benzo[d][1,3]dioxole by Asch

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Date

10 substances in Reaxys

2016-08-05 15h:42m:34s (EST)

6 substances in Reaxys

2016-08-05 15h:44m:29s (EST)

1. Query O

Search as: As drawn, No mixtures, No charges, No radicals 2. Query

(1. Query) AND NOT itemno in (8,6,4,3)

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2016-08-05 15:49:11

Reaxys ID 115506 View in Reaxys

1/6 CAS Registry Number: 274-09-9 Chemical Name: Methylenedioxybenzene; 1,3-Benzodioxole; 1,3-benzodioxole Linear Structure Formula: C7H6O2 Molecular Formula: C7H6O2 Molecular Weight: 122.123 Type of Substance: heterocyclic InChI Key: FTNJQNQLEGKTGD-UHFFFAOYSA-N Note:

O O

Substance Label (73) Label References 2a

Xi, Yumeng; Su, Yijin; Dong, Boliang; McClain, Edward J.; Shi, Xiaodong; Yu, Zhaoyuan; Lan, Yu; Angewandte Chemie, International Edition; vol. 53; nb. 37; (2014); p. 9817 - 9821,5; Angewandte Chemie; vol. 126; nb. 37; (2014); p. 9975 - 9979,5, View in Reaxys; Murphy, John J.; Bastida, David; Paria, Suva; Fagnoni, Maurizio; Melchiorre, Paolo; Nature; vol. 532; nb. 7598; (2016); p. 218 - 222, View in Reaxys

Chang, Meng-Yang; Cheng, Yu-Chieh; Organic Letters; vol. 18; nb. 3; (2016); p. 608 - 611, View in Reaxys

Bergami, Matteo; Protti, Stefano; Ravelli, Davide; Fagnoni, Maurizio; Advanced Synthesis and Catalysis; vol. 358; nb. 7; (2016); p. 1164 - 1172, View in Reaxys

Nu-H

Gorbunov, Evgeny B.; Rusinov, Gennady L.; Ulomsky, Evgeny N.; Rusinov, Vladimir L.; Charushin, Valery N.; Chupakhin, Oleg N.; Tetrahedron Letters; vol. 57; nb. 21; (2016); p. 2303 - 2305, View in Reaxys

Chang, Meng-Yang; Huang, Yi-Hsuan; Wang, Heui-Sin; Tetrahedron; vol. 72; nb. 22; (2016); p. 3022 3031, View in Reaxys

Yadav; Reddy; Basak; Narsaiah; Advanced Synthesis and Catalysis; vol. 346; nb. 1; (2004); p. 77 - 82, View in Reaxys; Yang, Yu-Dong; Iwamoto, Kanji; Tokunaga, Etsuko; Shibata, Norio; Chemical Communications; vol. 49; nb. 48; (2013); p. 5510 - 5512, View in Reaxys; Xing, Siyang; Ren, Jing; Wang, Kui; Cui, Hong; Li, Wenrui; Yan, Han; Tetrahedron; vol. 71; nb. 36; (2015); p. 6290 - 6299; Art.No: 26848, View in Reaxys

Ianni, Alen; Waldvogel, Siegfried R.; Synthesis; nb. 13; (2006); p. 2103 - 2112, View in Reaxys; Ryu, Ilhyong; Tani, Akihiro; Fukuyama, Takahide; Ravelli, Davide; Montanaro, Sara; Fagnoni, Maurizio; Organic Letters; vol. 15; nb. 10; (2013); p. 2554 - 2557, View in Reaxys; Morizur, Vincent; Szafranek, Jessica; Bonhomme, Dominique; Olivero, Sandra; Desmurs, Jean Roger; Duach, Elisabet; Tetrahedron; vol. 71; nb. 38; (2015); p. 6813 - 6817, View in Reaxys

Regenbrecht, Carolin; Waldvogel, Siegfried R.; Beilstein Journal of Organic Chemistry; vol. 8; (2012); p. 1721 - 1724,4, View in Reaxys; Belhomme, Marie-Charlotte; Bayle, Alexandre; Poisson, Thomas; Pannecoucke, Xavier; European Journal of Organic Chemistry; vol. 2015; nb. 8; (2015); p. 1719 - 1726, View in Reaxys

Gigant, Nicolas; Baeckvall, Jan-E.; Chemistry - A European Journal; vol. 20; nb. 20; (2014); p. 5890 5894, View in Reaxys; Gu, Lijun; Jin, Cheng; Liu, Jiyan; Green Chemistry; vol. 17; nb. 7; (2015); p. 3733 3736, View in Reaxys; Qian, Ping; Du, Bingnan; Zhou, Jie; Mei, Haibo; Han, Jianlin; Pan, Yi; RSC Advances; vol. 5; nb. 80; (2015); p. 64961 - 64965, View in Reaxys

Chu, Xue-Qiang; Meng, Hua; Zi, You; Xu, Xiao-Ping; Ji, Shun-Jun; Chemical Communications; vol. 50; nb. 68; (2014); p. 9718 - 9721, View in Reaxys; Shin, Seohyun; Park, Youngchul; Kim, Cheol-Eui; Son, Jeong-Yu; Lee, Phil Ho; Journal of Organic Chemistry; vol. 80; nb. 11; (2015); p. 5859 - 5869, View in Reaxys

Varun, Begur Vasanthkumar; Prabhu, Kandikere Ramaiah; Journal of Organic Chemistry; vol. 79; nb. 20; (2014); p. 9655 - 9668, View in Reaxys; Wang, Jian; Chen, Shu-Bin; Wang, Shu-Guang; Li, Jing-Hua; Australian Journal of Chemistry; vol. 68; nb. 3; (2015); p. 513 - 517, View in Reaxys

More, Nagnath Yadav; Jeganmohan, Masilamani; Chemistry - A European Journal; vol. 21; nb. 3; (2015); p. 1337 - 1342, View in Reaxys

28r

Aksenov, Alexander V.; Smirnov, Alexander N.; Aksenov, Nicolai A.; Aksenova, Inna V.; Matheny, Jonathon P.; Rubin, Michael; RSC Advances; vol. 5; nb. 12; (2015); p. 8647 - 8656, View in Reaxys

Tamura, Toshiyuki; Moriyama, Katsuhiko; Togo, Hideo; European Journal of Organic Chemistry; vol. 2015; nb. 9; (2015); p. 2023 - 2029, View in Reaxys

Zhou, Wei; Qian, Ping; Zhao, Jincan; Fang, Hong; Han, Jianlin; Pan, Yi; Organic Letters; vol. 17; nb. 5; (2015); p. 1160 - 1163, View in Reaxys

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10a

Asquith, Christopher R.M.; Meli, Marina L.; Konstantinova, Lidia S.; Laitinen, Tuomo; Poso, Antti; Rakitin, Oleg A.; Hofmann-Lehmann, Regina; Allenspach, Karin; Hilton, Stephen T.; Bioorganic and Medicinal Chemistry Letters; vol. 25; nb. 6; (2015); p. 1352 - 1355, View in Reaxys

Koura, Minoru; Matsuda, Takayuki; Okuda, Ayumu; Watanabe, Yuichiro; Yamaguchi, Yuki; Kurobuchi, Sayaka; Matsumoto, Yuuki; Shibuya, Kimiyuki; Bioorganic and Medicinal Chemistry Letters; vol. 25; nb. 13; (2015); p. 2668 - 2674, View in Reaxys

Selvi, Thangavel; Srinivasan, Kannupal; Advanced Synthesis and Catalysis; vol. 357; nb. 9; (2015); p. 2111 - 2118, View in Reaxys

S1; 1

Eliasen, Anders M.; Christy, Mitchell; Claussen, Karin R.; Besandre, Ronald; Thedford, Randal P.; Siegel, Dionicio; Organic Letters; vol. 17; nb. 18; (2015); p. 4420 - 4423, View in Reaxys

Jouvin, Kvin; Matheis, Christian; Goossen, Lukas J.; Chemistry - A European Journal; vol. 21; nb. 41; (2015); p. 14324 - 14327, View in Reaxys

1i; 1j

Bonassi, Filippo; Ravelli, Davide; Protti, Stefano; Fagnoni, Maurizio; Advanced Synthesis and Catalysis; vol. 357; nb. 16-17; (2015); p. 3687 - 3695, View in Reaxys

Wu, Maojiang; Sun, Qiming; Yang, Chunhao; Chen, Dongdong; Ding, Jian; Chen, Yi; Lin, Liping; Xie, Yuyuan; Bioorganic and Medicinal Chemistry Letters; vol. 17; nb. 4; (2007); p. 869 - 873, View in Reaxys; Zhang, Ruo-Yi; Xi, Long-Yi; Zhang, Lei; Liang, Shuai; Chen, Shan-Yong; Yu, Xiao-Qi; RSC Advances; vol. 4; nb. 97; (2014); p. 54349 - 54353, View in Reaxys

Uchida, Mihoko; Nakajin, Shizuo; Toyoshima, Satoshi; Shinoda, Masato; Biological and Pharmaceutical Bulletin; vol. 19; nb. 4; (1996); p. 623 - 626, View in Reaxys; Patent; Ube Industries, Ltd.; EP2119713; (2009); (A1) English, View in Reaxys; Patent; Ube Industries, Ltd.; EP2119714; (2009); (A1) English, View in Reaxys; Pinalli, Roberta; Barboza, Tahnee; Bianchi, Federica; Massera, Chiara; Ugozzoli, Franco; Dalcanale, Enrico; Supramolecular Chemistry; vol. 25; nb. 9-11; (2013); p. 682 - 687, View in Reaxys; Umesha, Basavaiah; Basavaraju, Yeriyur Basavaiah; Medicinal Chemistry Research; vol. 23; nb. 8; (2014); p. 3744 - 3751, View in Reaxys; Jung, Jaehun; Kim, Eunjin; You, Youngmin; Cho, Eun Jin; Advanced Synthesis and Catalysis; vol. 356; nb. 13; (2014); p. 2741 - 2748, View in Reaxys

More, Nagnath Yadav; Jeganmohan, Masilamani; Organic Letters; vol. 16; nb. 3; (2014); p. 804 - 807, View in Reaxys

26a

Chen, Cheng; Hartwig, John F.; Science; vol. 343; nb. 6173; (2014); p. 853 - 857, View in Reaxys

Reddel, Jordan C. T.; Lutz, Kelly E.; Diagne, Abdallah B.; Thomson, Regan J.; Angewandte Chemie International Edition; vol. 53; nb. 5; (2014); p. 1395 - 1398; Angew. Chem.; vol. 126; nb. 05; (2014); p. 1419 1422,4, View in Reaxys

Gigant, Nicolas; Baeckvall, Jan-E.; Organic Letters; vol. 16; nb. 6; (2014); p. 1664 - 1667, View in Reaxys

Rafiq, Settu Muhamad; Sivasakthikumaran, Ramakrishnan; Mohanakrishnan, Arasambattu K.; Organic Letters; vol. 16; nb. 10; (2014); p. 2720 - 2723, View in Reaxys

Maibunkaew, Tapanee; Thongsornkleeb, Charnsak; Tummatorn, Jumreang; Bunrit, Anon; Ruchirawat, Somsak; Synlett; vol. 25; nb. 12; (2014); p. 1769 - 1775; Art.No: ST-2014-U0267-L, View in Reaxys

Guo, Shi-Huan; Xing, Sheng-Zhu; Mao, Shuai; Gao, Ya-Ru; Chen, Wen-Liang; Wang, Yong-Qiang; Tetrahedron Letters; vol. 55; nb. 49; (2014); p. 6718 - 6720, View in Reaxys

12a

Ma, Ran; Huang, Cheng-Bin; Liu, An-Hua; Li, Xue-Dong; He, Liang-Nian; Catalysis Science and Technology; vol. 4; nb. 12; (2014); p. 4308 - 4312, View in Reaxys

32'

Shrestha, Ruja; Dorn, Stephanie C. M.; Weix, Daniel J.; Journal of the American Chemical Society; vol. 135; nb. 2; (2013); p. 751 - 762, View in Reaxys

11a

Liu, An-Hua; Ma, Ran; Zhang, Meng; He, Liang-Nian; Catalysis Today; vol. 194; nb. 1; (2012); p. 38 - 43, View in Reaxys

Gavara, Laurent; Boisse, Thomas; Rigo, Benoit; Henichart, Jean-Pierre; Tetrahedron; vol. 64; nb. 22; (2008); p. 4999 - 5004, View in Reaxys

Yadav, Jhillu S.; Reddy, Basi V. Subba; Rao, R. Srinivasa; Kumar, S. Praveen; Nagaiah; Synlett; nb. 5; (2002); p. 784 - 786, View in Reaxys; Wang, Zhiyong; Sun, Xiaoyu; Wu, Jie; Tetrahedron; vol. 64; nb. 22; (2008); p. 5013 - 5018, View in Reaxys

Compound 0106; 0106

Patent; Cai, Xiong; Qian, Changgeng; Zhai, Haixiao; US2008/234314; (2008); (A1) English, View in Reaxys

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Kooistra, Floris B.; Knol, Joop; Kastenberg, Fredrik; Popescu, Lacramioara M.; Verhees, Wiljan J. H.; Kroon, Jan M.; Hummelen, Jan C.; Organic Letters; vol. 9; nb. 4; (2007); p. 551 - 554, View in Reaxys

Table 2, entry 3

Amijs, Catelijne H. M.; Ferrer, Catalina; Echavarren, Antonio M.; Chemical Communications; nb. 7; (2007); p. 698 - 700, View in Reaxys

educt to 11g

Lafrance, Marc; Blaquiere, Nicole; Fagnou, Keith; European Journal of Organic Chemistry; nb. 5; (2007); p. 811 - 825, View in Reaxys

educt to 3ag

Chu, Cheng-Ming; Huang, Wan-Ju; Liu, Ju-Tsung; Yao, Ching-Fa; Tetrahedron Letters; vol. 48; nb. 39; (2007); p. 6881 - 6885, View in Reaxys

Banwell, Martin G.; Kokas, Okanya J.; Willis, Anthony C.; Organic Letters; vol. 9; nb. 18; (2007); p. 3503 3506, View in Reaxys; Bjorsvik, Hans-Rene; Liguori, Lucia; Minisci, Francesco; Organic Process Research and Development; vol. 4; nb. 6; (2000); p. 534 - 543, View in Reaxys

Sun, Xiaoyu; Sun, Wei; Fan, Renhua; Wu, Jie; Advanced Synthesis and Catalysis; vol. 349; nb. 13; (2007); p. 2151 - 2155, View in Reaxys

1/6, 4/4

Onoue, Ken-Ichi; Shintou, Taichi; Zhang, Chang Shan; Itoh, Isamu; Chemistry Letters; vol. 35; nb. 1; (2006); p. 22 - 23, View in Reaxys

Esumi, Tomoyuki; Hojyo, Daisuke; Zhai, Haifeng; Fukuyama, Yoshiyasu; Tetrahedron Letters; vol. 47; nb. 24; (2006); p. 3979 - 3983, View in Reaxys

Tab. 2, entry 3

Zhang, Guofu; Liu, Renhua; Xu, Qing; Ma, Lixin; Liang, Xinmiao; Advanced Synthesis and Catalysis; vol. 348; nb. 7-8; (2006); p. 862 - 866, View in Reaxys

Steinke, Nelli; Frey, Wolfgang; Baro, Angelika; Laschat, Sabine; Drees, Christina; Nimtz, Manfred; Haegele, Constanze; Giesselmann, Frank; Chemistry - A European Journal; vol. 12; nb. 4; (2006); p. 1026 - 1035, View in Reaxys

BDO

Pietraperzia; Zoppi; Becucci; Droghetti; Castellucci; Chemical Physics Letters; vol. 385; nb. 3-4; (2004); p. 304 - 308, View in Reaxys; He, Yonggang; Wu, Chengyin; Kong, Wei; Chemical Physics Letters; vol. 402; nb. 1-3; (2005); p. 212 - 216, View in Reaxys; Kisiel, Zbigniew; Pszczolkowski, Lech; Pietraperzia; Becucci; Caminati; Meyer, Rolf; Physical Chemistry Chemical Physics; vol. 6; nb. 24; (2004); p. 5469 5475, View in Reaxys

1,2(OCH2O)C6H4

Goldoni, Luca; Cravotto, Giancarlo; Penoni, Andrea; Tollari, Stefano; Palmisano, Giovanni; Synlett; nb. 6; (2005); p. 927 - 930; Art.No: G03605ST, View in Reaxys

Yamada, Tomoyuki; Sakaguchi, Satoshi; Ishii, Yasutaka; Journal of Organic Chemistry; vol. 70; nb. 14; (2005); p. 5471 - 5474, View in Reaxys

t.1, arene, entry e

Bandgar; Makone; Synthetic Communications; vol. 34; nb. 4; (2004); p. 743 - 750, View in Reaxys

subs., Tab. 1, entry 3

Braddock, D. Christopher; Cansell, Gemma; Hermitage, Stephen A.; Synlett; nb. 3; (2004); p. 461 - 464, View in Reaxys

Tani, Masayuki; Sakaguchi, Satoshi; Ishii, Yasutaka; Journal of Organic Chemistry; vol. 69; nb. 4; (2004); p. 1221 - 1226, View in Reaxys

substr., Tab.1, en- Branytska, Oiena; Neumann, Ronny; Synlett; nb. 9; (2004); p. 1575 - 1576, View in Reaxys try 6 Tab.1.col.2. run 6

Krishna Mohan; Narender; Kulkarni; Tetrahedron Letters; vol. 45; nb. 43; (2004); p. 8015 - 8018, View in Reaxys

Cabiddu, Maria Grazia; Cadoni, Enzo; De Montis, Stefania; Fattuoni, Claudia; Melis, Stefana; Usai, Michele; Tetrahedron; vol. 59; nb. 24; (2003); p. 4383 - 4387, View in Reaxys

Tsukada, Naofumi; Yagura, Yasushige; Sato, Tetsuo; Inoue, Yoshio; Synlett; nb. 10; (2003); p. 1431 1434, View in Reaxys

Basavaraju; Anjanamurthy; Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry; vol. 42; nb. 4; (2003); p. 876 - 880, View in Reaxys

BZD

Laane; Sakurai; Klots; Meinander; Morris; Chiang; Bondoc; Journal of Molecular Structure; vol. 480-481; (1999); p. 189 - 196, View in Reaxys; Jeon, Sangmi; Choo, Jaebum; Kim, Sungwhan; Kwon, Younghi; Kim, Jin-Yeol; Lee, Young-Il; Chung, Hoeil; Journal of Molecular Structure; vol. 609; nb. 1-3; (2002); p. 159 - 167, View in Reaxys

tab1 arene ent.h

Yadav; Reddy; Veerendhar; Srinivasa Rao; Nagaiah; Chemistry Letters; nb. 3; (2002); p. 318 - 319, View in Reaxys

substr., T.1, e.4

Roy, Subhas Chandra; Guin, Chandrani; Rana, Kalyan Kumar; Maiti, Gourhari; Tetrahedron Letters; vol. 42; nb. 39; (2001); p. 6941 - 6942, View in Reaxys

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Dastan, Arif; Saracoglu, Nurullah; Balci, Metin; European Journal of Organic Chemistry; nb. 18; (2001); p. 3519 - 3522, View in Reaxys

Tab., entry e, arene

Yadav; Subba Reddy; Mahesh Kumar; Madan; Synlett; nb. 11; (2001); p. 1781 - 1783, View in Reaxys

educt 3d,j (Table 1)

Yadav; Subba Reddy; Rao, R. Srinivasa; Veerendhar; Nagaiah; Tetrahedron Letters; vol. 42; nb. 45; (2001); p. 8067 - 8070, View in Reaxys

3, R=1,2-methyle- Manoso; DeShong; Journal of Organic Chemistry; vol. 66; nb. 22; (2001); p. 7449 - 7455, View in Reaxys nedioxy I

Laane; Bondoc; Sakurai; Morris; Meinander; Choo; Journal of the American Chemical Society; vol. 122; nb. 11; (2000); p. 2628 - 2634, View in Reaxys

Gevorgyan, Vladimir; Rubin, Michael; Benson, Sharonda; Liu, Jian-Xiu; Yamamoto, Yoshinori; Journal of Organic Chemistry; vol. 65; nb. 19; (2000); p. 6179 - 6186, View in Reaxys

educt to 3a

Bensel, Nicolas; Pevere, Virginie; Desmurs, Jean Roger; Wagner, Alain; Mioskowski, Charles; Tetrahedron Letters; vol. 40; nb. 5; (1999); p. 879 - 882, View in Reaxys

Malkov, Andrei V.; Davis, Stuart L.; Baxendale, Ian R.; Mitchell, William L.; Kocovsky, Pavel; Journal of Organic Chemistry; vol. 64; nb. 8; (1999); p. 2751 - 2764, View in Reaxys

arene (Tab. 1, run Watanabe, Makoto; Nishiyama, Masakazu; Koie, Yasuyuki; Tetrahedron Letters; vol. 40; nb. 50; (1999); p. 10) 8837 - 8840, View in Reaxys C&0%-MDB

Sidhu; Marcus; Parkinson; Omiecinski; Journal of biochemical and molecular toxicology; vol. 12; nb. 5; (1998); p. 253 - 262, View in Reaxys

Rudenko; Pragst; Russian Journal of Organic Chemistry; vol. 34; nb. 11; (1998); p. 1589 - 1626, View in Reaxys

Figure 1 BD

Sinal; Bend; Chemical Research in Toxicology; vol. 8; nb. 1; (1995); p. 82 - 91, View in Reaxys

Patent-Specific Data (8) Prophetic ComLocation in Patent References pound Page/Page column

Patent; BIOENERGENIX; McCall, John M.; Romero, Donna L.; US2014/128392; (2014); (A1) English, View in Reaxys; Patent; Dow AgroSciences LLC; Eckelbarger, Joseph D.; Epp, Jeffrey B.; Fischer, Lindsey G.; Lowe, Christian T.; Petkus, Jeff; Roth, Joshua; Satchivi, Norbert M.; Schmitzer, Paul R.; Siddall, Thomas L.; US2014/274701; (2014); (A1) English, View in Reaxys; Patent; ENDURA S.P.A.; Gobbi, Carlotta; Borzatta, Valerio; Capparella, Elisa; US2015/38465; (2015); (A1) English, View in Reaxys Patent; THE REGENTS OF UNIVERSITY OF CALIFORNIA; HARTWIG, John, F.; CHENG, Chen; WILSON, Tyler; WO2015/35325; (2015); (A1) English, View in Reaxys

prophetic product

Patent; Hoffmann-La Roche Inc.; US4143227; (1979); (A1) English, View in Reaxys; Patent; Shasun Pharma Solutions Limited; US2008/154049; (2008); (A1) English, View in Reaxys Patent; UBE INDUSTRIES, LTD.; WO2007/20964; (2007); (A1) Japanese, View in Reaxys Patent; MITENI S.p.A.; EP1502908; (2005); (A1) English, View in Reaxys Patent; Endura S.p.A.; US6342613; (2002); (B1) English, View in Reaxys Patent; The Jordanian Pharmaceutical Manufacturing and Medical Equipment Co.Ltd.; EP1219614; (2002); (A1) English, View in Reaxys

prophetic product

Claim

Derivative (1) Comment (Derivative)

References

Charge-Transfer Absorptionsbanden mit div. π-Acceptoren

Patent; Warner-Lambert Company; US6177423; (2001); (B1) English, View in Reaxys

Zweig et al.; Journal of the American Chemical Society; vol. 85; (1963); p. 3933, View in Reaxys

Melting Point (3) 1 of 3

Melting Point [°C]

112

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Duckett et al.; Chemical Physics Letters; vol. 64; (1979); p. 261, View in Reaxys 2 of 3

Melting Point [°C]

Solvent (Melting Point)

methanol

Dyke,S.F.; Tiley,E.P.; Tetrahedron; vol. 31; (1975); p. 561 - 568, View in Reaxys 3 of 3

Melting Point [°C]

-18

Baker; Field; Journal of the Chemical Society; (1932); p. 86,87, View in Reaxys Boiling Point (18) Boiling Point [°C] Pressure (Boiling Point) [Torr] 65 - 66

Comment (Boiling References Point)

Cabiddu, Maria Grazia; Cadoni, Enzo; De Montis, Stefania; Fattuoni, Claudia; Melis, Stefana; Usai, Michele; Tetrahedron; vol. 59; nb. 24; (2003); p. 4383 - 4387, View in Reaxys

173 - 175

Yagupol'skii,L.M. et al.; J. Gen. Chem. USSR (Engl. Transl.); vol. 34; nb. 1; (1964); p. 307 - 317,304 - 312, View in Reaxys; Dallacker; Binsack; Monatshefte fuer Chemie; vol. 92; (1961); p. 492, View in Reaxys; Azafonov, N. E.; Sedishev, I. P.; Zhulin, V. M.; Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation); vol. 39; nb. 4.1; (1990); p. 738 - 741; Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya; nb. 4; (1990); p. 829 - 832, View in Reaxys

174 - 176

Sokolovskii, A. V.; Nazarov, D. V.; Rol'nik, L. Z.; Zlot-skii, S. S.; Rakhmankulov, D. L.; J. Gen. Chem. USSR (Engl. Transl.); vol. 58; nb. 6; (1988); p. 1305 - 1308,1159 - 1162, View in Reaxys

151

0.5

Castillo, P.; Rodriguez-Ubis, J. C.; Rodriguez, F.; Synthesis; nb. 10; (1986); p. 839 - 840, View in Reaxys

45 - 47

Wilkinson et al.; Journal of Agricultural and Food Chemistry; vol. 14; (1966); p. 73,74, View in Reaxys

Normant; Feugeas; Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences; vol. 258; (1964); p. 2846, View in Reaxys

172 - 173

Perkin; Robinson; Thomas; Journal of the Chemical Society; vol. 95; (1909); p. 1979, View in Reaxys; Moureu; Bulletin de la Societe Chimique de France; vol. <3> 15; (1896); p. 655; Annales de Chimie (Cachan, France); vol. <7> 18; (1899); p. 104, View in Reaxys; Ghosh; Journal of the Chemical Society; vol. 107; (1915); p. 1595, View in Reaxys; Baddeley et al.; Journal of the Chemical Society; (1961); p. 2516,2517, View in Reaxys

57 - 58

Dallacker; Binsack; Monatshefte fuer Chemie; vol. 92; (1961); p. 492, View in Reaxys

74 - 75

Laskina; Dewizkaja; J. Appl. Chem. USSR (Engl. Transl.); vol. 34; (1961); p. 2338,2214; Chem.Abstr.; nb. 8611; (1962), View in Reaxys

71 - 72

Gensler et al.; Journal of the American Chemical Society; vol. 82; (1960); p. 1714,1724, View in Reaxys

Laskina; Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation); vol. 32; (1959); p. 878,880; engl. Ausg. S. 895, 897, View in Reaxys

173.2 - 173.5

758

Cass et al.; Journal of the Chemical Society; (1958); p. 2595, View in Reaxys

77.5

Gensler; Samour; Journal of Organic Chemistry; vol. 18; (1953); p. 9,13, View in Reaxys

57.2

Brown; Wilzbach; Urry; Canadian Journal of Research, Section B: Chemical Sciences; vol. 27; (1949); p. 398,403, View in Reaxys

Mottier; Arch. Sci. phys. nat.; vol. 17; (1935); p. 289, View in Reaxys

171

755.5

Hillmer; Schorning; Zeitschrift fuer Physikalische Chemie (Leipzig); vol. <A> 167; (1934); p. 407,414, 415; Zeitschrift fuer Physikalische

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Chemie (Leipzig); vol. <A> 168; (1934); p. 81,101, 102, View in Reaxys 55 - 56

Mosettig; Jovanovic; Monatshefte fuer Chemie; vol. 53/54; (1929); p. 435, View in Reaxys

175

Oel.

Sonn; Benirschke; Chemische Berichte; vol. 54; (1921); p. 1732, View in Reaxys

Refractive Index (8) Refractive Index Wavelength (Refractive Index) [nm]

Temperature (Refractive Index) [°C]

References

1.5385

589

Laskina; Dewizkaja; J. Appl. Chem. USSR (Engl. Transl.); vol. 34; (1961); p. 2338,2214; Chem.Abstr.; nb. 8611; (1962), View in Reaxys; Sokolovskii, A. V.; Nazarov, D. V.; Rol'nik, L. Z.; Zlot-skii, S. S.; Rakhmankulov, D. L.; J. Gen. Chem. USSR (Engl. Transl.); vol. 58; nb. 6; (1988); p. 1305 - 1308,1159 - 1162, View in Reaxys

1.537

589

Wilkinson et al.; Journal of Agricultural and Food Chemistry; vol. 14; (1966); p. 73,74, View in Reaxys

1.539

589

Normant; Feugeas; Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences; vol. 258; (1964); p. 2846, View in Reaxys

1.536

589

Gensler et al.; Journal of the American Chemical Society; vol. 82; (1960); p. 1714,1724, View in Reaxys

1.54

589

Laskina; Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation); vol. 32; (1959); p. 878,880; engl. Ausg. S. 895, 897, View in Reaxys

1.5382

589

Brown; Wilzbach; Urry; Canadian Journal of Research, Section B: Chemical Sciences; vol. 27; (1949); p. 398,403, View in Reaxys

1.5387

589

Mottier; Arch. Sci. phys. nat.; vol. 17; (1935); p. 289, View in Reaxys

1.5423

589

Mosettig; Jovanovic; Monatshefte fuer Chemie; vol. 53/54; (1929); p. 435, View in Reaxys

Density (6) 1 of 6

Density [g·cm-3]

1.16

Reference Temperature [°C]

Measurement Temperature [°C]

Sokolovskii, A. V.; Nazarov, D. V.; Rol'nik, L. Z.; Zlot-skii, S. S.; Rakhmankulov, D. L.; J. Gen. Chem. USSR (Engl. Transl.); vol. 58; nb. 6; (1988); p. 1305 - 1308,1159 - 1162, View in Reaxys 2 of 6

Density [g·cm-3]

1.1972

Reference Temperature [°C]

Measurement Temperature [°C]

Laskina; Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation); vol. 32; (1959); p. 878,880; engl. Ausg. S. 895, 897, View in Reaxys 3 of 6

Density [g·cm-3]

1.064

Reference Temperature [°C]

Measurement Temperature [°C]

Brown; Wilzbach; Urry; Canadian Journal of Research, Section B: Chemical Sciences; vol. 27; (1949); p. 398,403, View in Reaxys 4 of 6

Density [g·cm-3]

1.185

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Reference Temperature [°C]

Measurement Temperature [°C]

Mottier; Arch. Sci. phys. nat.; vol. 17; (1935); p. 289, View in Reaxys 5 of 6

Density [g·cm-3]

1.064

Reference Temperature [°C]

Measurement Temperature [°C]

Ghosh; Journal of the Chemical Society; vol. 107; (1915); p. 1595, View in Reaxys 6 of 6

Density [g·cm-3]

1.202

Measurement Temperature [°C]

Description (Association Association with compound (MCS)) Solvent (Association (MCS))

phosphate buffer; water-d2; water; dimethylsulfoxide-d6

Temperature (Association (MCS)) [°C]

Partner (Association (MCS))

Bcl-xL protein

Barelier, Sarah; Pons, Julien; Marcillat, Olivier; Lancelin, Jean-Marc; Krimm, Isabelle; Journal of Medicinal Chemistry; vol. 53; nb. 6; (2010); p. 2577 - 2588, View in Reaxys 2 of 9

Description (Association UV/VIS spectrum of the complex (MCS)) Solvent (Association (MCS))

CH2Cl2

Temperature (Association (MCS)) [°C]

Partner (Association (MCS))

ethenetetracarbonitrile

Frey, John E.; Aiello, Theresa; Beaman, Douglas N.; Combs, Scott D.; Fu, Shi-lin; Puckett, Jeffrey J.; Journal of Organic Chemistry; vol. 59; nb. 7; (1994); p. 1817 - 1830, View in Reaxys 3 of 9

Description (Association Stability constant of the complex with ... (MCS)) Solvent (Association (MCS))

CH2Cl2

Temperature (Association (MCS)) [°C]

Partner (Association (MCS))

ethenetetracarbonitrile

Frey, John E.; Aiello, Theresa; Beaman, Douglas N.; Combs, Scott D.; Fu, Shi-lin; Puckett, Jeffrey J.; Journal of Organic Chemistry; vol. 59; nb. 7; (1994); p. 1817 - 1830, View in Reaxys 4 of 9

Description (Association Stability constant of the complex with ... (MCS)) Solvent (Association (MCS))

CCl4

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Partner (Association (MCS))

chloranil

Yan, Bao-Zhen; Zhang, Zhao-Guo; Yuan, Han-Cheng; Wang, Long-Cheng; Xu, Jian-Hua; Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999); nb. 12; (1994); p. 2545 - 2550, View in Reaxys 5 of 9

Description (Association UV/VIS spectrum of the complex (MCS)) Solvent (Association (MCS))

CCl4

Partner (Association (MCS))

chloranil

Description (Association NMR spectrum of the complex (MCS)) Solvent (Association (MCS))

CD3CN

Partner (Association (MCS))

chloranil

Description (Association NMR spectrum of the complex (MCS)) Solvent (Association (MCS))

benzene-d6

Partner (Association (MCS))

chloranil

Description (Association IR spectrum of the complex (MCS)) Solvent (Association (MCS))

CCl4

Partner (Association (MCS))

phenol

Nifant'ev, E. E.; Ashkinadze, L. D.; Voropai, L. M.; Ruchkina, N. G.; Epshtein, L. M.; Milliaresi, E. E.; J. Gen. Chem. USSR (Engl. Transl.); vol. 55; nb. 1; (1985); p. 58 - 65,48 - 54, View in Reaxys 9 of 9

Description (Association Enthalpy of association (MCS)) Solvent (Association (MCS))

CCl4

Partner (Association (MCS))

phenol

Crystal Property Description (3)

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Colour & Other Properties

Location

colourless

yellow

References Barker, Graeme; Webster, Stacey; Johnson, David G.; Curley, Rachel; Andrews, Matthew; Young, Paul C.; MacGregor, Stuart A.; Lee, Ai-Lan; Journal of Organic Chemistry; vol. 80; nb. 20; (2015); p. 9807 - 9816, View in Reaxys

Page/Page column 114

light-yellow

Patent; GRUeNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; SCHIENE, Klaus; DE VRY, Jean; DAMANN, Nils; FRORMANN, Sven; LESCH, Bernhard; LEE, Jeewoo; KIM, Yong-Soo; KIM, Myeong-Seop; WO2010/127855; (2010); (A1) English, View in Reaxys Cabiddu, Maria Grazia; Cadoni, Enzo; De Montis, Stefania; Fattuoni, Claudia; Melis, Stefana; Usai, Michele; Tetrahedron; vol. 59; nb. 24; (2003); p. 4383 - 4387, View in Reaxys

Electrical Moment (4) 1 of 4

Description (Electrical Moment)

Dipole moment

Moment (Electrical Moment) [D]

0.71

Temperature (Electrical Moment) [°C]

Method (Electrical Moment)

Dielectric constant (ε)

Solvent (Electrical Moment)

benzene

Romm, I. P.; Gur'yanova, E. N.; Gineitite, V. L.; Ganyushin, L. A.; Udrenaite, E. B.; J. Gen. Chem. USSR (Engl. Transl.); vol. 53; nb. 10; (1983); p. 2323 - 2332,2094 - 2101, View in Reaxys 2 of 4

Description (Electrical Moment)

Dipole moment

Comment (Electrical Moment)

0.80 D

El'tsov; Zhurnal Organicheskoi Khimii; vol. 1; (1965); p. 1112,1121, View in Reaxys 3 of 4

Description (Electrical Moment)

Dipole moment

Moment (Electrical Moment) [D]

0.8

Method (Electrical Moment)

Dielectric constant (ε)

Solvent (Electrical Moment)

benzene

Springall et al.; Journal of the Chemical Society; (1949); p. 1524,1531, View in Reaxys 4 of 4

Description (Electrical Moment)

Dipole moment

Moment (Electrical Moment) [D]

Method (Electrical Moment)

Dielectric constant (ε)

Boeeseken; Henriquez; van der Spek; Recueil des Travaux Chimiques des Pays-Bas; vol. 55; (1936); p. 147, View in Reaxys Electrochemical Characteristics (5) 1 of 5

Description (Electrochemical Characteristics)

redox potential

Solvent (Electrochemical Characteristics)

various solvent(s)

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Comment (Electrochem- 1.13 V; Product: /BRN= 1373355/. No. of transm. electrons: 1. Method: cyclovoltammetry. ical Characteristics) Description: Pt button electrode (2 mm2 surface area), Ag/AgCl reference electrode, 0.15 mol/l Bu4NPF6, sweep rate 100 mV/s Product

1,3-Benzodioxolradikalkation

Eberson, Lennart; Hartshorn, Michael P.; McCullough, John J.; Persson, Ola; Radner, Finn; Acta Chemica Scandinavica; vol. 52; nb. 8; (1998); p. 1024 - 1028, View in Reaxys 2 of 5

Description (Electrochemical Characteristics)

redox potential

Solvent (Electrochemical Characteristics)

CH2Cl2

Comment (Electrochem- 1.07 V; Product: /BRN= 1373355/. No. of transm. electrons: 1. Method: cyclovoltammetry. ical Characteristics) Description: Pt button electrode (2 mm2 surface area), Ag/AgCl reference electrode, 0.15 mol/l Bu4NPF6 Product

1,3-Benzodioxolradikalkation

Eberson, Lennart; Hartshorn, Michael P.; McCullough, John J.; Persson, Ola; Radner, Finn; Acta Chemica Scandinavica; vol. 52; nb. 8; (1998); p. 1024 - 1028, View in Reaxys 3 of 5

Description (Electrochemical Characteristics)

oxidation potential

Solvent (Electrochemical Characteristics)

acetonitrile; various solvent(s)

Temperature (Electrochemical Characteristics) [°C]

Rudenko; Pragst; Russian Journal of Organic Chemistry; vol. 34; nb. 11; (1998); p. 1589 - 1626, View in Reaxys 4 of 5

Description (Electrochemical Characteristics)

oxidation potential

Solvent (Electrochemical Characteristics)

acetic acid; fluorosulfonic acid

Temperature (Electrochemical Characteristics) [°C]

-76

Rudenko; Pragst; Russian Journal of Organic Chemistry; vol. 34; nb. 11; (1998); p. 1589 - 1626, View in Reaxys 5 of 5

Description (Electrochemical Characteristics)

redox potential

Solvent (Electrochemical Characteristics)

acetonitrile

Comment (Electrochem- 1.45 V; Product: /BRN= 1373355/. Method: cyclovoltammetry. Description: Pt electrode vs. ical Characteristics) SCE, 0.1M Bu4NClO4 Product

1,3-Benzodioxolradikalkation

References

-3.43024E+06

Cass et al.; Journal of the Chemical Society; (1958); p. 2595, View in Reaxys

Standard.

Enthalpy of Vaporization (1) Enthalpy of VaReferences porization [Jmol-1]

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41449.3

Cass et al.; Journal of the Chemical Society; (1958); p. 2595, View in Reaxys

Interatomic Distances and Angles (1) Description References Electron distribution

Zweig et al.; Journal of the American Chemical Society; vol. 85; (1963); p. 3933, View in Reaxys

Ionization Potential (1) References Anderson III; Kollman; Domelsmith; Houk; ; vol. 101; nb. 9; (1979); p. 2344 - 2352, View in Reaxys Molecular Deformation (2) Description (MoComment (Molec- References lecular Deforma- ular Deformation) tion) Rotational constants Rotational constants Optics (1) Description (Optics) Linear dichroism

Pietraperzia; Zoppi; Becucci; Droghetti; Castellucci; Chemical Physics Letters; vol. 385; nb. 3-4; (2004); p. 304 - 308, View in Reaxys ground state. Object(s) of Study: excited state

Kisiel, Zbigniew; Pszczolkowski, Lech; Pietraperzia; Becucci; Caminati; Meyer, Rolf; Physical Chemistry Chemical Physics; vol. 6; nb. 24; (2004); p. 5469 - 5475, View in Reaxys

References Spanget-Larsen, Jens; Uschmann, Joachim; Gleiter, Rolf; Journal of Physical Chemistry; vol. 94; (1990); p. 2334 - 2344, View in Reaxys

NMR Spectroscopy (15) 1 of 15

Description (NMR Spec- Spectrum troscopy) Nucleus (NMR Spectroscopy)

Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]

500

Location

supporting information

Liu, Chun; Oblak, E. Zachary; Vander Wal, Mark N.; Dilger, Andrew K.; Almstead, Danielle K.; MacMillan, David W.C.; Journal of the American Chemical Society; vol. 138; nb. 7; (2016); p. 2134 - 2137, View in Reaxys 2 of 15

Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)

Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]

300

Location

supporting information

Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)

13C

Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]

75.5

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Location

supporting information

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

17O

Solvents (NMR Spectro- toluene-d8 scopy) Temperature (NMR Spectroscopy) [°C]

Biekofsky, Rodolfo R.; Pomilio, Alicia B.; Contreras, Ruben H.; Orendt, Anita M.; Facelli, Julio C.; Journal of Physical Chemistry; vol. 94; nb. 19; (1990); p. 7418 - 7423, View in Reaxys 5 of 15

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

Solvents (NMR Spectro- CD3NO2 scopy) Ansink, Harold; Cerfontain, Hans; Recueil des Travaux Chimiques des Pays-Bas; vol. 108; nb. 11; (1989); p. 395 403, View in Reaxys 6 of 15

Description (NMR Spec- Spin-spin coupling constants troscopy) Solvents (NMR Spectro- CD3NO2 scopy) Comment (NMR Spectroscopy)

1H-1H.

Ansink, Harold; Cerfontain, Hans; Recueil des Travaux Chimiques des Pays-Bas; vol. 108; nb. 11; (1989); p. 395 403, View in Reaxys 7 of 15

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

Solvents (NMR Spectro- CDCl3 scopy) Castillo, P.; Rodriguez-Ubis, J. C.; Rodriguez, F.; Synthesis; nb. 10; (1986); p. 839 - 840, View in Reaxys 9 of 15

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

13C

Solvents (NMR Spectro- CDCl3 scopy) Temperature (NMR Spectroscopy) [°C]

Hanson, A. W.; McCulloch, A. W.; McInnes, A. G.; Canadian Journal of Chemistry; vol. 64; (1986); p. 1450 - 1457, View in Reaxys

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10 of 15

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

13C

Solvents (NMR Spectro- CDCl3 scopy) Temperature (NMR Spectroscopy) [°C]

Barr, Neal; Dyke, Stanley F.; Frost, R. L. W.; Organic Magnetic Resonance; vol. 22; nb. 5; (1984); p. 277 - 279, View in Reaxys 11 of 15

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

13C

Solvents (NMR Spectro- CDCl3 scopy) Smolinski, Stefan; Balazy, Michal; Iwamura, Hiizu; Sugawara, Tadashi; Kawada, Yuzo; Iwamura, Michiko; Bulletin of the Chemical Society of Japan; vol. 55; nb. 4; (1982); p. 1106 - 1111, View in Reaxys 12 of 15

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

13C

Solvents (NMR Spectro- dimethylsulfoxide-d6 scopy) Katritzky, Alan R.; Ellison, Joan; Frank, Judit; Rakoczy, Piroska; Radics, Lajos; Gacs-Baitz, Eszter; Organic Magnetic Resonance; vol. 16; nb. 4; (1981); p. 280 - 284, View in Reaxys 13 of 15

Description (NMR Spec- NMR with shift reagents troscopy) Platzer et al.; Bulletin de la Societe Chimique de France; (1975); p. 227, View in Reaxys

14 of 15

Description (NMR Spec- NMR troscopy) Schaefer et al.; Canadian Journal of Chemistry; vol. 53; (1975); p. 2734, View in Reaxys; Sasaki et al.; Chemical and Pharmaceutical Bulletin; vol. 15; (1967); p. 599,601, View in Reaxys

15 of 15

Description (NMR Spec- Spectrum troscopy) Comment (NMR Spectroscopy)

Santavy et al.; Acta Univ. Palack. Olomuc Suppl. XIII; p. 83 - 122, View in Reaxys IR Spectroscopy (12) 1 of 12

Description (IR Spectroscopy)

Bands

Santavy et al.; Acta Univ. Palack. Olomuc Suppl. XIII; p. 83 - 122, View in Reaxys; Barker, Graeme; Webster, Stacey; Johnson, David G.; Curley, Rachel; Andrews, Matthew; Young, Paul C.; MacGregor, Stuart A.; Lee, AiLan; Journal of Organic Chemistry; vol. 80; nb. 20; (2015); p. 9807 - 9816, View in Reaxys 2 of 12

Description (IR Spectroscopy)

Spectrum

Solvent (IR Spectroscopy)

neat liquid

Jeon, Sangmi; Choo, Jaebum; Kim, Sungwhan; Kwon, Younghi; Kim, Jin-Yeol; Lee, Young-Il; Chung, Hoeil; Journal of Molecular Structure; vol. 609; nb. 1-3; (2002); p. 159 - 167, View in Reaxys 3 of 12

Description (IR Spectroscopy)

Spectrum

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Solvent (IR Spectroscopy)

gas

Jeon, Sangmi; Choo, Jaebum; Kim, Sungwhan; Kwon, Younghi; Kim, Jin-Yeol; Lee, Young-Il; Chung, Hoeil; Journal of Molecular Structure; vol. 609; nb. 1-3; (2002); p. 159 - 167, View in Reaxys 4 of 12

Description (IR Spectroscopy)

Bands

Solvent (IR Spectroscopy)

gas

Jeon, Sangmi; Choo, Jaebum; Kim, Sungwhan; Kwon, Younghi; Kim, Jin-Yeol; Lee, Young-Il; Chung, Hoeil; Journal of Molecular Structure; vol. 609; nb. 1-3; (2002); p. 159 - 167, View in Reaxys 5 of 12

Description (IR Spectroscopy)

Bands

Solvent (IR Spectroscopy)

neat liquid

Jeon, Sangmi; Choo, Jaebum; Kim, Sungwhan; Kwon, Younghi; Kim, Jin-Yeol; Lee, Young-Il; Chung, Hoeil; Journal of Molecular Structure; vol. 609; nb. 1-3; (2002); p. 159 - 167, View in Reaxys 6 of 12

Description (IR Spectroscopy)

Far IR spectrum

Comment (IR Spectroscopy)

ground state

Laane, Jaan; Journal of Physical Chemistry A; vol. 104; nb. 33; (2000); p. 7715 - 7733, View in Reaxys 7 of 12

Description (IR Spectroscopy)

Spectrum

Solvent (IR Spectroscopy)

gas

Comment (IR Spectroscopy)

270 - 55 1/cm

Sakurai; Meinander; Morris; Laane; Journal of the American Chemical Society; vol. 121; nb. 21; (1999); p. 5056 5062, View in Reaxys 8 of 12

Description (IR Spectroscopy)

Bands

Solvent (IR Spectroscopy)

gas

Comment (IR Spectroscopy)

327.5 - 58.2 1/cm

Sakurai; Meinander; Morris; Laane; Journal of the American Chemical Society; vol. 121; nb. 21; (1999); p. 5056 5062, View in Reaxys 9 of 12

Description (IR Spectroscopy)

Bands

Solvent (IR Spectroscopy)

gaseous matrix

Comment (IR Spectroscopy)

158 - 413 cm**(-1)

Smithson, T. L.; Duckett, J. A.; Wieser, H.; Journal of Physical Chemistry; vol. 88; nb. 6; (1984); p. 1102 - 1109, View in Reaxys 10 of 12

Description (IR Spectroscopy)

Normant; Feugeas; Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences; vol. 258; (1964); p. 2846, View in Reaxys 11 of 12

Description (IR Spectroscopy)

Spectrum

Solvent (IR Spectroscopy)

neat (no solvent)

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Comment (IR Spectroscopy)

4000 - 667 cm**(-1)

Briggs et al.; Analytical Chemistry; vol. 29; (1957); p. 904,905, View in Reaxys 12 of 12

Description (IR Spectroscopy)

Spectrum

Solvent (IR Spectroscopy)

CCl4

Comment (IR Spectroscopy)

5000 - 833 cm**(-1)

Gensler; Samour; Journal of Organic Chemistry; vol. 18; (1953); p. 9,13, View in Reaxys Mass Spectrometry (2) Description (Mass References Spectrometry) electron impact (EI); spectrum

Pinalli, Roberta; Barboza, Tahnee; Bianchi, Federica; Massera, Chiara; Ugozzoli, Franco; Dalcanale, Enrico; Supramolecular Chemistry; vol. 25; nb. 9-11; (2013); p. 682 - 687, View in Reaxys

resonance enhanced multiphoton ionization (REMPI)

He, Yonggang; Wu, Chengyin; Kong, Wei; Chemical Physics Letters; vol. 402; nb. 1-3; (2005); p. 212 216, View in Reaxys

UV/VIS Spectroscopy (13) 1 of 13

Description (UV/VIS Spectroscopy)

Spectrum

Solvent (UV/VIS Spectroscopy)

acetonitrile

Absorption Maxima (UV/ 231.5; 281 VIS) [nm] Ext./Abs. Coefficient [l·mol-1cm-1]

2950; 3130

Yang, Jinliang; Xu, Fei; Shi, Suqing; Nie, Jun; Photochemical and Photobiological Sciences; vol. 11; nb. 8; (2012); p. 1377 - 1382, View in Reaxys 2 of 13

Description (UV/VIS Spectroscopy)

Spectrum

Comment (UV/VIS Spectroscopy)

excited singlet state

Laane, Jaan; Journal of Physical Chemistry A; vol. 104; nb. 33; (2000); p. 7715 - 7733, View in Reaxys 3 of 13

Description (UV/VIS Spectroscopy)

Spectrum

Solvent (UV/VIS Spectroscopy)

gas

Comment (UV/VIS Spectroscopy)

low pressure. Object(s) of Study: vibrational analysis

Laane; Bondoc; Sakurai; Morris; Meinander; Choo; Journal of the American Chemical Society; vol. 122; nb. 11; (2000); p. 2628 - 2634, View in Reaxys 4 of 13

Description (UV/VIS Spectroscopy)

Spectrum

Comment (UV/VIS Spectroscopy)

34800 - 35200 1/cm

Laane; Sakurai; Klots; Meinander; Morris; Chiang; Bondoc; Journal of Molecular Structure; vol. 480-481; (1999); p. 189 - 196, View in Reaxys 5 of 13

Description (UV/VIS Spectroscopy)

Absorption maxima

Solvent (UV/VIS Spectroscopy)

cyclohexane

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Absorption Maxima (UV/ 283.29; 230.95; 196.85 VIS) [nm] Ext./Abs. Coefficient [l·mol-1cm-1]

3162; 3162; 39811

Spanget-Larsen, Jens; Uschmann, Joachim; Gleiter, Rolf; Journal of Physical Chemistry; vol. 94; (1990); p. 2334 - 2344, View in Reaxys 6 of 13

Description (UV/VIS Spectroscopy)

Spectrum

Solvent (UV/VIS Spectroscopy)

hexane

Comment (UV/VIS Spectroscopy)

200 - 300 nm

Smolinski, Stefan; Balazy, Michal; Iwamura, Hiizu; Sugawara, Tadashi; Kawada, Yuzo; Iwamura, Michiko; Bulletin of the Chemical Society of Japan; vol. 55; nb. 4; (1982); p. 1106 - 1111, View in Reaxys 7 of 13

Description (UV/VIS Spectroscopy)

Absorption maxima

Solvent (UV/VIS Spectroscopy)

hexane

Absorption Maxima (UV/ 233; 285 VIS) [nm] Ext./Abs. Coefficient [l·mol-1cm-1]

2951; 3090

Description (UV/VIS Spectroscopy)

UV/VIS

Alves et al.; Journal of Molecular Spectroscopy; vol. 77; (1979); p. 124, View in Reaxys; Baddeley et al.; Journal of the Chemical Society; (1961); p. 2516,2517, View in Reaxys; Walterova et al.; Collection of Czechoslovak Chemical Communications; vol. 39; (1974); p. 2449,2451, View in Reaxys 9 of 13

Description (UV/VIS Spectroscopy)

Absorption maxima

Archer,A.W. et al.; Journal of the Chemical Society [Section] B: Physical Organic; (1971); p. 1231 - 1240, View in Reaxys; El'tsov; Zhurnal Organicheskoi Khimii; vol. 1; (1965); p. 1112,1121, View in Reaxys; Santavy et al.; Acta Univ. Palack. Olomuc Suppl. XIII; p. 15 - 18, View in Reaxys 10 of 13

Description (UV/VIS Spectroscopy)

Spectrum

Solvent (UV/VIS Spectroscopy)

ethanol

Comment (UV/VIS Spectroscopy)

230 - 295 nm

Garofano; Oliverio; Annali di Chimica (Rome, Italy); vol. 47; (1957); p. 896,904, View in Reaxys; Gensler; Samour; Journal of Organic Chemistry; vol. 18; (1953); p. 9,13, View in Reaxys 11 of 13

Description (UV/VIS Spectroscopy)

Spectrum

Solvent (UV/VIS Spectroscopy)

hexane

Comment (UV/VIS Spectroscopy)

225 - 330 nm

Hillmer; Schorning; Zeitschrift fuer Physikalische Chemie (Leipzig); vol. <A> 167; (1934); p. 407,414, 415; Zeitschrift fuer Physikalische Chemie (Leipzig); vol. <A> 168; (1934); p. 81,101, 102, View in Reaxys 12 of 13

Description (UV/VIS Spectroscopy)

Absorption maxima

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Solvent (UV/VIS Spectroscopy)

hexane

Absorption Maxima (UV/ 278; 284; 290 VIS) [nm] Hillmer; Schorning; Zeitschrift fuer Physikalische Chemie (Leipzig); vol. <A> 167; (1934); p. 407,414, 415; Zeitschrift fuer Physikalische Chemie (Leipzig); vol. <A> 168; (1934); p. 81,101, 102, View in Reaxys 13 of 13

Description (UV/VIS Spectroscopy)

Spectrum

Santavy et al.; Acta Univ. Palack. Olomuc Suppl. XIII; p. 15 - 18, View in Reaxys Rotational Spectroscopy (2) Description (Rota- Comment (Rota- References tional Spectrosco- tional Spectroscopy) py) Rotational spectrum

ambient temperature. Object(s) of Study: vapour

Kisiel, Zbigniew; Pszczolkowski, Lech; Pietraperzia; Becucci; Caminati; Meyer, Rolf; Physical Chemistry Chemical Physics; vol. 6; nb. 24; (2004); p. 5469 - 5475, View in Reaxys

Microwave spectrum

Laane; Sakurai; Klots; Meinander; Morris; Chiang; Bondoc; Journal of Molecular Structure; vol. 480-481; (1999); p. 189 - 196, View in Reaxys

Raman Spectroscopy (5) Description (Ram- Solvent (Raman an Spectroscopy) Spectroscopy)

Comment (Raman Spectroscopy)

References

vapour

Laane, Jaan; Haller, Kristjan; Sakurai, Sachie; Morris, Kevin; Autrey, Daniel; Arp, Zane; Chiang, Whe-Yi; Combs, Amanda; Journal of Molecular Structure; vol. 650; nb. 1-3; (2003); p. 57 - 68, View in Reaxys

Low frequency Raman spectrum

Spectrum

neat liquid

Jeon, Sangmi; Choo, Jaebum; Kim, Sungwhan; Kwon, Younghi; Kim, Jin-Yeol; Lee, Young-Il; Chung, Hoeil; Journal of Molecular Structure; vol. 609; nb. 1-3; (2002); p. 159 - 167, View in Reaxys

Bands

neat liquid

Jeon, Sangmi; Choo, Jaebum; Kim, Sungwhan; Kwon, Younghi; Kim, Jin-Yeol; Lee, Young-Il; Chung, Hoeil; Journal of Molecular Structure; vol. 609; nb. 1-3; (2002); p. 159 - 167, View in Reaxys

Spectrum

gas

Sakurai; Meinander; Morris; Laane; Journal of the American Chemical Society; vol. 121; nb. 21; (1999); p. 5056 - 5062, View in Reaxys

Bands

gas

Sakurai; Meinander; Morris; Laane; Journal of the American Chemical Society; vol. 121; nb. 21; (1999); p. 5056 - 5062, View in Reaxys

Fluorescence Spectroscopy (6) Description (Fluo- Solvent (Fluoresrescence Speccence Spectrotroscopy) scopy)

Temperature (Flu- Comment (Fluoorescence Spec- rescence Spectroscopy) [°C] troscopy)

Fluorescence excitation spectrum Spectrum

References

Pietraperzia; Zoppi; Becucci; Droghetti; Castellucci; Chemical Physics Letters; vol. 385; nb. 3-4; (2004); p. 304 - 308, View in Reaxys gaseous matrix

pressure dependence. Object(s) of Study: rotational analysis. Object(s) of Study: vibrational analysis

Kisiel, Zbigniew; Pszczolkowski, Lech; Pietraperzia; Becucci; Caminati; Meyer, Rolf; Physical Chemistry Chemical Physics; vol. 6; nb. 24; (2004); p. 5469 - 5475, View in Reaxys

Spectrum

excited singlet state

Laane, Jaan; Journal of Physical Chemistry A; vol. 104; nb. 33; (2000); p. 7715 - 7733, View in Reaxys

Fluorescence excitation spectrum

low pressure. Object(s) of Study: vibrational analysis

Laane; Bondoc; Sakurai; Morris; Meinander; Choo; Journal of the American Chemical Society; vol. 122; nb. 11; (2000); p. 2628 - 2634, View in Reaxys

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2016-08-05 15:49:11

Spectrum

neat (no solvent)

34800 - 35200 1/cm

Laane; Sakurai; Klots; Meinander; Morris; Chiang; Bondoc; Journal of Molecular Structure; vol. 480-481; (1999); p. 189 - 196, View in Reaxys

10 - 1100 1/cm

Sakurai; Meinander; Morris; Laane; Journal of the American Chemical Society; vol. 121; nb. 21; (1999); p. 5056 - 5062, View in Reaxys

Other Spectroscopic Methods (1) Description (Oth- References er Spectroscopic Methods) Photoelectron spectrum

Anderson III; Kollman; Domelsmith; Houk; ; vol. 101; nb. 9; (1979); p. 2344 - 2352, View in Reaxys; He, Yonggang; Wu, Chengyin; Kong, Wei; Chemical Physics Letters; vol. 402; nb. 1-3; (2005); p. 212 - 216, View in Reaxys

Pharmacological Data (35) 1 of 35

Comment (Pharmacological Data)

Bioactivities present

Patent; Endura S.p.A.; US6342613; (2002); (B1) English, View in Reaxys; Patent; ELI LILLY AND COMPANY; EP254577; (1988); (A1) English, View in Reaxys; Fentrill,G.I.; Mirrington,R.N.; Australian Journal of Chemistry; vol. 25; (1972); p. 1731 - 1735, View in Reaxys; Patent; YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.; EP873990; (1998); (A1) English, View in Reaxys; Patent; Eli Lilly and Company; US4082774; (1978); (A1) English, View in Reaxys; Patent; Hoffmann-La Roche Inc.; US4143227; (1979); (A1) English, View in Reaxys; Patent; Mitsui Toatsu Chemicals, Inc.; US4157333; (1979); (A1) English, View in Reaxys; Patent; Brichima S.p.A.; US4183861; (1980); (A1) English, View in Reaxys; Patent; Haarmann and Reimer GmbH; US4190583; (1980); (A1) English, View in Reaxys; Patent; Hoffmann-La Roche Inc.; US4435406; (1984); (A1) English, View in Reaxys; Patent; G. D. Searle and Co.; US6172101; (2001); (B2) English, View in Reaxys; Patent; Warner-Lambert Company; US6177423; (2001); (B1) English, View in Reaxys; Bach,N.J. et al.; Journal of Medicinal Chemistry; vol. 20; nb. 8; (1977); p. 1105 - 1107, View in Reaxys; Dyke,S.F.; Tiley,E.P.; Tetrahedron; vol. 31; (1975); p. 561 - 568, View in Reaxys; Patent; G.D. Searle and Co.; US5705500; (1998); (A1) English, View in Reaxys; Patent; G. D. Searle and Co.; US5753660; (1998); (A1) English, View in Reaxys; Patent; G.D. Searle and Co.; US5756533; (1998); (A1) English, View in Reaxys; Patent; FMC Corporation; US4895871; (1990); (A1) English, View in Reaxys; Patent; SmithKline Beecham Corporation; US6262113; (2001); (B1) English, View in Reaxys; Patent; WarnerLambert Company; US5482960; (1996); (A1) English, View in Reaxys 2 of 35

Comment (Pharmacological Data)

Bioactivities present

Patent; G.D. Searle and Co.; US6046190; (2000); (A1) English, View in Reaxys; Patent; G.D. Searle and Co.; US6100277; (2000); (A1) English, View in Reaxys; Patent; G. D. Searle and Co.; US6143747; (2000); (A1) English, View in Reaxys; Patent; G. D. Dearle and Co.; US6150556; (2000); (A1) English, View in Reaxys; Patent; Yoshitomi Pharmaceutical Industries, Ltd.; US5864039; (1999); (A1) English, View in Reaxys; Patent; SmithKline Beecham Corporation; US5886044; (1999); (A1) English, View in Reaxys; Patent; G. D. Searle and Company; US5968970; (1999); (A1) English, View in Reaxys; Patent; G.D. Searle and Co.; US5985870; (1999); (A1) English, View in Reaxys; Patent; Eli Lilly and Company; US5116874; (1992); (A1) English, View in Reaxys; Patent; Sumitomo Chemical Company, Limited; US5235068; (1993); (A1) English, View in Reaxys; Patent; Commonwealth Scientific and Industrial Research Organization; US6448433; (2002); (B1) English, View in Reaxys; Patent; Ube Industries, Ltd.; US6603024; (2003); (B1) English, View in Reaxys; Patent; G.D. SEARLE and CO.; EP970066; (2003); (B1) English, View in Reaxys; Patent; G. D. Searle and Co.; US6388132; (2002); (B1) English, View in Reaxys; Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/4732; (2004); (A1) English, View in Reaxys; Cabiddu,S. et al.; Gazzetta Chimica Italiana; vol. 98; (1968); p. 800 - 809, View in Reaxys; Patent; BORREGAARD ITALIA S.P.A.; WO2004/14827; (2004); (A1) English, View in Reaxys; Archer,A.W. et al.; Journal of the Chemical Society [Section] B: Physical Organic; (1971); p. 1231 - 1240, View in Reaxys; Yagupol'skii,L.M. et al.; J. Gen. Chem. USSR (Engl. Transl.); vol. 34; nb. 1; (1964); p. 307 - 317,304 - 312, View in Reaxys; Cabiddu,S. et al.; Journal of Organometallic Chemistry; vol. 136; (1977); p. 139 - 146, View in Reaxys 3 of 35

Comment (Pharmacological Data)

Bioactivities present

Patent; Eli Lilly and Company, Eli Lilly and Company; WO2004/48329; (2004); (A1) English, View in Reaxys; Patent; Amiri, Payman; Fantl, Wendy; Levine, Barry Haskell; Poon, Daniel J.; Ramurthy, Savithri; Renhowe, Paul A.; Subramanian, Sharadha; Sung, Leonard; US2004/122237; (2004); (A1) English, View in Reaxys; Patent; MITENI S.p.A.; EP1502908; (2005); (A1) English, View in Reaxys; Patent; ENDURA S.P.A.; WO2005/42512; (2005); (A1) English, View in Reaxys; Patent; Ube Industries, Ltd.; EP1574509; (2005); (A1) English, View in Reaxys; Patent; REDDY US THERAPEUTICS, INC.; KALLEDA, Srinivas; PADAKANTI, Srinivas; KUMAR SWAMY, Nalivela; YELESWARAPU, Koteswar, Rao; ALEXANDER, Christopher, W.; KHANNA, Ish, Kumar; IQBAL, Javed; PILLARISETTI, Sivaram; PAL, Manojit; BARANGE, Deepak; WO2006/34473; (2006); (A2) English, View in Reaxys; Patent; Pfizer Inc.; US6017945; (2000); (A1) English, View in Reaxys; Patent; UBE INDUSTRIES, LTD.; WO2007/20964; (2007); (A1) Japanese, View in Reaxys; Patent; SMITHKLINE BEECHAM COR-

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2016-08-05 15:49:11

PORATION; WO2007/127505; (2007); (A2) English, View in Reaxys; Patent; RHODIA CHIMIE; US2008/21228; (2008); (A1) English, View in Reaxys; Perkin; Robinson; Thomas; Journal of the Chemical Society; vol. 95; (1909); p. 1979, View in Reaxys; Mameli; Boi; Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti; vol. <5> 15 II; (1906); p. 104; Gazzetta Chimica Italiana; vol. 36 II; (1906); p. 380, View in Reaxys; Moureu; Bulletin de la Societe Chimique de France; vol. <3> 15; (1896); p. 655; Annales de Chimie (Cachan, France); vol. <7> 18; (1899); p. 104, View in Reaxys; Barger; Journal of the Chemical Society; vol. 93; (1908); p. 565; Chemische Berichte; vol. 42; (1909); p. 763, View in Reaxys; Jones; Robinson; Journal of the Chemical Society; vol. 111; (1917); p. 913, View in Reaxys; Orr; Robinson; Williams; Journal of the Chemical Society; vol. 111; (1917); p. 948, View in Reaxys; Ghosh; Journal of the Chemical Society; vol. 107; (1915); p. 1595, View in Reaxys; Spaeth; Quietensky; Chemische Berichte; vol. 60; (1927); p. 1890, View in Reaxys; Mosettig; Jovanovic; Monatshefte fuer Chemie; vol. 53/54; (1929); p. 435, View in Reaxys; Baker; Field; Journal of the Chemical Society; (1932); p. 86,87, View in Reaxys 4 of 35

Comment (Pharmacological Data)

Bioactivities present

Johnson et al.; Journal of the Chemical Society; (1953); p. 2136,2138, View in Reaxys; Haworth; Kelly; Journal of the Chemical Society; (1936); p. 745, View in Reaxys; Garofano; Oliverio; Annali di Chimica (Rome, Italy); vol. 47; (1957); p. 896,904, View in Reaxys; Gensler; Stouffer; Journal of Organic Chemistry; vol. 23; (1958); p. 908, View in Reaxys; Birch; Journal of the Chemical Society; (1947); p. 102,104, View in Reaxys; Helfer; Mottier; Chim. et Ind. Sonderband 14. Congr. Chim. ind. Paris 1934, Bd. 1, Tl. 9, S. 1, 3, View in Reaxys; Mottier; Arch. Sci. phys. nat.; vol. 17; (1935); p. 289, View in Reaxys; Laskina; Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation); vol. 32; (1959); p. 878,880; engl. Ausg. S. 895, 897, View in Reaxys; Cass et al.; Journal of the Chemical Society; (1958); p. 2595, View in Reaxys; Gensler; Samour; Journal of Organic Chemistry; vol. 18; (1953); p. 9,13, View in Reaxys; Springall et al.; Journal of the Chemical Society; (1949); p. 1524,1531, View in Reaxys; Schorygin et al.; Zhurnal Obshchei Khimii; vol. 8; (1938); p. 975,978; Chem. Zentralbl.; vol. 110; nb. I; (1939); p. 2178, View in Reaxys; Briggs et al.; Analytical Chemistry; vol. 29; (1957); p. 904,905, View in Reaxys; Drabek; Chemicke Zvesti; vol. 10; (1956); p. 357,364; Chem.Abstr.; (1956); p. 16023, View in Reaxys; Campbell et al.; Journal of Organic Chemistry; vol. 16; (1951); p. 1736,1740, View in Reaxys; Eliseewa; Debizkaja; Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation); vol. 29; (1956); p. 1894; engl. Ausg. S. 2043, View in Reaxys; Baker; Journal of the Chemical Society; (1931); p. 1765,1768, View in Reaxys; Ruschtschinskii; Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation); vol. 7; (1934); p. 1113; Chem. Zentralbl.; vol. 107; nb. II; (1936); p. 2901, View in Reaxys; Spaeth et al.; Chemische Berichte; vol. 66; (1933); p. 125,129, View in Reaxys; Schwenk; Papa; Journal of Organic Chemistry; vol. 10; (1945); p. 232,234, View in Reaxys 5 of 35

Comment (Pharmacological Data)

Bioactivities present

Holter; Bretschneider; Monatshefte fuer Chemie; vol. 53/54; (1929); p. 978, View in Reaxys; Sonn; Benirschke; Chemische Berichte; vol. 54; (1921); p. 1732, View in Reaxys; Boeeseken; Henriquez; van der Spek; Recueil des Travaux Chimiques des Pays-Bas; vol. 55; (1936); p. 147, View in Reaxys; Brown; Wilzbach; Urry; Canadian Journal of Research, Section B: Chemical Sciences; vol. 27; (1949); p. 398,403, View in Reaxys; Hillmer; Schorning; Zeitschrift fuer Physikalische Chemie (Leipzig); vol. <A> 167; (1934); p. 407,414, 415; Zeitschrift fuer Physikalische Chemie (Leipzig); vol. <A> 168; (1934); p. 81,101, 102, View in Reaxys; Mathur et al.; Journal of the American Chemical Society; vol. 79; (1957); p. 3582,3585, View in Reaxys; Kindler; Archiv der Pharmazie (Weinheim, Germany); (1927); p. 390,400; Chem. Zentralbl.; vol. 95; nb. II; (1924); p. 1404, View in Reaxys; Keck,G.E.; Webb,R.R.; Journal of the American Chemical Society; vol. 103; (1981); p. 3173, View in Reaxys; Mann; Pragnall; Journal of the Chemical Society; (1965); p. 4120,4124, View in Reaxys; El'tsov; Zhurnal Organicheskoi Khimii; vol. 1; (1965); p. 1112,1121, View in Reaxys; Clark et al.; Tetrahedron Letters; (1976); p. 3361, View in Reaxys; Dyke; Tiley; Tetrahedron; vol. 31; (1975); p. 561,562, 566, View in Reaxys; Alves et al.; Journal of Molecular Spectroscopy; vol. 77; (1979); p. 124, View in Reaxys; Schaefer et al.; Canadian Journal of Chemistry; vol. 53; (1975); p. 2734, View in Reaxys; Baddeley et al.; Journal of the Chemical Society; (1961); p. 2516,2517, View in Reaxys; Zweig et al.; Journal of the American Chemical Society; vol. 85; (1963); p. 3933, View in Reaxys; Gensler et al.; Journal of the American Chemical Society; vol. 82; (1960); p. 1714,1724, View in Reaxys; Normant; Feugeas; Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences; vol. 258; (1964); p. 2846, View in Reaxys; Santavy et al.; Acta Univ. Palack. Olomuc Suppl. XIII; p. 83 - 122, View in Reaxys; Dallacker; Binsack; Monatshefte fuer Chemie; vol. 92; (1961); p. 492, View in Reaxys 6 of 35

Comment (Pharmacological Data)

Bioactivities present

Laskina; Dewizkaja; J. Appl. Chem. USSR (Engl. Transl.); vol. 34; (1961); p. 2338,2214; Chem.Abstr.; nb. 8611; (1962), View in Reaxys; Wilkinson et al.; Journal of Agricultural and Food Chemistry; vol. 14; (1966); p. 73,74, View in Reaxys; Platzer et al.; Bulletin de la Societe Chimique de France; (1975); p. 227, View in Reaxys; Walterova et al.; Collection of Czechoslovak Chemical Communications; vol. 39; (1974); p. 2449,2451, View in Reaxys; Mann; Pragnell; Chemistry and Industry (London, United Kingdom); (1964); p. 1386, View in Reaxys; Duckett et al.; Chemical Physics Letters; vol. 64; (1979); p. 261, View in Reaxys; Beltrame; Gelli; Gazzetta Chimica Italiana; vol. 106; (1976); p. 993,994,996, View in Reaxys; Sasaki et al.; Chemical and Pharmaceutical Bulletin; vol. 15; (1967); p. 599,601, View in Reaxys; Anderson III; Kollman; Domelsmith; Houk; ; vol. 101; nb. 9; (1979); p. 2344 2352, View in Reaxys; Spanget-Larsen, Jens; Uschmann, Joachim; Gleiter, Rolf; Journal of Physical Chemistry; vol. 94; (1990); p. 2334 - 2344, View in Reaxys; Daukshas; Gaidyalis; Brukshtus; Ramanauskas; Labanauskas; Gasperavichene; Yautakene; Lapinskas; Lauzhikene; Pharmaceutical Chemistry Journal; vol. 23; nb. 8; (1990);

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2016-08-05 15:49:11

p. 660 - 664, View in Reaxys; Daukshas, V. K.; Gaidyalis, P. G.; Udrenaite, E. B.; Labanauskas, L. K.; Gasperavichene, G. A.; et al.; Pharmaceutical Chemistry Journal; vol. 23; nb. 12; (1989); p. 990 - 995; Khimiko-Farmatsevticheskii Zhurnal; vol. 23; nb. 12; (1989); p. 1466 - 1470, View in Reaxys; Biekofsky, Rodolfo R.; Pomilio, Alicia B.; Contreras, Ruben H.; Orendt, Anita M.; Facelli, Julio C.; Journal of Physical Chemistry; vol. 94; nb. 19; (1990); p. 7418 - 7423, View in Reaxys; Azafonov, N. E.; Sedishev, I. P.; Zhulin, V. M.; Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation); vol. 39; nb. 4.1; (1990); p. 738 - 741; Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya; nb. 4; (1990); p. 829 - 832, View in Reaxys; Chapuzet, Jean-Marc; Simonet, Jacques; Tetrahedron; vol. 47; nb. 4/5; (1991); p. 791 - 798, View in Reaxys; Stamos, Ioannis K.; Tetrahedron Letters; vol. 26; nb. 4; (1985); p. 477 - 480, View in Reaxys; Bhatt, M. Vivekananda; Babu, J. Ramesh; Tetrahedron Letters; vol. 25; nb. 32; (1984); p. 3497 - 3500, View in Reaxys; Crombie, Leslie; Horsham, Mark A.; Blade, Robert J.; Tetrahedron Letters; vol. 28; nb. 41; (1987); p. 4879 - 4882, View in Reaxys; Ishibashi, Hiroyuki; Nakatani, Hiroshi; Umei, Yoshizumi; Ikeda, Masazumi; Tetrahedron Letters; vol. 26; nb. 36; (1985); p. 4373 4374, View in Reaxys; Node, Manabu; Nishide, Kiyoharu; Fuji, Kaoru; Fujita, Eiichi; Journal of Organic Chemistry; vol. 45; nb. 22; (1980); p. 4275 - 4277, View in Reaxys 7 of 35

Comment (Pharmacological Data)

Bioactivities present

Hatjiarapoglou, Lazaros; Varvoglis, Anastassios; Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999); (1989); p. 379 - 382, View in Reaxys; Bonsignore, Leonardo; Fadda, Anna Maria; Loy, Giuseppe; Maccioni, Antonio; Podda, Gianni; Journal of Heterocyclic Chemistry; vol. 20; (1983); p. 703 - 707, View in Reaxys; Melis, Stefana; Piras, Pier Paolo; Plumitallo, Antonio; Sotgiu, Francesca; Journal of Heterocyclic Chemistry; vol. 20; (1983); p. 1413 - 1414, View in Reaxys; Ruffin, L. D.; Bowlus, S. B.; Journal of Heterocyclic Chemistry; vol. 20; (1983); p. 461 - 462, View in Reaxys; Melis, Stefana; Monni, Francesca; Piras, Pier Paolo; Sotgiu, Francesca; Journal of Heterocyclic Chemistry; vol. 20; (1983); p. 463, View in Reaxys; Sokolovskii, A.V.; Zelechonok, Yu.B.; Zorin, V.V.; Zlotskii, S.S.; Rakhmankulov, D.L.; Chemistry of Heterocyclic Compounds (New York, NY, United States); vol. 22; nb. 4; (1986); p. 467 - 468; Khimiya Geterotsiklicheskikh Soedinenii; vol. 22; nb. 4; (1986); p. 565 - 566, View in Reaxys; Castillo, P.; Rodriguez-Ubis, J. C.; Rodriguez, F.; Synthesis; nb. 10; (1986); p. 839 - 840, View in Reaxys; Bhatt, M. Vivekananda; El-Morey, Saad S.; Synthesis; nb. 12; (1982); p. 1048 - 1050, View in Reaxys; Thomas, H. G.; Schmitz, A.; Synthesis; nb. 1; (1985); p. 31 - 33, View in Reaxys; Chiles, Margaret Shea; Jackson, Donald D.; Reeves, Perry C.; Journal of Organic Chemistry; vol. 45; nb. 14; (1980); p. 2915 - 2918, View in Reaxys; Citterio, Attilio; Gentile, Anna; Minisci, Francesco; Navarrini, Valter; Serravalle, Marco; Ventura, Susanna; Journal of Organic Chemistry; vol. 49; nb. 23; (1984); p. 4479 - 4482, View in Reaxys; Tomar, S. S.; Walia, Suresh; Mukerjee, S. K.; Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry; vol. 19; nb. 9; (1980); p. 792 - 793, View in Reaxys; Lerman, Ori; Yitzhak, Tor; Hebel, David; Rozen, Shlomo; Journal of Organic Chemistry; vol. 49; (1984); p. 806 - 813, View in Reaxys; Takakis, Ioannis M.; Hadjimihalakis, Phaedon M.; Journal of Heterocyclic Chemistry; vol. 28; nb. 3; (1991); p. 625 - 634, View in Reaxys; Ishibashi; Mino; Sakata; Inada; Ikeda; Chemical and Pharmaceutical Bulletin; vol. 39; nb. 5; (1991); p. 1148 - 1151, View in Reaxys; Ishibashi; Matsuoka; Ikeda; Chemical and Pharmaceutical Bulletin; vol. 39; nb. 7; (1991); p. 1854 - 1856, View in Reaxys; Hara, Hiroshi; Satoh, Hiroya; Hoshino, Osamu; Heterocycles; vol. 33; nb. 1; (1992); p. 43 - 46, View in Reaxys; Ishibashi, Hiroyuki; Nakatani, Hiroshi; Umei, Yoshizumi; Yamamoto, Wako; Ikeda, Masazumi; Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999); (1987); p. 589 - 594, View in Reaxys; Okwute, S. K.; Okogun, J. I.; Okorie, D. A.; Tetrahedron; vol. 40; nb. 13; (1984); p. 2541 - 2546, View in Reaxys; Ishibashi, Hiroyuki; Sato, Tatsunori; Irie, Maki; Ito, Masae; Ikeda, Masazumi; Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999); (1987); p. 1095 - 1098, View in Reaxys 8 of 35

Comment (Pharmacological Data)

Bioactivities present

Bertha, F.; Fetter, J.; Lempert, K.; Moeller, J.; Acta Chimica Academiae Scientiarum Hungaricae; vol. 111; nb. 2; (1982); p. 213 - 224, View in Reaxys; Bonner, Trevor G.; Lewis, David; Rutter, Keith; Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999); (1981); p. 1807 - 1810, View in Reaxys; Corda, Luciana; Fadda, Anna Maria; Maccioni, Antonio; Maccioni, Anna Maria; Podda, Gianni; Journal of Heterocyclic Chemistry; vol. 25; (1988); p. 311 - 314, View in Reaxys; Rudenko, A. P.; Zarubin, M. Ya.; Pragst, F.; Journal of Organic Chemistry USSR (English Translation); vol. 20; nb. 11; (1984); p. 2145 - 2165; Zhurnal Organicheskoi Khimii; vol. 20; nb. 11; (1984); p. 2356 - 2377, View in Reaxys; Cole, Edward R.; Crank, George; Minh, H. T. Hai; Australian Journal of Chemistry; vol. 33; nb. 8; (1980); p. 1553 - 1558, View in Reaxys; Doshi, Haresh; Cardis, Angeline B.; Crelling, J. Kenneth; Miller, Stephen I.; Dalton, David R.; Journal of Organic Chemistry; vol. 52; nb. 12; (1987); p. 2604 - 2608, View in Reaxys; Cambanis, Anton; Baeuml, Englbert; Mayr, Herbert; Synthesis; nb. 12; (1988); p. 961, View in Reaxys; Ishibashi; Tabata; Kobayashi; Takamuro; Ikeda; Chemical and Pharmaceutical Bulletin; vol. 39; nb. 11; (1991); p. 2878 - 2882, View in Reaxys; Elmorsy, Saad S.; Bhatt, M. V.; Pelter, Andrew; Tetrahedron Letters; vol. 33; nb. 12; (1992); p. 1657 - 1660, View in Reaxys; Hanson, A. W.; McCulloch, A. W.; McInnes, A. G.; Canadian Journal of Chemistry; vol. 64; (1986); p. 1450 - 1457, View in Reaxys; Kunitumo, Jun-ichi; Miyata, Yohko; Oshikata, Megumi; Chemical & Pharmaceutical Bulletin; vol. 33; nb. 12; (1985); p. 5245 - 5249, View in Reaxys; Hara; Hoshino; Umezawa; Chemical and Pharmaceutical Bulletin; vol. 31; nb. 2; (1983); p. 730 - 732, View in Reaxys; Torii, Sigeru; Tanaka, Hideo; Hamatani, Takeshi; Morisaki, Kazuo; Jutand, Anny; et al.; Chemistry Letters; (1986); p. 169 - 172, View in Reaxys; Tamura, Yasumitsu; Choi, Hong Dae; Mizutani, Masako; Ueda, Yuko; Ishibashi, Hiroyuki; Chemical and Pharmaceutical Bulletin; vol. 30; nb. 10; (1982); p. 3574 - 3579, View in Reaxys; Kunitomo; Oshikata; Nakayama; et al.; Chemical and Pharmaceutical Bulletin; vol. 30; nb. 12; (1982); p. 4283 - 4287, View in Reaxys; Daukshas; Gaidyalis; Pyatrauskas; Udrenaite; Gasperavichene; Raguotene; Pharmaceutical Chemistry Journal; vol. 21; nb. 5; (1988); p. 341 - 345,

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2016-08-05 15:49:11

View in Reaxys; Imakura; Okimoto; Konishi; Hisazumi; Yamazaki; Kobayashi; Yamashita; Chemical and Pharmaceutical Bulletin; vol. 40; nb. 7; (1992); p. 1691 - 1696, View in Reaxys; Ishibashi; Miki; Ikeda; Kiriyama; Chemical and Pharmaceutical Bulletin; vol. 37; nb. 12; (1989); p. 3396 - 3398, View in Reaxys; Dominguez, Esther; Lete, Esther; Villa, M. Jesus; Iriondo, Carmen; Heterocycles; vol. 22; nb. 5; (1984); p. 1217 - 1224, View in Reaxys; Hoegberg, Thomas; Khanna, Ish; Drake, Steven D.; Mitscher, Lester A.; Shen, Linus L.; Journal of Medicinal Chemistry; vol. 27; nb. 3; (1984); p. 306 - 310, View in Reaxys 9 of 35

Comment (Pharmacological Data)

Bioactivities present

Hara, Hiroshi; Hoshino, Osamu; Umezawa, Bunsuke; Heterocycles; vol. 15; nb. 2; (1981); p. 911 - 914, View in Reaxys; Podda, G.; Maccioni, A.; Fadda, A.; Daolio, S.; Traldi, P.; Vecchi, E.; Organic Mass Spectrometry; vol. 18; nb. 7; (1983); p. 318 - 320, View in Reaxys; Katritzky, Alan R.; Ellison, Joan; Frank, Judit; Rakoczy, Piroska; Radics, Lajos; Gacs-Baitz, Eszter; Organic Magnetic Resonance; vol. 16; nb. 4; (1981); p. 280 - 284, View in Reaxys; Smithson, T. L.; Duckett, J. A.; Wieser, H.; Journal of Physical Chemistry; vol. 88; nb. 6; (1984); p. 1102 - 1109, View in Reaxys; Smolinski, Stefan; Balazy, Michal; Iwamura, Hiizu; Sugawara, Tadashi; Kawada, Yuzo; Iwamura, Michiko; Bulletin of the Chemical Society of Japan; vol. 55; nb. 4; (1982); p. 1106 - 1111, View in Reaxys; Takano, Seiichi; Akiyama, Masashi; Ogasawara, Kunio; Heterocycles; vol. 20; nb. 11; (1983); p. 2237 - 2238, View in Reaxys; Matsumura, Yoshihiro; Terauchi, Jun; Yamamoto, Takashi; Konno, Takashi; Shono, Tatsuya; Tetrahedron; vol. 49; nb. 38; (1993); p. 8503 - 8512, View in Reaxys; Ansink, Harold; Cerfontain, Hans; Recueil des Travaux Chimiques des Pays-Bas; vol. 108; nb. 11; (1989); p. 395 - 403, View in Reaxys; Stender, Klaus-Wilhelm; Woelki, Norbert; Klar, Guenter; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 42; (1989); p. 111 - 114, View in Reaxys; Barr, Neal; Dyke, Stanley F.; Frost, R. L. W.; Organic Magnetic Resonance; vol. 22; nb. 5; (1984); p. 277 - 279, View in Reaxys; Behrens, Ulrich; Berges, Peer; Bieganowski, Rainer; Hinrichs, Winfried; Schiffling, Christian; Klar, Guenter; Journal of Chemical Research, Miniprint; nb. 9; (1986); p. 2801 - 2827, View in Reaxys; Mayr, Herbert; Brueggen, Uwe von der; Chemische Berichte; vol. 121; (1988); p. 339 - 346, View in Reaxys; Sokolovskii, A. V.; Zelechonok, Yu. B.; Zorin, V. V.; Zlotskii, S. S.; Rakhmankulov, D. L.; et al.; Doklady Chemistry; vol. 290; (1986); p. 411 - 413; Dokl. Akad. Nauk SSSR Ser. Khim.; vol. 290; nb. 5; (1986); p. 1130 - 1132, View in Reaxys; Romm, I. P.; Gur'yanova, E. N.; Gineitite, V. L.; Ganyushin, L. A.; Udrenaite, E. B.; J. Gen. Chem. USSR (Engl. Transl.); vol. 53; nb. 10; (1983); p. 2323 - 2332,2094 - 2101, View in Reaxys; Nifant'ev, E. E.; Ashkinadze, L. D.; Voropai, L. M.; Ruchkina, N. G.; Epshtein, L. M.; Milliaresi, E. E.; J. Gen. Chem. USSR (Engl. Transl.); vol. 55; nb. 1; (1985); p. 58 - 65,48 - 54, View in Reaxys; Sokolovskii, A. V.; Nazarov, D. V.; Rol'nik, L. Z.; Zlot-skii, S. S.; Rakhmankulov, D. L.; J. Gen. Chem. USSR (Engl. Transl.); vol. 58; nb. 6; (1988); p. 1305 - 1308,1159 - 1162, View in Reaxys; Fadda, Anna Maria; Maccioni, Anna Maria; Maccioni, Antonio; Podda, Gianni; Gazzetta Chimica Italiana; vol. 117; nb. 9; (1987); p. 555 - 556, View in Reaxys; Frey, John E.; Aiello, Theresa; Beaman, Douglas N.; Combs, Scott D.; Fu, Shi-lin; Puckett, Jeffrey J.; Journal of Organic Chemistry; vol. 59; nb. 7; (1994); p. 1817 - 1830, View in Reaxys; Matsumoto, Masakatsu; Shiono, Tamaki; Mutoh, Hiroshi; Amano, Masaaki; Arimitsu, Satoshi; Journal of the Chemical Society, Chemical Communications; nb. 1; (1995); p. 101 - 102, View in Reaxys; Yan, Bao-Zhen; Zhang, Zhao-Guo; Yuan, Han-Cheng; Wang, Long-Cheng; Xu, Jian-Hua; Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999); nb. 12; (1994); p. 2545 - 2550, View in Reaxys 10 of 35

Comment (Pharmacological Data)

Bioactivities present

Orito; Hatakeyama; Takeo; Suginome; Synthesis; nb. 10; (1995); p. 1273 - 1277, View in Reaxys; Rudenko, A. P.; Russian Journal of Organic Chemistry; vol. 30; nb. 12; (1994); p. 1946 - 1980; Zhurnal Organicheskoi Khimii; vol. 30; nb. 12; (1994); p. 1847 - 1881, View in Reaxys; Makhey, Darshan; Gatto, Barbara; Yu, Chiang; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J.; Bioorganic and Medicinal Chemistry; vol. 4; nb. 6; (1996); p. 781 - 791, View in Reaxys; Lawrence, David S.; Whitten, David G.; Photochemistry and Photobiology; vol. 64; nb. 6; (1996); p. 923 - 935, View in Reaxys; Hwu, Jih Ru; Wong, Fung Fuh; Huang, Jiann-Jyh; Tsay, Shwu-Chen; Journal of Organic Chemistry; vol. 62; nb. 12; (1997); p. 4097 - 4104, View in Reaxys; Yonezawa, Noriyuki; Hino, Tetsuo; Tokita, Yoshimi; Matsuda, Kazuhisa; Ikeda, Tomiki; Tetrahedron; vol. 53; nb. 42; (1997); p. 14287 - 14296, View in Reaxys; Noda, Yumiki; Kashima, Mikito; Tetrahedron Letters; vol. 38; nb. 35; (1997); p. 6225 - 6228, View in Reaxys; Malkov, Andrei V.; Davis, Stuart L.; Mitchell, William L.; Kocovsky, Pavel; Tetrahedron Letters; vol. 38; nb. 27; (1997); p. 4899 - 4902, View in Reaxys; Butts, Craig P.; Eberson, Lennart; Hartshorn, Michael P.; Persson, Ola; Acta Chemica Scandinavica; vol. 51; nb. 6-7; (1997); p. 718 - 732, View in Reaxys; Nishiyama, Masakazu; Yamamoto, Toshihide; Koie, Yasuyuki; Tetrahedron Letters; vol. 39; nb. 7; (1998); p. 617 - 620, View in Reaxys; Sylvain, Catherine; Wagner, Alain; Mioskowski, Charles; Synthesis; nb. 7; (1998); p. 970 - 972, View in Reaxys; Ikeda, Masazumi; Hamada, Masahiro; Yamashita, Takashi; Ikegami, Fumi; Sato, Tatsunori; Ishibashi, Hiroyuki; Synlett; nb. 11; (1998); p. 1246 - 1248, View in Reaxys; Eberson, Lennart; Hartshorn, Michael P.; McCullough, John J.; Persson, Ola; Radner, Finn; Acta Chemica Scandinavica; vol. 52; nb. 8; (1998); p. 1024 - 1028, View in Reaxys; Sinal; Bend; Chemical Research in Toxicology; vol. 8; nb. 1; (1995); p. 82 - 91, View in Reaxys; Sidhu; Marcus; Parkinson; Omiecinski; Journal of biochemical and molecular toxicology; vol. 12; nb. 5; (1998); p. 253 - 262, View in Reaxys; Bensel, Nicolas; Pevere, Virginie; Desmurs, Jean Roger; Wagner, Alain; Mioskowski, Charles; Tetrahedron Letters; vol. 40; nb. 5; (1999); p. 879 - 882, View in Reaxys; Laane; Sakurai; Klots; Meinander; Morris; Chiang; Bondoc; Journal of Molecular Structure; vol. 480-481; (1999); p. 189 196, View in Reaxys; Malkov, Andrei V.; Davis, Stuart L.; Baxendale, Ian R.; Mitchell, William L.; Kocovsky, Pavel; Journal of Organic Chemistry; vol. 64; nb. 8; (1999); p. 2751 - 2764, View in Reaxys; Vicario, Jose L.; Badia, Dolores; Dominguez, Esther; Crespo, Ana; Carrillo, Luisa; Tetrahedron Asymmetry; vol. 10; nb. 10; (1999); p.

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1947 - 1959, View in Reaxys; Sakurai; Meinander; Morris; Laane; Journal of the American Chemical Society; vol. 121; nb. 21; (1999); p. 5056 - 5062, View in Reaxys 11 of 35

Comment (Pharmacological Data)

Bioactivities present

Rudenko; Pragst; Russian Journal of Organic Chemistry; vol. 34; nb. 11; (1998); p. 1589 - 1626, View in Reaxys; Magnus; Bailey; Porter; Tetrahedron; vol. 55; nb. 49; (1999); p. 13927 - 13936, View in Reaxys; Park, Byung-Ik; Bozzelli, Joseph W.; Booty, Michael R.; Bernhard, Mary J.; Mesuere, Karel; Pettigrew, Charles A.; Shi, JiChun; Simonich, Staci L.; Environmental Science and Technology; vol. 33; nb. 15; (1999); p. 2584 - 2592, View in Reaxys; Ikeda, Masazumi; Hamada, Masahiro; Yamashita, Takashi; Matsui, Katsuaki; Sato, Tatsunori; Ishibashi, Hiroyuki; Journal of the Chemical Society - Perkin Transactions 1; nb. 14; (1999); p. 1949 - 1956, View in Reaxys; Watanabe, Makoto; Nishiyama, Masakazu; Koie, Yasuyuki; Tetrahedron Letters; vol. 40; nb. 50; (1999); p. 8837 - 8840, View in Reaxys; Pourbaix, Christelle; Carreaux, Francois; Carboni, Bertrand; Deleuze, Herve; Chemical Communications; nb. 14; (2000); p. 1275 - 1276, View in Reaxys; Bianchi, Dario A.; Kaufman, Teodoro S.; Synlett; nb. 6; (2000); p. 801 - 804, View in Reaxys; Laane, Jaan; Journal of Physical Chemistry A; vol. 104; nb. 33; (2000); p. 7715 - 7733, View in Reaxys; Gevorgyan, Vladimir; Rubin, Michael; Benson, Sharonda; Liu, Jian-Xiu; Yamamoto, Yoshinori; Journal of Organic Chemistry; vol. 65; nb. 19; (2000); p. 6179 - 6186, View in Reaxys; Fuerstner, Alois; Voigtlaender, David; Schrader, Wolfgang; Giebel, Dirk; Reetz, Manfred T.; Organic Letters; vol. 3; nb. 3; (2001); p. 417 - 420, View in Reaxys; Laane; Bondoc; Sakurai; Morris; Meinander; Choo; Journal of the American Chemical Society; vol. 122; nb. 11; (2000); p. 2628 - 2634, View in Reaxys; Bogdanovi, Borislav; Schwickardi, Manfred; Angewandte Chemie - International Edition; vol. 39; nb. 24; (2000); p. 4610 - 4612, View in Reaxys; Roy, Subhas Chandra; Guin, Chandrani; Rana, Kalyan Kumar; Maiti, Gourhari; Tetrahedron Letters; vol. 42; nb. 39; (2001); p. 6941 - 6942, View in Reaxys; Dastan, Arif; Saracoglu, Nurullah; Balci, Metin; European Journal of Organic Chemistry; nb. 18; (2001); p. 3519 - 3522, View in Reaxys; Manoso; DeShong; Journal of Organic Chemistry; vol. 66; nb. 22; (2001); p. 7449 - 7455, View in Reaxys; Yadav; Subba Reddy; Mahesh Kumar; Madan; Synlett; nb. 11; (2001); p. 1781 - 1783, View in Reaxys; Yadav; Subba Reddy; Rao, R. Srinivasa; Veerendhar; Nagaiah; Tetrahedron Letters; vol. 42; nb. 45; (2001); p. 8067 - 8070, View in Reaxys; Uchida, Mihoko; Nakajin, Shizuo; Toyoshima, Satoshi; Shinoda, Masato; Biological and Pharmaceutical Bulletin; vol. 19; nb. 4; (1996); p. 623 - 626, View in Reaxys; Yadav, Jhillu S.; Reddy, Basi V. Subba; Rao, R. Srinivasa; Kumar, S. Praveen; Nagaiah; Synlett; nb. 5; (2002); p. 784 - 786, View in Reaxys; Jeon, Sangmi; Choo, Jaebum; Kim, Sungwhan; Kwon, Younghi; Kim, Jin-Yeol; Lee, Young-Il; Chung, Hoeil; Journal of Molecular Structure; vol. 609; nb. 1-3; (2002); p. 159 - 167, View in Reaxys 12 of 35

Comment (Pharmacological Data)

Bioactivities present

Yadav; Reddy; Veerendhar; Srinivasa Rao; Nagaiah; Chemistry Letters; nb. 3; (2002); p. 318 - 319, View in Reaxys; Castagnetti, Eva; Schlosser, Manfred; Chemistry - A European Journal; vol. 8; nb. 4; (2002); p. 799 - 804, View in Reaxys; Roy, Subhas Chandra; Rana, Kalyan Kumar; Guin, Chandrani; Banerjee, Biplab; Synlett; nb. 2; (2003); p. 221 - 222, View in Reaxys; Akue-Gedu, Rufine; Al Akoum Ebrik, Sahar; Witczak-Legrand, Anne; Fasseur, Dominique; El Ghammarti, Samira; Couturier, Daniel; Decroix, Bernard; Othman, Mohamed; Debacker, Marc; Rigo, Benoit; Tetrahedron; vol. 58; nb. 45; (2002); p. 9239 - 9247, View in Reaxys; Laane, Jaan; Haller, Kristjan; Sakurai, Sachie; Morris, Kevin; Autrey, Daniel; Arp, Zane; Chiang, Whe-Yi; Combs, Amanda; Journal of Molecular Structure; vol. 650; nb. 1-3; (2003); p. 57 - 68, View in Reaxys; Cabiddu, Maria Grazia; Cadoni, Enzo; De Montis, Stefania; Fattuoni, Claudia; Melis, Stefana; Usai, Michele; Tetrahedron; vol. 59; nb. 24; (2003); p. 4383 - 4387, View in Reaxys; Tsukada, Naofumi; Yagura, Yasushige; Sato, Tetsuo; Inoue, Yoshio; Synlett; nb. 10; (2003); p. 1431 - 1434, View in Reaxys; Basavaraju; Anjanamurthy; Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry; vol. 42; nb. 4; (2003); p. 876 - 880, View in Reaxys; Belloni, Maura; Manickam; Wang, Zehn-He; Preece, Jon A.; Molecular Crystals and Liquid Crystals; vol. 399; (2003); p. 93 - 114, View in Reaxys; Yadav; Reddy; Basak; Narsaiah; Advanced Synthesis and Catalysis; vol. 346; nb. 1; (2004); p. 77 - 82, View in Reaxys; Bandgar; Makone; Synthetic Communications; vol. 34; nb. 4; (2004); p. 743 - 750, View in Reaxys; Braddock, D. Christopher; Cansell, Gemma; Hermitage, Stephen A.; Synlett; nb. 3; (2004); p. 461 - 464, View in Reaxys; Tani, Masayuki; Sakaguchi, Satoshi; Ishii, Yasutaka; Journal of Organic Chemistry; vol. 69; nb. 4; (2004); p. 1221 - 1226, View in Reaxys; Pietraperzia; Zoppi; Becucci; Droghetti; Castellucci; Chemical Physics Letters; vol. 385; nb. 3-4; (2004); p. 304 - 308, View in Reaxys; Krishna Mohan; Narender; Srinivasu; Kulkarni; Raghavan; Synthetic Communications; vol. 34; nb. 12; (2004); p. 2143 2152, View in Reaxys; Krishna Mohan; Narender; Kulkarni; Tetrahedron Letters; vol. 45; nb. 43; (2004); p. 8015 8018, View in Reaxys; Branytska, Oiena; Neumann, Ronny; Synlett; nb. 9; (2004); p. 1575 - 1576, View in Reaxys; Hanessian, Stephen; Tremblay, Martin; Organic Letters; vol. 6; nb. 25; (2004); p. 4683 - 4686, View in Reaxys; He, Yonggang; Wu, Chengyin; Kong, Wei; Chemical Physics Letters; vol. 402; nb. 1-3; (2005); p. 212 - 216, View in Reaxys; Goldoni, Luca; Cravotto, Giancarlo; Penoni, Andrea; Tollari, Stefano; Palmisano, Giovanni; Synlett; nb. 6; (2005); p. 927 - 930; Art.No: G03605ST, View in Reaxys 13 of 35

Comment (Pharmacological Data)

Bioactivities present

Onoue, Ken-Ichi; Shintou, Taichi; Zhang, Chang Shan; Itoh, Isamu; Chemistry Letters; vol. 35; nb. 1; (2006); p. 22 - 23, View in Reaxys; Kisiel, Zbigniew; Pszczolkowski, Lech; Pietraperzia; Becucci; Caminati; Meyer, Rolf; Physical Chemistry Chemical Physics; vol. 6; nb. 24; (2004); p. 5469 - 5475, View in Reaxys; Campeau, LouisCharles; Parisien, Mathieu; Jean, Annie; Fagnou, Keith; Journal of the American Chemical Society; vol. 128; nb. 2; (2006); p. 581 - 590, View in Reaxys; Lafite, Pierre; Dijols, Sylvie; Buisson, Didier; Macherey, Anne-Chris-

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tine; Zeldin, Darryl C.; Dansette, Patrick M.; Mansuy, Daniel; Bioorganic and Medicinal Chemistry Letters; vol. 16; nb. 10; (2006); p. 2777 - 2780, View in Reaxys; Esumi, Tomoyuki; Hojyo, Daisuke; Zhai, Haifeng; Fukuyama, Yoshiyasu; Tetrahedron Letters; vol. 47; nb. 24; (2006); p. 3979 - 3983, View in Reaxys; Zhang, Guofu; Liu, Renhua; Xu, Qing; Ma, Lixin; Liang, Xinmiao; Advanced Synthesis and Catalysis; vol. 348; nb. 7-8; (2006); p. 862 866, View in Reaxys; Wu, Maojiang; Sun, Qiming; Yang, Chunhao; Chen, Dongdong; Ding, Jian; Chen, Yi; Lin, Liping; Xie, Yuyuan; Bioorganic and Medicinal Chemistry Letters; vol. 17; nb. 4; (2007); p. 869 - 873, View in Reaxys; Kooistra, Floris B.; Knol, Joop; Kastenberg, Fredrik; Popescu, Lacramioara M.; Verhees, Wiljan J. H.; Kroon, Jan M.; Hummelen, Jan C.; Organic Letters; vol. 9; nb. 4; (2007); p. 551 - 554, View in Reaxys; Steinke, Nelli; Frey, Wolfgang; Baro, Angelika; Laschat, Sabine; Drees, Christina; Nimtz, Manfred; Haegele, Constanze; Giesselmann, Frank; Chemistry - A European Journal; vol. 12; nb. 4; (2006); p. 1026 - 1035, View in Reaxys; Amijs, Catelijne H. M.; Ferrer, Catalina; Echavarren, Antonio M.; Chemical Communications; nb. 7; (2007); p. 698 - 700, View in Reaxys; Ianni, Alen; Waldvogel, Siegfried R.; Synthesis; nb. 13; (2006); p. 2103 2112, View in Reaxys; Kim, Hyoungsu; Wooten, Ceshea M.; Park, Yongho; Hong, Jiyong; Organic Letters; vol. 9; nb. 20; (2007); p. 3965 - 3968, View in Reaxys; Banwell, Martin G.; Kokas, Okanya J.; Willis, Anthony C.; Organic Letters; vol. 9; nb. 18; (2007); p. 3503 - 3506, View in Reaxys; Chu, Cheng-Ming; Huang, Wan-Ju; Liu, JuTsung; Yao, Ching-Fa; Tetrahedron Letters; vol. 48; nb. 39; (2007); p. 6881 - 6885, View in Reaxys; Lafrance, Marc; Blaquiere, Nicole; Fagnou, Keith; European Journal of Organic Chemistry; nb. 5; (2007); p. 811 - 825, View in Reaxys; Yamada, Tomoyuki; Sakaguchi, Satoshi; Ishii, Yasutaka; Journal of Organic Chemistry; vol. 70; nb. 14; (2005); p. 5471 - 5474, View in Reaxys; Patent; Eli Lilly and Company; US5387681; (1995); (A1) English, View in Reaxys; Patent; L'Oreal; US4865617; (1989); (A1) English, View in Reaxys; Patent; Ortho Pharmaceutical Corporation; US4761413; (1988); (A1) English, View in Reaxys; Patent; Schering Aktiengesellschaft; US4155915; (1979); (A1) English, View in Reaxys 14 of 35

Comment (Pharmacological Data)

Bioactivities present

Patent; Vertex Pharmaceuticals, Incorporated; US6372778; (2002); (B1) English, View in Reaxys; Patent; Eli Lilly and Company; US5270329; (1993); (A1) English, View in Reaxys; Patent; Eli Lilly and Company; US6281240; (2001); (B1) English, View in Reaxys; Patent; G. D. Searle and Co.; US5968942; (1999); (A1) English, View in Reaxys; Patent; G. D. Searle and Co.; US6127556; (2000); (A1) English, View in Reaxys; Patent; G. D. Searle and Co.; US6140505; (2000); (A1) English, View in Reaxys; Patent; G.D. Searle and Co.; US5776971; (1998); (A1) English, View in Reaxys; Patent; G.D. Searle and Co.; US6143788; (2000); (A1) English, View in Reaxys; Patent; Imperial Chemical Industries PLC; US5153227; (1992); (A1) English, View in Reaxys; Patent; SmithKline Beecham Corporation; US5780483; (1998); (A1) English, View in Reaxys; Patent; Merck Patent Gesellschaft mit beschrankter Haftung; US5635107; (1997); (A1) English, View in Reaxys; Dichiarante, Valentina; Fagnoni, Maurizio; Albini, Angelo; Angewandte Chemie - International Edition; vol. 46; nb. 34; (2007); p. 6495 - 6498, View in Reaxys; Sun, Xiaoyu; Sun, Wei; Fan, Renhua; Wu, Jie; Advanced Synthesis and Catalysis; vol. 349; nb. 13; (2007); p. 2151 - 2155, View in Reaxys; Gavara, Laurent; Boisse, Thomas; Rigo, Benoit; Henichart, Jean-Pierre; Tetrahedron; vol. 64; nb. 22; (2008); p. 4999 - 5004, View in Reaxys; Wang, Zhiyong; Sun, Xiaoyu; Wu, Jie; Tetrahedron; vol. 64; nb. 22; (2008); p. 5013 - 5018, View in Reaxys; Meng, Qinghua; Sun, Yanhui; Ratovelomanana-Vidal, Virginie; Genet, Jean Pierre; Zhang, Zhaoguo; Journal of Organic Chemistry; vol. 73; nb. 10; (2008); p. 3842 - 3847, View in Reaxys; Matcha, Kiran; Ghosh, Subrata; Tetrahedron Letters; vol. 49; nb. 21; (2008); p. 3433 - 3436, View in Reaxys; Patent; Shasun Pharma Solutions Limited; US2008/154049; (2008); (A1) English, View in Reaxys; Patent; Cai, Xiong; Qian, Changgeng; Zhai, Haixiao; US2008/234314; (2008); (A1) English, View in Reaxys; Amijs, Catelijne H. M.; Lopez-Carrillo, Veronica; Raducan, Mihai; PerezGalan, Patricia; Ferrer, Catalina; Echavarren, Antonio M.; Journal of Organic Chemistry; vol. 73; nb. 19; (2008); p. 7721 - 7730, View in Reaxys 15 of 35

Comment (Pharmacological Data)

Bioactivities present

Rao, Weidong; Chan, Philip Wai Hong; Organic and Biomolecular Chemistry; vol. 6; nb. 13; (2008); p. 2426 2433, View in Reaxys; Patent; CRYSTAX PHARMACEUTICALS, S.L.; WO2009/7399; (2009); (A1) English, View in Reaxys; Patent; SCHERING CORPORATION; WO2009/14637; (2009); (A2) English, View in Reaxys; Fan, Renhua; Li, Weixun; Wang, Bing; Organic and Biomolecular Chemistry; vol. 6; nb. 24; (2008); p. 4615 - 4621, View in Reaxys; Stadler, Daniel; Bach, Thorsten; Angewandte Chemie - International Edition; vol. 47; nb. 39; (2008); p. 7557 - 7559, View in Reaxys; Moon, Jeongju; Lee, Sunwoo; Journal of Organometallic Chemistry; vol. 694; nb. 3; (2009); p. 473 - 477, View in Reaxys; Wunderlich, Stefan H.; Knochel, Paul; Angewandte Chemie International Edition; vol. 48; nb. 8; (2009); p. 1501 - 1504, View in Reaxys; Cadoni, Enzo; Perra, Efisio; Fattuoni, Claudia; Bruno, Giuseppe; Cabiddu, Maria G.; De Montis, Stefania; Cabiddu, Salvatore; Tetrahedron; vol. 65; nb. 11; (2009); p. 2279 - 2284, View in Reaxys; Cao, Chenzhong; Zhou, Zaichun; Yin, Zhiqing; Liu, Qiuhua; Organic Letters; vol. 11; nb. 8; (2009); p. 1781 - 1784, View in Reaxys; Zysman-Colman, Eli; Arias, Karla; Siegel, Jay S.; Canadian Journal of Chemistry; vol. 87; nb. 2; (2009); p. 440 - 447, View in Reaxys; Patent; Ube Industries, Ltd.; EP2119713; (2009); (A1) English, View in Reaxys; Patent; Ube Industries, Ltd.; EP2119714; (2009); (A1) English, View in Reaxys; Patent; The Jordanian Pharmaceutical Manufacturing and Medical Equipment Co.Ltd.; EP1219614; (2002); (A1) English, View in Reaxys; Dichiarante, Valentina; Fagnoni, Maurizio; Albini, Angelo; Green Chemistry; vol. 11; nb. 7; (2009); p. 942 - 945, View in Reaxys; Clement, J. Arul; Mohanakrishnan, Arasambattu K.; Tetrahedron; vol. 66; nb. 13; (2010); p. 2340 - 2350, View in Reaxys; Tang, Zhi Yong; Zhang, Yuan; Wang, Tao; Wang, Wei; Synlett; nb. 5; (2010); p. 804 - 808; Art.No: W16209ST, View in Reaxys; Xu, Wei; Zou, Jian-Ping; Zhang, Wei; Tetrahedron Letters; vol. 51; nb. 19; (2010); p. 2639 - 2643, View in Reaxys; Mo, Fanyang; Yan, Jerry Mingtao; Qiu, Di; Li, Fei; Zhang, Yan; Wang, Jianbo; Angewandte Chemie - International Edition; vol. 49; nb. 11; (2010); p. 2028 - 2032, View in Reaxys; Barelier, Sarah; Pons, Julien; Marcillat, Olivier; Lan-

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celin, Jean-Marc; Krimm, Isabelle; Journal of Medicinal Chemistry; vol. 53; nb. 6; (2010); p. 2577 - 2588, View in Reaxys; Zhang, Zhen; Shi, Min; Chemistry - A European Journal; vol. 16; nb. 26; (2010); p. 7725 - 7729, View in Reaxys 16 of 35

Comment (Pharmacological Data)

Bioactivities present

Barelier, Sarah; Pons, Julien; Gehring, Kalle; Lancelin, Jean-Marc; Krimm, Isabelle; Journal of Medicinal Chemistry; vol. 53; nb. 14; (2010); p. 5256 - 5266, View in Reaxys; Alberola, Antonio; Eisler, Dana; Less, Robert J.; Navarro-Moratalla, Efren; Rawson, Jeremy M.; Chemical Communications; vol. 46; nb. 33; (2010); p. 6114 6116, View in Reaxys; Patent; GRUeNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; SCHIENE, Klaus; DE VRY, Jean; DAMANN, Nils; FRORMANN, Sven; LESCH, Bernhard; LEE, Jeewoo; KIM, Yong-Soo; KIM, Myeong-Seop; WO2010/127855; (2010); (A1) English, View in Reaxys; Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/5284; (2004); (A1) English, View in Reaxys; Vanchura II, Britt A.; Preshlock, Sean M.; Roosen, Philipp C.; Kallepalli, Venkata A.; Staples, Richard J.; Maleczka Jr., Robert E.; Singleton, Daniel A.; Smith III, Milton R.; Chemical Communications; vol. 46; nb. 41; (2010); p. 7724 7726, View in Reaxys; Ravelli, Davide; Albini, Angelo; Fagnoni, Maurizio; Chemistry - A European Journal; vol. 17; nb. 2; (2011); p. 572 - 579, View in Reaxys; Joshi-Pangu, Amruta; Wang, Chao-Yuan; Biscoe, Mark R.; Journal of the American Chemical Society; vol. 133; nb. 22; (2011); p. 8478 - 8481, View in Reaxys; Tang, Changhua; Li, Ziyuan; Wang, Yiyun; Xu, Jinyi; Kong, Lingyi; Yao, Hequan; Wu, Xiaoming; Tetrahedron Letters; vol. 52; nb. 26; (2011); p. 3275 - 3278, View in Reaxys; Liu, An-Hua; He, Liang-Nian; Hua, Fang; Yang, Zhen-Zhen; Huang, Cheng-Bin; Yu, Bing; Li, Bin; Advanced Synthesis and Catalysis; vol. 353; nb. 17; (2011); p. 3187 - 3195, View in Reaxys; Ravelli, Davide; Montanaro, Sara; Zema, Michele; Fagnoni, Maurizio; Albini, Angelo; Advanced Synthesis and Catalysis; vol. 353; nb. 18; (2011); p. 3295 - 3300, View in Reaxys; Comegna, Daniela; Dellagreca, Marina; Rosaria Iesce; Previtera, Lucio; Zarrelli, Armando; Zuppolini, Simona; Organic and Biomolecular Chemistry; vol. 10; nb. 6; (2012); p. 1219 - 1224, View in Reaxys; Shang, Xiaojie; Xiong, Yun; Zhang, Yuexia; Zhang, Lei; Liu, Zhongquan; Synlett; nb. 2; (2012); p. 259 - 262, View in Reaxys; Imamoto, Tsuneo; Tamura, Ken; Zhang, Zhenfeng; Horiuchi, Yumi; Sugiya, Masashi; Yoshida, Kazuhiro; Yanagisawa, Akira; Gridnev, Ilya D.; Journal of the American Chemical Society; vol. 134; nb. 3; (2012); p. 1754 - 1769, View in Reaxys; Song, Ha Yun; Yang, Ji Yeon; Suh, Joo Won; Lee, Hoi Seon; Journal of Agricultural and Food Chemistry; vol. 59; nb. 14; (2011); p. 7759 - 7764, View in Reaxys; Kumbaraci, Volkan; Aydogan, Binnur; Talinli, Naciye; Yagci, Yusuf; Journal of Polymer Science, Part A: Polymer Chemistry; vol. 50; nb. 13; (2012); p. 2612 - 2618, View in Reaxys; Yang, Jinliang; Xu, Fei; Shi, Suqing; Nie, Jun; Photochemical and Photobiological Sciences; vol. 11; nb. 8; (2012); p. 1377 - 1382, View in Reaxys; Leung, Joyce C.; Geary, Laina M.; Chen, Te-Yu; Zbieg, Jason R.; Krische, Michael J.; Journal of the American Chemical Society; vol. 134; nb. 38; (2012); p. 15700 - 15703, View in Reaxys; Regenbrecht, Carolin; Waldvogel, Siegfried R.; Beilstein Journal of Organic Chemistry; vol. 8; (2012); p. 1721 - 1724,4, View in Reaxys; Liu, An-Hua; Ma, Ran; Zhang, Meng; He, Liang-Nian; Catalysis Today; vol. 194; nb. 1; (2012); p. 38 - 43, View in Reaxys; Murugan, Kaliyappan; Huang, Da-Wei; Chien, Yu-Ting; Liu, Shiuh-Tzung; Tetrahedron; vol. 69; nb. 1; (2013); p. 268 - 273, View in Reaxys 17 of 35

Comment (Pharmacological Data)

Bioactivities present

Patent; Doi, Takashi; Yoshida, Yoshihiro; Douyama, Daisuke; Katsura, Ryousuke; Fujitsu, Satoru; Yasuda, Shinji; Kimura, Keisuke; Oomori, Kiyoshi; US2012/323021; (2012); (A1) English, View in Reaxys; Shrestha, Ruja; Dorn, Stephanie C. M.; Weix, Daniel J.; Journal of the American Chemical Society; vol. 135; nb. 2; (2013); p. 751 - 762, View in Reaxys; Liu, Dong; Liu, Chao; Li, Heng; Lei, Aiwen; Angewandte Chemie - International Edition; vol. 52; nb. 16; (2013); p. 4453 - 4456, View in Reaxys; Zhang, Shuai; Song, Feijie; Zhao, Dongbing; You, Jingsong; Chemical Communications; vol. 49; nb. 40; (2013); p. 4558 - 4560, View in Reaxys; Yang, Yu-Dong; Iwamoto, Kanji; Tokunaga, Etsuko; Shibata, Norio; Chemical Communications; vol. 49; nb. 48; (2013); p. 5510 5512, View in Reaxys; Ryu, Ilhyong; Tani, Akihiro; Fukuyama, Takahide; Ravelli, Davide; Montanaro, Sara; Fagnoni, Maurizio; Organic Letters; vol. 15; nb. 10; (2013); p. 2554 - 2557, View in Reaxys; Hansch; Journal of medicinal chemistry; vol. 11; nb. 5; (1968); p. 920 - 924, View in Reaxys; Bjorsvik, Hans-Rene; Liguori, Lucia; Minisci, Francesco; Organic Process Research and Development; vol. 4; nb. 6; (2000); p. 534 - 543, View in Reaxys; Storace, Louis; Anzalone, Luigi; Confalone, Pat N.; Davis, Wayne P.; Fortunak, Joseph M.; Giangiordano, Mark; Haley Jr., James J.; Kamholz, Kenneth; Li, Hui-Yin; Ma, Philip; Nugent, William A.; Parsons Jr., Rodney L.; Sheeran, Patrick J.; Silverman, Charlotte E.; Waltermire, Robert E.; Wood, Christopher C.; Organic Process Research and Development; vol. 6; nb. 1; (2002); p. 54 - 63, View in Reaxys; Komagai; Schmitz; Cho; Xenobiotica; vol. 22; nb. 4; (1992); p. 395 - 403, View in Reaxys; Patent; ENDURA S.P.A.; GOBBI, Carlotta; BORZATTA, Valerio; CAPPARELLA, Elisa; WO2013/135806; (2013); (A1) English, View in Reaxys; Hazra, Sunit; Hajra, Saumen; RSC Advances; vol. 3; nb. 45; (2013); p. 22834 - 22836, View in Reaxys; Pinalli, Roberta; Barboza, Tahnee; Bianchi, Federica; Massera, Chiara; Ugozzoli, Franco; Dalcanale, Enrico; Supramolecular Chemistry; vol. 25; nb. 9-11; (2013); p. 682 - 687, View in Reaxys; Ernest C. Hagan; Paul M. Jenner; Wm. I. Jones; O. Garth Fitzhugh; Eleanor L. Long; J. G. Brouwer; Willis K. Webb; Toxicology and applied pharmacology; vol. 7; (1965); p. 18, View in Reaxys; Min, Hongkeun; Lee, Sunyoung; Park, Minhan; Hwang, Jinil; Jung, Hyun Min; Lee, Sunwoo; Journal of Organometallic Chemistry; vol. 755; (2014); p. 7 - 11, View in Reaxys; More, Nagnath Yadav; Jeganmohan, Masilamani; Organic Letters; vol. 16; nb. 3; (2014); p. 804 - 807, View in Reaxys; Reddel, Jordan C. T.; Lutz, Kelly E.; Diagne, Abdallah B.; Thomson, Regan J.; Angewandte Chemie - International Edition; vol. 53; nb. 5; (2014); p. 1395 - 1398; Angew. Chem.; vol. 126; nb. 05; (2014); p. 1419 - 1422,4, View in Reaxys; Chen, Cheng; Hartwig, John F.; Science; vol. 343; nb. 6173; (2014); p. 853 - 857, View in Reaxys;

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2016-08-05 15:49:11

Santavy et al.; Acta Univ. Palack. Olomuc Suppl. XIII; p. 15 - 18, View in Reaxys; Liu, Dong; Liu, Chao; Li, Heng; Lei, Aiwen; Chemical Communications; vol. 50; nb. 27; (2014); p. 3623 - 3626, View in Reaxys 18 of 35

Comment (Pharmacological Data)

Bioactivities present

Gigant, Nicolas; Baeckvall, Jan-E.; Organic Letters; vol. 16; nb. 6; (2014); p. 1664 - 1667, View in Reaxys; Gigant, Nicolas; Baeckvall, Jan-E.; Chemistry - A European Journal; vol. 20; nb. 20; (2014); p. 5890 - 5894, View in Reaxys; Patent; BIOENERGENIX; McCall, John M.; Romero, Donna L.; US2014/128392; (2014); (A1) English, View in Reaxys; Rafiq, Settu Muhamad; Sivasakthikumaran, Ramakrishnan; Mohanakrishnan, Arasambattu K.; Organic Letters; vol. 16; nb. 10; (2014); p. 2720 - 2723, View in Reaxys; Tan, Boon-Hong; Yoshikai, Naohiko; Organic Letters; vol. 16; nb. 12; (2014); p. 3392 - 3395, View in Reaxys; Zhou, Liangliang; Tang, Shan; Qi, Xiaotian; Lin, Caitao; Liu, Kun; Liu, Chao; Lan, Yu; Lei, Aiwen; Organic Letters; vol. 16; nb. 12; (2014); p. 3404 - 3407, View in Reaxys; Umesha, Basavaiah; Basavaraju, Yeriyur Basavaiah; Medicinal Chemistry Research; vol. 23; nb. 8; (2014); p. 3744 - 3751, View in Reaxys; Maibunkaew, Tapanee; Thongsornkleeb, Charnsak; Tummatorn, Jumreang; Bunrit, Anon; Ruchirawat, Somsak; Synlett; vol. 25; nb. 12; (2014); p. 1769 - 1775; Art.No: ST-2014-U0267-L, View in Reaxys; Patent; NIPPON CHEMICAL INDUSTRIAL CO., LTD.; Zhang, Zhenfeng; Imamoto, Tsuneo; Tamura, Ken; US2014/213800; (2014); (A1) English, View in Reaxys; Chu, Xue-Qiang; Meng, Hua; Zi, You; Xu, Xiao-Ping; Ji, Shun-Jun; Chemical Communications; vol. 50; nb. 68; (2014); p. 9718 9721, View in Reaxys; Patent; Dow AgroSciences LLC; Eckelbarger, Joseph D.; Epp, Jeffrey B.; Fischer, Lindsey G.; Lowe, Christian T.; Petkus, Jeff; Roth, Joshua; Satchivi, Norbert M.; Schmitzer, Paul R.; Siddall, Thomas L.; US2014/274701; (2014); (A1) English, View in Reaxys; Xi, Yumeng; Su, Yijin; Dong, Boliang; McClain, Edward J.; Shi, Xiaodong; Yu, Zhaoyuan; Lan, Yu; Angewandte Chemie, International Edition; vol. 53; nb. 37; (2014); p. 9817 - 9821,5; Angewandte Chemie; vol. 126; nb. 37; (2014); p. 9975 - 9979,5, View in Reaxys; Guo, Shi-Huan; Xing, Sheng-Zhu; Mao, Shuai; Gao, Ya-Ru; Chen, Wen-Liang; Wang, Yong-Qiang; Tetrahedron Letters; vol. 55; nb. 49; (2014); p. 6718 - 6720, View in Reaxys; Wang, Lin; Wei, Xiao-Jing; Lei, Wen-Long; Chen, Han; Wu, Li-Zhu; Liu, Qiang; Chemical Communications; vol. 50; nb. 100; (2014); p. 15916 - 15919, View in Reaxys; Ma, Ran; Huang, Cheng-Bin; Liu, An-Hua; Li, Xue-Dong; He, Liang-Nian; Catalysis Science and Technology; vol. 4; nb. 12; (2014); p. 4308 - 4312, View in Reaxys; Kinthada, Lakshmana K.; Ghosh, Santanu; Babu, K. Naresh; Sharique, Mohd.; Biswas, Soumava; Bisai, Alakesh; Organic and Biomolecular Chemistry; vol. 12; nb. 41; (2014); p. 8152 - 8173, View in Reaxys; Varun, Begur Vasanthkumar; Prabhu, Kandikere Ramaiah; Journal of Organic Chemistry; vol. 79; nb. 20; (2014); p. 9655 - 9668, View in Reaxys; Cheng, Chen; Hartwig, John F.; Journal of the American Chemical Society; vol. 137; nb. 2; (2015); p. 592 - 595, View in Reaxys; Zhang, Ruo-Yi; Xi, Long-Yi; Zhang, Lei; Liang, Shuai; Chen, Shan-Yong; Yu, Xiao-Qi; RSC Advances; vol. 4; nb. 97; (2014); p. 54349 - 54353, View in Reaxys; Ou, Wenhua; Huang, Hong; Asian Journal of Chemistry; vol. 27; nb. 3; (2015); p. 1175 - 1176, View in Reaxys 19 of 35

Comment (Pharmacological Data)

Bioactivities present

More, Nagnath Yadav; Jeganmohan, Masilamani; Chemistry - A European Journal; vol. 21; nb. 3; (2015); p. 1337 - 1342, View in Reaxys; Du, Peng; Li, Huihuang; Wang, Yaxiong; Cheng, Jiang; Wan, Xiaobing; Organic Letters; vol. 16; nb. 24; (2014); p. 6350 - 6353, View in Reaxys; Patent; ENDURA S.P.A.; Gobbi, Carlotta; Borzatta, Valerio; Capparella, Elisa; US2015/38465; (2015); (A1) English, View in Reaxys; Pohjoispää, Monika; Mera-Adasme, Ral; Sundholm, Dage; Heikkinen, Sami; Hase, Tapio; Wähälä, Kristiina; Journal of Organic Chemistry; vol. 79; nb. 21; (2014); p. 10636 - 10640, View in Reaxys; Aksenov, Alexander V.; Smirnov, Alexander N.; Aksenov, Nicolai A.; Aksenova, Inna V.; Matheny, Jonathon P.; Rubin, Michael; RSC Advances; vol. 5; nb. 12; (2015); p. 8647 - 8656, View in Reaxys; Asquith, Christopher R.M.; Meli, Marina L.; Konstantinova, Lidia S.; Laitinen, Tuomo; Poso, Antti; Rakitin, Oleg A.; Hofmann-Lehmann, Regina; Allenspach, Karin; Hilton, Stephen T.; Bioorganic and Medicinal Chemistry Letters; vol. 25; nb. 6; (2015); p. 1352 - 1355, View in Reaxys; Zhou, Wei; Qian, Ping; Zhao, Jincan; Fang, Hong; Han, Jianlin; Pan, Yi; Organic Letters; vol. 17; nb. 5; (2015); p. 1160 - 1163, View in Reaxys; Gigant, Nicolas; Quintin, Francois; Bäckvall, Jan-E.; Journal of Organic Chemistry; vol. 80; nb. 5; (2015); p. 2796 - 2803, View in Reaxys; Tamura, Toshiyuki; Moriyama, Katsuhiko; Togo, Hideo; European Journal of Organic Chemistry; vol. 2015; nb. 9; (2015); p. 2023 - 2029, View in Reaxys; Patent; THE REGENTS OF UNIVERSITY OF CALIFORNIA; HARTWIG, John, F.; CHENG, Chen; WILSON, Tyler; WO2015/35325; (2015); (A1) English, View in Reaxys; Wang, Jian; Chen, Shu-Bin; Wang, Shu-Guang; Li, Jing-Hua; Australian Journal of Chemistry; vol. 68; nb. 3; (2015); p. 513 - 517, View in Reaxys; Zhang, Bingyu; Lv, Chao; Li, Weibo; Cui, Zhiming; Chen, Dongdong; Cao, Fangjun; Miao, Fang; Zhou, Le; Chemical and Pharmaceutical Bulletin; vol. 63; nb. 4; (2015); p. 255 - 262, View in Reaxys; Belhomme, Marie-Charlotte; Bayle, Alexandre; Poisson, Thomas; Pannecoucke, Xavier; European Journal of Organic Chemistry; vol. 2015; nb. 8; (2015); p. 1719 - 1726, View in Reaxys; Koura, Minoru; Matsuda, Takayuki; Okuda, Ayumu; Watanabe, Yuichiro; Yamaguchi, Yuki; Kurobuchi, Sayaka; Matsumoto, Yuuki; Shibuya, Kimiyuki; Bioorganic and Medicinal Chemistry Letters; vol. 25; nb. 13; (2015); p. 2668 - 2674, View in Reaxys; Shin, Seohyun; Park, Youngchul; Kim, Cheol-Eui; Son, JeongYu; Lee, Phil Ho; Journal of Organic Chemistry; vol. 80; nb. 11; (2015); p. 5859 - 5869, View in Reaxys; Selvi, Thangavel; Srinivasan, Kannupal; Advanced Synthesis and Catalysis; vol. 357; nb. 9; (2015); p. 2111 - 2118, View in Reaxys; Gu, Lijun; Jin, Cheng; Liu, Jiyan; Green Chemistry; vol. 17; nb. 7; (2015); p. 3733 - 3736, View in Reaxys; Harada, Kenichi; Kubo, Miwa; Horiuchi, Hiroki; Ishii, Akiko; Esumi, Tomoyuki; Hioki, Hideaki; Fukuyama, Yoshiyasu; Journal of Organic Chemistry; vol. 80; nb. 14; (2015); p. 7076 - 7088, View in Reaxys; Xing, Siyang; Ren, Jing; Wang, Kui; Cui, Hong; Li, Wenrui; Yan, Han; Tetrahedron; vol. 71; nb. 36; (2015); p. 6290 - 6299; Art.No: 26848, View in Reaxys; Qian, Ping; Du, Bingnan; Zhou, Jie; Mei, Haibo; Han, Jianlin; Pan, Yi; RSC Advances; vol. 5; nb. 80; (2015); p. 64961 - 64965, View in Reaxys

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20 of 35

Comment (Pharmacological Data)

Bioactivities present

Morizur, Vincent; Szafranek, Jessica; Bonhomme, Dominique; Olivero, Sandra; Desmurs, Jean Roger; Duach, Elisabet; Tetrahedron; vol. 71; nb. 38; (2015); p. 6813 - 6817, View in Reaxys; Wang, Chenyang; Mi, Xia; Li, Qingrui; Li, Yabo; Huang, Mengmeng; Zhang, Jianye; Wu, Yusheng; Wu, Yangjie; Tetrahedron; vol. 71; nb. 38; (2015); p. 6689 - 6693, View in Reaxys; Eliasen, Anders M.; Christy, Mitchell; Claussen, Karin R.; Besandre, Ronald; Thedford, Randal P.; Siegel, Dionicio; Organic Letters; vol. 17; nb. 18; (2015); p. 4420 - 4423, View in Reaxys; Jouvin, Kvin; Matheis, Christian; Goossen, Lukas J.; Chemistry - A European Journal; vol. 21; nb. 41; (2015); p. 14324 - 14327, View in Reaxys; Feng, Taotao; Chen, Weilin; Li, Dongdong; Lin, Hongzhi; Liu, Fang; Bao, Qichao; Lei, Yonghua; Zhang, Xiaojin; Xu, Xiaoli; Guo, Xiaoke; You, Qidong; Sun, Haopeng; RSC Advances; vol. 5; nb. 101; (2015); p. 82936 - 82946, View in Reaxys; Barker, Graeme; Webster, Stacey; Johnson, David G.; Curley, Rachel; Andrews, Matthew; Young, Paul C.; MacGregor, Stuart A.; Lee, Ai-Lan; Journal of Organic Chemistry; vol. 80; nb. 20; (2015); p. 9807 - 9816, View in Reaxys; Yang, Qingjing; Choy, Pui Ying; Fu, Wai Chung; Fan, Baomin; Kwong, Fuk Yee; Journal of Organic Chemistry; vol. 80; nb. 21; (2015); p. 11193 11199, View in Reaxys; Bonassi, Filippo; Ravelli, Davide; Protti, Stefano; Fagnoni, Maurizio; Advanced Synthesis and Catalysis; vol. 357; nb. 16-17; (2015); p. 3687 - 3695, View in Reaxys; Chang, Meng-Yang; Cheng, YuChieh; Organic Letters; vol. 18; nb. 3; (2016); p. 608 - 611, View in Reaxys; Jung, Jaehun; Kim, Eunjin; You, Youngmin; Cho, Eun Jin; Advanced Synthesis and Catalysis; vol. 356; nb. 13; (2014); p. 2741 - 2748, View in Reaxys; Liu, Chun; Oblak, E. Zachary; Vander Wal, Mark N.; Dilger, Andrew K.; Almstead, Danielle K.; MacMillan, David W.C.; Journal of the American Chemical Society; vol. 138; nb. 7; (2016); p. 2134 - 2137, View in Reaxys; Lee, Kang-Sang; Katsoulis, Dimitris; Choi, Jongwook; ACS Catalysis; vol. 6; nb. 3; (2016); p. 1493 - 1496, View in Reaxys; Alam, Md. Iqbal; Alam, Mohammed A.; Alam, Ozair; Nargotra, Amit; Taneja, Subhash Chandra; Koul, Surrinder; European Journal of Medicinal Chemistry; vol. 114; (2016); p. 209 - 219, View in Reaxys; Bergami, Matteo; Protti, Stefano; Ravelli, Davide; Fagnoni, Maurizio; Advanced Synthesis and Catalysis; vol. 358; nb. 7; (2016); p. 1164 - 1172, View in Reaxys; Rao, Maddali L. N.; Murty, Venneti N.; European Journal of Organic Chemistry; vol. 2016; nb. 12; (2016); p. 2177 - 2186, View in Reaxys; Murphy, John J.; Bastida, David; Paria, Suva; Fagnoni, Maurizio; Melchiorre, Paolo; Nature; vol. 532; nb. 7598; (2016); p. 218 - 222, View in Reaxys; Gorbunov, Evgeny B.; Rusinov, Gennady L.; Ulomsky, Evgeny N.; Rusinov, Vladimir L.; Charushin, Valery N.; Chupakhin, Oleg N.; Tetrahedron Letters; vol. 57; nb. 21; (2016); p. 2303 - 2305, View in Reaxys; Chang, Meng-Yang; Huang, Yi-Hsuan; Wang, Heui-Sin; Tetrahedron; vol. 72; nb. 22; (2016); p. 3022 - 3031, View in Reaxys; Dryzhakov, Marian; Moran, Joseph; ACS Catalysis; vol. 6; nb. 6; (2016); p. 3670 - 3673, View in Reaxys 21 of 35

Comment (Pharmacological Data)

physiological behaviour discussed

Feng, Taotao; Chen, Weilin; Li, Dongdong; Lin, Hongzhi; Liu, Fang; Bao, Qichao; Lei, Yonghua; Zhang, Xiaojin; Xu, Xiaoli; Guo, Xiaoke; You, Qidong; Sun, Haopeng; RSC Advances; vol. 5; nb. 101; (2015); p. 82936 82946, View in Reaxys 22 of 35

Effect (Pharmacological Data)

miticidal

Species or Test-System (Pharmacological Data)

Dermatophagoides farinae

Kind of Dosing (Pharmacological Data)

title comp. dissolved in acetone

Further Details (Pharmacological Data)

impregnated fabric disk assay; lethal concentration (LC)

Type (Pharmacological Data)

LC50

Value of Type (Pharmacological Data)

18.6 μg/cm2

Song, Ha Yun; Yang, Ji Yeon; Suh, Joo Won; Lee, Hoi Seon; Journal of Agricultural and Food Chemistry; vol. 59; nb. 14; (2011); p. 7759 - 7764, View in Reaxys 23 of 35

Effect (Pharmacological Data)

miticidal

Species or Test-System (Pharmacological Data)

Dermatophagoides pteronyssinus

Kind of Dosing (Pharmacological Data)

title comp. dissolved in acetone

Further Details (Pharmacological Data)

impregnated fabric disk assay; lethal concentration (LC)

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Type (Pharmacological Data)

LC50

Value of Type (Pharmacological Data)

14.6 μg/cm2

Song, Ha Yun; Yang, Ji Yeon; Suh, Joo Won; Lee, Hoi Seon; Journal of Agricultural and Food Chemistry; vol. 59; nb. 14; (2011); p. 7759 - 7764, View in Reaxys 24 of 35

Effect (Pharmacological Data)

miticidal

Species or Test-System (Pharmacological Data)

Tyrophagus putrescentiae

Kind of Dosing (Pharmacological Data)

title comp. dissolved in acetone

Further Details (Pharmacological Data)

impregnated fabric disk assay; lethal concentration (LC)

Type (Pharmacological Data)

LC50

Value of Type (Pharmacological Data)

9.4 μg/cm2

Song, Ha Yun; Yang, Ji Yeon; Suh, Joo Won; Lee, Hoi Seon; Journal of Agricultural and Food Chemistry; vol. 59; nb. 14; (2011); p. 7759 - 7764, View in Reaxys 25 of 35

Effect (Pharmacological Data)

protein binding affinity

Species or Test-System (Pharmacological Data)

recombinant His6-tagged Bcl-xL protein of human

Concentration (Pharmacological Data)

600 μmol/l

Kind of Dosing (Pharmacological Data)

dissolved in DMSO-d6

Further Details (Pharmacological Data)

protein with deletions in C-terminus (AA 197 - 233) and internal loop between α-helix 1 and α-helix 2 (AA 45 - 84) was used in assay

Results

molecular target: Bcl-xL protein

Barelier, Sarah; Pons, Julien; Gehring, Kalle; Lancelin, Jean-Marc; Krimm, Isabelle; Journal of Medicinal Chemistry; vol. 53; nb. 14; (2010); p. 5256 - 5266, View in Reaxys 26 of 35

Effect (Pharmacological Data)

protein binding affinity

Species or Test-System (Pharmacological Data)

recombinant His6-tagged Bcl-w protein of human

Concentration (Pharmacological Data)

600 μmol/l

Kind of Dosing (Pharmacological Data)

dissolved in DMSO-d6

Further Details (Pharmacological Data)

protein lacking last C-terminal α-helix 8 (AA 1-154) was used in assay

Results

molecular target: Bcl-w protein

Barelier, Sarah; Pons, Julien; Gehring, Kalle; Lancelin, Jean-Marc; Krimm, Isabelle; Journal of Medicinal Chemistry; vol. 53; nb. 14; (2010); p. 5256 - 5266, View in Reaxys 27 of 35

Effect (Pharmacological Data)

enzyme; induction of

Species or Test-System (Pharmacological Data)

primary rat hepatocyte culture

Concentration (Pharmacological Data)

1 - 500 μmol/l

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Kind of Dosing (Pharmacological Data)

1, 10, 25, 100, 500 μM

Exposure Period (Pharmacological Data)

24 - 72 h

Method (Pharmacological Data)

primary rat hepatocytes; title comp. effect on CYP2B1, 2B2, 3A1, 1A1, 1A2 and mEH gene expression assessment; dose-response and time-course relationships; Western blot analysis; slot-blot quantification; digital scanning densiometry

Further Details (Pharmacological Data)

cell culturing for 48 h prior to addition of increasing concns. of title comp.; incubation for 24 or 72 h; total RNA and apoprotein isolating; hybridization with specific 32P-radiolabeled oligonucleotides; apoproteins by immunochemical analysis

Comment (Pharmacological Data)

No effect

Sidhu; Marcus; Parkinson; Omiecinski; Journal of biochemical and molecular toxicology; vol. 12; nb. 5; (1998); p. 253 - 262, View in Reaxys 28 of 35

Effect (Pharmacological Data)

antioxidant

Species or Test-System (Pharmacological Data)

Wistar rat liver mitochondria

Sex

male

Method (Pharmacological Data)

in vitro; effect on ascorbate/Fe2+-induced lipid peroxidation assayed; Tris-HCl buffer, pH 7.4; sucrose; 10 μM FeSO4; 40 μM sodium ascorbate; 37 deg C; incub. for 20 min; lipid peroxidation assessed by measuring oxygen uptake

Further Details (Pharmacological Data)

dl-α-tocopherol with IC50 value of 16 μM used as positive control

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

> 100 μmol/l

Uchida, Mihoko; Nakajin, Shizuo; Toyoshima, Satoshi; Shinoda, Masato; Biological and Pharmaceutical Bulletin; vol. 19; nb. 4; (1996); p. 623 - 626, View in Reaxys 29 of 35

Effect (Pharmacological Data)

antioxidant

Species or Test-System (Pharmacological Data)

Wistar rat liver microsomes

Sex

male

Method (Pharmacological Data)

in vitro; effect on NADPH-induced lipid peroxidation assayed; 50 mM potassium phosphate buffer, pH 7.4; 10 μM FeSO4; 20 mM NaCl; NADPH-generating system; 37 deg C; incub. for 7.5 min; lipid peroxidation measured by TBA method

Further Details (Pharmacological Data)

TBA: thiobarbituric acid; dl-α-tocopherol with IC50 value of > 1000 μM used as positive control

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

> 1000 μmol/l

Uchida, Mihoko; Nakajin, Shizuo; Toyoshima, Satoshi; Shinoda, Masato; Biological and Pharmaceutical Bulletin; vol. 19; nb. 4; (1996); p. 623 - 626, View in Reaxys 30 of 35

Effect (Pharmacological Data)

antioxidant

Species or Test-System (Pharmacological Data)

Wistar rat liver microsomes

Sex

male

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Method (Pharmacological Data)

in vitro; effect on CCl4-induced lipid peroxidation assayed; 50 mM potassium phosphate buffer, pH 7.4; 3.4 mM CCl4; 20 mM NaCl; 0.6 mM EDTA; NADPH-generating system; 37 deg C; incub. for 7.5 min; lipid peroxidation measured by TBA method

Further Details (Pharmacological Data)

TBA: thiobarbituric acid; dl-α-tocopherol with IC50 value of 22 μM used as positive control

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

> 1000 μmol/l

Uchida, Mihoko; Nakajin, Shizuo; Toyoshima, Satoshi; Shinoda, Masato; Biological and Pharmaceutical Bulletin; vol. 19; nb. 4; (1996); p. 623 - 626, View in Reaxys 31 of 35

Effect (Pharmacological Data)

antioxidant

Species or Test-System (Pharmacological Data)

lecithin liposomes

Method (Pharmacological Data)

in vitro; effect on Fe2+-induced lipid peroxidation assayed; 50 mM potassium phosphate buffer, pH 7.4; 1 mM FeSO4; 25 deg C; incub. for 60 min; lipid peroxidation measured by TBA method

Further Details (Pharmacological Data)

TBA: thiobarbituric acid; dl-α-tocopherol with IC50 value of 18 μM used as positive control

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

31 μmol/l

Uchida, Mihoko; Nakajin, Shizuo; Toyoshima, Satoshi; Shinoda, Masato; Biological and Pharmaceutical Bulletin; vol. 19; nb. 4; (1996); p. 623 - 626, View in Reaxys 32 of 35

Effect (Pharmacological Data)

metabolic/pathway

Species or Test-System (Pharmacological Data)

pulmonary microsomes of Hartley guinea pigs

Sex

male

Concentration (Pharmacological Data)

200 mmol/l

Exposure Period (Pharmacological Data)

35 min

Method (Pharmacological Data)

pulmonary microsomes, from untreated animals (250-300 g); cytochrome P450 detd. spect.; isozyme-selective metabolic intermediate (MI) complex with title comp.

Further Details (Pharmacological Data)

1 mg/mL pulmonary microsomal protein with title comp. in Me2SO soln. 1 mM NADP(H) at 25 deg C for 30 min; MI complex formation detd. spect. (455-460 nm)

Results

complex formation detected with title comp. in comparable degree with microsomes from liver

Sinal; Bend; Chemical Research in Toxicology; vol. 8; nb. 1; (1995); p. 82 - 91, View in Reaxys 33 of 35

Effect (Pharmacological Data)

metabolic/pathway

Species or Test-System (Pharmacological Data)

hepatic microsomes of Hartley guinea pigs

Sex

male

Concentration (Pharmacological Data)

200 mmol/l

Exposure Period (Pharmacological Data)

5-6d

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Method (Pharmacological Data)

hepatic microsomes from animals (250-300 g) treated with 80 mg/kg phenobarbital i.p. (PB) in 2 percent saline for 4 ds, on 5th d sacrificed; sp. cytochrome P450 detd. spect.; isozyme-selective metabolic intermediate (MI) complex with title comp.

Further Details (Pharmacological Data)

1 mg/mL hepatic microsomal protein with title comp. and 1 mM NADP(H) incubated at 37 deg C for 45 min then with 50 μM potassium ferricyanide for 45 min; complex dissociation folloved by 5 min period detd. spect. (455-460 nm)

Results

no loss in absorbance; no dissociation of MI complex

Sinal; Bend; Chemical Research in Toxicology; vol. 8; nb. 1; (1995); p. 82 - 91, View in Reaxys 34 of 35

Effect (Pharmacological Data)

metabolic/pathway

Species or Test-System (Pharmacological Data)

hepatic microsomes of Hartley guinea pigs

Sex

male

Concentration (Pharmacological Data)

200 mmol/l

Exposure Period (Pharmacological Data)

5-6d

Method (Pharmacological Data)

Further Details (Pharmacological Data)

1 mg/mL hepatic microsomal protein with title comp. and 1 mM NADP(H) incubated at 25 deg C; NADP(H)-dependent MI complex detd. spect. (455-460 nm)

Results

no appreciable effect of washing process on stability of MI complex formed in presence of NADP(H) 10 percent loss

Sinal; Bend; Chemical Research in Toxicology; vol. 8; nb. 1; (1995); p. 82 - 91, View in Reaxys 35 of 35

Effect (Pharmacological Data)

metabolic/pathway

Species or Test-System (Pharmacological Data)

hepatic microsomes of Hartley guinea pigs

Sex

male

Concentration (Pharmacological Data)

10 - 500 mmol/l

Exposure Period (Pharmacological Data)

5-6d

Method (Pharmacological Data)

hepatic microsomes from animals (250-300 g) treated with 80 mg/kg phenobarbital i.p. (PB) in 2 percent saline for 4 d, on 5th d sacrificed; sp. cytochrome P450 detd. spect.; isozyme-selective metabolic intermediate (MI) complex with title comp.

Further Details (Pharmacological Data)

1 mg/mL hepatic microsomal protein with various concs. of title comp. and 1 mM NADP(H) incubated at 25 deg C; NADP(H)-dependent MI complex detd. spect. (455-460 nm)

Type (Pharmacological Data)

apparent kinetic constant Km

Value of Type (Pharmacological Data)

338 mmol/l

Results

apparent kinetic constants in absence of NADP(H) Ks 16 μM; ΔAmax 0.047; resuspension and resedimentation of microsomes by washing MI complex with title comp. not detected

Sinal; Bend; Chemical Research in Toxicology; vol. 8; nb. 1; (1995); p. 82 - 91, View in Reaxys

Reaxys ID 28729722 View in Reaxys

2/6

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Chemical Name: benzo[d][1,3]dioxole-5-d Linear Structure Formula: C7H5 (2)HO2 Molecular Formula: C7H6O2 Molecular Weight: 123.115 InChI Key: FTNJQNQLEGKTGD-MICDWDOJSA-N Note:

O 2H

Substance Label (1) Label References d-7f

Crystal Property Description (1) Colour & Other References Properties colourless

NMR Spectroscopy (2) 1 of 2

Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)

Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]

300

Location

supporting information

Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)

13C

Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]

75.5

Location

supporting information

Description (IR Spectroscopy)

Bands

Barker, Graeme; Webster, Stacey; Johnson, David G.; Curley, Rachel; Andrews, Matthew; Young, Paul C.; MacGregor, Stuart A.; Lee, Ai-Lan; Journal of Organic Chemistry; vol. 80; nb. 20; (2015); p. 9807 - 9816, View in Reaxys Mass Spectrometry (1) Description (Mass References Spectrometry) APCI (atmospher- Barker, Graeme; Webster, Stacey; Johnson, David G.; Curley, Rachel; Andrews, Matthew; Young, Paul ic pressure chem- C.; MacGregor, Stuart A.; Lee, Ai-Lan; Journal of Organic Chemistry; vol. 80; nb. 20; (2015); p. 9807 ical ionization); 9816, View in Reaxys spectrum

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Reaxys ID 23774103 View in Reaxys

3/6 CAS Registry Number: 14049-42-4 Linear Structure Formula: C7H4 (2)H2O2 Molecular Formula: C7H6O2 Molecular Weight: 124.108 InChI Key: FTNJQNQLEGKTGD-BFWBPSQCSA-N Note:

2H 2H

Substance Label (1) Label References 10

Velthuisen, Emile J.; Baughman, Todd M.; Johns, Brian A.; Temelkoff, David P.; Weatherhead, Jason G.; European Journal of Medicinal Chemistry; vol. 63; (2013); p. 202 - 212, View in Reaxys

Crystal Property Description (1) Colour & Other References Properties brown

Velthuisen, Emile J.; Baughman, Todd M.; Johns, Brian A.; Temelkoff, David P.; Weatherhead, Jason G.; European Journal of Medicinal Chemistry; vol. 63; (2013); p. 202 - 212, View in Reaxys

NMR Spectroscopy (1) 1 of 1

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]

400

Velthuisen, Emile J.; Baughman, Todd M.; Johns, Brian A.; Temelkoff, David P.; Weatherhead, Jason G.; European Journal of Medicinal Chemistry; vol. 63; (2013); p. 202 - 212, View in Reaxys

Reaxys ID 29576560 View in Reaxys

4/6 (2)H

Linear Structure Formula: C7H4 2O2 Molecular Formula: C7H6O2 Molecular Weight: 124.108 InChI Key: FTNJQNQLEGKTGD-QDNHWIQGSA-N Note:

O O

Substance Label (1) Label References 10

Pohjoispää, Monika; Mera-Adasme, Ral; Sundholm, Dage; Heikkinen, Sami; Hase, Tapio; Wähälä, Kristiina; Journal of Organic Chemistry; vol. 79; nb. 21; (2014); p. 10636 - 10640, View in Reaxys

NMR Spectroscopy (1) 1 of 1

Description (NMR Spec- Chemical shifts; Spectrum troscopy) Nucleus (NMR Spectroscopy)

13C

Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]

Location

supporting information

Pohjoispää, Monika; Mera-Adasme, Ral; Sundholm, Dage; Heikkinen, Sami; Hase, Tapio; Wähälä, Kristiina; Journal of Organic Chemistry; vol. 79; nb. 21; (2014); p. 10636 - 10640, View in Reaxys

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Reaxys ID 26969012 View in Reaxys

5/6 CAS Registry Number: 1419916-94-1 Chemical Name: 3,4-methylenedioxy-[13C6]-benzene Linear Structure Formula: C(13)C6H6O2 Molecular Formula: C7H6O2 Molecular Weight: 128.057 InChI Key: FTNJQNQLEGKTGD-ZFJHNFROSA-N Note:

O 13 C O

13C

13CH 13CH

Substance Label (1) Label References 10

Karlsen, Morten; Liu, Huiling; Berg, Thomas; Johansen, Jon Eigill; Hoff, Bard Helge; Journal of Labelled Compounds and Radiopharmaceuticals; vol. 57; nb. 5; (2014); p. 378 - 387, View in Reaxys

Patent-Specific Data (1) Location in Patent References Page/Page column

Patent; CHIRON A/S; Johansen, Jon Eigill; Liu, Huiling; Karlsen, Morten; US2014/227792; (2014); (A1) English, View in Reaxys

NMR Spectroscopy (2) 1 of 2

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

Coupling Nuclei

Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]

400

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

13C

Solvents (NMR Spectro- chloroform-d1 scopy) Frequency (NMR Spectroscopy) [MHz]

100

Karlsen, Morten; Liu, Huiling; Berg, Thomas; Johansen, Jon Eigill; Hoff, Bard Helge; Journal of Labelled Compounds and Radiopharmaceuticals; vol. 57; nb. 5; (2014); p. 378 - 387, View in Reaxys Mass Spectrometry (1) Description (Mass References Spectrometry) electron impact (EI); spectrum

Karlsen, Morten; Liu, Huiling; Berg, Thomas; Johansen, Jon Eigill; Hoff, Bard Helge; Journal of Labelled Compounds and Radiopharmaceuticals; vol. 57; nb. 5; (2014); p. 378 - 387, View in Reaxys

Reaxys ID 3848408 View in Reaxys

6/6 Chemical Name: benzo[1,3]dioxole; compound with picric acid; Benzo[1,3]dioxol; Verbindung mit Picrinsaeure Linear Structure Formula: C7H6O2*C6H3N3O7 Molecular Formula: C6H3N3O7*C7H6O2 Molecular Weight: 351.229 Type of Substance: heterocyclic InChI Key: AMGUXGFVJXIJFO-UHFFFAOYSA-N Note:

O O

N O

O O

N O

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Melting Point (1) 1 of 1

Melting Point [°C]

94 - 96

Solvent (Melting Point)

ethanol

Mosettig; Jovanovic; Monatshefte fuer Chemie; vol. 53/54; (1929); p. 435, View in Reaxys Crystal Property Description (1) Colour & Other References Properties rot

Mosettig; Jovanovic; Monatshefte fuer Chemie; vol. 53/54; (1929); p. 435, View in Reaxys

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