 View in Reaxys 641/3247 O

OH

NH

Rx-ID: 22820857 View in Reaxys 642/3247

NH

NH O

O

O

Rx-ID: 24652667 View in Reaxys 643/3247

NH

NH

NH O

O

O

Rx-ID: 24882270 View in Reaxys 644/3247

O

O

NH

N

NaH(11.3 mm) O

O

Rx-ID: 25524701 View in Reaxys 645/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

77/428

2016-08-04 14:49:45


O

O N

N

N

O

O

Rx-ID: 29604151 View in Reaxys 646/3247

O

NH

O

O

O

N

S O

O

O

O

Rx-ID: 32682211 View in Reaxys 647/3247 O O N

S

O

N O

Rx-ID: 33199475 View in Reaxys 648/3247

N

N

N

N

O

O

O

Rx-ID: 34138117 View in Reaxys 649/3247 O N

NH

OH

O

O

O

Rx-ID: 35858029 View in Reaxys 650/3247

N

S

N

O

O

O

O

Rx-ID: 36422516 View in Reaxys 651/3247

NH

N

S O O

O

Rx-ID: 37094241 View in Reaxys 652/3247

NH

N

DM S

O

O

O

O

Rx-ID: 37250113 View in Reaxys 653/3247 OH

OH

N

N

N

N

O

Rx-ID: 38026959 View in Reaxys 654/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

78/428

2016-08-04 14:49:45


O

O

N

N

N

N

O

Rx-ID: 38026964 View in Reaxys 655/3247

O

O

NH

N

O

Rx-ID: 40649199 View in Reaxys 656/3247

O

O

NH

N

I O

O

Rx-ID: 40649202 View in Reaxys 657/3247

N

O

O

NH

O NH

O

Rx-ID: 42105485 View in Reaxys 658/3247 O NH

N

O

NH

O

O

Rx-ID: 77670 View in Reaxys 659/3247 O NH

NH

NH

O N

O

O

O

N

O

N

O

O

NH

O

Rx-ID: 1647448 View in Reaxys 660/3247 O

O N

O

NH

N

O

O

N

NH

O

Rx-ID: 1760001 View in Reaxys 661/3247

NH

NH

N

O

N

O

O

O

N

O

O

Rx-ID: 1760059 View in Reaxys 662/3247

NH

NH O

N N O

O

O

N O

O

Rx-ID: 2330696 View in Reaxys 663/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

79/428

2016-08-04 14:49:45


NH

NH

O O

N

OO

O

OH

N

O

O

Rx-ID: 2442238 View in Reaxys 664/3247

NH NH

O O

F

N O O

N

N F

F

F

N

O

F

O

O

F

Rx-ID: 2466792 View in Reaxys 665/3247 O O

O

N

NH

O

N

NH

O O

O

OH

Rx-ID: 2788081 View in Reaxys 666/3247

NH

O

NH N

O O

O

Rx-ID: 5258186 View in Reaxys 667/3247 O N

O

NH

O

Rx-ID: 5456883 View in Reaxys 668/3247 O

N

O NH

O

Rx-ID: 6657329 View in Reaxys 669/3247

NH

O

N

O

O

Rx-ID: 6657336 View in Reaxys 670/3247

NH O

N O

O

Rx-ID: 6657339 View in Reaxys 671/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

80/428

2016-08-04 14:49:45


O N

O

NH

NH 2

O

N

O

O

Rx-ID: 11644565 View in Reaxys 672/3247

NH

N

O

NH

O

O

N

O

O

Rx-ID: 21794915 View in Reaxys 673/3247 O

N

O

N

NH

N N

O O

O

Rx-ID: 21797428 View in Reaxys 674/3247

NH O

N

N

N

O

N

O

O

O

Rx-ID: 21798226 View in Reaxys 675/3247

NH

O

N

N

O

O

O

N

O

O

Rx-ID: 21802483 View in Reaxys 676/3247 O O

O

N

NH

N

O

NH

O O

O

O

Rx-ID: 21804927 View in Reaxys 677/3247 O O

O N

NH

O

HO N N

O

N

O

O

Rx-ID: 21805655 View in Reaxys 678/3247 O N

OH O

O

Z O

O

O

N

NH

N N

O

Rx-ID: 21806070 View in Reaxys 679/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

81/428

2016-08-04 14:49:45


NH

NH O N

O

OO

O

O

N

O

O

Rx-ID: 21814012 View in Reaxys 680/3247 O NH 2

O

O

N

NH

N O

O

Rx-ID: 21815432 View in Reaxys 681/3247 O

O

O

N

N

O NH

NH

O

Rx-ID: 24072615 View in Reaxys 682/3247

NH

NH

N

O

N

O

N

O

O

O

O

Rx-ID: 24515573 View in Reaxys 683/3247 O

O

O

N

NH

N

O

N

NH

O

O

Rx-ID: 28248573 View in Reaxys 684/3247 O

O O

N

O

NH

OH

O

N

NH

O

Rx-ID: 35319150 View in Reaxys 685/3247

NH

NH

N

N

O

O

N O

N O

O

Rx-ID: 38903007 View in Reaxys 686/3247 O O O

OH

N

N

O O

O O

Rx-ID: 9552802 View in Reaxys 687/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

82/428

2016-08-04 14:49:45


O

O

O

O

N

O

N

O

OH

O

Rx-ID: 11206734 View in Reaxys 688/3247 O

OH HN

O

O

O NH

O

Rx-ID: 24293732 View in Reaxys 689/3247 O NH

N –S

S

Na + O

O

Rx-ID: 1796363 View in Reaxys 690/3247

NH

NH

N

S

S

O O

Rx-ID: 4735745 View in Reaxys 691/3247

NH N

NH

SH

N

S

O

O

Rx-ID: 4855498 View in Reaxys 692/3247

N

N S

N

SH

O

O

Rx-ID: 10222328 View in Reaxys 693/3247

NH

NH

S

O

Rx-ID: 15540658 View in Reaxys 694/3247 O

NH

N

S

O

Rx-ID: 15541428 View in Reaxys 695/3247

NH

NH

S

S O

Rx-ID: 16349780 View in Reaxys 696/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

83/428

2016-08-04 14:49:45


NH

NH

S

O O

Rx-ID: 17196040 View in Reaxys 697/3247

HN

NH

S

S

O

Rx-ID: 24145015 View in Reaxys 698/3247

O

Cl

NH

O

Cl

O

N

Cl

NH

Cl

O

Rx-ID: 82563 View in Reaxys 699/3247

Cl

NH

Cl

O

NH

N

Cl O

O

Cl

O

Rx-ID: 82990 View in Reaxys 700/3247

O

O

O

Cl

NH

Cl

NH

N

Cl Cl

O

Rx-ID: 106043 View in Reaxys 701/3247

NH

NH

N

O Cl

Cl

O

Rx-ID: 1656454 View in Reaxys 702/3247

O

NH

O

O

N Cl

S

Cl

O O

O

Rx-ID: 3549673 View in Reaxys 703/3247

N

N O

N

Cl

O

O

Rx-ID: 4609032 View in Reaxys 704/3247

NH

N Cl

O

I

Cl

O

Rx-ID: 4637790 View in Reaxys 705/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

84/428

2016-08-04 14:49:45


Cl NH

O

Rx-ID: 6591055 View in Reaxys 706/3247

NH Cl O

Rx-ID: 6591492 View in Reaxys 707/3247

N Cl

O

Rx-ID: 6655833 View in Reaxys 708/3247 Cl

Cl

N

N

N

O

O

Rx-ID: 10058037 View in Reaxys 709/3247

NH

N

I Cl

Cl O

O

Rx-ID: 10494276 View in Reaxys 710/3247

NH

N

I Cl

O

Cl

O

Rx-ID: 10495174 View in Reaxys 711/3247 O

Cl

NH

I Cl

O

N

Rx-ID: 10552735 View in Reaxys 712/3247 O

Cl

NH

N

Cl

Rx-ID: 11767738 View in Reaxys 713/3247

NH

Cl

N

Cl

O

Rx-ID: 11767913 View in Reaxys 714/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

85/428

2016-08-04 14:49:45


N

NH

Cl

Cl

O

Rx-ID: 11775899 View in Reaxys 715/3247 Cl

Cl

N

NH

O

Rx-ID: 12732471 View in Reaxys 716/3247

N Cl

HN

O

Rx-ID: 13394986 View in Reaxys 717/3247

N

N

Cl

Cl

O O

Rx-ID: 13395851 View in Reaxys 718/3247 Cl N

O

Rx-ID: 23288001 View in Reaxys 719/3247 OH

Cl

N

N

O

O

Rx-ID: 24734500 View in Reaxys 720/3247

N

N

Cl

Cl

O

Rx-ID: 25405537 View in Reaxys 721/3247

NH

NH Cl

Cl

O

Rx-ID: 29479795 View in Reaxys 722/3247

NH Cl

NH N

O

Cl O

Rx-ID: 32140501 View in Reaxys 723/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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N

N N

O

Cl

Cl

O

Rx-ID: 32612683 View in Reaxys 724/3247

N

N

N O Cl

O

Rx-ID: 33365835 View in Reaxys 725/3247

N

N

N

N

O O

Cl

Cl

O

Rx-ID: 33365843 View in Reaxys 726/3247

N

N

N

N

Cl

Cl

O

Rx-ID: 34138120 View in Reaxys 727/3247 O

Cl

N

N

N

N

Cl

Rx-ID: 34138121 View in Reaxys 728/3247

N

NH

Cl

O

O

Rx-ID: 36090843 View in Reaxys 729/3247 O

Cl

N

S

O

Cl

N

Rx-ID: 36422506 View in Reaxys 730/3247

N Cl

S

N

O

Cl O

Rx-ID: 36422507 View in Reaxys 731/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

87/428

2016-08-04 14:49:45


O S O

N

N

N Cl

N

Cl

O

N

Rx-ID: 38436996 View in Reaxys 732/3247

O

S

N

O

NE

Cl

Cl

O N

Rx-ID: 38437014 View in Reaxys 733/3247

N N

Cl

Cl O

Rx-ID: 38437027 View in Reaxys 734/3247

N HN

Cl

Cl O

Rx-ID: 38437093 View in Reaxys 735/3247

N Cl

NH 2

Cl O

Rx-ID: 38437153 View in Reaxys 736/3247

Cl

N

N

N

O

Cl

O

Rx-ID: 40834279 View in Reaxys 737/3247

NH Cl HO O

Rx-ID: 6593470 View in Reaxys 738/3247 OH Cl

N

O

Rx-ID: 6593640 View in Reaxys 739/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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2016-08-04 14:49:45


NH

NH

N

O

Cl

O HO

HO

O

Rx-ID: 9062868 View in Reaxys 740/3247 O

O

Cl

Cl

O

N

N

O

OH

O

Rx-ID: 11206733 View in Reaxys 741/3247 O

N

O N

C

O

Rx-ID: 29955594 View in Reaxys 742/3247 F O

Cl NH

Rx-ID: 27739443 View in Reaxys 743/3247 F

Cl N

NH O

O

Cl

F NH

Rx-ID: 29626278 View in Reaxys 744/3247

Cl

Cl

NH 2 F

F O

NH

Rx-ID: 41827439 View in Reaxys 745/3247 F Cl

Cl

NH 2 O

F O

NH

Cl

Rx-ID: 41827443 View in Reaxys 746/3247

Cl Cl NH

N

O F

F

O

NH

Rx-ID: 41827452 View in Reaxys 747/3247 Cl NH F

O

F NH

Rx-ID: 42105390 View in Reaxys 748/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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2016-08-04 14:49:45


Cl

NH

N

O

F

O F

NH

Cl

Rx-ID: 42105562 View in Reaxys 749/3247

O

Cl

Si

F

N NH

F

Rx-ID: 42105605 View in Reaxys 750/3247

O

Cl

Si

F

N

NH

F Cl

Rx-ID: 42105610 View in Reaxys 751/3247 N

NH

N N O

O

Rx-ID: 77653 View in Reaxys 752/3247 N NH

NH

N

O

N

O

Rx-ID: 3344962 View in Reaxys 753/3247

O

N

O

NH

N

O

N

Rx-ID: 20060464 View in Reaxys 754/3247

O

N

O

NH

N

N

O

Rx-ID: 20060511 View in Reaxys 755/3247

O

N

O

NH

N

N

O

Rx-ID: 20067268 View in Reaxys 756/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

90/428

2016-08-04 14:49:45


O N

NH

N

N

Rx-ID: 33439667 View in Reaxys 757/3247 O N N

N

N

N

N

Rx-ID: 33439698 View in Reaxys 758/3247 N NH

N

Br

N

O O

Rx-ID: 37943341 View in Reaxys 759/3247 I

C

N

N

N

O

O

O

O

O

Rx-ID: 5271147 View in Reaxys 760/3247

NH

O O

HO

NH

Rx-ID: 30217951 View in Reaxys 761/3247

O

NH

N

O

O O

NH

Rx-ID: 30217965 View in Reaxys 762/3247

NH

NH

N+

O

Rx-ID: 2563985 View in Reaxys 763/3247

NH

NH

N

O

O

Rx-ID: 3342606 View in Reaxys 764/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

91/428

2016-08-04 14:49:45


O

NH

O

NH

O

O

Rx-ID: 3347332 View in Reaxys 765/3247

N

N

N

O

O

Rx-ID: 9670584 View in Reaxys 766/3247

NH

N

Br O

O

Rx-ID: 9937630 View in Reaxys 767/3247

N

O Cl

NH NH

Rx-ID: 10463104 View in Reaxys 768/3247 O NH

N

O NH

Rx-ID: 11113306 View in Reaxys 769/3247

NH N

Br

O O

Rx-ID: 11197412 View in Reaxys 770/3247 O

NH NH

Rx-ID: 11438654 View in Reaxys 771/3247 O NH

NH

Rx-ID: 11920070 View in Reaxys 772/3247

O

NH

O

Rx-ID: 20784929 View in Reaxys 773/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

92/428

2016-08-04 14:49:45


NH HN H 2N

O

Rx-ID: 20820167 View in Reaxys 774/3247

NH N

N

O

Rx-ID: 21591510 View in Reaxys 775/3247

NH

NH

O

Rx-ID: 21592424 View in Reaxys 776/3247

NH

Br

O

N

O

Rx-ID: 24347407 View in Reaxys 777/3247

N

N

Br

O

O

Rx-ID: 25969194 View in Reaxys 778/3247

N

O

Rx-ID: 29630077 View in Reaxys 779/3247 O

NH

N

Rx-ID: 31808245 View in Reaxys 780/3247 O NH

Cl N O

Rx-ID: 31808326 View in Reaxys 781/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

93/428

2016-08-04 14:49:45


O

NH N

Br

O

Rx-ID: 36406799 View in Reaxys 782/3247 O NH

Cl

N

O

Rx-ID: 36406800 View in Reaxys 783/3247

NH

N

Cl O

O

Rx-ID: 36406801 View in Reaxys 784/3247

O

NH

O

N N

O O

N

Rx-ID: 1818801 View in Reaxys 785/3247 O N

N

NH N O

O

O

Rx-ID: 2433807 View in Reaxys 786/3247

NH N O O

Rx-ID: 5602751 View in Reaxys 787/3247 O

NH

N

N O

O

O

Rx-ID: 20167889 View in Reaxys 788/3247

N

N

NH N

O

O O

Rx-ID: 20168429 View in Reaxys 789/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

94/428

2016-08-04 14:49:45


N N

N

N

N

Cl

O

O

Rx-ID: 1808039 View in Reaxys 790/3247 N N NH

N

O

N H

Rx-ID: 32983602 View in Reaxys 791/3247 N N NH

N

O

H 2N

N H

Rx-ID: 32983606 View in Reaxys 792/3247 N

N

N

N

N

N

N

O

O

N H

N H

Rx-ID: 32983632 View in Reaxys 793/3247 N N

NH O

N

O

N O

N H

Rx-ID: 32983646 View in Reaxys 794/3247 N N

O

N

NH

HN N

N O O

Rx-ID: 8906460 View in Reaxys 795/3247

O NH

O

O

O

N

O

O

Rx-ID: 1703381 View in Reaxys 796/3247

NH

N

Br

OH

O

OH

O

Rx-ID: 3327268 View in Reaxys 797/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

95/428

2016-08-04 14:49:45


O

O

O

N N

O O

Rx-ID: 3508031 View in Reaxys 798/3247 O N

O

NH

O

O

O

Rx-ID: 3523162 View in Reaxys 799/3247

O

O NH

NH

Cl

N

O

NH

NH

O O

O

O

O

Rx-ID: 4923617 View in Reaxys 800/3247

O N

O

Rx-ID: 6593655 View in Reaxys 801/3247 O

O

N

N

O

N

Rx-ID: 9422566 View in Reaxys 802/3247 N

O

N

O

O N

O O

O

Rx-ID: 14131639 View in Reaxys 803/3247 O

F

N

O N O

O

Rx-ID: 14132844 View in Reaxys 804/3247

N

O N

O

O N

O O

O

Rx-ID: 14144450 View in Reaxys 805/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

96/428

2016-08-04 14:49:45


O NH

N

2,4-Cl2C6H3CH2X O

O

Rx-ID: 16555127 View in Reaxys 806/3247 O NH

N

O

O

Rx-ID: 18977515 View in Reaxys 807/3247

NH

N

I

O

O

OH

Rx-ID: 19838562 View in Reaxys 808/3247 O NH

O

O

O

N O

O

Rx-ID: 27990469 View in Reaxys 809/3247 O O

N

N

O

O

N

Rx-ID: 32449543 View in Reaxys 810/3247 O NH

O

O

N

Rx-ID: 32449548 View in Reaxys 811/3247 O O

NH

N

O

O

HN

Rx-ID: 33590134 View in Reaxys 812/3247 O

NH HO

O HN

Rx-ID: 33590252 View in Reaxys 813/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

97/428

2016-08-04 14:49:45


O

OH

N

N

O

O

Rx-ID: 37062060 View in Reaxys 814/3247 O NH

N

O

Rx-ID: 37062106 View in Reaxys 815/3247

NH

NH F

O

F

Sn

NH

O Tl

O

O

F

O

F

O F

O

F

Rx-ID: 2316591 View in Reaxys 816/3247

NH

O

Rx-ID: 6592470 View in Reaxys 817/3247

N

N

N O

O

Rx-ID: 9687602 View in Reaxys 818/3247

(7-methoxy-3,4-benzo-1,3-cycloheptadienyl)methoxymethylene chromium pentacarbonyl complex

N

O

Rx-ID: 13514386 View in Reaxys 819/3247

I

N

N O

O

Rx-ID: 13537265 View in Reaxys 820/3247

NH

I

N

O O

Rx-ID: 30088249 View in Reaxys 821/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

98/428

2016-08-04 14:49:45


NH N

Br

O O

Rx-ID: 31479362 View in Reaxys 822/3247 O

NH

N

Rx-ID: 31808244 View in Reaxys 823/3247 O NH

Cl N O

Rx-ID: 31808327 View in Reaxys 824/3247 O

N

Rx-ID: 32140493 View in Reaxys 825/3247

NH

N

O

Rx-ID: 32945874 View in Reaxys 826/3247

NH N

n-butyl halide O

O

Rx-ID: 32945940 View in Reaxys 827/3247

NH

O

O

NH

N

O

OH O

O

Rx-ID: 35858037 View in Reaxys 828/3247

NH

butyl halide

N

O O

Rx-ID: 36255899 View in Reaxys 829/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

99/428

2016-08-04 14:49:45


O NH

N

Br O

Rx-ID: 37739185 View in Reaxys 830/3247

NH O

N H

O

Rx-ID: 5599058 View in Reaxys 831/3247

N

N

NH 2

N

N

N

OH

O N

OH

O O

Rx-ID: 9602989 View in Reaxys 832/3247 O

H 2N

N

O

Rx-ID: 23722036 View in Reaxys 833/3247 O

O

NH

O

N

O

HN

HN

HN

Rx-ID: 29861619 View in Reaxys 834/3247

N

NH

N

N H

O O

O

Rx-ID: 77651 View in Reaxys 835/3247

N NH N

N

N

N

O

O

Rx-ID: 1560397 View in Reaxys 836/3247

N

N

NH

N

N N O

N O

Rx-ID: 4925549 View in Reaxys 837/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

100/428

2016-08-04 14:49:45


NH N O

Rx-ID: 5597390 View in Reaxys 838/3247

O

N N

Rx-ID: 7737064 View in Reaxys 839/3247

N

NH

N

N

N

O

O

Rx-ID: 10491757 View in Reaxys 840/3247

N N O

Rx-ID: 24238291 View in Reaxys 841/3247 O

O O

H 2N

NH

N

N

O

Rx-ID: 28970422 View in Reaxys 842/3247 NH 2 NH

N

O O

Rx-ID: 37943335 View in Reaxys 843/3247 N

NH 2

N

N

O

O

Rx-ID: 37943347 View in Reaxys 844/3247

NH

O

O

NH

O

O O

Rx-ID: 140154 View in Reaxys 845/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

101/428

2016-08-04 14:49:45


OH

NH

O

NH

O

O

O

O

Rx-ID: 157283 View in Reaxys 846/3247

NH

NH O

F

HO

F

O

Tl

O

O

F

O

F

O

O

O

F

F

Rx-ID: 1587042 View in Reaxys 847/3247 OH NH

O

Cl

O

N

K+

O– O

O

Rx-ID: 1647299 View in Reaxys 848/3247

OH O

O

N

O

N

O

O

Rx-ID: 1798957 View in Reaxys 849/3247 O

O O

NH

OH

NH

O

O

Rx-ID: 2223846 View in Reaxys 850/3247 O N

O

N

NH

O

OH

O

H N

O

OH

O

O

OH

Rx-ID: 3121531 View in Reaxys 851/3247

O

N

N

O

OH O

O

O

Rx-ID: 4432458 View in Reaxys 852/3247

NH

O

O

O

Rx-ID: 5825318 View in Reaxys 853/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

102/428

2016-08-04 14:49:45


O O

NH

Cl

O

N

O O

O

Rx-ID: 8803683 View in Reaxys 854/3247

O

NH

O

NH

N

O O

O O

Rx-ID: 9941759 View in Reaxys 855/3247

NH

NH

N O

O O

O

O

O

Rx-ID: 10496602 View in Reaxys 856/3247

NH

NH

N

O

O

O

O

O

O

Rx-ID: 10525560 View in Reaxys 857/3247 OH NH

O

N

O

O

Rx-ID: 16696825 View in Reaxys 858/3247

OH

N

O

N

O

O O

Rx-ID: 17836343 View in Reaxys 859/3247 OH

NH

<(η-chlorobenzene)(ηCp)Fe><PF6>

O

N

O

Rx-ID: 19527038 View in Reaxys 860/3247 O O

OH

NH

Cl O

N

O

O

Rx-ID: 21938083 View in Reaxys 861/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

103/428

2016-08-04 14:49:45


O NH

OH

NH O O

O

Rx-ID: 21939022 View in Reaxys 862/3247 O

O

OH

NH

HO O

N

O

O

Rx-ID: 21941061 View in Reaxys 863/3247 O

O

O

OH

NH

O N

O

O

O

Rx-ID: 21945119 View in Reaxys 864/3247

O

O

O

O

O OH

NH

O O

Rx-ID: 21952771 View in Reaxys 865/3247 OH O

N

O

Rx-ID: 23167422 View in Reaxys 866/3247 O NH

O

O

Rx-ID: 24077549 View in Reaxys 867/3247

NH

NH

aqueous (aq.) NaOAc O

J-methyl 3-formylindole-4-carboxylate O

O

O

O

Rx-ID: 24213858 View in Reaxys 868/3247

NH

NH

O

O O

O

O

Rx-ID: 24361026 View in Reaxys 869/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

104/428

2016-08-04 14:49:45


NH

O

NH

O

O

O

O

Rx-ID: 24516160 View in Reaxys 870/3247

NH

NH Cl

O

N

Cl

O O

O

O

O

Rx-ID: 25265320 View in Reaxys 871/3247

NH

NH

O Cl

P O

O

O

O

O

O

Rx-ID: 25529853 View in Reaxys 872/3247

NH

NH

N O O

O

O

O

O

Rx-ID: 27860291 View in Reaxys 873/3247

O

O

N

NH

O

O O

NH

O

Rx-ID: 29868995 View in Reaxys 874/3247

NH

NH HN

O

O

O

O

O

Rx-ID: 31402606 View in Reaxys 875/3247 O

O NH

O

HN

NH

O

O

Rx-ID: 31402607 View in Reaxys 876/3247

NH

NH HN

O

O

O

O

O

Rx-ID: 31402613 View in Reaxys 877/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

105/428

2016-08-04 14:49:45


NH

NH

HO

O O

O

O

Rx-ID: 34379791 View in Reaxys 878/3247 O

OH O

N

N

O O

O

Rx-ID: 36406977 View in Reaxys 879/3247

O

NH N

O

Cl

O O

Rx-ID: 1703394 View in Reaxys 880/3247

N

N

N

O O O

Rx-ID: 1834566 View in Reaxys 881/3247

N

N

Cl

HO

O

O

O

Rx-ID: 2430877 View in Reaxys 882/3247

O

O N

I

N

O

O

Rx-ID: 3896850 View in Reaxys 883/3247 O

NH O

Cl

N

O O

Rx-ID: 4067494 View in Reaxys 884/3247

O

N

O

N

O N

O

Rx-ID: 4178981 View in Reaxys 885/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

106/428

2016-08-04 14:49:45


NH

NH

N

O O

O

O

Rx-ID: 4269129 View in Reaxys 886/3247

N

N

N O

O

O

O

Rx-ID: 4719866 View in Reaxys 887/3247

OH

N

N

O

N

O

O

Rx-ID: 5060888 View in Reaxys 888/3247

N HO O

Rx-ID: 6594666 View in Reaxys 889/3247

N HO O

Rx-ID: 6596605 View in Reaxys 890/3247

N O O

Rx-ID: 6596607 View in Reaxys 891/3247

NH O O

Rx-ID: 6656910 View in Reaxys 892/3247

N

OH

O

Rx-ID: 6658409 View in Reaxys 893/3247

O

NH N O

Br

O O

Rx-ID: 8742261 View in Reaxys 894/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

107/428

2016-08-04 14:49:45


OH NH

HO

N

Br

O

O

Rx-ID: 8742269 View in Reaxys 895/3247

O

O

N

O

NH

NH

O

Rx-ID: 9263325 View in Reaxys 896/3247

O

O

N

O

NH

NH

O

Rx-ID: 9263327 View in Reaxys 897/3247

N

N

N

O O

O

O

Rx-ID: 9450564 View in Reaxys 898/3247

NH

N

I

O

O O

O

Rx-ID: 9869578 View in Reaxys 899/3247

NH O

O

I O

O N

Rx-ID: 10552862 View in Reaxys 900/3247

O

NH N O

Cl

O O

Rx-ID: 11207453 View in Reaxys 901/3247

NH

N

N

I O

O

O

O

Rx-ID: 11220118 View in Reaxys 902/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

108/428

2016-08-04 14:49:45


O

O

NH

N

OH

Rx-ID: 11767920 View in Reaxys 903/3247

NH

O

O

O

N

Rx-ID: 11770373 View in Reaxys 904/3247

OH

O

NH

NH

O

Rx-ID: 12909710 View in Reaxys 905/3247

OH O

NH

NH

O

Rx-ID: 12909712 View in Reaxys 906/3247

N

NH O

O

O

Rx-ID: 13946163 View in Reaxys 907/3247

O N

OH

O

NH

2-nitro-m-cresol; 6-nitro-m-cresol

O O

Rx-ID: 18009567 View in Reaxys 908/3247 O O

NH

N O

O

O

Rx-ID: 18028622 View in Reaxys 909/3247

O

NH

N

O

O

Rx-ID: 19395790 View in Reaxys 910/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

109/428

2016-08-04 14:49:45


O NH

N

red phosphorus

O

Rx-ID: 20545519 View in Reaxys 911/3247 O

N

O

Rx-ID: 23817948 View in Reaxys 912/3247

O

N

N

N

O

O O

Rx-ID: 25832049 View in Reaxys 913/3247 O

NH Br

N

O

O O

Rx-ID: 28970294 View in Reaxys 914/3247

NH

N

I O

O O

O

Rx-ID: 29415471 View in Reaxys 915/3247 O

NH N

OH

Rx-ID: 31808246 View in Reaxys 916/3247 O NH

HO

Cl

N

OH

O

Rx-ID: 31808332 View in Reaxys 917/3247

O

NH

O

N

S O

O

O

O O

O

Rx-ID: 32682192 View in Reaxys 918/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

110/428

2016-08-04 14:49:45


O

O

O

O

NH

N

S O

O

O

O

Rx-ID: 32682198 View in Reaxys 919/3247

N

NH O

O O

Rx-ID: 33439664 View in Reaxys 920/3247

N

N

N

N

O

O

O

Rx-ID: 33439701 View in Reaxys 921/3247

O

NH

N

O

Rx-ID: 34489315 View in Reaxys 922/3247 OH NH

HO

N

Cl

O

O

Rx-ID: 35736753 View in Reaxys 923/3247 OH

NH

N

O

Rx-ID: 35736761 View in Reaxys 924/3247

NH

N S

O

O

O

O

Rx-ID: 37094253 View in Reaxys 925/3247

NH

N

DES

O

O O

O

Rx-ID: 37250112 View in Reaxys 926/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

111/428

2016-08-04 14:49:45


O

NH

N

O

O O

HN

Rx-ID: 37314727 View in Reaxys 927/3247 O

H 2N

O

O

HN

Rx-ID: 37314740 View in Reaxys 928/3247

O

O

H N

O

O HN

O

O

Rx-ID: 37314756 View in Reaxys 929/3247 O

H N

O

O

O

O

HN

Rx-ID: 37314769 View in Reaxys 930/3247 OH

N

N

O

O

Rx-ID: 38777397 View in Reaxys 931/3247 OH NH

N

O

O

Rx-ID: 39200954 View in Reaxys 932/3247 O HN

O

N

O

O

NH

Rx-ID: 39599306 View in Reaxys 933/3247

NH O

NH

N N O

O

O

N O

O

Rx-ID: 1808379 View in Reaxys 934/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

112/428

2016-08-04 14:49:45


NH

O

N

O

O

Rx-ID: 6599384 View in Reaxys 935/3247 O

N

O NH

O

Rx-ID: 6659368 View in Reaxys 936/3247

NH

O

N

O

O

Rx-ID: 6659375 View in Reaxys 937/3247

N

O

N

O

O

Rx-ID: 6660205 View in Reaxys 938/3247

N O

N O

O

Rx-ID: 6660207 View in Reaxys 939/3247 O O

N

N

O

Rx-ID: 6660208 View in Reaxys 940/3247

NH O

N O

O

Rx-ID: 6660209 View in Reaxys 941/3247

NH O

N O

O

Rx-ID: 6660211 View in Reaxys 942/3247

NH O

N

NH

Vilsmeier-reagent

O

O

N O

O

Rx-ID: 6660212 View in Reaxys 943/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

113/428

2016-08-04 14:49:45


O O

N

NH

O

Rx-ID: 6660215 View in Reaxys 944/3247 O

NH

O

N

O N

O

O

NH

Rx-ID: 24126629 View in Reaxys 945/3247 O O

O

N

NH

(E)-3-(6-Dimethyl-1-methylindol-3-yl)-1-(3,4,5-trimethoxyphenyl)-2-propen-1-one O

O

N

N

O

Rx-ID: 24286216 View in Reaxys 946/3247 O O

O

N

NH

O

N O NH

Rx-ID: 24430665 View in Reaxys 947/3247 O

O

NH

O

N

N

O

N

O

O

NH

Rx-ID: 29858996 View in Reaxys 948/3247

NH O

O

N

O S

O

N O

O

O

O

N O

O

Rx-ID: 32682214 View in Reaxys 949/3247

N S

O

N

O

O

N O

N O

O

Rx-ID: 36422508 View in Reaxys 950/3247

NH O

N

S

N O

O

O

N O

O

Rx-ID: 37094245 View in Reaxys 951/3247

NH O

DM S

N O

O

N O

N O

O

Rx-ID: 37250117 View in Reaxys 952/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

114/428

2016-08-04 14:49:45


N

N O

N

N

O

N O

N O

O

Rx-ID: 38902988 View in Reaxys 953/3247

N

N

O

O O

N

O

O

NH 2

O

Rx-ID: 4744292 View in Reaxys 954/3247

NH

N

O

O O

NH 2

O

Rx-ID: 17197025 View in Reaxys 955/3247

N

N

O

O O

NH 2

O

Rx-ID: 17197766 View in Reaxys 956/3247

N O

N

SnH 4

N

O

O

(v4)

O

N

O

N

O

O

NH 2

O

Rx-ID: 25454835 View in Reaxys 957/3247

N

NH

O

O

NH 2

O

Rx-ID: 35686762 View in Reaxys 958/3247 Cl

Cl NH

NH

NH

NH

N

O

N

N

N

N

Cl

O

N

Cl

O

O

Rx-ID: 3936239 View in Reaxys 959/3247 Cl

Cl NH

Cl

NH

NH N

O

NH

N

N

N

N

O

N

Cl

O

O

O

Rx-ID: 3936240 View in Reaxys 960/3247 Cl

Cl NH

NH

NH N

O

NH

N

N

N

N Cl

N

O

O

Cl

O

O

Rx-ID: 3936241 View in Reaxys 961/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

115/428

2016-08-04 14:49:45


NH

NH –O

Na +

O

O I

O

O

O

Rx-ID: 2271818 View in Reaxys 962/3247

NH

NH

N

O O

O

O

O O

Rx-ID: 4269130 View in Reaxys 963/3247

NH

NH

N

O

HO

HO

O

O

O

Rx-ID: 4269131 View in Reaxys 964/3247 O NH O O

Rx-ID: 6596337 View in Reaxys 965/3247 O

O O

O

NH

N

NH

O

O

Rx-ID: 8672509 View in Reaxys 966/3247 O

O

NH

NH

N

O

O

O

O

Rx-ID: 8829261 View in Reaxys 967/3247 O

O

N

N

N

O O

O

O

Rx-ID: 9263284 View in Reaxys 968/3247

O

O

NH

N

NH

O

O

O O

Rx-ID: 9734351 View in Reaxys 969/3247

NH

NH

N

O O

O

O O

O

Rx-ID: 9735609 View in Reaxys 970/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

116/428

2016-08-04 14:49:45


O

O

O NH

N

NH

NH

O

O

O

O

O

O

Rx-ID: 9941948 View in Reaxys 971/3247 O

O

N

N

N

O

N

O

OH

O

Rx-ID: 11206736 View in Reaxys 972/3247

O

O

O

NH O O

O

Rx-ID: 12958631 View in Reaxys 973/3247 O O

N

O

O

NH

O N

O

O

O

O

Rx-ID: 12960327 View in Reaxys 974/3247 O

O NH

O N O

O

O

O

Rx-ID: 12960493 View in Reaxys 975/3247

O

NH

O

O

O

OH

O

NH

O

Rx-ID: 13383745 View in Reaxys 976/3247 O

O

O

NH

polymer-PPh2 (1+)-CH2-Ph*Br(1-)

O

O O

Rx-ID: 13390693 View in Reaxys 977/3247

NH

OH O

O O

NH O O

O

Rx-ID: 13390917 View in Reaxys 978/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

117/428

2016-08-04 14:49:45


O

NH

O

O

O

O

O

NH

O

Rx-ID: 13390939 View in Reaxys 979/3247

NH O

O

O

O

O

O

Rx-ID: 13398929 View in Reaxys 980/3247

O

NH

NH

O

O

O O

O

O

Rx-ID: 13404919 View in Reaxys 981/3247 O Z

O N

N

N

O

O

O

O

NH

O

Rx-ID: 13405181 View in Reaxys 982/3247

O

N

N

N

NH

Z

O

O

O

O

O

O

Rx-ID: 13405295 View in Reaxys 983/3247 O

OH

N

N

O

O

O

Rx-ID: 14359121 View in Reaxys 984/3247 O O

N

O N O

E

O

N

O

Rx-ID: 14361604 View in Reaxys 985/3247 O O

N

O

O

O

6-bromo-homoveratrate of sodium

NH

O O

O

Rx-ID: 14957166 View in Reaxys 986/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

118/428

2016-08-04 14:49:45


O

O

O

NH

O O

O

O

Rx-ID: 14959936 View in Reaxys 987/3247 O

O HO

O O

N

NH

O

O

O

Rx-ID: 14961428 View in Reaxys 988/3247 O

O

O

N

O

O

O

O

NH

O

O

Rx-ID: 14961443 View in Reaxys 989/3247 O O O

N

O

N

E

O

O

NH

O

O

O

Rx-ID: 14962638 View in Reaxys 990/3247 O

HO

O

NH

iron (II)-chloride

O

O

O

Rx-ID: 14966175 View in Reaxys 991/3247 O

O O

N

O

O

NH

O

O

O

Rx-ID: 15386174 View in Reaxys 992/3247 O

O N

O

N

O

O NH

O

E O

O

O

Rx-ID: 15398937 View in Reaxys 993/3247

O N O

OH

NH

2-nitro-m-cresol; 6-nitro-m-cresol

HO

O O

Rx-ID: 18009571 View in Reaxys 994/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

119/428

2016-08-04 14:49:45


O N

NH

OH

2-nitro-m-cresol; 6-nitro-m-cresol

O

O

O O

Rx-ID: 18009572 View in Reaxys 995/3247 O O

NH

N

HO

OH

O

O O

Rx-ID: 18020386 View in Reaxys 996/3247 O O

NH

N

O

O

O

O O

Rx-ID: 18028924 View in Reaxys 997/3247

NH

NH

O

O

O

O

Rx-ID: 18771710 View in Reaxys 998/3247

NH

NH O

O

O

O

O

Rx-ID: 18772577 View in Reaxys 999/3247

O

O

NH

O

NH

O O

Rx-ID: 23410602 View in Reaxys 1000/3247 O

O

OH

N

HO

OH

O NH

O

Rx-ID: 35858030 View in Reaxys 1001/3247 O NH

O

N

O

O

Rx-ID: 38315020 View in Reaxys 1002/3247 O NH

O

O

N O

Rx-ID: 38315024 View in Reaxys 1003/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

120/428

2016-08-04 14:49:45


O

O

O N

N

O

N O

O

Rx-ID: 38315032 View in Reaxys 1004/3247 O NH

OH

O

O

O

NH

OH

Rx-ID: 39599351 View in Reaxys 1005/3247 O NH

O

O O

O

NH

OH

Rx-ID: 39599366 View in Reaxys 1006/3247 O NH

OH

O

O

NH

OH

Rx-ID: 39599383 View in Reaxys 1007/3247 O

O NH

O

O

N

O NH

O

OH

Rx-ID: 39599390 View in Reaxys 1008/3247 O NH I

F

F

N O

Rx-ID: 27907593 View in Reaxys 1009/3247 O F N

Rx-ID: 32140371 View in Reaxys 1010/3247

S

NH

N

S

Cl

O

O

Rx-ID: 8742260 View in Reaxys 1011/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

121/428

2016-08-04 14:49:45


O N

N

S

O

S N

Rx-ID: 39257847 View in Reaxys 1012/3247 O

O

N

NH

NH

NH

O OH

O

OH

N O

O

OH

O

Rx-ID: 4734574 View in Reaxys 1013/3247 O O

N

O

O N

O

O

N

NH

O

N

OH N

O

O

O

Rx-ID: 9683698 View in Reaxys 1014/3247 OH

O

N

N O

O

N O

N O

O

O

Rx-ID: 9688116 View in Reaxys 1015/3247

O

O O

N

O

O

OH

N

N

N O

O

Rx-ID: 9691685 View in Reaxys 1016/3247 O O

N

O

OH N

O

OH

N

N

O

Rx-ID: 13617463 View in Reaxys 1017/3247 OH

O

N

N O

O

N

N

O

O

O

Rx-ID: 13629300 View in Reaxys 1018/3247

O

O O

N

O

O

N

OH N

N O

Rx-ID: 13630678 View in Reaxys 1019/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

122/428

2016-08-04 14:49:45


O

O

N

NH

NH

O

OH

O

Rx-ID: 17240149 View in Reaxys 1020/3247

NH

NH

O O

N O

OH

O

Rx-ID: 17240150 View in Reaxys 1021/3247 O O

O

O

N

N

O

OH

N

N

O

O

Rx-ID: 28628850 View in Reaxys 1022/3247

NH

O

NH S

S

O

O

Rx-ID: 4727263 View in Reaxys 1023/3247

O

NH

NH

S

O O

Rx-ID: 17196043 View in Reaxys 1024/3247

O

NH

NH

S

S O

Rx-ID: 17197729 View in Reaxys 1025/3247

O

NH

NH

S

S O

Rx-ID: 17204311 View in Reaxys 1026/3247

OH

NH

Cl

NH

O

O

O

O

Rx-ID: 4419983 View in Reaxys 1027/3247

O

NH Cl O

Rx-ID: 6593447 View in Reaxys 1028/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

123/428

2016-08-04 14:49:45


NH

Cl

NH

O

O

O

O

Rx-ID: 17835545 View in Reaxys 1029/3247

Cl

NH

O

NH

O

O

O

O

Rx-ID: 17839074 View in Reaxys 1030/3247 Cl NH

N

Cl

Cl

O

O

Rx-ID: 5258183 View in Reaxys 1031/3247

N Cl

O

Rx-ID: 5596389 View in Reaxys 1032/3247

NH

N Cl

ethyl-halide

Cl

O

O

Rx-ID: 5596390 View in Reaxys 1033/3247 Cl NH

N

Br

Cl

O

O

Rx-ID: 8866076 View in Reaxys 1034/3247

N

N O

N

O

Cl

O

Rx-ID: 9734103 View in Reaxys 1035/3247

N Cl

N Cl

O

O

Rx-ID: 13387141 View in Reaxys 1036/3247

N HN

Cl

O

Rx-ID: 13391576 View in Reaxys 1037/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

124/428

2016-08-04 14:49:45


Cl

Cl

N

N

O

O

Rx-ID: 15268540 View in Reaxys 1038/3247 Cl

Cl

N

N

O

O

Rx-ID: 15268546 View in Reaxys 1039/3247 N N

Cl

N

N N

O O

Rx-ID: 15276625 View in Reaxys 1040/3247 N

N

N

Cl

N N

O O

Rx-ID: 15277770 View in Reaxys 1041/3247 O Cl

NH HO

HN

Rx-ID: 24210426 View in Reaxys 1042/3247 O

N O

Cl N

Rx-ID: 24593769 View in Reaxys 1043/3247 O N

N

N

Cl N

Cl

Rx-ID: 33439643 View in Reaxys 1044/3247 O

NH Cl

Cl N

Rx-ID: 33439706 View in Reaxys 1045/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

125/428

2016-08-04 14:49:45


O

NH

O

O

N Cl

S

Cl

O

O

O

Rx-ID: 39868650 View in Reaxys 1046/3247

Cl

NH

O O

Rx-ID: 6591908 View in Reaxys 1047/3247

NH Cl HO O

Rx-ID: 6593978 View in Reaxys 1048/3247 O Cl

N

O

Rx-ID: 6595130 View in Reaxys 1049/3247

NH Cl O O

Rx-ID: 6656820 View in Reaxys 1050/3247

NH

NH

N

O

Cl

O HO

HO

O

Rx-ID: 9085520 View in Reaxys 1051/3247 O

O N

N

O

O

Cl N O

Rx-ID: 10496259 View in Reaxys 1052/3247 O

O

Cl

Cl N

N

N

N

O

OH

Rx-ID: 11206735 View in Reaxys 1053/3247

NH

NH

O O

Cl HO O

Rx-ID: 14730041 View in Reaxys 1054/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

126/428

2016-08-04 14:49:45


Cl N

O

NH

O

O

O

NH

Cl

Rx-ID: 42105563 View in Reaxys 1055/3247

O

O

O

N

N

O

O

O NH

Cl

Rx-ID: 42105629 View in Reaxys 1056/3247

O

O

O

N

N

O

O

O NH

Cl

Cl

Rx-ID: 42105634 View in Reaxys 1057/3247 O O

N

O

O

O

NH

Cl

Cl

Rx-ID: 42105638 View in Reaxys 1058/3247

O

O

Cl

O

NH

Cl

NH 2

Rx-ID: 42105642 View in Reaxys 1059/3247

O

O

H N

Cl

O

O

NH

Cl O

Rx-ID: 42105645 View in Reaxys 1060/3247 O

O

Cl

N

F

Cl

F

O

O

NH

F

Rx-ID: 42105648 View in Reaxys 1061/3247

O

NH

O O O

O

O

Rx-ID: 24239506 View in Reaxys 1062/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

127/428

2016-08-04 14:49:45


NH

NH

NH

NH

N N

E

N I

Z

O

O

O N

Rx-ID: 3342005 View in Reaxys 1063/3247

NH

NH

N

O

Z

O

Rx-ID: 20942310 View in Reaxys 1064/3247

NH NH O

E O N

Rx-ID: 20942311 View in Reaxys 1065/3247 O

O

HN

N

F

F

O

O F

F

NH

Rx-ID: 42105479 View in Reaxys 1066/3247

NH

N

Cl

O

O

Rx-ID: 1647225 View in Reaxys 1067/3247

NH NH

O O

Rx-ID: 19484577 View in Reaxys 1068/3247 N

NH

N N O O

Rx-ID: 104566 View in Reaxys 1069/3247 N NH

NH

N

O O

N

Rx-ID: 3344975 View in Reaxys 1070/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

128/428

2016-08-04 14:49:45


N NH

N

Br

N

O

O

Rx-ID: 4417425 View in Reaxys 1071/3247 N

N

O

Rx-ID: 5464622 View in Reaxys 1072/3247

O

O

NH

N

N

O N

Rx-ID: 20060466 View in Reaxys 1073/3247

O

O

NH

N

N

N

O

Rx-ID: 20060513 View in Reaxys 1074/3247

O

O

NH

N

N N

O

Rx-ID: 20068446 View in Reaxys 1075/3247 N NH

Cl

N

N O

O

Rx-ID: 37739187 View in Reaxys 1076/3247 F

F F

N

F

F NH

O

F NH

O

Rx-ID: 4357925 View in Reaxys 1077/3247 F F

F NH

O

Rx-ID: 6659357 View in Reaxys 1078/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

129/428

2016-08-04 14:49:45


F

F F

F

F

F NH

O

NH

O

O

Rx-ID: 17939264 View in Reaxys 1079/3247 F

F F

F

F

F NH

O

NH

OH

O

Rx-ID: 17946298 View in Reaxys 1080/3247

NH

F

F

Cl

O

Cl

Cl

F

HN

F

F

F

Cl

O

Rx-ID: 25191845 View in Reaxys 1081/3247 F

F

F

F

F

F

O

S O

O

NH

O O Br

HN

O

Rx-ID: 28300539 View in Reaxys 1082/3247

NH

NH N

O

F

F F

F

F

F

O

Rx-ID: 36699726 View in Reaxys 1083/3247

F Cl F

N F

HN

F F

F

O

Rx-ID: 40194418 View in Reaxys 1084/3247

NH NH O

F F

NH

O O

Tl

O

O

F

E F

O

O

F

F

O

O

Rx-ID: 2890808 View in Reaxys 1085/3247 O O

NH Br

N

O O

Rx-ID: 42527497 View in Reaxys 1086/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

130/428

2016-08-04 14:49:45


NH N

Br O

O

Rx-ID: 1647337 View in Reaxys 1087/3247

NH

NH

N

O

O

Rx-ID: 3343884 View in Reaxys 1088/3247

N

NH

O

NH

O

Rx-ID: 5214066 View in Reaxys 1089/3247

NH

O

Rx-ID: 5861987 View in Reaxys 1090/3247

N

N

N

O

O

Rx-ID: 9146448 View in Reaxys 1091/3247

NH O

O

Rx-ID: 20786985 View in Reaxys 1092/3247

NH HN H 2N

O

Rx-ID: 20820170 View in Reaxys 1093/3247

NH N

O O

Rx-ID: 28896281 View in Reaxys 1094/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

131/428

2016-08-04 14:49:45


NH

NH

N

O O

Rx-ID: 30030931 View in Reaxys 1095/3247

NH

NH

O

Rx-ID: 30444250 View in Reaxys 1096/3247

NH

NH

N

O

O

Rx-ID: 30444288 View in Reaxys 1097/3247

NH

O

Rx-ID: 30444294 View in Reaxys 1098/3247

NH

NH

Cl

O

Rx-ID: 30444309 View in Reaxys 1099/3247

NH

B

O

Rx-ID: 30444323 View in Reaxys 1100/3247

NH

Br

N

O O

Rx-ID: 33576223 View in Reaxys 1101/3247

O

NH N

O

O

O O

Rx-ID: 35681134 View in Reaxys 1102/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

132/428

2016-08-04 14:49:45


O

O NH

S N

O

O O

Rx-ID: 36051692 View in Reaxys 1103/3247

O

O NH

S

N

O

O O

Rx-ID: 36051698 View in Reaxys 1104/3247

NH

N

Br

O O

Rx-ID: 36051702 View in Reaxys 1105/3247 HO

N

N

O

O

Rx-ID: 37062057 View in Reaxys 1106/3247

O

N

N

P I

O

O

Rx-ID: 37062076 View in Reaxys 1107/3247

NH N

O O

Rx-ID: 37062102 View in Reaxys 1108/3247

NH N

O

Rx-ID: 37062115 View in Reaxys 1109/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

133/428

2016-08-04 14:49:45


NH

NH

Cl

Cl O

Cl

O

Rx-ID: 4245208 View in Reaxys 1110/3247

Cl

Cl

NH

NH

O

Cl

O

Rx-ID: 4247131 View in Reaxys 1111/3247

NH Cl

Cl

O

Rx-ID: 6592423 View in Reaxys 1112/3247

Cl

NH Cl

O

Rx-ID: 6593475 View in Reaxys 1113/3247 O N

NH

O

Cl

Cl

E

Cl O

N

Rx-ID: 9689546 View in Reaxys 1114/3247 O Cl

N

Cl

O

NH Cl

E O

N

Rx-ID: 9689798 View in Reaxys 1115/3247

Cl

Cl

NH N

O

NH Cl

O

O

Rx-ID: 27768979 View in Reaxys 1116/3247 O Cl N

NH

Cl

O

Cl

Cl

NH

Rx-ID: 29525048 View in Reaxys 1117/3247 O

Cl

HN Cl

Rx-ID: 32140381 View in Reaxys 1118/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

134/428

2016-08-04 14:49:45


Cl

Cl

O

NH

NH

O Cl

Cl

O

O

Rx-ID: 42063790 View in Reaxys 1119/3247 O

Cl

Cl

NH

OH NH

Cl

O

Cl

O

Rx-ID: 42063945 View in Reaxys 1120/3247 Cl

Cl

Cl

NH 2

NH

Cl

O

Rx-ID: 42064065 View in Reaxys 1121/3247

O

E

N

H N

Cl

Cl

NH

O

Cl

Cl

O

Rx-ID: 42064149 View in Reaxys 1122/3247

Cl

Cl

O

NH

NH

O Cl

Cl

O

Rx-ID: 42064182 View in Reaxys 1123/3247 N

N

O

O

N

O

NH

NH

O

Rx-ID: 9973086 View in Reaxys 1124/3247 N

OH O

NH

NH

O

Rx-ID: 12909701 View in Reaxys 1125/3247

N

N Cl

N N

O

O

N

Rx-ID: 4169396 View in Reaxys 1126/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

135/428

2016-08-04 14:49:45


Cl

N

N

N

N

N

O

O

Rx-ID: 8903057 View in Reaxys 1127/3247 N

N

N

NH

N

O

O

Rx-ID: 15253529 View in Reaxys 1128/3247 Cl

N

N

N

N

N

O

O

Rx-ID: 15268541 View in Reaxys 1129/3247 Cl

N

N

N

N

N

O

O

Rx-ID: 15268547 View in Reaxys 1130/3247 N N

N

N

N

N

N N

O O

Rx-ID: 15276626 View in Reaxys 1131/3247 N

N

N

N

N

N

N N

O O

Rx-ID: 15277771 View in Reaxys 1132/3247 O

H N

NH

NH

N

N

O

O

O

O

Rx-ID: 1457928 View in Reaxys 1133/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

136/428

2016-08-04 14:49:45


N

N

N

NH

N

N

N H O

O

O

Rx-ID: 8907604 View in Reaxys 1134/3247

N

HO

N O

Cl

O

O

Rx-ID: 1602023 View in Reaxys 1135/3247

NH

NH

N

O O

O

O

Rx-ID: 3342557 View in Reaxys 1136/3247

O

O NH

O

NH

N

O

NH

NH

Cl O

O

O

O

Rx-ID: 4923630 View in Reaxys 1137/3247

O

O

N

Sn

N

Cl

O

O

Rx-ID: 8945670 View in Reaxys 1138/3247 O

O

N

N

O

N

Rx-ID: 9423073 View in Reaxys 1139/3247

NH N

Br O O

O

O

Rx-ID: 10191195 View in Reaxys 1140/3247 O

O

N

N O F

O

Rx-ID: 14124621 View in Reaxys 1141/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

137/428

2016-08-04 14:49:45


O N

O

O

N

N

O

O

O

Rx-ID: 14142779 View in Reaxys 1142/3247 O O

O

N

N

N O

O

O

Rx-ID: 14146050 View in Reaxys 1143/3247

O

NH N

Cl

O O

Rx-ID: 15058087 View in Reaxys 1144/3247

NH N

Cl

O O O

Rx-ID: 18641209 View in Reaxys 1145/3247

HO

O

N

N

O O

Rx-ID: 37062050 View in Reaxys 1146/3247

O NH N

O

O

Rx-ID: 37062093 View in Reaxys 1147/3247

O

NH

N

O

Rx-ID: 37062105 View in Reaxys 1148/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

138/428

2016-08-04 14:49:45


N

NH N

O

Rx-ID: 5824573 View in Reaxys 1149/3247 H N

S

HN

NH S

I

N

N

S

H N

N

O

Rx-ID: 5280265 View in Reaxys 1150/3247

N

N

O

N

O

Rx-ID: 3342444 View in Reaxys 1151/3247

N

O NH

NH

O

Rx-ID: 3343647 View in Reaxys 1152/3247

NH N

O

Rx-ID: 21816167 View in Reaxys 1153/3247

N

Br

O

Rx-ID: 21819343 View in Reaxys 1154/3247

NH 2

NH

O

Rx-ID: 21824060 View in Reaxys 1155/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

139/428

2016-08-04 14:49:45


NH

Cl O

NH 2 O

Rx-ID: 21841847 View in Reaxys 1156/3247 O

NH N

Rx-ID: 32945878 View in Reaxys 1157/3247 O

NH N

isoamyl halide O

Rx-ID: 32945938 View in Reaxys 1158/3247 O

NH N

3-methylbutyl halide O

Rx-ID: 36255898 View in Reaxys 1159/3247 O

NH

Br

N

O

Rx-ID: 36406797 View in Reaxys 1160/3247

NH

pentyl halide

N

O O

Rx-ID: 37218982 View in Reaxys 1161/3247

NH

O

Br

N O

Rx-ID: 37739175 View in Reaxys 1162/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

140/428

2016-08-04 14:49:45


O

NH Br

N O

Rx-ID: 37739176 View in Reaxys 1163/3247

O NH

N

Br

O

Rx-ID: 37739178 View in Reaxys 1164/3247 O

O N

N

Rx-ID: 38895598 View in Reaxys 1165/3247 O NH

N

O

N

N Cl O

O

Rx-ID: 1647429 View in Reaxys 1166/3247

NH

N

I NH

O

N

O

O

O

Rx-ID: 5132844 View in Reaxys 1167/3247

NH

O

HN O

Rx-ID: 5606573 View in Reaxys 1168/3247 O NH 2

N

O

Rx-ID: 6660331 View in Reaxys 1169/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

141/428

2016-08-04 14:49:45


O NH

O

NH 2

N

Cl NH 2

O

O

Rx-ID: 25266719 View in Reaxys 1170/3247 O HN HN

N

O

O

HN HN

O

Rx-ID: 29868997 View in Reaxys 1171/3247 NH 2

O

O

NH

O S

N

O

N

O

Cl

O

Rx-ID: 33590202 View in Reaxys 1172/3247

O

Br

NH

NH 2 N

O O

Rx-ID: 33590318 View in Reaxys 1173/3247

O

HN

NH 2 N

O

O

Rx-ID: 33590431 View in Reaxys 1174/3247 O

NH HN

H 2N

HN

O

Rx-ID: 34887903 View in Reaxys 1175/3247 O O

N

O

N

N HN

N

HN

Rx-ID: 38902991 View in Reaxys 1176/3247

H 2N

O

H N

NH O

NH

Rx-ID: 39599313 View in Reaxys 1177/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

142/428

2016-08-04 14:49:45


O

O

H N

N

N

O

O O

NH

NH

Rx-ID: 39599321 View in Reaxys 1178/3247 F

F

O

F

F

N

NH

F

F

O

F

F

Rx-ID: 2663683 View in Reaxys 1179/3247

F

O

F

F

F

NH

N F

F

O

F

F

Rx-ID: 2670396 View in Reaxys 1180/3247 F

F F

F

NH

N

NH

O

F

F F

F

O

Rx-ID: 3342479 View in Reaxys 1181/3247 F F

NH

F O

F

Rx-ID: 6605644 View in Reaxys 1182/3247 F

F F

F

NH

F

NH

F F

O

F

Rx-ID: 21236256 View in Reaxys 1183/3247 F

F

F

F

NH

F O

F F

F

O

F

Rx-ID: 21266628 View in Reaxys 1184/3247

F

F F

F

NH

N F

F F

F

O

Rx-ID: 21266838 View in Reaxys 1185/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

143/428

2016-08-04 14:49:45


F N

F

F

F

F

F

F

NH

O

F

F

Rx-ID: 21267146 View in Reaxys 1186/3247 F NE

F

F

F

F

F

F

NH

O

F

F

Rx-ID: 21468676 View in Reaxys 1187/3247

O NH

O

O

O

N

O

O

O

O

Rx-ID: 139386 View in Reaxys 1188/3247

NH

O

O

NH N

O

O O

Rx-ID: 146895 View in Reaxys 1189/3247

NH

O

O

NH

N O

O

O O

Rx-ID: 146906 View in Reaxys 1190/3247

NH

O

O

NH

O

O O

Rx-ID: 146914 View in Reaxys 1191/3247

NH

O O

NH

O O

N

O

Rx-ID: 343133 View in Reaxys 1192/3247 O O

NH

Cl

O

N

O O O

Rx-ID: 1703397 View in Reaxys 1193/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

144/428

2016-08-04 14:49:45


O NH

O

O

O

N

O

O

O

O

Rx-ID: 1751852 View in Reaxys 1194/3247 O NH

O

Cl

O

NH

O

NH

NH

O

O

O

Cl

O

O

O O

O

Rx-ID: 1798398 View in Reaxys 1195/3247 O NH

O

Cl

O

NH

O

O

Cl

O

N

O O

O

Rx-ID: 1798399 View in Reaxys 1196/3247

O

N

O

NH

I

O

O O

O

Rx-ID: 1952104 View in Reaxys 1197/3247 O O

O

OH

NH

O

O

NH

O

O

Rx-ID: 2378459 View in Reaxys 1198/3247 O

O N

O

O

NH

O O

O

O

Rx-ID: 2933190 View in Reaxys 1199/3247

OH O O

N

O

N

O

O

Rx-ID: 3259365 View in Reaxys 1200/3247

N

O

N

OH

O O

O

O

Rx-ID: 3663766 View in Reaxys 1201/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

145/428

2016-08-04 14:49:45


NH

O

O

NH

N

O O

O O

Rx-ID: 4419963 View in Reaxys 1202/3247 O

O

O

NH

O

NH

O O

O

O

Rx-ID: 4891188 View in Reaxys 1203/3247

O

NH

O O

Rx-ID: 5478748 View in Reaxys 1204/3247

NH

O H

O

O

O

H

O

NH

OH

urotropin

N

O O

Rx-ID: 5478749 View in Reaxys 1205/3247

N

O

O

O

Rx-ID: 5606229 View in Reaxys 1206/3247 O O

NH

O

Rx-ID: 5606402 View in Reaxys 1207/3247 O

NH

O

Br

O

N

O

O O

Rx-ID: 8742264 View in Reaxys 1208/3247

NH

O

O

NH

N O

O

O O

Rx-ID: 9606150 View in Reaxys 1209/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

146/428

2016-08-04 14:49:45


O

NH

Cl

O

O

N

O

O O

Rx-ID: 9867224 View in Reaxys 1210/3247

NH

N

I O

O

O

O

O

O

Rx-ID: 10525683 View in Reaxys 1211/3247 O

O

NH

O

I

O

N O

O

Rx-ID: 10552131 View in Reaxys 1212/3247

O

N

O

NH

O

O O

Rx-ID: 13001353 View in Reaxys 1213/3247 O O

Br O

NH

N

O O

Rx-ID: 13604001 View in Reaxys 1214/3247

O

NH

O

O

O

Rx-ID: 13612349 View in Reaxys 1215/3247 O

O

N

O O

NH

E

O

O O

Rx-ID: 13615700 View in Reaxys 1216/3247 O

N

O

NH

Z

O

O

N

O

N

Rx-ID: 13621126 View in Reaxys 1217/3247 O

O

O

NH

N

O

O

Rx-ID: 16867784 View in Reaxys 1218/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

147/428

2016-08-04 14:49:45


O

NH

N

O

O OH

O O

Rx-ID: 18606137 View in Reaxys 1219/3247 O OH

NH

O

NH

OH

O

Rx-ID: 19443908 View in Reaxys 1220/3247 OH NH

O

N

O

Rx-ID: 19527134 View in Reaxys 1221/3247 OH NH

O

N

O O

Rx-ID: 19527938 View in Reaxys 1222/3247

NH

O

NH

O

O

OH

O

Rx-ID: 22282909 View in Reaxys 1223/3247 O

OH

N O

Rx-ID: 23077599 View in Reaxys 1224/3247 O

N O O

Rx-ID: 25540047 View in Reaxys 1225/3247

O NH

O

O O

Cl

N O O

Rx-ID: 28472374 View in Reaxys 1226/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

148/428

2016-08-04 14:49:45


N

N

N O

O O

O

O

O

Rx-ID: 28933982 View in Reaxys 1227/3247 O

NH

O

Cl

O

N

O

O O

Rx-ID: 28999350 View in Reaxys 1228/3247

NH

O O

NH O

O N

O

O

O

Rx-ID: 35034252 View in Reaxys 1229/3247 O

O

O O

HO

NH

O

NH

O O

O

Rx-ID: 37929291 View in Reaxys 1230/3247

O

N

O

N

NH 2

HN

O

O

O

Rx-ID: 4560818 View in Reaxys 1231/3247 O F

NH

N

F

Rx-ID: 31808294 View in Reaxys 1232/3247 O F

NH

Cl N

F O

Rx-ID: 31808470 View in Reaxys 1233/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

149/428

2016-08-04 14:49:45


F

NH

F

N

Br

O

O

Rx-ID: 36051701 View in Reaxys 1234/3247

N

HO

N

Cl

O

O

O

Rx-ID: 2430909 View in Reaxys 1235/3247

O

NH N

O

Cl

O O

Rx-ID: 2856873 View in Reaxys 1236/3247 -1 F (v4)

F

B FF

N

N O

N+

O

O

Rx-ID: 3104872 View in Reaxys 1237/3247

N

N

N

O O

O

O

Rx-ID: 3343653 View in Reaxys 1238/3247

N

O

O

N

O N

O

Rx-ID: 4178983 View in Reaxys 1239/3247

N O O

Rx-ID: 6597409 View in Reaxys 1240/3247

N O O

Rx-ID: 6657454 View in Reaxys 1241/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

150/428

2016-08-04 14:49:45


N HO O

Rx-ID: 6659075 View in Reaxys 1242/3247

N O O

Rx-ID: 6659076 View in Reaxys 1243/3247

N

OH

O

Rx-ID: 6659078 View in Reaxys 1244/3247

N

OH

O

Rx-ID: 6659079 View in Reaxys 1245/3247

NH

Br

N

O

O

O

O

Rx-ID: 9869579 View in Reaxys 1246/3247

O

N

O

O

NH

NH

O

Rx-ID: 10058043 View in Reaxys 1247/3247

OH NH

O NH

O

Rx-ID: 12732513 View in Reaxys 1248/3247

O

O

NH

NH

O

Rx-ID: 12732906 View in Reaxys 1249/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

151/428

2016-08-04 14:49:45


N

N

O

O

N

O

Rx-ID: 20287966 View in Reaxys 1250/3247

O NH

N

O

Rx-ID: 20545862 View in Reaxys 1251/3247

NH

N

O

O O

Rx-ID: 21816718 View in Reaxys 1252/3247 HO

N

O

Rx-ID: 23725807 View in Reaxys 1253/3247

O

N O

Rx-ID: 23817951 View in Reaxys 1254/3247

O

O

O NH

S O N

O O

O

Rx-ID: 23839122 View in Reaxys 1255/3247

O

NH

O

Br N

O O

Rx-ID: 28970376 View in Reaxys 1256/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

152/428

2016-08-04 14:49:45


O

N

O

Rx-ID: 29338383 View in Reaxys 1257/3247

O

I

NH

O

N

O

O

Rx-ID: 32643667 View in Reaxys 1258/3247 HO NH

N

OH

Cl

O

O

Rx-ID: 35736752 View in Reaxys 1259/3247 HO

NH

N

O

Rx-ID: 35736759 View in Reaxys 1260/3247

HO

O

NH

N

E

Si N

O

O

O

Rx-ID: 35858046 View in Reaxys 1261/3247 O

NH

N

O

O O

HN

Rx-ID: 37314729 View in Reaxys 1262/3247 O NH

N

O

O O

HN

Rx-ID: 37314731 View in Reaxys 1263/3247 O

H 2N

O

O

HN

Rx-ID: 37314741 View in Reaxys 1264/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

153/428

2016-08-04 14:49:45


O

H 2N

O

O

HN

Rx-ID: 37314742 View in Reaxys 1265/3247

O

O

NH O

O

O HN

O

Rx-ID: 37314758 View in Reaxys 1266/3247 O O

O

NH

O

O

HN

O

Rx-ID: 37314761 View in Reaxys 1267/3247 O

H N

O

O

O

O

HN

Rx-ID: 37314770 View in Reaxys 1268/3247 O

H N

O

O

O

O

HN

Rx-ID: 37314771 View in Reaxys 1269/3247 O O

O

N

O

NH

NH

Rx-ID: 39599308 View in Reaxys 1270/3247 O O

O

N

O

NH

NH

Rx-ID: 39599310 View in Reaxys 1271/3247

NH Cl

N

propargyl-halide

Cl

O

O

Rx-ID: 8485399 View in Reaxys 1272/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

154/428

2016-08-04 14:49:45


NH O

N

I

O

N O

O

N O

O

Rx-ID: 3885103 View in Reaxys 1273/3247

N O

N O

O

Rx-ID: 6662742 View in Reaxys 1274/3247 O O

N

N

O

Rx-ID: 6662743 View in Reaxys 1275/3247

NH O

N O

N

N

O

O

O

Rx-ID: 21026995 View in Reaxys 1276/3247 O H 2N

O

O

N

O

O

O NH

H 2N

HN

Rx-ID: 23047538 View in Reaxys 1277/3247 O N

N

O

O

O

O

N N

N O

Rx-ID: 29986074 View in Reaxys 1278/3247 O O

NH

O S

O

O

O

O

O

N

N

N

O

O

Rx-ID: 32682199 View in Reaxys 1279/3247 O NH O

O

O

N

S

N O

N

O

Rx-ID: 37094246 View in Reaxys 1280/3247 O NH O

DES

N O

O

O

N N

O

Rx-ID: 37250116 View in Reaxys 1281/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

155/428

2016-08-04 14:49:45


N

N

O

O O

N

O

O

NH 2

O

Rx-ID: 4744514 View in Reaxys 1282/3247

N

NH O

O

NH 2

O

Rx-ID: 13946164 View in Reaxys 1283/3247

N

N O

O

NH 2

O

Rx-ID: 13946945 View in Reaxys 1284/3247

N

N

O

O O

NH 2

O

Rx-ID: 13947313 View in Reaxys 1285/3247

NH

N

O

O O

NH 2

O

Rx-ID: 35686795 View in Reaxys 1286/3247

OH

NH

O

O O

Rx-ID: 5606685 View in Reaxys 1287/3247 O O

NH

O

O

N

NH

NH

O

O

O

O

O

Rx-ID: 3343921 View in Reaxys 1288/3247

H

N

O

N

E O

N

O

O

O racemate

Rx-ID: 3658686 View in Reaxys 1289/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

156/428

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N O

N O

O O OH

O

Rx-ID: 4099452 View in Reaxys 1290/3247

NH

NH

N

O

O

O

O

O

O

Rx-ID: 4269132 View in Reaxys 1291/3247 O

OH

O

O

O

N N

O O

Rx-ID: 4961150 View in Reaxys 1292/3247 O

O O

O

N

N

N

O

O

Rx-ID: 5214037 View in Reaxys 1293/3247 O

O

O N

N

N

N

O O

O

O O

O

Rx-ID: 9973077 View in Reaxys 1294/3247 O

O

O

NH

I N

O

O

O

Rx-ID: 10552896 View in Reaxys 1295/3247

OH

O

O

O

O

O

N

N

Rx-ID: 11274477 View in Reaxys 1296/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

157/428

2016-08-04 14:49:45


O

O

O

NH N O

O

Rx-ID: 11770395 View in Reaxys 1297/3247 O

O

N

NH

O

O

O

Rx-ID: 12955188 View in Reaxys 1298/3247

O

O

O

N O O

O

Rx-ID: 12958590 View in Reaxys 1299/3247 O O

N

O

O

N

O N

O

O

O

O

Rx-ID: 12960303 View in Reaxys 1300/3247 O

O N

O N O

O

O

O

Rx-ID: 12960468 View in Reaxys 1301/3247 O

O O

O

NH

N

O

Rx-ID: 16211986 View in Reaxys 1302/3247 O E

O O

N

O

N

O

O

N

O

O

O

Rx-ID: 16218568 View in Reaxys 1303/3247 OH

NH

O N O

O

Rx-ID: 16778276 View in Reaxys 1304/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

158/428

2016-08-04 14:49:45


O N

NH

OH

2-nitro-m-cresol; 6-nitro-m-cresol

O

O

O O

Rx-ID: 18009573 View in Reaxys 1305/3247 O O

NH

N O

O

O

O O

Rx-ID: 18029493 View in Reaxys 1306/3247

NH

O O

O

N

O O OH

O

Rx-ID: 18114385 View in Reaxys 1307/3247

N O

N O O OH

O

Rx-ID: 18120644 View in Reaxys 1308/3247

N OH

O

N

O O OH

O

Rx-ID: 18121979 View in Reaxys 1309/3247

N

O O

O

N

O O OH

O

Rx-ID: 18123892 View in Reaxys 1310/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

159/428

2016-08-04 14:49:45


N S O

O

N

S

O

O OH

O

Rx-ID: 18124596 View in Reaxys 1311/3247 OH

O N

O

Rx-ID: 23725802 View in Reaxys 1312/3247

O

N

O

N

N

O

O

O

O

Rx-ID: 30182369 View in Reaxys 1313/3247 O

O

OH

N HO

OH

O NH

O

Rx-ID: 35858031 View in Reaxys 1314/3247 O F N

Rx-ID: 32140374 View in Reaxys 1315/3247

N O

N

N Cl

O

Rx-ID: 5116669 View in Reaxys 1316/3247

NH Cl

allyl-halide

N Cl

O

O

Rx-ID: 8485387 View in Reaxys 1317/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

160/428

2016-08-04 14:49:45


Z

E

N

N

N

Cl

Cl

Cl

O

O

O

Rx-ID: 10345026 View in Reaxys 1318/3247

NH O

N Cl

N O

Rx-ID: 16429755 View in Reaxys 1319/3247

NH

N

O

Cl Cl

O

Rx-ID: 16448253 View in Reaxys 1320/3247

NH

Br

N

Cl

Cl O

O

Rx-ID: 28783490 View in Reaxys 1321/3247

NH

NH O

O O

O

N

O

O

Rx-ID: 1751860 View in Reaxys 1322/3247 O

N

O NH

O O

Rx-ID: 6661538 View in Reaxys 1323/3247 O

N

O

O

N

O

O N

O

N

O N

O

Rx-ID: 9204744 View in Reaxys 1324/3247 O

O

N

N

O

O

N O

N O

N O

O

Rx-ID: 9670624 View in Reaxys 1325/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

161/428

2016-08-04 14:49:45


O

NH

O

O

N

N

O

Rx-ID: 14425217 View in Reaxys 1326/3247 O

O O

N

NH

O

N

O

N

O

Rx-ID: 14427088 View in Reaxys 1327/3247 O O

O

OH

N

N

O

O

N

N

O

Rx-ID: 14446050 View in Reaxys 1328/3247 O NH

F

N O

Br

F O

O

Rx-ID: 27730120 View in Reaxys 1329/3247 O F

NH

N

F

OH

Rx-ID: 31808295 View in Reaxys 1330/3247 O F

NH

HO

Cl N

F

OH

O

Rx-ID: 31808477 View in Reaxys 1331/3247

O

NH

OH

NH HO

O

O

Rx-ID: 1796098 View in Reaxys 1332/3247

NH

Sn

F F

NH NH

O O

Tl

O

O

F

F

O F

O O

F

Rx-ID: 2195548 View in Reaxys 1333/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

162/428

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O O

O

NH

O

N

Cl

Cl

O

O

Rx-ID: 2390816 View in Reaxys 1334/3247

O N Cl

O

Rx-ID: 6596158 View in Reaxys 1335/3247

N Cl

O

O

Rx-ID: 6597714 View in Reaxys 1336/3247 Cl O

NH

O

Rx-ID: 6597814 View in Reaxys 1337/3247 O N Cl

O

Rx-ID: 6658922 View in Reaxys 1338/3247 O NH

Cl

Cl

N

O

O

O

Cl

Rx-ID: 28761200 View in Reaxys 1339/3247 Cl NH

Cl

Br

N

O

O

Rx-ID: 1647362 View in Reaxys 1340/3247

N Cl

O

Rx-ID: 5596410 View in Reaxys 1341/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

163/428

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N Cl

O

Rx-ID: 5599260 View in Reaxys 1342/3247 Cl

Cl

N

N

O

O

Rx-ID: 15268545 View in Reaxys 1343/3247 Cl

Cl

N

N

O

O

Rx-ID: 15272009 View in Reaxys 1344/3247 N

N

N

Cl

N

N

O

O

Rx-ID: 15276088 View in Reaxys 1345/3247 N

N

N

Cl

N N

O O

Rx-ID: 15277769 View in Reaxys 1346/3247 O Cl I

N

Rx-ID: 23836775 View in Reaxys 1347/3247 O

N Cl

Rx-ID: 32140372 View in Reaxys 1348/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

164/428

2016-08-04 14:49:45


F

F NH

O F

NH

O–

N

(v2)

F

Tl3+ – O O– (v3) (v2)

F

(v2)

O O

NH Sn

F

O O

O

F

N

F F

Rx-ID: 1647290 View in Reaxys 1349/3247

NH N

O

F Sn

O

F

NH NH

Tl

O

O

F

O

F

O

NH

O

O

N

F

F

Rx-ID: 2411698 View in Reaxys 1350/3247

N

NH

NH

NH

NH

Br

N

Sn

O

O

O

O

Rx-ID: 28628839 View in Reaxys 1351/3247

NH

N

NH

NH

NH

Sn

Br

N O

O

O

O

Rx-ID: 28628841 View in Reaxys 1352/3247

O

N

N

N

Cl

O

HN

N O

Rx-ID: 29753150 View in Reaxys 1353/3247 O S

O S

O

N

O

N

O

OH

Rx-ID: 4110006 View in Reaxys 1354/3247 O S

NH

O S Cl

O

N

O

O O

Rx-ID: 8742265 View in Reaxys 1355/3247 O

NH SH

HO

O S

O

NH

O

Rx-ID: 11152438 View in Reaxys 1356/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

165/428

2016-08-04 14:49:45


O

O O

S

N

O

N

HO HO

O

Rx-ID: 18055511 View in Reaxys 1357/3247 O

NH

S

O

N

O S

O

O O

Rx-ID: 18060458 View in Reaxys 1358/3247 O S

H 2N HO

O

N

HO O

Rx-ID: 18090793 View in Reaxys 1359/3247 O

O S

S

O

O

N

N

O

Rx-ID: 18090851 View in Reaxys 1360/3247 O S

O

O

N

S

O

N

O S

O

O

O

Rx-ID: 18091138 View in Reaxys 1361/3247

O

S O

O S

O

O O

N

S

O

O

N

O

O O

Rx-ID: 18091216 View in Reaxys 1362/3247 O S

O S O

O O

S O

O

N

O

O S O

N O

O S

O

Rx-ID: 18091278 View in Reaxys 1363/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

166/428

2016-08-04 14:49:45


O

O

O O

O NH

O

S

S

NH

O

S O

NH

O

Rx-ID: 28766547 View in Reaxys 1364/3247 O

NH SH

S

Na +

S

S NH

O

Rx-ID: 11152436 View in Reaxys 1365/3247

O

NH

OH

NH

O

O Cl

Cl

O

O

Rx-ID: 332571 View in Reaxys 1366/3247

NH

O

OH

NH

O

O Cl

Cl

O

Rx-ID: 22218164 View in Reaxys 1367/3247 O O

NH

O

Cl

Cl

HO O

O

HN

Rx-ID: 22974252 View in Reaxys 1368/3247 Cl

O

O OH

HN

Rx-ID: 38162362 View in Reaxys 1369/3247

O

Cl

NH

O

Cl

HN

HO O

O

Rx-ID: 41104809 View in Reaxys 1370/3247

Cl

O

O

NH

Cl

HN

HO

O O

O

Rx-ID: 41104826 View in Reaxys 1371/3247

O

NH Cl

O

N Cl

Cl O

O

Rx-ID: 2858493 View in Reaxys 1372/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

167/428

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NH Cl O O

Rx-ID: 6596593 View in Reaxys 1373/3247

N Cl O O

Rx-ID: 6659643 View in Reaxys 1374/3247

NH

NH

O

N

Cl

O O

O

O

Rx-ID: 9085484 View in Reaxys 1375/3247

NH

NH

N Br

O

Br

O

Rx-ID: 75228 View in Reaxys 1376/3247

NH

OH

NH

O

Br EN

Br O

Rx-ID: 386368 View in Reaxys 1377/3247

Br

Br

NH N

NH

O

O

Rx-ID: 1642064 View in Reaxys 1378/3247

NH

NH N

O

Br

Br

O

Rx-ID: 1642447 View in Reaxys 1379/3247

NH

NH

O

Br

O

Rx-ID: 1647457 View in Reaxys 1380/3247

NH

Br

NH

Br

O

Rx-ID: 1650444 View in Reaxys 1381/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

168/428

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Br

Br

NH

NH

N

O

O

Rx-ID: 4243789 View in Reaxys 1382/3247

Si Br

Br

NH

N

O O

Rx-ID: 4641600 View in Reaxys 1383/3247

NH

NH

N

O

Br

O

O

Rx-ID: 4666984 View in Reaxys 1384/3247

NH

NH

N

O Br

Br

O

Rx-ID: 4718483 View in Reaxys 1385/3247

Br

NH

NH

NH

Br O

O

O

Rx-ID: 5316198 View in Reaxys 1386/3247

NH Br O

Rx-ID: 5426534 View in Reaxys 1387/3247

Br

NH

O

Rx-ID: 6653310 View in Reaxys 1388/3247

NH

NH Br

N

Br

O

O

Rx-ID: 8633931 View in Reaxys 1389/3247

O

NH

O N

Br O

Br O

Rx-ID: 10549982 View in Reaxys 1390/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

169/428

2016-08-04 14:49:45


Br

Br

NH

O N O

O

Rx-ID: 13819466 View in Reaxys 1391/3247

NH

NH

Br

MeX

O

Rx-ID: 15799080 View in Reaxys 1392/3247

Br

Br

NH

NH

O

Rx-ID: 17370041 View in Reaxys 1393/3247

Br

Si Br

NH

N

O

Rx-ID: 17391893 View in Reaxys 1394/3247

Si Br

Br

NH

N

O

Br

Rx-ID: 17392698 View in Reaxys 1395/3247

NH

NH

O

O

Br

O

Rx-ID: 20168349 View in Reaxys 1396/3247 O

O

NH

N

Br

O

Br

Rx-ID: 20199851 View in Reaxys 1397/3247

NH

Br

O

NH

O

Br

O

Rx-ID: 20199856 View in Reaxys 1398/3247

NH Br

NH

O O

Br O

Rx-ID: 22175409 View in Reaxys 1399/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

170/428

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NH

O

NH

O

Br

Br O

O

Rx-ID: 22187176 View in Reaxys 1400/3247

O

N

H N

NH

O

Br

Br

O

Rx-ID: 22204409 View in Reaxys 1401/3247

NH

HN

Br Br

H 2N

O

Rx-ID: 22205050 View in Reaxys 1402/3247

NH

Cl

NH

O Cl

Br

Br O

Rx-ID: 23658930 View in Reaxys 1403/3247

NH

NH

Br

Br

O

Rx-ID: 24134177 View in Reaxys 1404/3247 OH

NH

NH

N

Br

O

O

O

Rx-ID: 28628836 View in Reaxys 1405/3247

Br

Br

NH N+

Cl

Cl

NH

O

Rx-ID: 30070537 View in Reaxys 1406/3247

NH

NH HN

Br

Br

O

Rx-ID: 31402597 View in Reaxys 1407/3247

Br O

N O

NH

Br

O

Rx-ID: 31857211 View in Reaxys 1408/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

171/428

2016-08-04 14:49:45


Br

Br

NH

N N

O

O

O

Rx-ID: 31857223 View in Reaxys 1409/3247 Br NH

N O

N

Br

O

O

Rx-ID: 31867850 View in Reaxys 1410/3247 O O

N

NH

Br

Br

O

Rx-ID: 31867933 View in Reaxys 1411/3247

NH

NH

Br O

Rx-ID: 32945875 View in Reaxys 1412/3247

O S

O

NH Na +

O–

NH

Br O

Rx-ID: 32945955 View in Reaxys 1413/3247

O S

NH

O + O– Na

N

Br O

O

Rx-ID: 32945965 View in Reaxys 1414/3247

Br

Br

NH

NH

HN

O

Rx-ID: 33111788 View in Reaxys 1415/3247

NH

NH

N

N

Br

Br

O

Rx-ID: 38903006 View in Reaxys 1416/3247

NH Br

Cl

O

O

Cl

NH Br O

Rx-ID: 40166092 View in Reaxys 1417/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

172/428

2016-08-04 14:49:45


NH

NH

Br

Br

N

O

Rx-ID: 40466739 View in Reaxys 1418/3247

NH

Br

NH

N

Br

O

Rx-ID: 40466740 View in Reaxys 1419/3247 Br

Br

NH

NH

N

O

Rx-ID: 40466741 View in Reaxys 1420/3247

NH

NH Cl

HNO3as

O

O

Cl N O

O

Rx-ID: 22853800 View in Reaxys 1421/3247

NH

NH Cl

O

O

Cl N O

O

Rx-ID: 24580780 View in Reaxys 1422/3247

N

O

N

N

F

O F

O

F

F O

Rx-ID: 29000181 View in Reaxys 1423/3247

O N

OH

NH

O

S

O S

O

O

O

OH

O

O

Rx-ID: 10166415 View in Reaxys 1424/3247 O O NH

S

OH

N

O

O

Rx-ID: 10188093 View in Reaxys 1425/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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O

O S

NH

NH

NH

HO

HO S O

O

O

O

O

Rx-ID: 10188094 View in Reaxys 1426/3247

OH

NH

NH

S

SH

O

O O

O

Rx-ID: 10232263 View in Reaxys 1427/3247

O

OH

NH

O

S

N

O

O

SH

O O

Rx-ID: 12389951 View in Reaxys 1428/3247

O

OH

NH

O

S

N

O

O

Cl

O O

Rx-ID: 12428218 View in Reaxys 1429/3247

O NH

Cl

N O

O

O

Rx-ID: 4417423 View in Reaxys 1430/3247

O NH

HO

N O

O

O

Rx-ID: 4859931 View in Reaxys 1431/3247

O HO

hex-5-yn-2-one and 2-prop-2-ynyl-pent-4-ynoic acid

N

O

O

Rx-ID: 17837004 View in Reaxys 1432/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

174/428

2016-08-04 14:49:45


E

O

O

N–

S O

E

Na +

N

O O

Rx-ID: 2178357 View in Reaxys 1433/3247 O NH Br

NH

O

Rx-ID: 31850224 View in Reaxys 1434/3247

N N

N

N Cl

N

O

O

Rx-ID: 5111201 View in Reaxys 1435/3247

NH

N

O

N

N N

N O

Rx-ID: 16429756 View in Reaxys 1436/3247

N

NH

N

N

O

N Cl

O

Rx-ID: 16448255 View in Reaxys 1437/3247

N

N

N

N

O

N

N

O

Rx-ID: 16449653 View in Reaxys 1438/3247 N

N

O

Rx-ID: 6602943 View in Reaxys 1439/3247

NH

N

O

F F

O

F

F F

NH

F

Rx-ID: 36699725 View in Reaxys 1440/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

175/428

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O

O

O

O N

N

O

OH

Rx-ID: 40525073 View in Reaxys 1441/3247 O O

O

NH

N

O

OH

O

Rx-ID: 40525083 View in Reaxys 1442/3247

O

NH

Cl N

O O O

Rx-ID: 1647226 View in Reaxys 1443/3247

NH

Br

N

O O

Rx-ID: 1647339 View in Reaxys 1444/3247

NH

NH

HO

B

O

F

E

F

OH

O

Tl

O

O

O

F

Z F

O F

F

Rx-ID: 2057542 View in Reaxys 1445/3247 O

NH

N

Br O

Rx-ID: 11197413 View in Reaxys 1446/3247

NH

NH

N

O O

Rx-ID: 30030915 View in Reaxys 1447/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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O O

O

NH

S

N

O

E

O

E

Rx-ID: 36051693 View in Reaxys 1448/3247 O

O

O S

NH

O N

Z O Z

Rx-ID: 36051694 View in Reaxys 1449/3247 O Cl

N

POCl3

O

Cl N

Cl

Rx-ID: 22853804 View in Reaxys 1450/3247 O Cl

N O

Cl N

Cl

Rx-ID: 24580783 View in Reaxys 1451/3247 Cl O

N O

N

Cl

Cl

Rx-ID: 24593768 View in Reaxys 1452/3247 O Cl

NH

O

Cl

O

Cl

S O

O

Cl

N

O

Rx-ID: 27768996 View in Reaxys 1453/3247

NH N

O

O

O

Rx-ID: 5616110 View in Reaxys 1454/3247 O O O

HN N

Rx-ID: 27739066 View in Reaxys 1455/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

177/428

2016-08-04 14:49:45


N

N O O

Rx-ID: 6601951 View in Reaxys 1456/3247

NH

N

O

NH

HN

O O

HN O

Rx-ID: 9204750 View in Reaxys 1457/3247

NH

O

NH

HN O

OH

O

Rx-ID: 14556899 View in Reaxys 1458/3247 N

Cl

N N

N N

O O

Rx-ID: 8897878 View in Reaxys 1459/3247 N N N

NH N

O O

Rx-ID: 15253531 View in Reaxys 1460/3247 N

Cl

N N

N

N

O

O

Rx-ID: 15268549 View in Reaxys 1461/3247 N N

Cl

N

N N

O O

Rx-ID: 15272011 View in Reaxys 1462/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

178/428

2016-08-04 14:49:45


N

N

N

N

N N

N N

O O

Rx-ID: 15276089 View in Reaxys 1463/3247

N

N

N

N

N N

N

N

O

O

Rx-ID: 15277773 View in Reaxys 1464/3247 O

H N

NH

NH

N

N

O

O

O

O

Rx-ID: 1481691 View in Reaxys 1465/3247 O N

E N

Rx-ID: 23353072 View in Reaxys 1466/3247

O

NH

F

O

O N

O

O O

Rx-ID: 1647270 View in Reaxys 1467/3247

NH

NH

NH

O O

E

O

E

O O

O

O

O

O

Rx-ID: 1647366 View in Reaxys 1468/3247 O

O E

O

NH

N

O

E

O

NH

O

Rx-ID: 2431679 View in Reaxys 1469/3247

NH

NH O

E

N

O

O

O

E O

O

Rx-ID: 3344980 View in Reaxys 1470/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

179/428

2016-08-04 14:49:45


O

O

O

O E

E

N

O NH

NH

O

Rx-ID: 3344981 View in Reaxys 1471/3247

NH O

F

O O

F

NH

Tl

O

O

F O

O F

O

E

O

F

O

F

Rx-ID: 3352909 View in Reaxys 1472/3247

O

NH

NH

E

Br

O

E

O

O

Sn O

O

Rx-ID: 3952252 View in Reaxys 1473/3247 O

NH

O

N E

O

O

O

O

Rx-ID: 11219576 View in Reaxys 1474/3247

O

O

O E

NH

NH

O

Rx-ID: 20048306 View in Reaxys 1475/3247 O

NH

O

E

O

NH

O

Rx-ID: 20048309 View in Reaxys 1476/3247

O

HO NH

O E NH

O

Rx-ID: 20048357 View in Reaxys 1477/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

180/428

2016-08-04 14:49:45


O

O E

O NH

O

N

O

O O

Rx-ID: 20053511 View in Reaxys 1478/3247

O

O

O

O E

NH

NH

O

Rx-ID: 20057727 View in Reaxys 1479/3247

O

NH

NH

E

Br

O

Sn

O

O

O

O

Rx-ID: 28628840 View in Reaxys 1480/3247

NH

NH NH

NH

OH I

O

O

O

O

HO

Rx-ID: 1795868 View in Reaxys 1481/3247

NH

NH NH

OH I

O

O

O

HO

Rx-ID: 1795869 View in Reaxys 1482/3247

NH O

F

HO

E

F

Sn

NH

Tl

O

O

O

F

E

O

F

O

HO F

F

Rx-ID: 2479288 View in Reaxys 1483/3247

O

O O

N N

O O

Rx-ID: 3509365 View in Reaxys 1484/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

181/428

2016-08-04 14:49:45


OH NH

NH

E

Br HO

E

O

Sn

O

Rx-ID: 3952254 View in Reaxys 1485/3247

NH

NH

N

O O

O

O

Rx-ID: 4269137 View in Reaxys 1486/3247 O NH

N

Cl O

O

O

Rx-ID: 9715186 View in Reaxys 1487/3247

O

NH

Cl

O

N

O O

Rx-ID: 10188077 View in Reaxys 1488/3247 O

N

C

O

N

O

O

Rx-ID: 11142728 View in Reaxys 1489/3247

O

O NH Br

N

O O

Rx-ID: 11197418 View in Reaxys 1490/3247 O O N

Br N

I

O O

Rx-ID: 11267415 View in Reaxys 1491/3247 O

NH

N

O

O

Rx-ID: 16569580 View in Reaxys 1492/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

182/428

2016-08-04 14:49:45


O N

NH

OH

2-nitro-m-cresol; 6-nitro-m-cresol

O

O O

Rx-ID: 18009576 View in Reaxys 1493/3247

O O

NH O

N

O

O

Rx-ID: 18029712 View in Reaxys 1494/3247

NH NH

O O

HO

Rx-ID: 19484578 View in Reaxys 1495/3247

O N O

Rx-ID: 23817964 View in Reaxys 1496/3247

OH

OH

NH Br

NH

E

Sn

O

O

Rx-ID: 28628832 View in Reaxys 1497/3247

O

O

N

N Cl

Sn

O

O

Rx-ID: 28846711 View in Reaxys 1498/3247 O

H N

O NH

N

O

N H

N

NH

NH

O

O

Rx-ID: 35858039 View in Reaxys 1499/3247

I

S

HN N

H N

NH S

S

N

H N

N

O

Rx-ID: 5277834 View in Reaxys 1500/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

183/428

2016-08-04 14:49:45


O

N

NH

hexyl halide O

Rx-ID: 37218981 View in Reaxys 1501/3247 O

N

NH

Br

O

Rx-ID: 38548933 View in Reaxys 1502/3247 O

O

N

N

Rx-ID: 38895593 View in Reaxys 1503/3247 O

O N

N

Rx-ID: 38895600 View in Reaxys 1504/3247

NH

O

N

O

N N

O

N H

Rx-ID: 32983622 View in Reaxys 1505/3247

O

O

N

O

O

N

N

N

N H

O

N H

Rx-ID: 32983635 View in Reaxys 1506/3247

O

O

N

H 2N

O

N

N H

N N H

Rx-ID: 32983638 View in Reaxys 1507/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

184/428

2016-08-04 14:49:45


O

N

N

N

O

N

O

O

N

N

N N H

N H

Rx-ID: 32983641 View in Reaxys 1508/3247 N

N F O

Rx-ID: 6605297 View in Reaxys 1509/3247 H 2N

O

N

O

Rx-ID: 6661851 View in Reaxys 1510/3247

O

NH

NH

NH – Li+

HN O

O O

O

Rx-ID: 8679762 View in Reaxys 1511/3247

NH

HN

NH

O

O

O O

Rx-ID: 15671501 View in Reaxys 1512/3247 O

NH

N O O

N

Rx-ID: 36406773 View in Reaxys 1513/3247 O

OH O

N

N H

N O

O

N

Rx-ID: 36406843 View in Reaxys 1514/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

185/428

2016-08-04 14:49:45


O

O

N

N

O

O O

N

Rx-ID: 36406978 View in Reaxys 1515/3247

O

N

Cl

HN

N S N

N S

Rx-ID: 28614122 View in Reaxys 1516/3247

N N

O

Rx-ID: 23725803 View in Reaxys 1517/3247 O NH

HN

NH

N

N OH

HO N

O

NH

N

NH

Rx-ID: 26009914 View in Reaxys 1518/3247 O NH

HN

NH

N HO

N

O

NH

N

Rx-ID: 26009915 View in Reaxys 1519/3247 O

NH N

Cl

N

O

N

Rx-ID: 29217475 View in Reaxys 1520/3247

N NH

N

Cl

N

Cl

H

O

O

Rx-ID: 34656646 View in Reaxys 1521/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

186/428

2016-08-04 14:49:45


O O

NH O O

Rx-ID: 5611290 View in Reaxys 1522/3247

NH

O

NH

O

O

O O

Rx-ID: 169526 View in Reaxys 1523/3247

O

NH

O

Br

O

N

O O O

Rx-ID: 1647341 View in Reaxys 1524/3247

O

N

O

N

N

O

O

O O

Rx-ID: 1843689 View in Reaxys 1525/3247 O NH

O

NH

N O

O

O

O

Rx-ID: 1861820 View in Reaxys 1526/3247

NH

O

E O

NH

O

O

O

O

Rx-ID: 3127017 View in Reaxys 1527/3247

NH O

NH O

E O

O

O

O

Rx-ID: 3127026 View in Reaxys 1528/3247 O O

O E

NH

O

NH

O

O

Rx-ID: 3127069 View in Reaxys 1529/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

187/428

2016-08-04 14:49:45


O NH

N

O

O

O

E

O

O

O

Rx-ID: 3137763 View in Reaxys 1530/3247 O NH

N O

O

E O

O

O

O

Rx-ID: 3138871 View in Reaxys 1531/3247

O

Br–

O O

N+

O

N

N

O

Rx-ID: 3178094 View in Reaxys 1532/3247 O O

NH

Cl

O

N

O O O

Rx-ID: 3355458 View in Reaxys 1533/3247

O

O

O N

N O

O

O

O

Rx-ID: 3508878 View in Reaxys 1534/3247

N

O

N

OH

O O

O

O

Rx-ID: 3665018 View in Reaxys 1535/3247

O

NH

5-methyl-indole-carboxylic acid-(2)-ethyl ester

O O

Rx-ID: 5451150 View in Reaxys 1536/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

188/428

2016-08-04 14:49:45


O

N

O O

Rx-ID: 5607956 View in Reaxys 1537/3247

N O

O

O

Rx-ID: 5614125 View in Reaxys 1538/3247

O

N

O O

Rx-ID: 5828806 View in Reaxys 1539/3247

O O

N

O

Rx-ID: 6603913 View in Reaxys 1540/3247 O

NH N

O O

O

O

Rx-ID: 16556038 View in Reaxys 1541/3247

O

NH

N

O

O OH

O O

Rx-ID: 18606138 View in Reaxys 1542/3247

O

NH

<(η-chlorobenzene)(ηCp)Fe><PF6>

O

N

O

Rx-ID: 19527036 View in Reaxys 1543/3247

NH

NH O

O

O

O

Rx-ID: 20045591 View in Reaxys 1544/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

189/428

2016-08-04 14:49:45


NH

NH O

O

O

O

Rx-ID: 20045592 View in Reaxys 1545/3247

NH

O N O

O

O

O

Rx-ID: 20048051 View in Reaxys 1546/3247 O

NH

O

NH

O

O

Rx-ID: 20048310 View in Reaxys 1547/3247 O

O E

O

NH

NH

O

O

Rx-ID: 20056682 View in Reaxys 1548/3247

O

NH O

N

O O

Rx-ID: 20126020 View in Reaxys 1549/3247

O

N

O

N

Z N

O

Rx-ID: 20159026 View in Reaxys 1550/3247 O O NH

N

O

Rx-ID: 21436662 View in Reaxys 1551/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

190/428

2016-08-04 14:49:45


O O

O

NH

Cl N

O

O

O

Rx-ID: 21938085 View in Reaxys 1552/3247 O

O

O

NH

HO O

N

O

O

Rx-ID: 21941063 View in Reaxys 1553/3247 O

O

O

O

NH

O O

N

O

O

Rx-ID: 21945121 View in Reaxys 1554/3247

O

O

O

O

O O

NH

O O

Rx-ID: 21952773 View in Reaxys 1555/3247

O NH

Cl

O

O

N O

O

O

Rx-ID: 23840990 View in Reaxys 1556/3247

NH

O

O

O

O

HN

O

Rx-ID: 24283205 View in Reaxys 1557/3247 O

O

N

N

O

O

O

N O

Rx-ID: 25832045 View in Reaxys 1558/3247 O

NH

O

N

O O

O

O

Rx-ID: 25936946 View in Reaxys 1559/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

191/428

2016-08-04 14:49:45


O

N

O

NH

O

OH

O

Rx-ID: 30723351 View in Reaxys 1560/3247

N

O

NH

methyl halide

O

O O

O

O

Rx-ID: 30723400 View in Reaxys 1561/3247

O

N

O

NH

I

O

O O

O

Rx-ID: 33683443 View in Reaxys 1562/3247 O

O O

O O

O

HO

NH

O

NH

O

Rx-ID: 37929232 View in Reaxys 1563/3247 O O

NH

O NH

Rx-ID: 37929262 View in Reaxys 1564/3247 O O

NH

O NH

O

Rx-ID: 37929282 View in Reaxys 1565/3247

NH

N

O

O O

O O

Rx-ID: 42234023 View in Reaxys 1566/3247

O

NH N

O

Cl

O O

Rx-ID: 2856865 View in Reaxys 1567/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

192/428

2016-08-04 14:49:45


O NH N

O

Cl

O O

Rx-ID: 2857697 View in Reaxys 1568/3247

N

N

O

N

OH

O

O

Rx-ID: 3740756 View in Reaxys 1569/3247

NH

NH

N

O O

O

O

Rx-ID: 4269134 View in Reaxys 1570/3247

N O O

Rx-ID: 6660448 View in Reaxys 1571/3247

N

OH

O

Rx-ID: 6660449 View in Reaxys 1572/3247

O N

OH

O

NH

2-nitro-m-cresol; 6-nitro-m-cresol

O O

Rx-ID: 18009574 View in Reaxys 1573/3247

O O

NH O

N

O

O

Rx-ID: 18029276 View in Reaxys 1574/3247

O NH

N

O

Rx-ID: 20545875 View in Reaxys 1575/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

193/428

2016-08-04 14:49:45


O NH

N

O

Rx-ID: 20545881 View in Reaxys 1576/3247

O

N O

Rx-ID: 23817945 View in Reaxys 1577/3247

O

N O

Rx-ID: 23817969 View in Reaxys 1578/3247

O

N O

Rx-ID: 23817972 View in Reaxys 1579/3247

O

N

O

Rx-ID: 29338795 View in Reaxys 1580/3247 O N

O O

O

HN

Rx-ID: 37314723 View in Reaxys 1581/3247 O NH

N

O

O

O

HN

Rx-ID: 37314733 View in Reaxys 1582/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

194/428

2016-08-04 14:49:45


O

H 2N

O

O

HN

Rx-ID: 37314743 View in Reaxys 1583/3247 O O

Cl O

HN

Rx-ID: 37314754 View in Reaxys 1584/3247 O O

O

NH

O

O

HN

O

Rx-ID: 37314764 View in Reaxys 1585/3247 O

H N

O

O

O

O

HN

Rx-ID: 37314772 View in Reaxys 1586/3247

O O

NH

O

Br

N

O

Rx-ID: 37739177 View in Reaxys 1587/3247 O

O

NH Br

N

O O

Rx-ID: 37739179 View in Reaxys 1588/3247 O O

O

N

O

NH

NH

Rx-ID: 39599312 View in Reaxys 1589/3247

Si

NH Cl

Si

N

O

O

Rx-ID: 1647433 View in Reaxys 1590/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

195/428

2016-08-04 14:49:45


N

N

N

O

Si

Si O

Rx-ID: 34199199 View in Reaxys 1591/3247

N

N Si

Br

O

Rx-ID: 34199205 View in Reaxys 1592/3247 O O

N

O

O

O

N

NH NH

O

Rx-ID: 24238297 View in Reaxys 1593/3247

NH O

N

I O

N O

N

O

O

O

Rx-ID: 2851960 View in Reaxys 1594/3247

NH

O

N

NH

O

O N

O

N

O O

Rx-ID: 4269141 View in Reaxys 1595/3247 O O

NH NH

O

Rx-ID: 5830327 View in Reaxys 1596/3247

NH O

N O

N

N

O

O

O

Rx-ID: 21026997 View in Reaxys 1597/3247 O

O OH N

O

O

Br

N

NH 2

O

NH 2

Rx-ID: 25592361 View in Reaxys 1598/3247 O O

N

O

N HN

O

N

HN

O

N

Rx-ID: 34138128 View in Reaxys 1599/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

196/428

2016-08-04 14:49:45


NH

NH

N

O

N

N

O

O

O

Rx-ID: 4269136 View in Reaxys 1600/3247

N O NH 2

O

Rx-ID: 5828838 View in Reaxys 1601/3247

O N

NH

OH

2-nitro-m-cresol; 6-nitro-m-cresol

O

N

O O

Rx-ID: 18009575 View in Reaxys 1602/3247

O O

NH

N N

N

O O

O

Rx-ID: 18029765 View in Reaxys 1603/3247

N

N

NH

O

HN

N

N

O O O

Rx-ID: 29216485 View in Reaxys 1604/3247 O

N

H N

HN

O

O

H N

HN

O

Rx-ID: 29868996 View in Reaxys 1605/3247 O

O N

OH

N

O

N

NH

O

Rx-ID: 35858033 View in Reaxys 1606/3247

OH

NH

O HO

O

O

Rx-ID: 5614868 View in Reaxys 1607/3247

NH

O

HO

O

O

NH

N

O O

HO O

Rx-ID: 2761665 View in Reaxys 1608/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

197/428

2016-08-04 14:49:45


O

O

NH

NH

N

O

O

O

O

O

O

Rx-ID: 3345853 View in Reaxys 1609/3247

O

NH

O

HO O

Rx-ID: 5828520 View in Reaxys 1610/3247 O O

NH

O

O

Rx-ID: 5832282 View in Reaxys 1611/3247

O

O

O

NH

N

O

NH

O O

O O

Rx-ID: 8949724 View in Reaxys 1612/3247 OH

NH O

O

N

Hal-CH2CO2H O

O

O

Rx-ID: 9443486 View in Reaxys 1613/3247

O

NH

O

NH

O O

Cl

O O

HO

Rx-ID: 9617360 View in Reaxys 1614/3247 O

O NH

NH

N

O O

O

O

O

Rx-ID: 9941947 View in Reaxys 1615/3247

O

O

O

NH O O

O

O

Rx-ID: 12958597 View in Reaxys 1616/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

198/428

2016-08-04 14:49:45


O O

N

O

O

NH

O

O

N O

O

O

O

Rx-ID: 12960310 View in Reaxys 1617/3247 O

O

NH

O N

O

O

O

O

O

Rx-ID: 12960475 View in Reaxys 1618/3247 O O

NH NH

O

O

O

Rx-ID: 18645159 View in Reaxys 1619/3247 O

O O

O

NH

S N

O

O

O

Rx-ID: 18661730 View in Reaxys 1620/3247 O

O

NH

NH

HO

O

O

O

O

Rx-ID: 18666833 View in Reaxys 1621/3247 O O

O

O

S

NH

N

O

O

O

O

O

Rx-ID: 18675044 View in Reaxys 1622/3247

NH

O

O

NH

O

O

O

HO O

Rx-ID: 19405371 View in Reaxys 1623/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

199/428

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O OH

NH

N

O

O

O

O

HO O

HN

Rx-ID: 29753164 View in Reaxys 1624/3247 O OH

NH

O

O

O

O

NH

O

Rx-ID: 39599347 View in Reaxys 1625/3247 O

O

NH

O

N

O

O

O

O

NH

O

Rx-ID: 39599360 View in Reaxys 1626/3247

Cl

N –O

Na +

O

N

O

Cl O

O

Rx-ID: 2269750 View in Reaxys 1627/3247 OH NH

N

Hal-(CH2)3OH

O

O

O

O

Rx-ID: 9443478 View in Reaxys 1628/3247

O

O

N

O

O

O

NH

NH

O

Rx-ID: 9973087 View in Reaxys 1629/3247

O

OH NH

O NH

O

Rx-ID: 12909702 View in Reaxys 1630/3247 O

O

N

O

N

O

O

O HO

Rx-ID: 29216524 View in Reaxys 1631/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

200/428

2016-08-04 14:49:45


O O HO

NH

Si NH

O

O

Rx-ID: 31850209 View in Reaxys 1632/3247 O

O HO

NH

NH O

O

Rx-ID: 31850210 View in Reaxys 1633/3247 O O

NH

Si NH

O

O

Rx-ID: 31850217 View in Reaxys 1634/3247 O

NH Br

NH

O

O

O

Rx-ID: 31850219 View in Reaxys 1635/3247

O

O

N

N

O

HO

O

OH

Rx-ID: 32506537 View in Reaxys 1636/3247 O

O F

N

F

N

Rx-ID: 38895595 View in Reaxys 1637/3247

O

NH N

O

SH

Rx-ID: 36492805 View in Reaxys 1638/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

201/428

2016-08-04 14:49:45


O O N

N

Br

SH

Rx-ID: 36492808 View in Reaxys 1639/3247 O

NH

Cl

Cl

Br

N

O

Rx-ID: 28783466 View in Reaxys 1640/3247 O

Cl

NH

Cl N

Cl

O

Rx-ID: 31808488 View in Reaxys 1641/3247

NH Br

N

Cl

Cl

O O

Rx-ID: 36051700 View in Reaxys 1642/3247

N

N O

O O

O

N

O

O

Rx-ID: 4720652 View in Reaxys 1643/3247

N

NH O

O O

O

N

O

O

Rx-ID: 17197026 View in Reaxys 1644/3247

N

NH

O

O

O

N

O

O

Rx-ID: 35686760 View in Reaxys 1645/3247

S

HN N

H N

O NH

O

S

Cl

NH 2

NH 2 O

Rx-ID: 5280264 View in Reaxys 1646/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

202/428

2016-08-04 14:49:45


NH

O

O

NH

N O

F

O

F

O

O

Rx-ID: 4764767 View in Reaxys 1647/3247

NH

O

O

O

F

O

NH

N

O

F O

Rx-ID: 28233198 View in Reaxys 1648/3247 O O

NH

F

O

F

NH

Rx-ID: 37929251 View in Reaxys 1649/3247 O

O

O F

O F

O

HO

NH

O

O

NH

O

Rx-ID: 37929292 View in Reaxys 1650/3247

O

NH

O O

O

Rx-ID: 6607567 View in Reaxys 1651/3247 O

O N

HO O NH

O

OH

Rx-ID: 35858028 View in Reaxys 1652/3247 O

O N HO

HO

OH

O

OH

NH

O

OH

Rx-ID: 35858032 View in Reaxys 1653/3247 O

O HO

O

O

O

NH O

NH OH

Rx-ID: 35858050 View in Reaxys 1654/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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O

N O

F

Rx-ID: 23818626 View in Reaxys 1655/3247

O

N O F

Rx-ID: 27863141 View in Reaxys 1656/3247

O

N O

F

Rx-ID: 29306953 View in Reaxys 1657/3247 O N Cl

O

Rx-ID: 6598301 View in Reaxys 1658/3247 O N Cl

O

Rx-ID: 6599243 View in Reaxys 1659/3247

N Cl

O

O

Rx-ID: 6602268 View in Reaxys 1660/3247 Cl

NH Br

Cl

N

O O

Rx-ID: 1647192 View in Reaxys 1661/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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N Cl

O

Rx-ID: 5600358 View in Reaxys 1662/3247

N

N

Cl

Cl

O

Rx-ID: 10800643 View in Reaxys 1663/3247

Cl

NH

N

O

O

Rx-ID: 24142597 View in Reaxys 1664/3247 O

N Cl

Rx-ID: 32140378 View in Reaxys 1665/3247 O Cl N

Rx-ID: 32140379 View in Reaxys 1666/3247 O

Cl

Cl

O N

N

Rx-ID: 38895589 View in Reaxys 1667/3247 O O

O

O

N

N –S

O

Na +

N

NH S

O

O

Rx-ID: 9291414 View in Reaxys 1668/3247 O

NH

O

N

NH S

O

Rx-ID: 14425218 View in Reaxys 1669/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

205/428

2016-08-04 14:49:45


O

O N

O

NH

O

N

NH S

O

Rx-ID: 14427089 View in Reaxys 1670/3247 O O

O

O

N

N

N

O

NH S

O

Rx-ID: 14446038 View in Reaxys 1671/3247 O O

O

OH

N

N

O

N

NH S

O

Rx-ID: 14446051 View in Reaxys 1672/3247 O NH

O S Cl

N

O

O

O

S

O

Rx-ID: 41754885 View in Reaxys 1673/3247 O NH

N O

O

S

Rx-ID: 41755071 View in Reaxys 1674/3247 NH 2

Cl

O

O O

Cl

HN O

O

Rx-ID: 38162590 View in Reaxys 1675/3247 Cl

O

HO

O

NH 2

O

O

HN

Cl

Rx-ID: 38162630 View in Reaxys 1676/3247 O

Cl

O

Cl

O

N

O O

O HN

N H

Rx-ID: 38162660 View in Reaxys 1677/3247 Cl

O

Cl O

O

NH 2 O

O

HN

Rx-ID: 38162745 View in Reaxys 1678/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

206/428

2016-08-04 14:49:45


Si

NH 2

Cl

O

O O

Cl

HN

O

O

Rx-ID: 38162902 View in Reaxys 1679/3247 OH NH Cl

N

OHCH2CH2CH2-halide

Cl

O

O

Rx-ID: 8485413 View in Reaxys 1680/3247 O NH

O

Cl

O

O

S O

O

Cl

O

N

O

Rx-ID: 11124368 View in Reaxys 1681/3247 O

NH Br

Cl

O

N

O

O

Cl

Rx-ID: 29216502 View in Reaxys 1682/3247 O Cl

NH

HO

Cl

N

Cl

OH

O

Rx-ID: 31808356 View in Reaxys 1683/3247 O Cl

NH

N

Cl

OH

Rx-ID: 31808501 View in Reaxys 1684/3247

Br

N

Br

NH

NH

O O

Rx-ID: 4269193 View in Reaxys 1685/3247

N

N O

N

O

Br

O

Rx-ID: 4609033 View in Reaxys 1686/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

207/428

2016-08-04 14:49:45


NH

N Br

I

Br

O

O

Rx-ID: 4975928 View in Reaxys 1687/3247

NH Br O

Rx-ID: 6591493 View in Reaxys 1688/3247

N Br O

Rx-ID: 6655171 View in Reaxys 1689/3247

NH Br O

Rx-ID: 6655193 View in Reaxys 1690/3247

Br

NH

O

Rx-ID: 6655194 View in Reaxys 1691/3247

Br

N

O

Rx-ID: 6655807 View in Reaxys 1692/3247

NH

N

I Br

Br O

O

Rx-ID: 8867772 View in Reaxys 1693/3247

N

N Br

N

O

N

N

O O

Br

O

O

Br

Rx-ID: 9204728 View in Reaxys 1694/3247

NH

NH

N Br

O Br O

Rx-ID: 10492140 View in Reaxys 1695/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

208/428

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Br

Br

N

O

O

NH

NH

Rx-ID: 10533981 View in Reaxys 1696/3247

NH

N

I Br

O

Br

O

Rx-ID: 10552857 View in Reaxys 1697/3247

N

NH

Br

Br

O

Rx-ID: 11767755 View in Reaxys 1698/3247

NH

N

Br

Br

O

Rx-ID: 11767916 View in Reaxys 1699/3247

NH

NH Br O

O

Rx-ID: 23322501 View in Reaxys 1700/3247

NH

NH

N

I Br

Br

O

Br

O

Rx-ID: 24197432 View in Reaxys 1701/3247

N Br

O

Rx-ID: 24553007 View in Reaxys 1702/3247

bromomethylene dimethyl ammonium bromide

NH

NH

Br

Br

O

Rx-ID: 25912109 View in Reaxys 1703/3247

Br

NH

Br

N

O

Rx-ID: 32107591 View in Reaxys 1704/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

209/428

2016-08-04 14:49:45


NH

O

N

O O

Br

Br

O

O

Rx-ID: 32107637 View in Reaxys 1705/3247

Br

NH

O

Br

O

N

O

O

O

Rx-ID: 32107640 View in Reaxys 1706/3247

NH

O

N

O S

O

Br

O

Br

O

O

Rx-ID: 32682203 View in Reaxys 1707/3247

N

S

N

O

Br

Br

O

Rx-ID: 33199470 View in Reaxys 1708/3247

N

N

N

N

Br

Br

O

Rx-ID: 34138122 View in Reaxys 1709/3247

N

N N

O

Br

Br

O

Rx-ID: 35253293 View in Reaxys 1710/3247

N

NH

Br

O

O

Rx-ID: 36090842 View in Reaxys 1711/3247 Br

Br

N

O O

NH

NH

Rx-ID: 36394380 View in Reaxys 1712/3247

S

O

Br

N

Br

N

O

Rx-ID: 36422505 View in Reaxys 1713/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

210/428

2016-08-04 14:49:45


NH

N S

Br

Br O

O

Rx-ID: 37094249 View in Reaxys 1714/3247

NH

N

DM S

Br

Br

O

O

Rx-ID: 37250115 View in Reaxys 1715/3247

Br N

Br

N

N

N

O

Rx-ID: 38026966 View in Reaxys 1716/3247

NH

O S O

N

NH

O

O

S

N H

O

N H

O

Rx-ID: 4263791 View in Reaxys 1717/3247

NH

O S O

N H

O

Rx-ID: 5829378 View in Reaxys 1718/3247

NH

NH

O S

H 2N

N H

O

O

Rx-ID: 18004990 View in Reaxys 1719/3247

N

N O

O

N

O

O

N

Cl N O

O

O

Rx-ID: 4767568 View in Reaxys 1720/3247

N

N O

O

Cl N O

O

Rx-ID: 17069635 View in Reaxys 1721/3247

NH O

N Cl O

N O

O

Cl N O

O

Rx-ID: 22866541 View in Reaxys 1722/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

211/428

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NH O

N Cl

I

O

N O

O

Cl N O

O

Rx-ID: 24575649 View in Reaxys 1723/3247

NH Cl O NH 2

O

Rx-ID: 5606843 View in Reaxys 1724/3247 O NH

Br

Br

N O

NH 2

Rx-ID: 11178864 View in Reaxys 1725/3247

OH

N

N

S

SH

O

O O

O

Rx-ID: 10161093 View in Reaxys 1726/3247

OH

N

N

S

S

O

O O

Rx-ID: 12408032 View in Reaxys 1727/3247

NH

NH

N

N

Z

O N

N

O

Rx-ID: 1704627 View in Reaxys 1728/3247

O

O

NH

N

Z

N

N O

N

Rx-ID: 20060467 View in Reaxys 1729/3247

O

O N

NH

N

Z

N N O

Rx-ID: 20060514 View in Reaxys 1730/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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N

N

N

O

O

Rx-ID: 3345730 View in Reaxys 1731/3247

(v1)

N

Cu

O

Rx-ID: 18827461 View in Reaxys 1732/3247

N

N I

O

Rx-ID: 18829053 View in Reaxys 1733/3247

N

N Br

O

O

Rx-ID: 26020391 View in Reaxys 1734/3247 N

NH

F

NH

N

F

N

F

O

NH

Rx-ID: 24001958 View in Reaxys 1735/3247 Br

NH

NH

NH

Br OH

O

OH

O

OH

O

Rx-ID: 9083727 View in Reaxys 1736/3247

O

O

NH

N

Br OH

Br OH

O

O

Rx-ID: 9100109 View in Reaxys 1737/3247

NH

NH

O

O Br OH

O

Rx-ID: 14730120 View in Reaxys 1738/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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NH Br NH

O

O

O

OH

Rx-ID: 14730121 View in Reaxys 1739/3247

NH

NH

Br OH

O

OH

O

Rx-ID: 14741571 View in Reaxys 1740/3247

O

O

NH

N

Br OH

OH

O

O

Rx-ID: 14755464 View in Reaxys 1741/3247 O

NH

Cl

Cl Cl

Cl

O

N E Cl

Rx-ID: 39589594 View in Reaxys 1742/3247 O F

NH

O S Cl

F

N

O

O

O

S

O

Rx-ID: 41754901 View in Reaxys 1743/3247 O F

NH

N

F

O

S

O

Rx-ID: 41755078 View in Reaxys 1744/3247

N

N

Br O

OH

O

O

Rx-ID: 3327285 View in Reaxys 1745/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

214/428

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N

NH

I

O

O

O

Rx-ID: 19838564 View in Reaxys 1746/3247

N

NH

OH

O

O

O

Rx-ID: 19856570 View in Reaxys 1747/3247

I

H N

S

HN

NH S

N

S

H N

N

N O

Rx-ID: 5280259 View in Reaxys 1748/3247

NH

NH

O

F F

NH

O

Tl

O

F

Si

O

O

F

O F

O

Si

F

Rx-ID: 3856893 View in Reaxys 1749/3247

NH NH

Si

I

O

O

Si

Rx-ID: 4030617 View in Reaxys 1750/3247

NH NH

Si

Br

O

O

Si

Rx-ID: 10447291 View in Reaxys 1751/3247

NH

NH O

Br

Si

Rx-ID: 12138501 View in Reaxys 1752/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

215/428

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O

NH Si

Br

Si NH

O

Rx-ID: 31850225 View in Reaxys 1753/3247 O

Si

NH Si

I NH

O

Rx-ID: 40699996 View in Reaxys 1754/3247 F

O

Br

NH

N

O HN F

Br

Rx-ID: 34946943 View in Reaxys 1755/3247

N

N

N

O

Cl Cl

O

O

Rx-ID: 3342359 View in Reaxys 1756/3247

NH

N

O NH

O

HN

HN O O

Rx-ID: 9204753 View in Reaxys 1757/3247

NH

O

NH

HN

OH

O O

Rx-ID: 14556902 View in Reaxys 1758/3247

NH

O

NH

HN

HN

O O

O

Rx-ID: 14581569 View in Reaxys 1759/3247

NH

O

NH

HN

HN

O OH

O

Rx-ID: 14582622 View in Reaxys 1760/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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O

N

N O

Rx-ID: 29338794 View in Reaxys 1761/3247 Cl

N

N

N

N

N

O

O

Rx-ID: 8897880 View in Reaxys 1762/3247 N

N

N

NH N

O O

Rx-ID: 15253533 View in Reaxys 1763/3247 O F

O

F HN

F

Rx-ID: 28907160 View in Reaxys 1764/3247 O

F

O

N

F NH

F

O

F

O

F F

HN

Rx-ID: 39599337 View in Reaxys 1765/3247 N

N

O

N

O O

Rx-ID: 6615193 View in Reaxys 1766/3247 N

N O

N O

O

Rx-ID: 6615403 View in Reaxys 1767/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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N

O O

N

N

O

Rx-ID: 6617498 View in Reaxys 1768/3247

O

O

N

O

N

O

O

O

OH

O

Rx-ID: 2371529 View in Reaxys 1769/3247 O NH

NH O

E

N

E

O

O

O

O

Rx-ID: 3345147 View in Reaxys 1770/3247

O

O

O

O N

N

Sn

F

O O

F

S O

F

O

O

Rx-ID: 4164596 View in Reaxys 1771/3247

N

NH

I

O

O

O

O

Rx-ID: 19838566 View in Reaxys 1772/3247

N

NH

OH

O

O

O

O

Rx-ID: 19856571 View in Reaxys 1773/3247

O

E NH

N

O

O

O

E O

HN

O

Rx-ID: 24789458 View in Reaxys 1774/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

218/428

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O

NH

Cl

N

O

O

O O

O

Rx-ID: 31529685 View in Reaxys 1775/3247 O

HO

N

O

O

O O

Rx-ID: 31529750 View in Reaxys 1776/3247 O

N

O O

O

E

N

O

O

Rx-ID: 32660606 View in Reaxys 1777/3247 OH

O

O

N

O

O

E

Z

N

O

racemate

N O

O

O

Rx-ID: 33293549 View in Reaxys 1778/3247

O

NH

Br

O

N

O O

Rx-ID: 1752209 View in Reaxys 1779/3247 O

O

NH

NH

O

Rx-ID: 31850214 View in Reaxys 1780/3247 O NH Br NH O

O

Rx-ID: 31850223 View in Reaxys 1781/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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O

N

O

NH

N

O

N

N

NH

N H

O

O

Rx-ID: 35858040 View in Reaxys 1782/3247

O

N

N O

Rx-ID: 32962604 View in Reaxys 1783/3247 O

NH N

Cl

O

Rx-ID: 34656670 View in Reaxys 1784/3247 O

NH N

Br

O

Rx-ID: 37227203 View in Reaxys 1785/3247 O

N

O

N

N

Rx-ID: 40759316 View in Reaxys 1786/3247 O

NH

N

Rx-ID: 40759327 View in Reaxys 1787/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

220/428

2016-08-04 14:49:45


O

N

Br

Rx-ID: 40759338 View in Reaxys 1788/3247

NH

NH

Cl S O

O

O

O

Rx-ID: 1647453 View in Reaxys 1789/3247

O O

Br

OH

N

O

N

N

O

O N

O O

Rx-ID: 9670189 View in Reaxys 1790/3247

OH N Br

O

O N

N O

O

O

N O

O

Rx-ID: 9670190 View in Reaxys 1791/3247

O O

N

OH

O

N

O

O

N

N

O

Rx-ID: 13617465 View in Reaxys 1792/3247

O O

N O

N

N

O

O

N O

O

Rx-ID: 13629302 View in Reaxys 1793/3247

O O

N O

N

N O

O

O

N O

O

Rx-ID: 13629917 View in Reaxys 1794/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

221/428

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O

O O

O

N

O

N

O

N

N

O

Rx-ID: 13630680 View in Reaxys 1795/3247

O

O O

O

N

O

N

O

N

N

O

O

Rx-ID: 13632118 View in Reaxys 1796/3247

O

O O

O

O

O

S O

N

Cl

HN

N H 2N

O

Rx-ID: 33590204 View in Reaxys 1797/3247

O NH

O

O

N H 2N

O

Rx-ID: 33590229 View in Reaxys 1798/3247

O

NH

O

HO

N H 2N

O

Rx-ID: 33590253 View in Reaxys 1799/3247

O N NH

O N

N

Cl O

H

O

Rx-ID: 1647342 View in Reaxys 1800/3247 O NH 2 N

O

Rx-ID: 6664539 View in Reaxys 1801/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

222/428

2016-08-04 14:49:45


O N

O

E HN

Rx-ID: 23353071 View in Reaxys 1802/3247

O N N

O

H

Rx-ID: 23725839 View in Reaxys 1803/3247

O

NH

N N

O

O

H

Rx-ID: 24024547 View in Reaxys 1804/3247 O

O H 2N

O

NH

Cl

N

N

O

Rx-ID: 28970293 View in Reaxys 1805/3247 O

O O

NH

O

NH

Cl

N

O

N

O

Rx-ID: 29073152 View in Reaxys 1806/3247

N

N

O

Rx-ID: 6602057 View in Reaxys 1807/3247

N

NH

N

Cl N

O O

Rx-ID: 28116189 View in Reaxys 1808/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

223/428

2016-08-04 14:49:45


O

NH N

N

Cl

O

N

Rx-ID: 29217476 View in Reaxys 1809/3247 O

NH

N

Cl

Cl

N

H

O

N

Rx-ID: 37227202 View in Reaxys 1810/3247 O

NH

-1 N

Cl

HCl

N

O

N

Rx-ID: 40253155 View in Reaxys 1811/3247 O

F

F

F

F

F

F

F

NH 2

N

F

I

Rx-ID: 39930862 View in Reaxys 1812/3247 F F

O

F

F

F

F

F N

F

NH 2

Si

Rx-ID: 39930871 View in Reaxys 1813/3247 O

F

F

F

F F

F

NH 2 F

N

F

Rx-ID: 39930878 View in Reaxys 1814/3247 O

F

F

F

F

F

F NH

F

N

F

Rx-ID: 39930882 View in Reaxys 1815/3247 O

F

F

F

F F

N F

N

O

F F

N

Rx-ID: 39930893 View in Reaxys 1816/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

224/428

2016-08-04 14:49:45


O

F

F

F

F F

N

O

F

N

N

F

F

Rx-ID: 39930908 View in Reaxys 1817/3247 O

F

F

F

F F

F

NH 2

N

F F

Rx-ID: 39930914 View in Reaxys 1818/3247 O

I

F

F

NH 2

F

F

N

F

F

F

F

Rx-ID: 39930918 View in Reaxys 1819/3247

O

Si

F

F F

F F

N

NH 2

F

F F

Rx-ID: 39930922 View in Reaxys 1820/3247 O F

F NH

F

F

F

N

F

F

F

Rx-ID: 39930926 View in Reaxys 1821/3247

O N

O

O

O

Rx-ID: 5612558 View in Reaxys 1822/3247 O

O O

O

O

NH

O

O O

N O

O

Rx-ID: 35135711 View in Reaxys 1823/3247

O

O

NH

O

O

O

N

O O

Rx-ID: 1647231 View in Reaxys 1824/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

225/428

2016-08-04 14:49:45


NH

O

O

O

O

O

O

N

O

O O

Rx-ID: 1647236 View in Reaxys 1825/3247

O

O

NH

O

O

N

Cl

O

O

Rx-ID: 1647438 View in Reaxys 1826/3247

O

NH

O

Br

O

N

O

O O

Rx-ID: 1703395 View in Reaxys 1827/3247 O O

NH

NH

N

O

O O

O

Rx-ID: 1945751 View in Reaxys 1828/3247

O

NH

Cl

O

N

O

O

O O

Rx-ID: 2045358 View in Reaxys 1829/3247 O O

N

N

N

O

O O

O

Rx-ID: 2436478 View in Reaxys 1830/3247

O

N

N

O

O

O

N

O

O

Rx-ID: 3345448 View in Reaxys 1831/3247 O O

N

O

Rx-ID: 5615241 View in Reaxys 1832/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

226/428

2016-08-04 14:49:45


O O N

O

Rx-ID: 6659266 View in Reaxys 1833/3247

N

O

O

O

Rx-ID: 6666354 View in Reaxys 1834/3247

N O O

O

Rx-ID: 6860685 View in Reaxys 1835/3247 OH O

O

NH

N

HO

O

Br

O

Rx-ID: 8742259 View in Reaxys 1836/3247

O

O

O

O

N

N

N

O

Rx-ID: 9098690 View in Reaxys 1837/3247

N

N O

N

O

O

Se

O O

O O

Rx-ID: 9240668 View in Reaxys 1838/3247

O

O O N

O N

OH

O

Rx-ID: 10055847 View in Reaxys 1839/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

227/428

2016-08-04 14:49:45


NH

NH

N

O

O

O O

O

O

Rx-ID: 10429923 View in Reaxys 1840/3247

O

P+ Br–

O

O

NH

NH

O

O

O

Rx-ID: 18503868 View in Reaxys 1841/3247

O

NH

O

N

O O

O

Rx-ID: 19310367 View in Reaxys 1842/3247

O

NH O

N

O

Rx-ID: 19527135 View in Reaxys 1843/3247 O OH

N

O

O O

N

OH

O

Rx-ID: 20513197 View in Reaxys 1844/3247 O O

N

O

O

O O

N

O

Rx-ID: 20517192 View in Reaxys 1845/3247 O O

N

O

OH

O O

N

O

Rx-ID: 20519482 View in Reaxys 1846/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

228/428

2016-08-04 14:49:45


O NH

Br

O

O N

O

O

O

Rx-ID: 23141545 View in Reaxys 1847/3247 O

O

N O

Rx-ID: 23428004 View in Reaxys 1848/3247

Cl

NH

NH

O

O

O O

Cl

O

O

O

Rx-ID: 23658084 View in Reaxys 1849/3247 O O N O

Rx-ID: 23817982 View in Reaxys 1850/3247

O

O

NH

aqueous potassium hydroxide

O

O

O

N

O O

Rx-ID: 24577980 View in Reaxys 1851/3247 O NH

O

O N

O

O

O

Rx-ID: 25936947 View in Reaxys 1852/3247

O O

NH N

O

Rx-ID: 31768149 View in Reaxys 1853/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

229/428

2016-08-04 14:49:45


O O

O

N O O

N O

Rx-ID: 32962605 View in Reaxys 1854/3247 O

O

N

N

O

O

O

HO

Rx-ID: 34984113 View in Reaxys 1855/3247 O

N

NH

O O HO

Rx-ID: 34984152 View in Reaxys 1856/3247 O

N

O

Br O

O HO

Rx-ID: 34984228 View in Reaxys 1857/3247

N

O

O

O

O

O

O

O

O

O

N

O

Rx-ID: 35951965 View in Reaxys 1858/3247 O

O

O

O

N

N

OH

O

Rx-ID: 37062064 View in Reaxys 1859/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

230/428

2016-08-04 14:49:45


O

O

NH N

O

O

Rx-ID: 37062120 View in Reaxys 1860/3247 O

O

NH N

O O

O

Rx-ID: 37062125 View in Reaxys 1861/3247

O

O O

O

N

N

Cl

O

Rx-ID: 37976282 View in Reaxys 1862/3247

O

O

N

O

O

N

N

N

O

Rx-ID: 38026961 View in Reaxys 1863/3247 O

O

O N

N

O

O N

O

Rx-ID: 38484003 View in Reaxys 1864/3247 O NH

O O

O

N O

Rx-ID: 38484023 View in Reaxys 1865/3247

N

NH N O O

Rx-ID: 5612200 View in Reaxys 1866/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

231/428

2016-08-04 14:49:45


O O

N

NH

N

NH

Si

O

O

O

HO

Rx-ID: 1796360 View in Reaxys 1867/3247

N O O

Rx-ID: 6661098 View in Reaxys 1868/3247

N O O

Rx-ID: 6661112 View in Reaxys 1869/3247

N O O

Rx-ID: 6661113 View in Reaxys 1870/3247

N O O

Rx-ID: 6661982 View in Reaxys 1871/3247

O

N

N

O

N

O

O

Rx-ID: 28762333 View in Reaxys 1872/3247 O O

O

O

N

N

Rx-ID: 38895594 View in Reaxys 1873/3247

O

NH HBr H 2N

O

O

S

N Cl

S NH

O

Rx-ID: 32258232 View in Reaxys 1874/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

232/428

2016-08-04 14:49:45


O

O

O

Br

N

S

Cl

NH

O

Rx-ID: 32465093 View in Reaxys 1875/3247

O S

N

NH

O

S NH

Rx-ID: 39257845 View in Reaxys 1876/3247 Cl HN

Cl

Z E

E N

O

O

O

E E

NH

NH Cl

Rx-ID: 42319333 View in Reaxys 1877/3247

O O

Br

OH

N

O

N O

N

O N

O

O

Rx-ID: 9670071 View in Reaxys 1878/3247

OH O

N

N

Br

O

N

O

O

O

N O

O

Rx-ID: 9670072 View in Reaxys 1879/3247

O O

N

OH

O

N O

O

N

N

O

Rx-ID: 13617464 View in Reaxys 1880/3247

O O

N O

N O

N O

N O

O

Rx-ID: 13629301 View in Reaxys 1881/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

233/428

2016-08-04 14:49:45


O O

N O

N

N

O

O

N

O

O

O

Rx-ID: 13629916 View in Reaxys 1882/3247

O

O

O

N

O

O

O

N

N

N O

Rx-ID: 13630679 View in Reaxys 1883/3247

O

O

O

N

O

O

N

O

N

N

O

O

Rx-ID: 13632117 View in Reaxys 1884/3247 O

NH

N

O

N

N

O

Cl O

O

O

Rx-ID: 1751858 View in Reaxys 1885/3247

NH

NH

N

O

N

N

O O

O O

O

Rx-ID: 4269142 View in Reaxys 1886/3247

N

NH

O

O O

Rx-ID: 5616416 View in Reaxys 1887/3247

O N

NH

OH

2-nitro-m-cresol; 6-nitro-m-cresol

O

N

O O

O

Rx-ID: 18009578 View in Reaxys 1888/3247 O O

N

NH

N

O O

N

O O

O

Rx-ID: 18032373 View in Reaxys 1889/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

234/428

2016-08-04 14:49:45


O

H N

O O

N

Rx-ID: 24238294 View in Reaxys 1890/3247

NH

N

O O

O

O

O

N

NH

N

O

Rx-ID: 29216488 View in Reaxys 1891/3247

N

NH O

O

O

OH NH

Rx-ID: 34515806 View in Reaxys 1892/3247

N O

N

O

N

O

O

O

O

NH

NH

Rx-ID: 34515971 View in Reaxys 1893/3247 O

NH

O N

N

O

NH

O

O

N

O

Rx-ID: 34516030 View in Reaxys 1894/3247 O

HO

NH NH

O N

O

Rx-ID: 34516157 View in Reaxys 1895/3247 O

NH

O N

O

Rx-ID: 36393341 View in Reaxys 1896/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

235/428

2016-08-04 14:49:45


O

O NH

F

F

O N

F

O

E

NH

E

N

N

N

O

Rx-ID: 23398929 View in Reaxys 1897/3247

N HO O

N

Rx-ID: 5615534 View in Reaxys 1898/3247

N O NH 2

O

Rx-ID: 5829602 View in Reaxys 1899/3247 O

O

N

N H

N

Cl

H

N

HO

O

Rx-ID: 23742726 View in Reaxys 1900/3247

O

O

O

N N

O

O

O

O

N

NH 2

N

N

N

N

Rx-ID: 27955470 View in Reaxys 1901/3247 O

N

N

dimethylamine ethyl halide OH

O N

O

Rx-ID: 32391704 View in Reaxys 1902/3247

NH

O

O

O

O

O

NH

O

O

Rx-ID: 249357 View in Reaxys 1903/3247

NH

N O

O

NH

O

O

O

O

O O

Rx-ID: 1960116 View in Reaxys 1904/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

236/428

2016-08-04 14:49:45


OH

O O

O

O

N

O

N

O

O

Rx-ID: 3264536 View in Reaxys 1905/3247 O O

O

NH

Cl

O

O

N

O O O

Rx-ID: 3355445 View in Reaxys 1906/3247

O

NH

O

O O

Rx-ID: 5492616 View in Reaxys 1907/3247

O

NH

O

O O

Rx-ID: 5612179 View in Reaxys 1908/3247

NH

O

NH

O

N O

O

O

O

O

O

Rx-ID: 8677186 View in Reaxys 1909/3247 O

O N

N

N

O O

O

O

O

Rx-ID: 9973078 View in Reaxys 1910/3247 O

O

N

NH

O

O

O

O

Rx-ID: 12955192 View in Reaxys 1911/3247

O

O

O

N O O

O

O

Rx-ID: 12958599 View in Reaxys 1912/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

237/428

2016-08-04 14:49:45


O O

O

N

O

N

O

O

N O

O

O

O

Rx-ID: 12960311 View in Reaxys 1913/3247 O

O

N

O N

O

O

O

O

O

Rx-ID: 12960476 View in Reaxys 1914/3247 O O

O

NH

O

N

O

Rx-ID: 19484757 View in Reaxys 1915/3247 O O

O O

N O

N

O O O

Rx-ID: 19497650 View in Reaxys 1916/3247

N+

N

O

O

N

O

O– O

HO

O

N

S OO

O O

Rx-ID: 19518622 View in Reaxys 1917/3247 O O

H 2N O

O

N

N

O

O O

Rx-ID: 19525788 View in Reaxys 1918/3247 OH O

NH

O

O

N

O

Rx-ID: 19527709 View in Reaxys 1919/3247 OH O

NH

O

O

N

O O

Rx-ID: 19529396 View in Reaxys 1920/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

238/428

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OH

NH

O

O

O

O

O

NH

O

Rx-ID: 31215112 View in Reaxys 1921/3247 O O

NH

O N

O

O

Cl

O O

O

Rx-ID: 37471377 View in Reaxys 1922/3247 O

O

O O

O O

O

HO

NH

O

O

NH

O

Rx-ID: 37929235 View in Reaxys 1923/3247 O O

NH

O

O

O

NH

Rx-ID: 37929270 View in Reaxys 1924/3247 O O

NH

O

O

O

NH

O

Rx-ID: 37929299 View in Reaxys 1925/3247

O

O

NH

N

O

O

O

O O O

NH

Rx-ID: 39662339 View in Reaxys 1926/3247

O

O

NH

O

HO

O

NH

Rx-ID: 39662344 View in Reaxys 1927/3247 O H 2N

O

O

NH

O

O

Rx-ID: 42063716 View in Reaxys 1928/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

239/428

2016-08-04 14:49:45


O

O

E

O

H N

N

O NH

O

O

O

Rx-ID: 42063731 View in Reaxys 1929/3247 O O NH

O

O

N

O NH

O

O

O

Rx-ID: 42063737 View in Reaxys 1930/3247 O O

O

O

O

NH

O

O

Rx-ID: 42064112 View in Reaxys 1931/3247

NH

NH

NH

NH

OH

O

O

O OH

O

HO

HO

Rx-ID: 1647221 View in Reaxys 1932/3247

O

NH

O

O

O

O N

O O

Rx-ID: 4558178 View in Reaxys 1933/3247

N OH

O O

Rx-ID: 6662625 View in Reaxys 1934/3247

OH N

N

O

OH

O

Rx-ID: 9157422 View in Reaxys 1935/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

240/428

2016-08-04 14:49:45


OH N

N

OH

O

Rx-ID: 14750971 View in Reaxys 1936/3247

O

N O O

Rx-ID: 29338796 View in Reaxys 1937/3247 O I O

O

O

N O

O

N

N

O O

O

Rx-ID: 34490749 View in Reaxys 1938/3247 O

O

NH N

O

OH

Rx-ID: 37062119 View in Reaxys 1939/3247 O

O

NH OH

Cl

O

N

O

OH

Rx-ID: 37062124 View in Reaxys 1940/3247 O

F

F F

F F HN

N

O

F HN

Cl

Cl

Rx-ID: 29854373 View in Reaxys 1941/3247

NH

Br

Cl

N Cl

O O

Rx-ID: 2898454 View in Reaxys 1942/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

241/428

2016-08-04 14:49:45


O

NH

Br

Cl

Cl

N

O

Rx-ID: 28783487 View in Reaxys 1943/3247 O

N

O

Cl

NH

Cl

N H

Rx-ID: 33441183 View in Reaxys 1944/3247

N

N O

O O

O

N

O

O

Rx-ID: 4720528 View in Reaxys 1945/3247

NH O O

N

O

O

Rx-ID: 6667770 View in Reaxys 1946/3247

N

NH O

O

O

N

O

O

Rx-ID: 13946165 View in Reaxys 1947/3247

N

N O

O

O

N

O

O

Rx-ID: 13946946 View in Reaxys 1948/3247

N

NH O

O O

O

N

O

O

Rx-ID: 35686789 View in Reaxys 1949/3247 O N

NH

NH

N

O

N

O

O

Rx-ID: 35446579 View in Reaxys 1950/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

242/428

2016-08-04 14:49:45


O N

NH

NH

N

O

O

Rx-ID: 40466731 View in Reaxys 1951/3247 H 2N

O

N F O

Rx-ID: 6612142 View in Reaxys 1952/3247 O

N

O

O

S

S

N

NH

O

O

K

N

O

O

Rx-ID: 9661425 View in Reaxys 1953/3247 O

O

O

S

S

N

NH

O

O

N

O

Rx-ID: 13629432 View in Reaxys 1954/3247

Cl

N

Cl

NH

O

NH Cl

Cl Cl

Cl

O

Rx-ID: 9735620 View in Reaxys 1955/3247 N Br O

NH N

Br

O Br

O

Rx-ID: 32394163 View in Reaxys 1956/3247 H 2N

N

O NH

N

NH

O

Br

Br

O

Rx-ID: 32394170 View in Reaxys 1957/3247 N

Br NH

Br

NH

Br

O

Rx-ID: 32394179 View in Reaxys 1958/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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N

O Br NH

OH NH Br

O

Rx-ID: 32394716 View in Reaxys 1959/3247 Br

N

N

NH

O

NH

Rx-ID: 36258633 View in Reaxys 1960/3247 Br

Br

N N

N

O O

NH

NH

Rx-ID: 36394379 View in Reaxys 1961/3247 O

N

F

O

N

O

O O

F

N

O

Rx-ID: 42233961 View in Reaxys 1962/3247 O NH

O

F

O

O

F

N

O

Rx-ID: 42234045 View in Reaxys 1963/3247

NH

NH

N

S

O

O

O

S

O

O

O

Rx-ID: 3343565 View in Reaxys 1964/3247 OH

O

N

N S

S

O

O

O

O

Rx-ID: 10080941 View in Reaxys 1965/3247 OH N Cl

2

O

S–

Na +

N S

O

O– O

O

Rx-ID: 10111875 View in Reaxys 1966/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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OH N

N

S

Cl

O

O

O

Rx-ID: 12646250 View in Reaxys 1967/3247 O O O SH

N

N

Cl

O

O O

Rx-ID: 38882793 View in Reaxys 1968/3247 O

OH

I O

O

O

N O

N

N O

O

O N

O

O

O

Rx-ID: 34490748 View in Reaxys 1969/3247

N O Cl

O

Rx-ID: 6662810 View in Reaxys 1970/3247 Cl

NH

Cl

Br

N

O

O

Rx-ID: 4336838 View in Reaxys 1971/3247

N Cl

O

Rx-ID: 5606861 View in Reaxys 1972/3247 O

O Cl

N

N

Cl

Rx-ID: 38895596 View in Reaxys 1973/3247 O NH

N O

O

S N

O N

N

Rx-ID: 40266713 View in Reaxys 1974/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

245/428

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O N

NH

NH N+

O

Cl

O Cl

Cl –

Cl

Cl

Cl

E

O

N

Rx-ID: 9640638 View in Reaxys 1975/3247 O Cl

Cl

Cl

NH N+

O

Cl

N

NH

O Cl

Cl –

E O

N

Rx-ID: 9642526 View in Reaxys 1976/3247 O

NH

N

O

N

N

Cl

Cl Cl

O O

Rx-ID: 29000183 View in Reaxys 1977/3247

NH N Cl

O

Rx-ID: 5610484 View in Reaxys 1978/3247 O

F F F

N

F N F

F

Rx-ID: 25191846 View in Reaxys 1979/3247

O

O

NH

NH

N H

O

O

O

O

Si

O

O

Rx-ID: 3859164 View in Reaxys 1980/3247

NH

O

O

NH

N O

O

O

Cl

Cl

O

Rx-ID: 271013 View in Reaxys 1981/3247

O

NH

O

Cl O

Rx-ID: 5828521 View in Reaxys 1982/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

246/428

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O N Cl O O

Rx-ID: 6662474 View in Reaxys 1983/3247

O O

NH Cl

N

C2H5OCO-halide

Cl

O O

Rx-ID: 8485446 View in Reaxys 1984/3247 O

NH Cl

O

N

CH3OCOCH2-halide

Cl

O O

Rx-ID: 8485478 View in Reaxys 1985/3247

O

O N

N

O

NH O

O

O O

O

Cl

Br

Rx-ID: 9606151 View in Reaxys 1986/3247

NH

O

O

NH

N O

Cl

O

Cl

O

O

Rx-ID: 22964500 View in Reaxys 1987/3247

–O

O

NH

O Na +

O

Cl O

Rx-ID: 23572058 View in Reaxys 1988/3247

Cl

NH

Cl

O

N

O

NH

O O

O O

Rx-ID: 25584702 View in Reaxys 1989/3247

NH

O

Cl

O

O

NH Cl

Cl

N O

Cl

O

O

Rx-ID: 25902072 View in Reaxys 1990/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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NH

O

O

O

Cl

O

NH

N

O

Cl O

Rx-ID: 28233199 View in Reaxys 1991/3247

Cl

O

N

O

NH

O

Cl

O

O

Rx-ID: 31739471 View in Reaxys 1992/3247

Cl

O

Cl

O

NH

O O

O

O

N

O

O

Rx-ID: 31739474 View in Reaxys 1993/3247

Cl

NH

Cl

O

O

NH

O

O O

Rx-ID: 32214212 View in Reaxys 1994/3247

O Cl

O

NH

O

N

Cl

Cl

O

O O

Rx-ID: 34242694 View in Reaxys 1995/3247 O

O

O Cl

O Cl

O

HO

NH

O

O

NH

O

Rx-ID: 37929293 View in Reaxys 1996/3247

NH

O

O

NH

N

O

O

O

Cl

Cl

O

Rx-ID: 42064214 View in Reaxys 1997/3247 O

Cl NH

O

O

N

O

O

NH

O

Cl

Rx-ID: 42064215 View in Reaxys 1998/3247

O

E N

H N

O

Cl

O

O

NH

O

Cl

Rx-ID: 42064221 View in Reaxys 1999/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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Cl NH

Cl

O

N

Br O

O

O

Rx-ID: 9641039 View in Reaxys 2000/3247 Cl NH

N

O

O O

Rx-ID: 13512348 View in Reaxys 2001/3247 O NH Br

N

Cl

O

O

O

Cl

Rx-ID: 28907667 View in Reaxys 2002/3247

O

N Cl O

Rx-ID: 29338793 View in Reaxys 2003/3247

O

Cl

N

O

Rx-ID: 29338798 View in Reaxys 2004/3247

O

NH Br O

Rx-ID: 6593448 View in Reaxys 2005/3247 Br

O

Br

O

I N

NH

Rx-ID: 10552186 View in Reaxys 2006/3247 Br

Br

NH

O

N

Rx-ID: 11747147 View in Reaxys 2007/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

249/428

2016-08-04 14:49:45


O O

NH

O

Br

S O

O

Br

N

O

Rx-ID: 32682189 View in Reaxys 2008/3247 O

NH

Br

S

Br

N

O

Rx-ID: 37094250 View in Reaxys 2009/3247 O

NH

Br

DES

Br

N

O

Rx-ID: 37250114 View in Reaxys 2010/3247

NH

NH

N H

Cl S O

O

N S O

O

O

O

Rx-ID: 3289089 View in Reaxys 2011/3247

NH

NH N S O

O

O

O

Rx-ID: 21936993 View in Reaxys 2012/3247 O S O

HN N H

H N

sodium chloride

O S

NH

O

O

Rx-ID: 25034128 View in Reaxys 2013/3247

N O

N

S

NH

N

O

O

O

S

O

O NH

Rx-ID: 29868998 View in Reaxys 2014/3247 O O

NH

O S

N

N O

Cl

O

S

O

N

Rx-ID: 39693095 View in Reaxys 2015/3247 NH

N OH

NH

O

O

NH Cl

H

O

Rx-ID: 1877009 View in Reaxys 2016/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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N Cl O NH 2

O

Rx-ID: 5613332 View in Reaxys 2017/3247 NH

N NH

NH

O

Cl

H

O

Rx-ID: 19147028 View in Reaxys 2018/3247 F

O

F O NH

F

N

O

O

O

NH

F

O

Rx-ID: 42064216 View in Reaxys 2019/3247 F

O

F

O F

NH 2

NH

F

O

Rx-ID: 42064230 View in Reaxys 2020/3247

N

H N

F

F

O O

O O

NH

F

F

O

Rx-ID: 42064236 View in Reaxys 2021/3247 O

N

O

O

O

S

O

S

N

N

O

O

O

Rx-ID: 9670625 View in Reaxys 2022/3247 O O

NH

O S Cl

O

N

O

O

O

S

O

Rx-ID: 41755058 View in Reaxys 2023/3247 O

O

NH O S Cl

O

O

N

O

S O

O

Rx-ID: 41985069 View in Reaxys 2024/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

251/428

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O

NH Br N

O

Rx-ID: 38847964 View in Reaxys 2025/3247 O

N Br N

O

Rx-ID: 38848019 View in Reaxys 2026/3247 Cl

O NH

O

N

OH

N

Cl

OH

O

O

OH

OH

O

Rx-ID: 3815276 View in Reaxys 2027/3247 Cl NH

OH

N

I

O

O

OH

Rx-ID: 19838565 View in Reaxys 2028/3247

Br

Br

NH N

NH

O

O

O O

Rx-ID: 3343522 View in Reaxys 2029/3247 O

Br

NH

O

N

O

O

NH

Br

Rx-ID: 10534113 View in Reaxys 2030/3247 O

Br

N

NH

O

O NH

O

Br

Rx-ID: 11231864 View in Reaxys 2031/3247 O

O N O

N

Br

O N O

Rx-ID: 28628834 View in Reaxys 2032/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

252/428

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O

O

HN

N+

Cl

O

Cl –

NH

Br

Br

Rx-ID: 29134897 View in Reaxys 2033/3247 O NH

N

O

O

O

Br

O

HN

Rx-ID: 29216486 View in Reaxys 2034/3247 O

O

O

O

O Br

N

N

N

NH

Br

Rx-ID: 40838571 View in Reaxys 2035/3247 O

O

O Br

NH

Br

O

Rx-ID: 40838585 View in Reaxys 2036/3247 O

O

O

O NH

Br

O

NH

Br

Rx-ID: 40838597 View in Reaxys 2037/3247 O

O

O

O

Br

NH

OH

NH

Br

Rx-ID: 40838607 View in Reaxys 2038/3247 O

O

HN

N

O

O

Br

Br

NH

Rx-ID: 40838629 View in Reaxys 2039/3247 O

NH

Br

Br

N O

Rx-ID: 42197212 View in Reaxys 2040/3247 O Br

Br N O

N

O N O

Rx-ID: 42197223 View in Reaxys 2041/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

253/428

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O

NH

Br

Br

N O

Rx-ID: 42197240 View in Reaxys 2042/3247 O

Br

Br

N

N

OH

O

Rx-ID: 42197266 View in Reaxys 2043/3247

NH

NH N

N

N

O

Rx-ID: 33111786 View in Reaxys 2044/3247 O O

NH

O

Br O

N

O

O

Rx-ID: 40525085 View in Reaxys 2045/3247 O

O N

O

NH

O

N

O

O

O

Rx-ID: 35858044 View in Reaxys 2046/3247

N

N

Si

Br

Si

O

O

Rx-ID: 10332278 View in Reaxys 2047/3247 O F

O O

HN

Cl

Rx-ID: 27739450 View in Reaxys 2048/3247

NH

Cl

N Cl Cl

O

O

Rx-ID: 24123604 View in Reaxys 2049/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

254/428

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Cl

NH

Cl

N

Cl

Cl

Br

O

O

Rx-ID: 24124144 View in Reaxys 2050/3247 Cl

O

N Cl

Rx-ID: 32140380 View in Reaxys 2051/3247 O Cl N Cl

Rx-ID: 32140385 View in Reaxys 2052/3247

N

N

N

N

N

O I

O

N

Rx-ID: 41148971 View in Reaxys 2053/3247 I

O

O

N

N

O

O

O

N

O

O

Rx-ID: 8699650 View in Reaxys 2054/3247 O

O

Cl NH

O N

O

O

O

Rx-ID: 10534567 View in Reaxys 2055/3247 O

NH N O

O

Rx-ID: 11438655 View in Reaxys 2056/3247 O NH N O

O

Rx-ID: 11470352 View in Reaxys 2057/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

255/428

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O N

Cl N

NH

O

O

Rx-ID: 11890262 View in Reaxys 2058/3247 O O

O

N

N

O

E NH

O

O

Rx-ID: 23739813 View in Reaxys 2059/3247

O NH N

O

Cl O O

Rx-ID: 2857805 View in Reaxys 2060/3247

N

N OH

O

O

O

Rx-ID: 5071680 View in Reaxys 2061/3247

N

O

CH2C(OSiMe3)CHCH3-TiCp2 O O

Rx-ID: 16567203 View in Reaxys 2062/3247

N

N

N O

O O

Rx-ID: 16569587 View in Reaxys 2063/3247

NH

Br N

O O

Rx-ID: 9180855 View in Reaxys 2064/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

256/428

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O

NH Br

N

O

Rx-ID: 28748741 View in Reaxys 2065/3247 O NH

N I O

Rx-ID: 34827516 View in Reaxys 2066/3247 O N Br

Rx-ID: 40759318 View in Reaxys 2067/3247

O N

N

O

N

Rx-ID: 40759320 View in Reaxys 2068/3247 O N

NH

Rx-ID: 40759329 View in Reaxys 2069/3247 O

NH F

O

N

F

Cl

F

F

Rx-ID: 24141528 View in Reaxys 2070/3247 O

O S

NH

O

N

S Cl

Cl

O

Cl

O

O

Rx-ID: 29000189 View in Reaxys 2071/3247

Cl

Cl

O

NH

OH

O Cl

O

O

Cl

NH

O

Rx-ID: 42063743 View in Reaxys 2072/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

257/428

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Cl

O

Cl

OH Cl

NH 2

NH

Cl

O

Rx-ID: 42064037 View in Reaxys 2073/3247

O

E

H N

N

O

Cl

Cl

OH

O NH

Cl

Cl

O

Rx-ID: 42064121 View in Reaxys 2074/3247

Cl

Cl

O

NH

O OH

O

Cl

Cl

NH

O

Rx-ID: 42064154 View in Reaxys 2075/3247 O N

O

E N

Rx-ID: 23353070 View in Reaxys 2076/3247 O

H 2N

O O

O

Cl

N

N

N H

Rx-ID: 33550447 View in Reaxys 2077/3247 O H 2N

O O

O

N

N

Br

N H

Rx-ID: 33550451 View in Reaxys 2078/3247

NH

N

HN NH

N O O

N OH

HO

NH

N

NH

Rx-ID: 26009918 View in Reaxys 2079/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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NH NH

N

N OH

HO

N O

NH

N

Rx-ID: 26009919 View in Reaxys 2080/3247

NH

NH

Cl

Cl O

Br

O

Rx-ID: 4245209 View in Reaxys 2081/3247

NH

NH

Br

Br O

Cl

O

Rx-ID: 4245335 View in Reaxys 2082/3247

Cl

Cl

NH

NH

O

Br

O

Rx-ID: 4247132 View in Reaxys 2083/3247

Br

Br

NH

NH

O

Cl

O

Rx-ID: 4247134 View in Reaxys 2084/3247 Br

Br

Cl

Cl

N

O O

NH

NH

Rx-ID: 36394385 View in Reaxys 2085/3247 O

NH

Br

N

O Br

O

Cl NH

Rx-ID: 40502298 View in Reaxys 2086/3247 O

F F

N

F F

Rx-ID: 32140494 View in Reaxys 2087/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

259/428

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O O

NH O

O

N

O

O

O

O

O

Rx-ID: 2371591 View in Reaxys 2088/3247 O N

O

O N

N

O O

E

O

O

O

O

E O

O

O

Rx-ID: 3351760 View in Reaxys 2089/3247 O O

NH

O

N

O

O

Rx-ID: 1752211 View in Reaxys 2090/3247

NH

NH

OH

O I

O

E

O

O HO

Rx-ID: 1795870 View in Reaxys 2091/3247 O N

O N OH

O

E I

O

HO

Rx-ID: 1855991 View in Reaxys 2092/3247

O

NH

Cl

N

O

O O

O O

Rx-ID: 2045359 View in Reaxys 2093/3247

N

O

O

O

Rx-ID: 6666259 View in Reaxys 2094/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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N

O

O

O

Rx-ID: 6669581 View in Reaxys 2095/3247

O

NH

O

O

Br N

O O

O

Rx-ID: 8742262 View in Reaxys 2096/3247 O

O O

O

N

O

N

N

O

Rx-ID: 9735624 View in Reaxys 2097/3247

NH

NH O

E

O

O HO

Rx-ID: 20002323 View in Reaxys 2098/3247 O N

OH N

O

E HO

Rx-ID: 20166802 View in Reaxys 2099/3247 O N

O N

O

E HO

Rx-ID: 20167569 View in Reaxys 2100/3247 O N

O N

E O

O

HO

Rx-ID: 20168643 View in Reaxys 2101/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

261/428

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O N

O

anhydroformaldehyde o-toluidine

N

O

E

O HO

Rx-ID: 20171137 View in Reaxys 2102/3247 O O N

N

N

O

E

O

E HO

Rx-ID: 20171480 View in Reaxys 2103/3247

O O N

O

Rx-ID: 23725806 View in Reaxys 2104/3247 O

N O O

Rx-ID: 25540048 View in Reaxys 2105/3247 O O

O

NH

N O

O

O

O

O

O

Rx-ID: 28595155 View in Reaxys 2106/3247 O NH

O

O O

O

N O

O

O

O

Rx-ID: 28610849 View in Reaxys 2107/3247 O

NH N

O O

Rx-ID: 34567102 View in Reaxys 2108/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

262/428

2016-08-04 14:49:45


O

NH

tert-butyl 2-haloacetate

N

O

O O

Rx-ID: 34567156 View in Reaxys 2109/3247 O

N

NH

O

Br O

O O O

Rx-ID: 34984157 View in Reaxys 2110/3247 O

NH

O

O

N

O

O

O O

O

O

Rx-ID: 35518870 View in Reaxys 2111/3247 O

O

O

NH

O

O

N

O O

O

O

Rx-ID: 35518985 View in Reaxys 2112/3247 O

O

NH

Br

N

O

O

O

O

Rx-ID: 36406806 View in Reaxys 2113/3247 O

O

O

O

O

O N

N

Rx-ID: 38895590 View in Reaxys 2114/3247 O

O O

O

O

O N

N

Rx-ID: 38895591 View in Reaxys 2115/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

263/428

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NH

O

O

O

O

O

O

O N

O

O

Rx-ID: 42319523 View in Reaxys 2116/3247

O

NH

O N

O

Rx-ID: 42319526 View in Reaxys 2117/3247

N

N

O

N OH

O O

Rx-ID: 5061390 View in Reaxys 2118/3247

N O O

Rx-ID: 6662686 View in Reaxys 2119/3247 O

H N

HN

N

Rx-ID: 23722037 View in Reaxys 2120/3247

O

N

Br

Cl

S N

O

Rx-ID: 32465084 View in Reaxys 2121/3247

Si

Si N

N

N

O

Br

O

Rx-ID: 3345904 View in Reaxys 2122/3247

Si

NH

N

Si Cl

O

O

Rx-ID: 4607603 View in Reaxys 2123/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

264/428

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Si NH

N

/PBHBF037--995/

O

Rx-ID: 18643963 View in Reaxys 2124/3247

Si

Si

N

N

O

Rx-ID: 18645298 View in Reaxys 2125/3247

Si N

Si Cl

O

Rx-ID: 18659006 View in Reaxys 2126/3247 Br

NH 2

F

F

F

F

O

Br

NH

Rx-ID: 36258740 View in Reaxys 2127/3247 Br

F I

Br

H 2N

F

F

F

O

NH

Rx-ID: 36258758 View in Reaxys 2128/3247 Br Si

F

F

F

Br

H 2N

O

F

NH

Rx-ID: 36258777 View in Reaxys 2129/3247 Br

F

F

NH

F

O

F

NH

Rx-ID: 36259402 View in Reaxys 2130/3247 Br

F

F

HN

F

O

F

NH

Rx-ID: 36259424 View in Reaxys 2131/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

265/428

2016-08-04 14:49:45


Br

Br

F

F

F

F

O

NH

NH

Rx-ID: 36259448 View in Reaxys 2132/3247 Br

Br F

F

F

N+

F

Cl –

O

NH

NH

Rx-ID: 36259512 View in Reaxys 2133/3247 Br

Br F

F

F

N

F

O O

NH

NH

Rx-ID: 36394386 View in Reaxys 2134/3247 O

O

O

N

O

O

O

O

NH

N H

O

NH

N H

Rx-ID: 23047558 View in Reaxys 2135/3247

NH 2

N

O

O O

Rx-ID: 5834727 View in Reaxys 2136/3247 O NH 2

NH

Hal-(CH2)3CONH2

O

N

O

O O

Rx-ID: 9443476 View in Reaxys 2137/3247 O

NH N

Cl

O

O N

O

O

O

N

Rx-ID: 28940522 View in Reaxys 2138/3247 O

N

O

O

NH 2

O

N

N O

O

O

O

Rx-ID: 29097426 View in Reaxys 2139/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

266/428

2016-08-04 14:49:45


N

O

OH O

N

O

O

O

O

O

O N

N

Rx-ID: 34515744 View in Reaxys 2140/3247

N

NH

O

O

O

OH N

Rx-ID: 34515809 View in Reaxys 2141/3247

N

N O

O

O

O

O

N

NH

Rx-ID: 34516316 View in Reaxys 2142/3247

N O

O

O

N

Rx-ID: 36393358 View in Reaxys 2143/3247

N

O O

O N

Rx-ID: 36393436 View in Reaxys 2144/3247 O H N

O

NH

O

Rx-ID: 41894210 View in Reaxys 2145/3247

N O NH 2

O

Rx-ID: 5831251 View in Reaxys 2146/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

267/428

2016-08-04 14:49:45


N O O

NH 2

Rx-ID: 5831252 View in Reaxys 2147/3247 Cl

O

N

N H

N

O

N

O O

Rx-ID: 29216493 View in Reaxys 2148/3247 O

N

N

N H

O

N O

Cl

O

Rx-ID: 29415453 View in Reaxys 2149/3247

NH

NH

NH

NH

NH

O

N O

OH

OH

Rx-ID: 1789342 View in Reaxys 2150/3247 O NH O

O N

N

Cl

O

N N

O

O

N O

O

Rx-ID: 3834544 View in Reaxys 2151/3247 O O

O

O

N

O

NH

O

N

N

N

N

Cl O

O

Rx-ID: 9184762 View in Reaxys 2152/3247

NH

O

O

O

NH

N

O

O

O

O O

Rx-ID: 2035648 View in Reaxys 2153/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

268/428

2016-08-04 14:49:45


O O

NH

O

O

O

O

Br

N

O O

Rx-ID: 4925550 View in Reaxys 2154/3247

O

N

OH

O O

Rx-ID: 5834728 View in Reaxys 2155/3247

O

NH

O

O

O

O

NH

N

O

O O

Rx-ID: 8952445 View in Reaxys 2156/3247

O

O O

O

NH

O

O

O N

OH

O OH

O

Rx-ID: 9069174 View in Reaxys 2157/3247 OH O

NH

Hal-(CH2)3CO2H

O

N

O

O O

Rx-ID: 9443474 View in Reaxys 2158/3247 O N

O

O

N O

O

O

O N

O

Rx-ID: 11083720 View in Reaxys 2159/3247

NH O

O

O

O N

OH

O

Rx-ID: 14730122 View in Reaxys 2160/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

269/428

2016-08-04 14:49:45


O

O

O

O

O

O

N

O

O HN

HN

Rx-ID: 24789471 View in Reaxys 2161/3247

O NH

O

O

N

OH

O O

Rx-ID: 30723348 View in Reaxys 2162/3247

NH

O

O

O

N O

O O

Rx-ID: 30723386 View in Reaxys 2163/3247

O

NH

methoxymethyl halide

O

methyl halide

O

O O

N

O O

Rx-ID: 30723399 View in Reaxys 2164/3247 O

NH

OH

O

O

O

O

NH

O

Rx-ID: 39599348 View in Reaxys 2165/3247 O

NH

OH

O

O

O

O

NH

O

Rx-ID: 39599349 View in Reaxys 2166/3247 O O

O

O

N NH

O

O

O

NH

O

Rx-ID: 39599372 View in Reaxys 2167/3247 O O

O

O

N NH

O

O

O

NH

O

Rx-ID: 39599374 View in Reaxys 2168/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

270/428

2016-08-04 14:49:45


O

O

NH

O O

N

Br O O

Rx-ID: 8742266 View in Reaxys 2169/3247

O

N

O

N

N

O

O

O Br

O

Rx-ID: 9539041 View in Reaxys 2170/3247

O

N

N

O

O Br

O

Rx-ID: 13869977 View in Reaxys 2171/3247

Si

Si

N

O

O

O

N

N

O

Rx-ID: 4735773 View in Reaxys 2172/3247

Si

OH N

O

O

N

O

Rx-ID: 17241115 View in Reaxys 2173/3247

Si O

Si

N

HO

O

Rx-ID: 17242709 View in Reaxys 2174/3247

Si

Si O

O

N

N O

O

Rx-ID: 17263360 View in Reaxys 2175/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

271/428

2016-08-04 14:49:45


O

O

O Cl

Cl

N

Cl N

N

N

O

Rx-ID: 28783478 View in Reaxys 2176/3247 O

Cl

NH

N

Cl

Br

O

Rx-ID: 28783486 View in Reaxys 2177/3247 O

NH

Br

N

Cl

Cl

O

Rx-ID: 28783488 View in Reaxys 2178/3247 O NH Br

Br

Br N

O

Rx-ID: 28628843 View in Reaxys 2179/3247

O

NH O

O

N O

O

Rx-ID: 5625496 View in Reaxys 2180/3247

N O O

N

O

O

Rx-ID: 5625399 View in Reaxys 2181/3247

N O O

N

O

O

Rx-ID: 6617322 View in Reaxys 2182/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

272/428

2016-08-04 14:49:45


N O O

N

O

O

Rx-ID: 6668436 View in Reaxys 2183/3247

OH

N O NH 2

O

Rx-ID: 5832813 View in Reaxys 2184/3247 OH

N O O

NH 2

Rx-ID: 5832814 View in Reaxys 2185/3247

N

Cl

Cl

H

N

H N

S

HN

NH S

N O

Rx-ID: 5280260 View in Reaxys 2186/3247 Cl

Cl O

Cl

O N

Cl

N

Cl

Rx-ID: 24580781 View in Reaxys 2187/3247 O O

N O

NH

O

O

O

O

O

NH

O

O

Rx-ID: 28394203 View in Reaxys 2188/3247

NH

O

O

O

F

O

O

O

O

O N

F O

Rx-ID: 10606997 View in Reaxys 2189/3247

NH

O F

O

O

O

O

F

O

O

N O

O

Rx-ID: 10607016 View in Reaxys 2190/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

273/428

2016-08-04 14:49:45


F

NH

O

N

F

O

O

Rx-ID: 30385066 View in Reaxys 2191/3247 O

F

NH

O

O

N O

O

O

O

F

O

O

Rx-ID: 31768167 View in Reaxys 2192/3247

O

NH

O N

F O

Rx-ID: 41493385 View in Reaxys 2193/3247

N

NH

O

S

S

S

NH

O

NH

O

O

O

O O

O

O

Rx-ID: 3345960 View in Reaxys 2194/3247 O

N Cl

O

HS

N S

O

O

O

O

Rx-ID: 10135929 View in Reaxys 2195/3247

O N Cl

O

Rx-ID: 6603473 View in Reaxys 2196/3247

N Cl

O

Rx-ID: 5608720 View in Reaxys 2197/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

274/428

2016-08-04 14:49:45


O NH

Br

Br

Br

N

O

Rx-ID: 28628842 View in Reaxys 2198/3247 F

N O NH 2

O

Rx-ID: 5832815 View in Reaxys 2199/3247

O

NH

O S Cl

N

S O

O

O

O

Rx-ID: 30088250 View in Reaxys 2200/3247 Cl

Cl N

O

N

O

N

O O

O O

Rx-ID: 2774274 View in Reaxys 2201/3247

O

NH Cl

C2H5OCOCH2-halide

O

N

Cl

O O

Rx-ID: 8485482 View in Reaxys 2202/3247 Cl

Cl NH

O

N

O

O

O O

Rx-ID: 21858850 View in Reaxys 2203/3247

Cl

Cl NH

O

N

O

O

O O

Rx-ID: 41104808 View in Reaxys 2204/3247

Cl

Cl

O

NH

N

I

O

O O

O

O

Rx-ID: 41104827 View in Reaxys 2205/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

275/428

2016-08-04 14:49:45


N Cl

O O

Rx-ID: 6605197 View in Reaxys 2206/3247 Cl NH

O

N

Cl

Br

O O

O

Rx-ID: 24124152 View in Reaxys 2207/3247 O N

O

Cl

Rx-ID: 28907232 View in Reaxys 2208/3247 O NH

N

Cl

O

Br O

Cl

O

Rx-ID: 29415470 View in Reaxys 2209/3247

O O

O

N

O

N

Br O

Br O

Rx-ID: 2388204 View in Reaxys 2210/3247 Br O

NH

O

Rx-ID: 6598183 View in Reaxys 2211/3247

O

O

O

NH

O

Br

N Br

O

O

Rx-ID: 25753107 View in Reaxys 2212/3247

O NH

O

Br O

O

O

N Br O

Rx-ID: 27990470 View in Reaxys 2213/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

276/428

2016-08-04 14:49:45


N

N

Br

O O

N

Br

Rx-ID: 28441427 View in Reaxys 2214/3247 O

NH

Br

N

Br

O Br

Rx-ID: 30503436 View in Reaxys 2215/3247 Br

O NH

I

N Br

O

Rx-ID: 32140533 View in Reaxys 2216/3247

NH

I

N

Br

Br

O

O

Rx-ID: 32643623 View in Reaxys 2217/3247 Br

O

O HN

I

N

Br

Rx-ID: 38930874 View in Reaxys 2218/3247

NH

O O

S O

N

O S

N O

N

O

S O

O

O

O

Rx-ID: 3545193 View in Reaxys 2219/3247

NH

N N S O

O

O

O

Rx-ID: 21936994 View in Reaxys 2220/3247

NH

N

Cl

N

S O

S

O

O

O

O

O

Rx-ID: 21950933 View in Reaxys 2221/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

277/428

2016-08-04 14:49:45


O Cl O

NH Cl

K2O3olution

(2-methyloxyethyl)oxymethylchlorid

O

N

O

Rx-ID: 22846057 View in Reaxys 2222/3247 O Cl

O

O

2 O

–O

Cl

O

NH

K+

Cl

O

N

O–

O

Rx-ID: 24573393 View in Reaxys 2223/3247 O

HN N

S

S

Cl

O

Rx-ID: 24141542 View in Reaxys 2224/3247

Br

O

NH

Br

O

N

Cl

O O

Rx-ID: 2856871 View in Reaxys 2225/3247

O

NH N

O

Br

Cl Br

O

O

Rx-ID: 4609082 View in Reaxys 2226/3247 Br OH

NH

O

Rx-ID: 6596377 View in Reaxys 2227/3247

O

NH

N

Br

O

Br

Cl

O

O

Rx-ID: 9966593 View in Reaxys 2228/3247 Br

O

Br

O

O

O

I NH

N

Rx-ID: 10552194 View in Reaxys 2229/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

278/428

2016-08-04 14:49:45


O

Br NH

O

O

N Br

Rx-ID: 11780072 View in Reaxys 2230/3247 O NH O

O

O

N N

N

O

O

O

S

Rx-ID: 41754842 View in Reaxys 2231/3247 O NH O

O

O

O

N

S Cl

N O

N

O

O

O

S

O

Rx-ID: 41754947 View in Reaxys 2232/3247

NH Cl O O

N

O

O

Rx-ID: 6619920 View in Reaxys 2233/3247 Br

N O

NH

O

O

Rx-ID: 25784682 View in Reaxys 2234/3247 O O

O

OH

N

N

O

O

N

NH O

O

Br NH

N O

O

Rx-ID: 28628851 View in Reaxys 2235/3247 O NH O

O

N

O

O

O

N

N

Br NH

O

Rx-ID: 29792408 View in Reaxys 2236/3247

N

N

O

E

O

Rx-ID: 10278847 View in Reaxys 2237/3247

N

NH

O

E

O

Rx-ID: 12361659 View in Reaxys 2238/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

279/428

2016-08-04 14:49:45


NH

NH

O

N

N

O

O

F

F

O

N F

F

F

F

Rx-ID: 3345211 View in Reaxys 2239/3247

NH NH

O NH 2

O

N F

F F

Rx-ID: 19588022 View in Reaxys 2240/3247

NH

NH

O

NH

O

F

F

O

N F

F

F

F

Rx-ID: 19608481 View in Reaxys 2241/3247 O

N

O

O O

NH N

O

O

N

O

O

O

Rx-ID: 35518680 View in Reaxys 2242/3247 O N

O

O O

O

NH N

O N

O

O

O

Rx-ID: 35518843 View in Reaxys 2243/3247

NH

NH

N

O I

I

O

Rx-ID: 1643450 View in Reaxys 2244/3247

NH

NH

O

I

O

Rx-ID: 1647450 View in Reaxys 2245/3247

NH

NH

NH

I O

I

O

O

Rx-ID: 1647451 View in Reaxys 2246/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

280/428

2016-08-04 14:49:45


NH

NH

N

O I

I

O

Rx-ID: 1650453 View in Reaxys 2247/3247

NH

F

NH

O

F

O

Tl

O

O

F

F

O F

I

O

F

Rx-ID: 2524931 View in Reaxys 2248/3247

I

N

I

NH

NH

O O

Rx-ID: 4269192 View in Reaxys 2249/3247

NH

I

O

Rx-ID: 6588932 View in Reaxys 2250/3247 I

I

NH

NH

N

O

O

Rx-ID: 9204733 View in Reaxys 2251/3247

NH

NH

N

I

I

O O

Rx-ID: 10222326 View in Reaxys 2252/3247

O H 2N

I

NH

N

O

Rx-ID: 17964417 View in Reaxys 2253/3247

I

I

NH

NH

O

Rx-ID: 17989315 View in Reaxys 2254/3247

O I

I

NH

N

O

Rx-ID: 17989480 View in Reaxys 2255/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

281/428

2016-08-04 14:49:45


O

NH

N I I

O

Rx-ID: 19529104 View in Reaxys 2256/3247

NH

NH I

I

O

Rx-ID: 19547281 View in Reaxys 2257/3247

NH

NH

Br

I

O

O

Rx-ID: 28628837 View in Reaxys 2258/3247

NH

NH HN

I

I

O

Rx-ID: 31402599 View in Reaxys 2259/3247 F F

F S

F

F

F

F

F S

O

F

F NH

NH 2

Rx-ID: 39930887 View in Reaxys 2260/3247 F

F F HN

F S

F

N

F

S

F

O

O

F

F NH

F

Rx-ID: 39930909 View in Reaxys 2261/3247

F F

F

F S

NH 2

F

F S

O

F

F

F F

NH

Rx-ID: 39930936 View in Reaxys 2262/3247 Br F F

F

F

F

S

NH 2

F S

O

F

F NH

F F

Rx-ID: 39930943 View in Reaxys 2263/3247 F F

F S

F F

F F

F S

O

F

F NH

NH 2

Si

Rx-ID: 39930949 View in Reaxys 2264/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

282/428

2016-08-04 14:49:45


O

N

O

N

Br O

O O

O

Rx-ID: 29626288 View in Reaxys 2265/3247 O O

F

F B–

O

K+

N

N

F

Cl

O

O

O

Rx-ID: 32896578 View in Reaxys 2266/3247 O O

O

O O

O

O

NH

O

O

E

NH

NH

Z

O

Rx-ID: 36422601 View in Reaxys 2267/3247

O

OH

N

N

E

O

O O

Rx-ID: 37062062 View in Reaxys 2268/3247

O

O

N

N

P

O O

E

O

O O

Rx-ID: 37062079 View in Reaxys 2269/3247

O NH

N

O

E O O

Rx-ID: 37062101 View in Reaxys 2270/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

283/428

2016-08-04 14:49:45


O

NH

N

E O O

Rx-ID: 37062114 View in Reaxys 2271/3247 O O

Sn

O

N

N

O I

O

O

Rx-ID: 38205028 View in Reaxys 2272/3247 O

NH

N O

O

O

Rx-ID: 38205035 View in Reaxys 2273/3247 O

NH

N I

O

O

O

Rx-ID: 38205048 View in Reaxys 2274/3247

O O

O N

N O

O O

O

Rx-ID: 41432864 View in Reaxys 2275/3247 OH

O

N O

N

O O

O

Rx-ID: 41432869 View in Reaxys 2276/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

284/428

2016-08-04 14:49:45


O

Si

O

N

N O

O

O

O

Rx-ID: 41432890 View in Reaxys 2277/3247 O

OH

N

N O

O

O

O

Rx-ID: 41432907 View in Reaxys 2278/3247 O

O

N

N

O

O

O

O

Rx-ID: 41432916 View in Reaxys 2279/3247 F

O O

S O

F

O

F

N

N O

O

O

O

Rx-ID: 41432934 View in Reaxys 2280/3247

NH NH

N

NH

O

N+ O

C–

N

O

Z O

O

N

O

Rx-ID: 1560398 View in Reaxys 2281/3247

O NH

N

Cl

O

O

O

Rx-ID: 8526990 View in Reaxys 2282/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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2016-08-04 14:49:45


O

O

N

O

N

N

O

Rx-ID: 8699452 View in Reaxys 2283/3247 O

N

Rx-ID: 24946947 View in Reaxys 2284/3247

Si

N

N

Si

O

O

Rx-ID: 8867342 View in Reaxys 2285/3247 O

O E E N

N

O

Si

Si

Z

N

N

Rx-ID: 35447324 View in Reaxys 2286/3247 O

O N

E O

Si

Si

Z

N

N

Rx-ID: 35447381 View in Reaxys 2287/3247 O

O

O E

Si

Si

Z

EN N

Si

N

N

Rx-ID: 35447416 View in Reaxys 2288/3247 O

O Si

N E

E

Si

N

N

Rx-ID: 39436665 View in Reaxys 2289/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

286/428

2016-08-04 14:49:45


O O E

EN E

Si

N

Si

N

Rx-ID: 39436686 View in Reaxys 2290/3247 O O

O

O

N

HN

O

Br HN

F

F

Rx-ID: 29581742 View in Reaxys 2291/3247 O

O NH

N H

N

NH

N H

O

O

Rx-ID: 3345200 View in Reaxys 2292/3247

O

NH

N

HN

N

N OH

HO O

NH

NH

N

NH

Rx-ID: 26009903 View in Reaxys 2293/3247

N O

N

N

O

O

O

N

N

O N O

O

O

Rx-ID: 3741536 View in Reaxys 2294/3247

NH O

N

N O

N O

N O

O

Rx-ID: 21027000 View in Reaxys 2295/3247

NH O

O

N O

N

N

O

N O

O

Rx-ID: 21027026 View in Reaxys 2296/3247 O

NH O

O N

N O

O

O

N

O

N

E N

O

Rx-ID: 23398930 View in Reaxys 2297/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

287/428

2016-08-04 14:49:45


N

O

O

O

Rx-ID: 6670324 View in Reaxys 2298/3247

NH

O

O

NH

N O

O

O

O

Rx-ID: 9543142 View in Reaxys 2299/3247 O

O

O

N

Br

N O

O

O

Rx-ID: 24794282 View in Reaxys 2300/3247 O

O

NH

Br

N O

O

O

O

Rx-ID: 29535928 View in Reaxys 2301/3247 O

N

NH

O

Br O

O

O O

Rx-ID: 39002196 View in Reaxys 2302/3247

O

NH O

O

O

O

N

O

O

O O

Rx-ID: 42319524 View in Reaxys 2303/3247

O

O

NH

N

O

Rx-ID: 42319528 View in Reaxys 2304/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

288/428

2016-08-04 14:49:45


N

NH

O

O O

Rx-ID: 5617779 View in Reaxys 2305/3247

O

O

O

O O

N H

NH

O

O

NH

N H

O

Rx-ID: 24143248 View in Reaxys 2306/3247 O N N

O

O

Rx-ID: 28907172 View in Reaxys 2307/3247 O

O

NH

O

N

Cl N

O

Rx-ID: 34515882 View in Reaxys 2308/3247 O

NH

O N

N

O

NH

O

O N

O

Rx-ID: 34515957 View in Reaxys 2309/3247 O

HO

NH

NH

O N

O

Rx-ID: 34516158 View in Reaxys 2310/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

289/428

2016-08-04 14:49:45


O

NH

O N

O

Rx-ID: 36393348 View in Reaxys 2311/3247

NH

O

H N

O O

H 2N

NH

Rx-ID: 39599314 View in Reaxys 2312/3247 H N

O

N

O

O

H N

O

O O

NH

NH

Rx-ID: 39599324 View in Reaxys 2313/3247 O

NH

O

H 2N

O N H NH

Rx-ID: 39599329 View in Reaxys 2314/3247 O O

O

N H

N

O

O

O N H NH

NH

Rx-ID: 39599334 View in Reaxys 2315/3247

O

O

O

O

O

O

H N

O O

NH

Rx-ID: 39599413 View in Reaxys 2316/3247 O

O

O

O

O O

O

O

N H NH

Rx-ID: 39599414 View in Reaxys 2317/3247

O O

Br

O

N N

Rx-ID: 42652144 View in Reaxys 2318/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

290/428

2016-08-04 14:49:45


O

O O

NH O

N N

N O

Rx-ID: 42652151 View in Reaxys 2319/3247 O N

O

O O

O

N

N

N N

O

Rx-ID: 42652162 View in Reaxys 2320/3247

N O O

NH 2

Rx-ID: 5832011 View in Reaxys 2321/3247

N

O

N

O

Rx-ID: 28907236 View in Reaxys 2322/3247

O N

N

O

N

N H O

Cl

O

Rx-ID: 29415454 View in Reaxys 2323/3247

N

O OH

O

N

N

N

N

O

O O

O

N

N

O

O

O N

OH

OH

Rx-ID: 1812150 View in Reaxys 2324/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

291/428

2016-08-04 14:49:45


N

N

N

N

N

O

O

O O

O

OH

OH

N

Rx-ID: 1812151 View in Reaxys 2325/3247

O

N

N

N

O

N

N

O

O O

OH

OH

N

Rx-ID: 1812152 View in Reaxys 2326/3247

N

N

N

N

N

O

O

O

O O

OH

N

OH

OH

Rx-ID: 1812153 View in Reaxys 2327/3247 O

O

O

O

N

O

O

O

NH

O

NH

O

O

Na

O

O

O

O

Rx-ID: 1796361 View in Reaxys 2328/3247 O

O

O N

O

O O

O

NH

O

NH

O

O

O

O

O

O

Rx-ID: 4896764 View in Reaxys 2329/3247 O O

NH

NH

O O O

Rx-ID: 15540660 View in Reaxys 2330/3247 O

O

O

NH

N

O O O

Rx-ID: 15541430 View in Reaxys 2331/3247

O O

NH

O

Br

O

O

N

O O

O

Rx-ID: 2921929 View in Reaxys 2332/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

292/428

2016-08-04 14:49:45


O N

N

O

N

O O

O

O O

O

Rx-ID: 3345745 View in Reaxys 2333/3247

O

N

O

O O

Rx-ID: 5833582 View in Reaxys 2334/3247

NH

O N

O

O

O

O

O

O

O

O

O O

Rx-ID: 8744516 View in Reaxys 2335/3247 O

OH

NH

Hal-(CH2)4CO2H

O

N

O

O O

Rx-ID: 9443480 View in Reaxys 2336/3247

O

NH O

O

O

O

O O

O

O

N

O O

Rx-ID: 9771077 View in Reaxys 2337/3247 O NH

O O

O

O

N O O

Rx-ID: 18831955 View in Reaxys 2338/3247 O

N OH

O

O

N O O

Rx-ID: 18841040 View in Reaxys 2339/3247 O N O

O O

O

N O O

Rx-ID: 18842662 View in Reaxys 2340/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

293/428

2016-08-04 14:49:45


O O

NH

O

O

N

O

Rx-ID: 19527710 View in Reaxys 2341/3247 O O NH

O

Br O

N

O

O O

O

Rx-ID: 29147706 View in Reaxys 2342/3247

O

O

NH N O

O

Rx-ID: 34994166 View in Reaxys 2343/3247

O

O

NH N O

O

O

Rx-ID: 34994214 View in Reaxys 2344/3247

O

O

NH

O

N

O

O

O

O

O

O

Rx-ID: 34994232 View in Reaxys 2345/3247

O

O

O O

O

NH N

O

O

O

O

O

O

Rx-ID: 35519002 View in Reaxys 2346/3247 O O

O

NH

NH OH

O O

Rx-ID: 39599283 View in Reaxys 2347/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

294/428

2016-08-04 14:49:45


O NH

O

OH

NH

O

O

O O

Rx-ID: 39599355 View in Reaxys 2348/3247 O NH

O

O

NH

O

O

O O

Rx-ID: 39599370 View in Reaxys 2349/3247 O NH

O

OH

NH

O

O O

Rx-ID: 39599387 View in Reaxys 2350/3247 O NH

O

O

NH

O

O O

Rx-ID: 39599396 View in Reaxys 2351/3247 O

O

O

O

O

NH

NH

O O

Rx-ID: 39599400 View in Reaxys 2352/3247 O O

O OH

NH

NH

O O

Rx-ID: 39599402 View in Reaxys 2353/3247 O O

O NH

N

O

O

NH

O

O O

Rx-ID: 39599405 View in Reaxys 2354/3247

O

O

NH N

O

O

O

Rx-ID: 41493387 View in Reaxys 2355/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

295/428

2016-08-04 14:49:45


O

N

NH 2

O NH 2

O

Rx-ID: 5837143 View in Reaxys 2356/3247

Si

NH O

Si Cl

O

N

O O

Rx-ID: 4607602 View in Reaxys 2357/3247

Si

NH

O N

O

Rx-ID: 34489316 View in Reaxys 2358/3247

OH

N

O

N O

O O

N

O

O

O

N

O

O

Rx-ID: 3615176 View in Reaxys 2359/3247 O

N

O

O

NH

O

O

Rx-ID: 6863822 View in Reaxys 2360/3247

N O O

N

O

O

Rx-ID: 6669160 View in Reaxys 2361/3247 O

N

O

NH 2

O

O

O N

O

O

O N

O

O

Rx-ID: 11083722 View in Reaxys 2362/3247 NH 2

O O

O N

O

O

O

O N

O

Rx-ID: 11548841 View in Reaxys 2363/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

296/428

2016-08-04 14:49:45


NH 2

O

O

O

O

O

O

N

N

O

Rx-ID: 11564500 View in Reaxys 2364/3247 O O

NH

F

O O S

F

F

O S

O

F

O

F

N O

F

F

S

F

O

F

Rx-ID: 41755057 View in Reaxys 2365/3247

O

NH

O

O

NH

O

N O

O

O

O

O O

Rx-ID: 4769668 View in Reaxys 2366/3247

O

O

N

N

O

O O

O

O

OH

Rx-ID: 38777400 View in Reaxys 2367/3247

O

N NH

O

O

OH

Rx-ID: 38777402 View in Reaxys 2368/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

297/428

2016-08-04 14:49:45


O

N NH

O O

O

OH

Rx-ID: 38777405 View in Reaxys 2369/3247

O

N

HO

O

OH

O

O

O

OH

Rx-ID: 39200925 View in Reaxys 2370/3247

O

N

HO O

O

O

O

O

OH

Rx-ID: 39200934 View in Reaxys 2371/3247

O

N O

O O O

O Br

OH

Rx-ID: 39200936 View in Reaxys 2372/3247

O

O O N

O N

Cl

O

SH

O

Rx-ID: 10235087 View in Reaxys 2373/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

298/428

2016-08-04 14:49:45


NH N

Br

Br

Br

O O

Rx-ID: 4666333 View in Reaxys 2374/3247 O O

O

NH

O

N

O

O

NH

O

O

O

O

Rx-ID: 8970254 View in Reaxys 2375/3247 O O

O

NH

O

N

O

O

NH

O

O O

Rx-ID: 15051029 View in Reaxys 2376/3247

O

N

OH

N

O

O O

N

O

O

O

N

O

O

Rx-ID: 3615039 View in Reaxys 2377/3247 O O

N

OH

N

O

O O

N

O

O

O

N

O

O

Rx-ID: 3617471 View in Reaxys 2378/3247

N N Cl

O

Rx-ID: 5831253 View in Reaxys 2379/3247

NH

Z O

O OH

NH

O

HO

H O

H

O

O O

H

O

HO

OH

N H

O O

O O

Rx-ID: 9366292 View in Reaxys 2380/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

299/428

2016-08-04 14:49:45


NH O

NH

O

Z H

O

H

O

O

H

O

O

OH

HO NH

O

HO

O

OH

O

O

O

Rx-ID: 9366293 View in Reaxys 2381/3247

O

O

O

Cl

O

O

O

O

NH

N Cl

O O

Rx-ID: 8899757 View in Reaxys 2382/3247

NH

O

O

O

Cl

O

O

O

O

O N

Cl O

Rx-ID: 10607012 View in Reaxys 2383/3247 O

Cl

NH

O

O

O

O

O

N

Cl

O

O

O

Rx-ID: 28629632 View in Reaxys 2384/3247

Cl

NH

Cl

O

O

N

O

O

O

O

O

O

O

Rx-ID: 35518573 View in Reaxys 2385/3247 O

Cl

O

O

NH

O

O

N

O Cl

O

O

O

Rx-ID: 35518656 View in Reaxys 2386/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

300/428

2016-08-04 14:49:45


O

Cl

NH

N

Cl

O

O

Rx-ID: 36612595 View in Reaxys 2387/3247

Cl

NH

Cl

O

N

Br

O O O

Rx-ID: 24124156 View in Reaxys 2388/3247 O

S Cl

N

NH

O

S NH

Cl

Rx-ID: 39257846 View in Reaxys 2389/3247 O Br

NH N

Rx-ID: 32945880 View in Reaxys 2390/3247 O Br

NH N

Br

Rx-ID: 32945917 View in Reaxys 2391/3247 O Br

NH

n-butyl halide

Br

N

O

Rx-ID: 32945953 View in Reaxys 2392/3247 O

O S NH

Br

O O–

Na +

N

Rx-ID: 32945957 View in Reaxys 2393/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

301/428

2016-08-04 14:49:45


O Br

O

O

S

+ O– Na

N

N

O

Rx-ID: 32945967 View in Reaxys 2394/3247 O Br

NH

butyl halide

Br

N

O

Rx-ID: 36255902 View in Reaxys 2395/3247 O

NH

N

Br

Br

O Br

Rx-ID: 36492800 View in Reaxys 2396/3247

NH

N

I

N

N

S O

S O

O

O

O

O

Rx-ID: 2852566 View in Reaxys 2397/3247

NH

NH

Cl S O

N

N H

O

S O

O

O

O

Rx-ID: 3303008 View in Reaxys 2398/3247

NH

NH N S O

O

O

O

Rx-ID: 21936995 View in Reaxys 2399/3247

NH

N N S O

O

O

O

Rx-ID: 21936996 View in Reaxys 2400/3247

NH

N

Cl

N

S O

S

O

O

O

O

O

Rx-ID: 21950934 View in Reaxys 2401/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

302/428

2016-08-04 14:49:45


Cl

N O O

NH 2

Rx-ID: 5832816 View in Reaxys 2402/3247

O

NH

O

O

Cl P

O

P

O

N

O

O O

Rx-ID: 1647321 View in Reaxys 2403/3247

O

N O

O

Cl P

O

O

N

Z

O

P

N O

Rx-ID: 2721673 View in Reaxys 2404/3247

O

NH

O

O

Cl P

O

P

N

O

N

O

O

O O

Rx-ID: 33609193 View in Reaxys 2405/3247 O NH

O

O

O

S

O

Cl

O

O

N

O

O

S

O

Rx-ID: 41754961 View in Reaxys 2406/3247

O

OH NH

O

O

O NH

O

Rx-ID: 24268181 View in Reaxys 2407/3247

O N H

Rx-ID: 6664483 View in Reaxys 2408/3247

NH

NH Br O

Rx-ID: 30444255 View in Reaxys 2409/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

303/428

2016-08-04 14:49:45


NH

NH

O

Rx-ID: 30444266 View in Reaxys 2410/3247

NH

NH

Cl

O

Rx-ID: 30444273 View in Reaxys 2411/3247

NH

NH

N

O

O

Rx-ID: 30444279 View in Reaxys 2412/3247

NH

NH

O

Rx-ID: 30444282 View in Reaxys 2413/3247

NH

O

Rx-ID: 30444290 View in Reaxys 2414/3247

NH

B

O

Rx-ID: 30444320 View in Reaxys 2415/3247 O O

NH

O

O

O

O

Br

N

O Br

O

O

Rx-ID: 1720611 View in Reaxys 2416/3247 O O

NH Br

N Br O

Rx-ID: 18689219 View in Reaxys 2417/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

304/428

2016-08-04 14:49:45


O

O

O

Br

N

O

O

Br

O

NH

NH

Rx-ID: 23047555 View in Reaxys 2418/3247 Br

O O

NH

N

O

O O

O

HN

Br

Rx-ID: 28017076 View in Reaxys 2419/3247 O

O O

Br

O Br

OH NH

OH

OH

NH

O

Rx-ID: 37929287 View in Reaxys 2420/3247 O

O O

Br

O Br

O NH

OH

O

NH

O

Rx-ID: 37929308 View in Reaxys 2421/3247 Br

O

O O

N

O

NH

Br O

HO

O

Rx-ID: 39386226 View in Reaxys 2422/3247 Br

O

O Br OH

NH

NH O

O

Rx-ID: 39386454 View in Reaxys 2423/3247 Br

Br

NH O

N

O

O

NH

O

O

O

Rx-ID: 39386525 View in Reaxys 2424/3247

Br

Br

N

N O

N

O O O

Rx-ID: 3344976 View in Reaxys 2425/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

305/428

2016-08-04 14:49:45


Br

N

Br

O

O

O

O

N

O

Rx-ID: 19773550 View in Reaxys 2426/3247

Br

N

Br

O

N

O OH

O

O

Rx-ID: 19778082 View in Reaxys 2427/3247

NH

N

N

N

N

NH

N

NH

NH O

N

O

OH

N

Rx-ID: 4453185 View in Reaxys 2428/3247

N Cl O N

O

O

O

Rx-ID: 6621255 View in Reaxys 2429/3247

F

F

F

F

O

F

O

F N

N

Rx-ID: 38895599 View in Reaxys 2430/3247

N

N

O

I

O

Rx-ID: 1704195 View in Reaxys 2431/3247

N

I

O

Rx-ID: 6590461 View in Reaxys 2432/3247

NH

I

O

Rx-ID: 6590610 View in Reaxys 2433/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

306/428

2016-08-04 14:49:45


O

F

NH

S

2 Na +– O

S

O

O–

NH

F

3 –O

O

Tl3+

F

O

O

I

O

Rx-ID: 24213744 View in Reaxys 2434/3247 O N

N

I

O

I N

Rx-ID: 31071226 View in Reaxys 2435/3247 O

N I N

O

Rx-ID: 35228295 View in Reaxys 2436/3247 O

O (v2)

C–

Zn 2+(v4) – N (v4) C

I

N

N

O

Rx-ID: 35228296 View in Reaxys 2437/3247

NH

NH

O

I

O

Rx-ID: 38205047 View in Reaxys 2438/3247 F

F F

N

F

F O

NH

O

F O

NH

O

O O

Rx-ID: 3345969 View in Reaxys 2439/3247 O

F F

O O

N

N

F

F

F

O

NH

F O O

Rx-ID: 18496614 View in Reaxys 2440/3247 F F

O O

EN

N H

F O

NH

F

O

F F

O

Rx-ID: 18506080 View in Reaxys 2441/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

307/428

2016-08-04 14:49:45


F F

H 2N F

F O

NH

F

O

F O

Rx-ID: 18509087 View in Reaxys 2442/3247 O

O

O

O

N

E

E

O

NH

NH

O

Rx-ID: 5335179 View in Reaxys 2443/3247 O O

E

NH NH

O

Rx-ID: 16005822 View in Reaxys 2444/3247 O O O O

E

N

NH

O

Rx-ID: 16015857 View in Reaxys 2445/3247 O O

O O O

E

N

NH

O

Rx-ID: 16023613 View in Reaxys 2446/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

308/428

2016-08-04 14:49:45


O

O O

O

E

E

NH

NH

O

Rx-ID: 16025471 View in Reaxys 2447/3247 O O

O

HO

O

E

N NH

O

Rx-ID: 16027381 View in Reaxys 2448/3247 O

O O

O

E

E

O O NH

N

O

Rx-ID: 16030219 View in Reaxys 2449/3247 O O

O O

O O

NH

O

NH

O O

E

NH

Z

O

Rx-ID: 36422602 View in Reaxys 2450/3247 HO O

N N O E

O

O

Rx-ID: 37062056 View in Reaxys 2451/3247

O

O N

O

P

N O E

O

O O

Rx-ID: 37062074 View in Reaxys 2452/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

309/428

2016-08-04 14:49:45


O

NH

N O

O

E O

Rx-ID: 37062100 View in Reaxys 2453/3247

O

NH

N O E O

Rx-ID: 37062113 View in Reaxys 2454/3247

O O

O N

Sn

N O

I

O

O

Rx-ID: 38205026 View in Reaxys 2455/3247

O

NH N

O

O

O

Rx-ID: 38205036 View in Reaxys 2456/3247

O

NH N

I

O

O

O

Rx-ID: 38205049 View in Reaxys 2457/3247 O O

O

N

N

N

O

Rx-ID: 34827512 View in Reaxys 2458/3247 O O N I

Rx-ID: 34827513 View in Reaxys 2459/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

310/428

2016-08-04 14:49:45


O O

NH

N

O

Rx-ID: 34827517 View in Reaxys 2460/3247

Cl

Cl

O

NH

O

NH

N O

O

O

Cl

Cl

O

Rx-ID: 4616250 View in Reaxys 2461/3247

Cl

Cl

O

NH

N

O

NH

O

O

O

Cl

Cl

O

Rx-ID: 8813034 View in Reaxys 2462/3247

Cl

Cl

O

NH

O

NH

O

O

Cl

Cl

O

Rx-ID: 24590941 View in Reaxys 2463/3247 O

Cl NH

Cl

O

N

O

O NH

O

Cl

O

Cl

Rx-ID: 28233201 View in Reaxys 2464/3247 Cl Cl

O N

O

N H

O

NH

O

Cl Cl

O

Rx-ID: 32183379 View in Reaxys 2465/3247

H 2N

H N

Cl

Cl

Cl

O

NH

H

O

Cl

Cl

O

Rx-ID: 36651428 View in Reaxys 2466/3247 Cl

Cl

Cl

O

NH

O

NH 2

Cl

O

Rx-ID: 37712141 View in Reaxys 2467/3247

O

E

N

H N

Cl

Cl

O

NH

O

O

Cl

Cl

O

Rx-ID: 42064118 View in Reaxys 2468/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

311/428

2016-08-04 14:49:45


O

NH NH

O

Rx-ID: 24868719 View in Reaxys 2469/3247 O

NH Cl

I

N

Cl Br

Br

O

Rx-ID: 28907706 View in Reaxys 2470/3247 O O

F F N

F

HO

Rx-ID: 28907203 View in Reaxys 2471/3247 O

O

O

O

O

O

N

O O

N

O

E

O

O

O

N

O

E

O O

E O

O

O

N

O

O

Rx-ID: 3353719 View in Reaxys 2472/3247

O

O

O E

Cl NH

O O

E

O

O

N

O

O

O

Rx-ID: 3356855 View in Reaxys 2473/3247 O NH

O

N

Cl O

E O

O O

O

E

O

O

O

Rx-ID: 3356856 View in Reaxys 2474/3247 O NH O

Cl

E O

O O

O

N O

E

O

O

O

Rx-ID: 3356857 View in Reaxys 2475/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

312/428

2016-08-04 14:49:45


O

O

O

O

Z

N

O

Z

O

O

N

O

O

O

N

E O

N

O

O O

Rx-ID: 3419185 View in Reaxys 2476/3247 O

O

N NH

O

E O

O

O

Rx-ID: 20045593 View in Reaxys 2477/3247 O NH

O

N O

E

O

O

O

Rx-ID: 20045596 View in Reaxys 2478/3247

O

O

O O

E

NH

O

N

O

Rx-ID: 20048307 View in Reaxys 2479/3247

O

HO

O O

E

NH

O

N

O

Rx-ID: 20048358 View in Reaxys 2480/3247

O

O E

O

O

O

N O

O

N

O

O

Rx-ID: 20053512 View in Reaxys 2481/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

313/428

2016-08-04 14:49:45


O

O

O

O O

E

NH

O

N

O

Rx-ID: 20057728 View in Reaxys 2482/3247

O

O

O

O O

E

E

O

N

NH

O

Rx-ID: 20064598 View in Reaxys 2483/3247 O

O Z

NH

O

O

N

O O

Rx-ID: 20126050 View in Reaxys 2484/3247

O

O O

NH

E O

N

O O

Rx-ID: 20126051 View in Reaxys 2485/3247

O

O

O

NH

NH

N

O N

O

OH

O

HO

N

O

Rx-ID: 5212042 View in Reaxys 2486/3247

NH O

O

N

O

O

N

N

N

O

O

N O

O

Rx-ID: 3741535 View in Reaxys 2487/3247

O

N O

O

N O

O

N

N

N

O

N O

O

Rx-ID: 3741739 View in Reaxys 2488/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

314/428

2016-08-04 14:49:45


O

N O

N

N O

N

N O

O

N O

O

O

Rx-ID: 3789028 View in Reaxys 2489/3247

NH O

N

N O

N O

N O

O

Rx-ID: 21027001 View in Reaxys 2490/3247

NH O

N

N O

N O

N O

O

Rx-ID: 21027002 View in Reaxys 2491/3247

NH O

O

N O

N

N

O

N O

O

Rx-ID: 21027027 View in Reaxys 2492/3247

NH O

N O

N

N O

O

N O

O

Rx-ID: 21027028 View in Reaxys 2493/3247 N

N

N

N O O

NH 2

Rx-ID: 5840885 View in Reaxys 2494/3247

NH OH

NH

N

O

NH

O

O

O

O

S

O

O

Rx-ID: 1795878 View in Reaxys 2495/3247

NH OH

O

N

O

Cl O

NH

O

NH O

S O

O

S

O

O

Rx-ID: 3427868 View in Reaxys 2496/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

315/428

2016-08-04 14:49:45


O

O

N

NH

O

O

NH

O

O

Rx-ID: 9472694 View in Reaxys 2497/3247 O

O

N OH

NH

O

O

O

O

Rx-ID: 13907261 View in Reaxys 2498/3247 O O

N O

NH

O

O

O

O

Rx-ID: 13907521 View in Reaxys 2499/3247 O

O

NH

O

O NH 2

O

Rx-ID: 13907861 View in Reaxys 2500/3247 O

O I

NH

O

O NH 2

O

Rx-ID: 13925497 View in Reaxys 2501/3247 O

O

NH

O

O NH 2

O

Rx-ID: 13931611 View in Reaxys 2502/3247 O

O NH

O

O

NH

O

Rx-ID: 23500272 View in Reaxys 2503/3247

O

O

O

O

O

O

O

N

O

HN

O

Rx-ID: 42319525 View in Reaxys 2504/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

316/428

2016-08-04 14:49:45


N

OH

O

N

N

N

N

O N

N

O

O

O

Rx-ID: 9633428 View in Reaxys 2505/3247

N

N

N

N

N

OH

O

N

O

O

N

N

O

O

O

Rx-ID: 28628828 View in Reaxys 2506/3247

O NH

HN

O

O O

Rx-ID: 5638262 View in Reaxys 2507/3247

O

O

O

O

N

N

N

N

O

N

NH 2

O

O

O

N N

O

N

O

O

Rx-ID: 2989216 View in Reaxys 2508/3247

O

O

O

N

N

OH

O

O

O

O

O

N

N

Rx-ID: 34515778 View in Reaxys 2509/3247

N

NH

O

O

O

OH

N

Rx-ID: 34515815 View in Reaxys 2510/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

317/428

2016-08-04 14:49:45


O N

N

Cl

O

O

O

N

Rx-ID: 34515880 View in Reaxys 2511/3247 O

O

N

O

N

Cl N

O

Rx-ID: 34515884 View in Reaxys 2512/3247 O

N

O N

N

O

N

O

O N

O

Rx-ID: 34515959 View in Reaxys 2513/3247 O

NH

O N

N

O O

N

O

Rx-ID: 34516034 View in Reaxys 2514/3247 O

HO

NH

N

O N

O

Rx-ID: 34516159 View in Reaxys 2515/3247

N

N O

O

O

NH

O

O

N

Rx-ID: 34516329 View in Reaxys 2516/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

318/428

2016-08-04 14:49:45


O NH

O

NH

N

O O

Rx-ID: 34887982 View in Reaxys 2517/3247

O

O

H N

O

N

O

O

O

HN

O

NH

N

O O

Rx-ID: 35319161 View in Reaxys 2518/3247

N O

O

O

N

Rx-ID: 36393363 View in Reaxys 2519/3247 O

N

O N

O

Rx-ID: 36393437 View in Reaxys 2520/3247 O

O N H

O O

O

N

HN O

N

Rx-ID: 38895592 View in Reaxys 2521/3247 F

NH

N

O

I

O

I

NH

F

Rx-ID: 41310026 View in Reaxys 2522/3247

NH

F

F

O

I NH

Rx-ID: 41310062 View in Reaxys 2523/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

319/428

2016-08-04 14:49:45


O

F

Si

I

N

NH

I F

Rx-ID: 41310076 View in Reaxys 2524/3247

O

F

Si

I

N

NH F

Rx-ID: 41310122 View in Reaxys 2525/3247

O N

O NH

O

O

O

N

O

O

O

O

O

O

Rx-ID: 77737 View in Reaxys 2526/3247

O

NH

O

NH

N

O

O

O

O

O

O O

O

Rx-ID: 8682518 View in Reaxys 2527/3247

N O

O O

O

Rx-ID: 6670133 View in Reaxys 2528/3247

O

NH

O

Hal-(CH2)3CO2Et

O

N

O O O

Rx-ID: 9443473 View in Reaxys 2529/3247

O

NH

Hal-CH2CO2tBu

O O

O

N O O

Rx-ID: 9443487 View in Reaxys 2530/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

320/428

2016-08-04 14:49:45


OH

O

N O

O

Rx-ID: 22820852 View in Reaxys 2531/3247 O O NH

O

O

N

O

O

O

O

O O

O

Rx-ID: 31845030 View in Reaxys 2532/3247 O

NH

O

O

N

O

O

O

O

O

Rx-ID: 33524255 View in Reaxys 2533/3247 O

N

N

N

N

O

O

O

O O

O

Rx-ID: 38026960 View in Reaxys 2534/3247

Si

Si

NH

O O

O

O N

N

O

N

O

Rx-ID: 9122182 View in Reaxys 2535/3247

Si

N

O

O

N

Si O

N

Si O

N

Br

O

Rx-ID: 8699449 View in Reaxys 2536/3247

Si

N

O

Si

Si

N

O

N

N O

O Br

O

Rx-ID: 8699456 View in Reaxys 2537/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

321/428

2016-08-04 14:49:45


O

Si

NH

O

N

O

Rx-ID: 15540871 View in Reaxys 2538/3247

Si NH

N

O

O O

Rx-ID: 15540884 View in Reaxys 2539/3247

Si

hexacarbonyl-μ-[η4-(2R,3R)-2-ethynyl-3-hydroxytetrahydropyran]dicobalt(Co-Co)

Si Cl

O

N

O

Rx-ID: 15552875 View in Reaxys 2540/3247

Si

hexacarbonyl-μ-[η4-(2R,3R)-2-ethynyl-3-hydroxytetrahydropyran]dicobalt(Co-Co)

Si Cl

N O O

Rx-ID: 15552876 View in Reaxys 2541/3247

Si

Si

N

N O

O

O

Rx-ID: 15556610 View in Reaxys 2542/3247

Si

Si O

O

N

N

O

Rx-ID: 15559332 View in Reaxys 2543/3247

NH Br

N

Cl

Br

O

O

Rx-ID: 9385422 View in Reaxys 2544/3247

O O

O

N

NH

O

O

O

N O

OH

O

N O

O

O O

Rx-ID: 4729217 View in Reaxys 2545/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

322/428

2016-08-04 14:49:45


O N

NH O

N O

O

O

O O

Rx-ID: 17240152 View in Reaxys 2546/3247

O N

NH O

OH

N O

O

O

O O

Rx-ID: 17253558 View in Reaxys 2547/3247 O

NH

O

N

O

O

N

O

O

O

O

O

O O

N

O

O

Rx-ID: 29097441 View in Reaxys 2548/3247 O

O

O

N

O

N

O

O O

N

O

O

NH 2

O

Rx-ID: 3617472 View in Reaxys 2549/3247

O O

NH NH O O

Rx-ID: 5635329 View in Reaxys 2550/3247

N O O

N

O

O

Rx-ID: 6670765 View in Reaxys 2551/3247

N O O

N

O

O

Rx-ID: 6670766 View in Reaxys 2552/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

323/428

2016-08-04 14:49:45


N O O

N

O

O

Rx-ID: 6670767 View in Reaxys 2553/3247 O O

NH

O

O

O

N O NH 2

O

Rx-ID: 18831956 View in Reaxys 2554/3247 O

N

O

N

OH

O

O NH 2

O

Rx-ID: 18841041 View in Reaxys 2555/3247 O O

N

O

O

O

N O NH 2

O

Rx-ID: 18842663 View in Reaxys 2556/3247 O

N

O

N

O

O

O

O

NH 2

O

Rx-ID: 18844329 View in Reaxys 2557/3247 O

O

O

N

O

N O

O

NH 2

O

O

Rx-ID: 18845377 View in Reaxys 2558/3247 O

NH 2

O

O

O N

O

O

O N

H 2N

O

N

O O

O O

Rx-ID: 29147688 View in Reaxys 2559/3247 NH 2

O O

O

O N

O O

N

O O

Rx-ID: 29379146 View in Reaxys 2560/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

324/428

2016-08-04 14:49:45


S

HN

H N

N

O NH

N

S

Cl

N

O

O

Rx-ID: 5280262 View in Reaxys 2561/3247

N Cl

O

Rx-ID: 5613951 View in Reaxys 2562/3247 O

NH

Br

Br

Br

N

O

Rx-ID: 28628844 View in Reaxys 2563/3247 O

Br

NH N

Br

Br

O

Rx-ID: 28783482 View in Reaxys 2564/3247 O Br

NH

Br

N

Br

O

Rx-ID: 33576289 View in Reaxys 2565/3247

O

O

O

NH

O

NH

O

O

O

O

N

O

O

Rx-ID: 8942546 View in Reaxys 2566/3247

NH O

O

O

NH

O

O

O O

N

O

O

Rx-ID: 15043972 View in Reaxys 2567/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

325/428

2016-08-04 14:49:45


OH

N O O

N

O

O

Rx-ID: 6802174 View in Reaxys 2568/3247

NH

N N

NH

NH HN

O

NH

N H

NH

O NH

Rx-ID: 2584691 View in Reaxys 2569/3247 S

N O O

NH 2

Rx-ID: 5833599 View in Reaxys 2570/3247

N N Cl

O

Rx-ID: 5617688 View in Reaxys 2571/3247

N

N Cl

O

Rx-ID: 6610693 View in Reaxys 2572/3247 O N

Br

E HN

Rx-ID: 23353069 View in Reaxys 2573/3247 O O

O

N

O O

O

O

O

O

O

N

OH O

Rx-ID: 9915101 View in Reaxys 2574/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

326/428

2016-08-04 14:49:45


O

O

O

O

O

O

NH

N

O

O

O

O

NH

O

O O

O

NH

O O

O O

Rx-ID: 9973210 View in Reaxys 2575/3247 O

O

O

NH

O

O

O

O

O

O

N

OH O

Rx-ID: 12962835 View in Reaxys 2576/3247

O

O O

O O

N

N

N

O

N

O

OH

O

O

O

Rx-ID: 12962851 View in Reaxys 2577/3247

O

O O

O

O

N

O

OH

O

O

O

Rx-ID: 12963822 View in Reaxys 2578/3247 O

O

O

N

O

O

O

O

O

O

N

OH O

Rx-ID: 12971004 View in Reaxys 2579/3247

N O O

Z H

O

H

O

O

H

N O

O

OH

HO N

O

HO

O

OH

O

O

O

Rx-ID: 9366805 View in Reaxys 2580/3247

N

Z O

O OH

O

N

HO

H O

H

O

O O

H

O

HO

OH

N

O O

O O

Rx-ID: 9366806 View in Reaxys 2581/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

327/428

2016-08-04 14:49:45


O Cl

O

O

NH

O

N

O

O

Cl O

O

O

Rx-ID: 31845113 View in Reaxys 2582/3247 O

O

NH Br Cl

O

O

N

O

Cl

O

Rx-ID: 33590165 View in Reaxys 2583/3247 O

NH

Br

N

Br

Br

Rx-ID: 29108347 View in Reaxys 2584/3247 O Br

NH N

Rx-ID: 32945879 View in Reaxys 2585/3247 O Br

NH N

Br

Rx-ID: 32945916 View in Reaxys 2586/3247 O Br

NH N

isoamyl halide

Br O

Rx-ID: 32945952 View in Reaxys 2587/3247 O Br

O S NH

O

Na +

N

O–

Rx-ID: 32945956 View in Reaxys 2588/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

328/428

2016-08-04 14:49:45


O Br

O

O

S

N

+ O– Na

N O

Rx-ID: 32945966 View in Reaxys 2589/3247 O Br

NH N

3-methylbutyl halide

Br O

Rx-ID: 36255901 View in Reaxys 2590/3247 O

Br

Br

O

N

N

Rx-ID: 38895597 View in Reaxys 2591/3247 F

N O O

N

O

O

Rx-ID: 6802175 View in Reaxys 2592/3247

NH

O O

S O

N

O S

N O

N

O

S O

O

O

O

Rx-ID: 3545213 View in Reaxys 2593/3247

NH

N N S O

O

O

O

Rx-ID: 21936998 View in Reaxys 2594/3247

NH

N

Cl

N

S O

S

O

O

O

O

O

Rx-ID: 21950936 View in Reaxys 2595/3247 O

NH

N

O

N

N

Br

Cl

O

Br O

Rx-ID: 29134844 View in Reaxys 2596/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

329/428

2016-08-04 14:49:45


NH

N

O

NH

O O

O

O

O

S

O

S

O

O

O

Rx-ID: 8703429 View in Reaxys 2597/3247 O

O

F

F Cl

SH

N

N O

O

O

O

Rx-ID: 38882810 View in Reaxys 2598/3247

N

N Br O

O

Rx-ID: 8995654 View in Reaxys 2599/3247

N O O

Cl

O

Rx-ID: 6614056 View in Reaxys 2600/3247

NH

O

O

NH

N O

Br

O

Br

O

O

Rx-ID: 180772 View in Reaxys 2601/3247

Br

NH

Br

O

O

NH

N O

O

O

O

Rx-ID: 8674033 View in Reaxys 2602/3247

O

NH

O

NH

N O

O

O

Br

Br

O

Rx-ID: 8678098 View in Reaxys 2603/3247 Br

O O O

N

Rx-ID: 10581583 View in Reaxys 2604/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

330/428

2016-08-04 14:49:45


O

N

H N

O

NH

O

O

Br

Br

O

Rx-ID: 22204410 View in Reaxys 2605/3247

O

NH

HN

Br O

Br

H 2N

O

Rx-ID: 22205053 View in Reaxys 2606/3247

NH

O O

Br

O

NH

O

Br O

Rx-ID: 23921469 View in Reaxys 2607/3247 Br

O N

O

O

O

O

N

Br

Rx-ID: 24799779 View in Reaxys 2608/3247 O

O

O Br

O Br

OH NH

O

OH

NH

O

Rx-ID: 37929285 View in Reaxys 2609/3247 O

O

O Br

O Br

O

HO

NH

O

O

NH

O

Rx-ID: 37929294 View in Reaxys 2610/3247 O

O

O Br

O

OH

Br

I

O NH

NH

Rx-ID: 37929296 View in Reaxys 2611/3247 O

O

O Br

O

O NH

O

Br

O NH

O

Rx-ID: 37929305 View in Reaxys 2612/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

331/428

2016-08-04 14:49:45


O

Br

N

O

Rx-ID: 29338799 View in Reaxys 2613/3247

N

N

Br

Si

Si

O

O

Rx-ID: 9186829 View in Reaxys 2614/3247

Cl

Cl

O

NH

O

NH

HO O Cl

O

O

Cl

O

Rx-ID: 5213542 View in Reaxys 2615/3247 Cl

I

N

N

O

O

Rx-ID: 5292339 View in Reaxys 2616/3247

N

I

O

Rx-ID: 6592693 View in Reaxys 2617/3247 I NH

N

2,4-Cl2C6H3CH2X O

O

Rx-ID: 16167459 View in Reaxys 2618/3247 I

NH O

I

O

N

I

Rx-ID: 24197495 View in Reaxys 2619/3247 O O N

OH NH

N

O

O N

O

O

O N H

Rx-ID: 1795877 View in Reaxys 2620/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

332/428

2016-08-04 14:49:45


O O N

OH

F

N

O O

NH

N

N

O

O

O

O

O N O

O

N H

Rx-ID: 2435400 View in Reaxys 2621/3247 O O

O

O

N

O

O

O

NH

O

O

Rx-ID: 11113307 View in Reaxys 2622/3247 O

NH N O

O

Rx-ID: 11438669 View in Reaxys 2623/3247 O

NH N O

O

Rx-ID: 11470366 View in Reaxys 2624/3247 O

OH

E

O N

O

N

O

O

Rx-ID: 13426020 View in Reaxys 2625/3247 O

O Br

E

E O

O

N

O

Rx-ID: 13429649 View in Reaxys 2626/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

333/428

2016-08-04 14:49:45


O

E O

O

O

N

NH 2

O

Rx-ID: 13430359 View in Reaxys 2627/3247 O

E

O

O

N

O

N

O

O

O

Rx-ID: 13431223 View in Reaxys 2628/3247 O

NH 2

E

O N

O

O

N

O

Rx-ID: 13442255 View in Reaxys 2629/3247 O

HO

NH

E O

N

N

O

Rx-ID: 13450084 View in Reaxys 2630/3247 O

E O

I

O

O

N

NH 2

O

Rx-ID: 13450184 View in Reaxys 2631/3247 O O O

E

NH

O

N

N

O

Rx-ID: 13451209 View in Reaxys 2632/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

334/428

2016-08-04 14:49:45


O I

E

NH E

O

O

N

N O

O

Rx-ID: 13452502 View in Reaxys 2633/3247 O O O O

E

N

O

N

N

O

Rx-ID: 13453023 View in Reaxys 2634/3247 O

O HO

O

E

N O

N

N

O

Rx-ID: 13453526 View in Reaxys 2635/3247 O

O

O O

O

E

N O

N

N

O

Rx-ID: 13454896 View in Reaxys 2636/3247 OH

O

O E O

E O

N

N

O

O

Rx-ID: 13456102 View in Reaxys 2637/3247 O

O O

E O

N

E O

N

N

O

Rx-ID: 13456448 View in Reaxys 2638/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

335/428

2016-08-04 14:49:45


I

O

O

N Sn

O

O

N O

O

Rx-ID: 38205011 View in Reaxys 2639/3247

O

NH N

O

O

O

Rx-ID: 38205043 View in Reaxys 2640/3247

O

NH N

I

O

O

O

Rx-ID: 38205056 View in Reaxys 2641/3247

NH

Si

NH NH

O

F

HO

O

F

Tl

O

O

F

O

F

O

O

O

Si

F

F

Rx-ID: 1943303 View in Reaxys 2642/3247 Cl Cl

O HN

O

N

O O

Cl Cl

O

Rx-ID: 32657682 View in Reaxys 2643/3247 Cl

Cl Cl

N

Cl

O

N

N

O

O O

O O

Rx-ID: 32657691 View in Reaxys 2644/3247 N

N

O O

O O

Rx-ID: 5647250 View in Reaxys 2645/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

336/428

2016-08-04 14:49:45


O

N

O

N

N N

O

O

N

Rx-ID: 40119853 View in Reaxys 2646/3247 O

N

N

N

O O

N

N N N

O

O

O N

N

Rx-ID: 40120003 View in Reaxys 2647/3247 O

N

O

O

N

O O

N

O

O

N

N

Rx-ID: 40120009 View in Reaxys 2648/3247 O

N

N

N

O

N

O

O

N

O

N

O

O N

N

Rx-ID: 40120018 View in Reaxys 2649/3247 O

O

O

N N N

O O

O

O N N

Rx-ID: 40120040 View in Reaxys 2650/3247

S

HN

H N

N

N

Cl

N

NH S

N

S N

H N

N

O

Rx-ID: 5280261 View in Reaxys 2651/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

337/428

2016-08-04 14:49:45


Cl

NH

Br

N

Br O

O

Rx-ID: 24124438 View in Reaxys 2652/3247

NH

NH

O

O O

I

O

Rx-ID: 1751861 View in Reaxys 2653/3247 O

O N

N

O

I

O

Rx-ID: 1796375 View in Reaxys 2654/3247

NH

NH

O

O

I

O

Rx-ID: 18771709 View in Reaxys 2655/3247 O

OH

N

N

I

O

Rx-ID: 20166801 View in Reaxys 2656/3247 O

O

N

N

I

O

Rx-ID: 20167568 View in Reaxys 2657/3247 O N

O

anhydroformaldehyde o-toluidine

N O

I

O

Rx-ID: 20171136 View in Reaxys 2658/3247 O N

N

O

O N

E

I

O

Rx-ID: 20171479 View in Reaxys 2659/3247 O

O N I

N

I

O N O

Rx-ID: 28628847 View in Reaxys 2660/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

338/428

2016-08-04 14:49:45


O

O

NH NH

O

O

O

Br

Rx-ID: 24826884 View in Reaxys 2661/3247 -1 O

F

O

(v4)

F

B FF

O

O CH +

O

O

O

O

NH

E N

O

O

N H O

Rx-ID: 3417844 View in Reaxys 2662/3247

O

O HN

O

O NH O

Rx-ID: 25208106 View in Reaxys 2663/3247

Si

Si

N

O

N

N

Li

O

Rx-ID: 4784732 View in Reaxys 2664/3247

Si

Si

N

N

N

O

O

Rx-ID: 8957664 View in Reaxys 2665/3247

Si

NH N

polyindole/s(?)

O

Rx-ID: 17154348 View in Reaxys 2666/3247

Si

Cl Si

N

O

Rx-ID: 17157064 View in Reaxys 2667/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

339/428

2016-08-04 14:49:45


Si

Si

N

N

O

Rx-ID: 17166245 View in Reaxys 2668/3247

Si

Si N

N

Br

O

Rx-ID: 17169484 View in Reaxys 2669/3247

NH

Si

Cl N

Si O

O

Rx-ID: 33984760 View in Reaxys 2670/3247 O Br

NH

O S Cl

Br

N

O

S

O

O

O

Rx-ID: 41754836 View in Reaxys 2671/3247 O Br

NH

O S Cl

N

Br

O

O

O

S

O

Rx-ID: 41754840 View in Reaxys 2672/3247 O O

O

NH

N H

Br

NH

O

O

N

O

Rx-ID: 28970353 View in Reaxys 2673/3247

NH

NH

Br

Br O

Br

O

Rx-ID: 4245336 View in Reaxys 2674/3247

Br

Br

NH

O

NH

Br

O

Rx-ID: 4247135 View in Reaxys 2675/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

340/428

2016-08-04 14:49:45


Br

NH

Br O

Rx-ID: 6654926 View in Reaxys 2676/3247

Br

NH

NH

Br

NH

Br

NH

Br

O

O

O

O

Rx-ID: 8742270 View in Reaxys 2677/3247 O

O

Br

O

Br

N

Br

N

O

NH

Br

OH

Rx-ID: 28628829 View in Reaxys 2678/3247 O

O

Br

Br

N

NH

Br

O

Rx-ID: 28628830 View in Reaxys 2679/3247 Br

Br

O

NH

N

O NH Br

Br

Rx-ID: 29517199 View in Reaxys 2680/3247 O

Br

O

NH

Br

Br

NH

Br

O

Rx-ID: 30829084 View in Reaxys 2681/3247 OH Br

NH

Br

NH

Br

Br

O

Rx-ID: 30829087 View in Reaxys 2682/3247

NH

Br

O

O

NH

Br O

Rx-ID: 30829091 View in Reaxys 2683/3247

Br

Br

NH N

Br

NH

O

Br O

Rx-ID: 31274816 View in Reaxys 2684/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

341/428

2016-08-04 14:49:45


Br

NH

Br

Br

NH

Br OH

O

O

Rx-ID: 37755004 View in Reaxys 2685/3247

F O

O

O

F

F

F

O F

N

F NH

F

F

F

O N

O

F

O

F

F

O

Rx-ID: 2359584 View in Reaxys 2686/3247

O N

E

O

O

O

N O

E

O

O O OH

O

Rx-ID: 4282701 View in Reaxys 2687/3247 O O N

O

O

O

Rx-ID: 6805019 View in Reaxys 2688/3247

O

NH

O

O

O

O

O O

O N

O

O O

O O

Rx-ID: 10116150 View in Reaxys 2689/3247 O O NH

Br O

O

O

NH

N O

O O

O

O O

Rx-ID: 24962607 View in Reaxys 2690/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

342/428

2016-08-04 14:49:45


O O

O

O O

NH

O

O

O

O

N O

O

O

O

Rx-ID: 35518631 View in Reaxys 2691/3247 O O

O

O

O

O O

O

O

NH

NH

O

O

E

NH

O O

O

Z

O O

Rx-ID: 36422600 View in Reaxys 2692/3247

O

O

NH

O O

N

O

O

O O

Rx-ID: 37471374 View in Reaxys 2693/3247

O O

O N

O O

N

O O

O O

Rx-ID: 37471378 View in Reaxys 2694/3247

OH O

O

O

O

O

O

O

O N

N

O

O O

O O

Rx-ID: 37471384 View in Reaxys 2695/3247 O

O

O

O

O

O

O NH

Cl

O O

Rx-ID: 37929275 View in Reaxys 2696/3247 O O

NH

O O

O

S

O

S O

O

O

NH

O O

Rx-ID: 37929279 View in Reaxys 2697/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

343/428

2016-08-04 14:49:45


O

O

NH

Hal-(CH2)4CO2Et

O

N

O O O

Rx-ID: 9443479 View in Reaxys 2698/3247

N NH

HN O

O O

Rx-ID: 5628484 View in Reaxys 2699/3247 N

S

N O O

NH 2

Rx-ID: 5837815 View in Reaxys 2700/3247 O

NH

Si

N

Br

O O

O

Si

Rx-ID: 29854304 View in Reaxys 2701/3247 O

O

O

N

O

N

O

O O

N

O

O

NH 2

O

Rx-ID: 3617895 View in Reaxys 2702/3247 O O

N O NH 2

O

Rx-ID: 5839423 View in Reaxys 2703/3247 O O

N O NH 2

O

Rx-ID: 5839424 View in Reaxys 2704/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

344/428

2016-08-04 14:49:45


N O O

N

O

O

Rx-ID: 6671459 View in Reaxys 2705/3247 O O

NH

O

O

O

N O NH 2

O

Rx-ID: 18831957 View in Reaxys 2706/3247 O

N

O

N

OH

O

O NH 2

O

Rx-ID: 18841042 View in Reaxys 2707/3247 O O

N

O

O

O

N O NH 2

O

Rx-ID: 18842664 View in Reaxys 2708/3247 O

N

O

N

O

O

O

O

NH 2

O

Rx-ID: 18844330 View in Reaxys 2709/3247 O

O

O

N

O

N O

O

NH 2

O

O

Rx-ID: 18845378 View in Reaxys 2710/3247 O

O

O

N

O

N

O

O O

N

O

O

NH 2

O

Rx-ID: 18848832 View in Reaxys 2711/3247

O

OH

N

O

N

O O

N

O S

S

O NH 2

O

Rx-ID: 18849165 View in Reaxys 2712/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

345/428

2016-08-04 14:49:45


O

OH

N

O

N

O O

N

O

S

O S

NH 2

O

Rx-ID: 18849371 View in Reaxys 2713/3247

O

O

N

O

N O O

N

O

S

O S

NH 2

O

Rx-ID: 18849450 View in Reaxys 2714/3247 O O

O

N

O

N O O

N

O

S

O S

NH 2

O

Rx-ID: 18850266 View in Reaxys 2715/3247 O O

O

N

O

N O O

N

O

S

O S

NH 2

O

Rx-ID: 18850565 View in Reaxys 2716/3247 O

C

S

O

N

N

HN

Rx-ID: 41432300 View in Reaxys 2717/3247

O NH

Cl

S

Cl

O

N

O

S

HN

N

Rx-ID: 41432305 View in Reaxys 2718/3247

O

N

NH 2

O O

N

O

O

Rx-ID: 5841984 View in Reaxys 2719/3247

NH

NH

Cl

Cl O

I

O

Rx-ID: 4245210 View in Reaxys 2720/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

346/428

2016-08-04 14:49:45


Cl

Cl

NH

NH

O

I

O

Rx-ID: 4247133 View in Reaxys 2721/3247

NH

NH

I

I O

Cl

O

Rx-ID: 4263981 View in Reaxys 2722/3247

I

I

NH

NH

O

Cl

O

Rx-ID: 4291602 View in Reaxys 2723/3247

O H 2N

I

NH

N

Cl

O

Rx-ID: 17964420 View in Reaxys 2724/3247

I

I

NH

NH

Cl

O

Rx-ID: 17989292 View in Reaxys 2725/3247

I

I

NH

NH

Cl

O

Rx-ID: 17989316 View in Reaxys 2726/3247

O I

I

NH

N

Cl

O

Rx-ID: 17989481 View in Reaxys 2727/3247 Br O

O

NH Br

N

Cl

O

O

Rx-ID: 4666966 View in Reaxys 2728/3247 Br O O

Br

N

O

O

Rx-ID: 17330030 View in Reaxys 2729/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

347/428

2016-08-04 14:49:45


Br O

O Br

N

OH

O

Rx-ID: 17337779 View in Reaxys 2730/3247 O

Br

NH Br

N

Br

O

Rx-ID: 28783481 View in Reaxys 2731/3247

OH

N

O

O O

N

O

O

Rx-ID: 5841985 View in Reaxys 2732/3247

O

O

O

O

O

NH

O

NH

O

O

N

O

O

Rx-ID: 8972092 View in Reaxys 2733/3247 O

O O

O N

O

N

O

O

O

O

N

O

Rx-ID: 11083721 View in Reaxys 2734/3247 O O

N

N

O O

O

O

O

O

N

O

Rx-ID: 11564499 View in Reaxys 2735/3247

NH

O

O

O

O

O

NH

O

O

N

O

O

Rx-ID: 15052884 View in Reaxys 2736/3247

Cl

NH

HO

O

O

O O

O

O

O

O O

Z HN

NH

O

O

Cl

O

Cl

NH

N O

Rx-ID: 38746351 View in Reaxys 2737/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

348/428

2016-08-04 14:49:45


O N

Br

E N

Rx-ID: 23353068 View in Reaxys 2738/3247 O

O

O

N

N

O O

O

O

O

O

O

N

O O

Rx-ID: 9973232 View in Reaxys 2739/3247 O

O

O

NH

O

O

O

O

O

O

N

O O

Rx-ID: 12962836 View in Reaxys 2740/3247

O

O O O O

N

N

N

O

N

O

O

O

O

O

Rx-ID: 12962852 View in Reaxys 2741/3247

O

O O

O

O

N

O

O

O

O

O

Rx-ID: 12963823 View in Reaxys 2742/3247 O

O S

N

O K+

N

O

S–

S

O

Cl

S O

Rx-ID: 28761218 View in Reaxys 2743/3247 O Br

Br

N

Rx-ID: 42216101 View in Reaxys 2744/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

349/428

2016-08-04 14:49:45


O Br

NH N

Br

Rx-ID: 42216108 View in Reaxys 2745/3247 Br

O Br

N

N

O

N

Rx-ID: 42216115 View in Reaxys 2746/3247

NH

NH

H 2N OH

OH O

O

OH

O

O

O

OH

NH 2

O

HO

O NH

NH

NH 2 OH

O

N

OH

O

NH 2

O OH

O

O

O HO

NH

NH

OH

OH NH

Rx-ID: 33035256 View in Reaxys 2747/3247 O O

N O

N

Cl

Rx-ID: 28907177 View in Reaxys 2748/3247

N

O

O

N

N

O

O

O

O

Rx-ID: 2603558 View in Reaxys 2749/3247

O O

NH

O S

Si

Cl

O

Si

S N

O

O

Rx-ID: 5048448 View in Reaxys 2750/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

350/428

2016-08-04 14:49:45


NH

Cl Si

O

N

O

O

Si

NH

Cl

O

Rx-ID: 29475209 View in Reaxys 2751/3247 O Cl

NH

N Si

Cl

O

O

Cl

O Si

Rx-ID: 29653322 View in Reaxys 2752/3247 Br O

NH

O O

Rx-ID: 5615941 View in Reaxys 2753/3247 O Cl

O

SH

O N

N Cl

O

O

Cl O

Rx-ID: 38882813 View in Reaxys 2754/3247 O O

SH

O Cl

N

Cl

N Cl

O

O

O

Rx-ID: 38882815 View in Reaxys 2755/3247 Cl

I

N

N

O

O

Rx-ID: 3676769 View in Reaxys 2756/3247 I

NH N

O O

Rx-ID: 17196020 View in Reaxys 2757/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

351/428

2016-08-04 14:49:45


O

O

O

O

O

O

NH F F

O N

F

F

O F

F

O

Rx-ID: 36699863 View in Reaxys 2758/3247

O

NH

F

O N

F F

F F

F

O

Rx-ID: 36699935 View in Reaxys 2759/3247

Si

O

O

NH Sn

Br

NH

O

Si

O

Rx-ID: 28478216 View in Reaxys 2760/3247 O

N

Br

Rx-ID: 40759322 View in Reaxys 2761/3247 O

N

N

O

N

Rx-ID: 40759325 View in Reaxys 2762/3247 O

N NH

Rx-ID: 40759331 View in Reaxys 2763/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

352/428

2016-08-04 14:49:45


Cl

NH

O

O

O

Cl O

O

O Cl

O

N Cl

O O

Rx-ID: 9642263 View in Reaxys 2764/3247

O

O

O

Cl

O

O

O

O

NH

N

Cl

Cl

O

Cl O

Rx-ID: 9648953 View in Reaxys 2765/3247 O O

N

O

O Cl

N

E

Cl

N

Cl O

Rx-ID: 13630703 View in Reaxys 2766/3247 O Cl

O

N

O

O Cl

E

N Cl

N O

Rx-ID: 13630904 View in Reaxys 2767/3247 O NH 2

OH

E

O N

O

N

O

O

Rx-ID: 13426029 View in Reaxys 2768/3247 O NH 2

O Br

E

E O

O

N

O

Rx-ID: 13429652 View in Reaxys 2769/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

353/428

2016-08-04 14:49:45


O NH 2 E O

O

O

N

NH 2

O

Rx-ID: 13430365 View in Reaxys 2770/3247 O NH 2 E

O

O

N

O

N

O

O

O

Rx-ID: 13431229 View in Reaxys 2771/3247 O NH 2

NH 2

E

O N

O

O

N

O

Rx-ID: 13442264 View in Reaxys 2772/3247 O

HO

NH 2

NH

E O

N

N

O

Rx-ID: 13450090 View in Reaxys 2773/3247 O NH 2 E O

I

O

O

N

NH 2

O

Rx-ID: 13450190 View in Reaxys 2774/3247 O O

NH 2 O

E

NH

O

N

N

O

Rx-ID: 13451215 View in Reaxys 2775/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

354/428

2016-08-04 14:49:45


O I

NH 2 E

NH E

O

O

N

N O

O

Rx-ID: 13452508 View in Reaxys 2776/3247 O O O O

NH 2 E

N

O

N

N

O

Rx-ID: 13453028 View in Reaxys 2777/3247 O O HO

NH 2

O

E

N

O

N

N

O

Rx-ID: 13453530 View in Reaxys 2778/3247 O O

O O

NH 2

O

E

N

O

N

N

O

Rx-ID: 13454901 View in Reaxys 2779/3247 O

OH

NH 2

O

E

E O

O

N

N

O

O

Rx-ID: 13456103 View in Reaxys 2780/3247 O

O O

NH 2

E O

N

E O

N

N

O

Rx-ID: 13456450 View in Reaxys 2781/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

355/428

2016-08-04 14:49:45


O O

N

O

H N

N

N Cl

O

O

O

Rx-ID: 30234822 View in Reaxys 2782/3247 O

N

O

O

N

O

O

O

O

O

Rx-ID: 30234856 View in Reaxys 2783/3247 O

N

NH

N

Cl

O

O

O

Rx-ID: 30234884 View in Reaxys 2784/3247

H N

S

HN

O

N

O NH

N

S

Cl

N

O

N

N

S

H N

N

O

Rx-ID: 5280263 View in Reaxys 2785/3247

O

NH

N

I

O

I

Cl

O

O

Rx-ID: 10216137 View in Reaxys 2786/3247

O

O

N

N I

O

O

Rx-ID: 10420255 View in Reaxys 2787/3247

O NH I

N I

O

Rx-ID: 14425669 View in Reaxys 2788/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

356/428

2016-08-04 14:49:45


OH O

NH 2

O

E O

O

OH

O

N

O

O

N

O

N

E

E

E

O

N

O

N

O

Rx-ID: 9751790 View in Reaxys 2789/3247 OH

OH

O

O

E O

E

N

O

N

O

N

Rx-ID: 9751791 View in Reaxys 2790/3247 OH

OH

O

O E

E

O

NH

O

NH

O

N

Rx-ID: 9752747 View in Reaxys 2791/3247 OH O OH

E

O N

O

N

O

O

Rx-ID: 13426026 View in Reaxys 2792/3247 OH O

OH

E

O N O

O

NH

O

Rx-ID: 13426033 View in Reaxys 2793/3247 OH O O Br

E

E O

O

N

O

Rx-ID: 13429650 View in Reaxys 2794/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

357/428

2016-08-04 14:49:45


OH O E O

O

O

N

NH 2

O

Rx-ID: 13430362 View in Reaxys 2795/3247 OH O

E

O O

O

NH 2

NH

O

Rx-ID: 13430368 View in Reaxys 2796/3247 OH O E

O

N

O O

N

O

O

O

Rx-ID: 13431226 View in Reaxys 2797/3247 OH O

E

O

N

O O

O

O

NH

O

Rx-ID: 13431232 View in Reaxys 2798/3247 OH O NH 2

E

O N

O

N

O

O

Rx-ID: 13442261 View in Reaxys 2799/3247 OH O

NH 2

E

O N O

O

NH

O

Rx-ID: 13442268 View in Reaxys 2800/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

358/428

2016-08-04 14:49:45


OH O

O Cl

E

E

O O

NH

O

Rx-ID: 13449238 View in Reaxys 2801/3247 OH

HO

O

NH

E O

N

N

O

Rx-ID: 13450087 View in Reaxys 2802/3247 OH O

HO

NH

E

O

NH

N

O

Rx-ID: 13450093 View in Reaxys 2803/3247 OH O E O

I

O

O

N

NH 2

O

Rx-ID: 13450187 View in Reaxys 2804/3247 OH O

E

O

I

O

O

NH 2

NH

O

Rx-ID: 13450193 View in Reaxys 2805/3247 OH O

O O

E

NH

O

N

N

O

Rx-ID: 13451212 View in Reaxys 2806/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

359/428

2016-08-04 14:49:45


OH O

O O

NH

E

O

NH

N O

Rx-ID: 13451218 View in Reaxys 2807/3247 OH I

O E

NH E

O

O

N

N O

O

Rx-ID: 13452505 View in Reaxys 2808/3247 OH O

I NH

E

E O

O

N

NH

O O

Rx-ID: 13452511 View in Reaxys 2809/3247 OH O O O

O E

N

O

N

N

O

Rx-ID: 13453025 View in Reaxys 2810/3247 OH O

O O O

N

E

O

NH

N O

Rx-ID: 13453031 View in Reaxys 2811/3247 OH O HO

O

O

E

N

O

N

N

O

Rx-ID: 13453528 View in Reaxys 2812/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

360/428

2016-08-04 14:49:45


OH O

O HO

O

E

N O

NH

N O

Rx-ID: 13453533 View in Reaxys 2813/3247 OH

O

O O

O

O

E

N O

N

N

O

Rx-ID: 13454898 View in Reaxys 2814/3247 OH O

O

O O

O

E

N O

NH

N O

Rx-ID: 13454904 View in Reaxys 2815/3247 O

OH O

O

E O

E

N

O

N

O

N

Rx-ID: 13456449 View in Reaxys 2816/3247 O

OH

O

O

E

O

E

NH

O

NH

O

N

Rx-ID: 13457384 View in Reaxys 2817/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

361/428

2016-08-04 14:49:45


O

OH

O

O

E

E

HO

O

NH

NH

O

N

Rx-ID: 13457391 View in Reaxys 2818/3247 OH

N

O

E

HN O

Br

E

O

O

NH

O

O

Rx-ID: 13457465 View in Reaxys 2819/3247 O

OH

O

O

E

E

O O

O O

N

NH

O

N

Rx-ID: 13458643 View in Reaxys 2820/3247 O

O O

O N

N O E O OH

Rx-ID: 37062066 View in Reaxys 2821/3247 O

O O

O O

N

P

N O

O

E O

O

Rx-ID: 37062082 View in Reaxys 2822/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

362/428

2016-08-04 14:49:45


O

O

NH O

N O E O

Rx-ID: 37062122 View in Reaxys 2823/3247 O

NH

O

O

N O

O E

O

Rx-ID: 37062127 View in Reaxys 2824/3247 O

N

O

O

N

O

O

O

O

O

Rx-ID: 30234882 View in Reaxys 2825/3247 O O

N

O

N

N

N H

Cl

O

O

O

Rx-ID: 30234883 View in Reaxys 2826/3247 O

N

NH

N

Cl O

O

O

Rx-ID: 30234909 View in Reaxys 2827/3247

Br

Br

NH

O

NH

Br

O

Rx-ID: 4247151 View in Reaxys 2828/3247

Br

NH

Br O

Rx-ID: 6594086 View in Reaxys 2829/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

363/428

2016-08-04 14:49:45


Br

N

Br O

Rx-ID: 6656814 View in Reaxys 2830/3247

Br

N

N

Br

N

Br

N

N Br

Br

Br

O

O

O

O

O

Rx-ID: 8743589 View in Reaxys 2831/3247

Br

Br

NH

NH

Br

O

Rx-ID: 17989298 View in Reaxys 2832/3247 N

N

N

N O O

N

O

O

Rx-ID: 6807735 View in Reaxys 2833/3247

N O

O O

O

O

Rx-ID: 6804947 View in Reaxys 2834/3247

O

O O

O

O

O

NH

O

O N

O

O O

O O

Rx-ID: 9587573 View in Reaxys 2835/3247

O O

Br

O

O

N N

O O

O

Rx-ID: 13604005 View in Reaxys 2836/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

364/428

2016-08-04 14:49:45


O

O O

N

O

O O

Rx-ID: 13612353 View in Reaxys 2837/3247

O

O

N

O

O

E

O

O O

N

O O

Rx-ID: 13615704 View in Reaxys 2838/3247

O

O

NH

O O

N

O

O O

Rx-ID: 13620945 View in Reaxys 2839/3247

O

O

O

Z

O

O

N

N

N

O

N O

Rx-ID: 13621130 View in Reaxys 2840/3247 O O

NH

O NH

O O

Rx-ID: 37929261 View in Reaxys 2841/3247 O O

O

O

O O

O

NH

Cl

O O

Rx-ID: 37929273 View in Reaxys 2842/3247 O O

NH

O O

O

S

O S

O

O

NH

O

O O

Rx-ID: 37929284 View in Reaxys 2843/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

365/428

2016-08-04 14:49:45


O O

O

NH

O

O

O

O

NH O

O

O

Rx-ID: 42642335 View in Reaxys 2844/3247

O O

NH

Hal-(CH2)5CO2Et

O

N

O O

O

Rx-ID: 9443482 View in Reaxys 2845/3247 O

O

O

O

Cl

N

O

NH

HO

O

Rx-ID: 28463794 View in Reaxys 2846/3247 O

O

O

O

O

O O

O

NH

N H

O

NH

N H

Rx-ID: 10592107 View in Reaxys 2847/3247 O

O

O

N

O O

O

O

O

NH

N H

O

O

N H

NH

Rx-ID: 23047557 View in Reaxys 2848/3247 O

C

S

O

N

N

HN

Rx-ID: 41432301 View in Reaxys 2849/3247

O NH Cl

S N

Cl O

S

O

N HN

Rx-ID: 41432306 View in Reaxys 2850/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

366/428

2016-08-04 14:49:45


F

F F

F

Cl N

N

F N

N

O

N

F

N

O

Rx-ID: 24729671 View in Reaxys 2851/3247

O

OH

O N

O N

E

E

O

O

O

O O

O

OH

O

Rx-ID: 4281347 View in Reaxys 2852/3247

N P

N

N

O

Rx-ID: 6615627 View in Reaxys 2853/3247

N Cl

O

Rx-ID: 5620402 View in Reaxys 2854/3247 O O

O O

O

O

O

N

N

O

N

O O

NH

O

O

O

O

O

Rx-ID: 9269903 View in Reaxys 2855/3247 O

NH

O

O

N

O

NH

O O O

Rx-ID: 14425222 View in Reaxys 2856/3247 O

O O

N

NH

O

N

O O

NH

O O O

Rx-ID: 14427093 View in Reaxys 2857/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

367/428

2016-08-04 14:49:45


O

O O

O

N

O

N

O

N

O

NH

O O O

Rx-ID: 14446042 View in Reaxys 2858/3247 O

O O

OH

N

O

N

O

N

O

NH

O O O

Rx-ID: 14446055 View in Reaxys 2859/3247 O

O

O

N

O

N

O

O O

O

N

O

O

Rx-ID: 3613927 View in Reaxys 2860/3247

O

N

O

O O

N

O

O

Rx-ID: 5843151 View in Reaxys 2861/3247

O

NH

O

O O

N

O

O

O

O

O

N

I N

O

O

O

Rx-ID: 8987522 View in Reaxys 2862/3247

O

O

O

O

O

N

O

NH

O

N

O

O

Rx-ID: 15052885 View in Reaxys 2863/3247

O

O

O

O

O

N

O

NH

O

O

N

O

O

Rx-ID: 15069722 View in Reaxys 2864/3247 O NH O

O

O

N

O

O O

N

O

O

Rx-ID: 18831959 View in Reaxys 2865/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

368/428

2016-08-04 14:49:45


O O

N

N O

OH

O

N

O

O

O

Rx-ID: 18841044 View in Reaxys 2866/3247 O

O

O

O

O

N

O

N

O

N

O

O

Rx-ID: 18842666 View in Reaxys 2867/3247 O O

N

N O

O

O

O

N

O

O

O

Rx-ID: 18844332 View in Reaxys 2868/3247 O

O

O O

O

N

O

O

N

O

O

O N

N

N

O

O

O

O

O

O

Rx-ID: 29147687 View in Reaxys 2869/3247 O O

NH

O O

O

F

S S

F

NH

O

O

O

O

O O

Rx-ID: 37929250 View in Reaxys 2870/3247 O O

NH

F

O

F

NH

O O

Rx-ID: 37929254 View in Reaxys 2871/3247 O O

O

O

O

F

O

O

NH

Cl

O O

Rx-ID: 37929276 View in Reaxys 2872/3247 O

N O N Cl

O

Rx-ID: 28907233 View in Reaxys 2873/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

369/428

2016-08-04 14:49:45


Br

NH

O

O

O

O

O

O

Br

O

N

O O

Rx-ID: 1806969 View in Reaxys 2874/3247

NH

O N

O

O

O

Br

O

O

O

O

Br O

Rx-ID: 8933865 View in Reaxys 2875/3247

Br

O

O

O O N

O

O

O

Br

NH

O O

Rx-ID: 9519941 View in Reaxys 2876/3247

O

O O

O

O

NH

O N

O Br

O Br

O

Rx-ID: 10035013 View in Reaxys 2877/3247

Br Br

NH

O O N

O

Rx-ID: 13814461 View in Reaxys 2878/3247

Br

Br

O O

O N

N O

O

Rx-ID: 13819467 View in Reaxys 2879/3247

Br

O O

NH Br

N

O

Rx-ID: 19918863 View in Reaxys 2880/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

370/428

2016-08-04 14:49:45


Br

O

NH

O

O Br

N

O

Cl

O O

Rx-ID: 27781836 View in Reaxys 2881/3247

O

NH

O N

Br Br

O

Rx-ID: 36679868 View in Reaxys 2882/3247

O

Br

NH

Br

O O

O

N

O

Rx-ID: 38442863 View in Reaxys 2883/3247

O

Br OH

Br

O O

O O

N

N

O

Rx-ID: 38443045 View in Reaxys 2884/3247

O Br

N

N

Br

O O

O

N O

O

Rx-ID: 38624701 View in Reaxys 2885/3247

O Br

O O

O

OH

N O

N

O

Rx-ID: 38624793 View in Reaxys 2886/3247

O O

NH N

Br Br O

Rx-ID: 42197238 View in Reaxys 2887/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

371/428

2016-08-04 14:49:45


O

N

NH

E

N

Br

E

O

E

N

O O

E

Rx-ID: 1647440 View in Reaxys 2888/3247 O 2

O O–

N

–N

Cl – (v2)

Zn Mg2+

N

Zn 2+

O

O

O ClLi

Rx-ID: 35257837 View in Reaxys 2889/3247

O

O

O

O

N

N

O S

SH

O

OH O

O

Rx-ID: 10163908 View in Reaxys 2890/3247

O

O

O

O

N

N

O S

Cl

O

OH O

O

Rx-ID: 12428219 View in Reaxys 2891/3247 O O

S

O

N O O

Rx-ID: 6629008 View in Reaxys 2892/3247 O O

S O

N O O

Rx-ID: 6803542 View in Reaxys 2893/3247

N N HO

Br

O O

OH

Rx-ID: 8999346 View in Reaxys 2894/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

372/428

2016-08-04 14:49:45


O NH

O

N

Cl O

O

Rx-ID: 34071715 View in Reaxys 2895/3247 O

O

O

O Br

Br

O NH

OH

O

NH

OH

O

O

Rx-ID: 37929307 View in Reaxys 2896/3247

O

N

N

H

N

O O

N

O

Se

O

O O

O

O

N

O

racemate

Rx-ID: 9237613 View in Reaxys 2897/3247 Br

O O

N

OH O

N O

O

N

N

O

Rx-ID: 13617466 View in Reaxys 2898/3247 Br

O N O

O N

N

O

O

N O

O

Rx-ID: 13629303 View in Reaxys 2899/3247 Br

O N O

O N

N O

O

O

N O

O

Rx-ID: 13629918 View in Reaxys 2900/3247 Br

O O

N

O

O N

O

N

O N

O

Rx-ID: 13630681 View in Reaxys 2901/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

373/428

2016-08-04 14:49:45


Br

O O

O

O

N

O

N

O

N

N

O

O

Rx-ID: 13632119 View in Reaxys 2902/3247 Cl

I

N

N

O

O

Rx-ID: 3676944 View in Reaxys 2903/3247 I

NH N

O O

Rx-ID: 17196022 View in Reaxys 2904/3247

Cl

I

N

N

O

O

Rx-ID: 24141538 View in Reaxys 2905/3247 O

F F

F HO

N

O

F F

F

N

O O

O

Rx-ID: 3755240 View in Reaxys 2906/3247 O

F

F F

NH

N

F F

O

F

O

Rx-ID: 36699858 View in Reaxys 2907/3247

O

O

O

O

F

F

O

O

O

F

F F

N

F NH

O

O

Rx-ID: 36699861 View in Reaxys 2908/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

374/428

2016-08-04 14:49:45


N O F

N

F F

O O

Rx-ID: 28940284 View in Reaxys 2909/3247 O

O O

I

O I

O NH

OH

O

NH

O

Rx-ID: 37929230 View in Reaxys 2910/3247 O O

NH

I

OH

I

NH

Rx-ID: 37929260 View in Reaxys 2911/3247 O O

NH

I

OH

I

NH

O

Rx-ID: 37929267 View in Reaxys 2912/3247 O

O O

I

O I

OH NH

OH

OH

NH

O

Rx-ID: 37929290 View in Reaxys 2913/3247 O O

N NH

Br

Br

N

N

O Br

O

Rx-ID: 40569702 View in Reaxys 2914/3247

N

N

O

O

O

H 2N

O

OH

O

NH

Rx-ID: 3301219 View in Reaxys 2915/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

375/428

2016-08-04 14:49:45


N

NH O

I

O

O

OH NH

Rx-ID: 19838568 View in Reaxys 2916/3247

N

NH O

OH

O

O

OH NH

Rx-ID: 19856573 View in Reaxys 2917/3247

N

N

O

OH

O

OH

O

NH

Rx-ID: 19857724 View in Reaxys 2918/3247

O

O

O

Cl

NH

O

O

O

O

O N

O

O

O

O

Rx-ID: 10276712 View in Reaxys 2919/3247

O O

O

O

O HO

O

O

O N

O

O

O

Rx-ID: 12334983 View in Reaxys 2920/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

376/428

2016-08-04 14:49:45


O O

N O

N O N

Rx-ID: 28907173 View in Reaxys 2921/3247 O

O

N N

N O

Rx-ID: 28907237 View in Reaxys 2922/3247

Si

N

Si

N

O

O

Si

N

Br

N

O

O

O

Rx-ID: 8699473 View in Reaxys 2923/3247

NH

Si N

O O

O

Rx-ID: 15541184 View in Reaxys 2924/3247

Si

Cl

N

benzoyl haloide

Si

O

O

Rx-ID: 15543560 View in Reaxys 2925/3247

Si

Si

N

N

O

O

O

Rx-ID: 15566354 View in Reaxys 2926/3247

N

N

N

N

N

O

OH

O

N

O

O

N

OH

O OH

Rx-ID: 1812155 View in Reaxys 2927/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

377/428

2016-08-04 14:49:45


O O NH

O

OH

O

O O

O O

NH O

O

O

O O

Rx-ID: 42642311 View in Reaxys 2928/3247 O O

NH

O

O

O

NH

O O

Rx-ID: 37929269 View in Reaxys 2929/3247 O O

O

O

O

O

O

O

NH

Cl

O O

Rx-ID: 37929274 View in Reaxys 2930/3247 O

O

O

NH

O

O O

S S

O

NH

O

O

O

O O O

Rx-ID: 37929301 View in Reaxys 2931/3247 N

S

N O O

N

O

O

Rx-ID: 6805841 View in Reaxys 2932/3247 O

O

O

N O O

N

O

N O

S

O S

O

N

O

O

Rx-ID: 3620192 View in Reaxys 2933/3247 O O

N O O

N

O

O

Rx-ID: 6806868 View in Reaxys 2934/3247 O O

N O O

N

O

O

Rx-ID: 6806869 View in Reaxys 2935/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

378/428

2016-08-04 14:49:45


O

O

O

O

O

N

O

NH

N

O

O

O

Rx-ID: 18831961 View in Reaxys 2936/3247 O O

N

N O

OH

O

O

N

O

O

Rx-ID: 18841046 View in Reaxys 2937/3247 O

O

O

O

O

N

O

N

N

O

O

O

Rx-ID: 18842668 View in Reaxys 2938/3247 O O

N

N O

O

O

O

O

N

O

O

Rx-ID: 18844334 View in Reaxys 2939/3247 O

O

O

N

O

N

O

O O

O

N

O

O

Rx-ID: 18845381 View in Reaxys 2940/3247 O

O

O

N

O

N

O

O O

N

O

O

O

N

O

O

Rx-ID: 18848834 View in Reaxys 2941/3247

O O

N

O

OH

N

O

N O

O S

S O

N

O

O

Rx-ID: 18849166 View in Reaxys 2942/3247

O O

N

O

OH

N

O

N O

O S

S O

N

O

O

Rx-ID: 18849372 View in Reaxys 2943/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

379/428

2016-08-04 14:49:45


O

O

N O O

N

O

N O

O S

S

O

N

O

O

Rx-ID: 18849451 View in Reaxys 2944/3247 O

O

O

N O O

N

O

N O

O S

S O

N

O

O

Rx-ID: 18850267 View in Reaxys 2945/3247

O O

OH O

O

O

O NH

NH

NH

NH

OH

O O

O

O

Rx-ID: 3469797 View in Reaxys 2946/3247

O O

OH O

O

O

O NH

NH

NH

NH

OH

O O

O

O

Rx-ID: 3469798 View in Reaxys 2947/3247

O O

OH O

S

O

N

NH

NH OH O

Rx-ID: 19353559 View in Reaxys 2948/3247

O O

OH O

S

O

N

NH

NH OH O

Rx-ID: 19353560 View in Reaxys 2949/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

380/428

2016-08-04 14:49:45


OH O O

O

O

NH

NH

N

OH

O O

O

Rx-ID: 19363530 View in Reaxys 2950/3247

OH O O

O

O

NH

NH

N

OH

O O

O

Rx-ID: 19363531 View in Reaxys 2951/3247

NH

OH O

OH

O NH

NH

NH O

OH

OH O O

Rx-ID: 19391996 View in Reaxys 2952/3247

NH

OH O

OH

O NH

NH

NH O

OH

OH O O

Rx-ID: 19392001 View in Reaxys 2953/3247

OH O NH

OH

O

O

NH

NH

O N

OH O

O

Rx-ID: 19392059 View in Reaxys 2954/3247

OH O NH

OH

O

O

NH

NH

O N

OH O

O

Rx-ID: 19392065 View in Reaxys 2955/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

381/428

2016-08-04 14:49:45


O O

NH

OH O O NH

NH

NH O

O

O

OH

O

O

Rx-ID: 19392325 View in Reaxys 2956/3247

O O

NH

OH O O NH

NH

NH O

O

O

OH

O

O

Rx-ID: 19392329 View in Reaxys 2957/3247

O S

OH O O

N

O OH

NH

NH NH

OH O O

OH O

Rx-ID: 19392390 View in Reaxys 2958/3247

O S

OH O O

N

O OH

NH

NH NH

OH O O

OH O

Rx-ID: 19392405 View in Reaxys 2959/3247

OH O

O S

O

N

O

OH

N

NH

NH

O O

OH O

O

Rx-ID: 19392420 View in Reaxys 2960/3247

OH O

O S N

O

O

OH

N O

NH

NH

O O

OH O

Rx-ID: 19392436 View in Reaxys 2961/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

382/428

2016-08-04 14:49:45


Si O

F

N

O

Rx-ID: 27730081 View in Reaxys 2962/3247 O Br

NH

N Br

Br O

Rx-ID: 29837239 View in Reaxys 2963/3247 O Br N

Rx-ID: 30295665 View in Reaxys 2964/3247 O O

O

O

O

Cl

O

O

NH

Cl

O O

Rx-ID: 37929277 View in Reaxys 2965/3247 O

O

O

NH

O

O Cl

S S

Cl

NH

O

O

O

O O O

Rx-ID: 37929280 View in Reaxys 2966/3247

Br OH

Br

N

O O

N

O

O

O

O

Rx-ID: 38090771 View in Reaxys 2967/3247

Br

N

O

OH

N O

O

O

O

O

Rx-ID: 38090778 View in Reaxys 2968/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

383/428

2016-08-04 14:49:45


O O

N

Br

Br

N

O

O

O

O

O

Rx-ID: 38090785 View in Reaxys 2969/3247

Br

NH

Br

N

O

O

O

O

O

Rx-ID: 38090792 View in Reaxys 2970/3247

Br

N

O

Br

N

N

O O

O

O

O

Rx-ID: 38090804 View in Reaxys 2971/3247

Si

Si

N

Br

O

Br

N

N

Br

O

Rx-ID: 4631979 View in Reaxys 2972/3247

Si

Br

NH

Br

N

O

Rx-ID: 17370045 View in Reaxys 2973/3247

Si Br

Si

N

Cl

O

Rx-ID: 17382688 View in Reaxys 2974/3247

Si Br

N

Si Br

N

O

Rx-ID: 17391896 View in Reaxys 2975/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

384/428

2016-08-04 14:49:45


O

O

O

O

N

N

Br OH

O

OH

O

Rx-ID: 9099092 View in Reaxys 2976/3247

NH O

O

O

O

N Br OH

O

Rx-ID: 14730124 View in Reaxys 2977/3247

O

NH

O

N

OH

O

Br OH

O

Rx-ID: 14741573 View in Reaxys 2978/3247 O O

S

O

N O NH 2

O

Rx-ID: 5843142 View in Reaxys 2979/3247 O O

S O

N O NH 2

O

Rx-ID: 5843788 View in Reaxys 2980/3247 Cl

I

N

N

O

O

Rx-ID: 4364899 View in Reaxys 2981/3247 I

NH N

O O

Rx-ID: 17196024 View in Reaxys 2982/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

385/428

2016-08-04 14:49:45


I

Cl

Br

N

O

Rx-ID: 17198822 View in Reaxys 2983/3247

Si O

O

Si

O N

N I

O

O

O

Rx-ID: 38205030 View in Reaxys 2984/3247

Si O NH

N

O

O O

Rx-ID: 38205037 View in Reaxys 2985/3247

Si O NH

I

N

O

O O

Rx-ID: 38205050 View in Reaxys 2986/3247

O

O

O N

OH

I

O N

O

I

Rx-ID: 4001883 View in Reaxys 2987/3247 O

O

N

O O

I

O

O

NH

O O I

O

Rx-ID: 4896783 View in Reaxys 2988/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

386/428

2016-08-04 14:49:45


O

O O

NH

N

I

I

O

O

Rx-ID: 16880532 View in Reaxys 2989/3247

O

N

O N

I

I

O

I

Rx-ID: 18202056 View in Reaxys 2990/3247

O

O

O N

O N

I

O

I

Rx-ID: 18202675 View in Reaxys 2991/3247

O

O

O N

O N

Br

I

O

I

Rx-ID: 18203599 View in Reaxys 2992/3247

O

O

O N

O N

I

I

O

I

Rx-ID: 18204150 View in Reaxys 2993/3247 O

O O

I

O I

O NH

O

O

NH

O

Rx-ID: 37929227 View in Reaxys 2994/3247 O O

NH

I

O

I

NH

Rx-ID: 37929257 View in Reaxys 2995/3247 O O

NH

I

I O

O NH

Rx-ID: 37929264 View in Reaxys 2996/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

387/428

2016-08-04 14:49:45


O

O O

I

O I

OH NH

O

OH

NH

O

Rx-ID: 37929288 View in Reaxys 2997/3247 O

O

O

O I

OH

I

I

O

NH

NH

Rx-ID: 37929298 View in Reaxys 2998/3247 Cl

I

N

N O

O

O

O

Rx-ID: 9690018 View in Reaxys 2999/3247 I

NH

N

O O O

Rx-ID: 13512349 View in Reaxys 3000/3247 I

NH N

O O

O

O

Rx-ID: 13513216 View in Reaxys 3001/3247 O

O NH

O O

O

S N

O

N

O

E O

NH O

O

O O

Rx-ID: 8669122 View in Reaxys 3002/3247 O

N

NH

N

N

O

O

I N

O O

O

O

N

N

N

O

Rx-ID: 29854305 View in Reaxys 3003/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

388/428

2016-08-04 14:49:45


O O

N NH

N

Br

Br

N

O Br

O

Rx-ID: 40569703 View in Reaxys 3004/3247

O

NH O

O

F

S

F

F

O

O

NH

O

Si

O

O

O

HO

O

Si

Rx-ID: 9590261 View in Reaxys 3005/3247

O

NH O

NH

O O

O

O

Cl

O

Si

Rx-ID: 13622448 View in Reaxys 3006/3247

Cl

I

Cl

N

Cl

N

O

O

Rx-ID: 24141525 View in Reaxys 3007/3247

Cl

N Cl

Cl

N I

O

O

Rx-ID: 24141533 View in Reaxys 3008/3247

N Cl

O

Rx-ID: 5626289 View in Reaxys 3009/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

389/428

2016-08-04 14:49:45


O

O

N

N

F

Cl

F

I F

F

Rx-ID: 24141529 View in Reaxys 3010/3247 O

I NH

O S Cl

I

O

N

O

O

S

O

Rx-ID: 42782060 View in Reaxys 3011/3247 O

I NH

N O

O

S

O

Rx-ID: 42782074 View in Reaxys 3012/3247 Cl

NH Cl

Cl O

O

NH

Cl

N H

S

Cl

N S

O

O

O

O

Rx-ID: 3332960 View in Reaxys 3013/3247 Cl

NH

NH Cl

N S

O

O

O

O

Rx-ID: 21937003 View in Reaxys 3014/3247

O

N

N

O

O

Si

Si O

O

O

N

Si

O

O

O

O

O

Rx-ID: 8867343 View in Reaxys 3015/3247 O

NH

Rx-ID: 6621042 View in Reaxys 3016/3247

NH

NH

Br

Br O

I

O

Rx-ID: 4245337 View in Reaxys 3017/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

390/428

2016-08-04 14:49:45


Br

Br

NH

NH

O

I

O

Rx-ID: 4247136 View in Reaxys 3018/3247

NH

NH

I

I O

Br

O

Rx-ID: 4263982 View in Reaxys 3019/3247 I

I Br N

Br

NH

O

NH

O

Rx-ID: 4269194 View in Reaxys 3020/3247

I

I

NH

NH

O

Br

O

Rx-ID: 4291603 View in Reaxys 3021/3247 Br

Br NH

NH

O

O

I

Rx-ID: 4291612 View in Reaxys 3022/3247 Br

Br

NH

NH

O

I

Rx-ID: 17963086 View in Reaxys 3023/3247

O H 2N

I

NH

N

Br

O

Rx-ID: 17964421 View in Reaxys 3024/3247 I

O H 2N

Br

NH

N

O

Rx-ID: 17964423 View in Reaxys 3025/3247

I

NH

I

NH

Br

O

Rx-ID: 17989293 View in Reaxys 3026/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

391/428

2016-08-04 14:49:45


I

I

NH

NH

Br

O

Rx-ID: 17989317 View in Reaxys 3027/3247 I

I Br

Br

NH

NH

O

Rx-ID: 17989366 View in Reaxys 3028/3247 I

O Br

Br

NH

N

O

Rx-ID: 17989479 View in Reaxys 3029/3247

O I

I

NH

N

Br

O

Rx-ID: 17989482 View in Reaxys 3030/3247 I Br

I

O

Br

NH

N

O

Rx-ID: 17989623 View in Reaxys 3031/3247

F

NH

O

NH F

F

N

S F

F

O

F

S F

F

Br

F O F

Rx-ID: 35315789 View in Reaxys 3032/3247

O H HO

SH

O

O

O

N

O

N

NH

O

O O

O

S

NH

NH

N

OH

O

O

Rx-ID: 29721217 View in Reaxys 3033/3247

O

NH NH

O E O

O

O

Rx-ID: 24238288 View in Reaxys 3034/3247

O

O NH

E O O

O

NH

Rx-ID: 24239775 View in Reaxys 3035/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

392/428

2016-08-04 14:49:45


O

O

NH

E O NH

O

O

Rx-ID: 24268178 View in Reaxys 3036/3247 O N

O

O

O N

N

O

O

O

NH

O S

S O

O

O

O

O

Rx-ID: 35518868 View in Reaxys 3037/3247

N

N

O

Br O

O

O

O

O

Rx-ID: 9001711 View in Reaxys 3038/3247 O Br N

Si Cl

O

O

Si

Rx-ID: 23571884 View in Reaxys 3039/3247 O Br

NH

N

Si

Br

O

Cl

O

O Si

Rx-ID: 29002081 View in Reaxys 3040/3247

NH

NH

N

O Si

O

O

Br

Si

Br

O

Rx-ID: 29475183 View in Reaxys 3041/3247 Cl Cl Cl

NH Cl

O

O

Cl

Cl Cl

O O

Cl

N Cl

O

O

Rx-ID: 8773408 View in Reaxys 3042/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

393/428

2016-08-04 14:49:45


NH

O

Rx-ID: 6668278 View in Reaxys 3043/3247 O

O

Br

Br Cl

SH

N

N O

O

O

O

Rx-ID: 38882816 View in Reaxys 3044/3247 Cl

I

O

N

O

N

O

O

Rx-ID: 24141546 View in Reaxys 3045/3247

O

O

O

O HN NH

O

HO

NH O

Rx-ID: 25204073 View in Reaxys 3046/3247 O O

O HN

O NH

O

Rx-ID: 25208102 View in Reaxys 3047/3247

Cl

Cl

O

NH

O Si O

O Cl

NH

Cl

O

O

Rx-ID: 42063750 View in Reaxys 3048/3247

Cl

O

Cl

O Si

OH

Si

O

HO Cl

NH

O

Cl

NH

O

Rx-ID: 42063948 View in Reaxys 3049/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

394/428

2016-08-04 14:49:45


Cl

O

Cl

Si O

Cl

NH 2

NH

Cl

O

Rx-ID: 42064040 View in Reaxys 3050/3247

O

E

H N

N

O

Cl

Cl

Si O

O NH

Cl

Cl

O

Rx-ID: 42064124 View in Reaxys 3051/3247

Cl

NH

Cl

O

O Si O

O

NH

Cl

Cl

O

Rx-ID: 42064157 View in Reaxys 3052/3247

O

O

O NH

O O

O

S N

O

O

O

N

Z

O

O

E

HN

N

O

HN

O

Z

O

O

O

O

Rx-ID: 8932330 View in Reaxys 3053/3247 O

O N NH

Br

N

Br N

O

Br O

Rx-ID: 40569704 View in Reaxys 3054/3247 O

O

N

S

Cl

N I

S

Rx-ID: 24141543 View in Reaxys 3055/3247 O

O NH

O O

O

NH

N

O

O

O

F

F O

F

O

O

F

F

O

F

Rx-ID: 9973154 View in Reaxys 3056/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

395/428

2016-08-04 14:49:45


O

O O N

NH

O

Z

O O

O

N

N

F

O

O

O

F F

Rx-ID: 12938858 View in Reaxys 3057/3247 O O

O

NH

O O

O F O

O

O

F F

Rx-ID: 12958627 View in Reaxys 3058/3247 O O

NH

O

O

NH

O

O F

O

O

O

F

O

F

Rx-ID: 12963942 View in Reaxys 3059/3247

NH Br

HO

O

N Br

O

Rx-ID: 9385423 View in Reaxys 3060/3247 O O N O

O O

O

O

Rx-ID: 6643849 View in Reaxys 3061/3247

O

HO

O

O

O

O

NH

O

N

O

N

O

O O

O O

Rx-ID: 42319520 View in Reaxys 3062/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

396/428

2016-08-04 14:49:45


O

O

O

F

F

O

F

F

F

F

NH

N

N

F

F

F

O

F

F

O

F

O O

Rx-ID: 2359888 View in Reaxys 3063/3247

O O–

F

S

F F

O

O N

O

F

O

O

O N

F F

O

F

O

S

O

O

N+

F

S O

F

O

Rx-ID: 4198896 View in Reaxys 3064/3247

O

O

O NH

O

N

O

O

O NH

O

O S

O

S

O

O

O

O

Rx-ID: 8957729 View in Reaxys 3065/3247 O N

O

O

O

O

O

O

Rx-ID: 25540045 View in Reaxys 3066/3247

O

O

N

O E

N

O

O

Rx-ID: 24238289 View in Reaxys 3067/3247

O

O

O

NH

E O NH

O

O

O

Rx-ID: 24241566 View in Reaxys 3068/3247 O O NH Cl O

O O

O

O

Rx-ID: 6642945 View in Reaxys 3069/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

397/428

2016-08-04 14:49:45


O

O

O

NH

H N

O

O O

I

O

O

O

NH

I

O

HN

O

I

Rx-ID: 4904744 View in Reaxys 3070/3247

Si

Si

Br

NH

O O

O

O

Br

N

N

O

N

O

Rx-ID: 9642505 View in Reaxys 3071/3247 O O O

O

O

N Br

N

O

O

O

O

O

O

N Br NH

O

O

Rx-ID: 29792424 View in Reaxys 3072/3247

O

NH O

O O

O

O

N

O

O

N F

F F

O O

N

O

F

F F

Rx-ID: 2023156 View in Reaxys 3073/3247

O

O

NH 2

O

N

NH

N

O

F

F F

Rx-ID: 19588024 View in Reaxys 3074/3247

O

NH

O

N

O

NH F

F F

O

N

O

F

F F

Rx-ID: 19608483 View in Reaxys 3075/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

398/428

2016-08-04 14:49:45


O

NH

O

N

O

N O

F

F F

N

O

F

F F

Rx-ID: 19609499 View in Reaxys 3076/3247 O O

S

O

N O N

O

O

O

Rx-ID: 5659917 View in Reaxys 3077/3247 O S

O

O N O N

O

O

O

Rx-ID: 6809439 View in Reaxys 3078/3247

NH

O N

O

O

O I

O

O

O

O I

O

Rx-ID: 10192507 View in Reaxys 3079/3247

O

NH

O N

O I

O

Rx-ID: 38205034 View in Reaxys 3080/3247

I

Cl O

N

N

O

O

O

Rx-ID: 24141548 View in Reaxys 3081/3247 O

O

O

O I

O NH

O O

I

OH NH

OH O

Rx-ID: 37929229 View in Reaxys 3082/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

399/428

2016-08-04 14:49:45


O O

NH

I

OH

I

NH

OH O

Rx-ID: 37929259 View in Reaxys 3083/3247 O O

NH

I

OH

I

NH

O

OH O

Rx-ID: 37929266 View in Reaxys 3084/3247

NH Br

X-(CH2)3CCC6H13, X = Cl, Br

N Br

O

O

Rx-ID: 9443960 View in Reaxys 3085/3247

NH Br

Br

N Br

O

O

Rx-ID: 10387812 View in Reaxys 3086/3247

O

O

O NE

NE

Z N

E

N

N

Rx-ID: 39436691 View in Reaxys 3087/3247 O O N O

O

O

O

O

Rx-ID: 6810656 View in Reaxys 3088/3247 O O O

O O

O

O N

O

O

OO

O

Rx-ID: 37282524 View in Reaxys 3089/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

400/428

2016-08-04 14:49:45


O O

O

O

O

O

O

N

N

O

Cl

O

O

OO

O

O

Rx-ID: 37282529 View in Reaxys 3090/3247 O O NH

O Cl

N O

O

O

OO

Rx-ID: 37282532 View in Reaxys 3091/3247

N Cl

O

Rx-ID: 6622353 View in Reaxys 3092/3247

O

OH O N

NH

O

O

NH

NH

O

O

O O

O

O

O

Rx-ID: 3463247 View in Reaxys 3093/3247

O O

OH O

O

O

O NH

NH

NH

NH

O

O

O

O

O

O

Rx-ID: 3463759 View in Reaxys 3094/3247

O O

OH O

S

O

N

NH

NH O

O O

Rx-ID: 19353546 View in Reaxys 3095/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

401/428

2016-08-04 14:49:45


OH O O

O

O

NH

NH

N

O

O

O

O

O

Rx-ID: 19363517 View in Reaxys 3096/3247

O

OH O

O

NH

O NH

NH

NH O

O

OH O

O O

Rx-ID: 19389863 View in Reaxys 3097/3247

O

OH O

O

NH

O

O

NH

NH

O

N

O O

O

O

Rx-ID: 19390168 View in Reaxys 3098/3247

O O

NH

OH O O NH

NH

NH O

O

O

O O

O

O

Rx-ID: 19390329 View in Reaxys 3099/3247

O S

OH O

O

O

O

O

N

NH

NH O

N

O

O

O

O

O

Rx-ID: 19390783 View in Reaxys 3100/3247

O S N

OH O O

O OH

NH

NH NH

O O

OH O

O O

Rx-ID: 19392396 View in Reaxys 3101/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

402/428

2016-08-04 14:49:45


OH O

O S N

O

O

OH

N

NH

NH

O O

O O O

O

Rx-ID: 19392427 View in Reaxys 3102/3247

Si O F F

Si O

O

S

N

O

S

O

O

F

F

N

F

O

O N

F

Rx-ID: 30071325 View in Reaxys 3103/3247

O

NH

NH

O E

O

O

O

Rx-ID: 24238310 View in Reaxys 3104/3247

O

N

O

O

O

O

O

O

E

N

N

O

N

2H

N O

O

O

O

O O

O

Rx-ID: 40567953 View in Reaxys 3105/3247 [Cu(bip)I]2*2CH3COCH3; bip = N,N-bis[(3-indolyl)methyl]N-[(2'-pyridyl)methyl]amine

NH

N

NH

N

NH

NH O

O

N

NH

Rx-ID: 8988716 View in Reaxys 3106/3247 O O

O

O

O

Br

O

O Cl

NH

O O

Rx-ID: 37929278 View in Reaxys 3107/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

403/428

2016-08-04 14:49:45


O

O

O

NH

O

O Br

S S

Br

O

O NH

O

O

O O

Rx-ID: 37929281 View in Reaxys 3108/3247 O

I N

N

O

Rx-ID: 32664141 View in Reaxys 3109/3247

O N NH

NH

N

N

N

N O

N

Rx-ID: 34418872 View in Reaxys 3110/3247 I

NH

O

O

N O

O

O

I

O

O

O

O

Rx-ID: 38205009 View in Reaxys 3111/3247 I

O

NH N O

O

O

Rx-ID: 38205044 View in Reaxys 3112/3247

O

O O

O

O

Cl

O

O

NH

Cl

O

N

O

O Cl

O

O Cl

O

Rx-ID: 5196173 View in Reaxys 3113/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

404/428

2016-08-04 14:49:45


O

O

O

O

O

O

O

O

O

N

NH

O O

O O

Rx-ID: 2022885 View in Reaxys 3114/3247 O

OO

NH

O O

O

OH

O

O

O

O O

O O

NH O

O

O O

Rx-ID: 42642315 View in Reaxys 3115/3247

Cl

I

Cl

N

Br

N

O

O

Rx-ID: 24141526 View in Reaxys 3116/3247

O

NH

NH

O E

O

O

O

Rx-ID: 24239939 View in Reaxys 3117/3247

O O

O

O

N

O

E

O

NH

O

N

NH

O

O

Rx-ID: 24238296 View in Reaxys 3118/3247

Br O

O

N

O

Br

Br

N Br

Br

Br

N

O

O

Rx-ID: 2356673 View in Reaxys 3119/3247

Br

N

Br

N

NH Br

Br Br

Br O

O

O

Rx-ID: 8743590 View in Reaxys 3120/3247

NH

Br

N Br

N

Br O

Rx-ID: 21553388 View in Reaxys 3121/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

405/428

2016-08-04 14:49:45


N

Br

N Br

Br

N

O

Rx-ID: 21553523 View in Reaxys 3122/3247

Br

N

Br

Br

N Br

Br

Br

N

O

Rx-ID: 21561045 View in Reaxys 3123/3247

NH

NH

I

I O

I

O

Rx-ID: 4263983 View in Reaxys 3124/3247

I

I

NH

NH

O

I

O

Rx-ID: 4291604 View in Reaxys 3125/3247

O H 2N

I

NH

N

I

O

Rx-ID: 17964422 View in Reaxys 3126/3247

I

I

NH

NH

I

O

Rx-ID: 17989294 View in Reaxys 3127/3247

I

I

NH

NH

I

O

Rx-ID: 17989318 View in Reaxys 3128/3247

O I

I

NH

N

I

O

Rx-ID: 17989483 View in Reaxys 3129/3247

O

O

O E

O

NH

O

O

O O

NH

O

Rx-ID: 24241479 View in Reaxys 3130/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

406/428

2016-08-04 14:49:45


O

O

O

O

NH

E O NH

O

O

O

O

Rx-ID: 24268177 View in Reaxys 3131/3247

O

O

O

O

E

NH

O

O NH

O

O

O

Rx-ID: 24268180 View in Reaxys 3132/3247 O HO

OH HN

H N

O

O

Rx-ID: 25150886 View in Reaxys 3133/3247

O

O

Cl E

NH

Cl

O NH

O

O

Rx-ID: 24238299 View in Reaxys 3134/3247 O

O

O

NH

N

O

O O

I

O

O I

O

O O

Rx-ID: 4896784 View in Reaxys 3135/3247 Br Br

O

O O

O

O

N O

O

NH

Br

O

O

Br

Rx-ID: 29517194 View in Reaxys 3136/3247 O

Br

NH O

Br

Br

O

O O

O

Br

O

N O

O

Rx-ID: 35470256 View in Reaxys 3137/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

407/428

2016-08-04 14:49:45


O O

Br

O Br

N

Br NH

Br

O

O

Rx-ID: 37754991 View in Reaxys 3138/3247 O

Br

Br

NH

N

Br

Br OH

O

O

O

Rx-ID: 37755005 View in Reaxys 3139/3247 O Br

Br

NH N

Br

Br

O

O

Rx-ID: 37755025 View in Reaxys 3140/3247 O Br

NH

N

Br

O

O

O

O

Rx-ID: 37755051 View in Reaxys 3141/3247

O O

NH O

O

N

O

O

O

N

NH

O

S

E O

N

O

O O

O O

N O

O

Rx-ID: 8673246 View in Reaxys 3142/3247 O

N

O

N

N P O

O

N

Rx-ID: 39665284 View in Reaxys 3143/3247 OH

N

N O

P

N

O

N

N

O

N P O N

O

Rx-ID: 39665285 View in Reaxys 3144/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

408/428

2016-08-04 14:49:45


O

NH

N

O

N

P O N

Rx-ID: 39665286 View in Reaxys 3145/3247 O NH

O

N

N P O

O

N

Rx-ID: 39665288 View in Reaxys 3146/3247

N Cl

O

Rx-ID: 6626859 View in Reaxys 3147/3247

Si

NH

Si

Br

O

N

Cl

Br

O

Rx-ID: 9385435 View in Reaxys 3148/3247

Si

Cl Si N Br

O

Rx-ID: 14076130 View in Reaxys 3149/3247

Si

Cl

N Br

O

Rx-ID: 14076183 View in Reaxys 3150/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

409/428

2016-08-04 14:49:45


F

F

O

O

F

E

NH

F F

O F NH

O

O

Rx-ID: 24268179 View in Reaxys 3151/3247

O

O

NH

E O

O

NH

O

Rx-ID: 24238311 View in Reaxys 3152/3247 O O

O

HN

N

E N H

O

O

O

N

O

Rx-ID: 24238295 View in Reaxys 3153/3247

O

H N

N

N

O

O

NH

E

O O

O

O

Rx-ID: 24238298 View in Reaxys 3154/3247 O O

NH

O

OH

O

Br

O O

O

Br

O NH O

O

O

O O

Rx-ID: 42642313 View in Reaxys 3155/3247

O

O O

NH

NH

S Cl

O

O

O

O S

OH O

NH

O

OH

NH OH

O

O

Rx-ID: 2916167 View in Reaxys 3156/3247

O O

O S

O

O

S

O O

N

NH

NH OH

O

Rx-ID: 19353565 View in Reaxys 3157/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

410/428

2016-08-04 14:49:45


O

O S O

O

O O

O

NH

NH

N OH

O O O

Rx-ID: 19363536 View in Reaxys 3158/3247

O

O S

OH

NH

O

O O

NH

NH

NH

O OH O

OH O

Rx-ID: 19391999 View in Reaxys 3159/3247

O

O S O

NH

OH

O

O

O NH

O

NH

N

OH

O

O

Rx-ID: 19392063 View in Reaxys 3160/3247

O

O

O

O O

NH

NH

O O

O S

O

NH

NH

O

OH

O

O

Rx-ID: 19392328 View in Reaxys 3161/3247

O

O

O S

O

O

O

O O

O NH

NH

NH

NH OH

O O O

O

Rx-ID: 19392372 View in Reaxys 3162/3247

O

S N

O S

O

O O

O O

OH

NH NH

OH

O OH O

NH

O

Rx-ID: 19392409 View in Reaxys 3163/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

411/428

2016-08-04 14:49:45


O

O S N

O S O

O

O O

OH

O

NH

NH

O

N

OH

O

O

Rx-ID: 19392440 View in Reaxys 3164/3247 O

OH

O

O

O

O

O Cl

HO

E

E

E

O

N

O

O

O

NH

O N

N O

N

Rx-ID: 9745759 View in Reaxys 3165/3247

Si Cl

O

NH

O

Si Cl

O

O Cl

Cl

O

N

O

O Cl

O

Rx-ID: 4996939 View in Reaxys 3166/3247

OH H N

H 2N O

H N

N HO

O

O N

N H

O

O

Rx-ID: 25448208 View in Reaxys 3167/3247

O

O NH

N

O

O NH

O O

O O

NH

O

O

NH O O

O

O

Rx-ID: 3345491 View in Reaxys 3168/3247

O

O NH

N

O

O NH

O O

O O

NH

O

O

O

NH O O

O

Rx-ID: 3345492 View in Reaxys 3169/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

412/428

2016-08-04 14:49:45


O O O

O

S

O O

N

NH

NH O O

O

Rx-ID: 19353566 View in Reaxys 3170/3247

O O O

O

S

O O

N

NH

NH O O

O

Rx-ID: 19353567 View in Reaxys 3171/3247

O O

O

O O

O NH

NH

N O

O O

O O

Rx-ID: 19363537 View in Reaxys 3172/3247

O O

O

O O

O NH

NH

N O

O O

O O

Rx-ID: 19363538 View in Reaxys 3173/3247

O NH

OH

O

O O

NH

NH

NH

O OH O

O O O

Rx-ID: 19392000 View in Reaxys 3174/3247

O NH

OH

O

O O

NH

NH

NH

O OH O

O O O

Rx-ID: 19392002 View in Reaxys 3175/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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O

NH

O

OH

O

O

O NH

O

NH

N

O

O

O O

Rx-ID: 19392064 View in Reaxys 3176/3247

O

NH

O

OH

O

O

O NH

O

NH

N

O

O

O O

Rx-ID: 19392067 View in Reaxys 3177/3247

O O S

O O

N

O O

OH

NH

NH

NH

O

O

O

OH O

O

Rx-ID: 19392392 View in Reaxys 3178/3247

O O S

O O

N

O O

OH

NH

NH

NH

O

O

O

OH O

O

Rx-ID: 19392410 View in Reaxys 3179/3247

O

O S

O

O

N

O O

OH

O N

NH

NH

O O O

O

O

Rx-ID: 19392422 View in Reaxys 3180/3247

O

O S N

O

O

O O

OH

O N

O

NH

NH

O O O O

Rx-ID: 19392441 View in Reaxys 3181/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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O

O NH

N

O

O

O

NH

O O

O O

NH O

NH O O

O

O

Rx-ID: 3345485 View in Reaxys 3182/3247

O O O

O

S

O O

N

NH

NH O O

O

Rx-ID: 19353551 View in Reaxys 3183/3247

O O

O

O O

O NH

NH

N O

O O

O O

Rx-ID: 19363522 View in Reaxys 3184/3247

O O O

NH

O

O O

NH

NH

NH

O OH O

O O O

Rx-ID: 19389865 View in Reaxys 3185/3247

O

O

O

O

NH

O O

O

NH

NH

O

N

O O

O O

Rx-ID: 19390171 View in Reaxys 3186/3247

O O S

O

O

O

O NH

O

N O

O

O

N

NH O

O

O O

Rx-ID: 19390787 View in Reaxys 3187/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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O O S

O O

O O

OH

N

NH

NH

NH

O

O

O

OH O

O

Rx-ID: 19392401 View in Reaxys 3188/3247

O

O S

O

N

O O

O

OH

O N

NH

NH

O O O

O

O

Rx-ID: 19392432 View in Reaxys 3189/3247

NH

N

NH

NH

O

O N

O

O

O

N

O

N

O

O

O

Rx-ID: 3344304 View in Reaxys 3190/3247 O O

NH

I

O

I

NH

O O

Rx-ID: 37929255 View in Reaxys 3191/3247 O O

NH

O O

O I

S S

I

NH

O

O

O

O O O

Rx-ID: 37929268 View in Reaxys 3192/3247 O

O

O

O

O

I

O

O Cl

NH

O O

Rx-ID: 37929272 View in Reaxys 3193/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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O O

O

O O

N

O

N O

O O N

O N

O

HO

O

O

Rx-ID: 8709403 View in Reaxys 3194/3247 O Br

Br

NH Si

Br

Cl

N

Br

O

O

O Si

Rx-ID: 35470261 View in Reaxys 3195/3247

N

N

O O

OH

N N N

N

N O

O

O

OH

N

N

N

N

O

N OH

Rx-ID: 1812154 View in Reaxys 3196/3247

NH

O

Sn

Sn

Sn

Br O

NH

Rx-ID: 34022199 View in Reaxys 3197/3247 O

Br

NH Sn Sn

Sn

NH

O

Rx-ID: 34022203 View in Reaxys 3198/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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O

H N

N

N

O

O

NH

E

O

O O

O

O

O

Rx-ID: 7737066 View in Reaxys 3199/3247

O

O

H N

O

N

O E O

O

N

O

O

HN O

Rx-ID: 24238293 View in Reaxys 3200/3247

O

O O

NH

O

N O

O

O

N O

O

O

O N

O

O

O

Rx-ID: 5136996 View in Reaxys 3201/3247 O Br

Br

O

NH O

Br

N

O

Si

Br

O

O

O

O

N O

Si

Rx-ID: 35470258 View in Reaxys 3202/3247

O

O

O

O

O N

O O

O

O

O

O

NH

O O

Si

O

O

Si

Rx-ID: 9587647 View in Reaxys 3203/3247

O O

NH

O Cl

O N

O O

O

O

O

Si

Rx-ID: 13622450 View in Reaxys 3204/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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O O

NH

O O

N

O

O

O

HO

O

O

Si

Rx-ID: 13622537 View in Reaxys 3205/3247

NH

NH

N

O

O

N

O

O

O

Rx-ID: 3238370 View in Reaxys 3206/3247

NH

Li O

N

N O

O

Rx-ID: 19605065 View in Reaxys 3207/3247

O F

O

NH

S

O

O F

F

O N

O

O

O

Rx-ID: 19609583 View in Reaxys 3208/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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NH NH

O

N NH

O

O

Rx-ID: 19609956 View in Reaxys 3209/3247

Si

NH

O N

O

N NH

O

O

Rx-ID: 19614877 View in Reaxys 3210/3247

Si O

NH

O N

O

N NH

O

O

Rx-ID: 19615299 View in Reaxys 3211/3247

Si N

NH

O N N

NH

O

O

O

Rx-ID: 19615542 View in Reaxys 3212/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

420/428

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O Br

O O

Br

OH

N

O O

N

Br

O

N

N

O N

O O

O

N

O N

O

N

O

O

O

Rx-ID: 9674067 View in Reaxys 3213/3247 O Br

OH

O

N

Br

Br

O

N O

O

O

O

O

O

N

N O

N

O

N O

N

O

N O

O

Rx-ID: 9674069 View in Reaxys 3214/3247 Br

O O

N

OH N

O O

O

N

N

O

Rx-ID: 13617468 View in Reaxys 3215/3247 Br

O N O

N O

O

N O

N O

O

Rx-ID: 13629304 View in Reaxys 3216/3247 Br

O N O

N O

O

O

N O

N O

O

Rx-ID: 13629919 View in Reaxys 3217/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

421/428

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Br

O O

O

N

N O

O

N

O

N

O

Rx-ID: 13630682 View in Reaxys 3218/3247 Br

O O

O

N

N O O

O

O

N

N

O

Rx-ID: 13632120 View in Reaxys 3219/3247

O

O

O

O

O O

NH

NH

S Cl

O S

OH O

NH

O

O

NH O

O

O

O

O

Rx-ID: 2916114 View in Reaxys 3220/3247

O O

O S

O

O

S

O O

N

NH

NH O O

O

Rx-ID: 19353552 View in Reaxys 3221/3247

O

O S O

O

O O

O

NH

NH

N O

O O

O O

Rx-ID: 19363523 View in Reaxys 3222/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

422/428

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O O

O S

O

NH

O

O O

NH

NH

NH

O OH O

O O O

Rx-ID: 19389866 View in Reaxys 3223/3247

O

O S

O

O

O

NH

O O

O

NH

NH

O

N

O O

O O

Rx-ID: 19390172 View in Reaxys 3224/3247

O

O

O S

O

NH

O NH

O O

O O

NH

NH

O

O O

O

O

Rx-ID: 19390331 View in Reaxys 3225/3247

O O

O

N

NH

O O

O

NH

O

O O

O S

NH O

O

O O

Rx-ID: 19390352 View in Reaxys 3226/3247

O

O

O S

O

O

O

O O

O NH

NH

NH

NH O

O

O

O O

O

Rx-ID: 19390520 View in Reaxys 3227/3247

O O S

O S O

O

O

O NH

O

N O

O

O

N

NH O

O

O O

Rx-ID: 19390788 View in Reaxys 3228/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

423/428

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O

S

O S

O

O O

N

O O

OH

NH

NH

NH

O

O

O

OH O

O

Rx-ID: 19392402 View in Reaxys 3229/3247

O

S

O

O

N

O S

O

O O

OH

O N

NH

NH

O O O

O

O

Rx-ID: 19392433 View in Reaxys 3230/3247

O

O

N

O

O

N O

Z

O O

O

O

O NH

O N

O

O

O

Rx-ID: 8932328 View in Reaxys 3231/3247 O

O N

N N

N

O

O

P

O O

N

O

O

O P N

N

OH

Rx-ID: 39200920 View in Reaxys 3232/3247 O

N

HO

O

O

O

OH

O

O

O P N

N

Rx-ID: 39200926 View in Reaxys 3233/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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O

N HO O

O

O O

O

O

O

P N

N

Rx-ID: 39200935 View in Reaxys 3234/3247 O

N

O

O

O O O

O Br

O P N

N

Rx-ID: 39200938 View in Reaxys 3235/3247

O

O

N

N O

O O

O

O

O

O P N

N

Rx-ID: 39200940 View in Reaxys 3236/3247 O

N

NH

O O

O

O P N

N

Rx-ID: 39200946 View in Reaxys 3237/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

425/428

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O

N NH

O O O

O

O

P N

N

Rx-ID: 39200955 View in Reaxys 3238/3247

O

O O

NH O

N O

O

N O

O

O N

O

O

N

O

O

O O

O

N O

O

Rx-ID: 8673245 View in Reaxys 3239/3247

N

N

O

O

N

O H

O

O H

O

O

H

O

H

O O H

O H O O

O H O

O O H

O

OO O

O

Rx-ID: 9333300 View in Reaxys 3240/3247

NH

O

Tl

O

O

F

F O

F F

O

F F

Rx-ID: 5662445 View in Reaxys 3241/3247 O

Br

Br

O

N

OH N

O

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

426/428

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O

Br N O

O O

N

O

O

O

N

N O O

O

N

N

O O

Rx-ID: 9646052 View in Reaxys 3242/3247 OH N

Br

Br

O

N O

O O

O N

Br

O

N O

O N O

O

N

N

O

O

O

N O

O

Rx-ID: 9646053 View in Reaxys 3243/3247

N

O

Tl O

F

O

O

F

F

O

F

F

F

Rx-ID: 5663973 View in Reaxys 3244/3247

NH

O

Tl O

F F

O

O

F

F

O

F F

Rx-ID: 5665426 View in Reaxys 3245/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

427/428

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N

O

Tl O

F

O

O

F

F

O

F

F

F

Rx-ID: 5664877 View in Reaxys 3246/3247 NH

NH

N E

N

N

E

N

HI

HI

O

O NH

NH

Br

Br

2 HI

NH

Br

2 HI

NH

2 HI

NH O

O N N

HN O

T-4 T-4

N

T-4

T-4

O

N

NH

N

N

HN

NH

N

T-4 T-4

N

N

NH

N

HN

T-4 T-4

N

O

T-4

T-4

N

NH

O

O HN

HN

Br

racemate

HN

Rx-ID: 38313148 View in Reaxys 3247/3247

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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