1-(4-Bromo-2,5-dimethoxyphenyl)propan-2-amine [DOB]

Page 1

Reaxys

PubChem

eMolecules

Reactions (18)

Yield

Substances (5)

Citations (8)

Conditions

References

1

Synthesize Find similar With hydrogen bromide; bromine in acetic acid

Synthesize Find similar

Rx-ID: 965020 Find similar reactions

Aldous,F.A.B. et al.

Journal of Medicinal Chemistry, 1974 , vol. 17, p. 1100 - 1111 Full Text View citing articles Show Details

2

Synthesize

Synthesize

Rx-ID: 1148538


Find similar

Find similar

Find similar reactions

With hydrogen bromide; bromine in acetic acid

Aldous,F.A.B. et al.

Journal of Medicinal Chemistry, 1974 , vol. 17, p. 1100 - 1111 Full Text View citing articles Show Details

With bromine in acetic acid

Nichols; Barfknecht; Rusterholz; Benington; Morin

Journal of medicinal chemistry, 1973 , vol. 16, # 5 p. 480 - 483 Title/Abstract Full Text View citing articles Show Details

3

Synthesize Find similar

Synthesize Find similar

Rx-ID: 1148540 Find similar reactions

With hydrogen bromide; bromine in acetic acid

Aldous,F.A.B. et al.

Journal of Medicinal Chemistry, 1974 , vol. 17, p. 1100 - 1111 Full Text View citing articles Show Details

With bromine in acetic acid

Nichols; Barfknecht; Rusterholz; Benington; Morin

Journal of medicinal chemistry, 1973 , vol. 16, # 5 p. 480 - 483 Title/Abstract Full Text View citing articles Show Details

4

Synthesize Find similar 53%

5

With aluminium hydride in tetrahydrofuran

6 h; Ambient temperature;

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Rx-ID: 2048959 Find similar reactions

Glennon, Richard A.; McKenney, J. D.; Lyon, Robert A.; Titeler, Milt

Journal of Medicinal Chemistry, 1986 , vol. 29, # 2 p. 194 - 199 Title/Abstract Full Text View citing articles Show Details


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Synthesize Find similar

Rx-ID: 2793711 Find similar reactions

With lithium aluminium tetrahydride

Barfknecht; Nichols

Journal of medicinal chemistry, 1971 , vol. 14, # 4 p. 370 - 372 Title/Abstract Full Text View citing articles Show Details

With lithium aluminium tetrahydride; sulfuric acid in tetrahydrofuran

Ambient temperature;

Glennon, Richard A.; Raghupathi, Reva; Bartyzel, Piotr; Teitler, Milt; Leonhardt, Sigrun

Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 734 - 740 Title/Abstract Full Text View citing articles Show Details

6

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With sodium hydroxide in ethylene glycol

Heating;

Rx-ID: 4306618 Find similar reactions

Coutts; Malicky

Canadian Journal of Chemistry, 1973 , vol. 51, # 9 p. 1402 - 1409 Title/Abstract Full Text View citing articles Show Details

7

Synthesize Find similar entspr. Dimethoxybenzol, Br2;

Rx-ID: 8021953 Find similar reactions

Univ. Iowa

Patent: US4000197 , 1976 ; Chem.Abstr., vol. 86, # 139599 Full Text Show Details


8

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Rx-ID: 8021954 Find similar reactions

entspr. Dimethoxybenzol, Br2;

Univ. Iowa

Patent: US4000197 , 1976 ; Chem.Abstr., vol. 86, # 139599 Full Text Show Details

9

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Synthesize Find similar

Rx-ID: 20987726 Find similar reactions

Multi-step reaction with 2 steps 1: ammonium acetate / 1.) reflux, 8 h, 2.) RT, 60 h 2: LiAlH4, H2SO4 / tetrahydrofuran / Ambient temperature View Scheme

Glennon, Richard A.; Raghupathi, Reva; Bartyzel, Piotr; Teitler, Milt; Leonhardt, Sigrun

Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 734 - 740 Title/Abstract Full Text View citing articles Show Details

Multi-step reaction with 2 steps 1: NH4OAc / acetic acid 2: LiAlH4

View Scheme

Barfknecht; Nichols

Journal of medicinal chemistry, 1971 , vol. 14, # 4 p. 370 - 372 Title/Abstract Full Text View citing articles Show Details

10

Synthesize Find similar Multi-step reaction with 3 steps 2: (i) H2, Pd-C, (ii) PhNCS, (iii) CF3CO2H 3: Br2, HBr / acetic acid View Scheme

Synthesize Find similar

Rx-ID: 22640508 Find similar reactions

Aldous,F.A.B. et al.

Journal of Medicinal Chemistry, 1974 , vol. 17, p. 1100 - 1111 Full Text View citing articles Show Details


11

Synthesize Find similar Multi-step reaction with 3 steps 2: (i) H2, Pd-C, (ii) PhNCS, (iii) CF3CO2H 3: Br2, HBr / acetic acid View Scheme

Synthesize Find similar

Rx-ID: 22640509 Find similar reactions

Aldous,F.A.B. et al.

Journal of Medicinal Chemistry, 1974 , vol. 17, p. 1100 - 1111 Full Text View citing articles Show Details

12

Synthesize Find similar Multi-step reaction with 3 steps 1: Br2, SnCl4

2: NH4OAc / acetic acid 3: LiAlH4

View Scheme

Synthesize Find similar

Rx-ID: 22670797 Find similar reactions

Barfknecht; Nichols

Journal of medicinal chemistry, 1971 , vol. 14, # 4 p. 370 - 372 Title/Abstract Full Text View citing articles Show Details

13

Synthesize Find similar Multi-step reaction with 2 steps 1: (i) H2, Pd-C, (ii) PhNCS, (iii) CF3CO2H 2: Br2, HBr / acetic acid View Scheme

Synthesize Find similar

Rx-ID: 22676241 Find similar reactions

Aldous,F.A.B. et al.

Journal of Medicinal Chemistry, 1974 , vol. 17, p. 1100 - 1111 Full Text View citing articles Show Details


14

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Multi-step reaction with 2 steps 1: (i) H2, Pd-C, (ii) PhNCS, (iii) CF3CO2H 2: Br2, HBr / acetic acid View Scheme

Synthesize Find similar

Rx-ID: 22676243 Find similar reactions

Aldous,F.A.B. et al.

Journal of Medicinal Chemistry, 1974 , vol. 17, p. 1100 - 1111 Full Text View citing articles Show Details

15

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Multi-step reaction with 2 steps 1: H2 / Pd-C / methanol; H2O 2: Br2 / acetic acid View Scheme

Synthesize Find similar

Rx-ID: 22678811 Find similar reactions

Nichols; Barfknecht; Rusterholz; Benington; Morin

Journal of medicinal chemistry, 1973 , vol. 16, # 5 p. 480 - 483 Title/Abstract Full Text View citing articles Show Details

16

Synthesize Find similar

Multi-step reaction with 2 steps 1: H2 / Pd-C / methanol; H2O 2: Br2 / acetic acid View Scheme

Synthesize Find similar

Rx-ID: 22678813 Find similar reactions

Nichols; Barfknecht; Rusterholz; Benington; Morin

Journal of medicinal chemistry, 1973 , vol. 16, # 5 p. 480 - 483 Title/Abstract Full Text View citing articles Show Details


17

Synthesize Find similar Multi-step reaction with 2 steps 1: aq. Br2 / dioxane 2: aq. NaOH / ethane-1,2-diol / Heating View Scheme

Synthesize Find similar

Rx-ID: 22737731 Find similar reactions

Coutts; Malicky

Canadian Journal of Chemistry, 1973 , vol. 51, # 9 p. 1402 - 1409 Title/Abstract Full Text View citing articles Show Details

18

Synthesize Find similar With bromine; acetic acid

3 h;

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Rx-ID: 11154055 Find similar reactions

Xu, Ya-Zhu; Lin, Huei-Ru; Lua, Chang-Ahai; Chen, Chinpiao

Journal of the Chinese Chemical Society, 2007 , vol. 54, # 2 p. 493 - 502 Title/Abstract Full Text View citing articles Show Details


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