Reaxys
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Structure
Citations (36)
Structure/Compound Data Chemical Name: 2-(4-bromo-2,5-dimethoxyphenyl)-1-aminoethane Reaxys Registry Number: 4863873
CAS Registry Number: 66142-81-2 Type of Substance: isocyclic Molecular Formula: C10H14BrNO2
Linear Structure Formula: C10H14BrNO2
Molecular Weight: 260.131 InChI Key: YMHOBZXQZVXHBM-UHFFFAOYSA-N
1
N° of preparations All Preps | All Reactions 3 prep out of 40 reactions.
Available Data
N° of ref.
Identification Bioactivity (24)
31
Synthesize | Hide Details Find similar Chemical Names and Synonyms 2-(4-bromo-2,5-dimethoxyphenyl)-1-aminoethane, 2C-B, 2-(4-bromo-2,5-dimethoxyphenyl)ethanamine, 2-(4-bromo-2,5dimethoxyphenyl)ethylamine, 4-bromo-2,5-dimethoxyphenethylamine Identification Substance Label (9) Label
Reference
2C-B
Acuna-Castillo, Claudio; Villalobos, Claudio; Moya, Pablo R; Saez, Patricio; Cassels, Bruce K; Huidobro-Toro, J Pablo
British journal of pharmacology, 2002 , vol. 136, # 4 p. 510 - 519 Title/Abstract Full Text View citing articles Show Details
Villalobos, Claudio A.; Bull, Paulina; Saez, Patricio; Cassels, Bruce K.; Huidobro-Toro, J. Pablo
British Journal of Pharmacology, 2004 , vol. 141, # 7 p. 1167 - 1174 Title/Abstract Full Text View citing articles Show Details
Moya, Pablo R.; Berg, Kelly A.; Gutierrez-Hernandez, Manuel A.; Saez-Briones, Patricio; Reyes-Parada, Miguel; Cassels, Bruce K.; Clarke, William P.
Journal of Pharmacology and Experimental Therapeutics, 2007 , vol. 321, # 3 p. 1054 - 1061 Title/Abstract Full Text View citing articles Show Details
Xu, Ya-Zhu; Chen, Chinpiao
Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 13 p. 1187 - 1200 Title/Abstract Full Text View citing articles Show Details
Herth, Matthias M.; Leth-Petersen, Sebastian; Lehel, Szabolcs; Hansen, Martin; Knudsen, Gitte M.; Gillings, Nic; Madsen, Jacob; Kristensen, Jesper L.
RSC Advances, 2014 , vol. 4, # 41 p. 21347 - 21350 Title/Abstract Full Text View citing articles Show Details
Tirapegui, Cristian; Toro-Sazo, Miguel A.; Cassels, Bruce K.
Journal of the Chilean Chemical Society, 2014 , vol. 59, # 3 p. 2625 - 2627 Title/Abstract Full Text View citing articles Show Details
35
Lewin, Anita H.; Navarro, Hernan A.; Wayne Mascarella
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 15 p. 7415 - 7423 Title/Abstract Full Text View citing articles Show Details
1; 2C-B
McLean, Thomas H.; Parrish, Jason C.; Braden, Michael R.; Marona-Lewicka, Danuta; Gallardo-Godoy, Alejandra; Nichols, David E.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 19 p. 5794 - 5803 Title/Abstract Full Text View citing articles Show Details
2-CB
Locher, Christopher P.; Ruben, Peter C.; Gut, Jiri; Rosenthal, Philip J.
Antimicrobial Agents and Chemotherapy, 2003 , vol. 47, # 12 p. 3806 - 3809 Title/Abstract Full Text View citing articles Show Details
1b
Dowd; Herrick-Davis; Egan; DuPre; Smith; Teitler; Glennon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3074 - 3084 Title/Abstract Full Text View citing articles Show Details
2a, 2CB
Monte, Aaron P.; Marona-Lewicka, Danuta; Cozzi, Nicholas V.; Nelson, David L.; Nichols, David E.
Medicinal Chemistry Research, 1995 , vol. 5, # 9 p. 651 - 663 Title/Abstract Full Text Show Details
7
Glennon; Dukat; El-Bermawy; Law; De los Angeles; Teitler; King; Herrick-Davis
Journal of Medicinal Chemistry, 1994 , vol. 37, # 13 p. 1929 - 1935 Title/Abstract Full Text View citing articles Show Details
29
Glennon, Richard A.; Raghupathi, Reva; Bartyzel, Piotr; Teitler, Milt; Leonhardt, Sigrun
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 734 - 740 Title/Abstract Full Text View citing articles Show Details
11c
Cheng; Castagnoli Jr.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 513 - 520 Title/Abstract Full Text View citing articles Show Details
Bioactivity Pharmacological Data (17) 1 of 17
Comment (Pharmacological Data)
Bioactivities present
Reference
Glennon, Richard A.; Raghupathi, Reva; Bartyzel, Piotr; Teitler, Milt; Leonhardt, Sigrun
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 734 - 740 Title/Abstract Full Text View citing articles Show Details
Cheng; Castagnoli Jr.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 513 - 520 Title/Abstract Full Text View citing articles Show Details
Glennon; Dukat; El-Bermawy; Law; De los Angeles; Teitler; King; Herrick-Davis
Journal of Medicinal Chemistry, 1994 , vol. 37, # 13 p. 1929 - 1935 Title/Abstract Full Text View citing articles Show Details
Clare, Brian W.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 20 p. 3845 - 3856 Title/Abstract Full Text View citing articles Show Details
Monte, Aaron P.; Marona-Lewicka, Danuta; Cozzi, Nicholas V.; Nelson, David L.; Nichols, David E.
Medicinal Chemistry Research, 1995 , vol. 5, # 9 p. 651 - 663 Title/Abstract Full Text Show Details
Dowd; Herrick-Davis; Egan; DuPre; Smith; Teitler; Glennon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3074 - 3084 Title/Abstract Full Text View citing articles Show Details
Acuna-Castillo, Claudio; Villalobos, Claudio; Moya, Pablo R; Saez, Patricio; Cassels, Bruce K; Huidobro-Toro, J Pablo
British journal of pharmacology, 2002 , vol. 136, # 4 p. 510 - 519 Title/Abstract Full Text View citing articles Show Details
Altun, Ahmet; Golcuk, Kurtulus; Kumru, Mustafa; Jalbout, Abraham F.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 3861 - 3868 Title/Abstract Full Text View citing articles Show Details
Locher, Christopher P.; Ruben, Peter C.; Gut, Jiri; Rosenthal, Philip J.
Antimicrobial Agents and Chemotherapy, 2003 , vol. 47, # 12 p. 3806 - 3809 Title/Abstract Full Text View citing articles Show Details
Villalobos, Claudio A.; Bull, Paulina; Saez, Patricio; Cassels, Bruce K.; Huidobro-Toro, J. Pablo
British Journal of Pharmacology, 2004 , vol. 141, # 7 p. 1167 - 1174
Title/Abstract Full Text View citing articles Show Details
Thakur, Mamta; Thakur, Abhilash; Khadikar, Padmakar V.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 4 p. 825 - 831 Title/Abstract Full Text View citing articles Show Details
Theobald, Denis S.; Maurer, Hans H.
Biochemical Pharmacology, 2007 , vol. 73, # 2 p. 287 - 297 Title/Abstract Full Text View citing articles Show Details
McLean, Thomas H.; Parrish, Jason C.; Braden, Michael R.; Marona-Lewicka, Danuta; Gallardo-Godoy, Alejandra; Nichols, David E.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 19 p. 5794 - 5803 Title/Abstract Full Text View citing articles Show Details
Moya, Pablo R.; Berg, Kelly A.; Gutierrez-Hernandez, Manuel A.; Saez-Briones, Patricio; Reyes-Parada, Miguel; Cassels, Bruce K.; Clarke, William P.
Journal of Pharmacology and Experimental Therapeutics, 2007 , vol. 321, # 3 p. 1054 - 1061 Title/Abstract Full Text View citing articles Show Details
Montgomery; Buon; Eibauer; Guiry; Keenan; McBean
British Journal of Pharmacology, 2007 , vol. 152, # 7 p. 1121 - 1130 Title/Abstract Full Text View citing articles Show Details
Xu, Ya-Zhu; Chen, Chinpiao
Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 13 p. 1187 - 1200 Title/Abstract Full Text View citing articles Show Details
Lewin, Anita H.; Navarro, Hernan A.; Wayne Mascarella
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 15 p. 7415 - 7423 Title/Abstract Full Text View citing articles Show Details
Parrish, Jason C.; Braden, Michael R.; Gundy, Emily; Nichols, David E.
Journal of Neurochemistry, 2005 , vol. 95, # 6 p. 1575 - 1584 Title/Abstract Full Text View citing articles Show Details
Blaazer, Antoni R.; Smid, Pieter; Kruse, Chris G.
ChemMedChem, 2008 , vol. 3, # 9 p. 1299 - 1309 Title/Abstract Full Text View citing articles Show Details
Meyer, Markus R.; Maurer, Hans H.
Current Drug Metabolism, 2010 , vol. 11, # 5 p. 468 - 482 Title/Abstract Full Text View citing articles Show Details
2 of 17
Comment (Pharmacological Data)
Bioactivities present
Reference
Glennon; Raghupathi; Bartyzel; Teitler; Leonhardt
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 734 - 740 Title/Abstract Full Text Show Details
Johnson; Mathis; Shulgin; Hoffman; Nichols
Pharmacology, biochemistry, and behavior, 1990 , vol. 35, # 1 p. 211 - 217 Title/Abstract Full Text Show Details
McConnell; Bruce; Locher; Christopher P.
Patent: US5874477 , 1999 ; Title/Abstract Full Text Show Details
SATYA P. GUPTA; PRITHVI SINGH; MAHESH C. BINDAL
Chemical reviews, 1983 , vol. 83, # 6 p. 633 - 649 Title/Abstract Full Text Show Details
Herth, Matthias M.; Leth-Petersen, Sebastian; Lehel, Szabolcs; Hansen, Martin; Knudsen, Gitte M.; Gillings, Nic; Madsen, Jacob; Kristensen, Jesper L.
RSC Advances, 2014 , vol. 4, # 41 p. 21347 - 21350 Title/Abstract Full Text View citing articles Show Details
Tirapegui, Cristian; Toro-Sazo, Miguel A.; Cassels, Bruce K.
Journal of the Chilean Chemical Society, 2014 , vol. 59, # 3 p. 2625 - 2627 Title/Abstract Full Text View citing articles Show Details
Zhu, Binling; Meng, Liang; Zheng, Kefang
Forensic Science International, 2014 , vol. 242, p. e44 - e47 Title/Abstract Full Text View citing articles Show Details
Randox Laboratories Ltd.; Benchik, Elouard; Fitzgerald, Peter; Lowry, Philip; McConnell, Ivan
Patent: EP2950104 A1, 2015 ; Title/Abstract Full Text Show Details
Rojek, Sebastian; Bolechała, Filip; Kula, Karol; Maciów-Głąb, Martyna; Kłys, Małgorzata
Legal Medicine, 2016 , vol. 21, p. 64 - 72 Title/Abstract Full Text View citing articles Show Details
Vaiano, Fabio; Busardò, Francesco P.; Palumbo, Diego; Kyriakou, Chrystalla; Fioravanti, Alessia; Catalani, Valeria; Mari, Francesco; Bertol, Elisabetta
Journal of Pharmaceutical and Biomedical Analysis, 2016 , vol. 129, p. 441 - 449 Title/Abstract Full Text View citing articles Show Details
Glicksberg, Lindsay; Bryand, Kelsie; Kerrigan, Sarah
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2016 , vol. 1035, p. 91 - 103 Title/Abstract Full Text Show Details
3 of 17
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
Randox Laboratories Ltd.; Benchik, Elouard; Fitzgerald, Peter; Lowry, Philip; McConnell, Ivan
Patent: EP2950104 A1, 2015 ; Title/Abstract Full Text Show Details
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Effect (Pharmacological Data)
agonist
Species or TestSystem (Pharmacological Data)
RD-HGA16 cells expressing human TAAR 1 receptor
Method (Pharmacological Data)
hTAAR1 activation assay; title comp. incubated with test cells in presence of Calcium 3 dye as fluorescent substrate (HAM's F-12 medium, 10percent FBS, 5percent CO2/95percent air, 37 deg C, 1 h); title comp. effect on internal calcium mobilization assessed; fluorimetry
Further Details (Pharmacological Data)
hTAAR1: human trace amine receptor 1; Emax: maximal title comp. efficacy
Type (Pharmacological Data)
EC50
Value of Type (Pharmacological Data)
7190 nmol/l
Results
title comp. exhibited Emax 22percent
Reference
Lewin, Anita H.; Navarro, Hernan A.; Wayne Mascarella
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 15 p. 7415 - 7423 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
behavioural symptoms
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
8.4 μmol/kg
Method (Pharmacological Data)
immediately after title comp. injection rats placed in dark Plexiglas box and number of head shakes was quantified for 25 min, starting 5 min after title comp. administration
Further Details (Pharmacological Data)
control: saline; 5-HT: serotonin
Comment (Pharmacological Data)
No effect
Reference
Moya, Pablo R.; Berg, Kelly A.; Gutierrez-Hernandez, Manuel A.; Saez-Briones, Patricio; Reyes-Parada, Miguel; Cassels, Bruce K.; Clarke, William P.
Journal of Pharmacology and Experimental Therapeutics, 2007 , vol. 321, # 3 p. 1054 - 1061 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
partial agonist
Species or TestSystem (Pharmacological Data)
CHO-1C19 cells expressing human 5-HT2A receptors
Method (Pharmacological Data)
cells in serum-free medium labeled with 1 μCi/ml myo-<3H>inositol 24 h and with 0.1 μCi/ml <3H>AA 4 h at 37 deg C; then treated 10 min with title comp.; dose-response curve for total IP accumulation and AA release calculated
Further Details (Pharmacological Data)
control: vehicle; AA: arachidonic acid; IP: inositol phosphate; CHO: Chinese hamster ovary; data expressed as percent of maximal response to 5-HT; 5-HT: serotonin; PLA2 and PLC: phospholipase A2 and phospholipase C, resp.; RE: relative efficacy
Results
title comp. behaved as very weak partial agonist for both PLC-mediated IP (RE = ca. 10percent) and PLA2-mediated AA (RE = ca. 5percent) responses (figures, table)
Reference
Moya, Pablo R.; Berg, Kelly A.; Gutierrez-Hernandez, Manuel A.; Saez-Briones, Patricio; Reyes-Parada, Miguel; Cassels, Bruce K.; Clarke, William P.
Journal of Pharmacology and Experimental Therapeutics, 2007 , vol. 321, # 3 p. 1054 - 1061 Title/Abstract Full Text View citing articles Show Details
7 of 17
8 of 17
9 of 17
Effect (Pharmacological Data)
agonist
Species or TestSystem (Pharmacological Data)
CHO-1C19 cells expressing human 5-HT2C receptors
Method (Pharmacological Data)
cells in serum-free medium labeled with 1 μCi/ml myo-<3H>inositol 24 h and with 0.1 μCi/ml <3H>AA 4 h at 37 deg C; then treated 10 min with title comp.; dose-response curve for total IP accumulation and AA release calculated
Further Details (Pharmacological Data)
control: vehicle; AA: arachidonic acid; IP: inositol phosphate; CHO: Chinese hamster ovary; data expressed as percent of maximal response to 5-HT; 5-HT: serotonin; PLA2 and PLC: phospholipase A2 and phospholipase C, resp.; RE: relative efficacy
Results
title comp. preferentially stimulated PLA2-mediated AA release (RE = ca. 50percent and pEC50 = 6.80); RE for PLC-mediated IP accumulation was ca. 40percent, pEC50 = 6.52 (figures, table)
Reference
Moya, Pablo R.; Berg, Kelly A.; Gutierrez-Hernandez, Manuel A.; Saez-Briones, Patricio; Reyes-Parada, Miguel; Cassels, Bruce K.; Clarke, William P.
Journal of Pharmacology and Experimental Therapeutics, 2007 , vol. 321, # 3 p. 1054 - 1061 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
agonist
Species or TestSystem (Pharmacological Data)
NIH3T3 cells expressing rat 5-HT2A receptors
Method (Pharmacological Data)
inositol phosphates (IP3) accumulation assayed; cells labeled for 18-20 h with <3H>-myo-inositol; incubated with title comp. at 37 deg C for 30 min in 5 percent CO2 atmosphere; <3H>IP3 separated, quantified by scintillation counting
Further Details (Pharmacological Data)
IA (intrinsic activity): percent maximal stimulation relative to 10 μmol/l 5-HT
Type (Pharmacological Data)
EC50
Value of Type (Pharmacological Data)
27 nmol/l
Results
IA: 82 percent
Reference
McLean, Thomas H.; Parrish, Jason C.; Braden, Michael R.; Marona-Lewicka, Danuta; Gallardo-Godoy, Alejandra; Nichols, David E.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 19 p. 5794 - 5803 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
receptor; binding activity
Species or TestSystem (Pharmacological Data)
NIH3T3 cells expressing human 5-HT2A receptors
Method (Pharmacological Data)
competition binding assay; <125I>DOI (0.20 nmol/l) used as radioligand; Tris buffer, pH 7.4; 25 deg C; 60 min incubation; scintillation counting
Type (Pharmacological Data)
Ki
Value of Type (Pharmacological Data)
0.88 nmol/l
Reference
McLean, Thomas H.; Parrish, Jason C.; Braden, Michael R.; Marona-Lewicka, Danuta; Gallardo-Godoy, Alejandra; Nichols, David E.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 19 p. 5794 - 5803 Title/Abstract Full Text View citing articles Show Details
10 of 17
11 of 17
12 of 17
13 of 17
Effect (Pharmacological Data)
receptor; binding activity
Species or TestSystem (Pharmacological Data)
NIH3T3 cells expressing rat 5-HT2A receptors
Method (Pharmacological Data)
competition binding assay; <125I>DOI (0.20 nmol/l) used as radioligand; Tris buffer, pH 7.4; 25 deg C; 60 min incubation; scintillation counting
Type (Pharmacological Data)
Ki
Value of Type (Pharmacological Data)
0.66 nmol/l
Reference
McLean, Thomas H.; Parrish, Jason C.; Braden, Michael R.; Marona-Lewicka, Danuta; Gallardo-Godoy, Alejandra; Nichols, David E.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 19 p. 5794 - 5803 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
receptor; binding activity
Species or TestSystem (Pharmacological Data)
rat cortex synaptosomal membrane-enriched fraction
Method (Pharmacological Data)
the ability of title comp. to bind to serotonin receptors determined by measuring cAMP induced by serotonin; samples incubated for 2 min at room temp. in the presence of isobutyl methylxanthine; incubation with iodinated tracer; gamma spectrometry
Type (Pharmacological Data)
Kd
Value of Type (Pharmacological Data)
90.0 nmol/l
Reference
Locher, Christopher P.; Ruben, Peter C.; Gut, Jiri; Rosenthal, Philip J.
Antimicrobial Agents and Chemotherapy, 2003 , vol. 47, # 12 p. 3806 - 3809 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
antimalarial
Species or TestSystem (Pharmacological Data)
Plasmodium falciparum
Method (Pharmacological Data)
parasites in the schizont stage (0.1 percent parasitemia, 1 percent hematocrit) incubated with title comp. and <3H>hypoxanthine for 72 h; <3H>hypoxanthine incorporation determined
Further Details (Pharmacological Data)
P. falciparum: Falciparum Uganda Palo Alto (FUP, mefloquine resistant) strain
Type (Pharmacological Data)
IC50
Value of Type (Pharmacological Data)
1.52 μmol/l
Results
title comp. in dose-dependent manner inhibited plasmodium growth
Reference
Locher, Christopher P.; Ruben, Peter C.; Gut, Jiri; Rosenthal, Philip J.
Antimicrobial Agents and Chemotherapy, 2003 , vol. 47, # 12 p. 3806 - 3809 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
receptor; binding activity
Species or Test-
NIH-3T3 cell membranes expressing rat 5-HT2A receptors
System (Pharmacological Data)
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Kind of Dosing (Pharmacological Data)
as hydrochloride
Method (Pharmacological Data)
in vitro; radioligand competition binding assay; 0.5 nmol/l <3H>ketanserin used as radioligand; binding buffer, pH 7.4; 37 deg C; incubated for 30 min; liquid scintillation counting; nonspecific binding determined using 10 μmol/l ketanserin
Type (Pharmacological Data)
Ki
Value of Type (Pharmacological Data)
16 nmol/l
Reference
Dowd; Herrick-Davis; Egan; DuPre; Smith; Teitler; Glennon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3074 - 3084 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
receptor; binding activity
Species or TestSystem (Pharmacological Data)
A-9 cell membranes expressing rat 5-HT2C receptors
Kind of Dosing (Pharmacological Data)
as hydrochloride salt
Method (Pharmacological Data)
in vitro; radioligand competition binding assay; 2.0 nmol/l <3H>mesulegrine used as radioligand; binding buffer, pH 7.4; 37 deg C; incubated for 30 min; liquid scintillation counting; nonspecific binding determined using 1 μmol/l mesulegrine
Type (Pharmacological Data)
Ki
Value of Type (Pharmacological Data)
190 nmol/l
Reference
Dowd; Herrick-Davis; Egan; DuPre; Smith; Teitler; Glennon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3074 - 3084 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
behavioural symptoms
Species or TestSystem (Pharmacological Data)
rat
Method (Pharmacological Data)
in vivo; two-lever drug discrimination test in rats trained to discriminate LSD from saline; 4 - 6 dose levels; 8 - 12 rats tested at each dose
Type (Pharmacological Data)
ED50
Value of Type (Pharmacological Data)
1.13 μmol/kg
Results
test compd fully substituted LSD
Reference
Monte, Aaron P.; Marona-Lewicka, Danuta; Cozzi, Nicholas V.; Nelson, David L.; Nichols, David E.
Medicinal Chemistry Research, 1995 , vol. 5, # 9 p. 651 - 663 Title/Abstract Full Text Show Details
Comment (Pharmacological Data)
affinity and selectivity in 5-HT2A and 5-HT2C serotonin receptor binding
Reference
Glennon; Dukat; El-Bermawy; Law; De los Angeles; Teitler; King; Herrick-Davis
Journal of Medicinal Chemistry, 1994 , vol. 37, # 13 p. 1929 - 1935 Title/Abstract Full Text View citing articles Show Details
17 of 17
Comment (Pharmacological Data)
binding affinity at 5-HT1C and 5HT2 serotonin receptors; lack of selectivity
Reference
Glennon, Richard A.; Raghupathi, Reva; Bartyzel, Piotr; Teitler, Milt; Leonhardt, Sigrun
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 734 - 740 Title/Abstract Full Text View citing articles Show Details
Ecotoxicology (7) 1 of 7
2 of 7
3 of 7
Effect (Ecotoxicology)
antagonist
Species or TestSystem (Ecotoxicology)
Xenopus laevis oocyte
Concentration (Ecotoxicology)
10 - 30 nmol/l
Kind of Dosing (Ecotoxicology)
used as hydrobromide salt; dissolved in Barth's solution
Method (Ecotoxicology)
cultured cells expressing rat 5-HT2A receptors voltage-clamped at membrane potential of -70 mV; cells superfused with title comp. preapplied for 2 min prior to challenge with increasing concentrations of 5-HT; changes in 5-HT-evoked currents recorded
Further Details (Ecotoxicology)
5-HT: 5-hydroxytryptamine
Results
title comp. antagonized 5-HT2A receptors; it concentration-dependently blocked 5-HT-evoked currents (figure)
Reference
Villalobos, Claudio A.; Bull, Paulina; Saez, Patricio; Cassels, Bruce K.; Huidobro-Toro, J. Pablo
British Journal of Pharmacology, 2004 , vol. 141, # 7 p. 1167 - 1174 Title/Abstract Full Text View citing articles Show Details
Effect (Ecotoxicology)
antagonist
Species or TestSystem (Ecotoxicology)
Xenopus laevis oocyte
Concentration (Ecotoxicology)
Ca. 1E-11 - 1E-07 mol/l
Kind of Dosing (Ecotoxicology)
used as hydrobromide salt; dissolved in Barth's solution
Method (Ecotoxicology)
cultured cells expressing rat 5-HT2A receptors voltage-clamped at membrane potential of -70 mV; cells superfused with title comp. preapplied for 2 min prior to challenge with 100 nmol/l of 5-HT; 5-HT-evoked currents recorded
Further Details (Ecotoxicology)
5-HT: 5-hydroxytryptamine
Type (Ecotoxicology)
pIC50
Value of Type (Ecotoxicology)
8.28 dimensionless
Results
title comp. behaved as 5-HT2A receptor antagonist; it reversibly and concentration-dependently blocked 5-HT-evoked currents (figure, table)
Reference
Villalobos, Claudio A.; Bull, Paulina; Saez, Patricio; Cassels, Bruce K.; Huidobro-Toro, J. Pablo
British Journal of Pharmacology, 2004 , vol. 141, # 7 p. 1167 - 1174 Title/Abstract Full Text View citing articles Show Details
Effect (Ecotoxicology)
antagonist
Species or TestSystem (Ecotoxicology)
Xenopus laevis oocyte
Concentration (Ecotoxicology)
10 nmol/l
Kind of Dosing (Ecotoxicology)
used as hydrobromide salt; dissolved in Barth's solution
Method (Ecotoxicology)
cultured cells expressing rat 5-HT2A receptors voltage-clamped at membrane potential of -70 mV; cells superfused with title comp. preapplied for 1 - 3 min prior to challenge with 100 nmol/l of 5-HT; changes in 5-HT-evoked currents recorded
Further Details (Ecotoxicology)
5-HT: 5-hydroxytryptamine
Results
title comp. antagonized 5-HT2A receptors; it time-dependently blocked 5-HT-evoked currents (figure)
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Reference
Villalobos, Claudio A.; Bull, Paulina; Saez, Patricio; Cassels, Bruce K.; Huidobro-Toro, J. Pablo
British Journal of Pharmacology, 2004 , vol. 141, # 7 p. 1167 - 1174 Title/Abstract Full Text View citing articles Show Details
Effect (Ecotoxicology)
membrane currents; inhibition of
Species or TestSystem (Ecotoxicology)
Xenopus laevis oocyte
Concentration (Ecotoxicology)
10 nmol/l
Kind of Dosing (Ecotoxicology)
used as hydrobromide salt; dissolved in Barth's solution
Method (Ecotoxicology)
cultured cells expressing rat 5-HT2A receptors voltage-clamped at membrane potential of -70 mV; cells superfused with title comp. preapplied for 2 min prior to challenge with increasing concentrations of 5-HT; changes in 5-HT-evoked currents recorded
Further Details (Ecotoxicology)
5-HT: 5-hydroxytryptamine
Results
title comp. antagonized 5-HT2A receptors; it blocked 5-HT-evoked currents (figure)
Reference
Villalobos, Claudio A.; Bull, Paulina; Saez, Patricio; Cassels, Bruce K.; Huidobro-Toro, J. Pablo
British Journal of Pharmacology, 2004 , vol. 141, # 7 p. 1167 - 1174 Title/Abstract Full Text View citing articles Show Details
Effect (Ecotoxicology)
membrane currents; inhibition of
Species or TestSystem (Ecotoxicology)
Xenopus laevis oocyte
Concentration (Ecotoxicology)
10 nmol/l
Kind of Dosing (Ecotoxicology)
used as hydrobromide salt; dissolved in Barth's solution
Method (Ecotoxicology)
cultured cells expressing rat 5-HT2C receptors voltage-clamped at membrane potential of -70 mV; cells superfused with title comp. preapplied for 2 min prior to challenge with increasing concentrations of 5-HT; changes in 5-HT-evoked currents recorded
Further Details (Ecotoxicology)
5-HT: 5-hydroxytryptamine
Comment (Ecotoxicology)
No effect
Reference
Villalobos, Claudio A.; Bull, Paulina; Saez, Patricio; Cassels, Bruce K.; Huidobro-Toro, J. Pablo
British Journal of Pharmacology, 2004 , vol. 141, # 7 p. 1167 - 1174 Title/Abstract Full Text View citing articles Show Details
Effect (Ecotoxicology)
membrane current; induction of
Species or TestSystem (Ecotoxicology)
Xenopus laevis oocyte
Kind of Dosing (Ecotoxicology)
used as hydrobromide; 6 - 7 concentrations were applied
Method (Ecotoxicology)
oocytes expressing rat 5-HT2A receptors; two-electrode voltage clamp at -70 mV; standard medium at 15 deg C; addition of increasing concentrations of title comp. for 10 s; stimulation of membrane currents was determined
Further Details (Ecotoxicology)
5-HT: serotonin
Type (Ecotoxicology)
EC50
Value of Type (Ecotoxicology)
689 nmol/l
Results
title comp. concentration-dependently induced membrane current (table)
Reference
Acuna-Castillo, Claudio; Villalobos, Claudio; Moya, Pablo R; Saez, Patricio; Cassels, Bruce K; Huidobro-Toro, J Pablo
British journal of pharmacology, 2002 , vol. 136, # 4 p. 510 - 519 Title/Abstract Full Text View citing articles Show Details
Effect (Ecotoxicology)
membrane current; induction of
Species or Test-
Xenopus laevis oocyte
System (Ecotoxicology) Kind of Dosing (Ecotoxicology)
used as hydrobromide; 6 - 7 concentrations were applied
Method (Ecotoxicology)
oocytes expressing rat 5-HT2C receptors; two-electrode voltage clamp at -70 mV; standard medium at 15 deg C; addition of increasing concentrations of title comp. for 10 s; stimulation of membrane currents was determined
Further Details (Ecotoxicology)
5-HT: serotonin; Imax: maximal current relative to that evoked by 5-HT
Type (Ecotoxicology)
EC50
Value of Type (Ecotoxicology)
493 nmol/l
Results
title comp. concentration-dependently induced membrane current with Imax = 50 percent (table)
Reference
Acuna-Castillo, Claudio; Villalobos, Claudio; Moya, Pablo R; Saez, Patricio; Cassels, Bruce K; Huidobro-Toro, J Pablo
British journal of pharmacology, 2002 , vol. 136, # 4 p. 510 - 519 Title/Abstract Full Text View citing articles Show Details
Chemical Name: 4-bromo-2,5-dimethoxy-β-phenethylamine hydrochloride
2
Reaxys Registry Number: 10713423
Type of Substance: isocyclic Molecular Formula: C10H14BrNO2*ClH Linear Structure Formula: C10H14BrNO2*HCl Molecular Weight: 296.592 InChI Key: UJTWHDAMHSIRDK-UHFFFAOYSA-N
0 prep out of 43 reactions.
Identification Physical Data (2) Spectra (2) Bioactivity (5)
Synthesize | Hide Details Find similar Chemical Names and Synonyms 4-bromo-2,5-dimethoxy-β-phenethylamine hydrochloride, 2-(4-bromo-2,5-dimethoxyphenyl)ethanamine hydrochloride, 2,5-dimethoxy-4bromophenylethylamine hydrochloride, 4-bromo-2,5-dimethoxyphenethylamine hydrochloride Identification Substance Label (4) Label
Reference
2C-B HCl
Hansen, Martin; Jacobsen, Stine Engesgaard; Plunkett, Shane; Liebscher, Gudrun Eckhard; McCorvy, John D.; Bräuner-Osborne, Hans; Kristensen, Jesper Langgaard
Bioorganic and Medicinal Chemistry, 2015 , vol. 23, # 14 p. 3933 - 3937 Title/Abstract Full Text View citing articles Show Details
2C-B; BDMPEA
Rohanova, Miroslava; Palenicek, Tomas; Balikova, Marie
Toxicology Letters, 2008 , vol. 178, # 1 p. 29 - 36 Title/Abstract Full Text View citing articles Show Details
2C-B
Theobald, Denis S.; Maurer, Hans H.
Biochemical Pharmacology, 2007 , vol. 73, # 2 p. 287 - 297 Title/Abstract Full Text View citing articles Show Details
2CB
Montgomery; Buon; Eibauer; Guiry; Keenan; McBean
British Journal of Pharmacology, 2007 , vol. 152, # 7 p. 1121 - 1130 Title/Abstract Full Text View citing articles Show Details
Physical Data Melting Point (1) Melting Point
Reference
237 - 239 °C
Montgomery; Buon; Eibauer; Guiry; Keenan; McBean
British Journal of Pharmacology, 2007 , vol. 152, # 7 p. 1121 - 1130 Title/Abstract Full Text View citing articles Show Details
5
Crystal Property Description (1) Colour & Other Properties
Reference
light-brown - yellow
Montgomery; Buon; Eibauer; Guiry; Keenan; McBean
British Journal of Pharmacology, 2007 , vol. 152, # 7 p. 1121 - 1130 Title/Abstract Full Text View citing articles Show Details
Spectra NMR Spectroscopy (1) Description (NMR Spectroscopy)
Nucleus (NMR Spectroscopy)
Solvents (NMR Spectroscopy)
Frequency (NMR Spectroscopy)
Chemical shifts
1H
dimethylsulfoxide-d6
300 MHz
Reference Montgomery; Buon; Eibauer; Guiry; Keenan; McBean
British Journal of Pharmacology, 2007 , vol. 152, # 7 p. 1121 - 1130 Title/Abstract Full Text View citing articles Show Details
IR Spectroscopy (1) Description (IR Spectroscopy)
Solvent (IR Spectroscopy)
Reference
Bands
KBr
Montgomery; Buon; Eibauer; Guiry; Keenan; McBean
British Journal of Pharmacology, 2007 , vol. 152, # 7 p. 1121 - 1130 Title/Abstract Full Text View citing articles Show Details
Bioactivity Pharmacological Data (5) 1 of 5
2 of 5
Comment (Pharmacological Data)
Bioactivities present
Reference
Theobald, Denis S.; Maurer, Hans H.
Biochemical Pharmacology, 2007 , vol. 73, # 2 p. 287 - 297 Title/Abstract Full Text View citing articles Show Details
Montgomery; Buon; Eibauer; Guiry; Keenan; McBean
British Journal of Pharmacology, 2007 , vol. 152, # 7 p. 1121 - 1130 Title/Abstract Full Text View citing articles Show Details
Rohanova, Miroslava; Palenicek, Tomas; Balikova, Marie
Toxicology Letters, 2008 , vol. 178, # 1 p. 29 - 36 Title/Abstract Full Text View citing articles Show Details
Hansen, Martin; Phonekeo, Karina; Paine, James S.; Leth-Petersen, Sebastian; Begtrup, Mikael; Braeuner-Osborne, Hans; Kristensen, Jesper L.
ACS Chemical Neuroscience, 2014 , vol. 5, # 3 p. 243 - 249 Title/Abstract Full Text View citing articles Show Details
Hansen, Martin; Jacobsen, Stine Engesgaard; Plunkett, Shane; Liebscher, Gudrun Eckhard; McCorvy, John D.; BräunerOsborne, Hans; Kristensen, Jesper Langgaard
Bioorganic and Medicinal Chemistry, 2015 , vol. 23, # 14 p. 3933 - 3937 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
pharmacokinetics
Species or TestSystem (Pharmacological Data)
Wistar rat
Sex
male
Route of Application
subcutaneous
Concentration (Pharmacological Data)
50 mg/kg
Kind of Dosing (Pharmacological Data)
title comp. dissolved in physiological saline
3 of 5
4 of 5
Method (Pharmacological Data)
blood, lung, liver, and brain assessed for title comp. and metabolites conc. for up to 360 min postdosing using GC-MS
Further Details (Pharmacological Data)
GC-MS: gas chromatography mass spectrometry; metabolites of title comp. analyzed: 2M5H-BPEA (4-bromo-2-methoxy-5hydroxyphenethylamine), and 2H5M-BPEA (4-bromo-2-hydroxy-5-methoxyphenethylamine)
Results
title comp. peaked in serum 30 min and in other tissues 1 h postdosing, moreover conc. in organs, especially lung and brain was much higher than in blood (table); 2H5M-BPEA reached high conc. only in tissues (liver, lung - 1 h, brain - 2 h postdosing)
Metabolite (Pharmacological Data)
4-bromo-2-hydroxy-5-methoxyphenethylamine [Reaxys RN: 15852011]
Reference
Rohanova, Miroslava; Palenicek, Tomas; Balikova, Marie
Toxicology Letters, 2008 , vol. 178, # 1 p. 29 - 36 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transport; inhibition of
Species or TestSystem (Pharmacological Data)
rat phaeochromocytoma PC12 cells
Concentration (Pharmacological Data)
1E-08 - 0.0005 mol/l
Method (Pharmacological Data)
cells expressed NET, at 80percent confluency; incubation with 10 μmol/l <3H>noradrenaline and title comp. in HEPES buffer for 5 min at 37 deg C; radioactivity incorporated in cells was determined by liquid scintillation spectroscopy
Further Details (Pharmacological Data)
nonspecific <3H>noradrenaline uptake was determined in presence of nisoxetine; reference comp.: 3,4-methylenedioxymethamphetamine (inhibition conc. 50 = 6.6 μmol/l); NET: noradrenaline transporter
Type (Pharmacological Data)
IC50
Value of Type (Pharmacological Data)
312.9 μmol/l
Results
title comp. inhibited NET-mediated <3H>noradrenaline uptake in competitive manner; fig.
Reference
Montgomery; Buon; Eibauer; Guiry; Keenan; McBean
British Journal of Pharmacology, 2007 , vol. 152, # 7 p. 1121 - 1130 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transport; inhibition of
Species or TestSystem (Pharmacological Data)
rat phaeochromocytoma PC12 cells
Concentration (Pharmacological Data)
1E-08 - 0.0005 mol/l
Method (Pharmacological Data)
cells expressed NET, at 80percent confluency; incubation with 10 μmol/l <3H>noradrenaline and title comp. in HEPES buffer for 5 min at 37 deg C; radioactivity incorporated in cells was determined by liquid scintillation spectroscopy
Further Details (Pharmacological Data)
nonspecific <3H>noradrenaline uptake was determined in presence of nisoxetine; reference comp.: 3,4-methylenedioxymethamphetamine (Ki = 0.6 μmol/l); NET: noradrenaline transporter
Type (Pharmacological Data)
Ki
Value of Type (Pharmacological Data)
27.4 μmol/l
Results
title comp. inhibited NET-mediated <3H>noradrenaline uptake in competitive manner; fig.
Reference
Montgomery; Buon; Eibauer; Guiry; Keenan; McBean
British Journal of Pharmacology, 2007 , vol. 152, # 7 p. 1121 - 1130 Title/Abstract Full Text View citing articles Show Details
5 of 5
Effect (Pharmacological Data) Species or TestSystem (Pharmacological Data)
transport; inhibition of
T-REx SERT HEK293 cells
Concentration (Pharmacological Data)
1E-08 - 0.0005 mol/l
Method (Pharmacological Data)
cells at 80percent confluency; incubation with 10 μmol/l <3H>5-hydroxytryptamine and title comp. for 6 min at 37 deg C; radioactivity incorporated in cells was determined by liquid scintillation spectroscopy
Further Details (Pharmacological Data)
nonspecific <3H>5-hydroxytryptamine uptake was determined in presence of paroxetine; reference comp.: 3,4methylenedioxymethamphetamine (inhibition conc. 50 = 34.8 μmol/l); SERT: 5-hydroxytryptamine transporter
Type (Pharmacological Data)
IC50
Value of Type (Pharmacological Data)
67.1 μmol/l
Results
title comp. inhibited SERT-mediated <3H>5-hydroxytryptamine uptake in non-competitive manner; fig.
Reference
Montgomery; Buon; Eibauer; Guiry; Keenan; McBean
British Journal of Pharmacology, 2007 , vol. 152, # 7 p. 1121 - 1130 Title/Abstract Full Text View citing articles Show Details
Chemical Name: Nexus hydrobromide Reaxys Registry Number: 7055162
Type of Substance: isocyclic Molecular Formula: BrH*C10H14BrNO2
Linear Structure Formula: C10H14BrNO2*HBr Molecular Weight: 341.043 InChI Key: WGWOFNYIBCKZMV-UHFFFAOYSA-N
1 prep out of 1 reactions.
3
Synthesize | Hide Details Find similar Chemical Names and Synonyms Nexus hydrobromide, 2-(4-bromo-2,5-dimethoxyphenyl)-1-aminoethane hydrobromide, 2,5-dimethoxy-4-bromophenylethylamine hydrobromide Identification Substance Label (1) Label
Reference
7*HBr
Glennon; Dukat; El-Bermawy; Law; De los Angeles; Teitler; King; Herrick-Davis
Journal of Medicinal Chemistry, 1994 , vol. 37, # 13 p. 1929 - 1935 Title/Abstract Full Text View citing articles Show Details
Derivative (1) Derivative
Reference
4-bromo-2,5-dimethoxy-β-phenethylamine hydrochloride
Montgomery; Buon; Eibauer; Guiry; Keenan; McBean
British Journal of Pharmacology, 2007 , vol. 152, # 7 p. 1121 - 1130 Title/Abstract Full Text View citing articles Show Details
Physical Data Melting Point (1)
Identification Physical Data (1) Bioactivity (1)
3
Melting Point
Reference
198 - 201 °C
Glennon; Dukat; El-Bermawy; Law; De los Angeles; Teitler; King; Herrick-Davis
Journal of Medicinal Chemistry, 1994 , vol. 37, # 13 p. 1929 - 1935 Title/Abstract Full Text View citing articles Show Details
Bioactivity Pharmacological Data (1) 1 of 1
Comment (Pharmacological Data)
Bioactivities present
Reference
Glennon; Dukat; El-Bermawy; Law; De los Angeles; Teitler; King; Herrick-Davis
Journal of Medicinal Chemistry, 1994 , vol. 37, # 13 p. 1929 - 1935 Title/Abstract Full Text View citing articles Show Details
Montgomery; Buon; Eibauer; Guiry; Keenan; McBean
British Journal of Pharmacology, 2007 , vol. 152, # 7 p. 1121 - 1130 Title/Abstract Full Text View citing articles Show Details
Lobos; Borges; Gonzalez; Cassels
General Pharmacology, 1992 , vol. 23, # 6 p. 1139 - 1142 Title/Abstract Full Text Show Details
Chemical Name: 2-(4-bromo-2,5-di([2H3]methoxy)phenyl)ethylamine
1 prep out of 1 reactions.
Identification Spectra (5)
1
Reaxys Registry Number: 11306108
Molecular Formula: C10H14BrNO2
Linear Structure Formula: C10H8(2)H6BrNO2
4
Molecular Weight: 266.083 InChI Key: YMHOBZXQZVXHBM-WFGJKAKNSA-N
Synthesize | Hide Details Find similar Chemical Names and Synonyms 2-(4-bromo-2,5-di([2H3]methoxy)phenyl)ethylamine Identification Substance Label (1) Label
Reference
6; <2H&6%>-2C-B
Xu, Ya-Zhu; Chen, Chinpiao
Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 13 p. 1187 - 1200 Title/Abstract Full Text View citing articles Show Details
Spectra NMR Spectroscopy (3) Description (NMR Spectroscopy)
Nucleus (NMR Spectroscopy)
Coupling Nuclei
Solvents (NMR Spectroscopy)
Frequency (NMR Spectroscopy)
Chemical shifts
1H
CDCl3
300 MHz
Xu, Ya-Zhu; Chen, Chinpiao
Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 13 p. 1187 - 1200 Title/Abstract Full Text View citing articles Show Details
1H
1H
CDCl3
300 MHz
Xu, Ya-Zhu; Chen, Chinpiao
Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 13 p. 1187 - 1200 Title/Abstract Full Text View citing articles Show Details
Chemical shifts
13C
CDCl3
75.5 MHz
Xu, Ya-Zhu; Chen, Chinpiao
Reference
Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 13 p. 1187 - 1200 Title/Abstract Full Text View citing articles Show Details
IR Spectroscopy (1) Description (IR Spectroscopy)
Solvent (IR Spectroscopy)
Reference
Bands
film
Xu, Ya-Zhu; Chen, Chinpiao
Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 13 p. 1187 - 1200 Title/Abstract Full Text View citing articles Show Details
Mass Spectrometry (1) Description (Mass Spectrometry)
Reference
spectrum electron impact (EI)
Xu, Ya-Zhu; Chen, Chinpiao
Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 13 p. 1187 - 1200 Title/Abstract Full Text View citing articles Show Details
Chemical Name: Nexus tartrate
no reactions.
Bioactivity (1)
1
8 prep out of 8 reactions.
Identification Physical Data (1) Spectra (3)
1
Reaxys Registry Number: 24419958
Molecular Formula: C4H6O6*C10H14BrNO2
Linear Structure Formula: C4H6O6*C10H14BrNO2
Molecular Weight: 410.219 5
Synthesize | Hide Details Find similar Chemical Names and Synonyms Nexus tartrate Bioactivity Pharmacological Data (1) 1 of 1
Comment (Pharmacological Data)
Bioactivities present
Reference
Theobald, Denis S.; Maurer, Hans H.
Biochemical Pharmacology, 2007 , vol. 73, # 2 p. 287 - 297 Title/Abstract Full Text View citing articles Show Details
Chemical Name: 4-bromo-2,5-dimethoxy-[13C6]-phenethylamine hydrochloride Reaxys Registry Number: 26969026
Molecular Formula: C10H14BrNO2*ClH Linear Structure Formula: C4(13)C6H14BrNO2*ClH
6
Molecular Weight: 302.526 InChI Key: UJTWHDAMHSIRDK-QJPVZZEOSA-N
Synthesize | Hide Details Find similar
Chemical Names and Synonyms 4-bromo-2,5-dimethoxy-[13C6]-phenethylamine hydrochloride Identification Substance Label (1) Label
Reference
5a
Karlsen, Morten; Liu, Huiling; Berg, Thomas; Johansen, Jon Eigill; Hoff, Bard Helge
Journal of Labelled Compounds and Radiopharmaceuticals, 2014 , vol. 57, # 5 p. 378 - 387 Title/Abstract Full Text View citing articles Show Details
Physical Data Melting Point (1) Melting Point
Comment (Melting Point)
Reference
224 - 225 °C
with decomposition
Karlsen, Morten; Liu, Huiling; Berg, Thomas; Johansen, Jon Eigill; Hoff, Bard Helge
Journal of Labelled Compounds and Radiopharmaceuticals, 2014 , vol. 57, # 5 p. 378 - 387 Title/Abstract Full Text View citing articles Show Details
Spectra NMR Spectroscopy (2) Description (NMR Spectroscopy)
Nucleus (NMR Spectroscopy)
Coupling Nuclei
Solvents (NMR Spectroscopy)
Frequency (NMR Spectroscopy)
Chemical shifts
1H
1H
dimethylsulfoxide-d6
400 MHz
Karlsen, Morten; Liu, Huiling; Berg, Thomas; Johansen, Jon Eigill; Hoff, Bard Helge
Journal of Labelled Compounds and Radiopharmaceuticals, 2014 , vol. 57, # 5 p. 378 - 387 Title/Abstract Full Text View citing articles Show Details
Chemical shifts
13C
dimethylsulfoxide-d6
100 MHz
Karlsen, Morten; Liu, Huiling; Berg, Thomas; Johansen, Jon Eigill; Hoff, Bard Helge
Journal of Labelled Compounds and Radiopharmaceuticals, 2014 , vol. 57, # 5 p. 378 - 387 Title/Abstract Full Text View citing articles Show Details
Reference
Mass Spectrometry (1) Description (Mass Spectrometry)
Reference
high resolution mass spectrometry (HRMS) spectrum
Karlsen, Morten; Liu, Huiling; Berg, Thomas; Johansen, Jon Eigill; Hoff, Bard Helge
Journal of Labelled Compounds and Radiopharmaceuticals, 2014 , vol. 57, # 5 p. 378 - 387 Title/Abstract Full Text View citing articles Show Details