6. Chloroiodomethane [ClCH2I] by Asch

Query Query 1. Query

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Date

1 substances in Reaxys

2016-09-13 04h:20m:40s (EST)

Search as: As drawn, No salts, No mixtures, No isotopes, No charges, No radicals

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Reaxys ID 1730802 View in Reaxys

1/1 CAS Registry Number: 593-71-5 Chemical Name: Chloroiodomethane; chloriodomethane Linear Structure Formula: ClICH2 Molecular Formula: CH2ClI Molecular Weight: 176.384 Type of Substance: acyclic InChI Key: PJGJQVRXEUVAFT-UHFFFAOYSA-N Note:

Substance Label (14) Label References ClCH2I

Chinchilla, Rafael; Galindo, Nuria; Najera, Carmen; Synthesis; nb. 4; (1999); p. 704 - 717, View in Reaxys; Hirai, Go; Oguri, Hiroki; Hirama, Masahiro; Chemistry Letters; nb. 2; (1999); p. 141 - 142, View in Reaxys; Gerber, Patrick; Vogel, Pierre; Tetrahedron Letters; vol. 40; nb. 16; (1999); p. 3165 - 3168, View in Reaxys; Luk'yanov; Smirnov; Nikitin; Russian Chemical Bulletin; vol. 47; nb. 11; (1998); p. 2197 - 2200, View in Reaxys; Coxon, Geoffrey D.; Knobl, Stefan; Roberts, Evan; Baird, Mark S.; Al Dulayymi, Juma R.; Besra, Gurdyal S.; Brennan, Patrick J.; Minnikin, David E.; Tetrahedron Letters; vol. 40; nb. 36; (1999); p. 6689 - 6692, View in Reaxys; Piers; Coish; Synthesis; nb. 2; (2001); p. 251 - 261, View in Reaxys; Hutchings, Martin; Moffat, David; Simpkins, Nigel S.; Synlett; nb. 5; (2001); p. 661 - 663, View in Reaxys; Bieber, Lothar W.; De Sa, Ana C.P.F.; Menezes, Paulo H.; Goncalves, Simone M.C.; Tetrahedron Letters; vol. 42; nb. 28; (2001); p. 4597 - 4599, View in Reaxys; Lautens, Mark; Maddess, Matthew L.; Sauer, Effiette L. O.; Ouellet, Stephane G.; Organic Letters; vol. 4; nb. 1; (2002); p. 83 - 86, View in Reaxys; Coxon, Geoffrey D.; Al-Dulayymi, Juma R.; Baird, Mark S.; Knobl, Stefan; Roberts, Evan; Minnikin, David E.; Tetrahedron Asymmetry; vol. 14; nb. 9; (2003); p. 1211 - 1222, View in Reaxys; Fustero, Santos; Garcia Soler, Juan; Bartolome, Ana; Sanchez Rosello, Maria; Organic Letters; vol. 5; nb. 15; (2003); p. 2707 2710, View in Reaxys; Smith III, Amos B.; Xian, Ming; Liu, Fenghua; Organic Letters; vol. 7; nb. 21; (2005); p. 4613 - 4616, View in Reaxys; El Sheikh, Sherif; Kausch, Nina; Lex; Neudoerfl; Schmalz, HansGuenther; Synlett; nb. 10; (2006); p. 1527 - 1530, View in Reaxys; Haak, Robert M.; Tarabiono, Chiara; Janssen, Dick B.; Minnaard, Adriaan J.; De Vries, Johannes G.; Feringa, Ben L.; Organic and Biomolecular Chemistry; vol. 5; nb. 2; (2007); p. 318 - 323, View in Reaxys; Walker, Daniel P.; Acker, Brad A.; Jacobsen, E. Jon; Wishka, Donn G.; Journal of Heterocyclic Chemistry; vol. 45; nb. 1; (2008); p. 247 - 257, View in Reaxys; Tao, Daniel J.; Slutskyy, Yuriy; Overman, Larry E.; Journal of the American Chemical Society; vol. 138; nb. 7; (2016); p. 2186 - 2189, View in Reaxys

Nishimura, Rodolfo H.V.; Toledo, Fabiano T.; Lopes, Joao L.C.; Clososki, Giuliano C.; Tetrahedron Letters; vol. 54; nb. 4; (2013); p. 287 - 290, View in Reaxys; Degennaro, Leonardo; Fanelli, Flavio; Giovine, Arianna; Luisi, Renzo; Advanced Synthesis and Catalysis; vol. 357; nb. 1; (2015); p. 21 - 27, View in Reaxys

Brown, Christopher A.; Aggarwal, Varinder K.; Chemistry - A European Journal; vol. 21; nb. 40; (2015); p. 13900 - 13903, View in Reaxys

ICH&2%Cl

Wang, Yizhong; Wang, Chao; Butler, John R.; Ready, Joseph M.; Angewandte Chemie - International Edition; vol. 52; nb. 41; (2013); p. 10796 - 10799; Angew. Chem.; vol. 52-41; (2013); p. 10796 - 10799,4, View in Reaxys

Song, Zhenlei; Lu, Ting; Hsung, Richard P.; Al-Rashid, Ziyad F.; Ko, Changhong; Tang, Yu; Angewandte Chemie - International Edition; vol. 46; nb. 22; (2007); p. 4069 - 4072, View in Reaxys

t.3, RI, entry 6

Yajima, Tomoko; Saito, Chiaki; Nagano, Hajime; Tetrahedron; vol. 61; nb. 43; (2005); p. 10203 - 10215, View in Reaxys

CH2ClI

Luithle; Pietruszka; Journal of Organic Chemistry; vol. 65; nb. 26; (2000); p. 9194 - 9200, View in Reaxys; Concellon, Jose M.; Rodriguez-Solla, Humberto; Huerta, Monica; Perez-Andres, Juan A.; European Journal of Organic Chemistry; nb. 11; (2002); p. 1839 - 1847, View in Reaxys; Tian, Shan Xi; Kishimoto, Naoki; Ohno, Koichi; Journal of Physical Chemistry A; vol. 107; nb. 4; (2003); p. 485 - 493, View in Reaxys; Lin, Xufeng; Guan, Xiangguo; Kwok, Wai Ming; Zhao, Cunyuan; Du, Yong; Li, Yun-Liang; Phillips, David Lee; Journal of Physical Chemistry A; vol. 109; nb. 6; (2005); p. 981 - 998, View in Reaxys

CH2ICl

Vendeville, Sandrine; Goossens, Filip; Debreu-Fontaine, Marie-Ange; Landry, Valerie; Davioud-Charvet, Elisabeth; Grellier, Philippe; Scharpe, Simon; Sergheraert, Christian; Bioorganic and Medicinal Chemistry; vol. 10; nb. 6; (2002); p. 1719 - 1729, View in Reaxys; Senapati, Dulal; Kavita; Das, Puspendu K.; Journal of Physical Chemistry A; vol. 106; nb. 36; (2002); p. 8479 - 8482, View in Reaxys; Pietruszka, Joerg; Witt, Andreas; Frey, Wolfgang; European Journal of Organic Chemistry; nb. 16; (2003); p. 3219 3229, View in Reaxys; Bellenie, Benjamin R.; Goodman, Jonathan M.; Chemical Communications; nb. 9; (2004); p. 1076 - 1077, View in Reaxys; Guan, Xiangguo; Du, Yong; Li, Yun-Liang; Kwok, Wai Ming; Phillips, David Lee; Journal of Chemical Physics; vol. 121; nb. 17; (2004); p. 8399 - 8409, View in Reaxys; Lago; Kercher, James P.; Boedi, Andras; Sztaray, Balint; Miller; Wurzelmann; Baer, Tomas; Journal of Physical Chemistry A; vol. 109; nb. 9; (2005); p. 1802 - 1809, View in Reaxys

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Patent; Ueda, Yasutsugu; Connolly, Timothy P.; Kadow, John F.; Meanwell, Nicholas A.; Wang, Tao; Chen, Chung-Pin H.; Yeung, Kap-Sun; Zhang, Zhongxing; Leahy, David Kenneth; Pack, Shawn K.; Soundararajan, Nachimuthu; Sirard, Pierre; Levesque, Kathia; Thoraval, Dominique; US2005/209246; (2005); (A1) English, View in Reaxys

educt to 26

Breitfelder, Steffen; Schuemacher, Anne C.; Roelle, Thomas; Kikuchi, Makoto; Hoffmann, Reinhard W.; Helvetica Chimica Acta; vol. 87; nb. 5; (2004); p. 1202 - 1213, View in Reaxys

ICH2Cl

Raeppel, Franck; Weibel, Jean-Marc; Heissler, Denis; Tetrahedron Letters; vol. 40; nb. 35; (1999); p. 6377 - 6381, View in Reaxys; Cossy, Janine; Blanchard, Nicolas; Meyer, Christophe; Synthesis; nb. 6; (1999); p. 1063 - 1075, View in Reaxys; Gerber, Patrick; Vogel, Pierre; Helvetica Chimica Acta; vol. 84; nb. 6; (2001); p. 1363 - 1395, View in Reaxys; Cossy, Janine; Blanchard, Nicolas; Meyer, Christophe; Tetrahedron Letters; vol. 43; nb. 10; (2002); p. 1801 - 1805, View in Reaxys; Gerber-Lemaire, Sandrine; Ainge, Simon W.; Glanzmann, Cecile; Vogel, Pierre; Helvetica Chimica Acta; vol. 85; nb. 2; (2002); p. 417 - 430, View in Reaxys

Kedrowski, Brant L.; Heathcock, Clayton H.; Heterocycles; vol. 58; (2002); p. 601 - 634, View in Reaxys

RX, c- CH2Cl, X=I

Paradisi, Francesca; Porzi, Gianni; Sandri, Sergio; Tetrahedron Asymmetry; vol. 12; nb. 23; (2001); p. 3319 - 3324, View in Reaxys

educt to 3, ICH2Cl

Cossy, Janine; Blanchard, Nicolas; Meyer, Christophe; European Journal of Organic Chemistry; nb. 2; (2001); p. 339 - 348, View in Reaxys

Patent-Specific Data (2) Location in Patent References Page/Page column

Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HAHN, Michael; LAMPE, Thomas; STASCH, Johannes-Peter; SCHLEMMER, Karl-Heinz; WUNDER, Frank; LI, Volkhart Min-Jian; BECKER, Eva-Maria; STOLL, Friederike; KNORR, Andreas; WOLTERING, Elisabeth; US2013/79412; (2013); (A1) English, View in Reaxys; Patent; Helsinn Healthcare SA; Fadini, Luca; Manini, Peter; Pietra, Claudio; Giuliano, Claudio; Lovati, Emanuela; Cannella, Roberta; Venturini, Alessio; Stella, Valentino J.; US8426450; (2013); (B1) English, View in Reaxys; Patent; Bristol-Myers Squibb Company; Hewawasam, Piyasena; Kadow, John F.; Lopez, Omar D.; Meanwell, Nicholas A.; Tu, Yong; Wang, Alan Xiangdong; Xu, Ningning; Gupta, Samayamunthula Venkata Satya Arun Kumar; Srinivasu, Pothukanuri; Kumar, Indasi Gopi; Kumar, Ponugupati Suresh; Belema, Makonen; Fridell, Robert A.; Gao, Min; Lemm, Julie A.; O'Boyle, II, Donald R.; Sun, Jin-Hua; Wang, Chunfu; Wang, Ying-Kai; US2013/183269; (2013); (A1) English, View in Reaxys; Patent; Liverton, Nigel J.; McComas, Casey Cameron; Habermann, Joerg; Koch, Uwe; Narjes, Frank; Li, Peng; Peng, Xuanjia; Soll, Richard; Wu, Hao; Palani, Anandan; He, Shuwen; Dai, Xing; Liu, Hong; Lai, Zhong; London, Clare; Xiao, Dong; Zorn, Nicolas; Nargund, Ravi; US2014/213571; (2014); (A1) English, View in Reaxys; Patent; Hendricks, Robert Than; Beigelman, Leonid; Smith, David Bernard; Stoycheva, Antitsa Dimitrova; US2015/72982; (2015); (A1) English, View in Reaxys; Patent; The University of Kansas; Tanol, Mehmet; Weir, Scott J.; US2015/111858; (2015); (A1) English, View in Reaxys; Patent; Hartman, George D.; US2015/197493; (2015); (A1) English, View in Reaxys; Patent; Genentech, Inc.; Fauber, Benjamin; Gobbi, Alberto; Rene, Olivier; Bodil van Niel, Monique; Gancia, Emanuela; Gaines, Simon; Laddywahetty, Tammy; Vesey, David; Ward, Stuart; Winship, Paul; US2015/197529; (2015); (A1) English, View in Reaxys Patent; G.D. Searle and Co.; US6337398; (2002); (B1) English, View in Reaxys

Boiling Point (11) Boiling Point [°C] Pressure (Boiling Point) [Torr]

References

108 - 110

760

Tundo, Pietro; Venturello, Paolo; Angeletti, Enrico; Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999); (1983); p. 485 - 492, View in Reaxys

35 - 40

Landini; Rolla; Chemistry and Industry (London, United Kingdom); (1974); p. 533, View in Reaxys

108 - 110

760

Landini; Rolla; Chemistry and Industry (London, United Kingdom); (1974); p. 533, View in Reaxys

54 - 56

110

Altabev et al.; Chemistry and Industry (London, United Kingdom); (1973); p. 331, View in Reaxys

109 - 111

755

Altabev et al.; Chemistry and Industry (London, United Kingdom); (1973); p. 331, View in Reaxys

108 - 109

760

Miyano; Hashimoto; Bulletin of the Chemical Society of Japan; vol. 44; (1971); p. 2864, View in Reaxys

108

Kosower; Schwager; Journal of the American Chemical Society; vol. 86; (1964); p. 5528,5529, View in Reaxys; Miyano et al.; Journal of Organometallic Chemistry; vol. 12; (1968); p. 263, View in Reaxys

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107 - 108

760

Wittig; Wingler; Justus Liebigs Annalen der Chemie; vol. 656; (1962); p. 18,21, View in Reaxys

108

760

Wittig,G.; Schwarzenbach,K.; Justus Liebigs Annalen der Chemie; vol. 650; (1961); p. 1 - 20, View in Reaxys

108.7 - 109.3

760

Bacher; Wagner; Zeitschrift fuer Physikalische Chemie, Abteilung B: Chemie der Elementarprozesse, Aufbau der Materie; vol. 43; (1939); p. 195,197, View in Reaxys

109

Sakurai; Journal of the Chemical Society; vol. 47; (1885); p. 198 Anm., View in Reaxys

Refractive Index (3) Refractive Index Wavelength (Refractive Index) [nm]

Temperature (Refractive Index) [°C]

References

1.5822

589

Stevels; Transactions of the Faraday Society; vol. 33; (1937); p. 1382, View in Reaxys; Altabev et al.; Chemistry and Industry (London, United Kingdom); (1973); p. 331, View in Reaxys

1.582

589

Wittig,G.; Schwarzenbach,K.; Justus Liebigs Annalen der Chemie; vol. 650; (1961); p. 1 - 20, View in Reaxys; Wittig; Wingler; Justus Liebigs Annalen der Chemie; vol. 656; (1962); p. 18,21, View in Reaxys

1.5875

589

Bacher; Wagner; Zeitschrift fuer Physikalische Chemie, Abteilung B: Chemie der Elementarprozesse, Aufbau der Materie; vol. 43; (1939); p. 195,197, View in Reaxys

Density (4) 1 of 4

Density [g·cm-3]

2.422

Reference Temperature [°C]

Measurement Temperature [°C]

Stevels; Transactions of the Faraday Society; vol. 33; (1937); p. 1382, View in Reaxys; Stevels; Transactions of the Faraday Society; vol. 67; (1945); p. 1912, View in Reaxys 2 of 4

Density [g·cm-3]

2.447

Reference Temperature [°C]

Measurement Temperature [°C]

Sakurai; Journal of the Chemical Society; vol. 47; (1885); p. 198 Anm., View in Reaxys 3 of 4

Density [g·cm-3]

2.444

Reference Temperature [°C]

14.5

Measurement Temperature [°C]

14.5

Sakurai; Journal of the Chemical Society; vol. 47; (1885); p. 198 Anm., View in Reaxys 4 of 4

Density [g·cm-3]

2.49

Measurement Temperature [°C]

Sakurai; Journal of the Chemical Society; vol. 41; (1882); p. 362, View in Reaxys Adsorption (MCS) (3) 1 of 3

Description (Adsorption (MCS))

Desorption

Partner (Adsorption (MCS))

Pt(111)

Zhou; Liu; Kiss; Sloan; White; Journal of the American Chemical Society; vol. 117; nb. 12; (1995); p. 3565 - 3592, View in Reaxys

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2 of 3

Description (Adsorption (MCS))

Further physical properties of the adsorbed molecule

Partner (Adsorption (MCS))

Pt(111)

Zhou; Liu; Kiss; Sloan; White; Journal of the American Chemical Society; vol. 117; nb. 12; (1995); p. 3565 - 3592, View in Reaxys 3 of 3

Description (Adsorption (MCS))

Chemisorption

Partner (Adsorption (MCS))

Zhou, X.-L.; White, J. M.; Journal of Physical Chemistry; vol. 95; nb. 14; (1991); p. 5575 - 5580, View in Reaxys Association (MCS) (2) 1 of 2

Description (Association IR spectrum of the complex (MCS)) Solvent (Association (MCS))

various solvent(s)

Temperature (Association (MCS)) [°C]

-259.2

Partner (Association (MCS))

Clark, Robin J. H.; Dann, Jonathan R.; Journal of Physical Chemistry A; vol. 101; nb. 11; (1997); p. 2074 - 2082, View in Reaxys 2 of 2

Description (Association IR spectrum of the complex (MCS)) Solvent (Association (MCS))

various solvent(s)

Temperature (Association (MCS)) [°C]

-259.2

Partner (Association (MCS))

(18)O3

Clark, Robin J. H.; Dann, Jonathan R.; Journal of Physical Chemistry A; vol. 101; nb. 11; (1997); p. 2074 - 2082, View in Reaxys Chromatographic Data (1) Chromatographic Location data GC (Gas chroma- supporting infortography) mation

References Zheng, Bin; Sugiyama, Masano; Eastgate, Martin D.; Fritz, Alan; Murugesan, Saravanababu; Conlon, David A.; Organic Process Research and Development; vol. 16; nb. 11; (2012); p. 1827 - 1831, View in Reaxys

Critical Pressure (1) Critical Pressure References [Torr] 48678.9

Sladkov, I. B.; Kal'ko, O. A.; Russian Journal of Applied Chemistry; vol. 66; nb. 2.1; (1993); p. 277 - 281; Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation); vol. 66; nb. 2; (1993); p. 341 - 345, View in Reaxys

Critical Temperature (1) Critical Tempera- References ture [°C] 348.85

Critical Volume (1) Critical Volume [l/ References mol] 0.226

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Cross-Sections (1) Description References (Cross-Sections) Collision crosssection

Rattigan, Oliver V.; Shallcross, Dudley E.; Cox, R. Anthony; Journal of the Chemical Society - Faraday Transactions; vol. 93; nb. 16; (1997); p. 2839 - 2846, View in Reaxys

Enthalpy of Formation (3) Enthalpy of ForTemperature (Enmation [Jmol-1] thalpy of Formation) [°C]

References

10700

24.85

Lago; Kercher, James P.; Boedi, Andras; Sztaray, Balint; Miller; Wurzelmann; Baer, Tomas; Journal of Physical Chemistry A; vol. 109; nb. 9; (2005); p. 1802 - 1809, View in Reaxys

18800

-273.15

Lago; Kercher, James P.; Boedi, Andras; Sztaray, Balint; Miller; Wurzelmann; Baer, Tomas; Journal of Physical Chemistry A; vol. 109; nb. 9; (2005); p. 1802 - 1809, View in Reaxys Papulov et al.; Journal of Structural Chemistry; vol. 13; (1972); p. 655,658; ; p. 709, View in Reaxys

Enthalpy of Vaporization (1) Enthalpy of VaTemperature (Enporization thalpy of Vapori[Jmol-1] zation) [°C] 34000

108.9

References

Stoelevik, Reidar; Acta Chemica Scandinavica; vol. 43; nb. 9; (1989); p. 860 - 867, View in Reaxys

Further Information (1) Description (Fur- References ther Information) Further information

El-Sabban et al.; Journal of Chemical Physics; vol. 44; (1966); p. 1770,1779, View in Reaxys

Heat Capacity Cp0 (2) Heat Capacity Temperature Cp0 [Jmol-1K-1] (Heat Capacity Cp0) [°C] 38.1 - 96.55

References

-173.1 - 1226.9

Gelles; Pitzer; Journal of the American Chemical Society; vol. 75; (1953); p. 5259,5262-5267; Journal of the American Chemical Society; vol. 76; (1954); p. 6419, View in Reaxys

-173.1 - 1226.9

Gelles; Pitzer; Journal of the American Chemical Society; vol. 75; (1953); p. 5259,5262-5267; Journal of the American Chemical Society; vol. 76; (1954); p. 6419, View in Reaxys

Henry Constant (MCS) (3) 1 of 3

Temperature (Henry Constant (MCS)) [°C]

Solvent (Henry Constant solution (MCS)) Comment (Henry Constant (MCS))

Constant: 0.0122non-dimensional

Moore; Geen; Tait; Chemosphere; vol. 30; nb. 6; (1995); p. 1183 - 1191, View in Reaxys 2 of 3

Temperature (Henry Constant (MCS)) [°C]

Solvent (Henry Constant solution (MCS)) Comment (Henry Constant (MCS))

Constant: 0.0217non-dimensional

Moore; Geen; Tait; Chemosphere; vol. 30; nb. 6; (1995); p. 1183 - 1191, View in Reaxys 3 of 3

Temperature (Henry Constant (MCS)) [°C]

Solvent (Henry Constant solution (MCS))

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Comment (Henry Constant (MCS))

Constant: 0.0356non-dimensional

Moore; Geen; Tait; Chemosphere; vol. 30; nb. 6; (1995); p. 1183 - 1191, View in Reaxys Ionization Potential (1) Ionization Poten- References tial [eV] 9.752

Lago; Kercher, James P.; Boedi, Andras; Sztaray, Balint; Miller; Wurzelmann; Baer, Tomas; Journal of Physical Chemistry A; vol. 109; nb. 9; (2005); p. 1802 - 1809, View in Reaxys

Molecular Deformation (1) Description (MoComment (Molec- References lecular Deforma- ular Deformation) tion) Fundamental vibrations

des Molekuels.

Pitzer; Gelles; Journal of Chemical Physics; vol. 21; (1953); p. 855, View in Reaxys

Other Thermochemical Data (1) Description (Oth- References er Thermochemical Data) Thermodynamic properties

El-Sabban et al.; Journal of Chemical Physics; vol. 44; (1966); p. 1770,1779, View in Reaxys; Maslov; Maslov; Russian Journal of Physical Chemistry; vol. 45; (1971); p. 611, View in Reaxys

NMR Spectroscopy (3) 1 of 3

Description (NMR Spec- Spectrum troscopy) Nucleus (NMR Spectroscopy)

Solvents (NMR Spectro- D2O scopy) Comment (NMR Spectroscopy)

ambient temperature

Lin, Xufeng; Guan, Xiangguo; Kwok, Wai Ming; Zhao, Cunyuan; Du, Yong; Li, Yun-Liang; Phillips, David Lee; Journal of Physical Chemistry A; vol. 109; nb. 6; (2005); p. 981 - 998, View in Reaxys; Guan, Xiangguo; Du, Yong; Li, Yun-Liang; Kwok, Wai Ming; Phillips, David Lee; Journal of Chemical Physics; vol. 121; nb. 17; (2004); p. 8399 - 8409, View in Reaxys 2 of 3

Description (NMR Spec- Spectrum troscopy) Nucleus (NMR Spectroscopy)

Solvents (NMR Spectro- dimethylsulfoxide-d6 scopy) Miyano, Sotaro; Hokari, Hiroshi; Hashimoto, Harukichi; Bulletin of the Chemical Society of Japan; vol. 55; nb. 2; (1982); p. 534 - 539, View in Reaxys 3 of 3

Description (NMR Spec- Chemical shifts troscopy) Nucleus (NMR Spectroscopy)

Ebsworth,E.A.V. et al.; Journal of the Chemical Society [Section] A: Inorganic, Physical, Theoretical; (1968); p. 2294 - 2297, View in Reaxys; Friedrich, Edwin C.; Abma, Charles B.; Journal of the American Chemical Society; vol. 102; nb. 4; (1980); p. 1367 - 1371, View in Reaxys IR Spectroscopy (8) 1 of 8

Description (IR Spectroscopy)

Spectrum

Solvent (IR Spectroscopy)

various solvent(s)

Temperature (IR Spectroscopy) [°C]

-259.2

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Comment (IR Spectroscopy)

3800 - 650 cm**(-1)

Clark, Robin J. H.; Dann, Jonathan R.; Journal of Physical Chemistry A; vol. 101; nb. 11; (1997); p. 2074 - 2082, View in Reaxys 2 of 8

Description (IR Spectroscopy)

Bands

Solvent (IR Spectroscopy)

various solvent(s)

Temperature (IR Spectroscopy) [°C]

-259.2

Comment (IR Spectroscopy)

4448 - 540 cm**(-1)

Clark, Robin J. H.; Dann, Jonathan R.; Journal of Physical Chemistry A; vol. 101; nb. 11; (1997); p. 2074 - 2082, View in Reaxys 3 of 8

Description (IR Spectroscopy)

Bands

Solvent (IR Spectroscopy)

various solvent(s)

Temperature (IR Spectroscopy) [°C]

-259.2

Comment (IR Spectroscopy)

4435 - 541 cm**(-1)

Clark, Robin J. H.; Dann, Jonathan R.; Journal of Physical Chemistry A; vol. 101; nb. 11; (1997); p. 2074 - 2082, View in Reaxys 4 of 8

Description (IR Spectroscopy)

Bands

Comment (IR Spectroscopy)

753 cm**(-1)

Maier, Guenther; Reisenauer, Hans Peter; Hu, Jiani; Schaad, L. J.; Hess, B. Andes; Journal of the American Chemical Society; vol. 112; nb. 13; (1990); p. 5117 - 5122, View in Reaxys 5 of 8

Description (IR Spectroscopy)

Spectrum

Solvent (IR Spectroscopy)

solid matrix

Temperature (IR Spectroscopy) [°C]

Comment (IR Spectroscopy)

1200 - 500 cm**(-1)

Maier, Guenther; Reisenauer, Hans Peter; Angewandte Chemie; vol. 98; nb. 9; (1986); p. 829 - 831, View in Reaxys 6 of 8

Description (IR Spectroscopy)

Altabev et al.; Chemistry and Industry (London, United Kingdom); (1973); p. 331, View in Reaxys 7 of 8

Description (IR Spectroscopy)

Spectrum

Andrews; Smith; Journal of Chemical Physics; vol. 53; (1970); p. 2956, View in Reaxys 8 of 8

Description (IR Spectroscopy)

Bands

Jones et al.; Spectrochimica Acta; vol. 20; (1964); p. 1697,1700, View in Reaxys Mass Spectrometry (1) Description (Mass References Spectrometry)

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collision-induced dissociation

Tian, Shan Xi; Kishimoto, Naoki; Ohno, Koichi; Journal of Physical Chemistry A; vol. 107; nb. 4; (2003); p. 485 - 493, View in Reaxys

UV/VIS Spectroscopy (7) 1 of 7

Description (UV/VIS Spectroscopy)

Spectrum

Solvent (UV/VIS Spectroscopy)

H2O

Lin, Xufeng; Guan, Xiangguo; Kwok, Wai Ming; Zhao, Cunyuan; Du, Yong; Li, Yun-Liang; Phillips, David Lee; Journal of Physical Chemistry A; vol. 109; nb. 6; (2005); p. 981 - 998, View in Reaxys 2 of 7

Description (UV/VIS Spectroscopy)

Spectrum

Comment (UV/VIS Spectroscopy)

gas

Senapati, Dulal; Kavita; Das, Puspendu K.; Journal of Physical Chemistry A; vol. 106; nb. 36; (2002); p. 8479 8482, View in Reaxys 3 of 7

Comment (UV/VIS Spectroscopy)

gas

Absorption Maxima (UV/ 173; 192; 271 VIS) [nm] Senapati, Dulal; Kavita; Das, Puspendu K.; Journal of Physical Chemistry A; vol. 106; nb. 36; (2002); p. 8479 8482, View in Reaxys 4 of 7

Description (UV/VIS Spectroscopy)

Spectrum

Solvent (UV/VIS Spectroscopy)

acetonitrile

Description (UV/VIS Spectroscopy)

Spectrum

Solvent (UV/VIS Spectroscopy)

cyclohexane

Comment (UV/VIS Spectroscopy)

200 - 360 nm

Kwok, Wai Ming; Phillips, David Lee; Journal of Chemical Physics; vol. 104; nb. 24; (1996); p. 9816 - 9832, View in Reaxys 6 of 7

Description (UV/VIS Spectroscopy)

Spectrum

Solvent (UV/VIS Spectroscopy)

cyclohexane

Comment (UV/VIS Spectroscopy)

220 - 540 nm

Phillips, David Lee; Kwok, Wai Ming; Chemical Physics Letters; vol. 241; nb. 4; (1995); p. 267 - 274, View in Reaxys 7 of 7

Description (UV/VIS Spectroscopy)

Absorption maxima

Kosower; Schwager; Journal of the American Chemical Society; vol. 86; (1964); p. 5528,5529, View in Reaxys NQR Spectroscopy (1) Description (NQR References Spectroscopy) Nuclear quadrupole resonance

Babuschkina; Semin; Journal of Structural Chemistry; vol. 7; (1966); p. 107; Zhurnal Strukturnoi Khimii; vol. 7; (1966); p. 114, View in Reaxys; Feshin; Voronkov; Doklady Physical Chemistry; vol. 229; (1976); p. 667, View in Reaxys

Raman Spectroscopy (8)

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Description (Ram- Solvent (Raman an Spectroscopy) Spectroscopy)

Comment (Raman Spectroscopy)

Raman resonance effect

References Phillips, David Lee; Kwok, Wai Ming; Chemical Physics Letters; vol. 241; nb. 4; (1995); p. 267 - 274, View in Reaxys; Kwok, Wai Ming; Ma, Chensheng; Parker, Anthony W.; Phillips, David; Towrie, Michael; Matousek, Pavel; Zheng, Xuming; Phillips, David Lee; Journal of Chemical Physics; vol. 114; nb. 17; (2001); p. 7536 7543, View in Reaxys

Spectrum

acetonitrile

Bands

acetonitrile

time dependence

Kwok, Wai Ming; Ma, Chensheng; Parker, Anthony W.; Phillips, David; Towrie, Michael; Matousek, Pavel; Zheng, Xuming; Phillips, David Lee; Journal of Chemical Physics; vol. 114; nb. 17; (2001); p. 7536 - 7543, View in Reaxys Kwok, Wai Ming; Ma, Chensheng; Parker, Anthony W.; Phillips, David; Towrie, Michael; Matousek, Pavel; Zheng, Xuming; Phillips, David Lee; Journal of Chemical Physics; vol. 114; nb. 17; (2001); p. 7536 - 7543, View in Reaxys

Spectrum

cyclohexane

Phillips, David Lee; Kwok, Wai Ming; Chemical Physics Letters; vol. 241; nb. 4; (1995); p. 267 - 274, View in Reaxys; Kwok, Wai Ming; Phillips, David Lee; Journal of Chemical Physics; vol. 104; nb. 24; (1996); p. 9816 - 9832, View in Reaxys

Bands

cyclohexane

Raman intensities

Spectrum

Wagner; Zeitschrift fuer Physikalische Chemie, Abteilung B: Chemie der Elementarprozesse, Aufbau der Materie; vol. 34; (1940); p. 77,81, View in Reaxys; Bacher; Wagner; Zeitschrift fuer Physikalische Chemie, Abteilung B: Chemie der Elementarprozesse, Aufbau der Materie; vol. 43; (1939); p. 195,197, View in Reaxys

Degree of depolarization of Raman bands

Wagner; Zeitschrift fuer Physikalische Chemie, Abteilung B: Chemie der Elementarprozesse, Aufbau der Materie; vol. 45; p. 77,89, View in Reaxys

Other Spectroscopic Methods (1) Description (Oth- References er Spectroscopic Methods) ESCA

Zhou; Liu; Kiss; Sloan; White; Journal of the American Chemical Society; vol. 117; nb. 12; (1995); p. 3565 - 3592, View in Reaxys

Pharmacological Data (37) 1 of 37

Comment (Pharmacological Data)

Bioactivities present

Patent; BODOR, Nicholas S.; EP334853; (1989); (A1) English, View in Reaxys; Patent; Glaxo Laboratories Limited; US4093721; (1978); (A1) English, View in Reaxys; Patent; Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab); US4325960; (1982); (A1) English, View in Reaxys; Patent; Pfizer Inc.; US4244951; (1981); (A1) English, View in Reaxys; Patent; Pfizer Inc.; US4444686; (1984); (A1) English, View in Reaxys; Simmons,H.E. et al.; Journal of the American Chemical Society; vol. 86; (1964); p. 1347 - 1356, View in Reaxys; Patent; Pfizer Inc.; US4551452; (1985); (A1) English, View in Reaxys; Patent; Lovens Kemiske Fabrik Produktionsaktieselskab; US4554160; (1985); (A1) English, View in Reaxys; Wittig,G.; Schwarzenbach,K.; Justus Liebigs Annalen der Chemie; vol. 650; (1961); p. 1 - 20, View in Reaxys; Patent; Otsuka Pharmaceutical Co., Ltd.; US4710495; (1987); (A1) English, View in Reaxys; Wheeler,W.J. et al.; Journal of Medicinal Chemistry; vol. 22; (1979); p. 657 - 661, View in Reaxys; Patent; G.D. Searle and Co.; US5705500; (1998); (A1) English, View in Reaxys; Patent; Ligand Pharmaceuticals Incorporated; The Regents of the University of California; US5808139; (1998); (A1) English, View in Reaxys; Miyano,S. et al.; Bulletin of the Chemical Society of Japan; vol. 52; (1979); p. 1197 - 1202, View in Reaxys; Patent; Bristol-Myers Squibb Company; US6235728; (2001); (B1) English, View in Reaxys; Lyons,J.E.; Journal of the Chemical Society, Chemical Communications; (1975); p. 418 - 419, View in Reaxys; Patent; Soft Drugs, Inc.; US5981517; (1999); (A1) English, View in Reaxys; Patent; University of Kansas; US5985856; (1999); (A1) English, View in Reaxys; Patent; AB, Medivir;

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US2002/128301; (2002); (A1) English, View in Reaxys; Blanchard,E.P. et al.; Journal of Organic Chemistry; vol. 30; (1965); p. 4321 - 4322, View in Reaxys 2 of 37

Comment (Pharmacological Data)

Bioactivities present

Patent; Mueller, Werner; Neidhart, Werner; Pflieger, Philippe; Plancher, Jean-Marc; US2002/198194; (2002); (A1) English, View in Reaxys; Patent; Medivir AB; US6486183; (2002); (B1) English, View in Reaxys; Patent; Reeder, Michael R.; US2003/4360; (2003); (A1) English, View in Reaxys; Patent; Kang, Myung-Gyun; Park, DooHee; Kwon, Oh-Hwan; Kim, Eunice Eun-Kyeong; Hwang, Kwang-Yeon; Heo, Yong-Seok; Park, Tae-Kyo; Lee, Tae-Hee; Moon, Kwang-Yul; Park, Jong-Woo; Chang, Hye-Kyung; Lee, Sang-Koo; Lee, Sun-Hwa; Park, SuKyung; Lee, Sung-Hack; Park, Hae-Dong; US2003/65176; (2003); (A1) English, View in Reaxys; Patent; Merck and Co., Inc.; US6610692; (2003); (B1) English, View in Reaxys; Patent; G. D. Searle and Co.; US6388132; (2002); (B1) English, View in Reaxys; Patent; THE UNIVERSITY OF KANSAS; EP1051181; (2004); (B1) English, View in Reaxys; Ebsworth,E.A.V. et al.; Journal of the Chemical Society [Section] A: Inorganic, Physical, Theoretical; (1968); p. 2294 - 2297, View in Reaxys; Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2004/52850; (2004); (A2) English, View in Reaxys; Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2005/12249; (2005); (A2) English, View in Reaxys; Patent; CONFORMA THERAPEUTICS CORPORATION; WO2005/28434; (2005); (A2) English, View in Reaxys; Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2005/49585; (2005); (A1) English, View in Reaxys; Patent; Pharmacia Corporation; US6921767; (2005); (B2) English, View in Reaxys; Patent; ELAN PHARMACEUTICALS, INC.; WO2005/87751; (2005); (A2) English, View in Reaxys; Patent; CYTOKINETICS, INC.; SMITHKLINE BEECHAM CORPORATION; WO2005/107762; (2005); (A2) English, View in Reaxys; Patent; IRM LLC; WO2006/15259; (2006); (A2) English, View in Reaxys; Patent; MERCK FROSST CANADA LTD.; WO2006/63466; (2006); (A1) English, View in Reaxys; Patent; Ube Industries, Ltd.; SANTEN PHARMACEUTICAL CO., LTD.; EP1679308; (2006); (A1) English, View in Reaxys; Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2006/74940; (2006); (A2) English, View in Reaxys; Patent; BIOLIPOX AB; WO2006/77364; (2006); (A1) English, View in Reaxys 3 of 37

Comment (Pharmacological Data)

Bioactivities present

Patent; BIOLIPOX AB; WO2006/77367; (2006); (A1) English, View in Reaxys; Patent; Chiu, George; Li, Shengjian; Connolly, Peter J.; Pulito, Virginia L.; Liu, Jingchun; Middleton, Steven A.; US2006/217419; (2006); (A1) English, View in Reaxys; Patent; MERCK and CO., INC.; MERCK FROSST CANADA LTD.; WO2006/98912; (2006); (A1) English, View in Reaxys; Patent; ALANTOS PHARMACEUTICALS, INC.; WO2006/116157; (2006); (A2) English, View in Reaxys; Patent; ELI LILLY AND COMPANY; WO2006/107784; (2006); (A1) English, View in Reaxys; Patent; Kalla, Rao; Koltun, Dmitry; Zablocki, Jeff; Elzein, Elfatih; US2006/293283; (2006); (A1) English, View in Reaxys; Patent; SPEEDEL EXPERIMENTA AG; WO2007/31558; (2007); (A1) English, View in Reaxys; Patent; NeuroSearch A/S; WO2007/42546; (2007); (A1) English, View in Reaxys; Patent; MERCK FROSST CANADA LTD.; WO2007/59610; (2007); (A1) English, View in Reaxys; Patent; Majeed, Muhammed; Nagabushnam, Kalyanam; Ramanujam, Rajendran; Prakash, Subbalakshmi; US2007/155709; (2007); (A1) English, View in Reaxys; Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2007/77004; (2007); (A1) English, View in Reaxys; Patent; MERCK FROSST CANADA LTD.; WO2007/124589; (2007); (A1) English, View in Reaxys; Patent; NOVARTIS AG; NOVARTIS PHARMA GmbH; WO2008/9750; (2008); (A2) English, View in Reaxys; Patent; GLAXO GROUP LIMITED; WO2008/31772; (2008); (A1) English, View in Reaxys; Patent; XENON PHARMACEUTICALS INC.; WO2008/46046; (2008); (A1) English, View in Reaxys; Patent; XENON PHARMACEUTICALS INC.; WO2008/46049; (2008); (A1) English, View in Reaxys; Patent; XENON PHARMACEUTICALS INC.; WO2008/46087; (2008); (A2) English, View in Reaxys; Williams; Ravve; Journal of the American Chemical Society; vol. 70; (1948); p. 1244, View in Reaxys; Sakurai; Journal of the Chemical Society; vol. 41; (1882); p. 362, View in Reaxys; Sakurai; Journal of the Chemical Society; vol. 47; (1885); p. 198 Anm., View in Reaxys 4 of 37

Comment (Pharmacological Data)

Bioactivities present

Henry; Chemische Berichte; 24 Ref. <1891>,74, View in Reaxys; Forbes; Anderson; Journal of the American Chemical Society; vol. 67; (1945); p. 1912, View in Reaxys; Stevels; Transactions of the Faraday Society; vol. 33; (1937); p. 1382, View in Reaxys; Patent; du Pont de Nemours and Co.; US2440800; (1942), View in Reaxys; Wagner; Zeitschrift fuer Physikalische Chemie, Abteilung B: Chemie der Elementarprozesse, Aufbau der Materie; vol. 45; p. 77,89, View in Reaxys; Wagner; Zeitschrift fuer Physikalische Chemie, Abteilung B: Chemie der Elementarprozesse, Aufbau der Materie; vol. 34; (1940); p. 77,81, View in Reaxys; Stevels; Transactions of the Faraday Society; vol. 67; (1945); p. 1912, View in Reaxys; Bacher; Wagner; Zeitschrift fuer Physikalische Chemie, Abteilung B: Chemie der Elementarprozesse, Aufbau der Materie; vol. 43; (1939); p. 195,197, View in Reaxys; Hine et al.; Journal of the American Chemical Society; vol. 78; (1956); p. 2282, View in Reaxys; Hine et al.; Journal of the American Chemical Society; vol. 77; (1955); p. 3886,3889, View in Reaxys; Gelles; Pitzer; Journal of the American Chemical Society; vol. 75; (1953); p. 5259,5262-5267; Journal of the American Chemical Society; vol. 76; (1954); p. 6419, View in Reaxys; Harmon et al.; Journal of the American Chemical Society; vol. 72; (1950); p. 2213, View in Reaxys; Pitzer; Gelles; Journal of Chemical Physics; vol. 21; (1953); p. 855, View in Reaxys; Kosower et al.; Journal of the American Chemical Society; vol. 100; (1978); p. 1186,1192, View in Reaxys; Kosower; Schwager; Journal of the American Chemical Society; vol. 86; (1964); p. 5528,5529, View in Reaxys; Evans et al.; Journal of the American Chemical Society; vol. 82; (1960); p. 6414, View in Reaxys; Fox et al.; Transactions of the Faraday Society; vol. 57; (1961); p. 1915, View in Reaxys; Jones et al.; Spectrochimica Acta; vol. 20; (1964); p. 1697,1700, View in Reaxys; El-Sabban et al.; Journal of Chemical Physics; vol. 44; (1966); p. 1770,1779, View in Reaxys; Ba-

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buschkina; Semin; Journal of Structural Chemistry; vol. 7; (1966); p. 107; Zhurnal Strukturnoi Khimii; vol. 7; (1966); p. 114, View in Reaxys 5 of 37

Comment (Pharmacological Data)

Bioactivities present

Blanchard; Simmons; Journal of the American Chemical Society; vol. 86; (1964); p. 1337,1338, View in Reaxys; Miyano; Hashimoto; Bulletin of the Chemical Society of Japan; vol. 44; (1971); p. 2864, View in Reaxys; Hoberg; Justus Liebigs Annalen der Chemie; vol. 656; (1962); p. 15,16, View in Reaxys; Wittig; Wingler; Justus Liebigs Annalen der Chemie; vol. 656; (1962); p. 18,21, View in Reaxys; Feshin; Voronkov; Doklady Physical Chemistry; vol. 229; (1976); p. 667, View in Reaxys; Landini; Rolla; Chemistry and Industry (London, United Kingdom); (1974); p. 533, View in Reaxys; Altabev et al.; Chemistry and Industry (London, United Kingdom); (1973); p. 331, View in Reaxys; Herberich; Schwarzer; Journal of Organometallic Chemistry; vol. 34; (1972); p. C43, View in Reaxys; Andrews; Smith; Journal of Chemical Physics; vol. 53; (1970); p. 2956, View in Reaxys; Papulov et al.; Journal of Structural Chemistry; vol. 13; (1972); p. 655,658; ; p. 709, View in Reaxys; Maslov; Maslov; Russian Journal of Physical Chemistry; vol. 45; (1971); p. 611, View in Reaxys; Paterson et al.; Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999); (1978); p. 884,885-886, View in Reaxys; Ravey et al.; Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999); (1977); p. 1462,1463, View in Reaxys; Kawabata et al.; Bulletin of the Chemical Society of Japan; vol. 49; (1976); p. 3669, View in Reaxys; King; Braitsch; Journal of Organometallic Chemistry; vol. 54; (1973); p. 9,10, View in Reaxys; Dilling; Edamura; Chemical Communications (London); (1967); p. 183, View in Reaxys; Herberich et al.; Journal of Organometallic Chemistry; vol. 17; (1969); p. 445, View in Reaxys; Miyano et al.; Journal of Organometallic Chemistry; vol. 12; (1968); p. 263, View in Reaxys; Hahn; Tompkins; Tetrahedron Letters; vol. 31; nb. 7; (1990); p. 937 - 940, View in Reaxys; Amriev, R. A.; Velichko, F. K.; Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation); vol. 38; nb. 2.2; (1989); p. 428 - 429; Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya; nb. 2; (1989); p. 485 - 487, View in Reaxys 6 of 37

Comment (Pharmacological Data)

Bioactivities present

Barluenga, Jose; Llavona, Lujan; Concellon, Jose M.; Yus, Miguel; Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999); nb. 2; (1990); p. 417, View in Reaxys; Maier, Guenther; Reisenauer, Hans Peter; Hu, Jiani; Schaad, L. J.; Hess, B. Andes; Journal of the American Chemical Society; vol. 112; nb. 13; (1990); p. 5117 - 5122, View in Reaxys; Imai, Toshiro; Mineta, Hiroshi; Nishida, Shinya; Journal of Organic Chemistry; vol. 55; nb. 17; (1990); p. 4986 - 4988, View in Reaxys; Denmark, Scott E.; Edwards, James P.; Wilson, Scott R.; Journal of the American Chemical Society; vol. 113; nb. 2; (1991); p. 723 - 725, View in Reaxys; Kuwahara, Shigefumi; Mori, Kenji; Tetrahedron; vol. 46; nb. 24; (1990); p. 8083 - 8092, View in Reaxys; Barluenga, Jose; Llavona, Lujan; Concellon, Jose M.; Yus, Miguel; Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999); nb. 2; (1991); p. 297 - 300, View in Reaxys; Rakestraw, David, J.; Holmes, Bert E.; Journal of Physical Chemistry; vol. 95; nb. 10; (1991); p. 3968 - 3975, View in Reaxys; Burke, Steven D.; Piscopio, Anthony D.; Kort, Michael E.; Tetrahedron Letters; vol. 32; nb. 7; (1991); p. 855 - 856, View in Reaxys; Kitahara, Takeshi; Kiyota, Hiromasa; Kurata, Hitoshi; Mori, Kenji; Tetrahedron; vol. 47; nb. 9; (1991); p. 1649 - 1654, View in Reaxys; Bender, S. L.; Detty, M. R.; Haley, N. F.; Tetrahedron Letters; vol. 23; nb. 15; (1982); p. 1531 - 1534, View in Reaxys; Sadhu, Kizhakethil Mathew; Matteson, Donald S.; Tetrahedron Letters; vol. 27; nb. 7; (1986); p. 795 - 798, View in Reaxys; Barluenga, Jose; Fernandez-Simon, Jose L.; Concellon, Jose M.; Yus, Miguel; Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999); (1989); p. 77 - 80, View in Reaxys; Molander, Gary A.; Harring, Lori S.; Journal of Organic Chemistry; vol. 54; nb. 15; (1989); p. 3525 - 3532, View in Reaxys; Sekine, Mitsuo; Nakajima, Masashi; Hata, Tsujiaki; Journal of Organic Chemistry; vol. 46; nb. 20; (1981); p. 4030 - 4034, View in Reaxys; Shimamoto, Keiko; Ishida, Michiko; Shinozaki, Haruhikio; Ohfune, Yasufumi; Journal of Organic Chemistry; vol. 56; nb. 13; (1991); p. 4167 - 4176, View in Reaxys; Kabat; Kiegiel; Cohen; Toth; Wovkulich; Uskokovic; Tetrahedron Letters; vol. 32; nb. 21; (1991); p. 2343 - 2346, View in Reaxys; Werner, H.; Schippel, O.; Wolf, J.; Schultz, M.; Journal of Organometallic Chemistry; vol. 417; nb. 1/2; (1991); p. 149 - 162, View in Reaxys; Denmark, Scott E.; Edwards, James P.; Journal of Organic Chemistry; vol. 56; nb. 25; (1991); p. 6974 - 6981, View in Reaxys; Zhou, X.-L.; White, J. M.; Journal of Physical Chemistry; vol. 95; nb. 14; (1991); p. 5575 - 5580, View in Reaxys; Tundo, Pietro; Venturello, Paolo; Angeletti, Enrico; Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999); (1983); p. 485 - 492, View in Reaxys 7 of 37

Comment (Pharmacological Data)

Bioactivities present

Yang, Zhen-Yun; Young, G.Brent; Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999); (1984); p. 2019 - 2026, View in Reaxys; Barluenga, Jose; Fernandez-Simon, Jose L.; Concellon, Jose M.; Yus, Miguel; Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999); (1988); p. 3339 - 3344, View in Reaxys; Koelle, Ulrich; Khouzami, Fouad; Chemische Berichte; vol. 114; nb. 9; (1981); p. 2929 - 2937, View in Reaxys; Koelle, Ulrich; Khouzami, Fouad; Lueken, Heiko; Chemische Berichte; vol. 115; nb. 3; (1982); p. 1178 - 1196, View in Reaxys; Maier, Guenther; Reisenauer, Hans Peter; Angewandte Chemie; vol. 98; nb. 9; (1986); p. 829 - 831, View in Reaxys; Friedrich, Edwin C.; Abma, Charles B.; Journal of the American Chemical Society; vol. 102; nb. 4; (1980); p. 1367 - 1371, View in Reaxys; Matteson; Peterson; Journal of Organic Chemistry; vol. 52; nb. 23; (1987); p. 5116 - 5121, View in Reaxys; Hahn, Roger C.; Journal of Organic Chemistry; vol. 53; nb. 6; (1988); p. 1331 - 1333, View in Reaxys; Barluenga, Jose; Fernandez-Simon, Jose L.; Concellon, Jose M.; Yus, Miguel; Synthesis; nb. 6; (1987); p. 584 - 586, View in Reaxys; Winter, Charles

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2016-09-13 04:23:05

H.; Veal, William R.; Garner, Charles M.; Arif, Atta M.; Gladysz, J. A.; Journal of the American Chemical Society; vol. 111; nb. 13; (1989); p. 4766 - 4776, View in Reaxys; Denmark, Scott E.; Edwards, James P.; Wilson, Scott R.; Journal of the American Chemical Society; vol. 114; nb. 7; (1992); p. 2592 - 2602, View in Reaxys; Seetula, J. A.; Gutman, D.; Lightfoot, P. D.; Rayes, M. T.; Senkan, S. M.; Journal of Physical Chemistry; vol. 95; nb. 26; (1991); p. 10688 - 10693, View in Reaxys; Hughes; Toth; Ward; McColm; Cox; Anderson; Gibbons; Journal of Pharmaceutical Sciences; vol. 81; nb. 8; (1992); p. 845 - 847, View in Reaxys; Hahn, Roger C.; Tompkins, Jan; Journal of Organic Chemistry; vol. 53; nb. 24; (1988); p. 5783 - 5785, View in Reaxys; Ishihara; Yukimasa; Miyamoto; Goto; Chemical and Pharmaceutical Bulletin; vol. 40; nb. 5; (1992); p. 1177 - 1185, View in Reaxys; Mori, Kenji; Takikawa, Hirosato; Kido, Masaru; Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999); nb. 2; (1993); p. 169 - 180, View in Reaxys; De Kimpe; Stevens; Synthesis; nb. 1; (1993); p. 89 - 91, View in Reaxys; Zhang, Xin-Ping; Schlosser, Manfred; Tetrahedron Letters; vol. 34; nb. 12; (1993); p. 1925 - 1928, View in Reaxys; Monaghan, Patrick K; Puddephatt, Richard J.; Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999); (1988); p. 595 - 600, View in Reaxys; Paul, Wilfried; Werner, Helmut; Chemische Berichte; vol. 118; nb. 8; (1985); p. 3032 - 3040, View in Reaxys 8 of 37

Comment (Pharmacological Data)

Bioactivities present

Werner, Helmut; Paul, Wilfried; Feser, Rainer; Zolk, Ralf; Thometzek, Peter; Chemische Berichte; vol. 118; nb. 1; (1985); p. 261 - 274, View in Reaxys; Oppolzer, Wolfgang; Radinov, Rumen N.; Journal of the American Chemical Society; vol. 115; nb. 4; (1993); p. 1593 - 1594, View in Reaxys; Fenter, Frederick F.; Lightfoot, Phillip D.; Caralp, Francoise; Lesclaux, Robert; Niiranen, Jukka T.; Gutman, David; Journal of Physical Chemistry; vol. 97; nb. 18; (1993); p. 4695 - 4703, View in Reaxys; Barluenga, Jose; Pedregal, Bruno; Concellon, Jose M.; Tetrahedron Letters; vol. 34; nb. 28; (1993); p. 4563 - 4564, View in Reaxys; Detty, Michael R.; Haley, Neil F.; Eachus, Raymond S.; Hassett, James W.; Luss, Henry R.; at al.; Journal of the American Chemical Society; vol. 107; nb. 22; (1985); p. 6298 - 6304, View in Reaxys; Brown, Herbert C.; Phadke, Avinash S.; Rangaishenvi, Milind V.; Journal of the American Chemical Society; vol. 110; nb. 18; (1988); p. 6263 - 6264, View in Reaxys; Stoelevik, Reidar; Acta Chemica Scandinavica; vol. 43; nb. 9; (1989); p. 860 - 867, View in Reaxys; Freidlina, R. Kh.; Gasanov, R. G.; Amriev, R. A.; Velichko, F. K.; Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation); vol. 34; nb. 6; (1985); p. 1332; Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya; nb. 6; (1985); p. 1453 - 1454, View in Reaxys; Kermode, Nigel J.; Lappert, Michael F.; Skelton, Brian W.; White, Allan H.; Holton, John; Journal of the Chemical Society, Chemical Communications; nb. 14; (1981); p. 698 - 699, View in Reaxys; Amriev, R. A.; Velichko, F. K.; Baibuz, O. P.; Rilo, R. P.; Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation); vol. 33; nb. 12; (1984); p. 2501 - 2504; Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya; nb. 12; (1984); p. 2732 - 2736, View in Reaxys; Kanai; Nishiguchi; Matsuda; Bulletin of the Chemical Society of Japan; vol. 56; nb. 6; (1983); p. 1592 - 1597, View in Reaxys; Botha, Cheryl; Moss, John R.; Pelling, Simon; Journal of Organometallic Chemistry; vol. 220; nb. 2; (1981); p. C21 C24, View in Reaxys; Werner, H.; Paul, W.; Journal of Organometallic Chemistry; vol. 236; nb. 3; (1982); p. C71 C74, View in Reaxys; Grant, Andrew D.; Zacharias, David E.; Mascavage, Linda M.; Kemmerer, George E.; Dalton, David R.; Journal of Heterocyclic Chemistry; vol. 30; nb. 2; (1993); p. 553 - 557, View in Reaxys; Barluenga, Jose; Llavona, Lujan; Bernad, Pablo L.; Concellon, Jose M.; Tetrahedron Letters; vol. 34; nb. 19; (1993); p. 3173 - 3176, View in Reaxys; Charette; Marcoux; Tetrahedron Letters; vol. 34; nb. 45; (1993); p. 7157 - 7160, View in Reaxys; Rodriguez, Juan B.; Marquez, Victor E.; Nicklaus, Marc C.; Barchi, Joseph J.; Tetrahedron Letters; vol. 34; nb. 39; (1993); p. 6233 - 6236, View in Reaxys; Ermolenko, Mikhail S.; Olesker, Alain; Lukacs, Gabor; Tetrahedron Letters; vol. 35; nb. 5; (1994); p. 711 - 714, View in Reaxys; Weibel, Jean-Marc; Heissler, Denis; Tetrahedron Letters; vol. 35; nb. 3; (1994); p. 473 - 476, View in Reaxys; Charette, Andre B.; Turcotte, Nathalie; Marcoux, Jean-Francois; Tetrahedron Letters; vol. 35; nb. 4; (1994); p. 513 - 516, View in Reaxys 9 of 37

Comment (Pharmacological Data)

Bioactivities present

Herberich, Gerhard E.; Klein, Wolfram; Chemische Berichte; vol. 122; (1989); p. 2125 - 2128, View in Reaxys; Miyano, Sotaro; Mori, Akira; Hokari, Hiroshi; Ohta, Katsuaki; Hashimoto, Harukichi; Bulletin of the Chemical Society of Japan; vol. 55; nb. 4; (1982); p. 1331 - 1332, View in Reaxys; Engelter, Carola; Moss, John R.; Niven, Margaret L.; Nassimbeni, Luigi R.; Reid, Gordon; Journal of Organometallic Chemistry; vol. 232; nb. 4; (1982); p. C78 - C80, View in Reaxys; Moss, John R.; Pelling, Simon; Journal of Organometallic Chemistry; vol. 236; nb. 2; (1982); p. 221 - 228, View in Reaxys; Barluenga, Jose; Fernandez-Simon, Jose L.; Concellon, Jose M.; Yus, Miguel; Journal of the Chemical Society, Chemical Communications; nb. 22; (1986); p. 1665, View in Reaxys; Miyano, Sotaro; Hokari, Hiroshi; Hashimoto, Harukichi; Bulletin of the Chemical Society of Japan; vol. 55; nb. 2; (1982); p. 534 - 539, View in Reaxys; Miyano, Sotaro; Hokari, Hiroshi; Umeda, Yoshiharu; Hashimoto, Harukichi; Bulletin of the Chemical Society of Japan; vol. 53; nb. 3; (1980); p. 770 - 774, View in Reaxys; Ooi; Maruoka; Yamamoto; Tetrahedron; vol. 50; nb. 22; (1994); p. 6505 - 6522, View in Reaxys; Barluenga, Jose; Baragana, Beatriz; Alonso, Alejandro; Concellon, Jose M.; Journal of the Chemical Society, Chemical Communications; nb. 8; (1994); p. 969 - 970, View in Reaxys; Fadel; Tetrahedron Asymmetry; vol. 5; nb. 4; (1994); p. 531 - 534, View in Reaxys; Zhao, Yufen; Yang, Te-Fang; Lee, Migyoung; Chun, Byoung K.; Du, Jinfa; Schinazi, Raymond F.; Lee, Doowon; Gary Newton; Chu, Chung K.; Tetrahedron Letters; vol. 35; nb. 30; (1994); p. 5405 - 5408, View in Reaxys; Sladkov, I. B.; Kal'ko, O. A.; Russian Journal of Applied Chemistry; vol. 66; nb. 2.1; (1993); p. 277 - 281; Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation); vol. 66; nb. 2; (1993); p. 341 - 345, View in Reaxys; Gash, Rosslyn C.; Cole-Hamilton, David J.; Whyman, Robin; Barnes, John C.; Simpson, Michael C.; Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999); nb. 13; (1994); p. 1963 - 1970, View in Reaxys; Engelter, Carola; Moss, John R.; Nassimbeni, Luigi R.; Niven, Margaret L.; Reid, Gordon; Spiers, John C.; Journal of Organometallic Chemistry; vol. 315; (1986); p. 255 - 268, View in Reaxys;

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Werner, H.; Luxenburger, G.; Hofmann, W.; Nadvornik, M.; Journal of Organometallic Chemistry; vol. 323; (1987); p. 161 - 172, View in Reaxys; Lellouche, J. P.; Bulot, E.; Beaucourt, J. P.; Martelli, J.; Gree, R.; Journal of Organometallic Chemistry; vol. 342; (1988); p. C21 - C25, View in Reaxys; Barluenga, Jose; Bernad Jr., Pablo L.; Concellon, Jose M.; Tetrahedron Letters; vol. 35; nb. 50; (1994); p. 9471 - 9472, View in Reaxys; Soundararajan, Raman; Li, Guisheng; Brown, Herbert C.; Tetrahedron Letters; vol. 35; nb. 48; (1994); p. 8957 - 8960, View in Reaxys; Nokami, Junzo; Matsuura, Hiroyuki; Nakasima, Koichi; Shibata, Satoshi; Chemistry Letters; nb. 6; (1994); p. 1071 - 1074, View in Reaxys; Rodriguez, Juan B.; Marquez, Victor E.; Nicklaus, Marc C.; Mitsuya, Hiroaki; Barchi, Joseph J.; Journal of Medicinal Chemistry; vol. 37; nb. 20; (1994); p. 3389 - 3399, View in Reaxys 10 of 37

Comment (Pharmacological Data)

Bioactivities present

Werner, H.; Hofmann, L.; Feser, R.; Paul, W.; Journal of Organometallic Chemistry; vol. 281; (1985); p. 317 - 348, View in Reaxys; Hofmann, L.; Werner, H.; Journal of Organometallic Chemistry; vol. 289; (1985); p. 141 - 156, View in Reaxys; Barluenga, Jose; Concellon, Jose M.; Fernandez-Simon, Jose L.; Yus, Miguel; Journal of the Chemical Society, Chemical Communications; nb. 8; (1988); p. 536 - 537, View in Reaxys; Dziallas, M.; Hoehn, A.; Werner, H.; Journal of Organometallic Chemistry; vol. 330; (1987); p. 207 - 220, View in Reaxys; Piers; Coish; Synthesis; nb. 1; (1995); p. 47 - 55, View in Reaxys; Oppolzer; Moretti; Zhou; Helvetica Chimica Acta; vol. 77; nb. 8; (1994); p. 2363 - 2380, View in Reaxys; Newcombe; Simpkins; Journal of the Chemical Society - Series Chemical Communications; nb. 8; (1995); p. 831 - 832, View in Reaxys; Lautens, Mark; Delanghe, Patrick H. M.; Journal of the American Chemical Society; vol. 116; nb. 19; (1994); p. 8526 - 8535, View in Reaxys; Phillipps; Bailey; Bain; Borella; Buckton; Clark; Doherty; English; Fazakerley; Laing; Lane-Allman; Robinson; Sandford; Sharratt; Steeples; Stonehouse; Williamson; Journal of Medicinal Chemistry; vol. 37; nb. 22; (1994); p. 3717 - 3729, View in Reaxys; Fujiwara; Tokuyasu; Sato; Bulletin of the Chemical Society of Japan; vol. 68; nb. 1; (1995); p. 289 - 296, View in Reaxys; Ng, John S.; Przybyla, Claire A.; Liu, Chin; Yen, Joe C.; Muellner, Frank W.; Weyker, Cara L.; Tetrahedron; vol. 51; nb. 23; (1995); p. 6397 - 6410, View in Reaxys; Concellon, Jose M.; Llavona, Lujan; Bernad, Pablo L. Jr.; Tetrahedron; vol. 51; nb. 19; (1995); p. 5573 - 5584, View in Reaxys; Aggarwal, Varinder K.; Abdel-Rahman, Hesham; Thompson, Alison; Mattison, Beverley; Jones, Ray V. H.; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 96; nb. 1-4; (1994); p. 283 - 292, View in Reaxys; Charette, Andre B.; Lebel, Helene; Journal of Organic Chemistry; vol. 60; nb. 10; (1995); p. 2966 - 2967, View in Reaxys; Masaki, Akira; Tsunashima, Shigeru; Washida, Nobuaki; Journal of Physical Chemistry; vol. 99; nb. 35; (1995); p. 13126 13131, View in Reaxys; Zhao; Lee; Yang; Chun; Du; Schinazi; Chu; Nucleosides and Nucleotides; vol. 14; nb. 3-5; (1995); p. 303 - 305, View in Reaxys; Zhou; Liu; Kiss; Sloan; White; Journal of the American Chemical Society; vol. 117; nb. 12; (1995); p. 3565 - 3592, View in Reaxys; Phillips, David Lee; Kwok, Wai Ming; Chemical Physics Letters; vol. 241; nb. 4; (1995); p. 267 - 274, View in Reaxys; Zhao; Yang; Lee; Newton; Chu; Journal of Organic Chemistry; vol. 60; nb. 16; (1995); p. 5236 - 5242, View in Reaxys; Prager, Rolf H.; Schafer, Karl; Hamon, David P. G.; Massy-Westropp, Ralph A.; Tetrahedron; vol. 51; nb. 42; (1995); p. 11465 - 11472, View in Reaxys 11 of 37

Comment (Pharmacological Data)

Bioactivities present

Hatanaka; Ishida; Tanaka; Ueda; Tetrahedron Letters; vol. 37; nb. 3; (1996); p. 401 - 404, View in Reaxys; Boehm; Zhang; Zhi; McClurg; Berger; Wagoner; Mais; Suto; Davies; Heyman; Nadzan; Journal of Medicinal Chemistry; vol. 38; nb. 16; (1995); p. 3146 - 3155, View in Reaxys; Kabat; Kiegiel; Cohen; Toth; Wovkulich; Uskokovic; Journal of Organic Chemistry; vol. 61; nb. 1; (1996); p. 118 - 124, View in Reaxys; Siddiqui; Ford Jr.; George; Marquez; Nucleosides and Nucleotides; vol. 15; nb. 1-3; (1996); p. 235 - 250, View in Reaxys; Charette, Andre B.; Cote, Bernard; Journal of the American Chemical Society; vol. 117; nb. 51; (1995); p. 12721 - 12732, View in Reaxys; Barluenga, Jose; Baragana, Beatriz; Concellon, Jose M.; Journal of Organic Chemistry; vol. 60; nb. 21; (1995); p. 6696 - 6699, View in Reaxys; Lautens, Mark; Ren, Yi; Journal of Organic Chemistry; vol. 61; nb. 6; (1996); p. 2210 - 2214, View in Reaxys; Ramon, Fabienne; Degueil-Castaing, Marie; Maillard, Bernard; Journal of Organic Chemistry; vol. 61; nb. 6; (1996); p. 2071 - 2074, View in Reaxys; Boryczka, Stanislaw; Rudnik, Magdalena; Maslankiewicz, Andrzej; Journal of Heterocyclic Chemistry; vol. 33; nb. 1; (1996); p. 145 - 149, View in Reaxys; Hamann, Lawrence G.; Farmer, Luc J.; Johnson, Michael G.; Bender, Steven L.; Mais, Dale E.; Wang, Ming-Wei; Crombie, Diane; Goldman, Mark E.; Jones, Todd K.; Journal of Medicinal Chemistry; vol. 39; nb. 9; (1996); p. 1778 - 1789, View in Reaxys; Kwok, Wai Ming; Phillips, David Lee; Journal of Chemical Physics; vol. 104; nb. 24; (1996); p. 9816 - 9832, View in Reaxys; Tietze, Lutz F.; Raschke, Thomas; Liebigs Annales; nb. 12; (1996); p. 1981 - 1987, View in Reaxys; Charette, Andre B.; Juteau, Helene; Lebel, Helene; Deschenes, Denis; Tetrahedron Letters; vol. 37; nb. 44; (1996); p. 7925 - 7928, View in Reaxys; Winkler, Jeffrey D.; Bhattacharya, Samit K.; Batey, Robert A.; Tetrahedron Letters; vol. 37; nb. 45; (1996); p. 8069 - 8072, View in Reaxys; Rigby, James H.; Sugathapala, Priyantha; Tetrahedron Letters; vol. 37; nb. 30; (1996); p. 5293 - 5296, View in Reaxys; Sibi, Mukund P.; Ji, Jianguo; Angewandte Chemie (International Edition in English); vol. 36; nb. 3; (1997); p. 274 276, View in Reaxys; Chen, Ping; Cheng, Peter T. W.; Spergel, Steven H.; Zahler, Robert; Wang, Xuebao; Thottathil, John; Barrish, Joel C.; Polniaszek, Richard P.; Tetrahedron Letters; vol. 38; nb. 18; (1997); p. 3175 - 3178, View in Reaxys; Fernandez-Megia, Eduardo; Sardina, F. Javier; Tetrahedron Letters; vol. 38; nb. 4; (1997); p. 673 - 676, View in Reaxys; Aladzheva, Inga M.; Bykhovskaya, Olga V.; Lobanov, Dmitrii I.; Petrovskii, Pavel V.; Antipin, Michael Yu.; et al.; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 111; (1996); p. 116, View in Reaxys; Seneci, Pierfausto; Caspani, Marco; Monti, Federica; Carrano, Lucia; Lociuro, Sergio; Ciabatti, Romeo; Synthetic Communications; vol. 27; nb. 5; (1997); p. 795 - 809, View in Reaxys 12 of 37

Comment (Pharmacological Data)

Bioactivities present

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2016-09-13 04:23:05

Murase, Noriaki; Maruoka, Keiji; Ooi, Takashi; Yamamoto, Hisashi; Bulletin of the Chemical Society of Japan; vol. 70; nb. 3; (1997); p. 707 - 711, View in Reaxys; Groesbeek, Michel; Smith, Steven O.; Journal of Organic Chemistry; vol. 62; nb. 11; (1997); p. 3638 - 3641, View in Reaxys; Rattigan, Oliver V.; Shallcross, Dudley E.; Cox, R. Anthony; Journal of the Chemical Society - Faraday Transactions; vol. 93; nb. 16; (1997); p. 2839 - 2846, View in Reaxys; Skorobogatov; Dymov; Nedozrelova; Russian Journal of General Chemistry; vol. 66; nb. 11; (1996); p. 1786 - 1792, View in Reaxys; Fernandez-Megia, Eduardo; Iglesias-Pintos, Jose M.; Sardina, F. Javier; Journal of Organic Chemistry; vol. 62; nb. 14; (1997); p. 4770 - 4779, View in Reaxys; Farmer, Luc J.; Jeong, Susan; Kallel, E. Adam; Canan Koch, Stacie S.; Croston, Glenn E.; Flatten, Karen S.; Heyman, Rich A.; Nadzan, Alex M.; Bioorganic and Medicinal Chemistry Letters; vol. 7; nb. 18; (1997); p. 2393 - 2398, View in Reaxys; Aggarwal, Varinder K.; Ali, Amjad; Coogan, Michael P.; Journal of Organic Chemistry; vol. 62; nb. 25; (1997); p. 8628 8629, View in Reaxys; Dyker, Gerald; Koerning, Jutta; Bubenitschek, Peter; Jones, Peter G.; Journal of Chemical Research, Miniprint; nb. 4; (1997); p. 880 - 894, View in Reaxys; Yamada, Satoshi; Nagashima, Shigeru; Takaoka, Yumiko; Torihara, Satsuki; Tanaka, Masakazu; Suemune, Hiroshi; Aso, Mariko; Journal of the Chemical Society - Perkin Transactions 1; nb. 7; (1998); p. 1269 - 1274, View in Reaxys; Barriault, Louis; Deslongchamps, Pierre; Bulletin de la Societe Chimique de France; vol. 134; nb. 10,11; (1997); p. 969 - 980, View in Reaxys; Piers, Edward; Boulet, Serge L.; Tetrahedron Letters; vol. 38; nb. 51; (1997); p. 8815 - 8818, View in Reaxys; Farmer, Luc J.; Lin, Zhi; Jeong, Susan; Kallel, E. Adam; Croston, Glenn; Flatten, Karen S.; Heyman, Rich A.; Nadzan, Alex M.; Bioorganic and Medicinal Chemistry Letters; vol. 7; nb. 21; (1997); p. 2747 - 2752, View in Reaxys; Clark, Robin J. H.; Dann, Jonathan R.; Journal of Physical Chemistry A; vol. 101; nb. 11; (1997); p. 2074 - 2082, View in Reaxys; Bilde; Sehested; Nielsen; Wallington; Meagher; McIntosh; Piety; Nicovich; Wine; Journal of Physical Chemistry A; vol. 101; nb. 43; (1997); p. 8035 - 8041, View in Reaxys; Nowak, Anette; Bolte, Oliver; Schaumann, Ernst; Tetrahedron Letters; vol. 39; nb. 7; (1998); p. 529 - 532, View in Reaxys; Ainge, Simon W.; Vogel, Pierre; Tetrahedron Letters; vol. 39; nb. 23; (1998); p. 4039 - 4042, View in Reaxys; Guindon, Yvan; Rancourt; Journal of Organic Chemistry; vol. 63; nb. 19; (1998); p. 6554 - 6565, View in Reaxys; Kaku, Yumiko; Tsuruoka, Akihiko; Kakinuma, Hiroyuki; Tsukada, Itaru; Yanagisawa, Manabu; Naito, Toshihiko; Chemical and Pharmaceutical Bulletin; vol. 46; nb. 7; (1998); p. 1125 - 1129, View in Reaxys; Soler, Tatiana; Bachki, Abderrazak; Falvello, Larry R.; Foubelo, Francisco; Yus, Miguel; Tetrahedron Asymmetry; vol. 9; nb. 22; (1998); p. 3939 - 3943, View in Reaxys; Highton, Adrian J.; Majid, Tahir N.; Simpkins, Nigel S.; Synlett; nb. 2; (1999); p. 237 239, View in Reaxys 13 of 37

Comment (Pharmacological Data)

Bioactivities present

Jay, K.; Stieglitz, L.; Chemosphere; vol. 30; nb. 7; (1995); p. 1249 - 1260, View in Reaxys; Molander, Gary A.; Shakya, Sagar R.; Journal of Organic Chemistry; vol. 61; nb. 17; (1996); p. 5885 - 5894, View in Reaxys; Cossy, Janine; Blanchard, Nicolas; Meyer, Christophe; Journal of Organic Chemistry; vol. 63; nb. 17; (1998); p. 5728 5729, View in Reaxys; Schall, C.; Laturnus, F.; Heumann, K. G.; Chemosphere; vol. 28; nb. 7; (1994); p. 1315 1324, View in Reaxys; Laturnus; Chemosphere; vol. 31; nb. 6; (1995); p. 3387 - 3395, View in Reaxys; Moore; Geen; Tait; Chemosphere; vol. 30; nb. 6; (1995); p. 1183 - 1191, View in Reaxys; Morihira; Hara; Kawahara; Nishimori; Nakamura; Kusama; Kuwajima; Journal of the American Chemical Society; vol. 120; nb. 49; (1998); p. 12980 - 12981, View in Reaxys; Chinchilla, Rafael; Galindo, Nuria; Najera, Carmen; Synthesis; nb. 4; (1999); p. 704 - 717, View in Reaxys; Hirai, Go; Oguri, Hiroki; Hirama, Masahiro; Chemistry Letters; nb. 2; (1999); p. 141 142, View in Reaxys; Gerber, Patrick; Vogel, Pierre; Tetrahedron Letters; vol. 40; nb. 16; (1999); p. 3165 - 3168, View in Reaxys; Luk'yanov; Smirnov; Nikitin; Russian Chemical Bulletin; vol. 47; nb. 11; (1998); p. 2197 - 2200, View in Reaxys; Barluenga, Jose; Baragana, Beatriz; Concellon, Jose M.; Journal of Organic Chemistry; vol. 64; nb. 8; (1999); p. 2843 - 2846, View in Reaxys; Barnier, Jean-Pierre; Morisson, Veronique; Volle, Isabelle; Blanco, Luis; Tetrahedron Asymmetry; vol. 10; nb. 6; (1999); p. 1107 - 1117, View in Reaxys; Raeppel, Franck; Weibel, Jean-Marc; Heissler, Denis; Tetrahedron Letters; vol. 40; nb. 35; (1999); p. 6377 - 6381, View in Reaxys; Coxon, Geoffrey D.; Knobl, Stefan; Roberts, Evan; Baird, Mark S.; Al Dulayymi, Juma R.; Besra, Gurdyal S.; Brennan, Patrick J.; Minnikin, David E.; Tetrahedron Letters; vol. 40; nb. 36; (1999); p. 6689 - 6692, View in Reaxys; Vinogradova; Odinets; Artyushin; Petrovskii; Lysenko; Antipin; Mastryukova; Russian Journal of General Chemistry; vol. 68; nb. 9; (1998); p. 1368 - 1377, View in Reaxys; Cossy, Janine; Blanchard, Nicolas; Meyer, Christophe; Synthesis; nb. 6; (1999); p. 1063 - 1075, View in Reaxys; Kambanis, Kyriakos G.; Journal of Physical Chemistry A; vol. 103; nb. 17; (1999); p. 3210 - 3215, View in Reaxys; Clyne, Dean S.; Weiler, Larry; Tetrahedron; vol. 55; nb. 48; (1999); p. 13659 - 13682, View in Reaxys; Lavoie, Rico; Toro, Andras; Deslongchamps, Pierre; Tetrahedron; vol. 55; nb. 45; (1999); p. 13037 - 13050, View in Reaxys 14 of 37

Comment (Pharmacological Data)

Bioactivities present

Krise, Jeffrey P.; Zygmunt, Jan; Georg, Gunda I.; Stella, Valentino J.; Journal of Medicinal Chemistry; vol. 42; nb. 16; (1999); p. 3094 - 3100, View in Reaxys; Miller, Ross A.; Humphrey, Guy R.; Lieberman, David R.; Ceglia, Scott S.; Kennedy, Derek J.; Grabowski, Edward J. J.; Reider, Paul J.; Journal of Organic Chemistry; vol. 65; nb. 5; (2000); p. 1399 - 1406, View in Reaxys; Soler, Tatiana; Bachki, Abderrazak; Falvello, Larry R.; Foubelo, Francisco; Yus, Miguel; Tetrahedron Asymmetry; vol. 11; nb. 2; (2000); p. 493 - 517, View in Reaxys; Concellon, Jose M.; Baragana, Beatriz; Riego, Estela; Tetrahedron Letters; vol. 41; nb. 22; (2000); p. 4361 - 4362, View in Reaxys; Yang, Dan; Wong, Man-Kin; Yan, Zheng; Journal of Organic Chemistry; vol. 65; nb. 13; (2000); p. 4179 - 4184, View in Reaxys; Vinogradova, Natalya M.; Odinets, Irene L.; Artyushin, Oleg I.; Lyssenko, Konstantin A.; Petrovsky, Pavel V.; Mastryukova, Tatyana A.; Phosphorus, Sulfur and Silicon and Related Elements; vol. 144-146; (1999); p. 589 - 592, View in Reaxys; Ren, Li; Crudden, Cathleen M.; Chemical Communications (Cambridge, United Kingdom); nb. 8; (2000); p. 721 - 722, View in Reaxys; Lavoie, Rico; Ouellet, Stephane G.; Dallaire, Carol;

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2016-09-13 04:23:05

Dory, Yves L.; Toro, Andras; Deslongchamps, Pierre; Tetrahedron; vol. 56; nb. 30; (2000); p. 5509 - 5522, View in Reaxys; Malamas, Michael S.; Sredy, Janet; Gunawan, Iwan; Mihan, Brenda; Sawicki, Diane R.; Seestaller, Laura; Sullivan, Donald; Flam, Brenda R.; Journal of Medicinal Chemistry; vol. 43; nb. 5; (2000); p. 995 - 1010, View in Reaxys; Kusama, Hiroyuki; Hara, Ryoma; Kawahara, Shigeru; Nishimori, Toshiyuki; Kashima, Hajime; Nakamura, Nobuhito; Morihira, Koichiro; Kuwajima, Isao; Journal of the American Chemical Society; vol. 122; nb. 16; (2000); p. 3811 - 3820, View in Reaxys; Lee, Chang-Seok; Ryu, Eun-Jung; Ho Oh, Seong; Paek, Kyoung-Sook; Kim, Mu Yong; Youn, Hasik; Bioorganic and Medicinal Chemistry Letters; vol. 10; nb. 18; (2000); p. 2123 - 2127, View in Reaxys; Piers; Coish; Synthesis; nb. 2; (2001); p. 251 - 261, View in Reaxys; Hoffmann, Reinhard W.; Nell, Peter G.; Leo, Roland; Harms, Klaus; Chemistry - A European Journal; vol. 6; nb. 18; (2000); p. 3359 - 3365, View in Reaxys; Taghipour, Fariborz; Evans, Greg J.; Environmental Science and Technology; vol. 34; nb. 14; (2000); p. 3012 - 3017, View in Reaxys; Dreos, Renata; Felluga, Alessandro; Nardin, Giorgio; Randaccio, Lucio; Siega, Patrizia; Tauzher, Giovanni; European Journal of Inorganic Chemistry; nb. 1; (2001); p. 267 - 276, View in Reaxys; Cossy, Janine; Blanchard, Nicolas; Meyer, Christophe; European Journal of Organic Chemistry; nb. 2; (2001); p. 339 - 348, View in Reaxys; Aggarwal, Varinder K; Stenson, Rachel A.; Jones, Ray V.H.; Fieldhouse, Robin; Blacker, John; Tetrahedron Letters; vol. 42; nb. 8; (2001); p. 1587 - 1589, View in Reaxys; Luithle; Pietruszka; Journal of Organic Chemistry; vol. 65; nb. 26; (2000); p. 9194 - 9200, View in Reaxys; Takimiya, Kazuo; Kataoka, Yoshiro; Aso, Yoshio; Otsubo, Tetsuo; Fukuoka, Hiroshi; Yamanaka, Shoji; Angewandte Chemie - International Edition; vol. 40; nb. 6; (2001); p. 1122 - 1125, View in Reaxys; Hutchings, Martin; Moffat, David; Simpkins, Nigel S.; Synlett; nb. 5; (2001); p. 661 - 663, View in Reaxys 15 of 37

Comment (Pharmacological Data)

Bioactivities present

Bieber, Lothar W.; De Sa, Ana C.P.F.; Menezes, Paulo H.; Goncalves, Simone M.C.; Tetrahedron Letters; vol. 42; nb. 28; (2001); p. 4597 - 4599, View in Reaxys; Iorga, Bogdan; Savignac, Philippe; Journal of Organometallic Chemistry; vol. 624; nb. 1-2; (2001); p. 203 - 207, View in Reaxys; Cordi; Berque-Bestel; Persigand; Lacoste; Newman-Tancredi; Audinot; Millan; Journal of Medicinal Chemistry; vol. 44; nb. 5; (2001); p. 787 - 805, View in Reaxys; Gerber, Patrick; Vogel, Pierre; Helvetica Chimica Acta; vol. 84; nb. 6; (2001); p. 1363 - 1395, View in Reaxys; Yamamoto, Hideki; Yokouchi, Yoko; Otsuki, Akira; Itoh, Hiroyasu; Chemosphere; vol. 45; nb. 3; (2001); p. 371 - 377, View in Reaxys; Murray, Anthony; Hansen, John Bondo; Christensen, Birgitte V; Tetrahedron; vol. 57; nb. 34; (2001); p. 7383 - 7390, View in Reaxys; Faul; Ratz; Sullivan; Trankle; Winneroski; Journal of Organic Chemistry; vol. 66; nb. 17; (2001); p. 5772 - 5782, View in Reaxys; Kwok, Wai Ming; Ma, Chensheng; Parker, Anthony W.; Phillips, David; Towrie, Michael; Matousek, Pavel; Zheng, Xuming; Phillips, David Lee; Journal of Chemical Physics; vol. 114; nb. 17; (2001); p. 7536 - 7543, View in Reaxys; Wheeler; Stourman; Thier; Dommermuth; Vuilleumier; Rose; Armstrong; Guengerich; Chemical Research in Toxicology; vol. 14; nb. 8; (2001); p. 1118 - 1127, View in Reaxys; Concellon; Riego; Rodriguez-Solla; Plutin; Journal of Organic Chemistry; vol. 66; nb. 25; (2001); p. 8661 - 8665, View in Reaxys; Lautens, Mark; Maddess, Matthew L.; Sauer, Effiette L. O.; Ouellet, Stephane G.; Organic Letters; vol. 4; nb. 1; (2002); p. 83 - 86, View in Reaxys; Raab, Conrad E.; Dean, Dennis C.; Melillo, David G.; Journal of Labelled Compounds and Radiopharmaceuticals; vol. 44; nb. 12; (2001); p. 815 - 829, View in Reaxys; Myers; Barbay; Zhong; Journal of the American Chemical Society; vol. 123; nb. 30; (2001); p. 7207 - 7219, View in Reaxys; Aggarwal, Varinder K.; Coogan, Michael P.; Stenson, Rachel A.; Jones, Raymond V. H.; Fieldhouse, Robin; Blacker, John; European Journal of Organic Chemistry; nb. 2; (2002); p. 319 - 326, View in Reaxys; Dean, Kathryn E.S.; Kirby, Anthony J.; Journal of the Chemical Society, Perkin Transactions 2; nb. 3; (2002); p. 428 - 432, View in Reaxys; Vendeville, Sandrine; Goossens, Filip; Debreu-Fontaine, Marie-Ange; Landry, Valerie; Davioud-Charvet, Elisabeth; Grellier, Philippe; Scharpe, Simon; Sergheraert, Christian; Bioorganic and Medicinal Chemistry; vol. 10; nb. 6; (2002); p. 1719 - 1729, View in Reaxys; Aruna; Vijayalakshmi; Valera; Setser; Physical Chemistry Chemical Physics; vol. 4; nb. 1; (2002); p. 51 - 59, View in Reaxys; Friestad; Qin; Journal of the American Chemical Society; vol. 123; nb. 40; (2001); p. 9922 - 9923, View in Reaxys; Concellon, Jose M.; Rodriguez-Solla, Humberto; Huerta, Monica; Perez-Andres, Juan A.; European Journal of Organic Chemistry; nb. 11; (2002); p. 1839 - 1847, View in Reaxys; Cossy, Janine; Blanchard, Nicolas; Meyer, Christophe; Tetrahedron Letters; vol. 43; nb. 10; (2002); p. 1801 - 1805, View in Reaxys 16 of 37

Comment (Pharmacological Data)

Bioactivities present

Paradisi, Francesca; Porzi, Gianni; Sandri, Sergio; Tetrahedron Asymmetry; vol. 12; nb. 23; (2001); p. 3319 3324, View in Reaxys; Maligres, Peter E.; Waters, Marjorie M.; Lee, Jaemoon; Reamer, Robert A.; Askin, David; Ashwood, Michael S.; Cameron, Mark; Journal of Organic Chemistry; vol. 67; nb. 4; (2002); p. 1093 - 1101, View in Reaxys; Sibi, Mukund P.; Liu, Pingrong; Ji, Jianguo; Hajra, Saumen; Chen, Jian-Xie; Journal of Organic Chemistry; vol. 67; nb. 6; (2002); p. 1738 - 1745, View in Reaxys; Senapati, Dulal; Kavita; Das, Puspendu K.; Journal of Physical Chemistry A; vol. 106; nb. 36; (2002); p. 8479 - 8482, View in Reaxys; Kedrowski, Brant L.; Heathcock, Clayton H.; Heterocycles; vol. 58; (2002); p. 601 - 634, View in Reaxys; Gerber-Lemaire, Sandrine; Ainge, Simon W.; Glanzmann, Cecile; Vogel, Pierre; Helvetica Chimica Acta; vol. 85; nb. 2; (2002); p. 417 - 430, View in Reaxys; Nadin, Alan; Owens, Andrew P.; Castro, Jose L.; Harrison, Timothy; Shearman, Mark S.; Bioorganic and Medicinal Chemistry Letters; vol. 13; nb. 1; (2003); p. 37 - 41, View in Reaxys; Farmer, Luc J; Zhi, Lin; Jeong, Susan; Lamph, William W; Osburn, Deborah L; Croston, Glenn; Flatten, Karen S; Heyman, Rich A; Nadzan, Alex M; Bioorganic and medicinal chemistry letters; vol. 13; nb. 2; (2003); p. 261 - 264, View in Reaxys; Tian, Shan Xi; Kishimoto, Naoki; Ohno, Koichi; Journal of Physical Chemistry A; vol. 107; nb. 4; (2003); p. 485 493, View in Reaxys; Mendes, Christelle; Renard, Sylvie; Rofoo, Mazin; Roux, Marie-Claude; Rousseau, Gerard; European Journal of Organic Chemistry; nb. 3; (2003); p. 463 - 471, View in Reaxys; Coxon, Geoffrey D.; AlDulayymi, Juma R.; Baird, Mark S.; Knobl, Stefan; Roberts, Evan; Minnikin, David E.; Tetrahedron Asymmetry; vol. 14; nb. 9; (2003); p. 1211 - 1222, View in Reaxys; Takai, Kazuhiko; Ueda, Takashi; Ikeda, Norihiko; Ishiya-

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Comment (Pharmacological Data)

Bioactivities present

Coxon, Geoffrey D.; Al Dulayymi, Juma'a R.; Morehouse, Caroline; Brennan, Patrick J.; Besra, Gurdyal S.; Baird, Mark S.; Minnikin, David E.; Chemistry and Physics of Lipids; vol. 127; nb. 1; (2004); p. 35 - 46, View in Reaxys; Hirai, Go; Oguri, Hiroki; Hayashi, Masahiko; Koyama, Koji; Koizumi, Yuuki; Moharram, Sameh M.; Hirama, Masahiro; Bioorganic and Medicinal Chemistry Letters; vol. 14; nb. 10; (2004); p. 2647 - 2651, View in Reaxys; Breitfelder, Steffen; Schuemacher, Anne C.; Roelle, Thomas; Kikuchi, Makoto; Hoffmann, Reinhard W.; Helvetica Chimica Acta; vol. 87; nb. 5; (2004); p. 1202 - 1213, View in Reaxys; Laroche, MarieFrance; Belotti, Damien; Cossy, Janine; Organic Letters; vol. 7; nb. 2; (2005); p. 171 - 173, View in Reaxys; Stulgies, Baldur; Pigg Jr., Dennis P.; Kaszynski, Piotr; Kudzin, Zbigniew H.; Tetrahedron; vol. 61; nb. 1; (2005); p. 89 - 95, View in Reaxys; Chun, Jiong; Yin, Ye Ingrid; Yang, Guangli; Tarassishin, Leonid; Li, Yue-Ming; Journal of Organic Chemistry; vol. 69; nb. 21; (2004); p. 7344 - 7347, View in Reaxys; Burrell, Richard C.; Lago, Michael W.; Luke, George M.; Rinehart, J. Kent; Journal of Labelled Compounds and Radiopharmaceuticals; vol. 48; nb. 2; (2005); p. 123 - 130, View in Reaxys; Bellenie, Benjamin R.; Goodman, Jonathan M.; Chemical Communications; nb. 9; (2004); p. 1076 - 1077, View in Reaxys; Enami, Shinichi; Ueda, Junya; Goto, Masashi; Nakano, Yukio; Aloisio, Simone; Hashimoto, Satoshi; Kawasaki, Masahiro; Journal of Physical Chemistry A; vol. 108; nb. 30; (2004); p. 6347 - 6350, View in Reaxys; Dieltiens, Nicolai; Stevens, Christian V.; Masschelein, Kurt G. R.; Rammeloo, Thomas; Tetrahedron; vol. 61; nb. 28; (2005); p. 6749 - 6756, View in Reaxys; Maddess, Matthew L.; Lautens, Mark; Organic Letters; vol. 7; nb. 16; (2005); p. 3557 - 3560, View in Reaxys; Yajima, Tomoko; Saito, Chiaki; Nagano, Hajime; Tetrahedron; vol. 61; nb. 43; (2005); p. 10203 - 10215, View in Reaxys; Lukeman, Matthew; Scaiano, Juan C.; Journal of the American Chemical Society; vol. 127; nb. 21; (2005); p. 7698 - 7699, View in Reaxys; Miller, John F.; Brieger, Michael; Furfine, Eric S.; Hazen, Richard J.; Kaldor, Istvan; Reynolds, David; Sherrill, Ronald G.; Spaltenstein, Andrew; Bioorganic and Medicinal Chemistry Letters; vol. 15; nb. 15; (2005); p. 3496 - 3500, View in Reaxys; Gu, Haining; Xu, Wei Ming; Kinstle, Thomas H.; Tetrahedron Letters; vol. 46; nb. 38; (2005); p. 6449 - 6451, View in Reaxys; Lebrun, Marie-Eve; Le Marquand, Paul; Berthelette, Carl; Journal of Organic Chemistry; vol. 71; nb. 5; (2006); p. 2009 - 2013, View in Reaxys; Smith III, Amos B.; Xian, Ming; Liu, Fenghua; Organic Letters; vol. 7; nb. 21; (2005); p. 4613 - 4616, View in Reaxys; Friestad, Gregory K.; Draghici, Cristian; Soukri, Mustapha; Qin, Jun; Journal of Organic Chemistry; vol. 70; nb. 16; (2005); p. 6330 6338, View in Reaxys; Mazitschek, Ralph; Huwe, Axel; Giannis, Athanassios; Organic and Biomolecular Chemistry; vol. 3; nb. 11; (2005); p. 2150 - 2154, View in Reaxys; Hoffmann; Brueckner; New Journal of Chemistry; vol. 25; nb. 3; (2001); p. 369 - 373, View in Reaxys 18 of 37

Comment (Pharmacological Data)

Bioactivities present

Nomura, Takashi; Yasukata, Tatsuro; Narukawa, Yukitoshi; Uotani, Kouichi; Bioorganic and Medicinal Chemistry; vol. 13; nb. 21; (2005); p. 6054 - 6063, View in Reaxys; Lin, Xufeng; Guan, Xiangguo; Kwok, Wai Ming; Zhao, Cunyuan; Du, Yong; Li, Yun-Liang; Phillips, David Lee; Journal of Physical Chemistry A; vol. 109; nb. 6; (2005); p. 981 - 998, View in Reaxys; Bandur, Nina G.; Brueckner, David; Hoffmann, Reinhard W.; Koert, Ulrich; Organic Letters; vol. 8; nb. 17; (2006); p. 3829 - 3831, View in Reaxys; Barry, Conor S.; Elsworth, Jon D.; Seden, Peter T.; Bushby, Nick; Harding, John R.; Alder, Roger W.; Willis, Christine L.; Organic Letters; vol. 8; nb. 15; (2006); p. 3319 - 3322, View in Reaxys; McBriar, Mark D.; Guzik, Henry; Shapiro, Sherry; Paruchova, Jaroslava; Xu, Ruo; Palani, Anandan; Clader, John W.; Cox, Kathleen; Greenlee, William J.; Hawes, Brian E.; Kowalski, Timothy J.; O'Neill, Kim; Spar, Brian D.; Weig, Blair; Weston, Daniel J.; Farley, Constance; Cook, John; Journal of Medicinal Chemistry; vol. 49; nb. 7; (2006); p. 2294 - 2310, View in Reaxys; McBriar, Mark D.; Guzik, Henry; Shapiro, Sherry; Xu, Ruo; Paruchova, Jaroslava; Clader, John W.; O'Neill, Kim; Hawes, Brian; Sorota, Steve; Margulis, Michael; Tucker, Kristal; Weston, Daniel J.; Cox, Kathleen; Bioorganic and Medicinal Chemistry Letters; vol. 16; nb. 16; (2006); p. 4262 - 4265, View in Reaxys; Dreos, Renata; Mechi, Lassaad; Randaccio, Lucio; Siega, Patrizia; Zangrando, Ennio; Hassen, Rached Ben; Journal of Organometallic Chemistry; vol. 691; nb. 15; (2006); p. 3305 - 3309, View in Reaxys; Friestad, Gregory K.; Marie, Jean-Charles; Suh, YoungSung; Qin, Jun; Journal of Organic Chemistry; vol. 71; nb. 18; (2006); p. 7016 - 7027, View in Reaxys; Savoia, Diego; Alvaro, Giuseppe; Di Fabio, Romano; Gualandi, Andrea; Fiorelli, Claudio; Journal of Organic Chemistry; vol. 71; nb. 25; (2006); p. 9373 - 9381, View in Reaxys; Rogers, Evan W.; Molinski, Tadeusz F.; Organic Letters; vol. 9; nb. 3; (2007); p. 437 - 440, View in Reaxys; Nicolaou; Harrison, Scott T.; Journal of the American Chemical Society; vol. 129; nb. 2; (2007); p. 429 - 440, View in Reaxys; Rogers, Erik; Araki, Hiroshi; Batory, Lindsay A.; McInnis, Christine E.; Njardarson, Jon T.; Journal of the American Chemical Society; vol. 129; nb. 10; (2007); p. 2768 -

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Comment (Pharmacological Data)

Bioactivities present

Concellon, Jose M.; Rodriguez-Solla, Humberto; Mejica, Carmen; Blanco, Elena G.; Organic Letters; vol. 9; nb. 16; (2007); p. 2981 - 2984, View in Reaxys; Korapala, Chandra Sekhar; Qin, Jun; Friestad, Gregory K.; Organic Letters; vol. 9; nb. 21; (2007); p. 4243 - 4246, View in Reaxys; Lira, Ricardo; Roush, William R.; Organic Letters; vol. 9; nb. 21; (2007); p. 4315 - 4318, View in Reaxys; Song, Zhenlei; Lu, Ting; Hsung, Richard P.; Al-Rashid, Ziyad F.; Ko, Changhong; Tang, Yu; Angewandte Chemie - International Edition; vol. 46; nb. 22; (2007); p. 4069 4072, View in Reaxys; Su, Jing; Tang, Haiqun; McKittrick, Brian A.; Gu, Huizhong; Guo, Tao; Qian, Gang; Burnett, Duane A.; Clader, John W.; Greenlee, William J.; Hawes, Brian E.; O'Neill, Kim; Spar, Brian; Weig, Blair; Kowalski, Timothy; Sorota, Steve; Bioorganic and Medicinal Chemistry Letters; vol. 17; nb. 17; (2007); p. 4845 4850, View in Reaxys; Trost, Barry M.; Hu, Yimin; Horne, Daniel B.; Journal of the American Chemical Society; vol. 129; nb. 38; (2007); p. 11781 - 11790, View in Reaxys; Haak, Robert M.; Tarabiono, Chiara; Janssen, Dick B.; Minnaard, Adriaan J.; De Vries, Johannes G.; Feringa, Ben L.; Organic and Biomolecular Chemistry; vol. 5; nb. 2; (2007); p. 318 - 323, View in Reaxys; Patent; Glaxo Laboratories Limited; US3981894; (1976); (A1) English, View in Reaxys; Patent; Leo Pharmaceutical Products Ltd. A/S; US4181659; (1980); (A1) English, View in Reaxys; Patent; Lovens Kemiske Fabrik Produktionsaktieselskab; US3951957; (1976); (A1) English, View in Reaxys; Patent; Pfizer Inc.; US4381263; (1983); (A1) English, View in Reaxys; Patent; Pfizer Inc.; US4530792; (1985); (A1) English, View in Reaxys; Patent; Pfizer, Inc.; US4457924; (1984); (A1) English, View in Reaxys; Patent; G.D. Searle and Co.; US5776971; (1998); (A1) English, View in Reaxys; Patent; Meerpoel, Lieven; Heeres, Jan; Odds, Frank Christopher; Vanden Bossche, Hugo Florent Adolf; Van der Veken, Louis Jozef Elisabeth; US6387906; (2002); (B1) English, View in Reaxys; Patent; ABBOTT LABORATORIES; WO2004/869; (2003); (A1) English, View in Reaxys; Patent; Kissei Pharmaceutical Co., Ltd.; EP1364957; (2003); (A1) English, View in Reaxys; Patent; Soft Drugs, Inc.; EP902789; (2002); (B1) English, View in Reaxys; Patent; GLAXO GROUP LIMITED; WO2006/50940; (2006); (A1) English, View in Reaxys; Davies, Stephen G.; Ling, Kenneth B.; Roberts, Paul M.; Russell, Angela J.; Thomson, James E.; Chemical Communications; nb. 39; (2007); p. 4029 - 4031, View in Reaxys 20 of 37

Comment (Pharmacological Data)

Bioactivities present

Simpkins, Ligaya M.; Bolton, Scott; Pi, Zulan; Sutton, James C.; Kwon, Chet; Zhao, Guohua; Magnin, David R.; Augeri, David J.; Gungor, Timur; Rotella, David P.; Sun, Zhong; Liu, Yajun; Slusarchyk, William S.; Marcinkeviciene, Jovita; Robertson, James G.; Wang, Aiying; Robl, Jeffrey A.; Atwal, Karnail S.; Zahler, Robert L.; Parker, Rex A.; Kirby, Mark S.; Hamann, Lawrence G.; Bioorganic and Medicinal Chemistry Letters; vol. 17; nb. 23; (2007); p. 6476 - 6480, View in Reaxys; Li, Hongmei; Asberom, Theodros; Bara, Thomas A.; Clader, John W.; Greenlee, William J.; Josien, Hubert B.; McBriar, Mark D.; Nomeir, Amin; Pissarnitski, Dmitri A.; Rajagopalan, Murali; Xu, Ruo; Zhao, Zhiqiang; Song, Lixin; Zhang, Lili; Bioorganic and Medicinal Chemistry Letters; vol. 17; nb. 22; (2007); p. 6290 - 6294, View in Reaxys; Walker, Daniel P.; Acker, Brad A.; Jacobsen, E. Jon; Wishka, Donn G.; Journal of Heterocyclic Chemistry; vol. 45; nb. 1; (2008); p. 247 - 257, View in Reaxys; Koyama, Yasuhito; Yamaguchi, Ryo; Suzuki, Keisuke; Angewandte Chemie - International Edition; vol. 47; nb. 6; (2008); p. 1084 - 1087, View in Reaxys; Workman, David P.; Quintana, William; Shore, Sheldron G.; Acta Crystallographica, Section C: Crystal Structure Communications; vol. 47; (1991); p. 6 - 8, View in Reaxys; vol. Co: Org.Verb.1; 1.5.1.1.6.3, page 323 - 340, View in Reaxys; Bennett, Martin A.; Crisp, Geoffrey T.; Australian Journal of Chemistry; vol. 39; (1986); p. 1363 - 1376, View in Reaxys; Galamb, Vilmos; Palyi, Gyula; Boese, Roland; Schmid, Guenter; Organometallics; vol. 6; (1987); p. 861 - 867, View in Reaxys; Monaghan, Patrick K.; Puddephatt, Richard J.; Organometallics; vol. 4; (1985); p. 1406 - 1412, View in Reaxys; Sadhu, Kizhakethil Mathew; Matteson, Donald S.; Organometallics; vol. 4; (1985); p. 1687 - 1689, View in Reaxys; Werner, Helmut; Hofmann, Lothar; Ziegler, Manfred L.; Zahn, Thomas; Organometallics; vol. 5; (1986); p. 510 - 513, View in Reaxys; Moss, John R.; Niven, Margaret L.; Stretch, Phillippa M.; Inorganica Chimica Acta; vol. 119; (1986); p. 177 - 186, View in Reaxys; Murray, H. H.; Fackler, John P.; Mazany, Anthony M.; Organometallics; vol. 3; (1984); p. 1310 - 1311, View in Reaxys; Dreos; Felluga; Nardin; Randaccio; Siega; Tauzher; Inorganic Chemistry; vol. 40; nb. 22; (2001); p. 5541 - 5546, View in Reaxys; Dreos, Renata; Felluga, Alessandro; Nardin, Giorgio; Randaccio, Lucio; Sandri, Mauro; Tauzher, Giovanni; Inorganic Chemistry; vol. 41; nb. 17; (2002); p. 4548 - 4554, View in Reaxys; Dreos, Renata; Nardin, Giorgio; Randaccio, Lucio; Siega, Patrizia; Tauzher, Giovanni; Vrdoljak, Visnia; Inor-

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Comment (Pharmacological Data)

Bioactivities present

Patent; Betschart, Claudia; Lerchner, Andreas; Machauer, Rainer; Rueger, Heinrich; Tintelnot-Blomley, Marina; Veenstra, Siem Jacob; US2008/132477; (2008); (A1) English, View in Reaxys; Patent; NOVARTIS AG; WO2008/62044; (2008); (A1) English, View in Reaxys; Patent; NEUROGESX, INC.; WO2008/70149; (2008); (A2) English, View in Reaxys; Patent; Glaxo Group Limited; US2008/194547; (2008); (A1) English, View in Reaxys; Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2008/42925; (2008); (A1) English, View in Reaxys; Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2005/48932; (2005); (A2) English, View in Reaxys; Richardson, Susan D.; Thruston Jr., Alfred D.; Krasner, Stuart W.; Weinberg, Howard S.; Miltner, Richard J.; Schenck, Kathleen M.; Narotsky, Michael G.; McKague, A. Bruce; Simmons, Jane Ellen; Journal of Toxicology and Environmental Health - Part A: Current Issues; vol. 71; nb. 17; (2008); p. 1165 - 1186, View in Reaxys; McBriar, Mark D.; Clader, John W.; Chu, Inhou; Del Vecchio, Robert A.; Favreau, Leonard; Greenlee, William J.; Hyde, Lynn A.; Nomeir, Amin A.; Parker, Eric M.; Pissarnitski, Dmitri A.; Song, Lixin; Zhang, Lili; Zhao, Zhiqiang; Bioorganic and Medicinal Chemistry Letters; vol. 18; nb. 1; (2008); p. 215 - 219, View in Reaxys; Park, Heuisul; Min, Kyeongsik; Kwak, Hyo-Shin; Koo, Ki Dong; Lim, Dongchul; Seo, Sang-Won; Choi, Jae-Ung; Platt, Bettina; Choi, Deog-Young; Bioorganic and Medicinal Chemistry Letters; vol. 18; nb. 9; (2008); p. 2900 - 2904, View in Reaxys; Patent; INTERMUNE, INC.; ARRAY BIOPHARMA, INC.; WO2008/137779; (2008); (A2) English, View in Reaxys; Patent; AMGEN INC.; WO2008/147544; (2008); (A1) English, View in Reaxys; Patent; AMGEN INC.; WO2008/147547; (2008); (A1) English, View in Reaxys; Haak, Robert M.; Berthiol, Florian; Jerphagnon, Thomas; Gayet, Arnaud J. A.; Tarabiono, Chiara; Postema, Christiaan P.; Ritleng, Vincent; Pfeffer, Michel; Janssen, Dick B.; Minnaard, Adriaan J.; Feringa, Ben L.; De Vries, Johannes G.; Journal of the American Chemical Society; vol. 130; nb. 41; (2008); p. 13508 - 13509, View in Reaxys; Patent; Aebi, Johannes; Binggeli, Alfred; Green, Luke; Hartmann, Guido; Maerki, Hans P.; Mattei, Patrizio; Ricklin, Fabienne; US2009/23713; (2009); (A1) English, View in Reaxys; Patent; AMGEN INC.; WO2009/9122; (2009); (A2) English, View in Reaxys; Hohn, Erwin; Palecek, Jiri; Pietruszka, Joerg; Synlett; nb. 7; (2008); p. 971 - 974, View in Reaxys; Blakemore, Paul R.; Milicevic, Selena D.; Perera, Hasini; Shvarev, Alexey; Zakharov, Lev N.; Synthesis; nb. 14 SPEC. ISS.; (2008); p. 2271 - 2277; Art.No: C01408SS, View in Reaxys; Seden, Peter T.; Charmant, Jonathan P. H.; Willis, Christine L.; Organic Letters; vol. 10; nb. 8; (2008); p. 1637 - 1640, View in Reaxys; Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; WO2009/18656; (2009); (A1) English, View in Reaxys; Patent; LG LIFE SCIENCES, LTD.; WO2009/38411; (2009); (A2) English, View in Reaxys 22 of 37

Comment (Pharmacological Data)

Bioactivities present

Patent; LG LIFE SCIENCES, LTD.; WO2009/38412; (2009); (A2) English, View in Reaxys; Patent; Daiichi Sankyo Company, Limited; EP2048150; (2009); (A1) English, View in Reaxys; Patent; ARRAY BIOPHARMA INC.; WO2009/42435; (2009); (A1) English, View in Reaxys; Patent; SMITHKLINE BEECHAM CORPORATION; ANACOR PHARMACEUTICALS, INC.; WO2009/46098; (2009); (A1) English, View in Reaxys; Brichacek, Matthew; Lee, Dongeun; Njardarson, Jon T.; Organic Letters; vol. 10; nb. 21; (2008); p. 5023 - 5026, View in Reaxys; Bull, James A.; Mousseau, James J.; Charette, Andre B.; Organic Letters; vol. 10; nb. 23; (2008); p. 5484 - 5488, View in Reaxys; Vedrenne, Emeline; Wallner, Olov A.; Vitale, Maxime; Schmidt, Frank; Aggarwal, Varinder K.; Organic Letters; vol. 11; nb. 1; (2009); p. 165 - 168, View in Reaxys; Patent; Eisai RandD Management Co., Ltd.; EP2062901; (2009); (A1) English, View in Reaxys; Patent; PROTEZ PHARMACEUTICALS, INC.; WO2009/64413; (2009); (A1) English, View in Reaxys; Patent; ABBOTT LABORATORIES; WO2009/67613; (2009); (A1) English, View in Reaxys; Concellon, Jose M.; Rodriguez-Solla, Humberto; Bernad, Pablo L.; Simal, Carmen; Journal of Organic Chemistry; vol. 74; nb. 6; (2009); p. 2452 - 2459, View in Reaxys; Yang, Guangli; Yin, Ye Ingrid; Chun, Jiong; Shelton, Christopher C.; Ouerfelli, Ouathek; Li, Yue-Ming; Bioorganic and Medicinal Chemistry Letters; vol. 19; nb. 3; (2009); p. 922 - 925, View in Reaxys; Patent; NOVARTIS AG; WO2009/106599; (2009); (A2) English, View in Reaxys; Patent; GLAXO GROUP LIMITED; WO2009/109608; (2009); (A1) English, View in Reaxys; Lu, Ting; Hayashi, Ryuji; Hsung, Richard P.; Dekorver, Kyle A.; Lohse, Andrew G.; Song, Zhenlei; Tang, Yu; Organic and Biomolecular Chemistry; vol. 7; nb. 16; (2009); p. 3331 - 3337, View in Reaxys; Machauer, Rainer; Laumen, Kurt; Veenstra, Siem; Rondeau, Jean-Michel; Tintelnot-Blomley, Marina; Betschart, Claudia; Jaton, Anne-Lise; Desrayaud, Sandrine; Staufenbiel, Matthias; Rabe, Sabine; Paganetti, Paolo; Neumann, Ulf; Bioorganic and Medicinal Chemistry Letters; vol. 19; nb. 5; (2009); p. 1366 - 1370, View in Reaxys; Ishikawa, Minoru; Ninomiya, Tomohisa; Akabane, Hirotomo; Kushida, Nobuaki; Tsujiuchi, Go; Ohyama, Makoto; Gomi, Shuichi; Shito, Keiko; Murata, Takashi; Bioorganic and Medicinal Chemistry Letters; vol. 19; nb. 5; (2009); p. 1457 1460, View in Reaxys; Patent; Speedel Experimenta AG; US2009/275651; (2009); (A1) English, View in Reaxys; Patent; MERCK and CO., INC.; WO2009/129036; (2009); (A1) English, View in Reaxys; Dutheuil, Guillaume; Webster, Matthew P.; Aggarwal, Varinder K.; Worthington, Paul A.; Angewandte Chemie, International Edition; vol. 48; nb. 34; (2009); p. 6317 - 6319; Angewandte Chemie; vol. 121; nb. 34; (2009); p. 6435 - 6437, View in Reaxys

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Comment (Pharmacological Data)

Bioactivities present

Hohn, Erwin; Palecek, Jiri; Pietruszka, Joerg; Frey, Wolfgang; European Journal of Organic Chemistry; nb. 22; (2009); p. 3765 - 3782, View in Reaxys; Patent; MERCK and CO., INC.; WO2009/140163; (2009); (A1) English, View in Reaxys; Patent; ABBOTT LABORATORIES; US2009/312338; (2009); (A1) English, View in Reaxys; Degennaro, Leonardo; Capriati, Vito; Carlucci, Claudia; Florio, Saverio; Luisi, Renzo; Nuzzo, Irene; Cuocci, Corrado; Tetrahedron; vol. 65; nb. 42; (2009); p. 8745 - 8755, View in Reaxys; Nebot, Joaquim; Romea, Pedro; Urpi, Felix; Journal of Organic Chemistry; vol. 74; nb. 19; (2009); p. 7518 - 7521, View in Reaxys; Patent; G.D. Searle and Co.; US6337398; (2002); (B1) English, View in Reaxys; Patent; Eisai Co., Ltd.; EP1231210; (2002); (A2) English, View in Reaxys; Patent; Termin, Andreas; Grootenhuis, Peter D.J.; Wilson, Dean M.; Molteni, Valentina; Mao, Long; Castellino, Angelo; Yang, Zhicai; Pechulis, Anthony; Suto, Mark; US2003/229091; (2003); (A1) English, View in Reaxys; Patent; G.D. Searle and Co.; US2004/48934; (2004); (A1) English, View in Reaxys; Patent; Walker, Daniel Patrick; Piotrowski, David W.; Jacobsen, Eric Jon; Acker, Brad A.; Groppi JR., Vincent E.; US2003/232853; (2003); (A1) English, View in Reaxys; Patent; Rogers, Bruce N.; Piotrowski, David W.; Walker, Daniel Patrick; Jacobsen, Eric Jon; Acker, Brad A.; Wishka, Donn G.; Groppi JR., Vincent E.; US2003/236264; (2003); (A1) English, View in Reaxys; Patent; MERCK SHARP and DOHME LIMITED; WO2004/31190; (2004); (A1) English, View in Reaxys; Patent; GLAXO GROUP LIMITED; WO2004/39827; (2004); (A2) English, View in Reaxys; Patent; Jacobsen, Eric Jon; Myers, Jason K.; Walker, Daniel Patrick; Wishka, Donn G.; Reitz, Steven Charles; Piotrowski, David W.; Acker, Brad A.; Groppi JR., Vincent E.; US2003/236270; (2003); (A1) English, View in Reaxys; Patent; Nagarajan, Srinivasan R.; Khanna, Ish Kumar; Clare, Michael; Gasiecki, Alan; Rogers, Thomas; Chen, Barbara; Russell, Mark; Lu, Hwang-Fun; Yi, Yu; Huff, Renee M.; Desai, Bipinchandra N.; Devadas, Balekudru; Parikh, Mihir D.; Penning, Thomas; US2004/92538; (2004); (A1) English, View in Reaxys; Patent; PHARMACIA and UPJOHN COMPANY; WO2004/52889; (2004); (A1) English, View in Reaxys; Patent; PHARMACIA CORPORATION; WO2005/51904; (2005); (A2) English, View in Reaxys; Patent; ELAN PHARMACEUTICALS, INC.; WO2005/70407; (2005); (A1) English, View in Reaxys; Patent; Ueda, Yasutsugu; Connolly, Timothy P.; Kadow, John F.; Meanwell, Nicholas A.; Wang, Tao; Chen, Chung-Pin H.; Yeung, Kap-Sun; Zhang, Zhongxing; Leahy, David Kenneth; Pack, Shawn K.; Soundararajan, Nachimuthu; Sirard, Pierre; Levesque, Kathia; Thoraval, Dominique; US2005/209246; (2005); (A1) English, View in Reaxys; Patent; ELAN PHARMACEUTICALS, INC.; WO2005/87752; (2005); (A2) English, View in Reaxys 24 of 37

Comment (Pharmacological Data)

Bioactivities present

Patent; SCHERING CORPORATION; WO2005/97768; (2005); (A2) English, View in Reaxys; Patent; Pfizer Inc; US2005/272800; (2005); (A1) English, View in Reaxys; Patent; BIOLIPOX AB; WO2005/123673; (2005); (A1) English, View in Reaxys; Patent; John, Varghese; Hom, Roy; Sealy, Jennifer; Tucker, John; US2006/14737; (2006); (A1) English, View in Reaxys; Patent; PIERRE FABRE MEDICAMENT; US2006/14827; (2006); (A1) English, View in Reaxys; Patent; SCHERING CORPORATION; WO2006/4880; (2006); (A2) English, View in Reaxys; Patent; Adam, Jean-Michel; Aebi, Johannes; Binggeli, Alfred; Green, Luke; Hartmann, Guido; Maerki, Hans P.; Mattei, Patrizio; Ricklin, Fabienne; Roche, Olivier; US2010/22518; (2010); (A1) English, View in Reaxys; Hamada, Manabu; Inami, Yoshikazu; Nagai, Yasuhito; Higashi, Toshinori; Shoji, Mitsuru; Ogawa, Seiichiro; Umezawa, Kazuo; Sugai, Takeshi; Tetrahedron Asymmetry; vol. 20; nb. 18; (2009); p. 2105 - 2111, View in Reaxys; Nicolaou; Dong, Lin; Deng, Lujiang; Talbot, Adam C.; Chen, David Y.-K.; Chemical Communications; vol. 46; nb. 1; (2010); p. 70 - 72, View in Reaxys; Patent; BRISTOL-MYERS SQUIBB COMPANY; BELEMA, Makonen; GOOD, Andrew, C.; GOODRICH, Jason; KAKARLA, Ramesh; LI, Guo; LOPEZ, Omar, D.; NGUYEN, Van, N.; KAPUR, Jayne; QIU, Yuping; ROMINE, Jeffrey, Lee; ST. LAURENT, Denis, R.; SERRANO-WU, Michael; SNYDER, Lawrence, B.; YANG, Fukang; WO2010/17401; (2010); (A1) English, View in Reaxys; Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.; BRANCA, Danila; FERRIGNO, Federica; HERNANDO, Jose, Ignacio, Martin; JONES, Philip; KINZEL, Olaf; MALANCONA, Savina; MURAGLIA, Ester; PALUMBI, Maria, Cecilia; PESCATORE, Giovanna; SCARPELLI, Rita; WO2010/23480; (2010); (A1) English, View in Reaxys; Patent; XENON PHARMACEUTICALS, INC.; CHAFEEV, Mikhail; CHOWDHURY, Sultan; FRASER, Lauren; FU, Jianmin; LANGILLE, Jonathan; LIU, Shifeng; SUN, Jianyu; SUN, Shaoyi; SVIRIDOV, Serguei; WOOD, Mark; ZENOVA, Alla; WO2010/45197; (2010); (A1) English, View in Reaxys; Patent; XENON PHARMACEUTICALS, INC.; CHAFEEV, Mikhail; CHOWDHURY, Sultan; FRASER, Lauren; FU, Jianmin; LANGILLE, Jonathan; LIU, Shifeng; SUN, Jianyu; SUN, Shaoyi; SVIRIDOV, Serguei; WOOD, Mark; ZENOVA, Alla; JIA, Qi; CADIEUX, Jean-Jacques; GAUTHIER, Simon, J.; DOUGLAS, Amy Frances; HSIEH, Tom; CHAKKA, Nagasree; CIKOJEVIC, Zoran; WO2010/45251; (2010); (A2) English, View in Reaxys; Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; US2010/94000; (2010); (A1) English, View in Reaxys; Patent; CLAVIS PHARMA ASA; US2010/99654; (2010); (A1) English, View in Reaxys; Fearnley, Stephen Philip; Thongsornkleeb, Charnsak; Journal of Organic Chemistry; vol. 75; nb. 3; (2010); p. 933 - 936, View in Reaxys; Josien, Hubert; Bara, Thomas; Rajagopalan, Murali; Clader, John W.; Greenlee, William J.; Favreau, Leonard; Hyde, Lynn A.; Nomeir, Amin A.; Parker, Eric M.; Song, Lixin; Zhang, Lili; Zhang, Qi; Bioorganic and Medicinal Chemistry Letters; vol. 19; nb. 21; (2009); p. 6032 - 6037, View in Reaxys; Banert, Klaus; Joo, Young-Hyuk; Rueffer, Tobias; Walfort, Bernhard; Lang, Heinrich; Tetrahedron Letters; vol. 51; nb. 21; (2010); p. 2880 - 2882, View in Reaxys; Patent; Novartis AG; EP1937248; (2010); (B1) English, View in Reaxys; Lerchner, Andreas; Machauer, Rainer; Betschart, Claudia; Veenstra, Siem; Rueeger, Heinrich; McCarthy, Clive; Tintelnot-Blomley, Marina; Jaton, Anne-Lise; Rabe, Sabine; Desrayaud, Sandrine; Enz, Albert; Staufenbiel, Matthias; Paganetti, Paolo; Rondeau, Jean-Michel; Neumann, Ulf; Bioorganic and Medicinal Chemistry Letters; vol. 20; nb. 2; (2010); p. 603 - 607, View in Reaxys

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Comment (Pharmacological Data)

Bioactivities present

Patent; XENON PHARMACEUTICALS INC.; CADIEUX, Jean-Jacques; CHAFEEV, Mikhail; CHOWDHURY, Sultan; DOUGLAS, Amy Frances; FU, Jianmin; LANGILLE, Jonathan; SUN, Shaoyi; WOOD, Mark; WO2010/78307; (2010); (A1) English, View in Reaxys; Kang, Jun Yong; Connell, Brian T.; Journal of the American Chemical Society; vol. 132; nb. 23; (2010); p. 7826 - 7827, View in Reaxys; Li, Xianfeng; Zhang, Yong-Kang; Liu, Yang; Ding, Charles Z.; Li, Qun; Zhou, Yasheen; Plattner, Jacob J.; Baker, Stephen J.; Qian, Xuelei; Fan, Dazhong; Liao, Liang; Ni, Zhi-Jie; White, Gemma V.; Mordaunt, Jackie E.; Lazarides, Linos X.; Slater, Martin J.; Jarvest, Richard L.; Thommes, Pia; Ellis, Malcolm; Edge, Colin M.; Hubbard, Julia A.; Somers, Don; Rowland, Paul; Nassau, Pamela; McDowell, Bill; Skarzynski, Tadeusz J.; Kazmierski, Wieslaw M.; Grimes, Richard M.; Wright, Lois L.; Smith, Gary K.; Zou, Wuxin; Wright, Jon; Pennicott, Lewis E.; Bioorganic and Medicinal Chemistry Letters; vol. 20; nb. 12; (2010); p. 3550 - 3556, View in Reaxys; Liu, Qingyian; Qian, Wenyuan; Li, Aiwen; Biswas, Kaustav; Chen, Jian Jeffrey; Fotsch, Christopher; Han, Nianhe; Yuan, Chester; Arik, Leyla; Biddlecome, Gloria; Johnson, Eileen; Kumar, Gondi; Lester-Zeiner, Dianna; Ng, Gordon Y.; Hungate, Randall W.; Askew, Benny C.; Bioorganic and Medicinal Chemistry Letters; vol. 20; nb. 15; (2010); p. 4593 - 4597, View in Reaxys; Labsch, Stephan; Ye, Shute; Adler, Andreas; Neudoerfl, Joerg-Martin; Schmalz, HansGuenther; Tetrahedron Asymmetry; vol. 21; nb. 13-14; (2010); p. 1745 - 1751, View in Reaxys; Patent; BristolMyers Squibb Company; US2010/249190; (2010); (A1) English, View in Reaxys; Patent; INFINITY PHARMACEUTICALS, INC.; WO2006/26430; (2006); (A2) English, View in Reaxys; Patent; BRISTOL-MYERS SQUIBB COMPANY; BENDER, John A.; HEWAWASAM, Piyasena; KADOW, John F.; LOPEZ, Omar D.; MEANWELL, Nicholas A.; NGUYEN, Van N.; ROMINE, Jeffrey Lee; SNYDER, Lawrence B.; ST. LAURENT, Denis R.; WANG, Gan; XU, Ningning; BELEMA, Makonen; WO2010/117635; (2010); (A1) English, View in Reaxys; Sun; Frimpong; Tan; Journal of the American Chemical Society; vol. 132; nb. 34; (2010); p. 11841 - 11843, View in Reaxys; Li, Xianfeng; Zhang, Yong-Kang; Liu, Yang; Ding, Charles Z.; Zhou, Yasheen; Li, Qun; Plattner, Jacob J.; Baker, Stephen J.; Zhang, Suoming; Kazmierski, Wieslaw M.; Wright, Lois L.; Smith, Gary K.; Grimes, Richard M.; Crosby, Renae M.; Creech, Katrina L.; Carballo, Luz H.; Slater, Martin J.; Jarvest, Richard L.; Thommes, Pia; Hubbard, Julia A.; Convery, Maire A.; Nassau, Pamela M.; McDowell, William; Skarzynski, Tadeusz J.; Qian, Xuelei; Fan, Dazhong; Liao, Liang; Ni, Zhi-Jie; Pennicott, Lewis E.; Zou, Wuxin; Wright, Jon; Bioorganic and Medicinal Chemistry Letters; vol. 20; nb. 19; (2010); p. 5695 - 5700, View in Reaxys; MacKlin, Todd K.; Micalizio, Glenn C.; Nature Chemistry; vol. 2; nb. 8; (2010); p. 638 - 643, View in Reaxys; Patent; PFIZER INC.; DAROUT, Etzer; DENINNO, Michael, Paul; FUTATSUGI, Kentaro; GUIMARAES, Cristiano, Ruch, Werneck; LEFKER, Bruce, Allen; MASCITTI, Vincent; MCCLURE, Kim, Francis; MUNCHHOF, Michael, John; ROBINSON, Ralph, Pelton, Jr.; WO2010/128414; (2010); (A1) English, View in Reaxys; Patent; EISAI CO., LTD.; WO2006/118351; (2006); (A1) English, View in Reaxys; Patent; CEPHALON, INC.; WO2007/25031; (2007); (A2) English, View in Reaxys; Patent; CYTOKINETICS, INC.; WO2007/56056; (2007); (A2) English, View in Reaxys; Patent; Nettekoven, Matthias; Plancher, Jean-Marc; Richter, Hans; Roche, Olivier; Taylor, Sven; US2007/123525; (2007); (A1) English, View in Reaxys; Patent; Giri, Brij Pal; Dagli, Dinesh; Singh, Pritam; US2007/225498; (2007); (A1) English, View in Reaxys; Patent; Eisai RandD Management Co., Ltd.; EP1867650; (2007); (A1) English, View in Reaxys; Patent; Corbett, Wendy Lea; Grimsby, Joseph Samuel; Haynes, Nancy-Ellen; Kester, Robert Francis; Mahaney, Paige Erin; Racha, Jagdish Kumar; Sarabu, Ramakanth; Wang, Ka; US2003/225283; (2003); (A1) English, View in Reaxys; Patent; GLAXO GROUP LIMITED; PLIVA-ISTRAZIVACKI INSTITUT D.O.O.; WO2006/50943; (2006); (A1) English, View in Reaxys 26 of 37

Comment (Pharmacological Data)

Bioactivities present

Patent; NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD.; BURNS, Christopher, J.; GOSWAMI, Rajesh; JACKSON, Randy, W.; LESSEN, Thomas; LI, Weiping; PEVEAR, Daniel; TIRUNAHARI, Pavan, Kumar; XU, Hongyu; WO2010/130708; (2010); (A1) English, View in Reaxys; Vacher, Bernard; Funes, Philippe; Chopin, Philippe; Cussac, Didier; Heusler, Peter; Tourette, Amelie; Marien, Marc; Journal of Medicinal Chemistry; vol. 53; nb. 19; (2010); p. 6986 - 6995, View in Reaxys; Csatayova, Kristina; Davies, Stephen G.; Lee, James A.; Ling, Kenneth B.; Roberts, Paul M.; Russell, Angela J.; Thomson, James E.; Tetrahedron; vol. 66; nb. 43; (2010); p. 8420 - 8440, View in Reaxys; Lisowski, Carmen E.; Duncan, Juliana R.; Ranieri, Anthony J.; Heard, George L.; Setser; Holmes, Bert E.; Journal of Physical Chemistry A; vol. 114; nb. 38; (2010); p. 10395 - 10402, View in Reaxys; Harthong, Steven; Dubessy, Beatrice; Vachon, Jerome; Aronica, Christophe; Mulatier, JeanChristophe; Dutasta, Jean-Pierre; Journal of the American Chemical Society; vol. 132; nb. 44; (2010); p. 15637 15643, View in Reaxys; Micheli, Fabrizio; Di Fabio, Romano; Giacometti, Angelo; Roth, Adelheid; Moro, Elisa; Merlo, Giancarlo; Paio, Alfredo; Merlo-Pich, Emilio; Tomelleri, Silvia; Tonelli, Federica; Zarantonello, Paola; Zonzini, Laura; Capelli, Anna Maria; Bioorganic and Medicinal Chemistry Letters; vol. 20; nb. 24; (2010); p. 7308 7311, View in Reaxys; Patent; ASTRAZENECA AB; HOLENZ, Joerg; KARLSTROeM, Sofia; KIHLSTROeM, Jacob; KOLMODIN, Karin; LINDSTROeM, Johan; RAKOS, Laszlo; ROTTICCI, Didier; SWAHN, Britt-Marie; VON BERG, Stefan; WO2011/2409; (2011); (A1) English, View in Reaxys; Patent; MERCK SHARP and DOHME CORP.; WOOD, Harold, B.; ADAMS, Alan, D.; SZEWCZYK, Jason, W.; ZHANG, Yong; YANG, Meng; WO2011/19538; (2011); (A1) English, View in Reaxys; Elitzin, Vassil I.; Harvey, Kimberly A.; Kim, Hyunjung; Salmons, Matthew; Sharp, Matthew J.; Tabet, Elie A.; Toczko, Matthew A.; Organic Process Research and Development; vol. 14; nb. 4; (2010); p. 912 - 917, View in Reaxys; Patent; XENON PHARMACEUTICALS INC.; US2011/87027; (2011); (A1) English, View in Reaxys; De Carne-Carnavalet, Benoit; Archambeau, Alexis; Meyer, Christophe; Cossy, Janin; Folleas, Benoit; Brayer, Jean-Louis; Demoute, Jean-Pierre; Organic Letters; vol. 13; nb. 5; (2011); p. 956 - 959, View in Reaxys; Patent; Aebi, Johannes; Binggeli, Alfred; Green, Luke; Hartmann, Guido; Maerki, Hans P.; Mattei, Patrizio; US2011/92698; (2011); (A1) English, View in Reaxys; Patent; F. HOFFMANN-LA ROCHE AG; AE-

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BI, Johannes; BINGGELI, Alfred; GREEN, Luke; HARTMANN, Guido; MAERKI, Hans P.; MATTEI, Patrizio; WO2011/48032; (2011); (A1) English, View in Reaxys; Patent; GLAXOSMITHKLINE LLC; BASKARAN, Subramanian; BOTYANSZKI, Janos; COOPER, Joel P.; DUAN, Maosheng; KAZMIERSKI, Wieslaw Mieczyslaw; MCFADYEN, Robert Blount; REDMAN, Aniko; WO2011/50146; (2011); (A1) English, View in Reaxys; Chowdhury, Pritish; Borah, Juri Moni; Goswami, Papori; Das, Archana Moni; Steroids; vol. 76; nb. 5; (2011); p. 497 - 501, View in Reaxys; Venier, Olivier; Pascal, Cecile; Braun, Alain; Namane, Claudie; Mougenot, Patrick; Crespin, Olivier; Pacquet, Franois; Mougenot, Cecile; Monseau, Catherine; Onofri, Benedicte; Dadji-Faihun, Rommel; Leger, Celine; Ben-Hassine, Majdi; Van-Pham, Thao; Ragot, Jean-Luc; Philippo, Christophe; Guessregen, Stefan; Engel, Christian; Farjot, Geraldine; Noah, Lionel; Maniani, Karima; Nicolai, Eric; Bioorganic and Medicinal Chemistry Letters; vol. 21; nb. 8; (2011); p. 2244 - 2251, View in Reaxys; Patent; BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen; WO2011/59850; (2011); (A1) English, View in Reaxys; Szewczyk, Jason W.; Acton, John; Adams, Alan D.; Chicchi, Gary; Freeman, Stanley; Howard, Andrew D.; Huang, Yong; Li, Cai; Meinke, Peter T.; Mosely, Ralph; Murphy, Elizabeth; Samuel, Rachel; Santini, Conrad; Yang, Meng; Zhang, Yong; Zhao, Kake; Wood, Harold B.; Bioorganic and Medicinal Chemistry Letters; vol. 21; nb. 9; (2011); p. 2665 - 2669, View in Reaxys; Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; LLINAS-BRUNET , Montse; BORDELEAU, Josee; GODBOUT, Cedrickx; LEBLANC, Melissa; MOREAU, BenoIt; O'MEARA, Jeffrey; WO2011/63502; (2011); (A1) English, View in Reaxys; Dong, Lin; Deng, Lujiang; Lim, Yee Hwee; Leung, Gulice Y. C.; Chen, David Y.-K.; Chemistry - A European Journal; vol. 17; nb. 21; (2011); p. 5778 - 5781, View in Reaxys 27 of 37

Comment (Pharmacological Data)

Bioactivities present

Dai, Chaoyang; Li, Dansu; Popovici-Muller, Janeta; Zhao, Lianyun; Girijavallabhan, Vinay M.; Rosner, Kristin E.; Lavey, Brian J.; Rizvi, Razia; Shankar, Bandarpalle B.; Wong, Michael K.C.; Guo, Zhuyan; Orth, Peter; Strickland, Corey O.; Sun, Jing; Niu, Xiaoda; Chen, Shiying; Kozlowski, Joseph A.; Lundell, Daniel J.; Piwinski, John J.; Shih, Neng-Yang; Siddiqui, M. Arshad; Bioorganic and Medicinal Chemistry Letters; vol. 21; nb. 10; (2011); p. 3172 - 3176, View in Reaxys; Patent; ELI LILLY AND COMPANY; US2011/144091; (2011); (A1) English, View in Reaxys; Kranz, Darius Paul; Meier Zu Greffen, Aike; El Sheikh, Sherif; Neudoerfl, Joerg Martin; Schmalz, Hans-Guenther; European Journal of Organic Chemistry; nb. 15; (2011); p. 2860 - 2866, View in Reaxys; Patent; BRISTOL-MYERS SQUIBB COMPANY; BELEMA, Makonen; ROMINE, Jeffrey, Lee; NGUYEN, Van, N.; WANG, Gan; LOPEZ, Omar, D.; ST. LAURENT, Denis, R.; CHEN, Qi; BENDER, John, A.; YANG, Zhong; HEWAWASAM, Piyasena; XU, Ningning; MEANWELL, Nicholas, A.; EASTER, John, A.; SU, Bao-Ning; SMITH, Michael, J.; WO2011/75439; (2011); (A1) English, View in Reaxys; Patent; Alkermes, Inc.; US2011/166128; (2011); (A1) English, View in Reaxys; Orr, Suvi T.M.; Cabral, Shawn; Fernando, Dilinie P.; Makowski, Teresa; Tetrahedron Letters; vol. 52; nb. 28; (2011); p. 3618 - 3620, View in Reaxys; Nakamura, Ken-Ichi; Takashima, Tsuyoshi; Shirahata, Takashi; Hino, Shojun; Hasegawa, Masashi; Mazaki, Yasuhiro; Misaki, Yohji; Organic Letters; vol. 13; nb. 12; (2011); p. 3122 - 3125, View in Reaxys; Vachon, Jerome; Harthong, Steven; Jeanneau, Erwann; Aronica, Christophe; Vanthuyne, Nicolas; Roussel, Christian; Dutasta, Jean-Pierre; Organic and Biomolecular Chemistry; vol. 9; nb. 14; (2011); p. 5086 - 5091, View in Reaxys; Patent; Bhattacharya, Samit K.; Cameron, Kimberly O.; Fernando, Dilinie P.; McClure, Kim F.; Kung, Daniel W.; Londregan, Allyn T.; Simila, Suvi T. M.; US2011/230461; (2011); (A1) English, View in Reaxys; Patent; ALLERGAN, INC.; US2011/263661; (2011); (A1) English, View in Reaxys; Deguire, Sean M.; Ma, Shutao; Sulikowski, Gary A.; Angewandte Chemie - International Edition; vol. 50; nb. 42; (2011); p. 9940 - 9942, View in Reaxys; Batt, Frederic; Fache, Fabienne; European Journal of Organic Chemistry; nb. 30; (2011); p. 6039 - 6055, View in Reaxys; Mousseau, James J.; Bull, James A.; Ladd, Carolyn L.; Fortier, Angelique; Sustac Roman, Daniela; Charette, Andre B.; Journal of Organic Chemistry; vol. 76; nb. 20; (2011); p. 8243 - 8261, View in Reaxys; Soltanirad, Mohammad Navid; Behrouz, Somayeh; Nekoei, Abdo Reza; Faghih, Zeinab; Khalafi-Nezhad, Ali; Synthesis; nb. 24; (2011); p. 4068 - 4076; Art.No: Z79811SS, View in Reaxys; Patent; PFIZER INC.; ASPNES, Gary Erik; DIDIUK, Mary Theresa; GUZMAN-PEREZ, Angel; MAGUIRE, Robert John; WO2011/158149; (2011); (A1) English, View in Reaxys; Patent; BRISTOLMYERS SQUIBB COMPANY; ROMINE, Jeffrey Lee; WO2012/18325; (2012); (A1) English, View in Reaxys; Patent; BRISTOL-MYERS SQUIBB COMPANY; BELEMA, Makonen; SRINIVASU, Pothukanuri; BENDER, John A.; LOPEZ, Omar D.; CHEN, Qi; RAMPULLA, Richard A.; GUPTA, Samayamunthula Venkata Satya Arun Kumar; MEANWELL, Nicholas A.; WO2012/21591; (2012); (A1) English, View in Reaxys; Jierry, Loic; Harthong, Steven; Aronica, Christophe; Mulatier, Jean-Christophe; Guy, Laure; Guy, Stephan; Organic Letters; vol. 14; nb. 1; (2012); p. 288 - 291, View in Reaxys; Rodriguez-Solla, Humberto; Concellon, Carmen; Tuya, Paula; GarciaGranda, Santiago; Diaz, M. Rosario; Advanced Synthesis and Catalysis; vol. 354; nb. 2-3; (2012); p. 295 - 300, View in Reaxys; Patent; BRISTOL-MYERS SQUIBB COMPANY; BELEMA, Makonen; HEWAWASAM, Piyasena; WO2012/39717; (2012); (A1) English, View in Reaxys 28 of 37

Comment (Pharmacological Data)

Bioactivities present

Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; THIBEAULT, Carl; EDWARDS, Paul, J.; KUHN, Cyrille; MOREAU, BenoIt; POIRIER, Maude; SURPRENANT, Simon; WO2012/48421; (2012); (A1) English, View in Reaxys; Patent; LUPIN LIMITED; PADIYA, Kamlesh, Jyotindra; NAIR, Prathap, S.; PAL, Ravindra, Ramsurat; CHAURE, Ganesh, Shankar; GUDADE, Ganesh, Bhausaheb; PARKALE, Santosh, Sadashiv; MANOJKUMAR, Vishwanath, Lohar; SWAPNIL, Ramesh, Bajare; SMITA, Aditya, Bhoskar; SACHIN, Dilip, Survase; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar; WO2012/49555; (2012); (A1) English, View in Reaxys; Klahn, Philipp; Duschek, Alexander; Liebert, Clemence; Kirsch, Stefan F.; Organic Letters; vol. 14; nb. 5; (2012); p. 1250 - 1253, View in Reaxys; Patent; MERCK SHARP and DOHME CORP.; LU, Zhijian; CHEN, Yi-Heng; SMITH, Cameron; LI, Hong; THOMPSON, Christopher, F.; SWEIS, Ramzi; SINCLAIR, Peter; KALLASHI, Florida;

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HUNT, Julianne; ADAMSON, Samantha, E.; DONG, Guizhen; ONDEYKA, Debra, L.; QIAN, Xiaoxia; SUN, Wanying; VACHAL, Petr; ZHAO, Kake; WO2012/58187; (2012); (A1) English, View in Reaxys; Friestad, Gregory K.; Ji, An; Baltrusaitis, Jonas; Korapala, Chandra Sekhar; Qin, Jun; Journal of Organic Chemistry; vol. 77; nb. 7; (2012); p. 3159 - 3180, View in Reaxys; Kadow, John F.; Ueda, Yasutsugu; Meanwell, Nicholas A.; Connolly, Timothy P.; Wang, Tao; Chen, Chung-Pin; Yeung, Kap-Sun; Zhu, Juliang; Bender, John A.; Yang, Zhong; Parker, Dawn; Lin, Pin-Fang; Colonno, Richard J.; Mathew, Marina; Morgan, Daniel; Zheng, Ming; Chien, Caly; Grasela, Dennis; Journal of Medicinal Chemistry; vol. 55; nb. 5; (2012); p. 2048 - 2056, View in Reaxys; Pemha, Rene; Pegnyemb, Dieudonne Emmanuel; Mosset, Paul; Tetrahedron; vol. 68; nb. 14; (2012); p. 2973 - 2983, View in Reaxys; Francois, Cyril; Boddaert, Thomas; Durandetti, Muriel; Querolle, Olivier; Van Hijfte, Luc; Meerpoel, Lieven; Angibaud, Patrick; Maddaluno, Jacques; Organic Letters; vol. 14; nb. 8; (2012); p. 2074 2077, View in Reaxys; Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/157425; (2012); (A1) English, View in Reaxys; Chu, Lin; Armstrong, Helen M.; Chang, Linda L.; Cheng, Amy F.; Colwell, Lawrence; Cui, Jisong; Evans, Jilly; Galka, Amy; Goulet, Mark T.; Hayes, Nancy; Lo, Jane; Menke, John; Ok, Hyun O.; Ondeyka, Debra L.; Patel, Minal; Quaker, Grace M.; Sings, Heather; Witkin, Stephanie L.; Zhao, Annie; Ujjainwalla, Feroze; Bioorganic and Medicinal Chemistry Letters; vol. 22; nb. 12; (2012); p. 4133 - 4138, View in Reaxys; Putty, Sandeep; Rai, Aman; Jamindar, Darshan; Pagano, Paul; Quinn, Cheryl L.; Mima, Takehiko; Schweizer, Herbert P.; Gutheil, William G.; Chemical Biology and Drug Design; vol. 78; nb. 5; (2011); p. 757 - 763, View in Reaxys; Patent; BAYER PHARMA AKTIENGESELLSCHAFT; US2012/172448; (2012); (A1) English, View in Reaxys; Patent; UNIVERSITY OF NOTTINGHAM; BAKER, Jillian G.; FISCHER, Peter M.; FROMONT, Christophe; GARDINER, Sheila M.; HILL, Stephen J.; JADHAV, Gopal; KELLAM, Barrie; MISTRY, Shailesh; WOOLARD, Jeanette; WO2012/104659; (2012); (A1) English, View in Reaxys; Patent; BRISTOL-MYERS SQUIBB COMPANY; BENDER, John, A.; LOPEZ, Omar, D.; WANG, Gan; BELEMA, Makonen; KADOW, John, F.; WO2012/109080; (2012); (A1) English, View in Reaxys; Varchi, Greta; Guerrini, Andrea; Tesei, Anna; Brigliadori, Giovanni; Bertucci, Carlo; Di Donato, Marzia; Castoria, Gabriella; ACS Medicinal Chemistry Letters; vol. 3; nb. 6; (2012); p. 454 - 458, View in Reaxys; Patent; MITSUBISHI TANABE PHARMA CORPORATION; TSUZUKI, Yasuyuki; SAWAMOTO, Daisuke; SAKAMOTO, Toshiaki; KATO, Taku; NIWA, Yasuki; AWAI, Nobumasa; WO2012/124825; (2012); (A1) English, View in Reaxys; Patent; MERCK SHARP and DOHME CORP.; EDMONDSON, Scott; GUO, Zhiqiang; GEISS, William, B.; WOOD, Harold, B.; STAMFORD, Andrew, W.; MILLER, Michael, W.; DEMONG, Duane, E.; MORRIELLO, Gregori, J.; ANAND, Rajan; COLANDREA, Vincent, J.; MACALA, Megan; MALETIC, Milana; ZHU, Cheng; ZHU, Yuping; SUN, Wanying; ZHAO, Kake; HUANG, Yong; HARRIS, Joel, M.; CHANG, Lehua; KAR, Nam Fung; HU, Zhiyong; WANG, Liping; WANG, Bowei; LIU, Ping; SZEWCZYK, Jason, W.; WO2012/138845; (2012); (A1) English, View in Reaxys; Sarabu, Ramakanth; Bizzarro, Fred T.; Corbett, Wendy L.; Dvorozniak, Mark T.; Geng, Wanping; Grippo, Joseph F.; Haynes, Nancy-Ellen; Hutchings, Stanley; Garofalo, Lisa; Guertin, Kevin R.; Hilliard, Darryl W.; Kabat, Marek; Kester, Robert F.; Ka, Wang; Liang, Zhenmin; Mahaney, Paige E.; Marcus, Linda; Matschinsky, Franz M.; Moore, David; Racha, Jagdish; Radinov, Roumen; Ren, Yi; Qi, Lida; Pignatello, Michael; Spence, Cheryl L.; Steele, Thomas; Tengi, John; Grimsby, Joseph; Journal of Medicinal Chemistry; vol. 55; nb. 16; (2012); p. 7021 - 7036, View in Reaxys; Patent; BRISTOL-MYERS SQUIBB COMPANY; CHEN, Qi; LOPEZ, Omar D.; BENDER, John A.; WANG, Gan; NGUYEN, Van N.; KADOW, John F.; MEANWELL, Nicholas A.; BELEMA, Makonen; WO2012/154777; (2012); (A1) English, View in Reaxys; Farmer, Jennifer L.; Hunter, Howard N.; Organ, Michael G.; Journal of the American Chemical Society; vol. 134; nb. 42; (2012); p. 17470 - 17473, View in Reaxys 29 of 37

Comment (Pharmacological Data)

Bioactivities present

Zheng, Bin; Sugiyama, Masano; Eastgate, Martin D.; Fritz, Alan; Murugesan, Saravanababu; Conlon, David A.; Organic Process Research and Development; vol. 16; nb. 11; (2012); p. 1827 - 1831, View in Reaxys; Nishimura, Rodolfo H.V.; Toledo, Fabiano T.; Lopes, Joao L.C.; Clososki, Giuliano C.; Tetrahedron Letters; vol. 54; nb. 4; (2013); p. 287 - 290, View in Reaxys; Lin, Hongkun; Pei, Wenbo; Wang, Hao; Houk, Kendall N.; Krauss, Isaac J.; Journal of the American Chemical Society; vol. 135; nb. 1; (2013); p. 82 - 85, View in Reaxys; Patent; MERCK SHARP and DOHME CORP.; MCCOMAS, Casey Cameron; LIVERTON, Nigel J.; HABERMANN, Joerg; KOCH, Uwe; NARJES, Frank; LI, Peng; PENG, Xuanjia; SOLL, Richard; WU, Hao; WO2013/33900; (2013); (A1) English, View in Reaxys; Patent; MERCK SHARP and DOHME CORP.; MCCOMAS, Casey Cameron; LIVERTON, Nigel J.; HABERMANN, Joerg; KOCH, Uwe; NARJES, Frank; LI, Peng; PENG, Xuanjia; SOLL, Richard; WU, Hao; PALANI, Anandan; HE, Shuwen; DAI, Xing; LIU, Hong; LAI, Zhong; LONDON, Clare; XIAO, Dong; ZORN, Nicolas; NARGUND, Ravi; WO2013/33971; (2013); (A1) English, View in Reaxys; Patent; MERCK SHARP and DOHME CORP.; DWYER, Michael, P.; KEERTIKAR, Kartik, M.; ZENG, Qingbei; MAZZOLA, Robert, D., Jr.; CALDWELL, John, P.; TANG, Haiqun; NAIR, Anilkumar Gopinadhan; SHANKAR, Bandarpalle, B.; ROSENBLUM, Stuart, B.; KOZLOWSKI, Joseph, A.; WO2013/39878; (2013); (A1) English, View in Reaxys; Patent; MERCK SHARP and DOHME CORP.; DWYER, Michael, P.; KEERTIKAR, Kartik, M.; ZENG, Qingbei; MAZZOLA, Robert, D., Jr.; YU, Wensheng; TANG, Haiqun; KIM, Seong Heon; TONG, Ling; ROSENBLUM, Stuart, B.; KOZLOWSKI, Joseph, A.; NAIR, Anilkumar Gopinadhan; WO2013/39876; (2013); (A1) English, View in Reaxys; Mustard, Thomas J. L.; MacK, Daniel J.; Njardarson, Jon T.; Cheong, Paul Ha-Yeon; Journal of the American Chemical Society; vol. 135; nb. 4; (2013); p. 1471 - 1475, View in Reaxys; Nakamura, Ken-Ichi; Hashimoto, Tomomi; Shirahata, Takashi; Hino, Shojun; Hasegawa, Masashi; Mazaki, Yasuhiro; Misaki, Yohji; Chemistry Letters; vol. 40; nb. 8; (2011); p. 883 - 885, View in Reaxys; Yang, Jun; Yin, Wang; Liu, Jin; Wang, Yu; Zhou, Cheng; Kang, Yi; Zhang, Wen-Sheng; Bioorganic and Medicinal Chemistry Letters; vol. 23; nb. 6; (2013); p. 1813 - 1816, View in Reaxys; Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HAHN, Michael; LAMPE, Thomas; STASCH, Johannes-Peter; SCHLEMMER, Karl-Heinz; WUNDER, Frank; LI, Volkhart Min-Jian; BECKER, EvaMaria; STOLL, Friederike; KNORR, Andreas; WOLTERING, Elisabeth; US2013/79412; (2013); (A1) English, View in Reaxys; Egi, Masahiro; Sugiyama, Koji; Saneto, Moriaki; Hanada, Ryosuke; Kato, Katsuya; Akai, Shu-

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ji; Angewandte Chemie - International Edition; vol. 52; nb. 13; (2013); p. 3654 - 3658; Angew. Chem.; vol. 125; nb. 13; (2013); p. 3742 - 3746, View in Reaxys; Patent; CADILA HEALTHCARE LIMITED; AGARWAL, Sameer; JAIN, Mukul R; PATEL, Pankaj R; WO2013/54338; (2013); (A1) English, View in Reaxys; Patent; Helsinn Healthcare SA; Fadini, Luca; Manini, Peter; Pietra, Claudio; Giuliano, Claudio; Lovati, Emanuela; Cannella, Roberta; Venturini, Alessio; Stella, Valentino J.; US8426450; (2013); (B1) English, View in Reaxys; Pace, Vittorio; Holzer, Wolfgang; Verniest, Guido; Alcantara, Andres R.; De Kimpe, Norbert; Advanced Synthesis and Catalysis; vol. 355; nb. 5; (2013); p. 919 - 926, View in Reaxys; Patent; BLANCHETTE ROCKEFELLER NEUROSCIENCES INSTITUTE; ALKON, Daniel, L.; NELSON, Thomas, J.; WO2013/71281; (2013); (A1) English, View in Reaxys; Patent; BLANCHETTE ROCKEFELLER NEUROSCIENCES INSTITUTE; ALKON, Daniel, L.; NELSON, Thomas, J.; WO2013/71282; (2013); (A1) English, View in Reaxys; Patent; MERCK SHARP and DOHME CORP.; EDMONDSON, Scott; HU, Zhiyong; LIU, Ping; MORRIELLO, Gregori, J.; SZEWCZYK, Jason, W.; WANG, Bowei; WANG, Liping; WOOD, Harold, B.; ZHU, Cheng; ZHU, Yuping; GUO, Zhiqiang; WO2013/74388; (2013); (A1) English, View in Reaxys; Patent; ROTH, Gerald Juergen; FLECK, Martin; LEHMANN-LINTZ, Thorsten; NOSSE, Bernd; US2013/143876; (2013); (A1) English, View in Reaxys; Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ROTH, Gerald Juergen; FLECK, Martin; LEHMANN-LINTZ, Thorsten; NOSSE, Bernd; WO2013/79668; (2013); (A1) English, View in Reaxys 30 of 37

Comment (Pharmacological Data)

Bioactivities present

Patent; FLECK, Martin; NOSSE, Bernd; HEINE, Niklas; ROTH, Gerald Juergen; US2013/158004; (2013); (A1) English, View in Reaxys; He, Shuwen; Li, Peng; Dai, Xing; McComas, Casey C.; Huang, Hongling; Zhan, Chaoliang; Chang, Liang; Liu, Yuehui; Chen, Shaojun; Lai, Zhong; Liu, Hong; Yin, Jingjun; Dang, Qun; Xiao, Dong; Zorn, Nicolas; Peng, Xuanjia; Nargund, Ravi P.; Palani, Anandan; Tetrahedron Letters; vol. 54; nb. 29; (2013); p. 3755 - 3758, View in Reaxys; Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; ROTH, Gerald Juergen; NOSSE, Bernd; HEINE, Niklas; WO2013/92616; (2013); (A1) English, View in Reaxys; Patent; ARDELYX, INC.; LEWIS, Jason, G.; REICH, Nicholas; CHEN, Tao; JACOBS, Jeffrey W.; CHARMOT, Dominique; NAVRE, Marc; FINN, Patricia; CARRERAS, Christopher; SPENCER, Andrew; WO2013/96771; (2013); (A1) English, View in Reaxys; Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; NOSSE, Bernd; ROTH, Gerald, Juergen; WO2013/98375; (2013); (A1) English, View in Reaxys; Patent; FLECK, Martin; NOSSE, Bernd; ROTH, Gerald Juergen; US2013/172316; (2013); (A1) English, View in Reaxys; Patent; SPROTT, Kevin; LEWIS, Michael; CHOI, Hyeongwook; FANG, Frank; SHAN, Mingde; LAZAROVA, Tsvetelina, I; LI, Lin; SIDDIQUI, M., Arshad; LAROUCHE-GAUTHIER, Robin; LEMIRE, Alexandre; WO2013/103993; (2013); (A1) English, View in Reaxys; Patent; Bristol-Myers Squibb Company; Hewawasam, Piyasena; Kadow, John F.; Lopez, Omar D.; Meanwell, Nicholas A.; Tu, Yong; Wang, Alan Xiangdong; Xu, Ningning; Gupta, Samayamunthula Venkata Satya Arun Kumar; Srinivasu, Pothukanuri; Kumar, Indasi Gopi; Kumar, Ponugupati Suresh; Belema, Makonen; Fridell, Robert A.; Gao, Min; Lemm, Julie A.; O'Boyle, II, Donald R.; Sun, Jin-Hua; Wang, Chunfu; Wang, Ying-Kai; US2013/183269; (2013); (A1) English, View in Reaxys; Patent; UNIVERSITY OF TROMSØ; GARDNER, Rebecca; LEJON, Tore; SVENDSEN, John Sigurd; GOROVOY, Alexey; GOZHINA, Olga; WO2013/104897; (2013); (A1) English, View in Reaxys; Chowdhury, Sultan; Liu, Shifeng; Cadieux, Jay A.; Hsieh, Tom; Chafeev, Mikhail; Sun, Shaoyi; Jia, Qi; Sun, Jianyu; Wood, Mark; Langille, Jonathan; Sviridov, Serguei; Fu, Jianmin; Zhang, Zaihui; Chui, Ray; Wang, Audrey; Cheng, Xing; Zhong, Jing; Hossain, Sazzad; Khakh, Kuldip; Rajlic, Ivana; Verschoof, Henry; Kwan, Rainbow; Young, Wendy; Medicinal Chemistry Research; vol. 22; nb. 4; (2013); p. 1825 - 1836, View in Reaxys; Velthuisen, Emile J.; Baughman, Todd M.; Johns, Brian A.; Temelkoff, David P.; Weatherhead, Jason G.; European Journal of Medicinal Chemistry; vol. 63; (2013); p. 202 - 212, View in Reaxys; Patent; MERCK SHARP and DOHME CORP.; LIU, Ping; SZEWCZYK, Jason, W.; WANG, Liping; WOOD, Harold, B.; ZHU, Cheng; EDMONDSON, Scott, D.; WO2013/122821; (2013); (A1) English, View in Reaxys; Pace, Vittorio; Castoldi, Laura; Holzer, Wolfgang; Journal of Organic Chemistry; vol. 78; nb. 15; (2013); p. 7764 - 7770, View in Reaxys; Huang, Jun; Fang, Lichao; Long, Rong; Shi, Li-Li; Shen, Hong-Juan; Li, Chuang-Chuang; Yang, Zhen; Organic Letters; vol. 15; nb. 15; (2013); p. 4018 - 4021, View in Reaxys; Brill, Marcel; Kuehnel, Erik; Scriban, Corina; Rominger, Frank; Hofmann, Peter; Dalton Transactions; vol. 42; nb. 36; (2013); p. 12861 - 12864, View in Reaxys; McClure, Kim F.; Jackson, Margaret; Cameron, Kimberly O.; Kung, Daniel W.; Perry, David A.; Orr, Suvi T.M.; Zhang, Yingxin; Kohrt, Jeffrey; Tu, Meihua; Gao, Hua; Fernando, Dilinie; Jones, Ryan; Erasga, Noe; Wang, Guoqiang; Polivkova, Jana; Jiao, Wenhua; Swartz, Roger; Ueno, Hirokazu; Bhattacharya, Samit K.; Stock, Ingrid A.; Varma, Sam; Bagdasarian, Victoria; Perez, Sylvie; Kelly-Sullivan, Dawn; Wang, Ruduan; Kong, Jimmy; Cornelius, Peter; Michael, Laura; Lee, Eunsun; Janssen, Ann; Steyn, Stefanus J.; Lapham, Kimberly; Goosen, Theunis; Bioorganic and Medicinal Chemistry Letters; vol. 23; nb. 19; (2013); p. 5410 - 5414, View in Reaxys; Gorovoy, Alexey S.; Gozhina, Olga; Svendsen, John-Sigurd; Tetz, George V.; Domorad, Anna; Tetz, Victor V.; Lejon, Tore; Journal of Peptide Science; vol. 19; nb. 10; (2013); p. 613 - 618, View in Reaxys; Pace, Vittorio; Castoldi, Laura; Holzer, Wolfgang; Chemical Communications; vol. 49; nb. 75; (2013); p. 8383 - 8385, View in Reaxys; Xu, Huiying; Zhang, Xiting; Ke, Zhuo-Feng; Li, Zhi-Feng; Xu, Xian-Yan; Su, Cheng-Yong; Phillips, David Lee; Zhao, Cunyuan; RSC Advances; vol. 3; nb. 38; (2013); p. 17131 - 17142, View in Reaxys; Patent; INCEPTION 2, INC.; STOCK, Nicholas, Simon; CHEN, Austin, Chih-Yu; BRAVO, Yalda, Mostofi; JACINTHO, Jason, Duarte; SCOTT, Jill, Melissa; STEARNS, Brian, Andrew; CLARK, Ryan, Christopher; TRUONG, Yen, Pham; WO2013/134562; (2013); (A1) English, View in Reaxys 31 of 37

Comment (Pharmacological Data)

Bioactivities present

Patent; ALMIRALL, S.A.; DRACONIS PHARMA, S.L.; LABORATORIOS DEL DR. ESTEVE, S.A.; AGUILAR, Nuria; FERNANDEZ, Joan, Carles; TERRICABRAS, Emma; CARCELLER GONZALEZ, Elena; GARCIA GARCIA,

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Francisco, Javier; SALAS SOLANA, Jordi; WO2013/149996; (2013); (A1) English, View in Reaxys; Patent; PFIZER INC.; AHN, Kay; BOEHM, Markus; CABRAL, Shawn; CARPINO, Philip A.; FUTATSUGI, Kentaro; HEPWORTH, David; KUNG, Daniel W.; ORR, Suvi; WANG, Jian; WO2013/150416; (2013); (A1) English, View in Reaxys; Wang, Yizhong; Wang, Chao; Butler, John R.; Ready, Joseph M.; Angewandte Chemie - International Edition; vol. 52; nb. 41; (2013); p. 10796 - 10799; Angew. Chem.; vol. 52-41; (2013); p. 10796 - 10799,4, View in Reaxys; Wang, Gan; James, Clint A.; Meanwell, Nicholas A.; Hamann, Lawrence G.; Belema, Makonen; Tetrahedron Letters; vol. 54; nb. 49; (2013); p. 6722 - 6724, View in Reaxys; Arpin, Patrice; Hill, Bryan; Larouche-Gauthier, Robin; Spino, Claude; Canadian Journal of Chemistry; vol. 91; nb. 12; (2013); p. 1193 - 1201, View in Reaxys; Patent; Gilead Sciences, Inc.; Scott, Robert William; Vitale, Justin Philip; Matthews, Kenneth Stanley; Teresk, Martin Gerald; Formella, Alexandra; Evans, Jared Wayne; US2013/324740; (2013); (A1) English, View in Reaxys; Patent; PFIZER INC.; DENNEY, William S.; JACKSON, Margaret; SONNENBERG, Gabriele; WO2013/182933; (2013); (A1) English, View in Reaxys; Patent; SUNOVION PHARMACEUTICALS INC.; CAMPBELL, John, Emmerson; JONES, Phillip, G.; MALCOLM, Scott; WO2013/192273; (2013); (A1) English, View in Reaxys; Patent; NOVARTIS AG; ALTMANN, Eva; HOMMEL, Ulrich; LORTHIOIS, Edwige, Liliane, Jeanne; MAIBAUM, Juergen, Klaus; OSTERMANN, Nils; QUANCARD, Jean; RANDL, Stefan, Andreas; VULPETTI, Anna; WO2014/2054; (2014); (A1) English, View in Reaxys; Patent; NOVARTIS AG; ALTMANN, Eva; HOMMEL, Ulrich; LORTHIOIS, Edwige Liliane Jeanne; MAIBAUM, Juergen Klaus; OSTERMANN, Nils; QUANCARD, Jean; RANDL, Stefan Andreas; VULPETTI, Anna; FLOHR, Stefanie; WO2014/2058; (2014); (A2) English, View in Reaxys; Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BODIL VAN NIEL, Monique; FAUBER, Benjamin; GAINES, Simon; GOBBI, Alberto; RENE, Olivier; VESEY, David; WARD, Stuart; WO2014/9447; (2014); (A1) English, View in Reaxys; Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; TAN, Yumei; LUO, Huichao; WO2014/19344; (2014); (A1) English, View in Reaxys; Siega, Patrizia; Dreos, Renata; Brancatelli, Giovanna; Zangrando, Ennio; Tavagnacco, Claudio; Vrdoljak, Visnja; Hrenar, Tomica; Organometallics; vol. 33; nb. 4; (2014); p. 909 - 920, View in Reaxys; Patent; MERCK SHARP and DOHME CORP.; PLUMMER, Christopher, W.; BIFTU, Tesfaye; CHOBANIAN, Harry; WO2014/28318; (2014); (A1) English, View in Reaxys; Patent; Boehringer Ingelheim International GmbH; FLECK, Martin; HEINE, Niklas; NOSSE, Bernd; ROTH, Gerald Juergen; US2014/100211; (2014); (A1) English, View in Reaxys; Morgan, Kate F.; Hollingsworth, Ian A.; Bull, James A.; Chemical Communications; vol. 50; nb. 40; (2014); p. 5203 - 5205, View in Reaxys; Jansen, Koen; Heirbaut, Leen; Verkerk, Robert; Cheng, Jonathan D.; Joossens, Jurgen; Cos, Paul; Maes, Louis; Lambeir, Anne-Marie; De Meester, Ingrid; Augustyns, Koen; Van Der Veken, Pieter; Journal of Medicinal Chemistry; vol. 57; nb. 7; (2014); p. 3053 - 3074, View in Reaxys; Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; HEIMANN, Annekatrin; HEINE, Niklas; NOSSE, Bernd; ROTH, Gerald Juergen; WO2014/56771; (2014); (A1) English, View in Reaxys; Nakamura, Ken-Ichi; Okada, Yuuki; Shirahata, Takashi; Misaki, Yohji; Chemistry Letters; vol. 43; nb. 5; (2014); p. 708 - 710, View in Reaxys; Pace, Vittorio; Castoldi, Laura; Holzer, Wolfgang; Advanced Synthesis and Catalysis; vol. 356; nb. 8; (2014); p. 1761 - 1766, View in Reaxys 32 of 37

Comment (Pharmacological Data)

Bioactivities present

Tymtsunik, Andriy V.; Ivon, Yevhen M.; Komarov, Igor V.; Grygorenko, Oleksandr O.; Tetrahedron Letters; vol. 55; nb. 22; (2014); p. 3312 - 3315, View in Reaxys; Guo, Boying; Vitaku, Edon; Njardarson, Jon T.; Tetrahedron Letters; vol. 55; nb. 21; (2014); p. 3232 - 3234, View in Reaxys; Patent; MERCK SHARP and DOHME CORP.; BESHORE, Douglas, C.; JOHNSON, Adam, W.; KUDUK, Scott, D.; REGER, Thomas, S.; WO2014/78217; (2014); (A1) English, View in Reaxys; Patent; SUNSHINE LAKE PHARMA CO.,LTD.; ZHANG, Jiancun; ZHANG, Yingjun; XIE, Hongming; REN, Qingyun; HU, Bailin; FU, Changping; WU, Xiwei; LI, Shifeng; WANG, Chenglin; ZHANG, Zhikeng; WO2014/82379; (2014); (A1) English, View in Reaxys; Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; LI, Shifeng; FU, Changping; HU, Bailin; WU, Xiwei; TANG, Changhua; WO2014/82380; (2014); (A1) English, View in Reaxys; Patent; VENATORX PHARMACEUTICALS, INC; BURNS, Christopher, J.; DAIGLE, Denis; LIU, Bin; MCGARRY, Daniel; PEVEAR, Daniel C.; TROUT, Robert E. Lee; WO2014/89365; (2014); (A1) English, View in Reaxys; Tresse, Cedric; Guissart, Celine; Schweizer, Stephane; Bouhoute, Yassine; Chany, Anne-Caroline; Goddard, Mary-Lorene; Blanchard, Nicolas; Evano, Gwilherm; Advanced Synthesis and Catalysis; vol. 356; nb. 9; (2014); p. 2051 - 2060, View in Reaxys; Patent; Reddy, Raja; Glinka, Tomasz; Totrov, Maxim; Hecker, Scott; US2014/194382; (2014); (A1) English, View in Reaxys; Patent; Sunshine Lake Pharma Co., Ltd; ZHANG, Jiancun; ZHANG, Yingjun; XIE, Hongming; REN, Qingyun; LUO, Huichao; YU, Tianzhu; TAN, Yumei; EP2730572; (2014); (A1) English, View in Reaxys; Patent; Liverton, Nigel J.; McComas, Casey Cameron; Habermann, Joerg; Koch, Uwe; Narjes, Frank; Li, Peng; Peng, Xuanjia; Soll, Richard; Wu, Hao; Palani, Anandan; He, Shuwen; Dai, Xing; Liu, Hong; Lai, Zhong; London, Clare; Xiao, Dong; Zorn, Nicolas; Nargund, Ravi; US2014/213571; (2014); (A1) English, View in Reaxys; Boddaert, Thomas; Francois, Cyril; Mistico, Laetitia; Querolle, Olivier; Meerpoel, Lieven; Angibaud, Patrick; Durandetti, Muriel; Maddaluno, Jacques; Chemistry - A European Journal; vol. 20; nb. 32; (2014); p. 10131 - 10139, View in Reaxys; Patent; MERCK SHARP and DOHME CORP.; HE, Shuwen; DAI, Xing; PALANI, Anandan; NARGUND, Ravi; LAI, Zhong; ZORN, Nicolas; XIAO, Dong; DANG, Qun; LI, Peng; PENG, Xuanjia; SOLL, Richard; WO2014/121418; (2014); (A1) English, View in Reaxys; Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; HU, Bailin; LI, Shifeng; WU, Xiwei; TANG, Changhua; WANG, Chenglin; FANG, Qinghong; YU, Quanxing; ZHANG, Zhikeng; WO2014/131315; (2014); (A1) English, View in Reaxys; Patent; NOVARTIS AG; CAFERRO, Thomas Raymond; CHEN, Zhuoliang; CHO, Young Shin; COSTALES, Abran Q.; LEVELL, Julian Roy; LIU, Gang; MANNING, James R.; SENDZIK, Martin; SHAFER, Cynthia; SHULTZ, Michael David; SUTTON, James; WANG, Yaping; ZHAO, Qian; WO2014/141104; (2014); (A1) English, View in Reaxys; Patent; VENATORX PHARMACEUTICALS, INC.; BURNS, Christopher, J.; DAIGLE, Denis; LIU, Bin; MCGARRY, Daniel; PEVEAR, Daniel, C.; TROUT, Rob-

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ert, E. Lee; WO2014/151958; (2014); (A1) English, View in Reaxys; Janetzko, John; Batey, Robert A.; Journal of Organic Chemistry; vol. 79; nb. 16; (2014); p. 7415 - 7424, View in Reaxys; Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; MYERS, Andrew, G.; SEIPLE, Ian, Bass; ZHANG, Ziyang; WO2014/165792; (2014); (A2) English, View in Reaxys; Xiong, Hui; Chen, Brendan; Durand-Rville, Thomas F.; Joubran, Camil; Alelyunas, Yun W.; Wu, Dedong; Huynh, Hoan; ACS Medicinal Chemistry Letters; vol. 5; nb. 10; (2014); p. 1143 - 1147, View in Reaxys; Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; FAUBER, Benjamin; RENE, Olivier; WO2014/202741; (2014); (A1) English, View in Reaxys; Pace, Vittorio; Castoldi, Laura; Mamuye, Ashenafi Damtew; Holzer, Wolfgang; Synthesis (Germany); vol. 46; nb. 21; (2014); p. 2897 - 2909; Art.No: SS2014-Z0416FA, View in Reaxys 33 of 37

Comment (Pharmacological Data)

Bioactivities present

Patent; MERCK SHARP and DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; NARGUND, Ravi; XIAO, Dong; ZORN, Nicolas; DANG, Qun; MCCOMAS, Casey C.; PENG, Xuanjia; LI, Peng; SOLL, Richard; WO2014/205593; (2014); (A1) English, View in Reaxys; Patent; MERCK SHARP and DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; NARGUND, Ravi; XIAO, Dong; ZORN, Nicolas; DANG, Qun; MCCOMAS, Casey, C.; PENG, Xuanjia; LI, Peng; SOLL, Richard; WO2014/209727; (2014); (A1) English, View in Reaxys; Degennaro, Leonardo; Fanelli, Flavio; Giovine, Arianna; Luisi, Renzo; Advanced Synthesis and Catalysis; vol. 357; nb. 1; (2015); p. 21 - 27, View in Reaxys; El Bouakher, Abderrahman; Massip, Stphane; Jarry, Christian; Troin, Yves; Abrunhosa-Thomas, Isabelle; Guillaumet, Grald; European Journal of Organic Chemistry; vol. 2015; nb. 3; (2015); p. 556 - 559, View in Reaxys; Ma, Yu-Heng; Wu, Gang; Jiang, Nan; Ge, Shu-Wang; Zhou, Qian; Sun, Bai-Wang; Chinese Chemical Letters; vol. 26; nb. 1; (2015); p. 81 - 84, View in Reaxys; Patent; BRISTOL-MYERS SQUIBB COMPANY; HEWAWASAM, Piyasena; LOPEZ, Omar D.; TU, Yong; WANG, Alan Xiangdong; XU, Ningning; KADOW, John F.; MEANWELL, Nicholas A.; GUPTA, Samayamunthula Venkata Satya Arun Kumar; KUMAR, Indasi J. Gopi; PUNUGUPATI, Suresh Kumar; BELEMA, Makonen; WO2015/5901; (2015); (A1) English, View in Reaxys; Patent; SAGE THERAPEUTICS, INC.; MARTINEZ BOTELLA, Gabriel; HARRISON, Boyd L.; ROBICHAUD, Albert, Jean; SALITURO, Francesco Gerald; WO2015/10054; (2015); (A2) English, View in Reaxys; Patent; University of Tromsø; Lejon, Tore; Svendsen, John Sigurd; Gorovoy, Alexey; Gozhina, Olga; US2015/18311; (2015); (A1) English, View in Reaxys; Li, Yang; Fiers, William D.; Bernard, Steffen M.; Smith, Janet L.; Aldrich, Courtney C.; Fecik, Robert A.; ACS Chemical Biology; vol. 9; nb. 12; (2014); p. 2914 - 2922, View in Reaxys; Patent; Hewawasam, Piyasena; Lopez, Omar D.; Tu, Yong; Wang, Alan Xiangdong; Xu, Ningning; Kadow, John F.; Meanwell, Nicholas A.; Gupta, Samayamuthula Venkata Satya Arun Kumar; Kumar, Indasi J. Gopi; Ponugupati, Suresh Kumar; Belema, Makonen; US2015/23913; (2015); (A1) English, View in Reaxys; Patent; ENANTA PHARMACEUTICALS, INC.; NOVARTIS AG; QIU, Yao-ling; CAO, Hui; PENG, Xiaowen; GAO, Xuri; OR, Yat, Sun; SWEENEY, Zachary, Kevin; WO2015/17382; (2015); (A1) English, View in Reaxys; Parasram, Marvin; Iaroshenko, Viktor O.; Gevorgyan, Vladimir; Journal of the American Chemical Society; vol. 136; nb. 52; (2014); p. 17926 - 17929, View in Reaxys; Castagnolo, Daniele; Degennaro, Leonardo; Luisi, Renzo; Clayden, Jonathan; Organic and Biomolecular Chemistry; vol. 13; nb. 8; (2015); p. 2330 - 2340, View in Reaxys; Patent; CHARLES, Mark David; BROOKFIELD, Joanna Lola; EKWURU, Chukuemeka Tennyson; STOCKLEY, Martin Lee; WO2015/25172; (2015); (A1) English, View in Reaxys; Patent; Hendricks, Robert Than; Beigelman, Leonid; Smith, David Bernard; Stoycheva, Antitsa Dimitrova; US2015/72982; (2015); (A1) English, View in Reaxys; Patent; SUNSHINE LAKE PHARMA CO., LTD; Zhang, Yingjun; Zhang, Jaincun; Xie, Hongming; Ren, Qingyun; Tan, Yumei; Luo, Huichao; US2015/79028; (2015); (A1) English, View in Reaxys; Balieu, Sebastien; Hallett, Gayle E.; Burns, Matthew; Bootwicha, Teerawut; Studley, John; Aggarwal, Varinder K.; Journal of the American Chemical Society; vol. 137; nb. 13; (2015); p. 4398 - 4403, View in Reaxys; Patent; IDENIX PHARMACEUTICALS, INC.; DOUSSON, Cyril, B.; PAPARIN, Jean-Laurent; WO2015/42375; (2015); (A1) English, View in Reaxys; Komsta, Zofia; Mayes, Benjamin A.; Moussa, Adel; Shelbourne, Montserrat; Stewart, Alistair; Tyrrell, Andrew J.; Wallis, Laura L.; WeymouthWilson, Alexander C.; Yurek-George, Alexander; Organic Letters; vol. 16; nb. 18; (2014); p. 4878 - 4880, View in Reaxys; Patent; The University of Kansas; Tanol, Mehmet; Weir, Scott J.; US2015/111858; (2015); (A1) English, View in Reaxys 34 of 37

Comment (Pharmacological Data)

Bioactivities present

Morgan; Hollingsworth; Bull; Organic and Biomolecular Chemistry; vol. 13; nb. 18; (2015); p. 5265 - 5272, View in Reaxys; Engle, Keary M.; Lu, Gang; Luo, Shao-Xiong; Henling, Lawrence M.; Takase, Michael K.; Liu, Peng; Houk; Grubbs, Robert H.; Journal of the American Chemical Society; vol. 137; nb. 17; (2015); p. 5782 5792, View in Reaxys; Huang, Jun; Fang, Lichao; Gong, Jianxian; Li, Chuangchuang; Yang, Zhen; Tetrahedron; vol. 71; nb. 22; (2015); p. 3720 - 3733, View in Reaxys; Baker, Joseph B.; Kim, Hyoungsu; Hong, Jiyong; Tetrahedron Letters; vol. 56; nb. 23; (2015); p. 3120 - 3122, View in Reaxys; El Bouakher, Abderrahman; Allouchi, Hassan; Abrunhosa-Thomas, Isabelle; Troin, Yves; Guillaumet, Grald; European Journal of Organic Chemistry; vol. 2015; nb. 16; (2015); p. 3450 - 3461, View in Reaxys; Patent; UCB BIOPHARMA SPRL; ALEXANDER, Rikki Peter; BROWN, Julien Alistair; DELIGNY, Michael; HEER, Jag Paul; JACKSON, Victoria Elizabeth; JADOT, Sophie; KROEPLIEN, Boris; MAC COSS, Malcolm; SABNIS, Yogesh Anil; SWINNEN, Dominique Louis Léon; VAN HOUTVIN, Nathalie; ZHU, Zhaoning; WO2015/86527; (2015); (A1) English, View in Reaxys; Patent; SUNOVION PHARMACEUTICALS INC.; NEWCOM, Jason, S.; SPEAR, Kerry, L.; WO2015/88565; (2015); (A1) English, View in Reaxys; Patent; SUNOVION PHARMACEUTICALS INC.; NEWCOM, Jason, S.; SPEAR, Kerry, L.; WO2015/88564; (2015); (A1) English, View in Reaxys; Boultwood, Tom; Affron, Dominic P.; Bull, James A.; Tetrahedron; vol. 71; nb. 30; (2015); p. 4949 - 4957, View in Reaxys; Patent; PFIZER LIMITED; SKERRATT, Sarah Elizabeth; BAGAL, Sharanjeet Kaur; SWAIN, Nigel Alan; OMOTO, Kiyoyuki; ANDREWS, Mark David;

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WO2015/92610; (2015); (A1) English, View in Reaxys; Patent; GENENTECH, INC.; THE UNIVERSITY OF AUCKLAND; LEE, Ho Huat; TERCEL, Moana; FLYGARE, John A.; GUNZNER-TOSTE, Janet; PILLOW, Thomas H.; SAFINA, Brian; STABEN, Leanna; VERMA, Vishal; WEI, BinQing; ZHAO, Guiling; WO2015/95227; (2015); (A2) English, View in Reaxys; Suzuki, Shinya; Okano, Tsubasa; Horiuchi, Rie; Hareyama, Nana; Amikura, Kazutoshi; Yamamoto, Naoyoshi; Yoshizawa, Yoshitaka; Yagi, Mai; Serizawa, Kanako; Hayashi, Ryoji; Bioorganic and Medicinal Chemistry Letters; vol. 25; nb. 16; (2015); p. 3368 - 3372; Art.No: 22739, View in Reaxys; Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; SHAIR, Matthew, D.; RAMHARTER, Juergen; PELISH, Henry, Efrem; LIAU, Brian, Bor-Jen; AHN, Jae Young; WO2015/100420; (2015); (A1) English, View in Reaxys; Patent; Hartman, George D.; US2015/197493; (2015); (A1) English, View in Reaxys; Patent; Genentech, Inc.; Fauber, Benjamin; Gobbi, Alberto; Rene, Olivier; Bodil van Niel, Monique; Gancia, Emanuela; Gaines, Simon; Laddywahetty, Tammy; Vesey, David; Ward, Stuart; Winship, Paul; US2015/197529; (2015); (A1) English, View in Reaxys; Clarkson, Rob; Komsta, Zofia; Shelbourne, Montserrat; Tyrrell, Andrew J.; Wallis, Laura L.; Weymouth-Wilson, Alexander C.; Mayes, Benjamin A.; Moussa, Adel; Stewart, Alistair; Journal of Organic Chemistry; vol. 80; nb. 4; (2015); p. 2198 - 2215, View in Reaxys; Patent; Novira Therapeutics, Inc.; Hartman, George D.; US2015/225355; (2015); (A1) English, View in Reaxys; Brown, Christopher A.; Aggarwal, Varinder K.; Chemistry - A European Journal; vol. 21; nb. 40; (2015); p. 13900 - 13903, View in Reaxys; Patent; RAQUALIA PHARMA INC.; SHISHIDO, Yuji; OHMI, Masashi; ANDO, Kazuo; WO2015/136947; (2015); (A1) English, View in Reaxys; Lin, Hongkun; Tian, Leiming; Krauss, Isaac J.; Journal of the American Chemical Society; vol. 137; nb. 40; (2015); p. 13176 - 13182, View in Reaxys 35 of 37

Comment (Pharmacological Data)

Bioactivities present

Weiss, Daniel T.; Anneser, Markus R.; Haslinger, Stefan; Pöthig, Alexander; Cokoja, Mirza; Basset, Jean-Marie; Kühn, Fritz E.; Organometallics; vol. 34; nb. 20; (2015); p. 5155 - 5166, View in Reaxys; Patent; Sunshine Lake Pharma Co., Ltd.; ZHANG, Jiancun; ZHANG, Yingjun; XIE, Hongming; REN, Qingyun; LUO, Huichao; YU, Tianzhu; TAN, Yumei; EP2730572; (2015); (B1) English, View in Reaxys; Patent; SYNGENTA PARTICIPATIONS AG; GAGNEPAIN, Julien Daniel Henri; MAITY, Pulakesh; RAJAN, Ramya; JEANMART, Stephane André Marie; LAMBERTH, Clemens; WO2015/162271; (2015); (A1) English, View in Reaxys; Patent; PHARMALEADS; ROQUES, Bernard Pierre; FOURNIE-ZALUSKI, Marie-Claude; PORAS, Hervé; US2015/299116; (2015); (A1) English, View in Reaxys; Patent; AstraZeneca AB; Robl, Jeffrey A.; Sulsky, Richard B.; Augeri, David J.; Magnin, David R.; Hamann, Lawrence G.; Betebenner, David A.; EP2272825; (2015); (B1) English, View in Reaxys; Fujiu, Motohiro; Negishi, Kazuyuki; Guang, Jie; Williard, Paul G.; Kuroki, Shigeki; Mikami, Koichi; Dalton Transactions; vol. 44; nb. 45; (2015); p. 19464 - 19468, View in Reaxys; Patent; ACTELION PHARMACEUTICALS LTD; SIEGRIST, Romain; HEIDMANN, Bibia; STAMM, Simon; GATFIELD, John; BEZENCON, Olivier; WO2015/186056; (2015); (A1) English, View in Reaxys; Patent; TAKASAGO INTERNATIONAL CORPORATION; YAMAMOTO, Kenichi; US2015/353461; (2015); (A1) English, View in Reaxys; Haydl, Alexander M.; Breit, Bernhard; Angewandte Chemie - International Edition; vol. 54; nb. 51; (2015); p. 15530 - 15534; Angew. Chem.; vol. 127; nb. 51; (2015); p. 15750 - 15754,5, View in Reaxys; Kim, Junghoon; Park, Sangwoo; Park, Jinyoung; Cho, Seung Hwan; Angewandte Chemie - International Edition; vol. 55; nb. 4; (2016); p. 1498 - 1501, View in Reaxys; Pace, Vittorio; Castoldi, Laura; Mamuye, Ashenafi Damtew; Langer, Thierry; Holzer, Wolfgang; Advanced Synthesis and Catalysis; vol. 358; nb. 2; (2016); p. 172 - 177, View in Reaxys; Patent; DIVERCHIM; OOSTING, Peter; THOMAS, Emmanuel; PAMUK, Rukiye; FOLLEAS, Benoit; BRAYER, Jean-Louis; DE CARNE CARNAVALET, Benoit; MEYER, Christophe; COSSY, Janine; (85 pag.); US2015/329566; (2015); (A1) English, View in Reaxys; Pace, Vittorio; Pelosi, Azzurra; Antermite, Daniele; Rosati, Ornelio; Curini, Massimo; Holzer, Wolfgang; Chemical Communications; vol. 52; nb. 12; (2016); p. 2639 - 2642, View in Reaxys; Struth, Felix R.; Hirschhaüser, Christoph; European Journal of Organic Chemistry; vol. 2016; nb. 5; (2016); p. 958 - 964, View in Reaxys; Tao, Daniel J.; Slutskyy, Yuriy; Overman, Larry E.; Journal of the American Chemical Society; vol. 138; nb. 7; (2016); p. 2186 - 2189, View in Reaxys; Shi, Jingmiao; Lei, Meng; Wu, Wenkui; Feng, Huayun; Wang, Jia; Chen, Shanshan; Zhu, Yongqiang; Hu, Shihe; Liu, Zhaogang; Jiang, Cheng; Bioorganic and Medicinal Chemistry Letters; vol. 26; nb. 8; (2016); p. 1958 - 1962, View in Reaxys; Patent; ACTELION PHARMACEUTICALS LTD; BEZENCON, Olivier; GATFIELD, John; HEIDMANN, Bibia; SIEGRIST, Romain; STAMM, Simon; (86 pag.); WO2016/41892; (2016); (A1) English, View in Reaxys; Nguyen, Minh H.; Imanishi, Masashi; Kurogi, Taichi; Smith, Amos B.; Journal of the American Chemical Society; vol. 138; nb. 11; (2016); p. 3675 - 3678, View in Reaxys; Landry, Matthew L.; Hu, Dennis X.; McKenna, Grace M.; Burns, Noah Z.; Journal of the American Chemical Society; vol. 138; nb. 15; (2016); p. 5150 - 5158, View in Reaxys; Duque-Bentez, Sandra M.; RosVsquez, Luz Amalia; Ocampo-Cardona, Rogelio; Cedeo, David L.; Jones, Marjorie A.; Vlez, Ivn D.; Robledo, Sara M.; Molecules; vol. 21; nb. 4; (2016); Art.No: 381, View in Reaxys 36 of 37

Comment (Pharmacological Data)

Bioactivities present

Smith, Aaron C.; Cabral, Shawn; Kung, Daniel W.; Rose, Colin R.; Southers, James A.; Garca-Irizarry, Carmen N.; Damon, David B.; Bagley, Scott W.; Griffith, David A.; Journal of Organic Chemistry; vol. 81; nb. 9; (2016); p. 3509 - 3519, View in Reaxys; Luo, Fei-Xian; Xu, Xing; Wang, Ding; Cao, Zhi-Chao; Zhang, Yun-Fei; Shi, Zhang-Jie; Organic Letters; vol. 18; nb. 9; (2016); p. 2040 - 2043, View in Reaxys; Patent; BIOGEN MA INC.; CHAO, Jianhua; LUCAS, Brian; (140 pag.); WO2016/65264; (2016); (A1) English, View in Reaxys; Patent; MERCK SHARP and DOHME CORP.; FISCHER, Christian; BOGEN, Stephane, L.; CHILDERS, Matthew, L.; LLINAS, Francesc Xavier Fradera; ELLIS, J. Michael; ESPOSITE, Sara; HONG, Qingmei; HUANG, Chunhui; KIM, Alexander, J.; LAMPE, John, W.; MACHACEK, Michelle, R.; MCMASTERS, Daniel, R.; OTTE, Ryan, D.; PARKER, Dann, L., Jr.; REUTERSHAN, Michael; SCIAMMETTA, Nunzio; SHAO, Pengcheng, P.; SLOMAN, David, L.; UJJAINWALLA, Feroze; WHITE, Catherine; WU, Zhicai; YU, Yang; ZHAO, Kake; GIBEAU, Craig; BIFTU, Tes-

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faye; BIJU, Purakkattle; CHEN, Lei; CLOSE, Joshua; FULLER, Peter, H.; HUANG, Xianhai; PARK, Min, K.; SIMOV, Vladimir; WITTER, David, J.; ZHANG, Hongjun; (297 pag.); WO2016/89797; (2016); (A1) English, View in Reaxys; Patent; FUJIFILM Corporation; KUBO, Yohei; ANDO, Makoto; TANAKA, Hidehiko; OSAKA, Shuhei; MATSUMOTO, Takuya; NAKATA, Hiyoku; TERADA, Daisuke; NITABARU, Tatsuya; (379 pag.); US2016/168139; (2016); (A1) English, View in Reaxys; Patent; Genentech, Inc.; Fauber, Benjamin; Gobbi, Alberto; Rene, Olivier; van Niel, Monique Bodil; Gancia, Emanuela; Gaines, Simon; Ladduwahetty, Tammy; Vesey, David; Ward, Stuart; Winship, Paul; (101 pag.); US2016/168141; (2016); (A1) English, View in Reaxys; Williams, Michael J.; Chen, Qinghao; Codan, Lorenzo; Dermenjian, Renee K.; Dreher, Spencer; Gibson, Andrew W.; He, Xianliang; Jin, Yan; Keen, Stephen P.; Lee, Alfred Y.; Lieberman, David R.; Lin, Wei; Liu, Guiquan; McLaughlin, Mark; Reibarkh, Mikhail; Scott, Jeremy P.; Strickfuss, Sophie; Tan, Lushi; Varsolona, Richard J.; Wen, Feng; Organic Process Research and Development; vol. 20; nb. 7; (2016); p. 1227 - 1238, View in Reaxys; René, Olivier; Fauber, Benjamin P.; Barnard, Adrian; Chapman, Kerry; Deng, Yuzhong; Eidenschenk, Céline; Everett, Christine; Gobbi, Alberto; Johnson, Adam R.; La, Hank; Norman, Maxine; Salmon, Gary; Summerhill, Susan; Wong, Harvey; Bioorganic and Medicinal Chemistry Letters; vol. 26; nb. 18; (2016); p. 4455 - 4461, View in Reaxys 37 of 37

Effect (Pharmacological Data)

mutagenic

Species or Test-System (Pharmacological Data)

Salmonella typhimurium TA1535 cells

Kind of Dosing (Pharmacological Data)

the title comp. was dissolved in water at 25 deg C and subsequently diluted into sterile phosphate buffer, pH 7.4

Method (Pharmacological Data)

the cells were transformed with vectors pKK233-2 or pTrc99A; 100 μl of culture; 0.2 M phosphate buffer, pH 7.4; 5 min; 37 deg C; mixed with top agar and plated on minimal glucose plates; controls were transformed with vectors without enzyme expression

Further Details (Pharmacological Data)

Ames revers. test; pKK233-2 expressed rat glutathione transferase 5-5 (GST 5-5) or human glutathione transferase GST T1 with C-terminal pentahistidine tag (GST T1); pTrc99A expressed bact. dichloromethane dehalogenase from Methylophilus sp. DM11 (DM11)

Results

mutation rate (revertants/mM per plate) in cells expressing DM11/GST 5-5/GST T1 (the control value in parenthesis): 139/177/below detection limit (below detection limit)

Wheeler; Stourman; Thier; Dommermuth; Vuilleumier; Rose; Armstrong; Guengerich; Chemical Research in Toxicology; vol. 14; nb. 8; (2001); p. 1118 - 1127, View in Reaxys Exposure Assessment (5) Exposure Sources

References

presence in drink- treating East Fork ing water concen- Lake water in trate Ohio by coagulation followed by chlorination or ozonation/postchlorination, spiking with bromide and iodide and concentrating by reverse osmosis

Richardson, Susan D.; Thruston Jr., Alfred D.; Krasner, Stuart W.; Weinberg, Howard S.; Miltner, Richard J.; Schenck, Kathleen M.; Narotsky, Michael G.; McKague, A. Bruce; Simmons, Jane Ellen; Journal of Toxicology and Environmental Health - Part A: Current Issues; vol. 71; nb. 17; (2008); p. 1165 - 1186, View in Reaxys

formation in aqueous solution from CsI and dichloromethane in irradiation conditions as a result of nuclear reactor accidents; migration in gas phase; model study

Taghipour, Fariborz; Evans, Greg J.; Environmental Science and Technology; vol. 34; nb. 14; (2000); p. 3012 - 3017, View in Reaxys

incineration of io- Jay, K.; Stieglitz, L.; Chemosphere; vol. 30; nb. 7; (1995); p. 1249 - 1260, dine bearing View in Reaxys waste; presence in clean offgas; waste incineration plant; Germany important sources release from Arcfor halogen raditic (Spitsbergen,

Laturnus; Chemosphere; vol. 31; nb. 6; (1995); p. 3387 - 3395, View in Reaxys

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cals in atmosphere; influence on ozone concentration

Disko Island) and Antarctic (King George Island) marcoalgae (Phaeophyta, Rhodophyta, Chlorophyta) invesigated in laboratory cond. in glass vessel by purge, trap, and GC technique; release rate measured

polar coastal seawater and corresponding atmosphere

macroalgae: Lam- Schall, C.; Laturnus, F.; Heumann, K. G.; Chemosphere; vol. 28; nb. 7; (1994); p. 1315 inaria saccharina, - 1324, View in Reaxys Desmarestia aculeata, Fucus distichus

Concentration in the Environment (1) 1 of 1

Media (Concentration in the Environment)

seawater

Location

Bay of Bengal

Contamination Concentration

0 - 13 ng/l

Method, Remarks (Concentration in the Environment)

water samples collected from depths of 0-500, 0-1000 or 0-1500 m at 7 stations in Bay of Bengal; 13-20 February 1995; in vials with HgCl2; purge and trap system; GC/MS; max conc. found between depths of 30-70 m; mean value; depth profiles in diagrams

Yamamoto, Hideki; Yokouchi, Yoko; Otsuki, Akira; Itoh, Hiroyasu; Chemosphere; vol. 45; nb. 3; (2001); p. 371 377, View in Reaxys Transport and Distribution (1) 1 of 1

Type (Transport and Distribution)

release

Media (Transport and Distribution)

macroalgae-air

Results

release rate ranged from 0 to 0.65 ng g-1 wet alga weight d-1; formation mechanism discussed

Method, Remarks (Transport and Distribution)

Arctic and Antarctic macroalgae (Phaeophyta, Rhodophyta, Chlorophyta) placed in sealed glass vessel with nat. seawater; isol. and identif. by purge and trap technique; GC column with high stationary phase thickness

Laturnus; Chemosphere; vol. 31; nb. 6; (1995); p. 3387 - 3395, View in Reaxys Bioaccumulation, Biomagnification and Biomonitoring (3) 1 of 3

Species (Bioaccumulation, Biomagnification and Biomonitoring)

Laminaria saccharina, brown algae

Media (Bioaccumulation, Biomagnification and Biomonitoring)

seawater

Method, Remarks (Bioaccumulation, Biomagnification and Biomonitoring)

releasing rate: 0.2 ng/g wet weight.d; mean value; algae from shore site of Kongsfjord, German Station Koldewey (78deg93'N, 11deg95'E), Spitsbergen; September 1992; cultivated in incubation vessel on Spitsbergen, polar conditions; electron capture det.

Schall, C.; Laturnus, F.; Heumann, K. G.; Chemosphere; vol. 28; nb. 7; (1994); p. 1315 - 1324, View in Reaxys 2 of 3

Species (Bioaccumulation, Biomagnification and Biomonitoring)

Desmarestia aculeata, brown algae

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Media (Bioaccumulation, Biomagnification and Biomonitoring)

seawater

Method, Remarks (Bioaccumulation, Biomagnification and Biomonitoring)

releasing rate: 0.04 ng/g wet weight.d; mean value; algae from shore site of Kongsfjord, German Station Koldewey (78deg93'N, 11deg95'E), Spitsbergen; September 1992; cultivated in incubation vessel on Spitsbergen, polar conditions; electron capture det.

Schall, C.; Laturnus, F.; Heumann, K. G.; Chemosphere; vol. 28; nb. 7; (1994); p. 1315 - 1324, View in Reaxys 3 of 3

Species (Bioaccumulation, Biomagnification and Biomonitoring)

Fucus distichus, brown algae

Media (Bioaccumulation, Biomagnification and Biomonitoring)

seawater

Method, Remarks (Bioaccumulation, Biomagnification and Biomonitoring)

releasing rate: 0.16 ng/g wet weight.d; mean value; algae from shore site of Kongsfjord, German Station Koldewey (78deg93'N, 11deg95'E), Spitsbergen; September 1992; cultivated in incubation vessel on Spitsbergen, polar conditions; electron capture det.

Schall, C.; Laturnus, F.; Heumann, K. G.; Chemosphere; vol. 28; nb. 7; (1994); p. 1315 - 1324, View in Reaxys

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